A spray assembly for dispensing a mixture is provided. The spray assembly includes a connector configured for operable engagement with a first and second source of component and a source of pressurized fluid, and a tip operably connected to the connector. The tip includes an opening and defines a mixing chamber between the connector and the opening of the tip, and an insert member configured to be received in the mixing chamber. The insert member includes a plurality of radially extending slots on at least one end of the insert. The plurality of radially extending slots is configured to mix the first and second components prior to the mixture exiting the opening in the tip.
A61B 17/03 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
B05B 1/34 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour influencer la forme de l'écoulement du liquide ou d'autre matériau fluide, p. ex. pour produire une turbulence
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A spray assembly for dispensing a mixture is provided. The spray assembly includes a connector configured for operable engagement with a first and second source of component and a source of pressurized fluid, and a tip operably connected to the connector. The tip includes an opening and defines a mixing chamber between the connector and the opening of the tip, and an insert member configured to be received in the mixing chamber. The insert member includes a plurality of radially extending slots on at least one end of the insert. The plurality of radially extending slots is configured to mix the first and second components prior to the mixture exiting the opening in the tip.
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
B05B 1/34 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour influencer la forme de l'écoulement du liquide ou d'autre matériau fluide, p. ex. pour produire une turbulence
A61B 17/03 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A spray assembly for dispensing a mixture is provided. The spray assembly includes a connector configured for operable engagement with a first and second source of component and a source of pressurized fluid, and a tip operably connected to the connector. The tip includes an opening and defines a mixing chamber between the connector and the opening of the tip, and an insert member configured to be received in the mixing chamber. The insert member includes a plurality of radially extending slots on at least one end of the insert. The plurality of radially extending slots is configured to mix the first and second components prior to the mixture exiting the opening in the tip.
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
B05B 1/34 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour influencer la forme de l'écoulement du liquide ou d'autre matériau fluide, p. ex. pour produire une turbulence
A61M 35/00 - Dispositifs pour appliquer des agents, p. ex. des remèdes, sur le corps humain
B01F 5/06 - Mélangeurs dans lesquels les composants du mélange sont pressés ensemble au travers de fentes, d'orifices, ou de tamis
B05B 15/06 - Montage, dispositifs de maintien ou de soutien des têtes de pulvérisation ou autres organes de projection lorsqu'ils sont en service ou au repos (B05B 15/10 a priorité)
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
B01F 5/00 - Mélangeurs à écoulement; Mélangeurs pour matériaux tombants, p.ex. particules solides
A spray assembly for dispensing a mixture is provided. The spray assembly includes a connector configured for operable engagement with a first and second source of component and a source of pressurized fluid, and a tip operably connected to the connector. The tip includes an opening and defines a mixing chamber between the connector and the opening of the tip, and an insert member configured to be received in the mixing chamber. The insert member includes a plurality of radially extending slots on at least one end of the insert. The plurality of radially extending slots is configured to mix the first and second components prior to the mixture exiting the opening in the tip.
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
B05B 1/34 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour influencer la forme de l'écoulement du liquide ou d'autre matériau fluide, p. ex. pour produire une turbulence
A61M 35/00 - Dispositifs pour appliquer des agents, p. ex. des remèdes, sur le corps humain
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
B01F 5/06 - Mélangeurs dans lesquels les composants du mélange sont pressés ensemble au travers de fentes, d'orifices, ou de tamis
B05B 15/06 - Montage, dispositifs de maintien ou de soutien des têtes de pulvérisation ou autres organes de projection lorsqu'ils sont en service ou au repos (B05B 15/10 a priorité)
B01F 5/00 - Mélangeurs à écoulement; Mélangeurs pour matériaux tombants, p.ex. particules solides
An actuator assembly is provided. The actuator assembly includes housing configured for operable engagement by a user, a trigger assembly operably supported on the housing, a gas cartridge releasably secured to the housing, a valve assembly mounted within the housing for controlling the flow of pressurized gas through the housing and a cylinder actuator operably operably connected to the valve assembly. The cylinder actuator includes a piston selectively extendable therefrom configured for depressing a plunger. The piston includes a head having an inlet surface disposed within an inlet chamber of the cylinder actuator and an outlet surface disposed within the outlet chamber of the cylinder actuator. The exposed surface area of the first surface is equal to the exposed surface of the second surface.
