Abrégé

A system comprises a plurality of user adjustable rules that allows a user to customize when a sample such as a peripheral blood smear is flagged for morphological review by a person and when an automated review of the sample is sufficient. The user adjustable rules allow a user to set rules that are appropriate for a healthcare provider to improve the work-flow and allows the user better control of the balance between automation of the sample review and manual review of the sample such as a peripheral blood smear. The user adjustable rules may comprise a set of values, such as thresholds or ranges for cell types, which may result in the sample being either flagged or not flagged for morphological review by a specialist such as a pathologist.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G06V 10/74 - Appariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques
• G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
• G06V 10/94 - Architectures logicielles ou matérielles spécialement adaptées à la compréhension d’images ou de vidéos
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients

Abrégé

An apparatus configured to process a sample to detect a pathogen receives a slide with the sample on the slide, in which the sample has been stained with one or more of a Gram stain, an Acid-Fast stain, or a Giemsa stain. An area of at least 5 mm2 of the sample is imaged at a rate of at least 15 mm2 per minute and a resolution of 0.3 pm or better to generate one or more images. The one or more images of the sample are processed with a classifier configured to detect the pathogen in the sample. In some embodiments, a plurality of cultured and stained samples on a plurality of slides are imaged at the resolution and processed with the classifier, which can increase the area processed and analyzed in order to decrease the culture time and corresponding time to diagnose the patient.

Classes IPC  ?

• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G16H 10/40 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données relatives aux analyses de laboratoire, p. ex. pour des analyses d’échantillon de patient

Abrégé

A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• G02B 21/00 - Microscopes
• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope

Abrégé

A microscope system may be integrated with a coverslipping device. A method of preparing a microscope slide for imaging a sample on the microscope slide may include placing a transparent flowable material on the sample while the slide is supported with one or more linkages coupled to a processor, covering the sample with a coverslip, and placing the microscope slide on a microscope stage with the one or more linkages coupled to the slide and the processor. Various other systems and methods are provided.

Classes IPC  ?

• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• G01N 1/30 - TeintureImprégnation

Abrégé

A microscope comprising an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample comprising artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that comprises artifacts or empty space. The imaging process may comprise a higher resolution process to output higher resolution portions of the computational image for sample regions comprising valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions comprising valid sample material.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/00 - Microscopes
• G02B 21/12 - Condensateurs donnant un éclairage sur fond clair

Abrégé

Methods of predicting the response of a subject to chimeric antigen receptor (CAR) therapy comprising receiving peripheral blood smears (PBS) from the subject and determining the number of CAR cells in the PBS are provided.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 1/30 - TeintureImprégnation

Abrégé

A slide transfer device is configured to transfer a plurality of slides from a first container to a second container, which can improve compatibility between slide preparation devices and microscopes. The first container is configured to receive slides from a slide preparation device, and the second container is configured to provide slides to a slide loader of a microscope. The first container may not be compatible with the microscope slide loader. The first container may differ from the second container by one or more of a maximum distance across, a slide capacity, a number of slide receptacles, a distance between slide receptacles, or a size of slide receptacles. The plurality of slides comprises a first orientation and a first order in the first container and the slide transfer device is configured to provide the plurality of slides to the second container with a second orientation or a second order.

Classes IPC  ?

• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• G02B 21/02 - Objectifs
• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope

Abrégé

A microscope system for full field morphology analysis may include an optical scanning apparatus to scan the sample with an effective numerical aperture of at least 0.8, and a processor coupled to the scanning apparatus. The processor may be configured to: scan the sample with the optical scanning apparatus to produce a plurality of images of the sample, the plurality of images comprising at least 500 blood cells, analyze the plurality of images to determine at least 10 morphology parameters for each of the at least 500 blood cells, and output the at least 10 morphology parameters. The microscope system may include a display for presenting data. Various other systems and methods are provided.

Classes IPC  ?

