Produits et services

Electrical leads, clinician programming software and battery chargers for implantable spinal cord stimulation systems. Implantable spinal cord stimulation systems comprised of implantable pulse generators (IPGs), external trial stimulators, and external therapy controllers, for use in the treatment of pain.

Abrégé

A system for delivering neurostimulation may include a programming control circuit configured to generate information for programming a stimulation device to control the delivery of the neurostimulation according to a neurostimulation program including a discrete dynamic pattern defined by stimulation parameters including at least one time-varying stimulation parameter. The system may also include a stimulation programming circuit configured to determine the neurostimulation program and including a dynamic pattern composer configured to determine the discrete dynamic pattern. The dynamic pattern composer may include a modulation function generator and a parameter modulator. The modulation function generator may be configured to receive discretization information and to determine a discretized modulation function using the received discretization information. The parameter modulator may be configured to select a stimulation parameter and to produce the at least one time-varying stimulation parameter by modulating the selected parameter using the discretized modulation function.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Systems for facilitating electrical stimulation within a patient's brain and of recording electrical activity within a patient's brain during the implantation of electrode leads in the patient's brain are described. The systems include a modified operating room (OR) cable and/or a sensing adapter that provide electrical connections with the electrode lead(s) and also provide electrical connections to off-lead electrodes that may be configured in electrical contact on the patient's body remote from the electrodes of the electrode lead(s). The off-lead electrodes may be reference electrodes, for example.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/375 - Aménagements structurels, p. ex. boîtiers

Abrégé

Systems for facilitating electrical stimulation within a patient's brain and of recording electrical activity within a patient's brain during the implantation of electrode leads in the patient's brain are described. The systems include a modified operating room (OR) cable and/or a sensing adapter that provide electrical connections with the electrode lead(s) and also provide electrical connections to off-lead electrodes that may be configured in electrical contact on the patient's body remote from the electrodes of the electrode lead(s). The off-lead electrodes may be reference electrodes, for example.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A system for delivering neurostimulation may include a programming control circuit configured to generate information for programming a stimulation device to control the delivery of the neurostimulation according to a neurostimulation program including a discrete dynamic pattern defined by stimulation parameters including at least one time-varying stimulation parameter. The system may also include a stimulation programming circuit configured to determine the neurostimulation program and including a dynamic pattern composer configured to determine the discrete dynamic pattern. The dynamic pattern composer may include a modulation function generator and a parameter modulator. The modulation function generator may be configured to receive discretization information and to determine a discretized modulation function using the received discretization information. The parameter modulator may be configured to select a stimulation parameter and to produce the at least one time-varying stimulation parameter by modulating the selected parameter using the discretized modulation function.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

An example of a system for delivering neurostimulation to a patient and controlling the delivery of neurostimulation using sensors may include a stimulation output circuit, a sensing circuit, and a control circuit. The stimulation output circuit may be configured to deliver the neurostimulation. The sensing circuit may be configured to receive sensed signals from the sensors and to process the sensed signals. The sensing circuit has adjustable settings controlling the processing of the sensed signals. The control circuit may be configured to control the delivery of the neurostimulation using the processed sensed signals and to control the settings of the sensing circuit according to a sequence of sensing blocks each including a set of sensing parameters.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A Graphical User Interface (GUI) for an external device used to program an implantable stimulator device is disclosed. The GUI includes aspects useful in adjusting the current magnitude provided at one or more of the stimulator device's electrodes. In particular, the GUI includes an amplitude slider, which allows the user to slide an indicator to increase or decrease the current magnitude at different rates depending on the length of the slide. The GUI further allows the user to prescribe drop back functionality, which reduces the current magnitude by a prescribed amount when the indicator is released. In one example, drop back functionality can be engaged in accordance with a rate threshold, and thus drop back functionality will only occur when the rate of increase equals or is above the threshold when the control button is released.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Sense amplifier (amp) circuitry for an implantable stimulator device is disclosed useful for sensing neural responses or other voltages in a patient's tissue. The sense amp circuitry comprises a low-voltage and a high-voltage sense amp circuit, either of which may be selected based on an assessment of the magnitude of the voltage at either or both of the inputs connected to selected sensing electrodes. The assessed magnitude, as determined by monitoring circuitry, can be processed by an algorithm to select use of one of the sense amp circuits, selecting the low-voltage sense amp circuit when the magnitude(s) are lower, and the high-voltage sense amp circuit when the magnitude(s) are higher. Furthermore, DC offset compensation circuitry is disclosed to equate the DC levels of the inputs, which may only operate when the high-voltage sense amp is selected.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/378 - Alimentation en courant électrique
• H03F 3/45 - Amplificateurs différentiels