F15B 15/00 - Dispositifs actionnés par fluides pour déplacer un organe d'une position à une autreTransmission associée à ces dispositifs
B05C 17/015 - Outils à main ou appareils utilisant des outils tenus à la main pour appliquer ou étaler des liquides ou d'autres matériaux fluides sur des surfaces, pour enlever partiellement des liquides ou d'autres matériaux fluides des surfaces pour décharger par pression des matériaux à travers un orifice d'évacuation avec un piston actionné pneumatiquement ou analogue
A manifold for use with an applicator assembly is provided. The manifold includes a base having at least a first proximal extension and a distal extension. The at least first proximal extension includes an outer flange and an inner flange and defines a recess therebetween. The manifold further includes at least a first connection member securely affixed to the first proximal extension. The first connection member includes an annular flange configured to be received within the recess of the at least first proximal extension and the annular flange defines a proximal cavity. The manifold further includes at least a first seal member received within the proximal cavity between the first proximal extension and the first connection member. The seal member is configured to permit flow through the manifold in a first direction and obstruct flow through the manifold in a second direction.
F17D 3/00 - Dispositions pour la surveillance ou la commande des opérations de fonctionnement
F16K 15/02 - Soupapes, clapets ou valves de retenue à corps de soupapes rigides guidés
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 7/12 - Pistolets pulvérisateursAppareillages pour l'évacuation agencés pour commander le volume débité, p. ex. à l'aide de passages réglables
B05B 12/08 - Aménagements de commande de la distributionAménagements de réglage de l’aire de pulvérisation sensibles à l'état du liquide ou d'un autre matériau fluide expulsé, du milieu ambiant ou de la cible
B01F 13/00 - Autres mélangeurs; Installations pour effectuer des mélanges comportant des combinaisons de mélangeurs de types différents
7.
Biodegradable osmotic pump implant for drug delivery
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
A61F 13/00 - Bandages ou pansementsGarnitures absorbantes
A61F 2/00 - Filtres implantables dans les vaisseaux sanguinsProthèses, c.-à-d. éléments de substitution ou de remplacement pour des parties du corpsAppareils pour les assujettir au corpsDispositifs maintenant le passage ou évitant l'affaissement de structures corporelles tubulaires, p. ex. stents
A61K 9/52 - Préparations en capsules, p. ex. de gélatine, de chocolat du type à libération prolongée ou discontinue
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
A61K 9/22 - Pilules, pastilles ou comprimés du type à libération prolongée ou discontinue
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
8.
Crosslinked polymers with the crosslinker as therapeutic for sustained release
Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
C07D 207/46 - Composés hétérocycliques contenant des cycles à cinq chaînons, non condensés avec d'autres cycles, ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle avec les hétéro-atomes liés directement à l'atome d'azote du cycle
A61K 47/30 - Composés macromoléculaires organiques ou inorganiques, p. ex. polyphosphates inorganiques
C07C 231/02 - Préparation d'amides d'acides carboxyliques à partir d'acides carboxyliques ou à partir de leurs esters, anhydrides ou halogénures par réaction avec de l'ammoniac ou des amines
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
C08G 65/00 - Composés macromoléculaires obtenus par des réactions créant une liaison éther dans la chaîne principale de la macromolécule
An applicator assembly for mixing at least a first and second component is provided. The applicator assembly includes a manifold configured for operable engagement with at least a first and second source of component, the manifold including at least a first and second component channel therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including at least a first and second component lumen extending the length thereof, the at least first and second component channels in fluid communication with the at least first and second component channels, a tip assembly defining a first chamber, an intermediate chamber and a final chamber.