• G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
• G06T 7/00 - Analyse d'image
• G06T 3/40 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G02B 21/00 - Microscopes

Abrégé

A microscope system for detecting a scan area within hematology slides in digital microscopy may include a scanning apparatus to scan a hematology sample, and a processor coupled to the scanning apparatus and a memory. The processor may be configured to execute instructions which may cause the system to receive a first image of the sample at a first resolution and determine a scan area of the sample to scan in response to the first image. The instructions may further cause the system to scan the scan area to generate an image of the scan area at a second resolution greater than the first resolution and classify a plurality of cells from the image of the scan area into cell data comprising a plurality of cell parameters. The instructions may also cause the microscope system to output the cell data. Various other systems and methods are provided.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G01N 15/05 - Recherche de la sédimentation des suspensions de particules dans du sang

Abrégé

A system comprises a plurality of user adjustable rules that allows a user to customize when a sample such as a peripheral blood smear is flagged for morphological review by a person and when an automated review of the sample is sufficient. The user adjustable rules allow a user to set rules that are appropriate for a healthcare provider to improve the work- flow and allows the user better control of the balance between automation of the sample review and manual review of the sample such as a peripheral blood smear. The user adjustable rules may comprise a set of values, such as thresholds or ranges for cell types, which may result in the sample being either flagged or not flagged for morphological review by a specialist such as a pathologist.

Classes IPC  ?

• G06T 7/00 - Analyse d'image
• G01N 1/28 - Préparation d'échantillons pour l'analyse
• G01N 15/10 - Recherche de particules individuelles

Abrégé

An apparatus configured to process a sample to detect a pathogen receives a slide with the sample on the slide, in which the sample has been stained with one or more of a Gram stain, an Acid-Fast stain, or a Giemsa stain. An area of at least 5 mm2of the sample is imaged at a rate of at least 15 mm2 per minute and a resolution of 0.3 pm or better to generate one or more images. The one or more images of the sample are processed with a classifier configured to detect the pathogen in the sample. In some embodiments, a plurality of cultured and stained samples on a plurality of slides are imaged at the resolution and processed with the classifier, which can increase the area processed and analyzed in order to decrease the culture time and corresponding time to diagnose the patient.

Classes IPC  ?

• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• G01B 11/02 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur

Abrégé

A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.

Classes IPC  ?

• G02B 21/26 - PlatinesMoyens de réglage pour celles-ci
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• G02B 21/00 - Microscopes

Abrégé

A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G01B 11/06 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur pour mesurer l'épaisseur
• G01B 11/22 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la profondeur
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G06V 10/56 - Extraction de caractéristiques d’images ou de vidéos relative à la couleur
• G06V 10/141 - Commande d’éclairage
• G06V 20/64 - Objets tridimensionnels

Abrégé

A microscope system for scanning a bone marrow aspirate (BMA) sample may include a scanning apparatus for scanning the BMA sample and a processor coupled to the scanning apparatus and a memory. The microscope system may obtain, using the scanning apparatus, scan data of the BMA sample and detect cells in the BMA sample from the scan data. The microscope system may also classify the detected cells into a plurality of cell types, and store, in the memory, cell data of the classified cells. The microscope system may include a display for presenting the cell data. Various other systems and methods are provided.

Classes IPC  ?

• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G06K 9/62 - Méthodes ou dispositions pour la reconnaissance utilisant des moyens électroniques
• G06V 10/22 - Prétraitement de l’image par la sélection d’une région spécifique contenant ou référençant une formeLocalisation ou traitement de régions spécifiques visant à guider la détection ou la reconnaissance
• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Produits et services

Recorded software embedded in microscopy systems for use in scanning, analyzing, and quantifying large areas of biological samples containing multiple cells at high resolution and generating reports useful in the detection, diagnosis and monitoring of disease and medical conditions.

Produits et services

Recorded software embedded in microscopy systems for use in scanning, analyzing, and quantifying large areas of bone marrow at high resolution.

Produits et services

Digital microscopy system consisting of a scanner, camera, embedded recorded software, slide loader and slide tray for analysis of hematology samples.

Produits et services

Recorded software embedded in microscopy systems for use in scanning, analyzing, and quantifying large areas of blood cells at high resolution and generating reports useful in the detection of cancers, blood-related conditions and disease monitoring.

Produits et services

Recorded software embedded in microscopy systems for use in scanning, analyzing, and quantifying large areas of blood cells at high resolution and generating reports useful in the detection of cancers, blood-related conditions and disease monitoring.

Abrégé

A microscope system may be integrated with a coverslipping device. A method of preparing a microscope slide for imaging a sample on the microscope slide may include placing a transparent flowable material on the sample while the slide is supported with one or more linkages coupled to a processor, covering the sample with a coverslip, and placing the microscope slide on a microscope stage with the one or more linkages coupled to the slide and the processor. Various other systems and methods are provided.

Classes IPC  ?

• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G01N 1/28 - Préparation d'échantillons pour l'analyse

Produits et services

Recorded software embedded in microscopy systems for use in scanning, analyzing, and quantifying large areas of blood cells at high resolution.

