DH Technologies Development Pte. Ltd.

Singapour

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Juridiction
        International 567
        États-Unis 522
        Canada 6
Date
Nouveautés (dernières 4 semaines) 14
2025 mai (MACJ) 14
2025 avril 8
2025 mars 5
2025 février 12
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Classe IPC
H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules 462
H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques 185
H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons 161
H01J 49/26 - Spectromètres de masse ou tubes séparateurs de masse 143
H01J 49/06 - Dispositifs électronoptiques ou ionoptiques 111
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Statut
En Instance 188
Enregistré / En vigueur 907
Résultats pour  brevets
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1.

DISSOCIATION METHOD OF DNA IN MASS SPECTROMETRY

      
Numéro d'application IB2024061555
Numéro de publication 2025/109466
Statut Délivré - en vigueur
Date de dépôt 2024-11-19
Date de publication 2025-05-30
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Baba, Takashi
  • Karasawa, Kaoru
  • Ryumin, Pavel

Abrégé

A method for dissociating an oligonucleotide is disclosed. A plurality of precursor ions of one or more oligonucleotides is loaded into an ion trap. Negative radical-induced dissociation is applied to the plurality of precursor ions in the ion trap during a first time period, producing charge-reduced ions. Resonant CID is applied in the ion trap during a second time period to dissociate the charge-reduced ions. A pause without any dissociation in the ion trap is performed during a third time period to cool ions produced from the previous resonant CID or again negative radical-induced dissociation is applied in the ion trap during the third time period to again produce charge-reduced ions from the plurality of precursor ions while at a same time allowing ions produced from the previous resonant CID to be cooled. The last two steps are repeated one or more times.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

2.

SYSTEMS AND METHODS FOR LIQUID-TO-LIQUID CONTACT SAMPLING

      
Numéro d'application IB2024061695
Numéro de publication 2025/109526
Statut Délivré - en vigueur
Date de dépôt 2024-11-22
Date de publication 2025-05-30
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Kovarik, Peter
  • Covey, Thomas R.

Abrégé

A method of sampling a sample liquid disposed in a receptacle includes forming a meniscus of a transport liquid at a port of an open port interface (OPI). The sample liquid is contacted with the transport liquid, thereby transferring at least some of the contents of the sample liquid to the transport liquid.

Classes IPC  ?

  • G01N 1/38 - Dilution, dispersion ou mélange des échantillons
  • G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
  • G01N 35/08 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant un courant d'échantillons discrets circulant dans une canalisation, p. ex. analyse à injection dans un écoulement

3.

Ultra Low Noise Floated High Voltage Supply For Mass Spectrometer Ion Detector

      
Numéro d'application 18979267
Statut En instance
Date de dépôt 2024-12-12
Date de la première publication 2025-05-29
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Faur, Manuel
  • Gradin, Ernesto

Abrégé

A high-voltage power supply system for a mass spectrometer comprises a ground-referenced power supply with a first transformer having a primary winding and a secondary winding, the primary winding is electrically coupled to a first source of AC power, and a floated bias voltage power supply with a second transformer having a primary winding and a secondary winding, the primary winding of the second transformer is electrically coupled to a second source of AC power. A return electrical path of the floated bias voltage power supply is electrically coupled to the ground-referenced power supply to bias an output voltage of the ground-referenced power supply. A floating shield is around the floating bias voltage power supply, and at least one resistive element is in the return electrical path of the floated bias voltage power supply to reduce noise coupled from the floated bias voltage power supply to the ground-referenced power supply.

Classes IPC  ?

  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
  • H02M 1/14 - Dispositions de réduction des ondulations d'une entrée ou d'une sortie en courant continu

4.

CAPILLARY ELECTROPHORESIS METHODS FOR CHARACTERIZING GENOME INTEGRITY

      
Numéro d'application 18715638
Statut En instance
Date de dépôt 2022-12-06
Date de la première publication 2025-05-29
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Jones, Elliott
  • Li, Tingting
  • Luo, Jane
  • Mollah, Sahana
  • Pulido, Mario
  • Yang, Zhichang

Abrégé

Disclosed herein are methods for analyzing biological samples using capillary electrophoresis, including the characterization of genome integrity, assessment of genomic integrity and the sequencing of a nucleic acid genome, such as an RNA genome. Kits for characterizing genome integrity are also disclosed.

Classes IPC  ?

  • C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
  • C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
  • C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
  • G01N 27/447 - Systèmes utilisant l'électrophorèse

5.

MASS SPECTROMETRY AND NOISE ESTIMATION

      
Numéro d'application 18841594
Statut En instance
Date de dépôt 2023-02-24
Date de la première publication 2025-05-22
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Ivosev, Gordana

Abrégé

Mass analysis systems, computing systems, non-transitory computer-readable media, and methods analyze peaks of interest in a mass spec data signal while accounting for acquisition parameters of a mass spectrometer that affect noise present in the mass spec data signal.

Classes IPC  ?

  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
  • G06F 17/18 - Opérations mathématiques complexes pour l'évaluation de données statistiques

6.

MASS SPECTROMETER AUTOMATIC TUNING FEEDBACK

      
Numéro d'application IB2024061351
Numéro de publication 2025/104656
Statut Délivré - en vigueur
Date de dépôt 2024-11-14
Date de publication 2025-05-22
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Chelur, Anjali
  • Alvarez, Claudia
  • Ivosev, Gordana
  • Bloomfield, Nic
  • Tate, Stephen

Abrégé

Systems and methods for evaluating the operational state of a mass measuring system, including its tuning include a first mass separator in series with a second mass separator, with the second mass separator being faster than the first mass separator. Unprocessed mass data of detection of a set of ions is received from the second mass separator. A known ion is identified in the unprocessed mass data, and an actual appearance and an actual disappearance of the known ion is mapped to determine an appearance period of the known ion. The appearance period is compared with an intended appearance period for the known ion, and, based on the comparing, a match status between the appearance period and the intended appearance period is determined for the unfragmented mass.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

7.

DATA STRUCTURES FOR RAPID EXTRACTION OF SPECTRA AND CHROMATOGRAMS

      
Numéro d'application IB2024061367
Numéro de publication 2025/104671
Statut Délivré - en vigueur
Date de dépôt 2024-11-14
Date de publication 2025-05-22
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Tate, Stephen A.
  • Ivosev, Gordana
  • Bloomfield, Nic

Abrégé

Systems and methods of constructing mass spectrometry data structures for increased high-dimensional extraction. Mass spectrometry data, including intensities for one or more product ions and an offset for each of the intensities, is obtained and the intensities for the one or more product ions are recorded in a first m x n matrix with an n-dimension corresponding to a time dimension and an m-dimension corresponding to a mass-to-charge dimension. The first m x n matrix is transposed into a second m x n matrix with an n-dimension corresponding to a mass-to-charge dimension and an m- dimension corresponding to a time dimension and each of the first and second m x n matrices is stored as an index of the mass spectrometry data.

Classes IPC  ?

  • G16C 20/90 - Langages de programmationArchitectures informatiquesSystèmes de bases de donnéesStockage de données
  • G06F 16/22 - IndexationStructures de données à cet effetStructures de stockage
  • G06F 16/901 - IndexationStructures de données à cet effetStructures de stockage
  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques

8.

Natural Isotopologues Based-Mass Spectrometer Calibration

      
Numéro d'application 18722148
Statut En instance
Date de dépôt 2022-12-14
Date de la première publication 2025-05-15
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Daniels, Scott
  • Lai, Yongquan
  • Purkayastha, Subhasish

Abrégé

In one aspect, a calibration mass standard for use in mass spectrometry is disclosed, which includes a plurality of natural isotopologues of a compound, where the natural isotopologues are present in the mass standard at relative concentrations corresponding to their natural atomic abundances.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • G01N 30/62 - Détecteurs spécialement adaptés à cet effet
  • G01N 30/72 - Spectromètres de masse
  • G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes

9.

COMPOUND IDENTIFICATION USING A MASS SPECTRUM

      
Numéro d'application 18835672
Statut En instance
Date de dépôt 2023-02-02
Date de la première publication 2025-05-15
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Cox, David Michael
  • Ivosev, Gordana

Abrégé

A measured mass spectrum and intensity data provided as a function of m/z and at least one additional dimension are received. Peaks of the measured spectrum are compared to peaks of each of a plurality of library mass spectra. A set of library mass spectra is identified using a fit score. For each spectrum of the set, a group of related peaks of the measured spectrum calculated using a deconvolution algorithm is recalculated. The recalculation lowers a threshold for selection in the group if a matching peak of the library spectrum contributed to the fit score. A group of related peaks of the measured spectrum is produced for each library spectrum. For each spectrum of the set, peaks of the group are compared to peaks of the library spectrum and a purity score is calculated. At least one library spectrum of the set with the highest purity score is identified.

Classes IPC  ?

  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

10.

Open Port Interfaces

      
Numéro d'application 18333535
Statut En instance
Date de dépôt 2023-06-12
Date de la première publication 2025-05-08
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Arnold, Don W.

Abrégé

Integrated system for delivering sample to a mass spectrometer, which includes a chamber extending from a top to bottom end, an open port probe disposed in the chamber such that an open end of the probe, which is configured for receiving a sample, is positioned in proximity to top end of the chamber. The system can further include a solvent inlet port coupled to said chamber for receiving a solvent and directing said solvent to said probe, and a solvent outlet port for receiving a flow of the solvent from the open port probe and directing the received solvent out of the chamber. The system can also include an adapter for receiving a sample holder having an outlet port, the adapter is releasable and replaceable and couple with chamber to align the outlet port of sample holder with open end of probe for delivering sample to the probe.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

11.

SYSTEMS AND METHODS FOR IMPROVING ANALYSIS OF CHARGE SERIES SPECTRA

      
Numéro d'application 18837043
Statut En instance
Date de dépôt 2023-02-10
Date de la première publication 2025-05-08
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Burton, Lyle Lorrence

Abrégé

A method and system include receiving a charge series spectrum having charge series peaks, determining reconstructed mass values based on the received charge series spectrum, displaying the reconstructed mass values, receiving a selection of a displayed reconstructed mass value, and displaying a plurality of icons including a marker and a corresponding charge series peak, the marker identifying a charge of the spectrum. Another method and system include receiving a charge series spectrum having charge series peaks, determining reconstructed mass values based on the received charge series spectrum, and for each reconstructed mass value, determining a plurality of markers corresponding to charges of the charge series and having a corresponding charge series peak, and determining that the reconstructed mass value is a probable artifact when a difference between one of the markers and a local maximum of the corresponding charge series peak is greater than a threshold.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

12.

MASS SPECTROMETRY-BASED METHOD AND SYSTEM FOR ENZYME ENGINEERING

      
Numéro d'application IB2024060438
Numéro de publication 2025/093998
Statut Délivré - en vigueur
Date de dépôt 2024-10-23
Date de publication 2025-05-08
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Liu, Chang

Abrégé

Examples of this disclosure include methods and systems of enzyme engineering, including preparing a plurality of DNA samples, combining at least one of the plurality of DNA samples with a host cell, incubating the combined at least one of the plurality of DNA samples and the host cell at one of a desired first temperature and for a desired first period of time to generate a plurality of first enzymes, adding a first cell lysis reagent to the combined at least one of the plurality of DNA samples and the host cell to release the plurality of first enzymes, adding a first catalyzing substrate to the plurality of first enzymes to generate a first product and a first by-product for each first enzyme via catalysis, evaluating a first reaction yield for each first enzyme, and selecting a first enzyme from the plurality of first enzymes based on the evaluation.

Classes IPC  ?

  • G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
  • C12N 15/09 - Technologie d'ADN recombinant
  • C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques

13.

