The present invention provides a copolymer obtainable by polymerising monomers comprising benzyl (meth)acrylate, (meth)acrylic acid, polypropylene glycol) (meth)acrylate and optionally one or more additional monomers, wherein if one or more additional monomers are present, the one or more additional monomers are present in a total amount of less than 2% by weight, based on the total weight of the monomers, and wherein the copolymer has an acid value from 1 to 3 mmol/g. The invention also provides a pigment dispersion comprising: a continuous aqueous phase; a pigment; and a copolymer of the invention. The invention further provides a method of preparing a pigment dispersion, the method comprising mixing a pigment with a copolymer of the invention in a continuous aqueous phase, and a pigment dispersion obtainable by this method. The invention additionally provides an inkjet ink comprising the pigment dispersion of the invention.
C08L 33/06 - Homopolymères ou copolymères des esters d'esters ne contenant que du carbone, de l'hydrogène et de l'oxygène, l'oxygène, faisant uniquement partie du radical carboxyle
C09D 133/06 - Homopolymères ou copolymères d'esters d'esters ne contenant que du carbone, de l'hydrogène et de l'oxygène, l'atome d'oxygène faisant uniquement partie du radical carboxyle
2.
Apparatus for Processing a Liquid Comprising a Target Substance
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Haigh, Jonathan
Nagy, Tibor
Pullen, James
Topping, Andrew
Abrégé
Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided. The apparatus comprises at least a first and a second means for carrying out a unit operation, each means for carrying out a unit operation comprising a feed for a liquid in fluid connection with the inlet of a flow-controller comprising a variable flow inlet valve and an outlet, wherein at least one of the means for carrying out a unit operation comprises feeds for at least two liquids, the feeds being in fluid connection with the inlets of a multiple inlet flow-controller comprising two or more variable flow inlet valves for dosing the at least two liquids, the flow-controller also comprising an outlet; a feed for a liquid feedstock comprising the target substance in fluid connection with the outlet from the flow-controller thereby to enable combination of the feed for a liquid comprising the target substance with the mixed bioprocessing liquids to produce a device feed; a device for achieving a processing operation comprising a device inlet and a device outlet, the device inlet being in fluid connection with the device feed; and a means for imparting flow through the flow controller and from the feed for the liquid feedstock through the processing device via the device inlet; and wherein the feed for a liquid feedstock comprising the target substance for the second means for carrying out a unit operation comprises the outlet from the first means for carrying out a unit operation.
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Mulvihill, Daniel
Baker, Karen
Eastwood, Tara
Lennon, Christopher
Abrégé
Described is a method and component parts of a recombinant expression system for the expression of a biological molecule. In particular, an isolated vesicle nucleating polypeptide (VNp) comprising an amphipathic alpha helix polypeptide derived from the amino terminus of synuclein isoforms and variants thereof is used to promote, enhance or increase the formation of vesicles in the expression system to enable purification of the biological molecule.
C12P 21/00 - Préparation de peptides ou de protéines
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
C12N 15/70 - Vecteurs ou systèmes d'expression spécialement adaptés à E. coli
37 - Services de construction; extraction minière; installation et réparation
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Construction services; building services; construction of
pharmaceutical facilities; onsite management relating to the
construction of pharmaceutical manufacturing facilities;
building and construction of factories; custom construction
of factories and pharmaceutical manufacturing facilities;
information, advice and consultancy in relation to all the
aforesaid. Custom processing and manufacturing services; custom
processing and manufacturing of pharmaceuticals; custom
manufacture of pharmaceuticals; manufacture, processing and
production of recombinant proteins for use in the
biotechnology industries to the order and specification of
others; cell culture manufacturing services for others;
custom manufacture of biologics; information, advice and
consultancy in relation to all the aforesaid. Scientific and technological services; research and
development; scientific, industrial and technical research,
development and analysis services; scientific, industrial
and technical research, development and analysis services in
the field of biotechnology; industrial process development;
development of processes for the use in the manufacture of
biotechnology products; technical project studies;
biotechnology testing; research and consultancy in the field
of biotechnology; research and development in the
pharmaceutical and biotechnology industry; scientific,
technological and pharmaceutical process development and
design; biopharmaceutical product development; software
development, programming and implementation; design and
development of software; design and development of
manufacturing processes in the field of biopharmaceuticals;
design of manufacturing methods; design of industrial
buildings; design of manufacturing plants; engineering
services; research laboratories; preparation of biological
samples for analysis in research laboratories; designs
services relating to process systems for the biotechnology
industry; design services relating to plant for the
biotechnology industry; information, advice and consultancy
in relation to all the aforesaid.
37 - Services de construction; extraction minière; installation et réparation
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
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Construction services; building services; construction of
pharmaceutical facilities; onsite management relating to the
construction of pharmaceutical manufacturing facilities;
building and construction of factories; custom construction
of factories and pharmaceutical manufacturing facilities;
information, advice and consultancy in relation to all the
aforesaid. Custom processing and manufacturing services; custom
processing and manufacturing of pharmaceuticals; custom
manufacture of pharmaceuticals; manufacture, processing and
production of recombinant proteins for use in the
biotechnology industries to the order and specification of
others; cell culture manufacturing services for others;
custom manufacture of biologics; information, advice and
consultancy in relation to all the aforesaid. Scientific and technological services; research and
development; scientific, industrial and technical research,
development and analysis services; scientific, industrial
and technical research, development and analysis services in
the field of biotechnology; industrial process development;
development of processes for the use in the manufacture of
biotechnology products; technical project studies;
biotechnology testing; research and consultancy in the field
of biotechnology; research and development in the
pharmaceutical and biotechnology industry; scientific,
technological and pharmaceutical process development and
design; biopharmaceutical product development; software
development, programming and implementation; design and
development of software; design and development of
manufacturing processes in the field of biopharmaceuticals;
design of manufacturing methods; design of industrial
buildings; design of manufacturing plants; engineering
services; research laboratories; preparations of biological
samples for analysis in research laboratories; designs
services relating to process systems for the biotechnology
industry; design services relating to plant for the
biotechnology industry; information, advice and consultancy
in relation to all the aforesaid.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cell cultures used in industry and science; mammalian cell
cultures and vectors, being independent replicating pieces
of DNA that can transfer DNA sequences, each for manufacture
and development in the biotechnology industries; biological
preparations for use in science; biological preparations for
use in cell cultures; cell culture reagents for scientific
and research use; media for cell culture for use in the
biotechnological industry; chemical products for
biotechnological purposes; chemicals for use in
biotechnological manufacturing processes. Processing and manufacturing of vectors, cell cultures and
recombinant proteins for use in biotechnology industries to
the order and specification of others; manufacture,
processing and production of recombinant proteins for use in
the biotechnology industries to the order and specification
of others; custom processing and manufacturing services in
the field of biopharmaceuticals; custom processing and
manufacturing of biological products; custom manufacture of
biopharmaceuticals; cell culture manufacturing services for
others; custom manufacture of biologics; information, advice
and consultancy in relation to all the aforesaid. Scientific, industrial and technical research, development
and analysis services; development and analysis services
relating to the use of mammalian cell cultures and vectors
in the field of biotechnology; biotechnology process
development; development of processes for the use of
mammalian cell cultures and vectors in the manufacture of
biotechnology products; technical project studies; project
studies relating to the use of mammalian cell cultures and
vectors in the field of biotechnology; development of
processes for the use in the manufacture of biotechnology
products; technical project studies; biotechnology testing;
research and consultancy in the field of biotechnology;
research and development in the pharmaceutical and
biotechnology industry; scientific, technological and
pharmaceutical process development and design;
biopharmaceutical product development; design and
development of manufacturing processes in the field of
biopharmaceuticals; development of chemicals for use in the
manufacture of biotechnology products and pharmaceuticals;
preparation of biological samples for analysis in research
laboratories; information, advice and consultancy in
relation to all the aforesaid.
37 - Services de construction; extraction minière; installation et réparation
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Construction services; building services; construction of
pharmaceutical facilities; onsite management relating to the
construction of pharmaceutical manufacturing facilities;
building and construction of factories; custom construction
of factories and pharmaceutical manufacturing facilities;
information, advice and consultancy in relation to all the
aforesaid. Custom processing and manufacturing services; custom
processing and manufacturing of pharmaceuticals; custom
manufacture of pharmaceuticals; manufacture, processing and
production of recombinant proteins for use in the
biotechnology industries to the order and specification of
others; cell culture manufacturing services for others;
custom manufacture of biologics; information, advice and
consultancy in relation to all the aforesaid. Scientific and technological services; research and
development; scientific, industrial and technical research,
development and analysis services; scientific, industrial
and technical research, development and analysis services in
the field of biotechnology; industrial process development;
development of processes for the use in the manufacture of
biotechnology products; technical project studies;
biotechnology testing; research and consultancy in the field
of biotechnology; research and development in the
pharmaceutical and biotechnology industry; scientific,
technological and pharmaceutical process development and
design; biopharmaceutical product development; software
development, programming and implementation; design and
development of software; design and development of
manufacturing processes in the field of biopharmaceuticals;
design of manufacturing methods; design of industrial
buildings; design of manufacturing plants; engineering
services; research laboratories; preparation of biological
samples for analysis in research laboratories; designs
services relating to process systems for the biotechnology
industry; design services relating to plant for the
biotechnology industry; information, advice and consultancy
in relation to all the aforesaid.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry and science; cell cultures used
in industry and science; biological preparations for use in
science; biological preparations for use in cell cultures;
proteins for use in industry, enzymes; microbial
preparations being chemicals for industry; cultures of
micro-organisms other than for medical or veterinary use;
chemical reagents; organic chemicals for use in science,
namely genes being DNA sequences; plasmids being small
independently replicating pieces of DNA and vectors being
small independently replicating pieces of DNA that can
transfer DNA sequences, being chemicals for use in science;
cell culture reagents for scientific and research use; media
for cell culture for use in the biotechnological industry;
chemical products for biotechnological purposes; chemicals
for use in biotechnological manufacturing processes. Processing and manufacturing of chemicals and proteins;
custom manufacture of chemicals and proteins for use in
biotechnology and pharmaceuticals; manufacture, processing
and production of scientific and industrial products to the
order and specification of others; custom processing and
manufacturing services; custom processing and manufacturing
of biological products; custom manufacture of
biopharmaceuticals; manufacture, processing and production
of recombinant proteins for use in the biotechnology
industries to the order and specification of others; cell
culture manufacturing services for others; custom
manufacture of biologics; information, advice and
consultancy in relation to all the aforesaid. Scientific, industrial and technical research; scientific
analysis; technological analysis services; scientific
research and development; industrial process development;
industrial design services; provision of facilities for
scientific, industrial and technical research and
development; research and development of scientific,
industrial and technical products; technical project
studies; testing of scientific, industrial and technical
products; scientific, industrial and technical research,
development and analysis services in the field of
biotechnology; development of processes for the use in the
manufacture of biotechnology products; project studies;
biotechnology testing; research and consultancy in the field
of biotechnology; research and development in the
pharmaceutical and biotechnology industry; scientific,
technological and pharmaceutical process development and
design; biopharmaceutical product development; design and
development of manufacturing processes in the field of
biopharmaceuticals; development of chemicals for use in the
manufacture of biotechnology products and pharmaceuticals;
preparation of biological samples for analysis in research
laboratories; information, advice and consultancy in
relation to all the aforesaid.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cell cultures used in industry and science; mammalian cell
cultures and vectors, being independent replicating pieces
of DNA that can transfer DNA sequences, each for manufacture
and development in the biotechnology industries; biological
preparations for use in science; biological preparations for
use in cell cultures; cell culture reagents for scientific
and research use; media for cell culture for use in the
biotechnological industry; chemical products for
biotechnological purposes; chemicals for use in
biotechnological manufacturing processes. Processing and manufacturing of vectors, cell cultures and
recombinant proteins for use in biotechnology industries to
the order and specification of others; manufacture,
processing and production of recombinant proteins for use in
the biotechnology industries to the order and specification
of others; custom processing and manufacturing services;
custom processing and manufacturing of biological products;
custom manufacture of biopharmaceuticals; cell culture
manufacturing services for others; custom manufacture of
biologics; information, advice and consultancy in relation
to all the aforesaid. Scientific, industrial and technical research, development
and analysis services; development and analysis services
relating to the use of mammalian cell cultures and vectors
in the field of biotechnology; industrial process
development; development of processes for the use of
mammalian cell cultures and vectors in the manufacture of
biotechnology products; technical project studies; project
studies relating to the use of mammalian cell cultures and
vectors in the field of biotechnology; development of
processes for the use in the manufacture of biotechnology
products; technical project studies; biotechnology testing;
research and consultancy in the field of biotechnology;
research and development in the pharmaceutical and
biotechnology industry; scientific, technological and
pharmaceutical process development and design;
biopharmaceutical product development; design and
development of manufacturing processes in the field of
biopharmaceuticals; development of chemicals for use in the
manufacture of biotechnology products and pharmaceuticals;
preparation of biological samples for analysis in research
laboratories; information, advice and consultancy in
relation to all the aforesaid.