Abrégé

A microscope including an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample including artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that includes artifacts or empty space. The imaging process may include a higher resolution process to output higher resolution portions of the computational image for sample regions including valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions including valid sample material.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/00 - Microscopes
• G02B 21/12 - Condensateurs donnant un éclairage sur fond clair

Produits et services

(1) Digital microscopy system consisting of a scanner, camera, embedded recorded software, slide loader and slide tray for analysis of hematology samples.

Produits et services

(1) Recorded software embedded in microscopy systems for use in scanning, analyzing, and quantifying large areas of blood cells at high resolution and generating reports useful in the detection of cancers, blood-related conditions and disease monitoring.

Abrégé

A microscope system for detecting a scan area within hematology slides in digital microscopy may include a scanning apparatus to scan a hematology sample, and a processor coupled to the scanning apparatus and a memory. The processor may be configured to execute instructions which may cause the system to receive a first image of the sample at a first resolution and determine a scan area of the sample to scan in response to the first image. The instructions may further cause the system to scan the scan area to generate an image of the scan area at a second resolution greater than the first resolution and classify a plurality of cells from the image of the scan area into cell data comprising a plurality of cell parameters. The instructions may also cause the microscope system to output the cell data. Various other systems and methods are provided.

Classes IPC  ?

• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G06F 3/0484 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] pour la commande de fonctions ou d’opérations spécifiques, p. ex. sélection ou transformation d’un objet, d’une image ou d’un élément de texte affiché, détermination d’une valeur de paramètre ou sélection d’une plage de valeurs
• G06T 3/40 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement

Abrégé

A microscope system for full field morphology analysis may include an optical scanning apparatus to scan the sample with an effective numerical aperture of at least 0.8, and a processor coupled to the scanning apparatus. The processor may be configured to: scan the sample with the optical scanning apparatus to produce a plurality of images of the sample, the plurality of images comprising at least 500 blood cells, analyze the plurality of images to determine at least 10 morphology parameters for each of the at least 500 blood cells, and output the at least 10 morphology parameters. The microscope system may include a display for presenting data. Various other systems and methods are provided.

Classes IPC  ?

• G06T 7/00 - Analyse d'image

Produits et services

Recorded software for use in scanning, uploading, reading, viewing, processing, and storing digital cytology and hematology in the nature of bone marrow slide images, embedded in digital microscopes, computers, illumination systems and cameras as the primary components of microscopy systems, also comprised of motors, lenses, illumination device, cameras, printed circuit boards, computer processor and memory

Produits et services

Recorded software for use in scanning, uploading, reading, viewing, processing, and storing digital cytology and hematology in the nature of blood cell slide images, embedded in digital microscopes, computers, illumination systems and cameras as the primary components of microscopy systems, also comprised of motors, lenses, illumination device, cameras, printed circuit boards, computer processor and memory

Produits et services

recorded software for use in scanning, analyzing, and quantifying large areas of blood cells at high resolution and generating reports useful in the detection of cancers, blood-related conditions and disease monitoring, embedded in digital microscopes, computers, and cameras as the primary components of microscopy systems, also compromised of motors, lenses, illumination device, cameras, printed circuit boards, computer processor and memory

Produits et services

Digital microscopy system consisting of a scanner, camera, embedded recorded software, slide loader and slide tray for analysis of hematology samples

Abrégé

A microscope for computational imaging may include an illumination source configured to illuminate a sample with a plurality of wavelengths, an image sensor, an objective lens to image the sample onto the image sensor, and a processor operatively coupled to the illumination assembly and the image sensor. The processor may be configured to acquire a first image dataset from the sample illuminated using a first set of illumination conditions at a first wavelength. The processor may also be configured to acquire a second image dataset from the sample illuminated using a second set of illumination conditions having a second number of illumination conditions at a second wavelength. The second set of illumination conditions comprises fewer illumination conditions than the first set in order to decrease acquisition time. The processor may be configured to combine the first and second image datasets into a computationally reconstructed image of the sample.

Classes IPC  ?