Abrégé

A compliance voltage management algorithm is disclosed for managing the compliance voltage, VH, that powers the DAC circuitry in a stimulator device. A user can use a user interface associated with an external programming device to define a time-varying stimulation waveform to be programmed into the stimulator device. The algorithm analyzes the prescribed waveform and determines a number of groups of pulses that will be treated similarly from a VH management standpoint. Optimal compliance voltages are determined for each group, as are the rise and fall rates at which VH is able to change at transitions between groups. These rise or fall rates in VH are then used to set when the compliance voltage should increase or decrease. For example, the algorithm will automatically set VH to start rising in advance of a transition so that it is at the proper higher value when the transition occurs.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Systems and techniques to determine programming of an implantable electrical neurostimulation device, through chronic pain treatment modeling that evaluates pain experience states and transitions for a patient. In an example, a system to determine programming of a neurostimulation device performs operations to: determine possible pathways to traverse pain experience states of a chronic pain condition, as the possible pathways provide respective paths among the states from a starting state to one or more intermediate states to a goal state; determine transition costs between the states used in the possible pathways, with respective pain experience states being associated with different pain management characteristics of neurostimulation therapy; identify a path of the possible pathways to reach the goal state, based on the transition costs and patient characteristics; and select programming parameters for the neurostimulation device, to provide neurostimulation therapy based on the identified path to achieve the goal state.

Classes IPC  ?

• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local

Abrégé

A connector that includes contact assemblies and non-conductive stack spacers separating the contact assemblies from each other, the contact assemblies and the stack spacers defining a connector lumen configured to receive a portion of an electrical stimulation lead. The contact assemblies and stack spacers are brazed together forming a sealed connector stack that resists passage of fluid between the contact assemblies and stack spacers. Alternatively or additionally, the stack spacers are made of a non-conductive ceramic, crystalline, or glass material.

Classes IPC  ?

• A61N 1/375 - Aménagements structurels, p. ex. boîtiers
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
• B23K 1/00 - Brasage ou débrasage

Abrégé

A system may include a neurostimulator and a processing system configured to provide a stimulation effects map by testing stimulation parameter sets from a plurality of available stimulation parameter sets, acquiring clinical effect data indicative of a patient response to electrical energy delivered to the tissue using at least a first subset of the tested stimulation parameter sets, acquiring sensed data indicative of a sensed response to the electrical energy delivered to the tissue using at least a second subset of the tested stimulation parameter sets, and evaluating parameter sets from the plurality of untested stimulation parameter sets including for each of the evaluated parameter sets, determining an estimated response by estimating at least one of the patient response or the sensed response to the electrical energy using the acquired clinical effect data and the acquired sensed data. A stimulation parameter set may be chosen based on the map.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Techniques are disclosed using a Spinal Cord Stimulation (SCS) Implantable Pulse Generator (IPG) to treat Postural Orthostatic Tachycardia Syndrome (POTS) or other orthostatic intolerance conditions. When treating POTS, SCS is preferably applied to recruit splanchnic nerves, thus modulating recruitment of blood volume to the organs in a patient's splanchnic bed. When employed in this context, non-destructive stimulation is preferably provided to the dorsal horn in the patient's spinal column, which modulates the intermediolateral nucleus (IML) that includes sympathetic pre-ganglionic neurons (SPNs) that ultimately affect the sympathetic nervous system of splanchnic nerves innervating the splanchnic bed. Use of the IPG can be supplemented by use of one or more sensors, such as a heart rate, blood pressure, and/or patient position sensor, which can be used to assess the effectiveness of the stimulation in treating POTS, and to provide closed loop control of the IPG.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Systems and techniques to determine programming of an implantable electrical neurostimulation device, through chronic pain treatment modeling that evaluates pain experience states and transitions for a patient. In an example, a system to determine programming of a neurostimulation device performs operations to: determine possible pathways to traverse pain experience states of a chronic pain condition, as the possible pathways provide respective paths among the states from a starting state to one or more intermediate states to a goal state; determine transition costs between the states used in the possible pathways, with respective pain experience states being associated with different pain management characteristics of neurostimulation therapy; identify a path of the possible pathways to reach the goal state, based on the transition costs and patient characteristics; and select programming parameters for the neurostimulation device, to provide neurostimulation therapy based on the identified path to achieve the goal state.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients

Abrégé

Systems and methods for patient guided neuromodulation therapy are disclosed. An exemplary system comprises a processing system and a memory. The memory may store instructions executable by the processing system to receive a medication schedule from a patient associated with neuromodulation therapy. The instructions may be executable by the processing system to send queries related to symptoms and side effects experienced by the patient. The instructions may be executable by the processing system to determine a parameter for a period of time of medication efficacy. The instructions may be executable by the processing system to determine a change in the parameter for the period of time.

Classes IPC  ?

• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
• G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients

Abrégé

A system may include a neurostimulator and a processing system. The neurostimulator may be configured to deliver electrical energy according to a stimulation parameter set. The stimulation parameter set may include at least one adjustable parameter. The processing system may be configured to perform a testing process to test delivering electrical energy by automatically progressing through a sequence of values for the at least one adjustable parameter in the parameter set. A first value and a second value in the sequence of values are separated by an initial parameter change interval and a second to last value and the last value in the sequence of values are separated by a final parameter change interval. Progressing through the sequence of values includes reducing the parameter change interval from the initial parameter change interval to the final parameter change interval.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients

Abrégé

A system may include a neurostimulator and a processing system configured to provide a stimulation effects map by testing stimulation parameter sets from a plurality of available stimulation parameter sets, acquiring clinical effect data indicative of a patient response to electrical energy delivered to the tissue using at least a first subset of the tested stimulation parameter sets, acquiring sensed data indicative of a sensed response to the electrical energy delivered to the tissue using at least a second subset of the tested stimulation parameter sets, and evaluating parameter sets from the plurality of untested stimulation parameter sets including for each of the evaluated parameter sets, determining an estimated response by estimating at least one of the patient response or the sensed response to the electrical energy using the acquired clinical effect data and the acquired sensed data. A stimulation parameter set may be chosen based on the map.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication

Abrégé

Systems and methods for patient guided neuromodulation therapy are disclosed. An exemplary system comprises a processing system and a memory. The memory may store instructions executable by the processing system to receive a medication schedule from a patient associated with neuromodulation therapy. The instructions may be executable by the processing system to send queries related to symptoms and side effects experienced by the patient. The instructions may be executable by the processing system to determine a parameter for a. period of time of medication efficacy. The instructions may be executable by the processing system to determine a change in the parameter for the period of time.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• G16H 20/00 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

A system may include a neurostimulator and a processing system. The neurostimulator may be configured to deliver electrical energy according to a stimulation parameter set. The stimulation parameter set may include at least one adjustable parameter. The processing system may be configured to perform a testing process to test delivering electrical energy by automatically progressing through a sequence of values for the at least one adjustable parameter in the parameter set. A first value and a second value in the sequence of values are separated by an initial parameter change interval and a second to last value and the last value in the sequence of values are separated by a final parameter change interval. Progressing through the sequence of values includes reducing the parameter change interval from the initial parameter change interval to the final parameter change interval.

Classes IPC  ?

• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Techniques are disclosed using a Spinal Cord Stimulation (SCS) Implantable Pulse Generator (IPG) to treat Postural Orthostatic Tachycardia Syndrome (POTS) or other orthostatic intolerance conditions. When treating POTS, SCS is preferably applied to recruit splanchnic nerves, thus modulating recruitment of blood volume to the organs in a patient's splanchnic bed. When employed in this context, non-destructive stimulation is preferably provided to the dorsal horn in the patient's spinal column, which modulates the intermediolateral nucleus (IML) that includes sympathetic pre-ganglionic neurons (SPNs) that ultimately affect the sympathetic nervous system of splanchnic nerves innervating the splanchnic bed. Use of the IPG can be supplemented by use of one or more sensors, such as a heart rate, blood pressure, and/or patient position sensor, which can be used to assess the effectiveness of the stimulation in treating POTS, and to provide closed loop control of the IPG.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for providing deep brain stimulation (DBS) for a patient are described. Electrical stimulation is provided to a. patient's brain and evoked potentials (EPs) are recorded at two or more electrodes. The EPs evoked and/or recorded at different electrodes are used to estimate if the respective electrodes are located in the same or different anatomical brain regions. The EPs may also be used to predict or suggest appropriate stimulation rates for therapeutic stimulation.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for providing deep brain stimulation (DBS) for a patient are described. Electrical stimulation is provided to a patient's brain and evoked potentials (EPs) are recorded at two or more electrodes. The EPs evoked and/or recorded at different electrodes are used to estimate if the respective electrodes are located in the same or different anatomical brain regions. The EPs may also be used to predict or suggest appropriate stimulation rates for therapeutic stimulation.

Classes IPC  ?

• A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
• A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie

Abrégé

This document discusses a neurostimulation device. The neurostimulation device includes a stimulation circuit configured to deliver electrical neurostimulation energy to a subject when coupled to an implantable lead, a physiological sensor circuit to produce a sensed physiological signal, a memory to store dorsal cerebrospinal fluid (dCSF) thickness data for the subject, and a control circuit operatively coupled to the stimulation circuit, the physiological sensor circuit, and the memory. The control circuit is configured to determine physiological information of the subject using the sensed physiological signal, determine a value of dCSF thickness according to the physiological information and the stored dCSF thickness data, and set a parameter of the electrical neurostimulation therapy according to the determined value of dCSF thickness.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61B 5/0537 - Mesure de la composition du corps par impédance, p. ex. de l’hydratation des tissus ou de la teneur en graisses
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Systems and methods for coordination of medication adjustment for neuromodulation therapy are disclosed. An exemplary system comprises a processing system. The processing system may receive medication data associated with administration of medication from a. patient in an absence of administering electrostimulation to the patient. The processing system may receive stimulation data, associated with administration of electrostimulation therapy to the patient while the patient is not being administered medication. The processing system may compare the medication data to the stimulation data to provide a comparison. The processing system may generate a medication schedule and an electrostimulation schedule based on the comparison to increase efficacy of therapy and minimize side effects.

Classes IPC  ?

• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

Systems and methods for coordinating electrostimulation and medication for neuromodulation therapy are disclosed. An exemplary system comprises a processing system. The processing system may use a model to determine neural tissue activated by medication administered to a patient. The processing system may determine a stimulation parameter from a stimulation parameter set that activates the neural tissue during delivery of electrostimulation. The processing system may map the neural tissue activated by the medication to the stimulation parameter. The processing system may select the stimulation parameter from the stimulation parameter set in response to the medication being associated with the patient.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices

Abrégé

Systems and methods for coordination of medication adjustment for neuromodulation therapy are disclosed. An exemplary system comprises a processing system. The processing system may receive medication data associated with administration of medication from a patient in an absence of administering electrostimulation to the patient. The processing system may receive stimulation data associated with administration of electrostimulation therapy to the patient while the patient is not being administered medication. The processing system may compare the medication data to the stimulation data to provide a comparison. The processing system may generate a medication schedule and an electrostimulation schedule based on the comparison to increase efficacy of therapy and minimize side effects.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices

Abrégé

Regulator circuitry for producing a regulated output voltage in an implantable stimulation device and associated methods are disclosed. The regulator circuitry is particularly useful where a load current drawn from the output voltage involves transients, such as occurs when the output voltage is used to power a charge pump that creates a higher power supply voltage (e.g., a compliance voltage) in the device. The output current is sampled and downscaled in the regulator, and is further mirrored and filtered. This filtered current provides a control voltage in which transients are minimized and smoothed, and which is more suitable for use as a feedback voltage when producing the output voltage.