37 - Services de construction; extraction minière; installation et réparation
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Construction services; building services; construction of
pharmaceutical facilities; onsite management relating to the
construction of pharmaceutical manufacturing facilities;
building and construction of factories; custom construction
of factories and pharmaceutical manufacturing facilities;
information, advice and consultancy in relation to all the
aforesaid. Custom processing and manufacturing services; custom
processing and manufacturing of pharmaceuticals; custom
manufacture of pharmaceuticals; manufacture, processing and
production of recombinant proteins for use in the
biotechnology industries to the order and specification of
others; cell culture manufacturing services for others;
custom manufacture of biologics; information, advice and
consultancy in relation to all the aforesaid. Scientific and technological services; research and
development; scientific, industrial and technical research,
development and analysis services; scientific, industrial
and technical research, development and analysis services in
the field of biotechnology; industrial process development;
development of processes for the use in the manufacture of
biotechnology products; technical project studies;
biotechnology testing; research and consultancy in the field
of biotechnology; research and development in the
pharmaceutical and biotechnology industry; scientific,
technological and pharmaceutical process development and
design; biopharmaceutical product development; software
development, programming and implementation; design and
development of software; design and development of
manufacturing processes in the field of biopharmaceuticals;
design of manufacturing methods; design of industrial
buildings; design of manufacturing plants; engineering
services; research laboratories; preparation of biological
samples for analysis in research laboratories; designs
services relating to process systems for the biotechnology
industry; design services relating to plant for the
biotechnology industry; information, advice and consultancy
in relation to all the aforesaid.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cell cultures used in industry and science; mammalian cell cultures and vectors, being independent replicating pieces of DNA that can transfer DNA sequences, each for use in industry and science; biological preparations for use in science; biological preparations for use in cell cultures for use in industry and science; cell culture reagents for scientific and research use; media for cell culture for use in industry and science; chemicals for use in biotechnological product development; chemicals for use in biotechnological manufacturing processes Processing and manufacturing of vectors, cell cultures and recombinant proteins for use in biotechnology industries to the order and specification of others; manufacture, processing and production of recombinant proteins for use in the biotechnology industries to the order and specification of others; custom processing and manufacturing of pharmaceuticals; custom processing and manufacturing of biological products; custom manufacture of biopharmaceuticals; cell culture manufacturing services for others; custom manufacture of biologics; information, advice and consultancy in relation to all the aforesaid Scientific research, industrial research in the field of biomanufacturing, bioprocessing, pharmaceuticals and biopharmaceuticals and technical product research and development services in the field of biomanufacturing, bioprocessing, pharmaceuticals and biopharmaceuticals; development and analysis services relating to the use of mammalian cell cultures and vectors in the field of biotechnology; industrial process development in the field of biomanufacturing, bioprocessing, pharmaceuticals and biopharmaceuticals; development of processes for the use of mammalian cell cultures and vectors in the manufacture of biotechnology products; technical project studies in the field of biomanufacturing, bioprocessing, pharmaceuticals and biopharmaceuticals; technical project studies relating to the use of mammalian cell cultures and vectors in the field of biotechnology; development of processes for the use in the manufacture of biotechnology products; biotechnology product testing services; research and consultancy in the field of biotechnology; research and development in the pharmaceutical and biotechnology industry; development of processes for use in the manufacture of pharmaceutical and biological products; biopharmaceutical product development; design and development of manufacturing processes in the field of biopharmaceuticals; development of chemicals for use in the manufacture of biotechnology products and pharmaceuticals; preparation of biological samples for analysis in research laboratories; information, advice and consultancy in relation to all the aforesaid
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry and science; cell cultures used in industry and science; biological preparations for use in science; biological preparations for use in cell cultures, other than for medical or veterinary purposes; proteins for industrial use; microbial preparations being chemicals for industry; cultures of micro-organisms other than for medical or veterinary use; chemical reagents, other than for medical or veterinary purpose; organic chemicals for use in science, namely genes being DNA sequences; plasmids being small independently replicating pieces of DNA and vectors being small independently replicating pieces of DNA that can transfer DNA sequences, being chemicals for use in science; cell culture reagents for scientific and research use; media for cell culture for use in the biotechnological industry, other than for medical or veterinary use; chemicals for use in biotechnological product development; chemicals for use in biotechnological manufacturing processes. Processing and manufacturing of chemicals and proteins; custom manufacture of chemicals and proteins for use in biotechnology and pharmaceuticals; manufacture, processing and production of scientific and industrial products, namely, recombinant proteins for use in the biotechnology industries to the order and specification of others; custom processing and manufacturing services of chemicals and proteins; custom processing and manufacturing of biological products; custom manufacture of biopharmaceuticals; manufacture, processing and production of recombinant proteins for use in the biotechnology industries to the order and specification of others; cell culture manufacturing services for others; custom manufacture of biologics; information, advice and consultancy in relation to all the aforesaid. Scientific, industrial and technical research in the fields of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals; scientific analysis in the fields of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals; technological analysis services in the fields of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals; scientific research and development; industrial process development in the fields of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals; industrial design services; provision of facilities for scientific, industrial and technical research and development in the fields of biotechnology, bioprocessing, biopharmaceuticals and pharmaceuticals; research and development of scientific, industrial and technical products; technical project studies in the fields of biotechnology, bioprocessing, biopharmaceuticals and pharmaceuticals; testing of scientific, industrial and technical products in the fields of biotechnology, bioprocessing, biopharmaceuticals and pharmaceuticals; scientific research, industrial research in the fields of biotechnology, bioprocessing, biopharmaceuticals and pharmaceuticals and technical product research and development services in the field of biotechnology; development of processes for the use in the manufacture of biotechnology products; technical project studies in the fields of biotechnology, bioprocessing, biopharmaceuticals and pharmaceuticals; biotechnology product testing services; research and consultancy in the field of biotechnology; research and development in the pharmaceutical and biotechnology industry; development of processes for use in the manufacture of pharmaceutical and biological products; biopharmaceutical product development; design and development of manufacturing processes in the field of biopharmaceuticals; development of chemicals for use in the manufacture of biotechnology products and pharmaceuticals; preparation of biological samples for analysis in research laboratories; information, advice and consultancy in relation to all the aforesaid.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom processing and manufacturing of biopharmaceuticals; custom processing and manufacturing of pharmaceuticals; custom manufacture of pharmaceuticals; manufacture, processing and production of recombinant proteins for use in the biotechnology industries to the order and specification of others; cell culture manufacturing services for others; custom manufacture of biologics; information, advice and consultancy in relation to all the aforesaid Scientific and technological services, namely, scientific research, analysis and testing in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; research and development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; scientific analysis in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial and technical research, development and analysis services; scientific, industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use and manufacture of biotechnology products; technical project studies in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use in the manufacture of biotechnology products; biotechnology product testing services; research and consultancy in the field of biotechnology; research and development in the pharmaceutical and biotechnology industry; scientific, technological and pharmaceutical process development and design in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; biopharmaceutical product development; computer software development, programming and implementation for others; design and development of computer software; design and development of manufacturing processes in the field of biopharmaceuticals; design of manufacturing methods; design of industrial buildings; design of manufacturing plants; engineering services in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; medical and biological research laboratory services; preparation of biological samples for analysis in research laboratories; development of processes for use in the manufacture of products in the biotechnology industry; design services relating to manufacturing plants for the biotechnology industry; information, advice and consultancy in relation to all the aforesaid
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cell cultures used in industry and science; mammalian cell cultures and vectors, being independent replicating pieces of DNA that can transfer DNA sequences, each for use in industry and science; biological preparations for use in science; biological preparations for use in cell cultures for use in industry and science; cell culture reagents for scientific and research use; media for cell culture for use in industry and science; chemicals for use in biotechnological product development; chemicals for use in biotechnological manufacturing processes Processing and manufacturing of vectors, cell cultures and recombinant proteins for use in biotechnology industries to the order and specification of others; manufacture, processing and production of recombinant proteins for use in the biotechnology industries to the order and specification of others; custom processing and manufacturing services in the field of biopharmaceuticals; custom processing and manufacturing of biological products; custom manufacture of biopharmaceuticals; cell culture manufacturing services for others; custom manufacture of biologics; information, advice and consultancy in relation to all the aforesaid Scientific research, industrial research in the field of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals and technical product research and development services in the field of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals; development and analysis services relating to the use of mammalian cell cultures and vectors in the field of biotechnology; industrial process development in the field of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals; development of processes for the use of mammalian cell cultures and vectors in the manufacture of biotechnology products; technical project studies in the field of biomanufacturing, bioprocessing, biopharmaceuticals and pharmaceuticals; project studies relating to the use of mammalian cell cultures and vectors in the field of biotechnology; development of processes for the use in the manufacture of biotechnology products; biotechnology product testing services; research and consultancy in the field of biotechnology; research and development in the pharmaceutical and biotechnology industry; development of processes for use in the manufacture of pharmaceutical and biological products; biopharmaceutical product development; design and development of manufacturing processes in the field of biopharmaceuticals; development of chemicals for use in the manufacture of biotechnology products and pharmaceuticals; preparation of biological samples for analysis in research laboratories; information, advice and consultancy in relation to all the aforesaid