• H04N 9/083 - Générateurs de signaux d'image avec une seule tête de lecture dans lequel les signaux de couleur sont caractérisés par leur fréquence
• H04N 9/04 - Générateurs de signaux d'image
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/24 - Structure du bâti ou statif

Abrégé

A scanning microscope for z-stack acquisition may include, a stage to hold a sample, an illumination source to illuminate the sample, and an image capture device configured to capture multiple images of the sample within a field of view of the image capture device. The microscope may also include a lateral actuator for changing a relative lateral position between the image capture device and an imaged portion of the sample within the field of view of the image capture device for each of the images, and a focus actuator configured to adjust a focal distance between the sample and the image capture device between each of the images. The microscope may further include a processor connected to the lateral actuator and the focus actuator to move the sample laterally relative to the field of view and capture an area of the sample for each of multiple movement paths.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

A microscope system for scanning a bone marrow aspirate (BMA) sample may include a scanning apparatus for scanning the BMA sample and a processor coupled to the scanning apparatus and a memory. The microscope system may obtain, using the scanning apparatus, scan data of the BMA sample and detect cells in the BMA sample from the scan data. The microscope system may also classify the detected cells into a plurality of cell types, and store, in the memory, cell data of the classified cells. The microscope system may include a display for presenting the cell data. Various other systems and methods are provided.

Classes IPC  ?

• G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres

Abrégé

A microscope for computational microscopic layer separation may include an imaging device that includes a lens and an image sensor, an illumination system for illuminating a sample, and an actuator to adjust an axial position of a focal plane with respect to the sample. The microscope may also include a processor operatively coupled to the imaging device and the illumination system. The processor may be configured to measure, using the image sensor and the illumination system, optical aberrations of the imaging device at the axial position, and determine whether to adjust the focal plane with respect to the sample in response to the one or more optical aberrations. Various other systems and methods are also disclosed.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.

Classes IPC  ?

• G06V 20/69 - Objets microscopiques, p. ex. cellules biologiques ou pièces cellulaires
• G01B 11/06 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la longueur, la largeur ou l'épaisseur pour mesurer l'épaisseur
• G01B 11/22 - Dispositions pour la mesure caractérisées par l'utilisation de techniques optiques pour mesurer la profondeur
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G06V 10/56 - Extraction de caractéristiques d’images ou de vidéos relative à la couleur
• G06V 10/141 - Commande d’éclairage
• G06V 20/64 - Objets tridimensionnels

Abrégé

A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.

Classes IPC  ?

• G02B 21/26 - PlatinesMoyens de réglage pour celles-ci
• G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• G02B 21/00 - Microscopes

Abrégé

A microscope including an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample including artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The processor can be configured to change the imaging process in response to regions of the sample that includes artifacts or empty space. The imaging process may include a higher resolution process to output higher resolution portions of the computational image for sample regions including valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions including valid sample material.

Classes IPC  ?

• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/00 - Microscopes
• G02B 21/12 - Condensateurs donnant un éclairage sur fond clair

Abrégé

A microscope for computational imaging may include an illumination source configured to illuminate a sample with a plurality of wavelengths, an image sensor, an objective lens to image the sample onto the image sensor, and a processor operatively coupled to the illumination assembly and the image sensor. The processor may be configured to acquire a first image dataset from the sample illuminated using a first set of illumination conditions at a first wavelength. The processor may also be configured to acquire a second image dataset from the sample illuminated using a second set of illumination conditions having a second number of illumination conditions at a second wavelength. The second set of illumination conditions comprises fewer illumination conditions than the first set in order to decrease acquisition time. The processor may be configured to combine the first and second image datasets into a computationally reconstructed image of the sample.

Classes IPC  ?

• G02B 7/09 - Montures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour lentilles avec mécanisme de mise au point ou pour faire varier le grossissement adaptés pour la mise au point automatique ou pour faire varier le grossissement de façon automatique
• G02B 7/36 - Systèmes pour la génération automatique de signaux de mise au point utilisant des techniques liées à la netteté de l'image
• G02B 21/02 - Objectifs
• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur

Abrégé

Access to microscope images while a sample is scanned or images are generated or uploaded can decrease an amount of time that a user waits to view a region of interest of an image. A processor can be configured to allow a remote user to access a portion of an image at full or partial resolution while other portions of the sample are being scanned, or while one or more images are generated or uploaded at full or partial resolution. A processor stored locally with the microscope can be configured to allow a remote user to access a completed scan over the internet prior to the scan being fully uploaded over a network such as the internet to a remote server. In some embodiments, a processor may be coupled to a microscope, a user device, or a remote server.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G06T 7/11 - Découpage basé sur les zones
• G06F 16/955 - Recherche dans le Web utilisant des identifiants d’information, p. ex. des localisateurs uniformisés de ressources [uniform resource locators - URL]
• G02B 21/00 - Microscopes