DISCRETE PEG MOLECULES AS ANALYTES FOR MS CALIBRATION AND TUNING IN POSITIVE AND NEGATIVE MODES

      
Numéro d'application 18683343
Statut En instance
Date de dépôt 2022-08-11
Date de la première publication 2025-05-01
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Purkayastha, Subhasish
  • Dey, Subhakar

Abrégé

The disclosure provides compositions, methods, and kits that find use in calibrating a mass spectrometer, and can include one or more predetermined concentration(s) of one or more calibrant molecule(s) that comprise a polyethylene glycol (PEG) compounds that have a single functional group that can be ionized by an ion source, and a solvent for dissolving the calibrant molecule(s). The calibrant molecule(s) and compositions including them can be used in either positive or negative ionization mode, and can be used for calibrating a variety of mass spectrometers (e.g., APCI, ESI) operating in a variety of acquisition modes (e.g., MRM, MS/MS, etc.).

Classes IPC  ?

  • C08L 71/02 - Oxydes des polyalkylènes
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

14.

SIMPLIFIED COMPOUND IDENTIFICATION

      
Numéro d'application 18686627
Statut En instance
Date de dépôt 2022-09-13
Date de la première publication 2025-05-01
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Cox, David
  • Tate, Stephen

Abrégé

Disclosed are systems and methods for facilitating compound identification based on analytical data obtained from an analytical instrument such as, for example, a mass spectrometer.

Classes IPC  ?

  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

15.

Method and Systems for Analyzing Ions Using Differential Mobility Spectrometry and Ion Guide Comprising Additional Auxiliary Electrodes

      
Numéro d'application 18722014
Statut En instance
Date de dépôt 2022-12-13
Date de la première publication 2025-04-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Bloomfield, Nicholas G.
  • Chernushevich, Igor
  • Le Blanc, Yves

Abrégé

Methods and systems for performing differential mobility spectrometry-mass spectrometry (DMS-MIS) are provided herein. In various aspects, methods and systems described may be effective to improve the performance of a differential mobility spectrometry device and a MS device operating in tandem relative to conventional systems for DMS-MS. In certain aspects, methods and systems in accordance with the present teachings utilize an ion guide which comprises a multipole rod set and a plurality of auxiliary electrodes to which a DC voltage is applied during transmission of ions through the ion guide so as to generate an axial electric field along a longitudinal axis of the ion guide to accelerate the ions toward the outlet end of the ion guide. This may significantly reduce a pause duration between the application of different compensation voltage values without substantially increasing the likelihood of contamination or cross-talk between groups of ions transmitted by the differential mobility spectrometry device at each compensation voltage value.

Classes IPC  ?

  • G01N 27/623 - Spectrométrie de mobilité ionique combinée à la spectrométrie de masse
  • G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]
  • H01J 49/06 - Dispositifs électronoptiques ou ionoptiques
  • H01J 49/24 - Systèmes à vide, p. ex. maintenant des pressions voulues

16.

Methods and Systems for Extracting Analytes From a Sample

      
Numéro d'application 18686223
Statut En instance
Date de dépôt 2022-08-23
Date de la première publication 2025-04-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Covey, Thomas
  • Liu, Chang

Abrégé

In various aspects, integrated specimen collection and analyte extraction devices are provided herein. For example, in accordance with various aspects of the present teachings. a device for extracting analytes from a specimen is provided, the device comprising a housing (12) defining an extraction chamber (14) for containing a known volume of a liquid specimen and having an inlet (16) for receiving the liquid specimen. A stationary phase (20) is configured to be disposed within the extraction chamber (14) in contact with the liquid sample so as to adsorb one or more analyte species thereto, wherein at least one of the stationary phase (20) and the one or more analytes adsorbed thereto within the extraction chamber (14) is removable from the extraction chamber (14) for analysis by a chemical analyzer.

Classes IPC  ?

  • G01N 1/40 - Concentration des échantillons
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

17.

AUTOMATIC DATA PROCESSING FOR MASS SPECTROMETRY

      
Numéro d'application 18688450
Statut En instance
Date de dépôt 2022-08-31
Date de la première publication 2025-04-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Liu, Chang
  • Veiga, Cristiano

Abrégé

Methods and systems for mass analysis are disclosed herein. An example system includes: a sample ejector configured to eject a plurality of samples from a plurality of wells of a well plate; a capture probe configured to capture the ejected samples and dilute and transport the captured samples; a nebulizer nozzle configured to receive and ionize the transported diluted samples to produce sample ions; a mass analysis instrument configured to filter and detect ions of interest from the sample ions; a controller configured to coordinate operations of the sample ejector, the capture probe, the nebulizer nozzle, and the mass analysis instrument; and a data processing system configured to acquire data from the mass analysis instrument and conduct an automatic data processing process.

Classes IPC  ?

  • G01N 30/72 - Spectromètres de masse
  • G01N 30/02 - Chromatographie sur colonne
  • G01N 30/86 - Analyse des signaux
  • G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

18.

TIME OF FLIGHT MASS SPECTROMETER

      
Numéro d'application IB2024060100
Numéro de publication 2025/083550
Statut Délivré - en vigueur
Date de dépôt 2024-10-15
Date de publication 2025-04-24
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Haufler, Robert
  • Booy, Aaron

Abrégé

In one aspect, a time-of-flight (TOF) mass analyzer is disclosed, which includes an inlet for receiving ions, a first ion acceleration region in which at least a portion of the received ions is accelerated to a first energy, a first field-free ion drift region positioned downstream of the first ion acceleration region for receiving the accelerated ions, a second ion acceleration region positioned downstream of the first field-free ion drift region for receiving ions exiting the first field-free ion drift region and accelerating the ions to a second energy, a second field-free ion drift region positioned downstream of the second ion acceleration region for receiving the ions exiting the second ion acceleration region, and an ion detector for receiving ions passing through the second field-free ion drift region and generating ion detection data. The ion detection data can be analyzed to generate a mass spectrum of the detected ions.

Classes IPC  ?

19.

System and Method of Driving Radio Frequency for Multipole Ion Processing Device

      
Numéro d'application 18685537
Statut En instance
Date de dépôt 2022-08-23
Date de la première publication 2025-04-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Baba, Takashi
  • Faur, Manuel
  • Gera, Tiberiu
  • Haufler, Robert
  • Loyd, William
  • Ryumin, Pavel
  • You, Congsheng

Abrégé

A system for applying RF voltages to a multipole ion processing device, configured for use in a mass spectrometer, includes a first RF generator configured to generate a first RF voltage and apply to a first pole electrode set, a second RF generator configured to generate a second RF voltage and apply to a second pole electrode set, a first amplitude adjustor configured to adjust an amplitude of the first RF voltage, a second amplitude adjustor configure to adjust an amplitude of the second RF voltage, and a phase adjustor in communication with the first RF generator and the second RF generator to adjust phase output of at least one of the first RF generator and the second RF generator so as to adjust a phase differential between the first RF voltage and the second RF voltage to be within a desired range.

Classes IPC  ?

  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

20.

AUTOMATIC DATA PROCESSING FOR MULTIPLY CHARGED ANALYTES IN MASS SPECTROMETRY

      
Numéro d'application 18688392
Statut En instance
Date de dépôt 2022-09-02
Date de la première publication 2025-04-17
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Liu, Chang
  • Covey, Thomas R.

Abrégé

Methods and systems for automatically analyzing a collection of samples, the method including ionizing a plurality of samples, capturing a plurality of raw mass spectra for the ionized plurality of samples, correlating captured respective subsets of the raw mass spectra to each sample of the plurality of samples, and for each sample of the plurality of samples, generating a reconstructed mass spectrum based on the respective subset of the raw mass spectra of the sample. Methods and systems also include correlating the captured respective subsets of the raw mass spectra to each sample by generating a chronogram, and correlating a timeline of a sampling of the sample with the chronogram to correlate the captured respective subsets of the raw mass spectra to each sample. Methods and systems also include analyzing the generated reconstructed mass spectrum for each sample of the plurality of samples.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

21.

Laser Induced Fragmentation for MRM Analysis

      
Numéro d'application 18696002
Statut En instance
Date de dépôt 2022-09-26
Date de la première publication 2025-04-17
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Guna, Mircea
  • Le Blanc, Yves

Abrégé

In one aspect, a method for fragmenting ions in a mass spectrometer is disclosed, which includes introducing a plurality of precursor ions into a collision cell of a mass spectrometer, generating a potential barrier in the collision cell to cause at least a portion of ions in the collision cell to be trapped within a region in proximity of said potential barrier, and applying ultraviolet (UV) radiation to said trapped ions so as to cause fragmentation of at least a portion of any of said precursor ions and fragment ions thereof to generate a plurality of product ions such that a space charge generated in said region in proximity of said potential barrier due to accumulation of ions will impart sufficient kinetic energy to at least a portion of the product ions so as to overcome said potential barrier, thereby exiting said region.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

22.

Preventing Errors in Processing and Interpreting Mass Spectrometry Results

      
Numéro d'application 18420683
Statut En instance
Date de dépôt 2022-07-05
Date de la première publication 2025-04-17
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Cox, David Michael
  • Burton, Lyle Lorrence

Abrégé

An analytical instrument produces intensity versus time measurements or intensity versus m/z measurements for each acquisition of n acquisitions using m instrument parameter values for each acquisition of n acquisitions, wherein n is a number greater than or equal to two and m is a number equal to or greater than one. For each acquisition of the n acquisitions, the instrument stores a data file that includes m one or more instrument parameter values applied to the instrument, producing n data files. A first data file of the n data files for a first acquisition is retrieved. A next data file of the n data files of a next acquisition is retrieved. The m corresponding parameter values of the first data file and the next data file are compared. If any corresponding parameter values differ between the first data file and the next data file, a notification of an instrument parameter difference corresponding to a name of the next data file is displayed.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • G01N 30/86 - Analyse des signaux

23.

METHODS AND SYSTEMS FOR PERFORMING DATA INDEPENDENT ACQUISTION MASS SPECTROMETRY

      
Numéro d'application IB2024059022
Numéro de publication 2025/062288
Statut Délivré - en vigueur
Date de dépôt 2024-09-17
Date de publication 2025-03-27
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Alvarez, Claudia
  • Bloomfield, Nicholas G.
  • Chelur, Anjali
  • Ivosev, Gordana
  • Tate, Stephen

Abrégé

In one aspect, a method of operating an analytical device for measuring at least one analyte within a sample is disclosed, which includes utilizing a digital data processor to receive a sample acquisition rate for introduction of the sample into the analytical device, and to compute one or more optimal operating parameters of the analytical device based on the sample acquisition rate by optimizing a figure-of-merit associated with measurement of the analyte, where the operating parameters include a temporal duration of a measurement cycle and/or selectivity associated with the measurement. The analytical device can be operated at the optimal operating parameters while receiving the sample at the sample acquisition rate to generate sample measurement data corresponding to the analyte. The sample measurement data can be processed to derive information about the analyte.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

24.

Electron Emitter for an Ion Reaction Device of a Mass Spectrometer and Methods of Operating the Same

      
Numéro d'application 18832984
Statut En instance
Date de dépôt 2023-01-24
Date de la première publication 2025-03-13
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Cherian, Sebin
  • Loyd, William
  • Ryumin, Pavel

Abrégé

Methods and systems for controlling a filament of an electron emitter associated with an ion reaction cell in accordance with various aspects of the present teachings may account for inter-filament and inter-instrument variability and can provide improved reproducibility in EAD experiments and ease of use. In some aspects, a method of operating an ion reaction device of a mass spectrometer system is provided. The method comprises applying a calibration drive voltage to a filament of an electron emitter associated with an ion reaction cell and determining a value representative of the calibration electron emission current generated by the filament while having the calibration drive voltage applied thereto. A calibration saturation voltage can be determined by iteratively increasing the calibration drive voltage applied to the filament and determining the value of the calibration electron emission current at each corresponding calibration drive voltage until the filament reaches a saturation condition.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/08 - Sources d'électrons, p. ex. pour produire des photo-électrons, des électrons secondaires ou des électrons d'Auger

25.