Classes IPC  ?

• G05F 1/575 - Régulation de la tension ou de l'intensité là où la variable effectivement régulée par le dispositif de réglage final est du type continu utilisant des dispositifs à semi-conducteurs en série avec la charge comme dispositifs de réglage final caractérisé par le circuit de rétroaction
• G05F 3/26 - Miroirs de courant

Abrégé

Sensing circuitry for an implantable stimulator device is disclosed. The sensing circuitry includes a downselector with switching networks used to couple selected electrode nodes and/or DC voltages to one or more sense amps. The switching networks comprise high-voltage devices that are controlled in accordance with a high-voltage power supply voltage VH. VH may be generated by a boost circuit, and may be set to the higher of a boosted voltage and a compliance voltage that powers the stimulation circuitry. The switching networks include three switches, some of which may comprise transfer gates. The downselector can be controlled to couple one or more electrodes nodes to a particular sense amp during sensing durations. The downselector can also be controlled during stimulation durations to couple one or more electrodes nodes together, thus supplementing operation of the stimulation circuitry.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61B 5/24 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci

Abrégé

Sensing circuitry for an implantable stimulator device is disclosed. The sensing circuitry includes a downselector with switching networks used to couple selected electrode nodes and/or DC voltages to one or more sense amps. The switching networks comprise high-voltage devices that are controlled in accordance with a high-voltage power supply voltage VH. VH may be generated by a boost circuit, and may be set to the higher of a boosted voltage and a compliance voltage that powers the stimulation circuitry. The switching networks include three switches, some of which may comprise transfer gates. The downselector can be controlled to couple one or more electrodes nodes to a particular sense amp during sensing durations. The downselector can also be controlled during stimulation durations to couple one or more electrodes nodes together, thus supplementing operation of the stimulation circuitry.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/20 - Application de courants électriques par électrodes de contact courants continus ininterrompus

Abrégé

Methods and systems for detecting if a stimulation lead implanted in a patient's brain has moved. Lead movement occurring between a first time and a second time may be determined by comparing features extracted from evoked potentials recorded at the two times. The disclosed methods and systems are particularly useful for determining if a stimulation lead has moved between the time it was implanted in the patient's brain and the time that stimulation parameters are being optimized. Lead movement during implantation, during parameter optimization, and during or between other lead optimization processes may be determined as well.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

A system may include an electrode set including at least one electrode, and a neurostimulator. The neurostimulator may include a tonic waveform generator, a neurostimulation modifier, and a neurostimulator output. The tonic waveform generator may be configured to generate a train of tonic pulses. The tonic pulses may have a uniform pulse-to-pulse interval. The neurostimulation modifier may be configured to apply a neurostimulation-effect modulation to modify the train of tonic pulses. The neurostimulator output may be configured to use the modified train of pulses to deliver a sequence of electrical pulses to a neural target using the electrode set. The neurostimulation modifier may be configured to apply the neurostimulation¬ effect modulation to change at least one stimulation parameter for at least a portion of the train of tonic pulses to enhance or reduce a neurostimulation effect for one or more pulses within the sequence of electrical pulses.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A system may include an electrode set including at least one electrode, and a neurostimulator. The neurostimulator may include a tonic waveform generator, a neurostimulation modifier, and a neurostimulator output. The tonic waveform generator may be configured to generate a train of tonic pulses. The tonic pulses may have a uniform pulse-to-pulse interval. The neurostimulation modifier may be configured to apply a neurostimulation-effect modulation to modify the train of tonic pulses. The neurostimulator output may be configured to use the modified train of pulses to deliver a sequence of electrical pulses to a neural target using the electrode set. The neurostimulation modifier may be configured to apply the neurostimulation-effect modulation to change at least one stimulation parameter for at least a portion of the train of tonic pulses to enhance or reduce a neurostimulation effect for one or more pulses within the sequence of electrical pulses.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Methods and systems for programming stimulation parameters for an implantable medical device for neuromodulation, such as spinal cord stimulation (SCS) are disclosed. The stimulation parameters define user-configured waveforms having at least a first phase having a first polarity and a second phase having a second polarity, wherein the first and second phases are separated by an interphase interval (IPI). By delivering user-configured waveforms with different IPIs, stimulation geometry, and other waveform settings, therapeutic asynchronous activation of dorsal column fibers can be obtained.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61B 5/24 - Détection, mesure ou enregistrement de signaux bioélectriques ou biomagnétiques du corps ou de parties de celui-ci
• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