Abrégé

A microscope comprising an illumination assembly, an image capture device and a processor can be configured to selectively identify regions of a sample comprising artifacts or empty space. By selectively identifying regions of the sample that have artifacts or empty space, the amount of time to generate an image of the sample and resources used to generate the image can be decreased substantially while providing high resolution for appropriate regions of the computational image. The can be processor configured to change the imaging process in response to regions of the sample that comprises artifacts or empty space. The imaging process may comprise a higher resolution process to output higher resolution portions of the computational image for sample regions comprising valid sample material, and a lower resolution process to output lower resolution portions of the computational image for sample regions comprising valid sample material.

Classes IPC  ?

• G02B 21/06 - Moyens pour éclairer un échantillon
• G06T 3/40 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement
• G06T 5/50 - Amélioration ou restauration d'image utilisant plusieurs images, p. ex. moyenne ou soustraction
• H04N 1/409 - Amélioration des contours ou des détailsSuppression du bruit ou des erreurs

Abrégé

A microscope system may comprise a plurality of microscope modules, a cassette for holding a plurality of slides, a slide loader configured to move the plurality of slides between the cassette and the plurality of microscope modules, and a processor coupled to the slide loader. The processor may be configured with instructions which, when executed, cause the slide loader to move a slide into or from a selected microscope module among the plurality of microscope modules. Various other methods, systems, and computer-readable media are also disclosed.

Classes IPC  ?

• G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
• G01N 35/04 - Détails du transporteur
• G02B 21/26 - PlatinesMoyens de réglage pour celles-ci

Abrégé

A microscope for adaptive sensing may comprise an illumination assembly, an image capture device configured to collect light from a sample illuminated by the assembly, and a processor. The processor may be configured to execute instructions which cause the microscope to capture, using the image capture device, an initial image set of the sample, identify, in response to the initial image set, an attribute of the sample, determine, in response to identifying the attribute, a three-dimensional (3D) process for sensing the sample, and generate, using the determined 3D process, an output image set comprising more than one focal plane. Various other methods, systems, and computer-readable media are also disclosed.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/24 - Structure du bâti ou statif

Abrégé

Systems and methods are disclosed for focusing a microscope using images acquired under multiple illumination conditions. In one implementation, an autofocus microscope may include an image capture device, a focus actuator, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate a sample at a first illumination condition and at a second illumination condition. The controller may acquire a first image of the sample illuminated from the first illumination angle and a second image of the sample illuminated from the second illumination angle. The controller may further determine an amount of shift between image features present in the first image of the sample and a corresponding image features present in the second image of the sample, If the amount of determined shift is non-zero, the focus actuator may change the distance between the sample and the focal plane.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 21/24 - Structure du bâti ou statif
• G02B 7/09 - Montures, moyens de réglage ou raccords étanches à la lumière pour éléments optiques pour lentilles avec mécanisme de mise au point ou pour faire varier le grossissement adaptés pour la mise au point automatique ou pour faire varier le grossissement de façon automatique
• G02B 7/36 - Systèmes pour la génération automatique de signaux de mise au point utilisant des techniques liées à la netteté de l'image
• G02B 21/02 - Objectifs
• G02B 21/06 - Moyens pour éclairer un échantillon
• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• H04N 5/225 - Caméras de télévision

Abrégé

Access to microscope images while a sample is scanned or images are generated or uploaded can decrease an amount of time that a user waits to view a region of interest of an image. A processor can be configured to allow a remote user to access a portion of an image at full or partial resolution while other portions of the sample are being scanned, or while one or more images are generated or uploaded at full or partial resolution. A processor stored locally with the microscope can be configured to allow a remote user to access a completed scan over the internet prior to the scan being fully uploaded over a network such as the internet to a remote server. In some embodiments, a processor may be coupled to a microscope, a user device, or a remote server.

Classes IPC  ?

• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• H04N 19/423 - Procédés ou dispositions pour le codage, le décodage, la compression ou la décompression de signaux vidéo numériques caractérisés par les détails de mise en œuvre ou le matériel spécialement adapté à la compression ou à la décompression vidéo, p. ex. la mise en œuvre de logiciels spécialisés caractérisés par les dispositions des mémoires
• H04W 48/18 - Sélection d'un réseau ou d'un service de télécommunications

Abrégé

Methods and systems are provided for improved imaging and analyzing of a sample with a large field-of-view at a high image resolution. A diagnostic system may comprise: a microscope comprising a low collection numerical aperture (NA); an imaging device coupled to the microscope; and a processor coupled to the imaging device. The imaging device may be configured to capture a plurality of low-resolution images of a region of a sample viewed by the microscope. The region of the sample may comprise cells. The processor may comprise instructions configured to reconstruct a high-resolution image of the region of the sample using the plurality of low-resolution images. The processor may further comprise instructions configured to analyze a spatial field of the high-resolution image to identify at least one of a cell type or a cell structure of at least one of the cells of the region of the sample.

Classes IPC  ?

• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales

Abrégé

Disclosed herein are systems and methods for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In some cases, a microscope may include an image capture device, an illumination assembly, and a processor configured to acquire a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and to reconstruct a high resolution image in response to the plurality of images. The disclosure also provides a method for generating a high resolution image of a sample comprising acquiring a plurality of images of a sample and a fiducial marker under a plurality of different illumination conditions and reconstructing the high resolution image in response to the plurality of images.

Classes IPC  ?

• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
• G02B 21/14 - Condensateurs donnant un éclairage pour une observation en contraste de phase

Abrégé

A microscope includes an illumination assembly configured to illuminate a sample under two or more different illumination conditions, at least one image capture device configured to capture image information associated with the sample at each of the two or more different illumination conditions, at least one processing device programmed to generate an image of the sample based on a combination of image information captured at each of the two or more different illumination conditions, and at least one refractive index matching material between the illumination assembly and the sample. The refractive index matching material is different from a medium between the at least one image capture device and the sample.

Classes IPC  ?

• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée

Abrégé

Systems and methods are disclosed for constructing an image of a sample using a plurality of images acquired under multiple illumination conditions. In one implementation, a microscope may include an image capture device, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate the sample at a series of different illumination conditions. The controller may further acquire from image capture device a plurality of images of the sample, wherein the plurality of images includes at least one image for each illumination condition. The controller may also determine, from the at least one image, image data of the sample for each illumination condition. The controller may further generate, from the determined image data for each illumination condition and in a non-iterative process, a reconstructed image of the sample. The reconstructed image may have a second image resolution higher than the first image resolution.

Classes IPC  ?

• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux
• G02B 27/58 - Optique pour l'apodisation ou la super-résolvanceSystèmes optiques à ouverture synthétisée
• G02B 21/14 - Condensateurs donnant un éclairage pour une observation en contraste de phase

Abrégé

Systems and methods are disclosed for focusing a microscope using images acquired under multiple illumination conditions. In one implementation, an autofocus microscope may include an image capture device, a focus actuator, an illumination assembly, and a controller. The controller may cause the illumination assembly to illuminate a sample at a first illumination condition and at a second illumination condition. The controller may acquire a first image of the sample illuminated from the first illumination angle and a second image of the sample illuminated from the second illumination angle. The controller may further determine an amount of shift between image features present in the first image of the sample and a corresponding image features present in the second image of the sample, If the amount of determined shift is non-zero, the focus actuator may change the distance between the sample and the focal plane.

Classes IPC  ?

• G02B 21/24 - Structure du bâti ou statif

Abrégé

Microscopes and methods for processing images of a sample are disclosed. In one implementation, a microscope includes an illumination assembly configured to illuminate the sample under two or more different illumination conditions. The microscope further includes at least one image capture device configured to capture image information associated with the sample and at least one controller. The at least one controller is programmed to receive, from the at least one image capture device, a plurality of images associated with the sample. At least a first portion of the plurality of images is associated with a first region of the sample, and a second portion of the plurality of images is associated with a second region of the sample. The at least one controller is further programmed to initiate a first computation process to generate a high resolution image of the first region by combining image information selected from the first portion of the plurality of images; receive, after initiating the first computation process and before completing the first computation process, a request associated with prioritizing a second computation process for generating a high resolution image of the second region; and initiate, after receiving the request, the second computation process to generate the high resolution image of the second region by combining image information selected from the second portion of the plurality of images.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G06F 19/00 - Équipement ou méthodes de traitement de données ou de calcul numérique, spécialement adaptés à des applications spécifiques (spécialement adaptés à des fonctions spécifiques G06F 17/00;systèmes ou méthodes de traitement de données spécialement adaptés à des fins administratives, commerciales, financières, de gestion, de surveillance ou de prévision G06Q;informatique médicale G16H)
• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G06T 3/40 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement