Isolated Rhodococcus ruber, a product derived from the Rhodococcus ruber (in particular, a product derived from the Rhodococcus ruber cell wall), a method for preparing the product derived from the Rhodococcus ruber, and use of the product derived from the Rhodococcus ruber in prevention and/or treatment of lichen planus. The product derived from the Rhodococcus ruber effectively reduce the erosion area of lichen planus and relieve pain.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 31/20 - Antiviraux pour le traitement des virus ADN
The present disclosure relates to a use of Nocardia rubra cell wall skeleton in regenerative medicine, and in particular, to a use of Nocardia rubra (especially the cell wall skeleton thereof) in the following aspects: promoting proliferation, growth, differentiation and migration of stem cells, and improving the survival rate of the stem cells, wherein the stem cells are selected from: adult stem cells, iPSCs, and mesenchymal stem cells.
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61K 35/36 - PeauSystème pileuxOnglesGlandes sébacéesCérumenÉpidermeCellules épithélialesKératinocytesCellules de LangerhansCellules ectodermiques
3.
Rhodococcus ruber cell wall skeleton in regenerative medicine
Rhodococcus ruber cell wall skeleton in promoting the proliferation of stem cells, promoting the growth of stem cells, promoting the differentiation of stem cells, promoting the migration of stem cells, and improving the survival rate of stem cells; the stem cells are selected from: adult stem cells, iPSCs, and mesenchymal stem cells.
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
The use of a Rhodococcus ruber product in the treatment of radiation sickness. Specifically, provided is a Rhodococcus ruber product containing the cell wall of Rhodococcus ruber or a component thereof, which can be used for effectively treating or alleviating radiation sickness and the symptoms thereof.
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61P 39/00 - Agents protecteurs généraux ou antipoisons
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
5.
USE OF NOCARDIA RUBRA CELL WALL SKELETON IN TREATMENT OF RADIATION SICKNESS
The use of Nocardia rubra cell wall skeleton in treatment of a radiation sickness. A pharmaceutical composition comprising a component derived from the Nocardia rubra cell wall, which is effective in treating or relieving the radiation sickness and its symptoms.
Rhodococcus ruber was stored and preserved at China General Microbiological Culture Collection Center, No. 1, West Beichen Road, Chaoyang District, Beijing on Mar. 22, 2019 with accession number CGMCC 17431.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 31/20 - Antiviraux pour le traitement des virus ADN
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61P 31/20 - Antiviraux pour le traitement des virus ADN
The present disclosure relates to a use of Nocardia rubra cell wall skeleton in regenerative medicine, and in particular, to a use of Nocardia rubra (especially the cell wall skeleton thereof) in the following aspects: promoting proliferation, growth, differentiation and migration of stem cells, and improving the survival rate of the stem cells, wherein the stem cells are selected from: adult stem cells, iPSC, and mesenchymal stem cells.
Provided is a use of a Rhodococcus ruber cell wall skeleton in promoting the proliferation of stem cells, promoting the growth of stem cells, promoting the differentiation of stem cells, promoting the migration of stem cells, and improving the survival rate of stem cells; the stem cells are selected from: adult stem cells, iPSCs, and mesenchymal stem cells.
A use of a cell wall or a cell wall skeleton of Rhodococcus ruber in preparing a drug for treating a thermal injury. The thermal injury comprises a burn, a scald and a chemical burn. Applying the Rhodococcus ruber product to a subject has a good therapeutic effect on a thermal injury and has no side effects.
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
12.
USE OF NOCARDIA RUBRA CELL WALL SKELETON IN TREATMENT OF THERMAL INJURY
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
13.
USE OF NOCARDIA RUBRA CELL WALL SKELETON IN TREATING WHITE LESIONS ON VULVA
Provided is the use of Nocardia rubra cell wall skeleton in treating white lesions on the vulva. Provided is a pharmaceutical composition, wherein same comprises a component derived from a Nocardia rubra cell wall, and can effectively treat white lesions on the vulva, including lichen sclerosus and squamous cell hyperplasia.
A61K 8/99 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de micro-organismes autres que des algues ou des champignons, p. ex. à base de protozoaires ou de bactéries
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
A use of a Rhodococcus ruber product in the treatment of vulvar white lesions. Provided is a Rhodococcus ruber product containing Rhodococcus ruber cell walls or components thereof. When administered to a subject, the Rhodococcus ruber product has a good treatment effect on vulvar white lesions (comprising lichen sclerosus and squamous cell hyperplasia), and has no side effects.
A use of an isolated rhodococcus ruber cell wall skeleton or a composition containing same in preparing a medicament for treating cervical erosion. The rhodococcus ruber cell wall skeleton being isolated from rhodococcus ruber deposited in the China General Microbiological Culture Collection Center at 1 West Beichen Road, Chaoyang District, Beijing, #3 on 22 March 2019, having a deposit number of CGMCC 17431.