METHODS AND SYSTEMS FOR AUTOMATED IDENTIFICATION OF PROTEIN NON-COVALENT BINDING

      
Numéro d'application IB2024058718
Numéro de publication 2025/052328
Statut Délivré - en vigueur
Date de dépôt 2024-09-06
Date de publication 2025-03-13
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Le, Hieu Cuong
  • Liu, Chang

Abrégé

Methods and systems for analyzing a sample that includes a protein and a binding ligand, the method including receiving the sample at an ionization device via non-contact sampling, the first sample being in a non-denaturing carrier solvent, ionizing the first sample, generating a deconvoluted mass spectrum for the ionized first sample, and detecting binding between the protein and the binding ligand in the first sample based at least in part on the deconvoluted mass spectrum. The non-contact sampling is performed via a non-contact sample ejector. Methods and systems for analyzing a sample that includes a protein includes receiving the sample via non-contact sampling, the sample being in one of a plurality of non-denaturing carrier solvents, and for non-denaturing carrier solvent, ionizing the sample, generating a deconvoluted mass spectrum for the ionized sample, and detecting protein binding in the first sample based at least in part on the deconvoluted mass spectrum.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

26.

QUADRUPOLE MASS SPECTROMETER DESIGN

      
Numéro d'application IB2024058662
Numéro de publication 2025/052300
Statut Délivré - en vigueur
Date de dépôt 2024-09-05
Date de publication 2025-03-13
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Faur, Manuel
  • Guna, Mircea
  • Bouma, Christopher
  • Marinkovic, Slobodan
  • Xian, Liang

Abrégé

In one aspect, a heat transfer structure for use in a mass spectrometer can include a collar for surrounding a plurality of rods arranged in a multipole configuration, at least one ceramic pad positioned to be in thermal contact with at least one of the rods, and at least one thermally conductive plate positioned to provide a heat transfer path between the at least one ceramic pad and the collar. The heat transfer structure can further include a bracket mounted on a bracket mounting portion of the collar for transferring heat from the collar to a rail.

Classes IPC  ?

  • H01J 49/06 - Dispositifs électronoptiques ou ionoptiques
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

27.

MASS ANALYSIS

      
Numéro d'application 18714055
Statut En instance
Date de dépôt 2022-12-06
Date de la première publication 2025-03-06
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Tate, Stephen

Abrégé

Systems, apparatus, and computer-readable storage media are disclosed for analyzing samples of a well plate. Systems may include a well plate, a mass spectrometer, and a computing device. The well plate may include rows of wells. The mass spectrometer may sequentially capture a sample from each well of the rows of wells and generate spectral data that includes mass spectrum data for each captured sample. The computing device may receive the spectral data generated by the mass spectrometer, detect rows of spectral data in the spectral data, wherein each row of spectral data corresponds to a row of wells in the well plate; and generate a spectral data matrix from the detected rows of spectral data such that each row of wells comprises a corresponding row of spectral data in the spectral data matrix.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

28.

SYSTEMS AND METHODS FOR INTRODUCING SOLVENTS TO A SAMPLING INTERFACE

      
Numéro d'application IB2024058141
Numéro de publication 2025/041059
Statut Délivré - en vigueur
Date de dépôt 2024-08-21
Date de publication 2025-02-27
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Ang, Wan Ee

Abrégé

A solvent delivery system for an open port interface (OPI) includes a first diverter which includes a wash solvent inlet, a carrier solvent inlet, and a first diverter outlet. A wash solvent pump is fluidically coupled to the wash solvent inlet. A carrier solvent pump is fluidically coupled to the carrier solvent inlet. A second diverter includes a second diverter inlet fluidically coupled to the first diverter outlet. An OPI port is configured to be coupled to an OPI. A waste outlet is configured to be coupled to a waste container.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

29.

METHODS AND SYSTEMS FOR GENERATING A CONTROLLABLE AXIAL PSEUDOPOTENTIAL BARRIER IN MULTIPOLE ROD SETS OF MASS SPECTROMETERS

      
Numéro d'application IB2024058242
Numéro de publication 2025/041105
Statut Délivré - en vigueur
Date de dépôt 2024-08-23
Date de publication 2025-02-27
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Ryumin, Pavel
  • Baba, Takashi
  • Gera, Tiberiu

Abrégé

The present teachings are generally related to generating a pseudo potential barrier via an axial RF field. As discussed herein in more detail, such a pseudo potential barrier can be employed in a variety of different applications. By way of example, such a pseudo potential barrier can be employed for trapping ions within a rod set comprising a plurality of rods arranged in a multipole configuration. In other applications, an adjustment of the height of the pseudo potential barrier established in a rod set together with application of a DC potential between the rod set and an external electrode can be utilized to cause mass selective extraction of ions trapped within the rod set. In yet other applications, such a pseudo potential barrier can be employed in multiplexing approaches for performing mass spectrometry.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

30.

METHODS AND SYSTEMS FOR PERFORMING TANDEM MS/MS/MS MASS SPECTROMETRY

      
Numéro d'application IB2024058244
Numéro de publication 2025/041106
Statut Délivré - en vigueur
Date de dépôt 2024-08-23
Date de publication 2025-02-27
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Ryumin, Pavel
  • Baba, Takashi
  • Gera, Tiberiu

Abrégé

The present teachings are generally related to a method of performing mass spectrometry, which includes dissociating a plurality of precursor ions to generate a first set of product ions, wherein ions with approximately same m/z are associated in a group, and wherein said first set of product ions contains at least two groups of ions with distinct m/z's. The method further includes introducing the first set of product ions into an ion trap; transferring different groups of the first set of product ions during different time intervals from the ion trap to an ion dissociation device so as to cause dissociation of at least a portion of the first set of product ions to generate a second set of product ions, and acquiring a mass spectrum of the second set of product ions.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

31.

Method to Operate a Mass Spectrometer to Counteract Space Charge Effects

      
Numéro d'application 18718871
Statut En instance
Date de dépôt 2022-12-13
Date de la première publication 2025-02-27
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Guna, Mircea
  • Loyd, William

Abrégé

A method of performing mass spectrometry is disclosed. which comprises introducing a plurality of ions into an ion guide of a mass spectrometer via an inlet orifice thereof. where the ion guide includes a plurality of rods arranged in a multipole configuration and spaced from one another to provide a passageway for transit of the ions therethrough. applying RF voltages to the rods so as to generate an electromagnetic field within the passageway for providing radial confinement of the ions passing through the passageway, identifying a space charge effect, which can adversely affect operation of the mass spectrometer, based on detection of a variation of an intensity of an ion detection signal associated with at least one ion population transmitted through said ion guide and having an m/z ratio greater than a threshold, and in response to said identification of the adverse space charge effect. adjusting at least one of frequency and amplitude of the RF voltages to counteract said space charge effect.

Classes IPC  ?

  • H01J 49/06 - Dispositifs électronoptiques ou ionoptiques

32.

Systems and Methods for Detecting Leaks from Liquid Flow into an Ion Source of a Mass Spectrometry System

      
Numéro d'application 18718916
Statut En instance
Date de dépôt 2022-12-13
Date de la première publication 2025-02-27
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Patel, Amit
  • Stella, Aaron

Abrégé

Leak detection systems and methods in accordance with various aspects of the present teachings can, in various embodiments, sequester fluid leaking from the interface between a sample source and the inlet of the ion source, alert an operator as to a leak condition, and/or automatically terminate the experiment. In various aspects, a liquid leak detection system is accordance with the present teachings comprises a collection basin configured to couple to a proximal end of a conduit in fluid communication with a discharge end of an ion source of a mass spectrometer such that the proximal end of the conduit extends through the internal volume of the basin. The system may also comprise a drainage tube having an inlet end opening into an internal volume of the collection basin and configured to drain liquid therefrom, a sensor disposed within the basin or the drainage tube and configured to generate a signal indicative of liquid therewithin, and a processor that is configured to cause a user to be alerted and/or cause an experiment to be terminated upon receiving from the sensor a signal indicative of a leak.

Classes IPC  ?

  • G01M 3/20 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des révélateurs particuliers, p. ex. teinture, produits fluorescents, produits radioactifs

33.

SYSTEMS AND METHODS FOR ERROR CORRECTION IN FAST SAMPLE READERS

      
Numéro d'application 18725973
Statut En instance
Date de dépôt 2022-12-22
Date de la première publication 2025-02-27
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Liu, Chang
  • Cox, David M.

Abrégé

A method and system for detecting a signal measurement error, the method including providing a well plate including error correction wells and sample wells, each sample well including a single sample, and each error correction well including a mixture of samples from two or more sample wells. The method includes receiving an aliquot from the wells at a sample receiver, measuring a signal for the received aliquot, calculating an expected signal for each of the error correction wells, comparing the measured signal to the calculated expected signal for each error correction well, and determining whether an error exists in the signal of at least one sample well. When the error exists, the method correlates the error to one or more sample wells.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

34.

ELECTRON DETACHMENT METHOD AND DEVICE FOR OLIGONUCLEOTIDE ANALYSIS IN MASS SPECTROMETRY

      
Numéro d'application IB2024058146
Numéro de publication 2025/041062
Statut Délivré - en vigueur
Date de dépôt 2024-08-21
Date de publication 2025-02-27
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Baba, Takashi
  • Ryumin, Pavel
  • Karasawa, Kaoru

Abrégé

Mass spectrometry systems and methods are disclosed. In some embodiments, the mass spectrometry system comprises an ion trap configured to receive a plurality of precursor ions and to load the plurality of precursor ions in a trap region; an electron gun configure to perform an irradiation operation by applying an electron beam to the trap region to produce fragmented ions; an RF gate configured to perform an extraction operation by extracting, from the trap region, a high m/z subset of the fragmented ions with m/z ratios greater than a specific value; and a mass spectrometer configured to perform mass spectrometry analysis on a subset of the fragmented ions remaining in the trap region, wherein an irradiation-extraction operation, including performing the irradiation operation and the extraction operation, is repeated at least twice before performing the mass spectrometry analysis on the subset of the fragmented ions remaining in the trap region.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

35.

ION PROCESSING DEVICE UTILIZING DUAL RF CIRCUIT

      
Numéro d'application IB2024058239
Numéro de publication 2025/041104
Statut Délivré - en vigueur
Date de dépôt 2024-08-23
Date de publication 2025-02-27
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Ryumin, Pavel
  • Baba, Takashi
  • Gera, Tiberiu

Abrégé

The present teachings are generally related to generating a pseudo potential barrier via an axial RF field. A first RF voltage is applied to a first pair of rods arranged in a multipole configuration, a second RF voltage is applied to a second pair of rods, and a difference between amplitudes and/or phases of said first RF voltage and said second RF voltage is adjusted. As discussed herein in more detail, such a pseudo potential barrier can be employed in a variety of different applications. By way of example, such a pseudo potential barrier can be employed for trapping ions within a rod set comprising a plurality of rods arranged in a multipole configuration. In other applications, an adjustment of the height of the pseudo potential barrier established in a rod set together with application of a DC potential between the rod set and an external electrode can be utilized to cause mass selective extraction of ions trapped within the rod set. In yet other applications, such a pseudo potential barrier can be employed in multiplexing approaches for performing mass spectrometry.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

36.

CAPILLARY ELECTROPHORESIS OF ENCAPSULATED RNA

      
Numéro d'application 18721329
Statut En instance
Date de dépôt 2022-12-22
Date de la première publication 2025-02-13
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Gutierrez, Mervin

Abrégé

The presently claimed and described technology provides methods for analyzing an encapsulated biomolecule by loading the encapsulated biomolecule on a capillary electrophoresis (CE) capillary, wherein the CE capillary is filled with a buffer comprising a polymer matrix; applying a voltage to the CE capillary to release the biomolecule from the encapsulating material; and detecting the biomolecule released from the encapsulating material. Kits for analyzing an encapsulated biomolecule are also disclosed.

Classes IPC  ?

  • G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
  • C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]

37.

CONDITIONING SOLUTION FOR A CAPILLARY

      
Numéro d'application IB2024057217
Numéro de publication 2025/027462
Statut Délivré - en vigueur
Date de dépôt 2024-07-25
Date de publication 2025-02-06
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Gutierrez, Mervin
  • Lou, Anna

Abrégé

The presently claimed and described technology is directed to electrophoretic methods for conditioning a capillary using a conditioning buffer including a surface active polymer and a separation reagent including a separation polymer.