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom processing and manufacturing of biopharmaceuticals; custom processing and manufacturing of pharmaceuticals; custom manufacture of pharmaceuticals; manufacture, processing and production of recombinant proteins for use in the biotechnology industries to the order and specification of others; cell culture manufacturing services for others; custom manufacture of biologics; information, advice and consultancy in relation to all the aforesaid Construction services, namely, the building and installation of pharmaceutical and biopharmaceutical manufacturing facilities; building construction services; construction of pharmaceutical facilities; construction management services, namely, onsite management relating to the construction of pharmaceutical manufacturing facilities; building and construction of factories; custom construction of factories and pharmaceutical manufacturing facilities; information, advice and consultancy in relation to all the aforesaid Scientific and technological services, namely, scientific research, analysis and testing in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; research and development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; scientific analysis in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial and technical research, development and analysis services; scientific, industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use and manufacture of biotechnology products; technical project studies in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use in the manufacture of biotechnology products; biotechnology product testing services; research and consultancy in the field of biotechnology; research and development in the pharmaceutical and biotechnology industry; scientific, technological and pharmaceutical process development and design in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; biopharmaceutical product development; computer software development, programming and implementation for others; design and development of computer software; design and development of manufacturing processes in the field of biopharmaceuticals; design of manufacturing methods; design of industrial buildings; design of manufacturing plants; engineering services in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; medical and biological research laboratory services; preparation of biological samples for analysis in research laboratories; development of processes for use in the manufacture of products in the biotechnology industry; design services relating to manufacturing plants for the biotechnology industry; information, advice and consultancy in relation to all the aforesaid
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom processing and manufacturing of biopharmaceuticals; custom processing and manufacturing of pharmaceuticals; custom manufacture of pharmaceuticals; manufacture, processing and production of recombinant proteins for use in the biotechnology industries to the order and specification of others; cell culture manufacturing services for others; custom manufacture of biologics; information, advice and consultancy in relation to all the aforesaid Construction services, namely, the building and installation of pharmaceutical and biopharmaceutical manufacturing facilities; building construction services; construction of pharmaceutical facilities; construction management services, namely, onsite management relating to the construction of pharmaceutical manufacturing facilities; building and construction of factories; custom construction of factories and pharmaceutical manufacturing facilities; information, advice and consultancy in relation to all the aforesaid Scientific and technological services, namely, scientific research, analysis and testing in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; research and development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; scientific analysis in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial and technical research, development and analysis services; scientific, industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use and manufacture of biotechnology products; technical project studies in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use in the manufacture of biotechnology products; biotechnology product testing services; research and consultancy in the field of biotechnology; research and development in the pharmaceutical and biotechnology industry; scientific, technological and pharmaceutical process development and design in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; biopharmaceutical product development; computer software development, programming and implementation for others; design and development of computer software; design and development of manufacturing processes in the field of biopharmaceuticals; design of manufacturing methods; design of industrial buildings; design of manufacturing plants; engineering services in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; medical and biological research laboratory services; preparation of biological samples for analysis in research laboratories; development of processes for use in the manufacture of products in the biotechnology industry; design services relating to manufacturing plants for the biotechnology industry; information, advice and consultancy in relation to all the aforesaid
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom processing and manufacturing of biopharmaceuticals; custom processing and manufacturing of pharmaceuticals; custom manufacture of pharmaceuticals; manufacture, processing and production of recombinant proteins for use in the biotechnology industries to the order and specification of others; cell culture manufacturing services for others; custom manufacture of biologics; information, advice and consultancy in relation to all the aforesaid Scientific and technological services, namely, scientific research, analysis and testing in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; research and development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; scientific analysis in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial and technical research, development and analysis services; scientific, industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use and manufacture of biotechnology products; technical project studies in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; industrial process development in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; development of processes for the use in the manufacture of biotechnology products; biotechnology product testing services; research and consultancy in the field of biotechnology; research and development in the pharmaceutical and biotechnology industry; scientific, technological and pharmaceutical process development and design in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; biopharmaceutical product development; computer software development, programming and implementation for others; design and development of computer software; design and development of manufacturing processes in the field of biopharmaceuticals; design of manufacturing methods; design of industrial buildings; design of manufacturing plants; engineering services in the fields of biotechnology, biologics, biopharmaceuticals and pharmaceuticals; medical and biological research laboratory services; preparation of biological samples for analysis in research laboratories; development of processes for use in the manufacture of products in the biotechnology industry; design services relating to manufacturing plants for the biotechnology industry; information, advice and consultancy in relation to all the aforesaid
FUJIFILM SPECIALITY INK SYSTEMS LIMITED (Royaume‑Uni)
FUJIFILM IMAGING COLORANTS LIMITED (Royaume‑Uni)
Inventeur(s)
Coe, Iris
Royles, Brodyck
Swiecicka-Fichou, Joanna
Abrégé
The present invention relates to an inkjet ink comprising: a continuous aqueous phase; a dispersed encapsulated pigment consisting of pigment particles encapsulated by a cross-linked polymer coating having pendant hydrophilic groups including hydroxyl groups; and a cross-linking agent having two or more protected reactive groups, wherein the two or more protected reactive groups, when deprotected, are reactive to hydroxyl groups. The present invention also relates to a method of inkjet printing, a dispersion and a printed substrate.
C09D 11/326 - Encres à pigments caractérisées par le dispersant du pigment
C09D 11/107 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone à partir d'acides non saturés ou de leurs dérivés
FUJIFILM SPECIALITY INK SYSTEMS LIMITED (Royaume‑Uni)
FUJIFILM IMAGING COLORANTS LIMITED (Royaume‑Uni)
Inventeur(s)
Coe, Iris
Royles, Brodyck
Swiecicka-Fichou, Joanna
Abrégé
The present invention relates to an inkjet ink comprising: a continuous aqueous phase; a dispersed encapsulated pigment comprising pigment particles encapsulated by a cross-linked polymer coating having pendant hydrophilic groups including hydroxyl groups; and a cross-linking agent having two or more protected reactive groups, wherein the two or more protected reactive groups, when deprotected, are reactive to hydroxyl groups. The present invention also relates to a method of inkjet printing, a dispersion and a printed substrate.
C09D 11/326 - Encres à pigments caractérisées par le dispersant du pigment
C09D 11/107 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone à partir d'acides non saturés ou de leurs dérivés
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Mulvihill, Daniel
Baker, Karen
Eastwood, Tara
Lennon, Christopher
Abrégé
Described is a method and component parts of a recombinant expression system for the expression of a biological molecule. In particular, an isolated vesicle nucleating polypeptide (VNp) comprising an amphipathic alpha helix polypeptide derived from the amino terminus of synuclein isoforms and variants thereof is used to promote, enhance or increase the formation of vesicles in the expression system to enable purification of the biological molecule.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Haigh, Jonathan
Heise, Charles
Topping, Andrew
Pullen, James
Abrégé
A process for purifying a composition comprising water, a target substance, impurities and optionally cells, the process comprising the steps (A) and (B):
(A) preparing a liquid feedstock by performing step (Ai) and/or (Aii) on the composition:
(Ai) removing at least some of the cells from the composition;
(Aii) concentrating the composition by removing water therefrom; and
(B) passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified target substance and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v). The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
22.
Apparatus for Purifying a Liquid Comprising a Target Substance
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Haigh, Jonathan
Heise, Charles
Topping, Andrew
Pullen, James
Abrégé
Apparatus for purifying a liquid comprising a target substance comprising at least two units arranged in series such that the feed stream of the second and any subsequent units comprises the product stream from a downstream unit, wherein each unit comprises specified components (i) to (vi), including a a switchable bypass assembly. Also claimed are the units and a flowpath assembly. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
C07K 1/16 - ExtractionSéparationPurification par chromatographie
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Haigh, Jonathan
Heise, Charles
Topping, Andrew
Pullen, James
Abrégé
A process for purifying a liquid feedstock comprising a monoclonal antibody and impurities, the process comprising passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified monoclonal antibody and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v) which include a multiple inlet flow-controller comprising two or more variable flow inlet valves for in situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One of the units performs chromatography and another performs viral inactivation. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
C07K 16/06 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux provenant de sérum
B01D 15/14 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à l'introduction de l'alimentation dans l'appareil
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Saunders, Fay Louise
Dodds, Anna Louise
Bayard, Adeline Marie Geraldine
Kara, Bhupendra Vallabh
Abrégé
A process for the production of a target polypeptide is provided. The process comprises expression of an expression vector for expressing a target polypeptide in a host cell, preferably a mammalian cell, the expression vector comprising an expression cassette comprising a polynucleotide encoding a recombinant polypeptide operably linked to a fibronectin secretion leader sequence; and recovering the target polypeptide.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C07K 16/06 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux provenant de sérum
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
Medical apparatus for use in endoscopy; Endoscopy cameras for medical purposes; Optical instruments for medical endoscopy; Medical diagnostic apparatus for medical purposes; Medical analytical apparatus for medical purposes; Medical instruments; Medical imaging apparatus; Medical apparatus and devices; Electronic apparatus for medical purposes; Medical diagnostic instruments; Medical analysis instruments; Apparatus for use in medical analysis; Diagnostic instruments for medical use. Demonstration of goods; Presentation of goods and services; Demonstration of goods for promotional purposes; Demonstration of goods for advertising purposes; Presentation of goods on communications media, for retail purposes; Display services for merchandise; Arranging business introductions relating to the buying and selling of products; Demonstration of products; Advertising particularly services for the promotion of goods; Retail services in relation to medical apparatus; Wholesale services in relation to medical apparatus; Promoting and conducting trade shows; Organisation and conducting of product presentations; Planning and conducting of trade fairs, exhibitions and presentations for economic or advertising purposes.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Continuous production, including continuous manufacture and
purification, of biological products such as cells, viruses
and biomolecules, including genes and proteins, obtained
from recombinant cells, to the order and specification of
others; continuous expression, isolation and purification,
of biological products such as cells, viruses and
biomolecules, including genes and proteins, obtained from
recombinant cells, to the order and specification of others;
continuous connected upstream and downstream production of
biological products such as cells, viruses and biomolecules,
including genes and proteins, obtained from recombinant
cells, to the order and specification of others. Scientific, industrial and technical research, development
and analysis services related to continuous production,
including continuous manufacture and purification, of
biological products such as such as cells, viruses and
biomolecules, including genes and proteins, obtained from
recombinant cells; process development related to the
continuous production, including continuous manufacture and
purification, of biological products such as such as cells,
viruses and biomolecules, including genes and proteins,
obtained from recombinant cells; industrial design services
related to the continuous production, including continuous
manufacture and purification, of biological products such as
such as cells, viruses and biomolecules, including genes and
proteins, obtained from recombinant cells; provision of
facilities for scientific, industrial and technical research
development related to the continuous production, including
continuous manufacture and purification, of biological
products such as such as cells, viruses and biomolecules,
including genes and proteins, obtained from recombinant
cells.
