Abrégé

A self-emulsifying pharmaceutical composition for delivering taxanes is disclosed. It comprises taxane, oil, surfactant and ethanol, preferably also comprises lactic acid. The surfactant is phospholipid or polyoxyethylenated castor oil. When added into the glucose injection, the self-emulsifying pharmaceutical composition immediately forms a microemulsion with a particle size of 50-300 nm. The microemulsion is stable for more than 12 hours at room temperature.

Classes IPC  ?

• A61K 9/107 - Émulsions
• A61K 31/337 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à quatre chaînons, p. ex. taxol
• A61P 35/00 - Agents anticancéreux

Abrégé

Phenylcyclobutylamide derivatives and their optical isomers, the preparing processes and the uses thereof, which including the compounds of formula (I), their pure stereoisomers and their pharmaceutically acceptable salts. In formula (I), R is H, formacyl, acetyl, haloacetyl, benzoyl, benzyloxy carbonyl(Cbz), t-butoxy carbonyl(Boc), or 9- fluorenyl methoxyl carbonyl(Fmoc).The present novel compounds have pharmaceutical activity and are prepared by condensation reaction of racemic, levo- or dextro- demethyl Sibutramine and racemic or D/L isoleucine under a mild condition. It is demonstrated that the present compounds have effect of losing weight to obese mode rats in different level and the effect is better than Sibutramine by the animal experiments. So the medicaments prepared by the present compounds or the medicaments prepared by the compositions of the present compounds and other pharmaceutical activity compounds may be used for treating obesity.

Classes IPC  ?

• C07C 237/06 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant les atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques du squelette carboné le squelette carboné étant acyclique et saturé ayant les atomes d'azote des groupes carboxamide liés à des atomes d'hydrogène ou à des atomes de carbone acycliques
• A61K 31/16 - Amides, p. ex. acides hydroxamiques
• A61P 3/04 - AnorexigènesMédicaments de l'obésité
• C07C 211/26 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant au moins un cycle aromatique à six chaînons