Classes IPC  ?

38.

METHODS AND SYSTEMS FOR OPERATING AN OPEN PORT INTERFACE

      
Numéro d'application IB2024057319
Numéro de publication 2025/027500
Statut Délivré - en vigueur
Date de dépôt 2024-07-29
Date de publication 2025-02-06
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Kovarik, Peter
  • Covey, Thomas R.

Abrégé

Methods and systems for operating an OPI of a sample analysis system, the OPI having a transport liquid conduit and a sample removal conduit and being configured to flow a transport liquid therethrough to a capture region, the method including introducing the OPI at a liquid sample in a sample reservoir while supplying the transport liquid at a first flow rate to the capture region, aspirating a first amount of the liquid sample through the removal conduit via the transport liquid flowing at the first flow rate, switching a flow rate of the transport liquid flowing through the OPI to a second flow rate when a first condition is met, the second flow rate being different from the first flow rate, and aspirating a second amount of the liquid sample through the removal conduit via the transport liquid flowing at the second flow rate. Fast flow rate switching is enabled by a transport liquid flow control apparatus comprising a selectable valve having a pair of valve outlets coupled to different flow paths having different flow resistances.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

39.

REDUCTION OF UNUSED PRECURSORS IN ELECTRON ACTIVATED DISSOCIATION (EAD)

      
Numéro d'application IB2024057372
Numéro de publication 2025/027528
Statut Délivré - en vigueur
Date de dépôt 2024-07-30
Date de publication 2025-02-06
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Baba, Takashi

Abrégé

In one aspect, a method of performing mass spectrometry is disclosed, which comprises introducing a plurality of precursor ions into an ion dissociation device, dissociating at least a portion of the precursor ions into a first plurality of product ions having m/z ratios less than an m/z ratio of the precursor ions, discarding at least a portion of any precursor ions remaining subsequent to said dissociation step within said ion dissociation device, and subsequently, allowing at least a portion of said first plurality of product ions to exit from the ion dissociation device through an outlet of the ion dissociation device.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

40.

METHOD FOR IN-CAPILLARY DISSOCIATION AND ANALYSIS OF MASS SPECTRAL DATA

      
Numéro d'application IB2024057043
Numéro de publication 2025/022284
Statut Délivré - en vigueur
Date de dépôt 2024-07-19
Date de publication 2025-01-30
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Boloborodov, Stanislav
  • Ryumin, Pavel

Abrégé

Methods and non-transitory computer readable storage media for loading a reactive agent onto a fluidic device, loading a sample comprising the at least one analyte onto the fluidic device; applying a voltage to the fluidic device, wherein when the voltage is applied the reactive agent remains confined to a region in the separation channel and the at least one analyte is separated from the sample and migrates towards the fluid outlet; generating a first data set and a second data set; converting the second data set by removing a baseline; and correlating the first data set and the converted second data set.

Classes IPC  ?

  • G01N 27/447 - Systèmes utilisant l'électrophorèse
  • G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes

41.

Low Noise Bipolar High Voltage Regulator

      
Numéro d'application 18792786
Statut En instance
Date de dépôt 2024-08-02
Date de la première publication 2025-01-30
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Faur, Manuel
  • Gradin, Ernesto

Abrégé

In one aspect, a voltage regulator is disclosed, which comprises a first voltage regulator unit configured for regulating a voltage generated by a positive high voltage source, a second voltage regulator unit configured for regulating a voltage generated by a negative high voltage source, a polarity switch for connecting said first and second voltage regulator units to said positive and negative high voltage sources, respectively, and an output voltage port for receiving a regulated positive and negative high voltage from said first and said second voltage regulator units, respectively.

Classes IPC  ?

  • G05F 1/595 - Dispositifs à semi-conducteurs connectés en série
  • G05F 1/575 - Régulation de la tension ou de l'intensité là où la variable effectivement régulée par le dispositif de réglage final est du type continu utilisant des dispositifs à semi-conducteurs en série avec la charge comme dispositifs de réglage final caractérisé par le circuit de rétroaction

42.

ELECTROSPRAY EMITTER MODULE FOR CAPILLARY ELECTROPHORESIS DEVICE

      
Numéro d'application IB2024057038
Numéro de publication 2025/022282
Statut Délivré - en vigueur
Date de dépôt 2024-07-19
Date de publication 2025-01-30
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Peterson, Brian D.

Abrégé

A capillary emitter includes a coupling sleeve, a separation capillary inside the coupling sleeve, the separation capillary extending along a longitudinal axis of the coupling sleeve, a tip at an end of the coupling sleeve, the tip comprising an orifice and having an internal base, a first hollow internal cavity defined on one side thereof by the internal base in the coupling sleeve, the first hollow internal cavity comprising the separation capillary, and a fluid pathway within the first hollow internal cavity, the fluid pathway surrounding the separation capillary, wherein, at the internal base of the tip, the separation capillary and the fluid pathway are fluidly connected within the first hollow internal cavity.

Classes IPC  ?

43.

Integrated Sample Processing System with Multiple Detection Capability

      
Numéro d'application 18630611
Statut En instance
Date de dépôt 2024-04-09
Date de la première publication 2025-01-23
Propriétaire
  • BECKMAN COULTER, INC. (USA)
  • DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Hudson, Aaron
  • Mizutani, Takayuki
  • Purkayastha, Subhasish
  • Roscoe, Thomas W.

Abrégé

An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.

Classes IPC  ?

  • G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
  • G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails

44.

Electron-Based Fragmentation Method

      
Numéro d'application 18569781
Statut En instance
Date de dépôt 2022-06-24
Date de la première publication 2025-01-23
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Campbell, John Lawrence
  • Loyd, Bill
  • Ryumin, Pavel

Abrégé

The present disclosure provides methods and systems for performing mass spectrometry in which at least two batches of precursor ions generated via ionization of at least two different portions of a sample are exposed to electron beams at different energies to cause fragmentation of at least a portion of the precursor ions. In some embodiments, the electron energies can be selected such at one of the electron energies, EIEIO fragmentation can occur while at the other electron energy, EIEO fragmentation channel is not available. The mass spectra corresponding to the two energies can then be utilized to generate a resultant mass spectrum in which mass peaks corresponding to ion fragments generated by EIEIO dissociation are more readily identifiable.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

45.

HIGH THROUGHPUT MASS SPECTRAL DATA GENERATION

      
Numéro d'application 18714355
Statut En instance
Date de dépôt 2022-11-30
Date de la première publication 2025-01-16
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Tate, Stephen A.
  • Lock, Christopher

Abrégé

Methods and systems for mass spectrometry are disclosed. In one example, a method comprises: receiving, by a mass spectrometer via a sampling system operably connected thereto, at least one sample containing at least one known compound; modulat-ing at least one instrument parameter of the mass spectrometer through a plurality of instrument parameter values; analyzing the at least one sample while applying each of the plurality of instrument parameter values; acquiring a plurality of mass spectral (MS) datasets each corresponding to one of the applied plurality of instrument parameter values; encoding each of the plurality of MS datasets to generate a corresponding plurality of MS results each corresponding to one of the applied instrument parameter values; and compiling and storing the MS datasets and MS results in a spectral library in association with the applied instrument parameter values.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

46.

VOLUMETRIC MEASUREMENT OF MICRO DROPLETS

      
Numéro d'application 18774553
Statut En instance
Date de dépôt 2024-07-16
Date de la première publication 2025-01-16
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Covey, Thomas R.
  • Liu, Chang

Abrégé

Improvements in acoustically dispensed samples that are injected into an open port probe (OPP) are described. Apparatus and method are described that calibrate the volume dispensing determination and mechanisms in the acoustic dispenser to produce accurate and precise volumetric delivery.

Classes IPC  ?

  • B05B 12/00 - Aménagements de commande de la distributionAménagements de réglage de l’aire de pulvérisation
  • B05B 12/08 - Aménagements de commande de la distributionAménagements de réglage de l’aire de pulvérisation sensibles à l'état du liquide ou d'un autre matériau fluide expulsé, du milieu ambiant ou de la cible
  • B05B 17/06 - Appareils de pulvérisation ou d'atomisation de liquides ou d'autres matériaux fluides, non couverts par les autres groupes de la présente sous-classe opérant suivant des procédés particuliers utilisant des vibrations ultrasonores
  • G01F 22/00 - Procédés ou appareils pour la mesure du volume des fluides ou des matériaux solides fluents, non prévus ailleurs
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/16 - Sources d'ionsCanons à ions utilisant une ionisation de surface, p. ex. émission thermo-ionique ou photo-électrique

47.

Method for Noise Reduction and Ion Rate Estimation Using an Analog Detection System

      
Numéro d'application 18711346
Statut En instance
Date de dépôt 2022-11-21
Date de la première publication 2025-01-09
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Bloomfield, Nic G.

Abrégé

Ion intensities measured by an ADC detector subsystem are filtered using equivalent TDC event realizations. In one embodiment, an intensity measurement is received for at least one ion made by an ADC detector subsystem for each of m extractions of an ion beam, producing m intensities for the ion. Equivalent TDC event realizations are received for the ion for each intensity of the m intensities, producing m equivalent TDC event realizations. A filtered intensity for the ion is calculated that is a combination of the m intensities and the m event realizations. In another embodiment, for the ion, an equivalent TDC event realization is accumulated for ion events up to a threshold count of event realizations, N, and the ADC intensities are accumulated for all remaining ion events. A filtered intensity for the ion is calculated that is a combination of the equivalent TDC event realization and the ADC intensities.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails

48.

IMPROVED SIGNAL TO NOISE RATIO AT THE LLOQ THROUGH THE REDUCTION OF CHEMICAL NOISE

      
Numéro d'application IB2024056521
Numéro de publication 2025/008775
Statut Délivré - en vigueur
Date de dépôt 2024-07-03
Date de publication 2025-01-09
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Collings, Bruce

Abrégé

Various embodiments relate to the reduction of chemical noise at or near the mass of an analyte of interest prior to selection by a mass filter. The use of a narrow bandpass in the ion optics removes chemical noise that can repopulate ions at or near the mass of an analyte of interest by removing other chemical noise ions that can fragment into the same or similar mass as the mass of an analyte of interest through collision induced dissociation.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

49.

ANALYSIS OF CRISPR/CAS9 SYSTEM ASSOCIATED MOLECULES USING CAPILLARY ZONE ELECTROPHORESIS

      
Numéro d'application IB2024056135
Numéro de publication 2025/003864
Statut Délivré - en vigueur
Date de dépôt 2024-06-24
Date de publication 2025-01-02
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Li, Tingting

Abrégé

The disclosed technology provides capillary electrophoresis methods and kits for the separation of multiple components in one or two runs with high resolution.

Classes IPC  ?

50.

SYSTEMS AND METHODS FOR RAPID ACTIVATION OF THERMAL-CID VIA GAS CONTROL

      
Numéro d'application IB2024056220
Numéro de publication 2025/003913
Statut Délivré - en vigueur
Date de dépôt 2024-06-26
Date de publication 2025-01-02
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Leblanc, Yves J.C.

Abrégé

A method for mass spectrometry comprises ionizing an analyte in an ionizer to generate a plurality of precursor ions; applying temporally modulated energy to the plurality of precursor ions within the ionizer to generate a plurality of fragments of the plurality of precursor ions; and introducing a subset of ions generated in the ionizer into a downstream chamber of a mass spectrometer. In some embodiments, applying the energy may include flowing a gas toward the precursor ions. In various embodiments, the gas may include a heating gas or a cooling gas.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

51.

METHODS AND COMPOSITIONS FOR ELECTOPHORETIC SEPARATIONS

      
Numéro d'application 18742865
Statut En instance
Date de dépôt 2024-06-13
Date de la première publication 2024-12-26
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Cruzado-Park, Ingrid D.

