The present invention relates to a tissue cell culture device which includes a tissue cell culture body. The porous material used as the tissue cell culture body is a porous metallic material which is formed by pore cavities classified by a pore size of the material and cavity walls surrounding to form the classified pore cavities. The cavity wall surrounding to form an upper level of large pore cavity is provided with a lower level of small pore cavity. The pore cavities in the same level are in communication with each other. The pore cavities in different levels are also in communication with each other. This device is particularly beneficial for cell cultivation and allows tissue cells to grow freely and normally in a three-dimensional space.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
The present invention relates to a porous material, wherein the pores of the porous material are uniformly distributed. The uniform distribution of the pores means that the pores are evenly distributed at any unit-level volume of the porous material. The elastic modulus of the porous material is reduced by 10-99% compared to that of the raw material used to make the porous material. This kind of porous material ensures the uniformity of its various properties. It is a porous material with excellent performance and quality. Its uniformity also ensures that its elastic modulus can be effectively reduced to meet multiple purposes.
B32B 5/18 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par le fait qu'une des couches contient un matériau sous forme de mousse ou essentiellement poreux
C22C 1/08 - Alliages poreux avec pores ouverts ou fermés
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
B01D 46/24 - Séparateurs de particules utilisant des corps filtrants creux et rigides, p. ex. appareils de précipitation de poussières
B33Y 80/00 - Produits obtenus par fabrication additive
B01D 39/16 - Autres substances filtrantes autoportantes en substance organique, p. ex. fibres synthétiques
B01D 39/20 - Autres substances filtrantes autoportantes en substance inorganique, p. ex. papier d'amiante ou substance filtrante métallique faite de fils métalliques non-tissés
B22F 3/11 - Fabrication de pièces ou d'objets poreux
B29C 67/20 - Techniques de façonnage non couvertes par les groupes , ou pour la fabrication d'objets poreux ou cellulaires, p. ex. des mousses plastiques, des mousses alvéolaires
B29K 67/00 - Utilisation de polyesters comme matière de moulage
B29K 105/04 - Présentation, forme ou état de la matière moulée cellulaire ou poreuse
C25D 1/08 - Articles perforés ou foraminés, p. ex. tamis
A porous material and preparation method thereof is provided. The material includes a material body. The body consists of pore cavities classified according to pore size of material and cavity walls surrounding to form the pore cavities. The lower-level pore cavities are arranged on the cavity walls of the upper-level pore cavities framed by surrounding a three-dimensional space. All the pore cavities are interconnected. The preparation method is: mixing raw powders with pore-forming agent for the smallest-level pore cavities of porous material to formulate slurry; uniformly filling the slurry into polymer material support to form green body and get dried and smashed to obtain mixed grains; uniformly mixing the mixed grains with pore-forming agent for upper-level pore cavities greater than the smallest-level pore cavities of porous material to make compact green body; performing vacuum sintering; performing the conventional follow-up treatment according to the raw materials process of porous material.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
B01D 39/20 - Autres substances filtrantes autoportantes en substance inorganique, p. ex. papier d'amiante ou substance filtrante métallique faite de fils métalliques non-tissés
C22C 1/04 - Fabrication des alliages non ferreux par métallurgie des poudres
C04B 35/565 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de carbures à base de carbure de silicium
4.
CRYSTALLINE FORM OF (R)-4-HYDROXY-2-OXO-1-PYRROLIDINEACETAMIDE, PREPARATION METHOD THEREFOR AND USE THEREOF
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A crystalline form of (R)-4-hydroxy-2-oxo-1-pyrrolidineacetamide is disclosed. The crystalline form has a diffraction peak when a diffraction angle, 2θ, is 16.66±0.2°, 17.54±0.2°, 21±0.2°, 22.16±0.2°, or 30.96±0.2°. The crystalline form can be dissolved quickly in water with a solubility greater than or equal to 90 mg/mL, features high bioavailability, has high stability at high temperature, is suitable for preparing multiple pharmaceutical compositions, and can prepare multiple formulations, such as tablets, capsules, dripping pills, sustained-release and controlled-release formulations, and lyophilized powder for injection. The method for preparing the crystalline form is carried out under a mild condition, is easy to operate, introduces a few impurities, and features good reproducibility, an easy-to-control production process and high safety, and is suitable for industrial production.
C07D 207/273 - Pyrrolidones-2 avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED (Chine)
Inventeur(s)
Ye, Lei
Abrégé
The present invention provides a crystalline form of dextral oxiracetam. The crystalline form has a diffraction peak when a diffraction angle, 2θ, is 17.12±0.2°, 18.88±0.2°,19.24±0.2°, 21.18±0.2°, or 24.88±0.2°. The crystalline form having oxiracetam can promote synthesis of phosphorylcholine and phosphoethanolamine, boosts cerebral metabolism, has a stimulating function on a specific central nervous pathway by means of a blood-brain barrier, improves the intelligence and memory, has an obvious effect on a memory dysfunction, and has special biological activity in the field of sedation and the antiepileptic field. The method for preparing the crystalline form is simple and is suitable for industrial production.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
The present invention provides a crystalline form of dextral oxiracetam. The crystalline form has a diffraction peak when a diffraction angle, 2θ, is 17.76±0.2°, 20.16±0.2°, 21.20±0.2°, 24.17±0.2°, or 25.88±0.2°. The crystalline form of dextral oxiracetam can promote synthesis of phosphorylcholine and phosphoethanolamine, boosts cerebral metabolism, has a stimulating function on a specific central nervous pathway by means of a blood-brain barrier, and has special biological activity in the field of sedation and the antiepileptic field. The crystalline form of dextral oxiracetam of the present invention is a water-containing crystalline form, contains 0.5 water molecules, loses crystallization water at 73.5±2ºC, and is melted and decomposed at 138.0±2ºC. The crystalline form of dextral oxiracetam of the present invention can stably exist at room temperature and relative humidity of 0-95％, does not transform, is used for storage and formulation processing, and has low requirements for processing or storage humidity.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
The present invention provides a porous non-metallic material, comprising a material body; the body has pore cavities, and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the pore cavities being uniformly distributed means that the pore cavities are uniformly distributed over any unit volume on the porous material. The present invention provides a concrete and specific means of measuring the uniform distribution of pore cavities; the dimension of the small-unit volume is used to measure the porous material and the pore distribution uniformity of its multi-level structure; thus the porous structure is highly uniform, ensuring uniformity and consistency in the various aspects of performance of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene ultrafine fiber tubular membrane comprises a polytetrafluoroethylene body, wherein the polytetrafluoroethylene is fibrous with the fiber diameter of 30nm-200nm; the body consists of pore cavities having the diameter of 10nm-1000mn and cavity walls dimensionally surrounding the pore cavities in a form of three-dimensional space; the pore cavities are uniformly distributed and three-dimensionally connected, and uniform distribution of the pore cavities means that the pore cavitiesare uniformly distributed in a porous material in any unit volume; the porosity is greater than or equal to 70%.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene hollow fiber membrane, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of 200-2000 nm; the body has pore cavities of a pore diameter of 10-2000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the porosity is ≥65%.