A system may include a programmer for a neurostimulator. The neurostimulator may have a plurality of electrodes, and the programmer may include a processor and a memory including instructions which when executed by the processor perform a method that includes: determining a relative geometry between a stimulation electrode configuration and a sensing electrode configuration to reduce a stimulation artifact; using the determined relative geometry to determine the stimulation electrode configuration and the sensing electrode configuration, wherein the stimulation electrode configuration is determined to both stimulate a neural target and cause an evoked potential and the sensing electrode configuration is determined to sense the evoked potential; and programming the neurostimulator with the stimulation electrode configuration and the sensing electrode configuration that have the relative geometry to reduce the stimulation artifact.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

A system may include a neurostimulator. The neurostimulator may include a waveform generator configured to deliver neurostimulation, a controller operably connected to the waveform generator to control the neurostimulation, and an accelerometer. The controller may be configured to monitor an output of the accelerometer, detect an event from the output of the accelerometer, and perform a neurostimulator action in response to the detected event. The event may include at least one intentional user interaction with the neurostimulator or an unintended neurostimulator event.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which a stimulation location in an electrode array is determined. Preferably, the supra-perception stimulation comprises a bipole formed using actively-driven symmetric biphasic waveforms at active ones of the electrodes in the array. After determining the location, a perception threshold for the bipole at the location is determined and stored, and an amplitude of the stimulation is reduced below the perception threshold to provide a sub-perception stimulation bipole. The determined perception threshold may be used to compose one or more programs using stimulation amplitudes that are a percentage of the determined perception threshold. The one or more programs may run according to schedule. For example, the programs may be interleaved.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A system for delivering neurostimulation to a patient using a stimulation device may include a programming control circuit and a stimulation programming circuit. The programming control circuit may be configured to generate information for programming the stimulation device to control the delivery of the neurostimulation according to a dynamic stimulation pattern defined by stimulation parameters including at least one time-varying stimulation parameter. The stimulation programming circuit includes a dynamic pattern composer, which may be configured to determine the dynamic stimulation pattern based on a targeted modulation of a neural response by the neurostimulation according to the dynamic stimulation pattern. The neural response is a response of the patient to the delivery of the neurostimulation.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Systems and methods for collecting evoked responses (ERs), and using the same to guide neuromodulation are disclosed. An exemplary system includes an electrostimulator to provide electrostimulation to a neural target, a sensing circuit to sense ERs, and a controller circuit to collect first ERs sensed from a group of sensing electrodes in response to electrostimulation through first one or more stimulating electrodes. The controller circuit performs a quality check of the first ERs, determine or update an ER sampling routine including timings or an order of performing multiple stimulation and ER collection tests, and sequentially execute the multiple stimulation and ER collection tests, and collect second ERs according to the determined or updated ER sampling routine. When the second ERs satisfy an acceptance criterion, a recommendation can be provided to a user to reposition the lead or to set or adjust a stimulation setting.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/377 - Électroencéphalographie [EEG] utilisant des réponses provoquées
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A system for delivering neurostimulation from a stimulation device to a targeted area on a patient may include a programming control circuit and a stimulation programming circuit. The programming control circuit may be configured to generate information for programming the stimulation device to control the delivery of the neurostimulation according to a stimulation program. The stimulation programming circuit may be configured to receive a stimulation field and a stimulation coverage and to determine the stimulation program by including at least one dynamic stimulation pattern configured to expand the stimulation coverage resulting from delivering the neurostimulation to the stimulation field. The stimulation coverage is a portion of the targeted area effectively stimulated by the neurostimulation delivered to the stimulation field. The dynamic stimulation pattern is defined by at least one time-varying stimulation waveform parameter of the stimulation waveform parameters.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A system may include a neurostimulator. The neurostimulator may include a waveform generator configured to deliver neurostimulation, a controller operably connected to the waveform generator to control the neurostimulation, and an accelerometer. The controller may be configured to monitor an output of the accelerometer, detect an event from the output of the accelerometer, and perform a neurostimulator action in response to the detected event. The event may include at least one intentional user interaction with the neurostimulator or an unintended neurostimulator event.