Abrégé

Disclosed and claims are a method for analyzing at least one analyte, the method including introducing a composition into a separation channel, wherein the composition includes at least one pH gradient compound, an amine buffer, and at least one analyte of interest; applying an electric field across the separation channel to create a pH gradient using the at least one pH gradient compound and separate the composition via isoelectric focusing, generating at least one focused analyte peak; mobilizing the at least one focused analyte peak; and wherein the amine buffer is configured to modify the pH gradient.

Classes IPC  ?

52.

SYSTEM AND METHOD FOR SAMPLE SEPARATION DIRECTED AT MASS SPECTROMETRY INDENTIFICATION ON A MICROFLUIDIC CHIP

      
Numéro d'application IB2024056048
Numéro de publication 2024/261697
Statut Délivré - en vigueur
Date de dépôt 2024-06-20
Date de publication 2024-12-26
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Bousse, Luc
  • Beloborodov, Stanislav
  • Mack, Scott
  • Schneider, Bradley

Abrégé

Described and claimed herein are systems and methods that provide streamlined coupling of CE (e.g., CE-SDS) separation with MS analysis (e.g., such as CE(SDS)-AEX-MS).

Classes IPC  ?

  • G01N 27/447 - Systèmes utilisant l'électrophorèse
  • G01N 30/96 - Recherche ou analyse de matériaux par séparation en constituants utilisant l'adsorption, l'absorption ou des phénomènes similaires ou utilisant l'échange d'ions, p. ex. la chromatographie en utilisant l'échange d'ions
  • G01N 30/60 - Préparation de la colonne

53.

METHODS FOR ENHANCING COMPLETE DATA EXTRACTION OF DIA DATA

      
Numéro d'application 18698672
Statut En instance
Date de dépôt 2022-10-05
Date de la première publication 2024-12-26
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Tate, Stephan A.

Abrégé

The n spectra of a DIA method are compared to a library of product ion spectra to identify an initial i compounds corresponding to l spectra. A reinforcement learning algorithm (RLA) is performed. (a) An agent of the RLA performs an action At that includes searching one or more compound databases for compounds related to the i compounds, producing j related compounds, and applying one or more deep learning prediction algorithms to predict k spectra for the i+j compounds. (b) An environment of the RLA compares the k spectra to the n spectra, producing a state, St, in which i+j compounds produce m matching compounds and a reward, Rt, for the agent if m>i. (c) If the Rt is produced, the i compounds are set to the m compounds and the l spectra are set to the k spectra, and steps (a)-(c) are repeated.

Classes IPC  ?

  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
  • G16C 20/40 - Recherche de structures chimiques ou de données physicochimiques
  • G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie

54.

ULTRA HIGH THROUGHPUT SCREENING COMBINED WITH DEFINITIVE TESTING IN A SINGLE SAMPLE PREPARATION STEP

      
Numéro d'application 18704242
Statut En instance
Date de dépôt 2022-10-26
Date de la première publication 2024-12-19
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Stella, Aaron
  • Weinstock, Michal
  • Lai, Yongquan
  • Purkayastha, Subhasish
  • Daniels, Scott

Abrégé

The presently claimed and described technology provides a sample processing system comprising at least one sample introduction device, wherein the at least one sample introduction device is configured to receive a sample; a mass analyzer coupled to the sample introduction device; a control system configured to at least control the at least one sample introduction device and/or the mass analyzer, wherein the mass analyzer is configured to perform a first mass analysis on the sample, wherein the first mass analysis is mass screening for an analyte of interest in the sample, and wherein if the analyte of interest is detected in the sample, the mass analyzer is configured to perform a second mass analysis, wherein the second mass analysis is a quantitative analysis, comprising: ionizing the sample; monitoring, by mass spectrometry, at least one product ion transition for the at least one analyte and at least one isotopic ion transition for the at least one analyte; determining intensity and/or abundance of the at least one product ion transition and/or the at least one isotopic ion transition; and quantifying the at least one analyte present in the sample using the intensity and/or abundance of the at least one product ion transition and/or isotopic ion transition.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

55.

METHODS AND SYSTEMS FOR ASSESSING A QUALITY OF MASS ANALYSIS DATA GENERATED BY A MASS SPECTROMETER

      
Numéro d'application 18688485
Statut En instance
Date de dépôt 2022-09-02
Date de la première publication 2024-12-19
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Liu, Chang
  • Ivosev, Gordana
  • Quinn, Alandra

Abrégé

Methods and systems for assessing a quality of mass analysis data generated by a mass analysis device, including collecting mass spectrometry data for a given compound, deriving a measured isotope profile based on the collected mass spectrometry data, determining a predicted isotope profile, determining a first quality score for the mass analysis data, the first quality score being based on a relationship between an intensity of the main peak and intensities of the one or more isotope peaks, determining a second quality score for the mass analysis data, the second quality score being based on a signal-to-noise ratio of the mass analysis data, determining an overall quality score as a combination of the first quality score and the second quality score, and assessing a quality of a compound library based on the determined overall quality score.

Classes IPC  ?

56.

FRAGMENT TYPE DRIVEN SPECTRAL PEAK

      
Numéro d'application IB2024055837
Numéro de publication 2024/257037
Statut Délivré - en vigueur
Date de dépôt 2024-06-14
Date de publication 2024-12-19
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Duchoslav, Eva

Abrégé

A method for annotating product ions of a spectrum is disclosed. A product ion mass spectrum is received. A parameter that indicates the mass spectrum was produced using a radical-induced dissociation method is received. At least one charge state mass-to-charge ratio (m/z) adjustment based on the parameter is performed for at least one product ion peak of the mass spectrum and the adjustment is compared to one or more other product ion peaks of the mass spectrum. The at least one product ion peak is annotated based on the comparison. The charge state adjustment includes the loss of an electron or the loss or gain of a hydrogen atom. The radical-induced dissociation method includes electron-based dissociation (ExD), ultraviolet photodissociation (UVPD), or infrared photodissociation (IRMPD).

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

57.

CAPILLARY ELECTROPHORESIS PURITY ANALYSIS OF COMPLEMENTARY STRAND NUCLEIC ACID MOLECULES

      
Numéro d'application 18714761
Statut En instance
Date de dépôt 2022-12-16
Date de la première publication 2024-12-19
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Li, Tingting
  • Yowanto, Handy
  • Jones, Elliott
  • Mollah, Sahana

Abrégé

The presently described and claimed disclosure relates to method for characterizing nucleic acid purity comprising denaturing a nucleic acid sample, loading the nucleic acid sample onto a capillary electrophoresis (CE) capillary, wherein the CE capillary is filled with a buffer comprising a polymer matrix, applying a separation voltage to the CE capillary, wherein during the separation of the nucleic acids, the temperature of the CE capillary is increased, and detecting nucleic acids separated from the nucleic acid sample with a detector. Kits and instructions for use are also described.

Classes IPC  ?

  • G01N 27/447 - Systèmes utilisant l'électrophorèse
  • C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]

58.

USE OF CUSTOM-DESIGNED PEPTIDES FOR MASS CALIBRATION

      
Numéro d'application IB2024055867
Numéro de publication 2024/257055
Statut Délivré - en vigueur
Date de dépôt 2024-06-14
Date de publication 2024-12-19
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Pillai, Sasikumar

Abrégé

Calibrant compositions comprising a plurality of synthetic peptides for calibration of a mass spectrometer in either positive or negative mode are provided. The synthetic peptide calibrants exhibit desirable ionization characteristics, solubility, and solution stability, and are easily washed out of the system such that no interfering signals are left behind. Methods for calibration of mass spectrometer in positive or negative ion mode using a single calibrant composition are also provided.

Classes IPC  ?

  • G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides

59.

METHODS AND SYSTEMS FOR DETERMINING MOLECULAR MASS

      
Numéro d'application 18689495
Statut En instance
Date de dépôt 2022-09-09
Date de la première publication 2024-12-12
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Duchoslav, Eva
  • Le Blanc, Yves

Abrégé

Methods and systems for adjusting instrument setting, improving fidelity of isotope pattern for mass spectra, and/or determining molecular mass with improved accuracy are disclosed. In one example, a method for determining Mmono of a compound of interest in a sample using a mass spectrometer is provided. The method comprises: (1) tuning or adjusting instrument setting of the mass spectrometer using at least one known compound, wherein the instrument setting comprises at least one parameter for improving accuracy; (2) analyzing the compound of interest using the adjusted instrument setting to obtain a mass spectrum thereof, wherein the mass spectrum comprises an isotope pattern thereof; and determining the Mmono of the compound of interest from the mass spectrum thereof.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

60.

METHOD FOR ENHANCING INFORMATION IN DDA MASS SPECTROMETRY

      
Numéro d'application 18686385
Statut En instance
Date de dépôt 2022-08-16
Date de la première publication 2024-12-05
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Tate, Stephen A.

Abrégé

Systems and methods are disclosed for performing a DDA mass spectrometry experiment. A precursor ion survey scan of a mass range is performed to generate a precursor ion peak list. A series of steps are performed for each precursor ion peak of the peak list. A peak mass range including the precursor ion peak is selected. A precursor ion mass selection window with a width smaller than the peak mass range is canned across the peak mass range in overlapping steps, producing a series of overlapping windows across the peak mass range. Each overlapping precursor ion mass selection window of the series is fragmented. Product ions produced from each overlapping precursor ion mass selection window of the series are mass analyzed, producing a product ion spectrum for each overlapping precursor ion mass selection window of the series and a plurality of product ion spectra for the peak.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/40 - Spectromètres à temps de vol
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

61.

SYSTEMS AND METHODS FOR SIGNAL DECONVOLUTION FOR NON-CONTACT SAMPLE EJECTION

      
Numéro d'application 18694178
Statut En instance
Date de dépôt 2022-09-23
Date de la première publication 2024-12-05
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Liu, Chang

Abrégé

A method for determining a convolved peak intensity in a sample trace includes ejecting a plurality of sample ejections from a sample well plate. An ejection time log is generated which includes an ejection time of each of the plurality of sample ejections from the sample well plate. The plurality of sample ejections is analyzed with a mass analyzer. The sample trace of intensity versus time values is produced for the plurality of sample ejections based on the analysis. A known peak shape is obtained. A convolved peak intensity is determined for a convolved peak of the sample trace based at least in part on the known peak shape and the ejection time log.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

62.

Ms/Ms-Based Identification of Trisulfide Bonds

      
Numéro d'application 18694233
Statut En instance
Date de dépôt 2022-09-21
Date de la première publication 2024-12-05
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Zhang, Yuzhuo

Abrégé

Methods and system that determines disulfide and trisulfide linkages within analytes (e.g., polypeptides) is described. In certain aspects. a sample comprising polypeptides (such as an antibody) may be subjected to dissociation using an electron activated dissociation (which can include electron capture dissociation and electron transfer dissociation) and the fragmentated portions are analyzed using a mass spectrometer to produce a spectrum. The spectrum is analyzed by a processor to identify peaks from the spectrum that are related to one another in the spectra by a separation of 32 mass units. In identifying an antibody comprising peptide segments linked via a trisulfide bond. for example, four different peaks representing two different peptides are searched for and identified representing a first peptide portion having mass/charge of A and A+32 and a second peptide having mass/charge of B and B+32.

Classes IPC  ?

  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
  • G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
  • G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

63.

METHODS AND SYSTEMS FOR PROCESSING IN REAL-TIME AND USING GAUSSIAN

      
Numéro d'application 18698102
Statut En instance
Date de dépôt 2022-10-03
Date de la première publication 2024-12-05
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Bradau, Calin
  • Binko, Thomas
  • Albeanu, Nicolae

Abrégé

Systems and methods are provided for processing in real-time and using Gaussian fitting digitized signals from ions detection in time-of-flight (TOP) mass spectrometry. Acquisition/analog-to-digital conversion may be applied in the course of Ion detection during time-of-flight (TOP) mass spectrometry, with the acquisition/analog-to-digital conversion including generating, in response to detection of ions, one or more time-of-flight (TOP) based signals, and digitizing, using analog-to-digital conversion, the one or more TOP based signals, to generate corresponding digitized data. The digitized data may then be processed, in real-time and based on use of Gaussian fitting, to generate result data corresponding to the time-of-flight (TOP) mass spectrometry. The Gaussian fitting may comprise applying second (2nd) degree polynomial fit, such as by least squares via QR factorization.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
  • H01J 49/40 - Spectromètres à temps de vol

64.