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene (PTFE) hollow fiber membrane, comprising a PTFE material body, wherein the PTFE is in the form of fibers ᡶ 200 nm and ≤ 2000 nm in diameter, the body is provided with pore spaces between 10 nm and 2000 nm in diameter, and pore walls are formed around the pore spaces in a three-dimensional space, where the pore spaces are evenly distributed and interconnected in all three dimensions. The pore spaces being evenly distributed is defined herein as each pore space being evenly distributed over the porous material in an arbitrary unit volume; porosity is 80% or greater, tensile strength is higher than 25 N/mm2, and water pressure resistance is higher than 4 kg/cm2. A specific and explicit measurement method for the uniformity of porous distribution of a PTFE hollow fiber membrane is proposed herein. It has been made clear that the porous distribution uniformity of a porous material and the multi-level structure thereof are measured at the scale of a small unit volume, such that the porous structure is highly uniform, thus ensuring the uniformity and consistency in every property of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene hollow fiber membrane comprises a polytetrafluoroethylene material body, wherein the polytetrafluoroethylene is in fibrous shape with the fiber diameter of greater than 200 nm and less than or equal to 2000 nm; the body has cavities with diameters of 10 to 2000 nm and cavity walls formed in a three-dimensional manner surrounding the cavities; and the cavities are uniformly distributed, with each of the cavities being penetrated through in a three-dimensional manner, wherein the cavities being uniformly distributed means that each of the cavities is uniformly distributed at any unit level volume of porous material; wherein porosity is greater than or equal to 75%, transmittance greater than or equal to 50%, tensile strength greater than or equal to 28N / mm 2, and water pressure resistance greater than or equal to 4kg / cm 2.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene fiber tubular membrane, comprising a body of a polytetrafluoroethylene material, the polytetrafluoroethylene material being fibrous with a fiber diameter of greater than 200nm and less than or equal to 2000nm. The body has pore cavities with a pore diameter of 10nm-2000nm and cavity walls formed around the pore cavities in three-dimensional space. The pore cavities are distributed uniformly, each of the pore cavities being three-dimensionally through. The pore cavities are distributed uniformly means that the pore cavities are distributed uniformly in the porous material in a volume of any unit level. The porosity is 65% or more, and the transmittance is 45% or more.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene fiber membrane, comprising a body of a polytetrafluoroethylene material, the polytetrafluoroethylene material being fibrous with a fiber diameter of 30-200nm. The body has pore cavities with a pore diameter of 10nm-1000nm and cavity walls formed around the pore cavities in three-dimensional space, the pore cavities thereof being distributed uniformly, each of the pore cavities being three-dimensionally through. The pore cavities being distributed uniformly means that the pore cavities are distributed uniformly in the porous material in a volume of any unit level. The porosity is 70% or more, the transmittance is 50% or more, the tensile strength is 20N/mm2 or more, and the water pressure resistance is 4kg/cm2 or more. This invention proposes a specific and definite measurement method for the distribution uniformity of the pore cavities in the polytetrafluoroethylene fiber membrane, defining that the uniformity of the pore distribution in the porous material and the multilevel structure thereof is measured in a scale of a volume at low unit level. Such a porous structure is highly uniform, ensuring the uniformity and consistency of the performances of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene (PTFE) fiber membrane, comprising a PTFE material body, wherein the PTFE is in the form of fibers ᡶ 200 nm and ≤ 2000 nm in diameter, the body is provided with pore spaces between 10 nm and 2000 nm in diameter, and pore walls are formed around the pore spaces in a three-dimensional space, where the pore spaces are evenly distributed and interconnected in all three dimensions. The pore spaces being evenly distributed is defined herein as each pore space being evenly distributed over the porous material in an arbitrary unit volume. Porosity is 80% or greater, tensile strength is higher than 25 N/mm2, and water pressure resistance is higher than 4 kg/cm2. The porous distribution uniformity of a porous material and the multi-level structure thereof are measured at the scale of a small unit volume, thus ensuring the uniformity and consistency in every property of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene fiber membrane, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of greater than 200 nm and less than or equal to 2000 nm; the body has pore cavities of a pore diameter of 10-2000 nm, and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the pore cavities being uniformly distributed means that the pore cavities are uniformly distributed over any unit volume on the porous material; the porosity is 65% or higher, and the light transmittance is 45% or higher. The porous structure of the polytetrafluoroethylene fiber membrane is highly uniform, ensuring uniformity and consistency in the various aspects of performance of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene (PTFE) fiber membrane, comprising a PTFE material body, wherein the PTFE is in the form of fibers ᡶ 200 nm and ≤ 2000 nm in diameter, the body is provided with pore spaces between 10 nm and 2000 nm in diameter, and pore walls are formed around the pore spaces in a three-dimensional space, where the pore spaces are evenly distributed and interconnected in all three dimensions. The pore spaces being evenly distributed is defined herein as each pore space being evenly distributed over the porous material in an arbitrary unit volume. Porosity is 65% or greater. The porous structure of the PTFE fiber membrane is highly uniform, thus ensuring uniformity and consistency in every property of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene superfine hollow fiber membrane, comprising a body of a polytetrafluoroethylene material, the polytetrafluoroethylene material being fibrous with a fiber diameter of 30-200nm, the body having pore cavities with a pore diameter of 10nm-1000nm and cavity walls formed around the pore cavities in three-dimensional space, the pore cavities being distributed uniformly with the porosity of equal to or greater than 70%.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene fiber membrane used for membrane distillation, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of 30-200 nm; the body has pore cavities of a pore diameter of 10-1000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the pore cavities being uniformly distributed means that the pore cavities are uniformly distributed over any unit volume on the porous material, and the porosity is ≥70%.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene superfine hollow fiber membrane, comprising a body of polytetrafluoroethylene material, the polytetrafluoroethylene material being fibrous with a fiber diameter of 30-200nm. The body has pore cavities with a pore diameter of 10nm-1000nm and cavity walls formed around the pore cavities in three-dimensional space. The pore cavities are distributed uniformly, each of the pore cavities being three-dimensionally through. The pore cavities are distributed uniformly means that the pore cavities are distributed uniformly in the porous material in a volume of any unit level. The porosity is greater than or equal to 75%, the tensile strength is 15N/mm2 or more, and the water pressure resistance is 3kg/cm2 or more.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene hollow fiber membrane comprises a polytetrafluoroethylene material body, wherein the polytetrafluoroethylene is in fibrous shape with diameters of 30 to 200 nm. The body has cavities with hole diameters of 10 to 1000 nm and cavity walls formed around the cavities in a three-dimensional space, and the cavities are homogeneously distributed, with individual cavities being communicated in a three-dimensional manner. The cavities being homogeneously distributed means that the individual cavities are homogeneously distributed over any unit-level volume of porous material, with porosity of above 65% and transmittance of above 45%. A specific and definite measuring method of the cavity distribution homogeneity in the polytetrafluoroethylene hollow fiber membrane is put forward, and it is clear that the cavity distribution homogeneity of the porous material and its multi-stage structure is measured at a measure of small unit-level volume, thereby such porous structure is highly homogeneous, ensuring homogeneous uniformity of the individual properties of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene hollow fiber membrane, comprising a body of a polytetrafluoroethylene material, the polytetrafluoroethylene material being fibrous with a fiber diameter of 30-200nm. The body has pore cavities with a pore diameter of 10nm-1000nm and cavity walls formed around the pore cavities in three-dimensional space, the pore cavities thereof being distributed uniformly, each of the pore cavities being three-dimensionally through. The pore cavities being distributed uniformly means that the pore cavities are distributed uniformly in the porous material in a volume of any unit level. The porosity is 70% or more, the transmittance is 50% or more, the tensile strength is 20N/mm2 or more, and the water pressure resistance is 4kg/cm2or more. This invention proposes a specific and definite measurement method for the uniform distribution of the pore cavities in the polytetrafluoroethylene hollow fiber membrane, defining that the uniformity of the pore distribution in the porous material and the multilevel structure thereof is measured in a scale of a volume at small unit level. Such a porous structure is highly uniform, thereby ensuring the uniformity and consistency of the performances of the porous material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene hollow fiber membrane, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of greater than 200 nm and less than or equal to 2000 nm; the body has pore cavities of a pore diameter of 10-2000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the pore cavities being uniformly distributed means that the pore cavities are uniformly distributed over any unit volume on the porous material; the porosity is 65% or higher, and the light transmittance is 45% or higher.