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Abrégé
A static mixing apparatus for mixing a fluid, preferably a liquid is provided. The mixer comprises a plurality of chambers in series, the first chamber of the series comprising a fluid inlet, and the final chamber of the series comprising a fluid outlet, each chamber except the final chamber including orifices defining a flow path from the fluid inlet and into each chamber in series and to the fluid outlet and the final chamber including a gas outlet located at the opposite end of the static mixing apparatus to the fluid inlet and fluid outlet.
B01F 25/452 - Mélangeurs dans lesquels les composants du mélange sont pressés ensemble au travers d’orifices ou d’espaces interstitiels, p. ex. entre des perles caractérisés par des éléments pourvus d'orifices ou d'espaces interstitiels
B01F 25/00 - Mélangeurs à écoulementMélangeurs pour matières tombantes, p. ex. particules solides
B01F 25/435 - Tubes de mélange composés d'éléments tubulaires concentriques
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Nagy, Tibor
Abrégé
A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.
A composite ion exchange membrane comprising components (a) and (b): (a) a membrane layer comprising ionic groups, two opposing surfaces and optionally a porous support; (b) a layer comprising sulpho groupsbound to at least one of the at least two opposing surfacesof the membrane layer (a); wherein the layer comprising sulpho groupshas a thickness of less than 100nm and the composite ion exchange membranehasa surface zeta potential of 0 to -7.5mV.
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 69/10 - Membranes sur supportSupports pour membranes
B01D 71/40 - Polymères d'acides non saturés ou de leurs dérivés, p. ex. sels, amides, imides, nitriles, anhydrides, esters
B01D 71/82 - Matériaux macromoléculaires non prévus spécifiquement dans un seul des groupes caractérisés par la présence de groupes déterminés, p. ex. introduits par un post-traitement chimique
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Haigh, Jonathan
Heise, Charles
Topping, Andrew
Pullen, James
Abrégé
in situin situ production of a bioprocessing liquid by combining at least two liquids in a desired ratio. One of the units performs chromatography and another performs viral inactivation. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
G01N 30/34 - Contrôle des paramètres physiques du fluide vecteur de la composition du fluide, p. ex. du gradient
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale
C07K 1/16 - ExtractionSéparationPurification par chromatographie
C07K 1/36 - ExtractionSéparationPurification par une combinaison de plusieurs procédés de types différents
C12N 7/04 - Inactivation ou atténuationProduction de parties élémentaires de virus
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Haigh, Jonathan
Heise, Charles
Topping, Andrew
Pullen, James
Abrégé
A process for purifying a composition comprising water, a target substance, impurities and optionally cells, the process comprising the steps (A) and (B): (A) preparing a liquid feedstock by performing step (Ai) and/or (Aii) on the composition: (Ai) removing at least some of the cells from the composition; (Aii) concentrating the composition by removing water therefrom; and (B) passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a product stream containing purified target substance and optionally a waste stream comprising at least some of the impurities, wherein each unit comprises specified components (i) to (v). The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
C07K 1/36 - ExtractionSéparationPurification par une combinaison de plusieurs procédés de types différents
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
G01N 30/34 - Contrôle des paramètres physiques du fluide vecteur de la composition du fluide, p. ex. du gradient
G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
34.
APPARATUS FOR PURIFYING A LIQUID COMPRISING A TARGET SUBSTANCE
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Haigh, Jonathan
Heise, Charles
Topping, Andrew
Pullen, James
Abrégé
Apparatus for purifying a liquid comprising a target substance comprising at least two units arranged in series such that the feed stream of the second and any subsequent units comprises the product stream from a downstream unit, wherein each unit comprises specified components (i) to (vi), including a a switchable bypass assembly. Also claimed are the units and a flowpath assembly. The units may be essentially the same except for a device they contain, leading to advantages in terms of simplicity, cost and ease of operation, lower risk of operator error, easier maintenance and lower inventory of spare parts.
G01N 30/34 - Contrôle des paramètres physiques du fluide vecteur de la composition du fluide, p. ex. du gradient
G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
C07K 1/36 - ExtractionSéparationPurification par une combinaison de plusieurs procédés de types différents
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
35.
Apparatus for processing a liquid comprising a target substance
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Haigh, Jonathan
Nagy, Tibor
Pullen, James
Topping, Andrew
Abrégé
Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided. The apparatus comprises at least a first and a second means for carrying out a unit operation, each means for carrying out a unit operation comprising a feed for a liquid in fluid connection with the inlet of a flow-controller comprising a variable flow inlet valve and an outlet, wherein at least one of the means for carrying out a unit operation comprises feeds for at least two liquids, the feeds being in fluid connection with the inlets of a multiple inlet flow-controller comprising two or more variable flow inlet valves for dosing the at least two liquids, the flow-controller also comprising an outlet; a feed for a liquid feedstock comprising the target substance in fluid connection with the outlet from the flow-controller thereby to enable combination of the feed for a liquid comprising the target substance with the mixed bioprocessing liquids to produce a device feed; a device for achieving a processing operation comprising a device inlet and a device outlet, the device inlet being in fluid connection with the device feed; and a means for imparting flow through the flow controller and from the feed for the liquid feedstock through the processing device via the device inlet; and wherein the feed for a liquid feedstock comprising the target substance for the second means for carrying out a unit operation comprises the outlet from the first means for carrying out a unit operation.
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Apparatus for use in separation and purification, including
separation and purification of biological products such as
cells, viruses and biomolecules, including genes and
proteins; liquid chromatography apparatus for laboratory or
scientific use; ion exchange apparatus for laboratory or
scientific use; ultrafiltration apparatus for laboratory or
scientific use; diafiltration apparatus for laboratory or
scientific use; apparatus for diluting or concentrating
biological products for laboratory or scientific use;
apparatus for removal of viruses from solutions, including
biological products, for laboratory or scientific use;
apparatus for inactivation of viruses from solutions for
laboratory or scientific use; apparatus for membrane
filtration for laboratory or scientific use; apparatus for
performing chromatographic separations and parts thereof for
laboratory or scientific use; flowpaths, parts and fittings,
including tubing, valves, in-line mixers, pressure sensors,
temperature sensors and/or other sensors for all the
aforesaid goods; computer software for control of the
aforesaid goods; computer software for management of
biological product purification processes. Apparatus for use in separation and purification for
industrial purposes, including separation and purification
of biological products such as cells, viruses and
biomolecules, including genes and proteins; liquid
chromatography apparatus for industrial purposes; ion
exchange apparatus for industrial purposes; ultrafiltration
apparatus for industrial purposes; diafiltration apparatus
for industrial purposes; apparatus for diluting or
concentrating biological products for industrial purposes;
apparatus for removal of viruses from solutions, including
biological products for industrial purposes; apparatus for
inactivation of viruses from solutions for industrial
purposes; apparatus for membrane filtration for industrial
purposes; apparatus for performing chromatographic
separations and parts thereof for industrial purposes;
flowpaths, parts and fittings, including tubing, valves,
in-line mixers, pressure sensors, temperature sensors and/or
other sensors for all the aforesaid goods. Processing and manufacturing of biological products such as
cells, viruses and biomolecules, including genes and
proteins, including to the order and specification of
others; manufacture, processing and production of
biomolecules such as cells, viruses and biomolecules,
including genes and proteins, to the order and specification
of others. Scientific, industrial and technical research, development
and analysis services related to biological products such as
such as cells, viruses and biomolecules, including genes and
proteins; process development related to the manufacture and
purification of biological products such as such as cells,
viruses and biomolecules, including genes and proteins;
industrial design services related to the manufacture and
purification of biological products such as such as cells,
viruses and biomolecules, including genes and proteins;
provision of facilities for scientific, industrial and
technical research development related to the manufacture
and purification of biological products such as such as
cells, viruses and biomolecules, including genes and
proteins.
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Lennon, Christopher
Abrégé
A protein expression system for use in a prokaryotic host is provided, the expression system comprising: a) an expression cassette comprising a nucleic acid sequence encoding a protein of interest operably linked to a T7 RNA polymerase-dependent promoter; and b) an expression cassette comprising a nucleic acid sequence encoding T7 RNA polymerase operably linked to a host polymerase-dependent λ phage promoter and a single perfect palindrome operator sequence; wherein the expression cassette for T7 RNA polymerase is located on the chromosome of a host cell.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Continuous, custom production or manufacture, namely continuous extraction, and purification, of biological products in the nature of cells, viruses and biomolecules, genes and proteins, obtained from recombinant cells, to the order and specification of others; Continuous, custom manufacture, namely continuous expression isolation, and purification, of biological products in the nature of cells, viruses and biomolecules, genes and proteins, obtained from recombinant cells, to the order and specification of others; Continuous, custom production or manufacture, namely, continuous connected upstream and downstream manufacture of biological products in the nature of cells, viruses and biomolecules, genes and proteins, obtained from recombinant cells, to the order and specification of others Scientific, industrial and technical research, development and analysis services related to continuous production, continuous manufacture and purification, of biological products in the nature of cells, viruses and biomolecules, genes and proteins, obtained from recombinant cells; Scientific research and development, namely process development related to the continuous production, continuous manufacture and purification, of biological products in the nature of cells, viruses and biomolecules, genes and proteins, obtained from recombinant cells; Industrial design services related to the continuous production, continuous manufacture and purification, of biological in the nature of cells, viruses and biomolecules, genes and proteins, obtained from recombinant cells; Provision of facilities for scientific, industrial and technical research development related to the continuous production, continuous manufacture and purification, of biological products in the nature of cells, viruses and biomolecules, genes and proteins, obtained from recombinant cells
39.
MEMBRANES AND PROCESSES FOR THEIR PREPARATION AND USE
A membrane comprising polymer particles fused together and pores between the fused particles, wherein: (a) the polymer particles have an average diameter of 0.1 to 5,000nm; (b) the membrane having a mean flow pore size of 5nm to 5,000nm; and (c) the membrane has been obtained by a process comprising curing a composition comprising: (i) a monomer; (ii) an organic polymerisation retardant; and (iii) an inert solvent; 0.149. The membranes are useful for detecting metal ions and for filtering and/or purifying biomoleculesand compositions comprising metal-ions.
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Nagy, Tibor
Abrégé
Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means for mixing at least two liquids comprising a multiple inlet flow-controller, the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device configured in single-pass mode.