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
B01F 5/06 - Mélangeurs dans lesquels les composants du mélange sont pressés ensemble au travers de fentes, d'orifices, ou de tamis
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B01F 5/00 - Mélangeurs à écoulement; Mélangeurs pour matériaux tombants, p.ex. particules solides
B01F 13/00 - Autres mélangeurs; Installations pour effectuer des mélanges comportant des combinaisons de mélangeurs de types différents
B05B 1/34 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour influencer la forme de l'écoulement du liquide ou d'autre matériau fluide, p. ex. pour produire une turbulence
B05B 15/06 - Montage, dispositifs de maintien ou de soutien des têtes de pulvérisation ou autres organes de projection lorsqu'ils sont en service ou au repos (B05B 15/10 a priorité)
Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
B32B 27/28 - Produits stratifiés composés essentiellement de résine synthétique comprenant des copolymères de résines synthétiques non complètement couverts par les sous-groupes suivants
A61K 47/30 - Composés macromoléculaires organiques ou inorganiques, p. ex. polyphosphates inorganiques
The present disclosure provides implants suitable for drug delivery. In embodiments, the present disclosure provides layered biodegradable drug delivery implants and systems and methods for making these implants.
B29C 45/14 - Moulage par injection, c.-à-d. en forçant un volume déterminé de matière à mouler par une buse d'injection dans un moule ferméAppareils à cet effet en incorporant des parties ou des couches préformées, p. ex. moulage par injection autour d'inserts ou sur des objets à recouvrir
B29C 45/13 - Appareils de moulage par injection avec au moins deux unités d'injection coopérant avec un seul moule
12.
Biodegradable osmotic pump implant for drug delivery
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
An applicator assembly for mixing at least a first and second component is provided. The applicator assembly includes a manifold configured for operable engagement with at least a first and second source of component, the manifold including at least a first and second component channel therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including at least a first and second component lumen extending the length thereof, the at least first and second component channels in fluid communication with the at least first and second component channels, a tip assembly defining a first chamber, an intermediate chamber and a final chamber.
The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of a lumen of the device, in embodiments the tip of a spray applicator through which the material to be dispensed is expelled from the device, may be controlled to prevent premature gelling.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
in situ polymerizing hydrogel-based medical composition, namely, surgical tissue sealant in International Class 5. Apparatus and instruments for applying a surgical tissue sealant in International Class 10.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
In situ polymerizing hydrogel-based medical composition, namely, surgical tissue sealant and post-surgical adhesion prevention barrier in International Class 5. Apparatus and instruments for applying a surgical tissue sealant and post-surgical adhesion prevention barrier in International Class 10.
A spray tip assembly capable of self-clearing is provided. The spray tip assembly includes a distal end including an outlet. The outlet defines at least a first configuration during a first condition and at least a second configuration during a second condition. The distal end may be configured to at least one of flex and expand such that the outlet changes from the first configuration to the second configuration.
A spray assembly for dispensing a mixture is provided. The spray assembly includes a connector configured for operable engagement with a first and a second source of component and a source of pressurized fluid, and a tip operably connected to the connector. The tip includes an opening and defines a mixing chamber between the connector and the opening of the tip, and an insert member configured to be received in the mixing chamber. The insert member includes a plurality of radially extending slots on at least one end of the insert. The plurality of radially extending slots is configured to mix the first and second components prior to the mixture exiting the opening in the tip.
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 7/10 - Pistolets pulvérisateursAppareillages pour l'évacuation produisant une turbulence à la sortie
B05B 1/34 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage agencés pour influencer la forme de l'écoulement du liquide ou d'autre matériau fluide, p. ex. pour produire une turbulence
An applicator assembly for mixing at least a first and a second component is provided. The applicator assembly includes a manifold configured for operable engagement with first and second source of component, the manifold including first and second component channels therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including first and second component lumens extending the length thereof, the first and second component channels in fluid communication with the first and second component lumens, a tip assembly defining a first chamber, an intermediate chamber and a final chamber, wherein the first chamber is configured to receive a distal end of the elongated shaft, the second chamber is configured to receive an insert, and the final chamber is configured to receive the first and second components prior to the mixture being ejected from an outlet defined in the distal end of the tip assembly.