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene fiber tubular membrane comprising a polytetrafluoroethylene material body, wherein the polytetrafluoroethylene is in fibrous shape with diameter of 30 to 200 nm; the body has cavities with aperture of 10 to 1000 nm and cavity walls formed in a three-dimensional space around the cavities; and the cavities are homogeneously distributed, with each cavities being through in a three-dimensional manner, wherein the cavities being homogeneously distributed means that each of the cavities is homogeneously distributed over any unit-level volume of porous material with porosity≥75%, tensile strength above 15N/mm2, and water pressure resistance above 3kg/cm2.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene fiber tubular membrane, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of 30-200 nm; the body has pore cavities of a pore diameter of 10-1000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the pore cavities being uniformly distributed means that the pore cavities are uniformly distributed over any unit volume on the porous material; the porosity is 65% or higher, and the light transmittance is 45% or higher.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene fiber tubular membrane, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of 30-200 nm; the body has pore cavities of a pore diameter of 10-1000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the pore cavities being uniformly distributed means that the pore cavities are uniformly distributed over any unit volume on the porous material, the porosity is 65% or higher, and the light transmittance is 45% or higher.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene fiber tubular membrane, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber diameter is larger than 200 nm and smaller than or equal to 2000 nm; the body has pore cavities of a pore diameter of 10-2000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the pore cavities being uniformly distributed means that the pore cavities are uniformly distributed over any unit volume on the porous material, and the porosity is greater than or equal to 65%.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene fiber tube film, comprising a polytetrafluoroethylene material body, the polytetrafluoroethylene being fibrous, 200 nm ឬ fibre diameter ≤ 2000 nm, the body being provided with pore cavities having a pore diameter of 10 nm to 2000 nm and a cavity wall formed by surrounding the pore cavity in three-dimensional space, the cavities being distributed uniformly, all the cavities being three-dimensional through-holes, and the cavities being uniformly distributed meaning that the cavities are uniformly distributed on the porous material at any unit scale volume; porosity ≥ 80%, tensile strength is more than 25 N/mm2, and water-resistant pressure is more than 4 kg/cm2.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene fiber tubular membrane comprises: a polytetrafluoroethylene material body, wherein the polytetrafluoroethylene is in fibrous shape with the fiber diameter of greater than 200 nm and less than or equal to 2000 nm; the body has cavities with diameters of 10 to 2000 nm and cavity walls formed in a three-dimensional manner surrounding the cavities; and the cavities are uniformly distributed, with each of the cavities being penetrated through in a three-dimensional manner, wherein the cavities being uniformly distributed means that each of the cavities is uniformly distributed at any unit level volume of porous material; wherein porosity is greater than or equal to 75%, transmittance greater than or equal to 50%, tensile strength greater than or equal to 28N / mm 2, and water pressure resistance greater than or equal to 4kg / cm 2.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Polytetrafluoroethylene ultra-fine fiber tubular membrane comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of 30-200 nm; the body has pore cavities of a pore diameter of 10-1000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the porosity is ≥75%, the tensile strength is 15 N/mm2 or higher, and the water resistance pressure is 3 kg/cm2 or higher.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided is a polytetrafluoroethylene fiber membrane, comprising a polytetrafluoroethylene material body; the polytetrafluoroethylene has a fiber shape and the fiber has a diameter of 30-200 nm; the body has pore cavities of a pore diameter of 10-1000 nm and cavity walls formed by three-dimensional spaces surrounding the pore cavities; the pore cavities are uniformly distributed and each pore cavity is three-dimensionally open; the porosity is 65% or higher, and the light transmittance is 45% or higher.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A polytetrafluoroethylene (PTFE) fiber membrane, comprising a PTFE body, wherein the PTFE is in the form of fibers ᡶ 200 nm and ≤ 2000 nm in diameter, the body is provided with pore spaces between 10 nm and 2000 nm in diameter, and porous walls are formed around the pore spaces in a three-dimensional space, where the pore spaces are evenly distributed and interconnected in all three dimensions. The pore spaces being evenly distributed is defined herein as each pore space being evenly distributed over the porous material in an arbitrary unit volume; porosity is 75% or greater, light transmittance is higher than 50%, tensile strength is higher than 28 N/mm 2, and water pressure resistance is higher than 4 kg/cm 2. A specific and explicit measurement method for the uniformity of porous distribution of a PTFE fiber membrane is also proposed herein. It has been made clear that the porous distribution uniformity of a porous material and the multi-level structure thereof are measured at the scale of a small unit volume, such that the porous structure is highly uniform, thus ensuring the uniformity and consistency in every property of the porous material.
Provided is a porous material having a hierarchical pore structure, wherein the size and shape of a part running between first-size pore cavities is consistent with the size and shape of a part running through said pore cavities and the preceding-size pore cavities, and the average value of the equivalent diameters of the through-parts is larger than 45% of the diameter of the smaller pore cavity of two adjacent pore cavities of the through-part. The method for preparing the porous material comprises: mixing a starting material powder with a pore forming agent used for preparing the smallest pores, formulating a slurry; uniformly filling a polymeric material frame with the slurry, and drying and crushing to form a mixed particulate; then uniformly mixing with the pore forming agent used for preparing the pores of a size preceding the smallest pores, forming a densified blank and sintering same; the structure of the pore forming agent of at least one of the sizes of pores is: any one particle has at least three connecting rods on it, and at least two of the connecting rods are each connected to other particles; the diameter of the connecting rod being larger than 45% of the particle diameter of the pore forming agent, and the length being more than 10% of the particle diameter of the pore forming agent. The through-parts of the material are uniform and may be used as a biomaterial or a separation material, and the preparation method is effective and easy to implement.
Provided is a porous material for a medical implant material, the material substance of the porous material is a hierarchical porous material having a hierarchical pore cavities graded according to pore size of the material; the hierarchical porous material has a permeability greater than 0.5×10-9m2. It can fully guarantee the blood flow to achieve adequate nutrition and growth factor transmission, cell migration, removal of cell debris, stimulation of tissue growth, thereby fully meeting the needs of human tissue regeneration with a variety of functions.
Disclosed is a new use of a porous material. The porous material is composed of a bore cavity and a cavity wall enclosed the bore cavity, wherein the bore cavity is three-dimensional; the capillary force of the porous material is over 5 Pa; and the contact angle between the cavity wall surface of the porous material and the liquid phase substance circulated inside is less than 90°. The porous material can be applied as a micro-circulation power source. In a circulation system, the porous material can be applied as the power source for the micro-circulation providing interchanging of substances. In a separation system, the porous material can be applied as the power source for the micro-circulation providing separation and movement of substances. In a medical implant system, the porous material can be applied as the power source for the micro-circulation providing growth of tissue cells.