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Abrégé
A method for preparing an aqueous solution of a defined pH comprising an acid, a base and optionally one or more additives is provided. The method comprises the steps of:
a) calculating the theoretical concentrations of acid and base for the solution to have the defined pH using the Henderson-Hasselbach equation in combination with the Debye Huckel theory for a range of different additive concentrations; b) preparing a sample of the buffer for the range of additive concentrations and measuring the actual pH for each additive concentration; c) calculating a value for delta pH, ΔpH, being the difference between the theoretical pH and the actual pH, for each additive concentration; d) generating a mathematical model describing the relationship of ΔpH with additive concentration; e) selecting the defined pH and additive concentrations; f) using the mathematical model generated in step d) to calculate ΔpH for the defined pH and additive concentration; g) calculating a ΔpH-corrected pH by summing the defined pH and delta pH; h) using the ΔpH-corrected pH to calculate the concentrations of acid and base using the Henderson-Hasselbach equation in combination with the Debye Huckel theory; i) preparing the solution using the concentrations calculated in step h).
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
G01N 30/34 - Contrôle des paramètres physiques du fluide vecteur de la composition du fluide, p. ex. du gradient
G05D 21/02 - Commande des variables chimiques ou physico-chimiques, p. ex. de la valeur du pH caractérisée par l'utilisation de moyens électriques
B01F 25/42 - Mélangeurs statiques dans lesquels le mélange est affecté par le déplacement conjoint des composants dans des directions différentes, p. ex. dans des tubes munis de chicanes ou d'obstructions
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
09 - Appareils et instruments scientifiques et électriques
11 - Appareils de contrôle de l'environnement
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Fluid processing system for use in the separation and purification of biological products such as cells, viruses and biomolecules, including nucleic acids and proteins, for bioprocessing and pharmaceutical research, comprised primarily of chromatography apparatus for laboratory use, laboratory filters, and fluid handling devices used for bioprocessing applications and component parts and fittings; Liquid chromatography apparatus for laboratory use; Ion exchange chromatography apparatus for the treatment of fluids for laboratory use; Ultrafiltration apparatus for laboratory or scientific research use, namely, ultrafiltration laboratory filters and laboratory ultrafiltration filter membranes as part of scientific apparatus; Diafiltration apparatus for laboratory or scientific research use, namely, laboratory diafiltration filters; Scientific, laboratory, and measuring apparatus and instruments for diluting or concentrating biological products for laboratory or scientific research use, namely, tangential flow filtration devices for preparation of biological samples for use in the biopharmaceutical industry; Laboratory filters in the nature of viral filtration apparatus for removal of viruses from solutions for laboratory or scientific research use; Membrane filtration apparatus in the nature of membrane laboratory filters for use in laboratory equipment in the biopharmaceutical industry for treating biological fluids and solutions; Chromatography apparatus and component parts thereof for laboratory or scientific research use; Parts and fittings, namely, tubing, valves, in-line mixers, pressure sensors, temperature sensors and electronic sensors specially adapted for use with all of the aforementioned goods; Computer software for control of the aforesaid goods, namely, downloadable and recorded software for operating a fluid processing apparatus for laboratory or scientific research use comprising chromatography, membrane filtration, tangential flow filtration, viral filtration, ultrafiltration, diafiltration, viral filtration, viral inactivation, in-line conditioning, and buffer management components and systems; Computer software for management of biological product purification processes, namely, downloadable and recorded software for managing the purification of cells, viruses, and biomolecules in the nature of nucleic acids and proteins Fluid processing system apparatus and system for use in the separation and purification of biological products such as cells, viruses and biomolecules, including nucleic acids and proteins, for the pharmaceutical and biomanufacturing industries, namely, chromatography apparatus for industrial use and apparatus and instruments for use in the purification, conditioning, separation and sterilization of liquids and gases used in the biotechnology, pharmaceutical, medical, and biopharmaceutical industries; Liquid chromatography apparatus for industrial purposes; Ion exchange apparatus for the treatment of fluids for industrial purposes; Ultrafiltration apparatus for industrial purposes, namely, apparatus and instruments for use in the purification, separation and sterilization of liquids and gases used in the biotechnology, pharmaceutical, medical, and biopharmaceutical industries; Diafiltration apparatus, namely, aqueous solution filtering systems and components and biological fluid filtering systems and components for industrial purposes being apparatus and instruments for use in the purification, separation and sterilization of liquids used in the biotechnology, pharmaceutical, medical, and biopharmaceutical industries; Apparatus for diluting or concentrating biological products for industrial purposes, namely, tangential flow filtration apparatus being apparatus for use in the purification, separation and sterilization of liquids and gases used in the biotechnology, pharmaceutical, medical, and biopharmaceutical industries; Viral filtration apparatus for removal of viruses from solutions for industrial purposes, namely, apparatus and instruments for use in the purification, separation and sterilization of liquids and gases used in the biotechnology, pharmaceutical, medical, and biopharmaceutical industries; Virus inactivation and disinfection apparatus for the treatment of biological products in the field of biomanufacturing and pharmaceuticals, all for industrial purposes in the nature of apparatus and instruments for use in the purification, separation and sterilization of liquids and gases used in the biotechnology, pharmaceutical, medical, and biopharmaceutical industries; Membrane filtration apparatus for industrial purposes in the nature of membrane filter cartridges for the separation of biomolecules in biopharmaceutical production; Chromatography apparatus for industrial purposes and component parts thereof; Parts and fittings, namely, tubing, valves, in-line mixers, pressure sensors, temperature sensors and electric sensors, specially adapted for use with the aforementioned Processing and manufacturing of biological products such as cells, viruses and biomolecules, including genes and proteins, namely, manufacturing of pharmaceuticals using biological organisms in the manufacturing process to the order and specification of others; Manufacture of biomolecules such as cells, viruses and biomolecules, including genes and proteins, to the order and specification of others Scientific research, industrial biomedical research and technical product research and development services in the field of biomanufacturing, bioprocessing and pharmaceuticals related to biological products such as cells, viruses and biomolecules, including nucleic acids and proteins; Process development services related to the manufacture and purification of biological products such as such as cells, viruses and biomolecules, including nucleic acids and proteins, namely, biomedical and pharmaceutical research; Industrial design services related to the manufacture and purification of biological products such as cells, viruses and biomolecules, including nucleic acids and proteins; Provision of facilities for scientific, industrial and technical research and development in the field of biomanufacturing, bioprocessing and pharmaceuticals, namely, scientific laboratory services
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Abrégé
A static mixing apparatus for mixing a fluid, preferably a liquid is provided. The mixer comprises a plurality of chambers (5, 8, 12, 15) in series, the first chamber (5) of the series comprising a fluid inlet (4), and the final chamber (15) of the series comprising a fluid outlet (16), each chamber other than the final chamber in the series being in fluid connection with a subsequent chamber, the fluid connection comprising a plurality of orifices (7, 10, 11, 14) dispersed along a direction of flow, the nearest point to the fluid inlet of each subsequent orifice to the inlet overlapping with the furthest point from the fluid inlet of the previous orifice, and being off-set along the direction of flow from the previous orifice.
Membranes having an average pore size of 5 nm to 5,000 nm and a porosity of 15% or more, said membrane being obtainable by a process comprising curing a composition comprising: to 64 wt% of (i) a cross-linking agent comprising at least one cationic group; and 36 to 95wt% of (ii) inert solvent(s). The membranes are useful for detecting, filtering and/or purifying biomolecules.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 15/34 - Séparation par sélection en fonction de la taille, p. ex. chromatographie d'exclusion de tailleFiltration sur gelPerméation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
Membranes having an average pore size of 5 nm to 5,000 nm and a porosity of 10% or more, said membrane being obtainable by a process comprising curing a composition comprising: (i) a cross-linking agent comprising at least one anionic group; and (ii) inert solvent(s). The membranes are useful for detecting metal ions and for filtering and/or purifying biomolecules and compositions comprising metal-ions.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 15/34 - Séparation par sélection en fonction de la taille, p. ex. chromatographie d'exclusion de tailleFiltration sur gelPerméation
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Haigh, Jonathan
Nagy, Tibor
Pullen, James
Topping, Andrew
Abrégé
Apparatus for processing a liquid comprising a target substance, preferably a biomolecule, is provided. The apparatus comprises at least a first and a second means for carrying out a unit operation, each means for carrying out a unit operation comprising a feed for a liquid in fluid connection with the inlet of a flow-controller comprising a variable flow inlet valve and an outlet, wherein at least one of the means for carrying out a unit operation comprises feeds for at least two liquids, the feeds being in fluid connection with the inlets of a multiple inlet flow-controller comprising two or more variable flow inlet valves for dosing the at least two liquids, the flow-controller also comprising an outlet; a feed for a liquid feedstock comprising the target substance in fluid connection with the outlet from the flow-controller thereby to enable combination of the feed for a liquid comprising the target substance with the mixed bioprocessing liquids to produce a device feed; a device for achieving a processing operation comprising a device inlet and a device outlet, the device inlet being in fluid connection with the device feed; and a means for imparting flow through the flow controller and from the feed for the liquid feedstock through the processing device via the device inlet; and wherein the feed for a liquid feedstock comprising the target substance for the second means for carrying out a unit operation comprises the outlet from the first means for carrying out a unit operation.
A composite membrane comprising (a) a porous support; (b)optionally a gutter layer; (c) a discriminating layer comprising (i) 1 to 99wt% of a polyimide comprising a repeat unit of Formula (1); and (ii) 1 to 99wt% in total of a polyimide comprising a repeat unit of Formula (2) and/or a polymer comprising more than one pendant acrylate group; and (d) optionally a protective layer; wherein L and A are each independently a divalent organic linking group; R1and R2in Formula (2) are each independently H or an alkyl group; and R is a tetravalent linking group other than a group of Formula (I-24) wherein R1and R2in Formula (I-24)are identical to the R1and R2 groups in Formula (2).
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Nagy, Tibor
Abrégé
A method for preparing an aqueous solution of a defined pH comprising an acid, a base and optionally one or more additives is provided. The method comprises the steps of: a) calculating the theoretical concentrations of acid and base for the solution to have the defined pH using the Henderson-Hasselbach equation in combination with the Debye Huckel theory for a range of different additive concentrations; b) preparing a sample of the buffer for the range of additive concentrations and measuring the actual pH for each additive concentration; c) calculating a value for delta pH, ∆pH, being the difference between the theoretical pH and the actual pH, for each additive concentration; d) generating a mathematical model describing the relationship of ∆pH with additive concentration; e) selecting the defined pH and additive concentrations;f) using the mathematical model generated in step d) to calculate ∆pH for the defined pH and additive concentration; g) calculating a ∆pH-corrected pH by summing the defined pH and delta pH; h) using the ∆pH-corrected pH to calculate the concentrations of acid and base using the Henderson-Hasselbach equation in combination with the Debye Huckel theory; i) preparing the solution using the concentrations calculated in step h).
G01N 30/34 - Contrôle des paramètres physiques du fluide vecteur de la composition du fluide, p. ex. du gradient
G05D 21/02 - Commande des variables chimiques ou physico-chimiques, p. ex. de la valeur du pH caractérisée par l'utilisation de moyens électriques
B01J 47/15 - Commande ou régulation pour l’obtention d’une solution ayant un pH fixe
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
49.