Classes IPC  ?

• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

An RF ablation system includes an RF electrode, a split-electrode ground pad, and an RF generator. The split-electrode ground pad includes a first ground pad, a second ground pad, and a ground-pad cable coupled to the first and second ground pads. The RF generator is configured to deliver RF energy from the RF generator through the RF electrode to patient tissue of a patient to cause ablation using the split-electrode ground pad as a counter-electrode. The RF generator includes ports, a display, a memory, and a processor. The processor is configured to execute instructions including: a) prior to delivery of the RF energy, determining a value indicative of an impedance between the first ground pad and the second ground pad; b) displaying, on the display, a representation of the first value; and c) repeating steps a) and b) until a termination condition is met.

Classes IPC  ?

• A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
• A61B 18/16 - Électrodes neutres ou passives pour mise à la terre

Abrégé

Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during "sweet spot searching" during which a stimulation location in an electrode array is determined. Preferably, the supra-perception stimulation comprises a bipole formed using actively-driven symmetric biphasic waveforms at active ones of the electrodes in the array. After determining the location, a perception threshold for the bipole at the location is determined and stored, and an amplitude of the stimulation is reduced below the perception threshold to provide a sub-perception stimulation bipole. The determined perception threshold may be used to compose one or more programs using stimulation amplitudes that are a percentage of the determined perception threshold. The one or more programs may run according to schedule. For example, the programs may be interleaved.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/04 - Électrodes
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A system may include a neural stimulator connected to at least one lead having a plurality of electrodes. The neural stimulator may be configured to store at least two preset programs, and to test each of the electrodes with equal amounts of cathodic energy by implementing at least two preset programs. Each of the preset programs may be configured to control delivery of neuromodulation to deliver neuromodulation energy using a different set of active electrodes from the plurality of electrodes. For each of the preset programs, the active electrodes may include at least two cathodic electrodes and at least two anodic electrodes, a total cathodic contribution for the neuromodulation energy may be evenly fractionalized across each of the at least two cathodic electrodes, and a total anodic contribution for the neuromodulation energy may be evenly fractionalized across each of the at least two anodic electrodes.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A system may include a programmer for a neurostimulator. The neurostimulator may have a plurality of electrodes, and the programmer may include a processor and a memory including instructions which when executed by the processor perform a method that includes: determining a relative geometry between a stimulation electrode configuration and a sensing electrode configuration to reduce a stimulation artifact; using the determined relative geometry to determine the stimulation electrode configuration and the sensing electrode configuration, wherein the stimulation electrode configuration is determined to both stimulate a neural target and cause an evoked potential and the sensing electrode configuration is determined to sense the evoked potential; and programming the neurostimulator with the stimulation electrode configuration and the sensing electrode configuration that have the relative geometry to reduce the stimulation artifact.

Classes IPC  ?