A porous metal material. The material is a multi-grade porous metal material. Grading is performed according to material pore diameters, and there are at least two grades. The pore diameter of a minimum-grade porous metal material is less than 1 micrometer, the elastic modulus of the minimum-grade porous metal material is less than 80 GPa, and the porosity is not less than 48%. A preparation method for the porous metal material comprises: mixing raw material powder for preparing the porous metal material and a pore-forming agent for preparing a minimum-grade pore cavity to prepare slurry; uniformly filling the slurry into a high polymer material support, to form a body, and drying and crushing the body to obtain mixed particles; uniformly mixing the mixed particles with a pore-forming agent for preparing a pore cavity that is bigger than the minimum-grade pore cavity, to prepare a compact body; and performing vacuum sintering, and performing regular subsequent treatment according to the raw material process. The material has multi-grade elastic modulus to meet different use requirements, has desirable connectivity, and is particularly suitable to serve as a tissue regeneration material. The preparation method is simple and is easy to implement.
The present invention provides a culture device for tissues, and the culture device comprises a cell culture medium. The cell culture medium has porous metal materials as its materials, and is formed by pore walls and pore chambers classified as different levels by the pore diameter. A lower level small pore chamber is provided on the chamber wall of an upper level large pore chamber. The pore chambers within the same level are in communication with each other, and the pore chambers between different levels are in communication with each other.
The present invention provides a culture device for tissues, and the culture device comprises a cell culture medium. The cell culture medium has a porous member formed by pore walls and pore chambers classified as different levels by the pore diameter, and a lower level small pore chamber is provided on the chamber wall of an upper level large pore chamber. The pore chambers within the same level are in communication with each other, and the pore chambers between different levels are in communication with each other.
A hierarchical porous material comprises a base material comprising porous cavities classified by different material pore diameter sizes and formed by surrounding porous walls. The porous cavities are uniformly distributed. A lower level porous cavity is provided on a cavity wall surrounding in a three-dimensional (3D) space and forming an upper level porous cavity. Each level of porous cavities are mutually communicated with a same level and another level of porous cavities. The uniform distribution of the porous cavities indicates that each level of the porous cavities are uniformly distributed in any unit volume of the hierarchical porous material.
A culture device (1) for tissue cell suspension comprises a tissue cell culture medium (2), and the tissue cell culture medium (2) is a porous member. The porous member is formed by pore chambers (12, 14) classified as different levels according to the pore size of a material and chamber walls (13, 15) surrounding to form the pore chambers, and a lower level small pore chamber (14) is provided surrounding the chamber wall (13) that forms an upper level large pore chamber (12). The pore chambers within each level are in communication with each other, and the pore chambers between respective levels are also in communication with each other. The culture device (1) also comprises a swirler disposed therein. The culture device (1) facilitates suspension of cells to allow normal and unrestricted growth in a three-dimensional space, and obstructs forming of an over-dense cell region or nutrient-rich region, thus enabling a uniform cell distribution and promoting normal cell growth.
C12M 3/02 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus comportant des moyens fournissant des suspensions
A porous material and a preparation method, the material comprising a material body, the body being formed of hole cavities (1) graded by material hole diameter size and cavity walls (2) formed around the hole cavities (1), lower grade hole cavities (3) being arranged on the cavity walls (2) formed around higher grade hole cavities (1) in a three-dimensional space, the hole cavities (1) of the various grades being respectively connected to each other, the hole cavities (1) of the various grades also being mutually inter-connected. The preparation method comprises: mixing a raw material powder and a pore-forming agent used for preparing the smallest grade hole cavities (3) of the porous material to prepare a slurry, uniformly filling the slurry into a polymer material support, forming a blank, drying and crushing to obtain mixed granules, uniformly mixing the mixed granules with a pore-forming agent used for preparing the higher grade hole cavities (1) which are larger than the smallest grade hole cavities (3) of the porous material, preparing a dense blank, vacuum sintering, and performing conventional follow-up treatment according to the raw material process of the porous material.
A porous material comprises pores uniformly distributed in a unit volume of the porous material. The porous has a modulus of elasticity less by 10 to 99% than that of a raw material used to manufacture the porous material. The porous material ensures uniformity and consistency of all kinds of performance, has favorable performance and favorable quality, and the uniformity of the porous material effectively reduces the modulus of elasticity.
A61L 27/18 - Matériaux macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
42.
USE OF DEXTROROTATORY OXIRACETAM IN PHARMACEUTICAL FIELD
Provided is a use of dextrorotatory oxiracetam in the preparation of a drug for preventing or treating epilepsy. An experimental result shows that the dextrorotatory oxiracetam has an obvious effect in the treatment of generalized epilepsy seizure, partial epilepsy seizure and status epilepticus.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
(S)-4-hydroxyl-2-keto-1-piracetam crystal form III (called (s)- oxiracetam crystal form III for short) has diffraction peaks at diffraction angles 2θ, wherein the diffraction angles 2θ are equal to 10.54°, 13.70°, 14.44°, 15.60°, 17.12°, 18.88°, 19.24°, 20.66°, 20.84°, 21.18°, 21.82°, 22.94°, 23.24°, 24.88°, 27.20°, 27.48°, 28.24°, 30.46°, 30.80°, 31.52°, 32.00°, 32.34°, 32.90°, 33.20°, 34.40°, 34.62°, 37.30°, 37.50°, 38.28°, 38.96°, and 40.02°. The (S)-oxiracetam crystal form III of the present invention has an obvious effect on memory dysfunction, is dissolved in water fast, has high bioavailability, and can be used to prepare various pharmaceutical compositions. The (S)-oxiracetam crystal form III obtained by using the preparation method of the present invention is high in purity. The preparation method of the application of the present invention is performed in a mild condition, is easy in operation, introduces less impurities, has desirable reproducibility, is easily controlled during production, and is applicable to industrial production.
C07D 207/273 - Pyrrolidones-2 avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
44.
Use of levo-oxiracetam and oxiracetam in preparation of medicines for preventing or treating coma
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
The present invention is to provide uses of the L-oxiracetam in preparation of medicines for preventing or treating coma. Experimental results show that L-oxiracetam wake-promoting effects of alcoholism-induced coma is obvious, and D-oxiracetam has basically no effect. The effect of the above wake-promoting effects of L-oxiracetam is 2 times greater than racemic oxiracetam. The wake-promoting effects of L-oxiracetam on trauma or anesthesia-induced coma are both significant.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
45.
(S)-4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form II and preparation method therefor
An (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide racemate referred to as (S)-oxiracetam crystal form II has a diffraction peak at a diffraction angle 2θ of 10.669, 13.25, 13.847, 14.198, 16.729, 17.934, 18.746, 18.816, 20.273, 20.413, 21.431, 21.617, 21.663, 23.38, 24.324, 24.415, 26.069, 26.107, 27.901, 28.621, 28.925, 29.449, 29.484, 31.702, 36.516, 37.685, or 39.721 degrees. The purity of the (S)-oxiracetam crystal form II can be up to 98.5%, and the (S)-oxiracetam crystal form II has the advantages of simple preparation method, mild control condition, low production cost, and the produced oxiracetam hydrate crystal form II has a high purity (the oxiracetam hydrate crystal form having a purity of 8%˜98.5% can be prepared by a crude levo-oxiracetam having a purity of 92%, and thus having a good reproducibility in production.
C07D 207/273 - Pyrrolidones-2 avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
46.
Preparation method for medical porous tantalum implant material
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED (Chine)
Inventeur(s)
Ye, Lei
Abrégé
−3 Pa of vacuity and the temperature is first increased to 800-900° C. at a rate of 10-20° C./min and kept at 800-900° C. for 240-480 minutes, then is decreased to 400° C. at a rate of 2-5° C./min and kept at 400° C. for 120-300 minutes, and is cooled down to room temperature naturally in the furnace.
B23B 5/18 - Machines ou dispositifs à tourner spécialement conçus pour un travail particulierAccessoires correspondants spécialement conçus à cet effet pour tourner des vilebrequins, des excentriques ou des cames, p. ex. tours pour manetons de vilebrequins
B32B 5/18 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par le fait qu'une des couches contient un matériau sous forme de mousse ou essentiellement poreux
Disclosed is a 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I which is prepared by the following steps: dissolving crude 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate in a solvent such as a micromolecular alcohol to form a saturated solution; heating and stirring the solution overnight at 38˜42° C. to obtain a suspended precipitate; filtering and drying the solution to obtain a crystal. Such 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has a purity as high as 99.5%, which has significant treatment effect on curing respective diseases, and the 4-hydroxy-2-oxo-1-pyrrolidineacetamide racemate crystal form I has the features of simple manufacturing method, mild control condition, and low production cost, and its yield rate is as high as 99.5% which is applicable for mass production.
C07D 207/273 - Pyrrolidones-2 avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
A method for purifying (S)-oxiracetam is disclosed. Crude (S)-oxiracetam with the purity of 89% is dissolved in water; the solution is allowed to stand for 1 to 3 days at 0° C. to 18° C.; a colorless transparent crystal is precipitated; the solution is filtered and top-washed with cold water to 0° C. to 5° C.; and the product is dried in vacuum to obtain high-purity (S)-oxiracetam.
C07D 207/273 - Pyrrolidones-2 avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
A porous tantalum rod is provided, which is a medical implantation used for treating collapsed articular surface of the femoral head or necrosis of the femoral head in phase I or phase II. The implantation includes a fastening structure formed on one end of the porous tantalum rod used for connecting with the osseous tissues and a through hole formed on the center of the porous tantalum rod. The porous tantalum rod is made of the porous tantalum material, which is produced by foam impregnation and had a foam structure with three-dimensional interconnecting pores, wherein the foam structure has a foam skeleton, tantalum particles located on the foam skeleton, and multiple sintering neck structures formed between the tantalum particles.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A method for preparing a porous tantalum medical implant material comprises: directly performing selective laser sintering on a raw material, namely, pure tantalum powder with the particle size being less than or equal to 10 μm, so as to form a human bone metal biomimetic material, the thickness of powder paved on each layer during selective laser sintering being 60 to 80 μm; and sintering and cooling the formed human bone metal biomimetic material to obtain the porous tantalum medical implant material. Forming blank prepared by selective laser sintering is sintered and cooled so as to obtain the porous tantalum medical implant material of which pores are completely connected in a three-dimensional way and the structure is consistent with a microstructure of a bone tissue of a human body; the porous medical implant material is high in biocompatibility and biosecurity; and the method of the present invention also has the following advantages: process equipment is simple, operation cost is low, pollution is avoided in the whole preparation process, the toxic and side effects on the human body can be avoided, the biosecurity of the implant material can be guaranteed, the forming speed is high, and the porous tantalum medical implant material can be industrially produced and applied.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A method for preparing a biological medical porous implant material comprises: uniformly mixing pure tantalum powder and a binding agent to obtain tantalum powder slurry; placing in a steel die a high polymer resin template support which has the porosity of 20% to 50% and of which pores are completely connected in a three-dimensional way; pouring the prepared tantalum powder slurry into the steel die until the high polymer resin template support is immersed; slowly and uniformly applying pressure to the periphery of the steel die to ensure that the tantalum powder is fully and completely filled into the high polymer resin template support, the applied pressure being increased from 0 Mpa to 10 Mpa at a constant speed, and the time required by the pressure application process being 2 to 5 hours; performing chemical dissolution to remove the high polymer resin template support to obtain a green body framework of porous tantalum; and performing posttreatment such as degreasing and sintering to obtain the biological medical porous tantalum implant material. A product prepared by the method is a green body of the porous metal material of which pores are completely connected in the three-dimensional way, and the green body is sintered to form the porous metal implant material of which the pores are completely connected in the three-dimensional way, so that the porous metal implant material is high in biocompatibility.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A method for preparing a porous tantalum medical implant material comprises: feeding mixed tantalum power formed by mixing pure tantalum powder and a forming agent into a printing platform of a three-dimensional printer, and rolling and paving; a printing head of the three-dimensional printer spraying an adhesion agent to adhere the mixed tantalum powder so as to form a two-dimensional plane; descending a working table by 80 to 100 μm, and processing the next layer; accumulating and forming layer by layer; removing the tantalum powder particles which are not adhered to obtain an initially formed sample; and performing posttreatment such as degreasing, vacuum sintering, and cooling to obtain the porous tantalum medical implant material. The volume ratio of the pure tantalum powder to the forming agent is (60-80):(20-40), and the adhesion agent is alpha-cyanoacrylate adhesive in the mass percent of 1. The pores of the porous tantalum medical implant material prepared by the method are completely connected in a three-dimensional way; the porous tantalum medical implant material prepared by the method is high in biocompatibility, and meanwhile, has the mechanical property being consistent with that of weight-bearing bone tissues of a human body.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A method for preparing a porous tantalum medical implant material comprises: mixing a pure tantalum powder with a binding agent to obtain tantalum powder slurry; placing into a steel die a high polymer resin template support which has the porosity of 20% to 50% and is completely connected in a three-dimensional way; pouring the prepared tantalum powder slurry into the steel die and submerging the high polymer resin template support in the steel die; slowly and uniformly applying pressure at the periphery of the steel die so that the tantalum powder is completely and fully filled into the high polymer resin template support, the applied pressure being increased from 0 MPa to 8-12 MPa at a constant speed and the time required by the pressure application process being 2-5 h; performing chemical dissolution to remove the high polymer resin template support to obtain a green body framework of porous tantalum; and finally, performing posttreatment such as degreasing, sintering, and cooling to obtain a biomedical porous tantalum implant material. The prepared porous tantalum implant material has good biocompatibility and an excellent mechanical property.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
Provided in the present invention are the use of levo-oxiracetam in preparation of medicines for preventing or treating coma, and also medicines containing active ingredient oxiracetam or levo-oxiracetam and a pharmaceutically acceptable excipient.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
55.