METHODS AND SYSTEMS FOR BACKGROUND PROCESSING FOR COVALENT BINDING DETERMINATION

      
Numéro d'application IB2024055323
Numéro de publication 2024/246845
Statut Délivré - en vigueur
Date de dépôt 2024-05-31
Date de publication 2024-12-05
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Liu, Chang
  • Wen, Xiujuan
  • Mclaren, David G.

Abrégé

Methods and systems for background processing include ionizing a first sample and a second sample, the first sample including the target molecule, and the second sample including a target molecule-ligand combination, capturing a raw mass spectrum for the ionized first sample and second sample, generating a deconvoluted mass spectrum for the first sample and the second sample, determining an intensity ratio of a background intensity at a mass window corresponding to a sum of a mass of the target molecule and a mass of the ligand in the first sample to a signal intensity at a mass window corresponding to the target molecule in the first sample, and determining, based on the determined intensity ratio, a background intensity of the target molecule- ligand combination in the deconvoluted mass spectrum of the second sample at a mass window corresponding to the mass of the target molecule-ligand combination.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • C12Q 1/6872 - Méthodes de séquençage faisant intervenir la spectrométrie de masse
  • G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques

65.

SYSTEMS AND METHODS FOR FLASH BOILING OF A LIQUID SAMPLE

      
Numéro d'application 18689467
Statut En instance
Date de dépôt 2022-09-09
Date de la première publication 2024-11-28
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s) Kovarik, Peter

Abrégé

A method of ejecting a sample from a nebulizer nozzle fluidically coupled to a port via a transfer conduit includes receiving at the port a transport liquid and the sample. The transport liquid and the sample in the transfer conduit is transported from the port to a transfer conduit exit comprising an electrode tip. The transport liquid is ejected from the transfer conduit exit. The sample is ejected from the transfer conduit exit substantially simultaneously with ejecting the transport liquid. During ejection of the transport liquid and the sample from the transfer conduit exit, a pressure is generated at the transfer conduit exit substantially similar to a vapor pressure of the transport liquid.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
  • H01J 49/16 - Sources d'ionsCanons à ions utilisant une ionisation de surface, p. ex. émission thermo-ionique ou photo-électrique
  • H01J 49/24 - Systèmes à vide, p. ex. maintenant des pressions voulues

66.

Systems and Methods for Background Ion Detection in Mass Spectrometry

      
Numéro d'application 18693311
Statut En instance
Date de dépôt 2022-09-19
Date de la première publication 2024-11-28
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Liu, Chang
  • Tate, Stephen
  • Zhang, Hui

Abrégé

A method for performing mass spectrometry (MS) comprises receiving MS data corresponding to a plurality of MS runs, wherein MS data corresponding to an MS run of the plurality of MS runs comprises detected intensities for a plurality of mass over charge ratios (MZ values) during the MS run; finding a recurrent MZ value of the plurality of MZ values, wherein a detected intensity for the recurrent MZ value appears as a recurrent peak in MS data corresponding to a subset of the plurality of MS runs; and the subset of the plurality of MS runs includes at least two MS runs of the plurality of MS runs; and identifying the recurrent MZ value as corresponding to a background ion.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

67.

Deflector Gates for Ion Beam Intensity Modulation

      
Numéro d'application 18693363
Statut En instance
Date de dépôt 2022-09-28
Date de la première publication 2024-11-28
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Haufler, Robert
  • Loyd, William

Abrégé

In one aspect, a mass spectrometer is disclosed, which includes an ion path along which an ion beam can propagate, and an ion beam deflector positioned in the ion path and configured to modulate transfer of an ion beam received from an upstream section of the ion path to a downstream section thereof, said ion beam deflector comprising at least one electrically conductive electrode positioned relative to one another to provide an opening through which the ion beam can pass, where the two electrodes are electrically insulated relative to one another so as to allow maintaining each electrode at a DC potential independent of a DC potential at which the other electrode is maintained.

Classes IPC  ?

  • H01J 49/06 - Dispositifs électronoptiques ou ionoptiques
  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails

68.

SYSTEMS AND METHODS FOR LIQUID-TO-LIQUID SAMPLE COLLECTION

      
Numéro d'application IB2024055023
Numéro de publication 2024/241262
Statut Délivré - en vigueur
Date de dépôt 2024-05-23
Date de publication 2024-11-28
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Kovarik, Peter
  • Covey, Thomas R.

Abrégé

A method of sampling with an open port interface (OPI) comprises operating the OPI. A liquid sample is contacted with the OPI. An aliquot from the liquid sample is pinned to the OPI. The aliquot includes a predetermined volume which terminates contact between the OPI and the liquid sample. The aliquot is aspirated from the OPI via a removal conduit within the OPI.

Classes IPC  ?

  • G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

69.

OPTIMIZATION OF DMS SEPARATIONS USING ACOUSTIC EJECTION MASS SPECTROMETRY (AEMS)

      
Numéro d'application 18686618
Statut En instance
Date de dépôt 2022-09-07
Date de la première publication 2024-11-14
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Schneider, Bradley B.
  • Bedford, Leigh
  • Liu, Chang

Abrégé

Disclosed are methods and systems that provide for the analysis of one or more analytes of interest in an acoustic ejection mass spectrometer (AEMS) system that incorporates an open port interface (OPI) and differentiation mass spectrometry (DMS) that allows for operation of the system in a pseudo-continuous mode to scan and determine optimal DMS settings for the one or more analytes of interest, and for operation of the system in a discontinuous mode to analyze for the presence of the one or more analytes of interest in a sample.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
  • G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

70.

SPECTRAL COMPARISON

      
Numéro d'application 18691598
Statut En instance
Date de dépôt 2022-09-15
Date de la première publication 2024-11-14
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Liu, Chang
  • Ivosev, Gordana
  • Zhang, Hui

Abrégé

Methods and systems for spectral comparison and quality assessment are disclosed. In one example, a method for assessing quality of a mass spectrum (MS) of a sample is provided. The method comprises: predefining one or more features or attributes indicative of the sample quality with reference to a target compound; and calculating a quality score for the MS with respect to the selected features or attributes.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

71.

THREE-DIMENSIONAL CHEMICAL PEAK FINDER FOR QUALITATIVE AND QUANTITATIVE ANALYTICAL WORKFLOWS

      
Numéro d'application 18689600
Statut En instance
Date de dépôt 2022-09-09
Date de la première publication 2024-11-14
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Duchoslav, Eva
  • Narayanaswamy, Pradeep
  • Tate, Stephen

Abrégé

Methods and systems for identifying analytes in a sample using mass spectrometry are provided. A method for identifying analytes in mass spectrometry data comprises: introducing a sample to a mass spectrometer; analyzing the sample with the mass spectrometer in a plurality of cycles; generating, for each cycle, a mass spectrum comprising at least one peak; annotating peaks in the mass spectrum based on their relationships; assigning best ion types to each peak; processing each cycle of the mass spectrum to assign a score to each of the at least one peak thereof with respect to the likely neutral mass related to the peak; grouping peaks that share a common neutral mass; and outputting the analyte neutral mass.

Classes IPC  ?

  • G01N 30/72 - Spectromètres de masse
  • B01D 15/08 - Adsorption sélective, p. ex. chromatographie
  • G01N 30/02 - Chromatographie sur colonne
  • G01N 30/86 - Analyse des signaux
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

72.

ION TYPE TAILORED LIBRARY SEARCH PRE-PROCESSING, CONSTRAINTS AND SPECTRAL DATABASE BUILDING

      
Numéro d'application 18689522
Statut En instance
Date de dépôt 2022-09-08
Date de la première publication 2024-11-07
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Duchoslav, Eva
  • Narayanaswamy, Pradeep
  • Tate, Stephen

Abrégé

Methods and systems for building and using an analyte library are provided. One aspect is a method for building an analyte library, the method comprising receiving mass spectrum data from analysis of a sample using mass spectrometry, mass spectrum data including a mass spectrum and a sample matrix, and the sample including an analyte, identifying peaks in the mass spectrum, assigning at least one ion type to the peaks, annotating the peaks for the analyte based on the sample matrix, extracting an ion fingerprint for the analyte based on the annotated peaks and storing an analyte identification entry including the ion fingerprint for the analyte.

Classes IPC  ?

  • G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
  • G16B 40/20 - Analyse de données supervisée
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

73.

BEAM HOMOGENIZATION FOR TRAPPED ION PROCESSING WITH DISCRETE ION PACKETS

      
Numéro d'application IB2024054082
Numéro de publication 2024/224352
Statut Délivré - en vigueur
Date de dépôt 2024-04-26
Date de publication 2024-10-31
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Ryumin, Pavel
  • Jin, Wen
  • Chernushevich, Igor
  • Baba, Takashi

Abrégé

In one aspect, a mass spectrometer is disclosed, which includes an ion trapping device, at least one pressurized ion guide configured to allow establishment of an adjustable axial field therein such that the axial field can be adjusted to operate the pressurized ion guide in any of a fast and a slow operational setting, a mass analyzer for receiving ions passing through the pressurized ion guide and configured to provide mass analysis of the received ions, and a controller in communication with said at least one pressurized ion guide for causing the adjustment of the axial field so as to switch the operational setting of the pressurized ion guide between the fast and the slow operational settings based on an operational mode of the mass spectrometer.

Classes IPC  ?

  • H01J 49/06 - Dispositifs électronoptiques ou ionoptiques
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

74.

AUTOMATED MULTIPLE LINEAR REGRESSION FOR CALIBRATION CURVES

      
Numéro d'application IB2024054102
Numéro de publication 2024/224368
Statut Délivré - en vigueur
Date de dépôt 2024-04-26
Date de publication 2024-10-31
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Cox, David Michael
  • Anichina, Janna

Abrégé

A method of calibrating a signal measurement system includes performing a first number of calibration measurements for a first number of samples of a compound, the samples having known concentrations, by measuring a signal for each sample, receiving a signal for a sample having an unknown concentration of the compound; selecting a second number of calibration measurements from the first number of calibration measurements, the second number being smaller than the first number; performing a regression on the selected second number of calibration measurements; and determining the unknown concentration based on the performed regression.

Classes IPC  ?

75.

DATA INDEPENDENT ACQUISITION OF PRODUCT ION SPECTRA AND REFERENCE SPECTRA LIBRARY MATCHING

      
Numéro d'application 18760778
Statut En instance
Date de dépôt 2024-07-01
Date de la première publication 2024-10-24
Propriétaire
  • DH Technologies Development Pte. Ltd. (Singapour)
  • ETH Zurich (Suisse)
Inventeur(s)
  • Bonner, Ronald F.
  • Tate, Stephen A.
  • Aebersold, Rudolf
  • Navarro Alvarez, Pedro Jose
  • Rinner, Oliver
  • Reiter, Lukas
  • Gillet, Ludovic

Abrégé

Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • G01N 30/72 - Spectromètres de masse
  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
  • G16C 20/90 - Langages de programmationArchitectures informatiquesSystèmes de bases de donnéesStockage de données
  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

76.

Extending Operational Lifetime of a Mass Spectrometer

      
Numéro d'application 18685534
Statut En instance
Date de dépôt 2022-08-23
Date de la première publication 2024-10-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Cox, David M.
  • Guna, Mircea
  • Kang, Yang
  • Manolescu, Mircea
  • Sonoc, Andrei

Abrégé

An ion mass filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to generate an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto, and at least two pairs of auxiliary electrodes interspersed between the plurality of multipole rods, where one pair forms a first pole of the auxiliary electrodes and the other pair forms a second pole of the auxiliary electrodes. A controller can provide one or more control signals to the DC voltage source so as to switch the polarity of the DC voltage differential between the two poles according to a predefined criterion.