B05D 7/10 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers à du bois en utilisant des laques ou vernis synthétiques à base de dérivés de la cellulose
Drug delivery devices are provided herein including crosslinked polymeric compositions. The devices may, in embodiments, possess at least two drug release profiles, in embodiments at least three drug release profiles.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) In situ polymerizing hydrogel-based medical devices, namely, sealant preparations for tissue sealing and space filling excluding for use on teeth or in the mouth.
Certain embodiments relate to a sprayer or other medical apparatus for applying a biocompatible coating in situ. Such an apparatus may have a first conduit connected to a first exit opening and a second conduit connected to a second exit opening to deliver a first composition through the first conduit and a second composition through the second conduit to mix the first composition and the second composition outside both the first conduit and the second conduit. The first composition may be, e.g., a precursor to a material formed after the mixing of the first composition and the second composition. The first exit opening and the second exit opening may be approximately adjacent to each other and define an angle that is less than about 140 degrees.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) In situ polymerizing hydrogel-based medical devices, namely, sealant preparations for tissue sealing and space filling excluding for use on teeth or in the mouth.
(2) Medicated patches for sealing and promoting the healing of tissue excluding for use on the teeth or in the mouth.
(3) In situ polymerizing hydrogel-based medical devices, namely, sealant preparations for tissue sealing and space filling excluding for use on teeth or in the mouth; Medicated patches for sealing and promoting the healing of tissue excluding for use on the teeth or in the mouth.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) In situ polymerizing hydrogel-based medical devices, namely, sealant preparations for tissue sealing and space filling excluding for use on teeth or in the mouth; medicated patches for sealing and promoting the healing of tissue (excluding for use on teeth or in the mouth).
medical sealant delivery system, namely, syringe [ and air pump ] used by physicians to administer a dural sealant when performing surgery on cranial openings
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
IN SITU POLYMERIZING HYDROGEL-BASED MEDICAL DEVICES, NAMELY, SEALANT PREPARATIONS FOR TISSUE SEALING AND SPACE FILLING EXCLUDING FOR USE ON TEETH OR IN THE MOUTH; [ PREFORMED PATCHES AND SHEETS SOLD WITH MEDICATION FOR MEDICAL USE EXCLUDING FOR USE ON TEETH OR IN THE MOUTH ]
Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
C08L 101/14 - Compositions contenant des composés macromoléculaires non spécifiés caractérisées par des propriétés physiques, p. ex. anisotropie, viscosité ou conductivité électrique les composés macromoléculaires étant solubles dans l'eau ou gonflables dans l'eau, p. ex. gels aqueux
Drug delivery devices are provided herein including crosslinked polymeric compositions. The devices may, in embodiments, possess at least two drug release profiles, in embodiments at least three drug release profiles.
A61K 47/30 - Composés macromoléculaires organiques ou inorganiques, p. ex. polyphosphates inorganiques
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
An applicator assembly for mixing at least a first and second component is provided. The applicator assembly includes a manifold configured for operable engagement with at least a first and second source of component, the manifold including at least a first and second component channel therethrough, an elongated shaft extending distally from the manifold, the elongated shaft including at least a first and second component lumen extending the length thereof, the at least first and second component channels in fluid communication with the at least first and second component channels, a tip assembly defining a first chamber, an intermediate chamber and a final chamber, wherein the first chamber is configured to receive a distal end of the elongated shaft, the second chamber is configured to receive an insert, and the final chamber is configured to receive the at least partially mixed at least first and second components prior to the mixture being ejected from an outlet defined in the distal end of the tip assembly.
B05B 7/26 - Appareillages dans lesquels des liquides ou d'autres matériaux fluides en provenance de différentes sources sont mélangés avant de pénétrer dans le dispositif d'évacuation
A syringe includes a first fluid conduit and a second fluid conduit. The first fluid conduit includes two chambers for accommodating two substances of a plurality of substances. The second fluid conduit is disposed adjacent the first fluid conduit and has a chamber for accommodating one substance of the plurality of substances. The syringe may include a third fluid conduit. Each substance is intermixable to form a discharge material upon advancement of a plunger operably associated with each fluid conduit. The discharge material is defined by the intermixed composition of predetermined volumes of the substances the fluid conduits. The discharge material may be a hydrogel. A connecting tip may be operably associated with each fluid conduit. A syringe may include an end cap disposed on the end of each of the fluid conduits. The end cap may have a venting feature for enabling gas venting while preventing discharge until desired.
A61B 17/03 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations
A61M 35/00 - Dispositifs pour appliquer des agents, p. ex. des remèdes, sur le corps humain
B05C 17/01 - Outils à main ou appareils utilisant des outils tenus à la main pour appliquer ou étaler des liquides ou d'autres matériaux fluides sur des surfaces, pour enlever partiellement des liquides ou d'autres matériaux fluides des surfaces pour décharger par pression des matériaux à travers un orifice d'évacuation avec un piston actionné mécaniquement, électriquement ou analogue
A spray assembly for dispensing a mixture is provided. The spray assembly includes a connector configured for operable engagement with a first and a second source of component and a source of pressurized fluid, and a tip operably connected to the connector. The tip includes an opening and defines a mixing chamber between the connector and the opening of the tip, and an insert member configured to be received in the mixing chamber. The insert member includes a plurality of radially extending slots on at least one end of the insert. The plurality of radially extending slots is configured to mix the first and second components prior to the mixture exiting the opening in the tip.
A61B 17/03 - Instruments, dispositifs ou procédés chirurgicaux pour refermer les plaies ou les maintenir ferméesAccessoires utilisés en liaison avec ces opérations
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B67D 7/74 - Dispositifs pour mélanger plusieurs liquides à transférer
35.
PREVENTION OF PREMATURE GELLING OF DELIVERY DEVICES FOR PH DEPENDENT FORMING MATERIALS
The present disclosure provides treatment of an apparatus, in embodiments a delivery device, which prevents premature gelling of any materials or precursor(s) of a pH dependent forming material, in embodiments a hydrogel, dispensed by the delivery device. The pH microenvironment near the surface of a lumen of the device, in embodiments the tip of a spray applicator through which the material to be dispensed is expelled from the device, may be controlled to prevent premature gelling.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A spray tip assembly capable of self-clearing is provided. The spray tip assembly includes a distal end including an outlet. The outlet defines at least a first configuration during a first condition and at least a second configuration during a second condition. The distal end may be configured to at least one of flex and expand such that the outlet changes from the first configuration to the second configuration.
B05B 7/04 - Pistolets pulvérisateursAppareillages pour l'évacuation avec des dispositifs permettant le mélange de liquides ou d'autres matériaux fluides avant l'évacuation
B05B 15/50 - Aménagements pour le nettoyageAménagements pour empêcher les dépôts, le séchage ou un blocageAménagements pour détecter une évacuation incorrecte en raison de la présence d’un corps étranger
37.
MODULATING DRUG RELEASE RATE BY CONTROLLING THE KINETICS OF THE PH TRANSITION IN HYDROGELS
Methods and compositions relate to modulating the release profile of drug molecules from a hydrogel by controlling the kinetics of the pH transition of the hydrogel. The hydrogel is formed by in situ polymerization and includes a drug molecule having a pKa between the pH of the formed hydrogel and the physiologic environment in which the hydrogel is placed.
Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.
An actuator assembly is provided. The actuator assembly includes housing configured for operable engagement by a user, a trigger assembly operably supported on the housing, a gas cartridge releasably secured to the housing, a valve assembly mounted within the housing for controlling the flow of pressurized gas through the housing and a cylinder actuator operably operably connected to the valve assembly. The cylinder actuator includes a piston selectively extendable therefrom configured for depressing a plunger. The piston includes a head having an inlet surface disposed within an inlet chamber of the cylinder actuator and an outlet surface disposed within the outlet chamber of the cylinder actuator. The exposed surface area of the first surface is equal to the exposed surface of the second surface.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
B05C 17/015 - Outils à main ou appareils utilisant des outils tenus à la main pour appliquer ou étaler des liquides ou d'autres matériaux fluides sur des surfaces, pour enlever partiellement des liquides ou d'autres matériaux fluides des surfaces pour décharger par pression des matériaux à travers un orifice d'évacuation avec un piston actionné pneumatiquement ou analogue