PREPARATION METHOD FOR MEDICAL POROUS METAL MATERIAL FOR DENTAL BONE REPLACEMENT
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous metal material for dental bone replacement: mixing tantalum powder, a pore-forming agent, and a forming agent into a powder mixture, press-forming the powder into an organic foamed body, then degreasing, sintering, cooling, and performing a heating process to produce the porous tantalum material. The pressure used during the press-forming is 50 to 100 Mpa. The pore-forming agent is one of or a combination of urea, sodium chloride, ethyl cellulose, and methyl cellulose. The forming agent is one of or a combination of stearic acid, zinc stearate, paraffin, and synthetic rubber. Measurements show that the porous tantalum material prepared using the preparation method has an impurity concentration lower than 0.2%. The density reaches 11.67 to 13.34 g/cm3, the porosity reaches 20% to 30%, and the pore diameter reaches 5 to 30 μm. The elastic modulus reaches 4.5 to 6.0 Gpa, the bending strength reaches 110 to 130 Mpa, and the compressive strength reaches 100 to 130 Mpa. The porous tantalum prepared using the method is applicable as a medical implant material for dental bone replacement.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Jie, Yunfeng
Ye, Lei
Abrégé
A medical porous metal material for replacing tooth bone, obtained by the steps of: mixing tantalum powder, polyvinyl alcohol and sodium bicarbonate to form a mixed powder; compacting the mixed powder into an organic foam body and forming under 50-100Mpa; degreasing, sintering, cooling and thermal treatments; the sintering step specifically comprises: under 10-4Pa to 10-3Pa of vacuum pressure, heating to 1500-1800℃ at 10-20℃/min, maintaining the heat for 120-240min, cooling in a furnace to 200-300℃; then heating again to 1500-1800℃ at 10-20℃/min, maintaining the heat for 180-240min; and heating to 2000-2200℃ at 5-10℃/min, and maintaining the heat for 120-360min. The medical porous tantalum material formed has a pore diameter of 15-28μm, a porosity of 20-35%, a bending strength of 130-140Mpa, and a compressive strength of 140-170Mpa. The porous tantalum of the present invention is extraordinarily suitable to replace the tooth bone as a medical implant material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A medical porous metal material for weight-bearing bone tissue replacement and a preparation method therefor, prepared as follows: mixing tantalum powder, a pore-forming agent, and a forming agent, press-forming the powder mixture into an organic foamed body, then degreasing, sintering, cooling, and performing a heating process. The pressure used during the press-forming is 50 to 100 Mpa. The degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.3 to 2°C/min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 300 to 360 minutes. The pore-forming agent is ammonium bicarbonate or hydrogen peroxide. The forming agent is one or multiple of stearic acid, zinc sterate, paraffin, and synthetic resin. The medical porous tantalum material produced has a diameter of 100 to 500 μm, a porosity of 55% to 65%, an elastic modulus of 3.8 to 4.2 Gpa, and an elongation rate of 9.3% to 10.7%. The final porous tantalum material prepared using the preparation method of the present invention has a low impurity concentration, thereby effectively solving the conflict that the medical porous tantalum material for weight-bearing part replacement must have both high porosity and good mechanic properties.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Hao, Lina
Ye, Lei
Abrégé
A method for manufacturing a medical porous metal material for substituting of a load-bearing bone tissue. Tantalum powder, a pore-forming agent, and a molding agent are mixed, and then the powder mixture is compressed into an organic foam to undergo molding, degreasing, sintering, cooling, and heat treating. The degreasing is done by gradually heating to a temperature between 400°C and 800°C at a rate between 0.3°C/min and 2°C/min, argon is introduced to constitute a protective atmosphere, and kept warm for 300 min to 360 min. The sintering is done between 10-4 Pa and 10-3 Pa, heated to a temperature between 1500°C and 1800°C at a rate of 10 to 20°C/min, kept warm for 120 to 240 min, cooled along with a furnace to a temperature between 200°C and 300°C, then heated to a temperature between 1500°C and 1800°C at a rate of 10 to 20°C/min, kept warm for 180 to 240 min, heated to a temperature between 2000°C and 2200°C at a rate of 5 to 10°C/min, and kept warm for 120 to 360 min. Tests show an impurity content of less than 0.2%, a density between 5.00g/cm3 and 6.67g/cm3, a porosity between 60% and 70%, pore diameters between 200μm and 400μm, an elastic modulus between 3.8 and 4.2 GPa, a flexural strength between 120 MPa and 150 MPa, and a compressive strength between 72 MPa and 90 MPa. This effectively solves the contradiction between a requirement for increased porosity and that for great mechanical properties of the medical porous tantalum material as a substitute for load-bearing parts.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous tantalum material, characterized in that: mixing tantalum powder and an aqueous solution of polyvinyl alcohol into a slurry, injecting the slurry into an organic foamed body by using pressuring by vibration, then drying, degreasing, sintering, cooling, and performing a heating process to produce the medical porous tantalum material, the mass concentration of the aqueous solution of polyvinyl alcohol being 2% to 8%, and the vibration frequency being 20 to 80 times/minute. The porous tantalum prepared using the present invention is applicable as a medical implant material for weight-bearing bone tissue replacement, and ensures both biocompatibility and mechanic properties.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous tantalum material for human weight-bearing bone tissue replacement, comprising: mixing tantalum powder and an aqueous solution of polyvinyl alcohol into a slurry, injecting the slurry into an organic foamed body by using pressuring by vibration, then drying, degreasing, sintering, cooling, and performing a heating process to produce the medical porous tantalum material, the mass concentration of the aqueous solution of polyvinyl alcohol being 2% to 8%, and the vibration frequency being 20 to 80 times/minute. The sintering step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 120 to 240 minutes, cooling together with the furnace to 200 to 300°C, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 180 to 240 minutes, and increasing the temperature to 2000 to 2200°C at a speed of 5 to 10°C/min, and maintaining the temperature for 120 to 360 minutes. The porous tantalum prepared using the present invention is applicable as a medical implant material for weight-bearing bone tissue replacement, and ensures both biocompatibility and mechanic properties.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous tantalum material comprising mixing tantalum powder and an aqueous solution of polyglycolic into a slurry, injecting the slurry into an organic foamed body by using pressuring by vibration, then drying, degreasing, sintering, cooling, and performing a heating process; the mass concentration of the aqueous solution of polyglycolic is 2% to 8%, and the vibration frequency is 20 to 80 times/minute; the sintering step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 120 to 240 minutes, cooling together with the furnace to 200 to 300°C, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 180 to 240 minutes, increasing the temperature to 2000 to 2200°C at a speed of 5 to 10°C/min, and maintaining the temperature for 120 to 360 minutes; the heating process step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 800 to 900°C at a speed of 10 to 20°C/min, maintaining the temperature for 240 to 480 minutes, cooling to 400°C at a speed of 2 to 5°C/min, maintaining the temperature for 120 to 300 minutes, and cooling together with the furnace to room temperature. The porous tantalum prepared using the present method is suitable as a medical implant material for weight-bearing bone tissue replacement, and ensures both biocompatibility and mechanic properties.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A method for manufacturing a medical implant material porous tantalum. A slurry is made from aqueous polyvinyl alcohol and tantalum powder, then poured into an organic foam, soaked until pores in the organic foam are filled with the tantalum powder slurry, and dried for dehydration, and then a degreasing treatment is conducted under the protection of an inert gas to remove polyvinyl alcohol and the organic foam. A porous sintered body is acquired by sintering in vacuum, cooled, annealed in vacuum, and subjected to a regular post-processing to acquire porous tantalum. The sintering has the steps of: at a degree of vacuum between 10-4 Pa and 10-3 Pa, heated to 1800°C at a rate of 10°C/min, kept warm for 240 min, cooled along with a furnace to 300°C, then heated to 1800°C at a rate of 10°C/min, kept warm for 180 min, heated to a temperature between 2000°C and 2200°C at a rate of 10°C/min, and kept warm for 360 min. A heat processing is done at a degree of vacuum between 10-4 Pa and 10-3 Pa, heated to 800°C at a rate of 20°C/min, kept warm for 240 min, cooled to 400°C at a rate of 2°C/min, kept warm for 300 min, and then cooled with the furnace to room temperature. The porous tantalum material manufactured has great biocompatibility and safety, greatly increased strength in mechanical property, and is highly applicable for use in substituting bone tissues of load-bearing parts of the human body.