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Résultats pour
 brevets
1.
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PROCESS FOR PREPARATION OF 7-PHENYLACETAMIDO-3-CHLOROMETHYL-3-CEPHEM-4- CARBOXYLIC ACID P-METHOXYBENZYL ESTER
| Numéro d'application |
CN2008001019 |
| Numéro de publication |
2009/129662 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2008-05-26 |
| Date de publication |
2009-10-29 |
| Propriétaire |
HNG CHEMBIO. PHARMACY CO., LTD (Chine)
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| Inventeur(s) |
- Mo, Zhanghua
- Zhang, Shixi
- Pan, Xiangdong
- Liu, Heping
- Xie, Weili
- Lei, Liangping
- Tao, Xiaoling
- Liu, Chao
- Li, Tao
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Abrégé
A process for the preparation of 7-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester(GCLE), comprises the steps of: reacting penicillin G potassium salt with 4-methoxybenzyl chloride to obtain penicillin G 4-methoxybenzyl ester; oxidizing with peracetic acid to obtain penicillin G sulfoxide p-methoxybenzyl ester; treating with 2-mercaptobenzothiazole, followed by phenylsulfinic acid, to obtain a ring-opening intermediate; further treating with chlorine gas to obtain a chlorinated product; and ring-closing in the presence of ammonia gas to obtain 7-phenylacetamido-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester (GCLE).
Classes IPC ?
- C07D 501/24 - Acides acylamino-7 céphalosporaniques ou acylamino-7 céphalosporaniques substitués dans lesquels les radicaux acyle sont dérivés d'acides carboxyliques avec des radicaux hydrocarbonés, substitués par des hétéro-atomes ou par des hétérocycles, liés en position 3
- C07D 501/02 - Préparation
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2.
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A PROCESS FOR PREPARING 5-HYDROXYMETHYLTHIAZOLE
| Numéro d'application |
CN2008001018 |
| Numéro de publication |
2009/129661 |
| Statut |
Délivré - en vigueur |
| Date de dépôt |
2008-05-26 |
| Date de publication |
2009-10-29 |
| Propriétaire |
HNG CHEMBIO. PHARMACY CO., LTD (Chine)
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| Inventeur(s) |
- Zhang, Shixi
- Mo, Zhanghua
- Wang, Xinhua
- Sun, Hanzhou
- Jiang, Youqing
- Li, Caifa
- Lei, Liangping
- Xie, Weiyue
- Chen, Jiaoshou
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Abrégé
A process for preparing 5-hydroxymethylthiazole, which comprises the following steps: reacting 2-chloro -5-chloromethylthiazole with sodium acetate trihydrate in the presence of ethanol to provide an ester, and after purification, reducing the ester with Zn powder in ethanol, and then hydrolysising with sodium hydroxide to obtain the object product, afterwards, providing the final product through concentration, filtration and distillation.
Classes IPC ?
- C07D 277/24 - Radicaux substitués par des atomes d'oxygène
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