SPIRAL WOUND MEMBRANE MODULE FOR GAS SEPARATION WITH PROTECTION LAYER
A process for separating a feed gas comprising a polar gas and a non-polar gas into a permeate gas and a retentate gas, one of which is enriched in the polar gas and the other of which is depleted in the polar gas, the process comprising passing the feed gas through a gas separation module comprising: (i) a feed carrier comprising a membrane envelope and a feed spacer located within the membrane envelope; and (ii) a permeate carrier comprising: (a) a macroporous sheet; and (b) a protective sheet; and wherein: i) the feed gas is fed along the feed spacer of the feed carrier and a part of the feed gas passes through the membrane envelope and into the permeate carrier to give the permeate gas and a part of the feed gas is rejected by the membrane to give the retentate gas; ii) the protective sheet shields at least a part of the membrane envelope from contact with the macroporous sheet; and iii) the protective sheet comprises a non-woven material.
B01D 63/10 - Modules à membranes enroulées en spirale
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 69/10 - Membranes sur supportSupports pour membranes
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Nagy, Tibor
Abrégé
A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow-controller, such as a valve.
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Nagy, Tibor
Abrégé
Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.
A method for generating electricity comprising the steps: (A) passing a concentrated ionic solution through a first pathway in a reverse electrodialysis unit comprising a membrane stack having electrodes and alternating cation and anion exchange membranes; and (B) passing a dilute ionic solution through a second pathway in said reverse electrodialysis unit, whereby solute from the concentrated solution in the first pathway passes through the membranes to the dilute solution in the second pathway, thereby generating electricity; wherein: (i) the concentrated ionic solution and the dilute ionic solution each comprise a main salt; and (ii) the main salt present in each of the concentrated ionic solution and the dilute ionic solution as they enter the reverse electrodialysis unit is such that Equation 1 is satisfied: ACc/ACd is at least 1.5 (Equation 1) wherein ACc and ACd are the activity coefficients of the main salts present in the concentrated and dilute ionic solutions when measured at a concentration of 6 mol/kg water at 25°C and at a concentration of 0.5 mol/kg water at 25°C respectively.
H01M 8/22 - Éléments à combustible dans lesquels le combustible est à base de matériaux comprenant du carbone, de l'oxygène ou de l'hydrogène et d'autres élémentsÉléments à combustible dans lesquels le combustible est à base de matériaux comprenant uniquement des éléments autres que le carbone, l'oxygène ou l'hydrogène
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cell cultures used in industry and science; mammalian cell
cultures and vectors, being independent replicating pieces
of DNA that can transfer DNA sequences, each for manufacture
and development in the biotechnology industries. Processing and manufacturing of vectors, cell cultures and
recombinant proteins for use in biotechnology industries to
the order and specification of others; manufacture,
processing and production of recombinant proteins for use in
the biotechnology industries to the order and specification
of others. Scientific, industrial and technical research, development
and analysis services relating to the use of mammalian cell
cultures and vectors in the field of biotechnology; process
development, namely, development of processes for the use of
mammalian cell cultures and vectors in the manufacture of
biotechnology products; project studies relating to the use
of mammalian cell cultures and vectors in the field of
biotechnology.
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Lennon, Christopher
Abrégé
A protein expression system for use in a prokaryotic host is provided, the expression system comprising: a) an expression cassette comprising a nucleic acid sequence encoding a protein of interest operably linked to a T7 RNA polymerase-dependent promoter; and b) an expression cassette comprising a nucleic acid sequence encoding T7 RNA polymerase operably linked to a host polymerase-dependent λ phage promoter and a single perfect palindrome operator sequence; wherein the expression cassette for T7 RNA polymerase is located on the chromosome of a host cell.
A process for preparing a membrane comprising applying a composition comprising a polyimide to a gas-permeable support and irradiating the composition with UV-C light source to form a discriminating layer on the support, wherein: (i) the UV-C light source emits light having a wavelength in the range 200 to 280nm; (ii) the irradiation is performed for a period of time in the range 0.05 to 60 seconds; and (iii) the irradiation is performed at a power intensity of at least 20 mW/cm2 and no more than 250 mW/cm2
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 69/10 - Membranes sur supportSupports pour membranes
B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide-acides ou précurseurs similaires de polyimides
A hydrogel comprising: water; an alginate; a glucono-delta-lactone (GDL); and micropartides comprising an inorganic calcium compound and recombinant gelatin. The hydrogels may be used for bone repair and/or regeneration.
A composite membrane comprising: (a) a porous support; (b) optionally a gutter layer; (c) a polyimide discriminating layer; and (d) a protective layer comprising dialkylsiloxane groups and having an average thickness of 825 to 2,000 nm; wherein the polyimide discriminating layer comprises 2,4,6-trimethyl-1,3-phenylene groups, each such group independently having an atom or substituent other than H at the 5-position.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
B01D 69/10 - Membranes sur supportSupports pour membranes
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Saunders, Fay Louise
Dodds, Anna Louise
Bayard, Adeline Marie Geraldine
Kara, Bhupendra Vallabh
Abrégé
A process for the production of a target polypeptide is provided. The process comprises expression of an expression vector for expressing a target polypeptide in a host cell, preferably a mammalian cell, the expression vector comprising an expression cassette comprising a polynucleotide encoding a recombinant polypeptide operably linked to a fibronectin secretion leader sequence; and recovering the target polypeptide.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C07K 16/06 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux provenant de sérum
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
An aqueous ink comprising: from 0.1 to 8 parts by weight of a self-dispersible pigment which comprises a carboxy-functional dispersant crosslinked around a pigment core by a crosslinking agent having at least two groups selected from oxetane, carbodiimide, hydrazide, oxazoline, aziridine, isocyanate, N-methylol, keteneimine, isocyanurate and epoxy groups; from 10 to 25 parts by weight of a first solvent selected from one or more of the group consisting of ethylene glycol, propylene glycol, dipropylene glycol and triethylene glycol; from 2 to 10 parts by weight of a second solvent selected from one or more of the group consisting of 2-pyrrolidone, N-methyl-2-pyrrolidone, N-ethyl-2- pyrrolidone, N-cyclohexyl-2-pyrrolidone and N,N-dimethylacetamide; from 20 to 45 parts by weight of glycerol; from 4 to 12 parts by weight of a styrene butadiene latex binder and/or a polyurethane latex binder; from 0.1 to 2 parts by weight of an acetylenic surfactant; from 0 to 2 parts by weight of 1,2-benzisothiazolin-3-one; and the balance to 100 parts by weight water. Also ink-jet printing processes, printed materials, ink containers and ink-sets.
C09D 11/102 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
C09D 11/106 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
C09D 11/38 - Encres pour l'impression à jet d'encre caractérisées par des additifs non macromoléculaires autres que les solvants, les pigments ou les colorants
C09D 11/40 - Jeux d’encres spécialement adaptés à l’impression à jet d’encre à plusieurs couleurs
Self-adhesive boards of foam for mounting pictures,
self-adhesive wall decorations, adhesive wall decorations,
adhesive plastic film used for mounting images, adhesive
corners for photographs, adhesive corners for photographs,
paper picture mounts, photo albums and collectors' albums,
mounting photographs (apparatus for -); photograph holders. Fastening materials, not of metal (terms considered too
vague by the International Bureau - rule 13.2.b) of the
Common Regulations), decorations of foam (terms considered
too vague by the International Bureau - rule 13.2.b) of the
Common Regulations), photograph and picture frames.
A process for preparing a composite membrane comprising the steps: a) applying a radiation-curable composition to a porous support; b) irradiating the composition present on the support, thereby forming a gutter layer of cured polymer; c) forming a discriminating layer on the gutter layer; and d) applying a radiation-curable composition to the discriminating layer and irradiating that composition, thereby forming a protective layer on the discriminating layer; wherein one or both of the radiation-curable compositions applied in steps a) and d) comprise a photo acid generator having an absorbency coefficient ε at 313 nm of more than 1x104 mol-1*cm-1. Also claimed are composite membranes and gas separation cartridges comprising the membranes.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 69/10 - Membranes sur supportSupports pour membranes
Membrane cell stack arrangement comprising a housing, a stack of membranes defining flow compartments and a fluid manifold system, wherein the direction of flow through the flow compartments is different to the direction of flow through entry and exit openings and the width of the entry and exit openings are each larger than 45% of the width of the flow compartment.
An electrode unit comprising: (a)an electrically non-conductive circumferential housing; (b)a current collector; (c)an electrode; (d)optionally a charge barrier;and (e)an electrically conductive connector in electrical contact with the current collector(b); wherein(b), (c) and (d) (when present) are located within the circumference of the circumferential housing (a); the main plane of the part of (e) which is located within the housing (a) is substantially parallel to the main plane of (b), (e)extends beyond the housing (a),the electrode unit further comprises a barrier which prevents fluid passing through a device comprising the electrode unit from coming into contact with the connector (e). Also claimed are stacks, composites devices and their uses.
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
An electrode unit comprising: (a) an electrically non-conductive circumferential housing; (b) a current collector; (c) an electrode; (d) optionally a charge barrier; and (e) an electrically conductive connector in electrical contact with the current collector (b); wherein (b), (c) and (d) (when present) are located within the circumference of the circumferential housing (a); the main plane of the part of (e) which is located within the housing (a) is substantially parallel to the main plane of (b), (e) extends beyond the housing (a); and the area of the part of (e) which is located within the housing (a) is less than 30% of the area of (b). Also claimed are stacks, composites devices and their uses.
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Kara, Bhupendra Vallabh
Lennon, Christopher David John
Hodgson, Ian John
Abrégé
A perfect palindrome operator sequence-based protein expression system is provided. The expression system comprises a promoter; and a perfect palindrome operator sequence, wherein the promoter is not T7. The expression system is preferably employed for the production of recombinant proteins by fermentation.
C12N 15/78 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes procaryotes autres que E. coli, p. ex. Lactobacillus, Micromonospora pour Pseudomonas
C12N 15/81 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour champignons pour levures
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A membrane stack comprising the following components: (a) a first ion diluting compartment (D1); (b) a second ion diluting compartment (D2); (c) a first ion concentrating compartment (C1); (d) a second ion concentrating compartment (C2); and (e) a membrane wall (CEM1, mAEM, mCEM, AEM, CEM2) between each compartment and on the outside of the first and last compartment of the stack; wherein: (i) each membrane wall comprises a cation exchange membrane (CEM1, mCEM, CEM2) or an anion exchange membrane (mAEM, AEM) and the order of the cation and anion exchange membranes alternates from each wall to the next; (ii) the membrane walls (mAEM, mCEM) on each side of compartment (a) both have a higher monovalent ion selectivity than the corresponding membrane walls (AEM, CEM2) on each side of compartment (b); and (iii) the stack further comprises a means for communicating fluid between compartments (a) and (b).
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
C02F 1/46 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Nagy, Tibor
Abrégé
A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the liquid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pressure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow- controller, such as a valve.