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous metal implant material comprising mixing tantalum powder, a pore-forming agent, and a forming agent into a powder mixture, then granulating, injecting into a mold for forming, demolding, degreasing, sintering, and performing a heating process to produce the medical porous metal implant material for dental bone tissue replacement; the pore-forming agent is one or multiple of sodium bicarbonate, urea, sodium chloride, methyl cellulose, and ethyl cellulose, and the forming agent is one or multiple of polyvinyl alcohol, stearic acid, zinc stearate, paraffin, and synthetic rubber; the degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.5 to 3°C/min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 60 to 240 minutes. Measurements show that the porous tantalum material prepared using the method has an impurity concentration lower than 0.2%. The density reaches 11.67 to 13.34 g/cm3, the porosity reaches 20% to 30%, and the pore diameter reaches 12 to 25 μm. The elastic modulus reaches 4.5 to 6.0 Gpa, the elongation rate reaches 12.0% to 13.8%, the bending strength reaches 120 to 150 Mpa, and the compressive strength reaches 90 to 110 Mpa.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a porous tantalum for human dental bone tissue replacement produced by mixing tantalum powder, a pore-forming agent, a forming agent into a powder mixture, granulating, injecting into a mold for forming, then demolding, degreasing, sintering, and performing a heating process; the pore-forming agent is one or multiple of sodium bicarbonate, urea, sodium chloride, methyl cellulose, and ethyl cellulose, and the forming agent is one or multiple of polyvinyl alcohol, stearic acid, zinc stearate, paraffin, and synthetic rubber; the degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.5 to 3°C/min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 60 to 240 minutes; the sintering step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 120 to 240 minutes, cooling together with the furnace to 200 to 300°C, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 180 to 240 minutes, increasing the temperature to 2000 to 2200°C at a speed of 5 to 10°C/min, and maintaining the temperature for 120 to 360 minutes. The porous tantalum produced is very suitable as a medical implant material for human dental bone tissue replacement.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous metal implant material comprising mixing tantalum powder, a pore-forming agent, and a forming agent into a powder mixture, then granulating, injecting into a mold for forming, demolding, degreasing, sintering, and performing a heating process to produce the medical porous metal implant material for dental bone tissue replacement; the pore-forming agent is one or multiple of sodium bicarbonate, urea, sodium chloride, methyl cellulose, and ethyl cellulose, and the forming agent is one or multiple of polyvinyl alcohol, stearic acid, zinc stearate, paraffin, and synthetic rubber; the degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.5 to 3°C/min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 60 to 240 minutes; Effective improvements to the sintering and heating process steps substantially enhance the mechanic properties of the produced porous tantalum material, thereby enabling the material to be very suitable as a medical implant material for human dental bone tissue replacement.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A medical porous tantalum material for dental bone replacement and preparation method therefor, produced as follows: mixing tantalum powder, polyvinyl alcohol, and sodium bicarbonate into a powder mixture, press-forming the powder mixture into an organic foamed body, then degreasing, sintering, cooling, and performing a heating process. The pressure used during the press-forming is 50 to 100 Mpa. The diameter of the produced medical porous tantalum material pores is 30 to 50 μm. The porosity is 30% to 38%. The porous tantalum method of the present invention uses a purely physical molding method, so that the final porous tantalum material contains low concentration of impurities, thereby effectively enhancing the biocompatibility and biosafety. Measurements show that the impurity concentration is lower than 0.2%. The density reaches 10.34 to 11.67 g/cm3, the porosity reaches 30% to 38%, and the pore diameter reaches 30 to 50 μm. The elastic modulus reaches 4.5 to 6.0 Gpa, the bending strength reaches 120 to 130 Mpa, and the compressive strength reaches 100 to 140 Mpa. The porous tantalum of the present invention is applicable as a medical implant material for dental bone replacement.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A medical porous metal material for dental bone replacement and preparation method therefor, produced as follows: mixing tantalum powder, polyvinyl alcohol, and sodium bicarbonate into a powder mixture, press-forming the powder mixture into an organic foamed body under 50 to 100 Mpa, then degreasing, sintering, cooling, and performing a heating process. The heating process step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 800 to 900°C at a speed of 10 to 20°C/min, maintaining the temperature for 240 to 480 minutes, cooling to 400°C at a speed of 2 to 5°C/min, maintaining the temperature for 120 to 300 minutes, and cooling together with the furnace to room temperature. The medical porous tantalum material produced has a diameter of 10 to 25 μm, a porosity of 25% to 35%, an elastic modulus of 6.0 to 7.0 Gpa, and an elongation rate of 14% to 15%.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Hao, Lina
Ye, Lei
Abrégé
A method for manufacturing a medical porous metal material. Tantalum powder, polyvinyl alcohol, and sodium hydrogen carbonate are mixed to form a powder mixture, then, same is compressed at 50 to 100 MPa into an organic foam to undergo the processes of molding, degreasing, sintering, cooling, and heat treating to acquire a porous tantalum material. The sintering is done with a degree of vacuum between 10-4 Pa and 10-3 Pa, heated to a temperature between 1500°C and 1800°C at a rate of 10 to 20°C/min, kept warm for 120 to 240 min, cooled along with a furnace to between 200°C and 300°C, heated to a temperature between 1500°C and 1800°C at a rate of 10 to 20°C/min, kept warm for 180 to 240 min, and heated to a temperature between 2000°C and 2200°C at a rate of 5 to 10°C/min. The heat treating is done with a degree of vacuum between 10-4 Pa and 10-3 Pa, heated to a temperature between 800°C and 900°C at a rate of 10 to 20°C/min, kept warm for 240 to 480 min, then cooled to 400°C at a rate of 2 to 5°C/min, kept warm for 120 to 300 min, and then cooled along with the furnace to room temperature. Tests show that the material is provided with an impurity content of less than 0.2%, a porosity between 30% and 38%, pore diameters between 30μm and 50μm, an elastic modulus between 6.0 GPa and 7.0 GPa, a compressive strength between 150 MPa and 170 MPa, and is highly applicable for use in a dental bone-substituting medical implant material.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous metal material for weight-bearing bone tissue replacement comprising: mixing tantalum powder, a pore-forming agent, and a forming agent, press-forming the powder mixture into an organic foamed body, then degreasing, sintering, cooling, and performing a heating process. The pressure during the press-forming is 50 to 100 Mpa. The degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.3 to 2°C/min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 300 to 360 minutes. The pore-forming agent is ammonium bicarbonate or hydrogen peroxide. The forming agent is one or multiple of stearic acid, zinc sterate, paraffin, and synthetic resin. Within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 800 to 900°C at a speed of 10 to 20°C/min, maintaining the temperature for 240 to 480 minutes, cooling to 400°C at a speed of 2 to 5°C/min, maintaining the temperature for 120 to 300 minutes, and cooling together with the furnace to room temperature. Measurements show that the impurity concentration thereof is lower than 0.2%. The density reaches 6.67 to 8.34 g/cm3, the porosity reaches 50% to 60%, and the pore diameter reaches 150 to 450 μm. The elastic modulus reaches 4.5 to 6.0 Gpa, and the bending strength reaches 100 to 120 Mpa.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Jie, Yunfeng