Classes IPC  ?

  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons

77.

PREDICTION OF PRECURSOR CHARGE STATE IN DM-SWATH ANALYSIS

      
Numéro d'application 18688423
Statut En instance
Date de dépôt 2022-09-02
Date de la première publication 2024-10-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Le Blanc, Yves
  • Ivosev, Gordana

Abrégé

A method for improved mass spectrometry by determining charge state of precursor ions from an analysis of product ions, includes receiving sample ions. A group of precursor ions is selected from the received sample ions based on mobility. A fragmentation device fragments the group of precursor ions to produce a group of product ions. A tandem mass spectrometry analysis is performed on the group of product ions to generate an intensity and mass-to-charge ratio (m/z) of the group of product ions. An ionogram is generated, based on the generated intensities and mass, to charge ratios for the groups of product ions generated for each of the mobility selection. The ionogram includes a first axis representing compensation voltage value and another axis representing intensity. A product ion peak is identified in the ionogram. At least one peak characteristic is identified of the product ion peak. A charge state of a precursor ion that was fragmented to form the product ions represented in the product ion peak is determined based on the at least one peak characteristic of the produce ion peak.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • G01N 27/623 - Spectrométrie de mobilité ionique combinée à la spectrométrie de masse
  • G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]

78.

Determination of Ion Control for Detector Life Time and Provision for Notice To End User

      
Numéro d'application 18693343
Statut En instance
Date de dépôt 2022-09-21
Date de la première publication 2024-10-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Chelur, Anjali
  • Tate, Stephen

Abrégé

In one aspect, a method of operating a mass spectrometer is disclosed, which comprises ionizing a sample to generate a plurality of ions, and introducing at least a portion of the ions into an inlet orifice of the mass spectrometer. At least a portion of the ions and/or fragments thereof is detected by a downstream detector to generate a plurality of ion detection events, and the ion detection events are monitored to determine an ion count. The ion count is compared with a reference level to determine whether the detected level exceeds the reference level.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

79.

An Improved Ion Guide Bandpass Filter

      
Numéro d'application 18685356
Statut En instance
Date de dépôt 2022-08-23
Date de la première publication 2024-10-24
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Cox, David M.
  • Faur, Manuel
  • Guna, Mircea
  • Kang, Yang
  • Sonoc, Andrei

Abrégé

In one aspect, an ion filter for use in a mass spectrometer is disclosed, which includes a plurality of rods arranged in a multipole configuration to provide a passageway through which ions can travel, said plurality of rods being configured for application of RF voltages thereto to provide an electromagnetic field within the passageway for providing radial confinement of the ions and further configured for application of a DC voltage thereto. At least two pairs of auxiliary electrodes are interspersed between the plurality of rods and are configured for application of a DC bias voltage with one polarity to one of said pairs and a DC bias voltage with an opposite polarity to the other one of said pairs to provide a DC potential difference between the auxiliary electrodes and the plurality of rods.

Classes IPC  ?

  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

80.

SCOUT MRM FOR SCREENING AND DIAGNOSTIC ASSAYS

      
Numéro d'application 18577407
Statut En instance
Date de dépôt 2022-07-05
Date de la première publication 2024-10-17
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Purkayastha, Subhasish
  • Le Blanc, Yves

Abrégé

One or more known compounds are separated from a mixture using a separation device that allows processor-controlled adjustment of a separation parameter. The separated compounds are ionized and, for each cycle of a plurality of cycles, a mass spectrometer executes on the ion beam a series of MRM transitions read from a list. Two or more contiguous groups of MRM transitions to be monitored separately are received. Each group includes at least one sentinel transition that identifies a next group that is to be monitored and identifies a value for the separation parameter for the next group. A first group is placed on the list. When a sentinel transition of the first group is detected, a next group identified by the sentinel transition is placed on the list and the separation parameter is adjusted to a value identified by the sentinel transition for the next group.

Classes IPC  ?

  • G01N 30/72 - Spectromètres de masse
  • B01D 15/08 - Adsorption sélective, p. ex. chromatographie
  • G01N 30/86 - Analyse des signaux
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

81.

CHEMICAL PEAK FINDER MODEL FOR UNKNOWN COMPOUND DETECTION AND IDENTIFICATION

      
Numéro d'application 18689543
Statut En instance
Date de dépôt 2022-09-08
Date de la première publication 2024-10-17
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Duchoslav, Eva
  • Narayanaswamy, Pradeep
  • Tate, Stephen

Abrégé

Methods and systems for identifying one or more analytes in a sample are provided. One aspect is a method of predicting an identity of analytes in an unknown sample, the method comprising accessing a database comprising a plurality of results from analyzing samples using mass spectrometry to identify analytes, the plurality of results including annotated ion fingerprints, training a machine learning model with the plurality of results, and applying the machine learning model to the unknown sample to predict an identity of one or more analytes in the unknown sample.

Classes IPC  ?

  • G16C 20/20 - Identification d’entités moléculaires, de leurs parties ou de compositions chimiques
  • G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

82.

INTENSITY-INDEPENDENT PRECURSOR INFERENCE IN MASS SPECTROSCOPY

      
Numéro d'application 18682218
Statut En instance
Date de dépôt 2022-08-10
Date de la première publication 2024-10-17
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Bloomfield, Nic

Abrégé

Methods for correlating a product ion in a mass spectrum to a precursor ion are disclosed herein, comprising determining a precursor ion ml z corresponding to the product ion as an m/z at which the product ion appears in a maximum amount of the series of mass spectra. Methods also can comprise obtaining a series of mass spectra for a sample across a mass range, each of the series of mass spectra having a precursor ion transmission window defined by a width (W) that overlaps with that of at least two of the series of mass spectra by a step size (S).

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

83.

Methods and Systems for Increasing Sensitivity of Direct Sampling Interfaces for Mass Spectrometric Analysis

      
Numéro d'application 18507940
Statut En instance
Date de dépôt 2023-11-13
Date de la première publication 2024-10-17
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Arnold, Don W.
  • Covey, Thomas R.
  • Liu, Chang

Abrégé

Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings, MS-based systems and methods are provided in which the flow of desorption solvent within a sampling probe fluidly coupled to an ion source can be selectively controlled such that one or more analyte species can be desorbed from a sample substrate inserted within the sampling probe within a decreased volume of desorption solvent for subsequently delivery to the ion source. In various aspects, sensitivity can be increased due to higher desorption efficiency (e.g., due to increased desorption time) and/or decreased dilution of the desorbed analytes. The methods and systems described herein can additionally or alternatively provide for the selective control of the flow rate of the desorption solvent within the sampling interface so as to enable additional processing steps to occur within the sampling probe (e.g., multiple samplings, reactions).

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
  • G01N 1/40 - Concentration des échantillons
  • G01N 30/00 - Recherche ou analyse de matériaux par séparation en constituants utilisant l'adsorption, l'absorption ou des phénomènes similaires ou utilisant l'échange d'ions, p. ex. la chromatographie
  • H01J 49/16 - Sources d'ionsCanons à ions utilisant une ionisation de surface, p. ex. émission thermo-ionique ou photo-électrique

84.

CHROMATOGRAPHIC-LIKE SEPARATION USING SAMPLE DROPLET EJECTION

      
Numéro d'application 18294348
Statut En instance
Date de dépôt 2022-08-04
Date de la première publication 2024-10-17
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Cox, David
  • Liu, Chang

Abrégé

Disclosed are methods for separating target and non-target analytes in a sample. The methods can utilize an acoustic droplet ejector (ADE) and an open port interface (OPI) to achieve liquid chromatography (LC)-like separation for an analytical instrument such as, for example, a mass spectrometer.

Classes IPC  ?

  • G01N 30/72 - Spectromètres de masse
  • G01N 30/02 - Chromatographie sur colonne
  • G01N 30/06 - Préparation
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

85.

Automated analysis of complex matrices using mass spectrometer

      
Numéro d'application 17682960
Numéro de brevet RE050171
Statut Délivré - en vigueur
Date de dépôt 2022-02-28
Date de la première publication 2024-10-15
Date d'octroi 2024-10-15
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s) Kieser, Byron

Abrégé

Improved systems, apparatus, methods, and programming useful for the automated analysis of complex compounds using mass spectrometers. Systems, apparatus, methods, and programming according to the invention provide for the automatic determination by a controller 54 of a mass spectrometer 14, 214 of an analysis operation to be implemented using the mass spectrometer, the analysis operation adapted specifically for analysis of one or more substances based contained within a compound based on identification of the compound and/or substances provided by a user of the spectrometer, and a database 66 or other library of information concerning suitable processes or process steps for analyzing substances.

Classes IPC  ?

  • B01D 59/44 - Séparation par spectrographie de masse

86.

STANDARD ADDITION WORKFLOW FOR QUANTITATIVE ANALYSIS

      
Numéro d'application 18294386
Statut En instance
Date de dépôt 2022-08-05
Date de la première publication 2024-10-10
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Covey, Thomas R.
  • Cox, David Michael
  • Jarvis, Michael
  • Liu, Chang

Abrégé

A method for measuring a concentration of an analyte in a sample includes: sampling, from a first sample, a first one or more droplets for mass analysis, wherein the first sample includes the sample; performing mass analysis on the first one or more droplets to determine a first intensity of an analyte in the first one or more droplets; sampling, from a second sample, a second one or more droplets for mass analysis, wherein the sec-ond sample includes the sample and a first spike of the analyte; performing mass analysis on the second one or more droplets to determine a second intensity of the analyte in the second one or more droplets; fitting a curve to the first intensity and the second intensity; and based on the fitted curve, calculating an analyte concentration for the sample.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/16 - Sources d'ionsCanons à ions utilisant une ionisation de surface, p. ex. émission thermo-ionique ou photo-électrique

87.

CORRECTION OF RETENTION TIME DRIFT WITH SCOUT-MRM

      
Numéro d'application IB2024053309
Numéro de publication 2024/209396
Statut Délivré - en vigueur
Date de dépôt 2024-04-04
Date de publication 2024-10-10
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Burton, Lyle Lorrence
  • Cox, David M.
  • Ivosev, Gordana
  • Leblanc, Yves

Abrégé

Systems and methods are provided for correcting a measured retention time or expected retention time of an ion intensity measurement. A measured sentinel retention time is received for each of a plurality of sentinel ion intensity measurements. During acquisition, sentinel analysis is performed. In sentinel analysis, a plurality of ion intensity measurements is divided into two or more groups so that different groups of the two or more groups are measured separately. At least one sentinel ion intensity measurement in each group of the two or more groups is selected to identify a next group of the two or more groups to be measured. A measured retention time or an expected retention time of at least one non-sentinel ion intensity measurement of the two or more groups is corrected using the plurality of measured sentinel retention times.

Classes IPC  ?

88.

SYSTEMS AND METHODS FOR HANDLING AND ANALYZING SAMPLES

      
Numéro d'application 18579231
Statut En instance
Date de dépôt 2022-07-14
Date de la première publication 2024-10-03
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Covey, Thomas R.
  • Liu, Chang

Abrégé

Methods and systems for handling and/or analyzing samples are provided. In one example, a method comprises: introducing (406), with a liquid handler (322), at least one assisting agent into a sample well (310) of a well plate (312), wherein the sample comprises a sample volume; and ejecting (408), with an acoustic droplet ejector, ADE, (306), a mixture comprising the sample mixed with the at least one assisting agent from the sample well, wherein the at least one assisting agent interacts (406) with an analyte of the sample to limit gel formation at a top surface of the sample volume, prior to the mixture ejection.

Classes IPC  ?

  • B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques

89.

IDENTIFICATION OF AMINO ACID ISOMERS USING DIAGNOSTIC FRAGMENT IONS IN MS/MS DATA

      
Numéro d'application 18588316
Statut En instance
Date de dépôt 2024-02-27
Date de la première publication 2024-10-03
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Boudreau, Armandine
  • Hamada, Mona
  • Sciuto, Stephen

Abrégé

Computer-implemented methods and non-transitory computer readable storage media for isobaric amino acid differentiation, where an MS/MS data set may be processed, wherein the processing includes determining whether a protein sample comprises at least one isobaric amino acid, analyzing whether any diagnostic fragment ions of the at least one isobaric amino acid are present in the protein sample, assigning a score to the at least one isobaric amino acid based on the diagnostic fragment ions present in the MS/MS data set, evaluating the identity of the at least one isobaric amino acid present in the protein sample based on the assigned score, and reporting the evidence of the identity of the at least one isobaric amino acid present in the protein sample.

Classes IPC  ?

  • G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase

90.

METHOD FOR REAL TIME ENCODING OF SCANNING SWATH DATA AND PROBABILISTIC FRAMEWORK FOR PRECURSOR INFERENCE

      
Numéro d'application 18739836
Statut En instance
Date de dépôt 2024-06-11
Date de la première publication 2024-10-03
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Bloomfield, Nic G.
  • Ivosev, Gordana

Abrégé

A precursor ion transmission window is moved in overlapping steps across a precursor ion mass range. The precursor ions transmitted at each overlapping step by the mass filter are fragmented or transmitted. Intensities or counts are detected for each of the one or more resulting product ions or precursor ions for each overlapping window that form mass spectrum data for each overlapping window. Each unique product ion detected is encoded in real-time during data acquisition. This encoding includes sums of counts or intensities of each unique ion detected the overlapping windows and positions of the windows associated with each sum. The encoding for each unique ion is stored in a memory device rather than the mass spectral data. A deblurring algorithm or numerical method is used to determine a precursor ion of each unique ion from the encoded data.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • G06F 17/16 - Calcul de matrice ou de vecteur
  • G06F 17/17 - Évaluation de fonctions par des procédés d'approximation, p. ex. par interpolation ou extrapolation, par lissage ou par le procédé des moindres carrés

91.

GENERIC PEAK FINDER

      
Numéro d'application 18293148
Statut En instance
Date de dépôt 2022-07-28
Date de la première publication 2024-10-03
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Duchoslav, Eva

Abrégé

A method for identifying peaks in a mass spectrum is provided. The method includes: accessing a mass spectrum (300), having an intensity signal, generated for analysis of a sample; performing a wavelet transformation on the intensity signal to generate a wavelet space representation (310) of the intensity signal; generating a scale-space-processing (SSP) response signal (412, 414, 416) from the wavelet space representation of the intensity signal, wherein the SSP response signal (412, 414, 416) represents the SSP response from the wavelet scale representation (310) at different wavelet scales for a particular m/z starting position (312, 314, 316); identifying a first wavelet scale for a first local maximum in the SSP response signal; based on the first wavelet scale, detect a first baseline intensity signal; subtracting the first baseline intensity signal from the intensity signal to generate a first adjusted intensity signal; and detecting one or more peaks in the first adjusted intensity signal.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • G06V 10/52 - Analyse spatiale multi-échelle, p. ex. analyse par ondelettes

92.

LIQUID TRANSPORT SYSTEM HAVING MULTIPLE NEBULIZER NOZZLES

      
Numéro d'application 18293399
Statut En instance
Date de dépôt 2022-07-28
Date de la première publication 2024-10-03
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Kovarik, Peter
  • Corr, John J.

Abrégé

A liquid handling system for a mass spectrometer (MS), the liquid handling system including an open port interface (OPI) including a body defining a port and an internal volume. At least one removal conduit is disposed in the body and fluidically coupled to the internal volume. A plurality of transfer conduits is fluidically coupled to the at least one removal conduit. A single one of a plurality of nebulizer nozzles are fluidically coupled to each of the plurality of transfer conduits.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
  • H01J 49/16 - Sources d'ionsCanons à ions utilisant une ionisation de surface, p. ex. émission thermo-ionique ou photo-électrique

93.

SYSTEMS AND METHODS FOR PURITY CALCULATION FOR THE COMPOUND QC WORKFLOW

      
Numéro d'application IB2024052652
Numéro de publication 2024/194800
Statut Délivré - en vigueur
Date de dépôt 2024-03-19
Date de publication 2024-09-26
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Liu, Chang

Abrégé

A method for quantifying a purity of a target analyte in a sample includes introducing into a mass spectrometer, via a sample introduction, a plurality of sample ions generated by ionizing at least a portion of analytes in the sample; obtaining, via the mass spectrometer, a plurality of mass spectra including a sample mass spectrum associated with the sample introduction; analyzing the sample mass spectrum to identify a target signal corresponding to the target analyte; deriving, from the target signal, a target signal intensity corresponding to the target analyte; deriving, from at least a portion of the sample mass spectrum, a sample signal intensity; and quantifying the purity of the target analyte based on the target signal intensity and the sample signal intensity.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

94.

MULTIDIMENSIONAL VARIABLE SCANNING SWATH MASS SPECTROMETRY

      
Numéro d'application IB2024052653
Numéro de publication 2024/194801
Statut Délivré - en vigueur
Date de dépôt 2024-03-19
Date de publication 2024-09-26
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Tate, Stephen
  • Bloomfield, Nicholas G.

Abrégé

In one aspect, a method of acquiring mass data in a mass spectrometric system is disclosed, which includes introducing a plurality of ions into a mass filter providing a mass selection window to allow passage of precursor ions having m/z ratios within the mass selection window through the mass filter and scanning the mass selection window and adjusting a width thereof across a mass range during acquisition of mass data.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

95.

SYSTEMS AND METHODS FOR AUTO-GENERATION OF ION LIST

      
Numéro d'application IB2024052651
Numéro de publication 2024/194799
Statut Délivré - en vigueur
Date de dépôt 2024-03-19
Date de publication 2024-09-26
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Ivosev, Gordana
  • Liu, Chang

Abrégé

A method for determining a composition of a sample utilizing mass spectrometry includes introducing a plurality of sample ions, obtaining a plurality of mass spectra including a sample introduction mass spectrum associated with the sample introduction event, identifying a set of background signals, identifying a set of sample ion signals by removing background ions, and deriving, from the set of sample ion signals, an ion list corresponding to the composition of the sample.

Classes IPC  ?

  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

96.

METHOD AND SYSTEM FOR INTRODUCING MODIFIER INTO A CURTAIN GAS STREAM FOR A DIFFERENTIAL MOBILITY SPECTROMETER

      
Numéro d'application IB2024052723
Numéro de publication 2024/194832
Statut Délivré - en vigueur
Date de dépôt 2024-03-21
Date de publication 2024-09-26
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Bazargan, Samad
  • Corr, John J.

Abrégé

In one aspect, a mass spectrometer system includes an ion mobility spectrometer (IMS), a gas supply for providing a curtain gas, a modifier supply for providing a liquid modifier, and a nebulizer for receiving the liquid modifier from the modifier supply and generating liquid droplets for delivery to a curtain chamber of the IMS. The spectrometer includes a fluid manifold for receiving the liquid modifier and delivering the liquid modifier to the nebulizer and to receive the curtain gas from the gas supply and provide a first portion of the curtain gas to the nebulizer as a nebulizing gas and provide a second portion of the curtain gas as a sheath flow to a region in vicinity of a nozzle of the nebulizer such that a combination of the sheath flow and gas exiting the nebulizer flows as a curtain gas entraining the liquid droplets to the curtain chamber.

Classes IPC  ?

  • G01N 27/623 - Spectrométrie de mobilité ionique combinée à la spectrométrie de masse
  • B05B 5/00 - Pulvérisation électrostatiqueDispositifs de pulvérisation comportant des moyens pour charger électriquement le pulvérisatPulvérisation de liquides ou d'autres matériaux fluides par voies électriques

97.

METHOD AND SYSTEM FOR TIMED INTRODUCTION OF SAMPLE INTO A MASS SPECTROMETER

      
Numéro d'application 18268438
Statut En instance
Date de dépôt 2021-09-24
Date de la première publication 2024-09-19
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Kovarik, Peter
  • Covey, Thomas
  • Ivosev, Gordana
  • Liu, Chang

Abrégé

Systems and methods are disclosed for timed introduction of samples into a mass spectrometer may include receiving a plurality of sample ion pulses in a mass spectrometer from a sampling interface, where the sample ion pulses are received at a pre-determined time pattern; detecting the received sample ion pulses to generate a signal; isolating an analyte signal by signal conditioning the generated signal based on the pre-determined time pattern; and identifying a presence of an analyte based on the isolated analyte signal. The signal conditioning may include pulse-based averaging based on the pre-determined time pattern or may include converting the generated signal to a frequency-domain signal and calculating a modulus to isolate the analyte signal. The pre-determined time pattern may be periodic where the signal conditioning comprises performing a Fourier Transform on the signal to convert it to a frequency-domain signal.

Classes IPC  ?

  • H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules

98.

Space Charge Reduction in TOF-MS

      
Numéro d'application 18681206
Statut En instance
Date de dépôt 2022-08-03
Date de la première publication 2024-09-19
Propriétaire DH Technologies Development Pte. Ltd. (Singapour)
Inventeur(s)
  • Ryumin, Pavel
  • Bloomfield, Nichols G.
  • Chernushevich, Igor

Abrégé

A mass spectrometer that includes a mass filter and a TOF mass analyzer receives the ion beam from an ion source device that ionizes a compound of a sample. The mass filter selects a precursor ion mass range and the mass analyzer mass analyzes the mass range. A continuous flow of selected precursor ions is maintained between the mass filter and the mass analyzer. A first set of parameters is applied to the mass spectrometer to produce a resolution above a first resolution threshold. A space charge effect is detected by determining if the measured TIC exceeds a TIC threshold or the measured resolution is less than the first resolution threshold. If a space charge effect is detected, at least one precursor ion transmission window with a width smaller than the mass range is applied to the ion beam by the mass filter and mass analyzed to reduce the space charge.

Classes IPC  ?

  • H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons
  • H01J 49/00 - Spectromètres pour particules ou tubes séparateurs de particules
  • H01J 49/40 - Spectromètres à temps de vol

99.

POWER SUPPLY INCLUDING AMPLITUDE CALIBRATION AND PHASE CORRECTION FOR MASS SPECTROMETRY

      
Numéro d'application IB2024051973
Numéro de publication 2024/184761
Statut Délivré - en vigueur
Date de dépôt 2024-02-29
Date de publication 2024-09-12
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Tudor, Andrei
  • Gera, Tiberiu

Abrégé

In one aspect, a circuit for generating an asymmetric waveform for application to electrodes of a differential mobility mass (DMS) spectrometer is disclosed, which includes two digital waveform synthesizers for generating digital waveforms, which are converted to analog waveforms for application to electrodes of the DMS spectrometer. Analog feedback signals associated with the applied waveforms are digitized into digital amplitude calibration feedback signals and digital phase correction feedback signals. An amplitude calibration circuit is employed apply an RF calibration factor to at least one of the digital waveform synthesizers based on digital the amplitude calibration feedback signals. A digital passband filter is employed to filter the digital phase correction feedback signals, which are then employed to determine a phase correction signal for application to at least one of the digital waveform synthesizers for maintaining a substantially constant phase difference between the waveforms generated by the digital waveform synthesizers.

Classes IPC  ?

  • G01N 27/624 - Spectrométrie de mobilité ionique différentielle [DMS]Spectrométrie de mobilité ionique à haut champ asymétrique [FAIMS]
  • H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails

100.

CAPILLARY ELECTROPHORESIS METHODS FOR CHARACTERIZING ENCAPSULATED BIOMOLECULES

      
Numéro d'application IB2024052170
Numéro de publication 2024/184827
Statut Délivré - en vigueur
Date de dépôt 2024-03-06
Date de publication 2024-09-12
Propriétaire DH TECHNOLOGIES DEVELOPMENT PTE. LTD. (Singapour)
Inventeur(s)
  • Luo, Jane
  • Yang, Zhichang

Abrégé

The disclosed technology provides methods and kits for analyzing and characterizing biomolecules in communication with a delivery vehicle.

Classes IPC  ?

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