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Heise, Charles
Nagy, Tibor
Abrégé
Apparatus for in-line liquid exchanging a biomolecule-containing liquid is provided. The apparatus comprises a means (3) for mixing at least two liquids comprising a multiple inlet flow-controller (2), the means for mixing also comprising an outlet in fluid connection with a tangential flow filtration device (1) configured in single-pass mode.
Membrane cell stack arrangement and method of manufacturing such a membrane cell stack arrangement. The arrangement has a housing (2) having a central axis, and a stack of membrane cells (4), each membrane cell (6) being arranged inside the housing (2) with a major surface (6a) of the membrane cell (6) oriented substantially perpendicular to the central axis. Each membrane cell (6) has a corner recess (12) between each two adjacent sides of at least four sides (10a-d). Sealing compartments (14) are provided by corner recesses (12) of adjacent membrane cells of the stack of membrane cells (4) in co-operation with a part of an inner surface (2a) of the housing (2).
B01D 65/00 - Accessoires ou opérations auxiliaires, en général, pour les procédés ou les appareils de séparation utilisant des membranes semi-perméables
A gas-separation module comprising: a) a permeate collection tube comprising a hollow cylinder provided with perforations oriented along the longitudinal axis of the cylinder; and b) at least seven membrane envelopes wound spirally around the permeate collection tube; wherein: (i) the membrane envelopes each comprise a feed spacer and gas- separation membrane(s), wherein the feed spacer is disposed between the gas-separation membrane(s) to define a feed channel and wherein the feed spacer comprises a polymer having a Tg above 0°C; (ii) the module comprises a permeate channel between each of the membrane envelopes in gas-communication with the perforations; and (iii) the permeate collection tube and the membrane envelopes are disposed such that when the module is in use, feed gas entering the feed channel can pass through the perforations only after passing through the gas- separation membranes from the feed channel to the permeate channel. Also claimed are gas separation units and a process for separating gases.
A process for printing on a textile substrate comprising the steps of: (I) preparing an ink comprising the following components: (a) from 1 to 8 parts of a self-dispersible pigment which comprises a carboxy-functional dispersant crosslinked around a pigment core by a crosslinking agent having at least two groups selected from oxetane, carbodiimide, hydrazide, oxazoline, aziridine, isocyanate, N-methylol, keteneimine, isocyanurate and epoxy groups; (b) from 0 to 16 parts of a binder selected from one or more of an acrylic latex binder, a styrene acrylic latex binder and a styrene butadiene latex binder wherein the binder has a Tg in the range of from -25°C to 35°C; (c) from 1 to 30 parts of one or more water-miscible organic solvents (d) from 0.1 to 3 parts of a surfactant; (e) from 0 to 5 parts of biocide; (f) from 0 to 10 parts of a viscosity modifier; (g) from 0 to 10 parts of a polyurethane latex binder with a Tg in the range of from -25°C to 35°C; (h) from 0 to 6 parts of a cross linking agent; and (i) the balance to 100 parts water: (II) optionally preparing a latex binders solution comprising; i) from 1 to 16 parts of one or more latex binders selected from an acrylic latex binder, a styrene acrylic latex binder and a styrene butadiene latex binder where the latex binder(s) have a Tg in the range of from -25°C to 35°C; ii) from 0 to 6 parts of a polyurethane latex binder; and iii) from 0 to 5 parts of a cross linking agent: (III) printing the ink prepared in step (I) on to a textile substrate using a ink jet printer with a single pass print head and optionally pre-printing or overprinting with the latex binder solution from step (II) (IV) curing the printed textile substrate from step (III): provided that if component (b) in the ink prepared in step (a) is 0 then optional step (II) is compulsory. Also inks, ink-sets, ink containers and ink-jet printers.
C09D 11/106 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
Self-adhesive boards of foam for mounting pictures, self-adhesive wall decorations, Adhesive wall decorations, Adhesive plastic film used for mounting images, Adhesive corners for photographs, Adhesive corners for photographs, Paper picture mounts, Photo albums and collectors' albums, Mounting photographs (Apparatus for -). Fastening materials, not of metal, photograph holders, decorations of foam, photograph and picture frames.
73.
RADIATION-CURABLE COMPOSITIONS, MEMBRANES AND THE MANUFACTURE AND USE OF SUCH MEMBRANES
A radiation-curable composition comprising: a)10 to 65 wt% of curable ionic compound(s) comprising one ethylenically unsaturated group; b)3 to 60 wt% of crosslinking agent(s) comprising at least two ethylenically unsaturated groups and having a number average molecular weight below 800; c)5 to 55 wt% of inert solvent(s) having a boiling point above 100°C; d)0 to 10 wt% of free-radical initiator(s); and e)0.5 to 25wt% of thickening agent(s).
A process for preparing an encapsulated pigment dispersion suitable for use in an ink jet printing ink comprising the following steps in the order I) followed by II): I)providing a dispersion comprising a pigment, a liquid medium and a dispersant having a WAMW of up to 50,000 Daltons obtained by copolymerising a monomer composition comprising components a) and b): a) from 75 to 97 parts of one or more hydrophobic ethylenically unsaturated monomers comprising at least 50 parts benzyl (meth) acrylate; and b) from 3 to 25 parts one or more hydrophilic ethylenically unsaturated monomers having one or more ionic group(s); wherein the parts are by weight and the sum of the parts a) and b) add up to 100; II) cross-linking the dispersant in the presence of the pigment and the liquid medium.
C09D 11/107 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone à partir d'acides non saturés ou de leurs dérivés
B01F 17/00 - Utilisation de substances comme agents émulsifiants, humidifiants, dispersants ou générateurs de mousse
C09D 11/326 - Encres à pigments caractérisées par le dispersant du pigment
C09B 67/00 - Traitements, sans réaction chimique, influençant les propriétés physiques, p. ex. de teintures ou d'impression, des matières colorantes, p. ex. traitement par des solvantsCaractéristiques du procédé de fabrication des préparations tinctorialesPréparations tinctoriales ayant un aspect physique particulier, p. ex. tablettes, feuilles
A composite ion exchange membrane obtainable by a process comprising reacting an ionically-charged membrane with a composition comprising: (a) a monofunctional ethylenically unsaturated monomer having an ionic charge opposite to the charge of the ionically-charged membrane; and (b) a crosslinking agent comprising two or more ethylenically unsaturated groups; wherein the molar ratio of (b):(a) is lower than 0.04 or is zero.
A method for printing on a water-soluble material which comprises the following steps: a) ink jet printing an ink onto a water-soluble material so as to form an image wherein the ink comprises a self-dispersible pigment which comprises a carboxy-functional dispersant crosslinked around a pigment core by a cross-linking agent having at least two groups selected from oxetane, carbodiimide, hydrazide, oxazoline, aziridine, isocyanate, N-methylol, keteneimine, isocyanurate and epoxy groups; b) overprinting the image formed in step A) with a water soluble overprint varnish, also printed material and inks. Also inks, ink-sets and printed water-soluble material.
C09D 11/326 - Encres à pigments caractérisées par le dispersant du pigment
C09D 11/54 - Encres à base de deux liquides, l’un des liquides étant l’encre, l’autre liquide étant une solution de réaction, un fixateur ou une solution de traitement pour l’encre
C09D 11/40 - Jeux d’encres spécialement adaptés à l’impression à jet d’encre à plusieurs couleurs
B41M 7/00 - Traitement ultérieur des travaux imprimés, p. ex. chauffage, irradiation
A composite ion exchange membrane comprising a cationically-charged membrane and an oppositely charged compound covalently bound thereto, the composite ion exchange membrane having: (i) a zeta-potential lower than -8mV; and (ii) an effective charge lower than 20µmol/m2.
A composite membrane comprising: (A) a porous support; (B) optionally a gutter layer; (C) a first discriminating layer; (D) an outermost layer; and (E) a non-discriminating layer interposed between the first discriminating layer (C) and the outermost layer (D); wherein the outermost layer (D) is a discriminating layer comprising a polyimide polymer.
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
A curable composition comprising the components (i) 0 to 60 wt% non-ionic crosslinker(s); (ii) 20 to 85 wt% curable ionic compound(s) comprising an anionic group and at least one ethylenically unsaturated group; (iii) 15 to 45 wt% solvent(s); (iv) 0 to 10 wt% of photoinitiator(s); and (v) 2 to 45 wt% of structure modifier(s); wherein the molar ratio of component (v) : (ii) is 0.25 to 0.65. The compositions are useful for preparing membranes for (reverse) electrodialysis.
B01D 69/10 - Membranes sur supportSupports pour membranes
C09D 4/00 - Compositions de revêtement, p. ex. peintures, vernis ou vernis-laques, à base de composés non macromoléculaires organiques ayant au moins une liaison non saturée carbone-carbone polymérisable
C09D 133/14 - Homopolymères ou copolymères d'esters d'esters contenant des atomes d'halogène, d'azote, de soufre ou d'oxygène en plus de l'oxygène du radical carboxyle
A method for preparing a transparent sheet material comprising an organic, polymeric substrate and inorganic layers on each side of the substrate, the method comprising the steps of: a)providing an apparatus for generating a glow discharge plasma, said apparatus comprising at least two opposing electrodes, a power supply for the electrodes and a treatment space between the electrodes; b)providing the treatment space with a gas mixture at about atmospheric pressure, the gas mixture comprising a reactive gas and a precursor; and c)moving a transparent substrate through the treatment space comprising the gas mixture at an average speed of at least 1 m/min while applying an electrical potential across the electrodes, thereby generating a glow discharge plasma in the treatment space and depositing an inorganic layer on one or both sides of the substrate; wherein the electrodes apply a discharge energy to the substrate of less than 25 J/cm2.
C23C 16/515 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement au moyen de décharges électriques utilisant des décharges pulsées
C23C 16/54 - Appareillage spécialement adapté pour le revêtement en continu
H01J 37/32 - Tubes à décharge en atmosphère gazeuse
H01L 51/00 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives
C08J 7/00 - Traitement chimique ou revêtement d'objets façonnés faits de substances macromoléculaires
A transparent sheet material comprising an organic, polymeric substrate and inorganic layers on each side of the substrate, wherein the overall thickness of the inorganic layer(s) on each side of the substrate is less than 5nm
C23C 16/509 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement au moyen de décharges électriques utilisant des décharges à radiofréquence utilisant des électrodes internes
C23C 16/54 - Appareillage spécialement adapté pour le revêtement en continu
C23C 16/30 - Dépôt de composés, de mélanges ou de solutions solides, p. ex. borures, carbures, nitrures
An ink comprising: (a) from 0.5 to 5 parts of a self-dispersible pigment; (b) from 1 to 10 parts of a styrene acrylic latex binder and/or styrene butadiene latex; (c) from 0 to 5 parts of a glycol selected from the group consisting of ethylene glycol, diethylene glycol, propylene glycol,dipropylene glycolor triethylene glycol; (d) from 1 to 10 parts of 2-pyrrolidone; (e) from 1 to 15 parts of glycerol; (f) from 0.1to 3 parts of an acetylenic surfactant; (g) from 0.001 to 5 parts of biocide; (h) from 0 to 10 parts of a viscosity modifier; and (i) the balance to 100 parts water. Also an ink-jet printing process, a printed substrate, an ink-jet printer ink container and an ink-jet printer with a re-circulating printer head.