Ye, Lei
Abrégé
A method for producing a medical porous metallic material as alternative to load-bearing bone tissue comprises: mixing tantalum powder with ammonium bicarbonate or hydrogen peroxide and forming agent (one or more of stearic acid, zinc stearate, paraffin wax and synthetic resin), then forming by pressing, degreasing, sintering, cooling and heat treating. The step of forming by pressing is pressing the mixture into a polymeric sponge under a pressure of 50 to 100MPa. The degreasing is gradually heating to 400 to 800℃ with a heating rate of 0.3℃/min to 2℃/min under argon gas as protective atmosphere and keeping at the temperature for 300 min to360 min. The sintering comprises heating to 1500 to 1800℃ with a heating rate of 10 to 20℃/min under a vacuum of 10-4Pa to 10-3Pa, keeping at the temperature for 120 to 240min, cooling to 200 to 300℃ in furnace, then heating to 1500 to1800℃ with a heating rate of 10 to 20℃/min, keeping at the temperature for 180 to 240min, heating to 2000 to 2200℃ with a rate of 5 to 10℃/min and keeping at the temperature for 120 to 360 min. The method can effectively solve the contradiction between requirement of large porosity and requirement of good mechanical properties required by medical porous tantalum material as alternative to load-bearing part. The material is very suitable for being used as medical implant material as alternative to load-bearing bone tissue.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous tantalum implant material, comprising mixing tantalum powder and an aqueous solution of polyvinyl alcohol into a slurry, injecting the slurry into an organic foamed body by using pressuring by vibration, then drying, degreasing, sintering, cooling, and performing a heating process to produce the medical porous tantalum material. The porous tantalum is suitable as a medical implant material for weight-bearing bone tissue replacement, and ensures both biocompatibility and mechanic properties. The residue-less reagent and organic foamed body ensure good biosafety.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous tantalum implant material, comprising using tantalum powder and a solution prepared with an organic adhesive agent and a dispersant agent to produce a tantalum powder slurry, casting the slurry into an organic foamed body, keeping immersed till the pores of the organic foamed body are filled completely with the tantalum powder slurry, drying to remove the dispersant agent in the organic foamed body into which the tantalum powder slurry is cast, performing a degreasing process to remove the organic adhesive agent and the organic foamed body within an inert gas protective atmosphere, sintering within a vacuum to produce a porous sintered body, cooling, vacuum-annealing, and performing conventional post-processing to produce the porous tantalum; the sintering step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 120 to 240 minutes, cooling together with the furnace to 200 to 300°C, increasing the temperature to 1500 to 1800°C at a speed of 10 to 20°C/min, maintaining the temperature for 180 to 240 minutes, increasing the temperature to 2000 to 2200°C at a speed of 5 to 10°C/min, and maintaining the temperature for 120 to 360 minutes. The porous tantalum material prepared using the present invention has good biocompatibility, safety, and highly strong mechanic properties, and is very suitable for bone tissue replacement of human weight-bearing parts.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous tantalum implant material sintered using the foam immersing method. Using tantalum powder and a solution prepared with an organic adhesive agent and a dispersant agent to produce a tantalum powder slurry, casting the slurry into an organic foamed body, keeping immersed till the pores of the organic foamed body are filled completely with the tantalum powder slurry, drying to remove the dispersant agent in the organic foamed body into which the tantalum powder slurry is cast, performing a degreasing process to remove the organic adhesive agent and the organic foamed body within an inert gas protective atmosphere, sintering within a vacuum to produce a porous sintered body, cooling, vacuum-annealing, and performing conventional post-processing to produce the porous tantalum; the heating process comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 800 to 900°C at a speed of 10 to 20°C/min, maintaining the temperature for 240 to 480 minutes, cooling to 400°C at a speed of 2 to 5°C/min, maintaining the temperature for 120 to 300 minutes, and cooling together with the furnace to room temperature. The porous tantalum material prepared using the present invention has good biocompatibility, safety, and highly strong mechanic properties, and is very suitable for bone tissue replacement of human weight-bearing parts.
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED. (Chine)
Inventeur(s)
Ye, Lei
Abrégé
A preparation method for a medical porous metal implant material comprising mixing tantalum powder, a pore-forming agent, and a forming agent into a powder mixture, then granulating, injecting into a mold for forming, demolding, degreasing, sintering, and performing a heating process to produce the medical porous metal implant material for dental bone tissue replacement; the pore-forming agent is one or multiple of sodium bicarbonate, urea, sodium chloride, methyl cellulose, and ethyl cellulose, and the forming agent is one or multiple of polyvinyl alcohol, stearic acid, zinc stearate, paraffin, and synthetic rubber; the degreasing process comprises: gradually increasing the temperature to 400 to 800°C at a speed of 0.5 to 3°C/min, introducing argon gas to form a protective atmosphere, and maintaining the temperature for 60 to 240 minutes; the heating process step comprises: within a vacuum degree of 10-4 to 10-3 Pa, increasing the temperature to 800 to 900°C at a speed of 10 to 20°C/min, maintaining the temperature for 240 to 480 minutes, cooling to 400°C at a speed of 2 to 5°C/min, maintaining the temperature for 120 to 300 minutes, and cooling together with the furnace to room temperature. The porous tantalum produced is very suitable as a medical implant material for dental bone tissue replacement.
A crystal form I of (S)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, or named (S)-oxiracetam, is provided, which is characterized by a powder x-ray diffraction pattern that exhibits data of d-values versus the relative intensities as: 7.075(M), 5.355(S), 5.092(S), 4.590(M), 4.325(M), 4.259(S), 4.041(VS), 3.808(M), 3.542(M), 3.445(M), 3.393(M), 2.972(M), 2.914(S). A method for preparing a crystal form I of (S)-oxiracetam is also provided, which includes preparing the crude product and crystallizing A use of the crystal form I of (S)-oxiracetam in the manufacture of a medicament for preventing and treating memory dysfunction is also provided. Accordingly, the crystal form I of (S)-oxiracetam prepared by the method has high purity of more than 99.3% based on the percentages of the mass, with better efficacy than (S)-oxiracetam for preventing or treating memory dysfunction. Concerning the way of charging materials, adding inorganic base only a few times is simpler and more beneficial to industrial manufacturing and application.
C07D 207/273 - Pyrrolidones-2 avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
CHONGQING RUNZE PHARMACEUTICAL COMPANY LIMITED (Chine)
Inventeur(s)
Ye, Lei
Rong, Zuyuan
Abrégé
A method for purifying levo-oxiracetam. Crude levo-Oxiracetam is dissolved in water, an organic solvent is dropwise added into the solution until the solution just turns turbid, the solution is then allowed to stand for 1 to 3 days at 0°C to 18°C, and a colorless transparent crystal is precipitated; the solution is filtered and top-washed with cold water of 0°C to 5°C; the product is dried in vacuum to obtain high-purity levo-oxiracetam.
C07D 207/273 - Pyrrolidones-2 avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
A medical implant-porous tantalum rod used in the case of the collapse of the articular surface of the femoral head or for femoral head necrosis in stages I or II. One end of the implant is provided with a fastening structure for connecting to osseous tissue, the centre thereof having a through hole (3). The porous tantalum material employed in the porous tantalum rod has a foam structure with a three-dimensional connected pore distribution, and is made by sintering in a foam steeping process; on the foam framework formed by the accumulation of a sintered pure tantalum powder, the tantalum powder particles have a sintered neck structure among them. The through hole (3) in the porous tantalum rod is convenient for accurate location in surgery, and is also convenient for extraction or injection of associated things, thus achieving the effect of continuous decompression.
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