The present disclosure relates to use of a Rhodococcus ruber product in treating diseases caused by Candida albicans infections. Specifically, the present disclosure provides a Rhodococcus ruber product comprising cell walls of Rhodococcus ruber or components thereof. The administration of the Rhodococcus ruber product to a subject can effectively alleviate the diseases and symptoms caused by Candida albicans infections. The diseases caused by Candida albicans infections comprise genital diseases caused by Candida albicans infections, oral mucosal diseases caused by Candida albicans infections, skin diseases caused by Candida albicans infections, and gastrointestinal diseases caused by Candida albicans infections.
C12P 1/04 - Préparation de composés ou de compositions, non prévue dans les groupes , utilisant des micro-organismes ou des enzymesProcédés généraux de préparation de composés ou de compositions utilisant des micro-organismes ou des enzymes utilisant des bactéries
17.
PRODUCT DERIVED FROM RHODOCOCCUS RUBER, AND PHARMACEUTICAL USE THEREOF
Isolated Rhodococcus ruber, a product derived from the Rhodococcus ruber (in particular, a product derived from the Rhodococcus ruber cell wall), a method for preparing the product derived from the Rhodococcus ruber, and use of the product derived from the Rhodococcus ruber in prevention and/or treatment of lichen planus. The product derived from the Rhodococcus ruber effectively reduce the erosion area of lichen planus and relieve pain.
Disclosed is the use of a Rhodococcus ruber product in the treatment of a recurrent aphthous ulcer. The recurrent aphthous ulcer is selected from any one of or a combination of: mild recurrent aphthous ulcers, herpetic recurrent aphthous ulcers and severe recurrent aphthous ulcers. After drug administration, it can be seen that ulcer healing, hyperemia and pain symptoms disappear.
The present disclosure relates to the use of Rhodococcus ruber products in the treatment of skin damage or ulcers of warm-blooded animals. Specifically, provided in the present disclosure is a Rhodococcus ruber product containing the Rhodococcus ruber cell wall or the components thereof. Administration of the present Rhodococcus ruber product to a subject has good effects for the treatment of skin ulcers and skin damage caused by physical or chemical factors without side effects, and promotes skin tissue repair.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
20.
USE OF CELL WALL SKELETON OF ISOLATED RHODOCOCCUS RUBER FOR PREPARING HUMAN PAPILLOMAVIRUS INFECTION TREATMENT DRUG
Disclosed is a use of a cell wall skeleton of isolated Rhodococcus ruber or a composition containing the same for preparing a human papillomavirus infection treatment drug. The cell wall skeleton of Rhodococcus ruber isolated from Rhodococcus ruber was stored and preserved at China General Microbiological Culture Collection Center, No.1, West Beichen Road, Chaoyang District, Beijing on March 22, 2019 with accession number CGMCC 17431.
An isolated Rhodococcus ruber cell wall skeleton, a composition comprising said cell wall skeleton, and use of said cell wall skeleton in preparation of a medicament for treating human cervical precancerous lesions. The Rhodococcus ruber is the one deposited in General Microbiological Culture Collection Center of China Committee for Culture Collection of Microorganisms, Building 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing on 22 March 2019, and has a deposit number of CGMCC 17431.
Disclosed are a separated Rhodococcus ruber cell wall skeleton, a compound containing the cell wall skeleton, and use of the cell wall skeleton in preparation of medicine for treatment of human herpes simplex and/or herpes zoster. The described Rhodococcus ruber is preserved on March 22, 2019 at China General Microbiological Culture Collection Center at No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing, the preservation serial number is CGMCC 17431.
Disclosed is the use of a Nocardia rubra cell wall skeleton in the treatment of a recurrent aphthous ulcer. The recurrent aphthous ulcer is selected from any one of or a combination of the following: a mild recurrent aphthous ulcer, a herpetic recurrent aphthous ulcer and a severe recurrent aphthous ulcer. It can be seen that after drug administration, ulcer healing, hyperemia and pain symptoms all disappear.
The present application relates to a use of red Nocardia cell wall skeleton for preparing a pharmaceutical for treating lichen planus. Specifically disclosed is: a red Nocardia cell wall skeleton effectively reduces the eroded area of lichen planus, reducing the pain level, and after use, exhibits good therapeutic efficacy. In the first report of the present application, the cell wall skeleton of Nocardia red is used to treat erosive oral lichen planus, and its efficacy and safety has been preliminarily observed.
A61K 35/66 - Micro-organismes ou substances provenant de micro-organismes
A01N 63/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des micro-organismes, des virus, des champignons microscopiques, des animaux ou des substances produites par, ou obtenues à partir de micro-organismes, de virus, de champignons microscopiques ou d'animaux, p. ex. enzymes ou produits de fermentation
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