C09D 11/106 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
C09D 11/38 - Encres pour l'impression à jet d'encre caractérisées par des additifs non macromoléculaires autres que les solvants, les pigments ou les colorants
An ink comprising: (a)from 1to25 parts of titanium dioxide pigment; (b)from 0to 8parts of a styrene butadiene latex binder; (c)from 0 to 8 parts of a polyurethane latex binder; (d)from 0 to 5 parts of a glycol selected from the group consisting of ethylene glycol, diethylene glycol, propylene glycol,dipropylene glycolor triethylene glycol; (e)from 1 to 10 parts of 2-pyrrolidone; (f)from 1 to 10 parts of glycerol; (g)from 0.01to 2parts ofan acetylenic surfactant; (h)from 0.001 to 5 parts of biocide; (i)from 0 to 10 parts of a viscosity modifier; and (j)the balance to 100 parts water; provided that (b) plus (c) is greater than 0. Also ink jet printing processes, ink-jet ink containers, printed substrates and ink-jet printers.
C09D 11/102 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
C09D 11/106 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
C09D 11/38 - Encres pour l'impression à jet d'encre caractérisées par des additifs non macromoléculaires autres que les solvants, les pigments ou les colorants
An ink comprising: (a) 0.5to 5parts of a self-dispersible pigment; (b) 2 to 8parts of a styrene acrylic latex binderand/or a styrene butadiene latex binder; (c) 0.5 to 5 parts of a polyurethane latex binder; (d) 0 to 5 parts of a glycol selected from the group consisting of ethylene glycol, diethylene glycol, propylene glycol,dipropylene glycolor triethylene glycol; (e) 1 to 10 parts of 2-pyrrolidone; (f) 1 to 15 parts of glycerol; (g) 0.1to 3 parts ofacetylenic surfactant; (h) 0.001 to 5 parts of biocide; (i) 0 to 10 parts of a viscosity modifier; and (j) the balance to 100 parts water. Also ink jet printing processes, ink-jet ink containers,printed substrates and ink-jet printers.
C09D 11/102 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
C09D 11/106 - Encres d’imprimerie à base de résines artificielles contenant des composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
C09D 11/38 - Encres pour l'impression à jet d'encre caractérisées par des additifs non macromoléculaires autres que les solvants, les pigments ou les colorants
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Saunders, Fay Louise
Dodds, Anna Louise
Bayard, Adeline Marie Geraldine
Kara, Bhupendra Vallabh
Abrégé
A process for the production of a target polypeptide is provided. The process comprises expression of an expression vector for expressing a target polypeptide in a host cell, preferably a mammalian cell, the expression vector comprising an expression cassette comprising a polynucleotide encoding a recombinant polypeptide operably linked to a fibronectin secretion leader sequence; and recovering the target polypeptide.
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
C07K 16/06 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux provenant de sérum
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
Fujifilm Diosynth Biotechnologies UK Limited (Royaume‑Uni)
Inventeur(s)
Kara, Bhupendra Vallabh
Lennon, Christopher David John
Abrégé
An expression vector for expressing a target polypeptide in a prokaryotic cell is provided. The vector comprises a promoter operably linked to a polynucleotide encoding the target polypeptide operably linked to a eukaryotic secretion leader sequence, the eukaryotic secretion leader sequence encoding a signal peptide sequence selected from the group consisting of: a) MLKRSSWLATLGLLTVASVSTIVYA; b) MKKATFITCLLAVLLVSNPIWNA; c) MKVSAAALAVILIATALCAPASA; d) MKVSTAFLCLLLTVSAFSAQVLA; and e) MKCLLLALGLALACAAQA. Processes for expressing polypeptides and prokaryotic microorganisms comprising such vectors are also provided.
A process for printing on a water-soluble material using a self-dispersible pigment which comprises a carboxy-functional dispersant crosslinked around a pigment core by a crosslinking agent having at least two groups selected from oxetane, carbodiimide, hydrazide, oxazoline, aziridine, isocyanate, N-methylol, keteneimine, isocyanurate and epoxy groups. Also inks, ink-sets, printed material and ink-jet printers.
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
39 - Services de transport, emballage et entreposage; organisation de voyages
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Storage archive appliances, namely hard disk drive, computer hardware for tape drives and computer software for database management for data processing equipment, namely data processing software, computer file management programs, computer terminals for data processing. (1) Collating, systematic ordering, updating and storage of data in a computer database; organizational project management in the field of electronic data processing; electronic data storage
(2) Physical storage of electronically-stored data or documents
(3) Editing, formatting and transfer of data on to blank CDs (premastering); electronic data security; conversion of data or documents from physical to electronic media; technical project management in the field of electronic data processing; recovery of computer data
A method for preparing an ionically-charged membrane comprising the steps (1) applying a film of curable composition to a support; (2) curing the film of curable composition to give anionically-charged membrane; and (3) removing the ionically-charged membrane from the support; wherein the curable composition comprises a) 5 to 50wt% of curable compound comprising one ethylenically unsaturated group and anionic group; b)10 to 70wt% of crosslinking agent comprising at least two ethylenically unsaturated groups and having a molecular weight of at least 500 dalton per ethylenically unsaturated group; and c) 5 to 60wt% of inert solvent.
A process for preparing a membrane stack comprising the steps of: (i)interposing a curable adhesive between alternate anion exchange membranes and cation exchange; and (ii)curing the adhesive; CHARACTERISED IN THAT said adhesive, when cured, has a Shore A hardness of less than 70 and an elongation at break of at least 50%.
B01D 61/50 - Empilements du type à plaque et cadre
B01D 65/00 - Accessoires ou opérations auxiliaires, en général, pour les procédés ou les appareils de séparation utilisant des membranes semi-perméables
A process for preparing a membrane stack comprising the steps of (i) interposing a curable adhesive between alternate anion exchange membranes and cation exchange; and (ii) curing the adhesive; CHARACTERISED IN THAT said membranes are in a swollen state when step (ii) is performed.
B01D 61/50 - Empilements du type à plaque et cadre
B01D 65/00 - Accessoires ou opérations auxiliaires, en général, pour les procédés ou les appareils de séparation utilisant des membranes semi-perméables
C09D 11/326 - Encres à pigments caractérisées par le dispersant du pigment
C09B 67/00 - Traitements, sans réaction chimique, influençant les propriétés physiques, p. ex. de teintures ou d'impression, des matières colorantes, p. ex. traitement par des solvantsCaractéristiques du procédé de fabrication des préparations tinctorialesPréparations tinctoriales ayant un aspect physique particulier, p. ex. tablettes, feuilles
A disposable, crossflow membrane stack suitable for use in an ion exchange unit, the stack comprising alternate dilution compartments and concentration compartments, each compartment being defined by a flat cation-permeable membrane (2) and a flat anion-permeable membrane (1) and at least two edges along which the cation- permeable and an anion-permeable membranes are permanently secured together wherein the cation-permeable membranes and/ or the anion-permeable membranes have a textured surface profile which keep said membranes apart and/or from touching each other and wherein the edges secured together define the direction in which liquid may flow through the compartments. Also claimed are ion exchange units comprising the stack, optionally comprising a quick- release securement means to allow facile attachment and release of modular units comprising the stacks.
A process for preparing an ion-exchange membrane having a textured surface profile comprising the steps(i) and (ii): (i) screen-printing a radiation-curable composition onto a membrane in a patterned manner; and (ii) irradiating and thereby curing the printed, radiation-curable composition; wherein the radiation-curable composition has a viscosity of at least 30 Pa.s when measured at a shear rate of 0.1 s-1 at 20°C.
09 - Appareils et instruments scientifiques et électriques
35 - Publicité; Affaires commerciales
39 - Services de transport, emballage et entreposage; organisation de voyages
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Magnetic encoders, Data processing apparatus, reading devices, Magnetic tape units for computers, Magnetic data carriers, Optical data carriers, Scanners [data processing equipment], Computer memory devices, Processors (central processing units); Software for reading, systemizing, indexing, recovering, converting and processing stored data. Collating, systematic ordering, updating and storage of data in a computer database; Organizational project management in the field of electronic data processing. Storage (Physical -) of electronically-stored data or documents. Editing, formatting and transfer of data on to blank CDs (premastering); Electronic data back-up; Conversion of data or documents from physical to electronic media; Technical project management in the field of electronic data processing; Recovery of computer data; Electronic data storage.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Cell cultures used in industry and science; mammalian cell
cultures and vectors, being independent replicating pieces
of DNA that can transfer DNA sequences, each for manufacture
and development in the biotechnology industries. Processing and manufacturing of vectors, cell cultures and
recombinant proteins for use in biotechnology industries to
the order and specification of others; manufacture,
processing and production of recombinant proteins for use in
the biotechnology industries to the order and specification
of others. Scientific, industrial and technical research, development
and analysis services relating to the use of mammalian cell
cultures and vectors in the field of biotechnology; process
development, namely, development of processes for the use of
mammalian cell cultures and vectors in the manufacture of
biotechnology products; project studies relating to the use
of mammalian cell cultures and vectors in the field of
biotechnology.
97.
USE OF METE GENE AS AUXOTROPHIC MARKER IN GENETIC CONSTRUCTS
FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (Royaume‑Uni)
Inventeur(s)
Pointon, Jonathan, Anthony
Abrégé
A process for the production of a target polypeptide is provided. The process comprises expressing an expression cassette for the target recombinant polypeptide comprised in a vector in a non-mammalian host, wherein the host is auxotrophic for methionine and lacks the ability to express functional chromosomal Vitamin B12 independent homocysteine methyltransferase. The vector comprises an expression cassette for functional Vitamin B12 independent homocysteine methyltransferase and the host is cultured in a growth medium lacking methionine.
C12N 15/65 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression utilisant des marqueurs
A gas separation module comprising gas separation elements, said elements comprising at least two membrane sheets and a permeate carrier sandwiched between the membrane sheets, wherein the permeate carrier comprises at least two macroporous layers and a gas-impermeable sheet located between the macroporous layers.
B01D 63/10 - Modules à membranes enroulées en spirale
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
A gas separation module comprising one or more gas separation elements, said elements comprising at least two membrane sheets and a permeate carrier sandwiched between the membrane sheets, wherein the contact area of the membrane sheets with the permeate carrier is less than 50%.
B01D 53/22 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par diffusion
B01D 63/10 - Modules à membranes enroulées en spirale
A composite gas membrane comprising: a) a porous support; b) an activated gutter layer; c) a discriminating layer located on the gutter layer;and d)optionally a protective layer on the discriminating layer; wherein the said layers remain in place when a peeling force of 2.5 N/1.5 cm is applied to the outermost of said layers.