• A61N 1/37 - SurveillanceProtection

Abrégé

Systems and methods for schedule neuromodulation therapy are disclosed. An exemplary system comprises an electrostimulator and a controller. The electrostimulator can be configured to provide electrostimulation to a neural target of a patient. The controller circuit can be operably connected to the electrostimulator. The controller circuit can be configured to determine an activity parameter based on a schedule parameter of the patient, wherein the schedule parameter is associated with a schedule of the patient; determine stimulation parameters based on the activity parameter; and deliver the electrostimulation to the neural target of the patient using the stimulation parameters.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• A61N 1/04 - Électrodes

Abrégé

Systems and methods for programming a neuromodulation therapy to a neuromodulation device are disclosed. An exemplary system includes an electrostimulator to provide electrostimulation to a neural target, and a programmer device operable by a user to program the electrostimulator. The programmer device includes a graphical user interface (GUI), and a controller circuit to controllably display on the GUI the neural target, and receive a user input to create or modify a graphical stimulation field representation with respect to the neural target. Based on the graphical stimulation field representation, the controller circuit can estimate a stimulation setting, including determining a stimulation test volume, activated by an application of the estimated stimulation setting, that substantially matches the received graphical stimulation field representation. The electrostimulator can deliver electrostimulation energy in accordance with the estimated stimulation setting.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

Methods and systems for providing deep brain stimulation (DBS) for a patient are described. Evoked potentials (EPs) evoked by the stimulation are recorded and compared to modeled EPs. The modeled EPs are determined based on an overlap of stimulation field models (SFMs) for a given set of stimulation parameters with a target volume of the patient's brain, the target region being the source of the EPs. The target volume may include the patient's subthalamic nucleus (STN), for example. The modeled EPs are used to predict electrical signals that will be sensed at recording electrodes of an electrode lead. The recorded EPs can be compared to the modeled electrical signals to guide aspects of the stimulation therapy.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Systems and methods for schedule neuromodulation therapy are disclosed. An exemplary system comprises an electrostimulator and a controller. The electrostimulator can be configured to provide electrostimulation to a neural target of a patient. The controller circuit can be operably connected to the electrostimulator. The controller circuit can be configured to determine an activity parameter based on a schedule parameter of the patient, wherein the schedule parameter is associated with a schedule of the patient; determine stimulation parameters based on the activity parameter; and deliver the electrostimulation to the neural target of the patient using the stimulation parameters.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• G16H 10/20 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des essais ou des questionnaires cliniques électroniques
• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture

Abrégé

Methods and systems for providing deep brain stimulation (DBS) for a patient are described. Evoked potentials (EPs) evoked by the stimulation are recorded and compared to modeled EPs. The modeled EPs are determined based on an overlap of stimulation field models (SFMs) for a given set of stimulation parameters with a target volume of the patient's brain, the target region being the source of the EPs. The target volume may include the patient's subthalamic nucleus (STN), for example. The modeled EPs are used to predict electrical signals that will be sensed at recording electrodes of an electrode lead. The recorded EPs can be compared to the modeled electrical signals to guide aspects of the stimulation therapy.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

An RF ablation system includes an RF electrode, a split-electrode ground pad, and an RF generator. The split-electrode ground pad includes a first ground pad, a second ground pad, and a ground-pad cable coupled to the first and second ground pads. The RF generator is configured to deliver RF energy from the RF generator through the RF electrode to patient tissue of a patient to cause ablation using the split-electrode ground pad as a counter-electrode. The RF generator includes ports, a display, a memory, and a processor. The processor is configured to execute instructions including: a) prior to delivery of the RF energy, determining a value indicative of an impedance between the first ground pad and the second ground pad; b) displaying, on the display, a representation of the first value; and c) repeating steps a) and b) until a termination condition is met.

Classes IPC  ?

• A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif
• A61N 1/06 - Électrodes pour traitement à haute fréquence
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication

Abrégé

A system for delivering neurostimulation to a patient using a stimulation device may include a programming control circuit and a stimulation programming circuit. The programming control circuit may be configured to generate information for programming the stimulation device to control the delivery of the neurostimulation according to a dynamic stimulation pattern defined by stimulation parameters including at least one time-varying stimulation parameter. The stimulation programming circuit includes a dynamic pattern composer, which may be configured to determine the dynamic stimulation pattern based on a targeted modulation of a neural response by the neurostimulation according to the dynamic stimulation pattern. The neural response is a response of the patient to the delivery of the neurostimulation.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Systems and methods for collecting evoked responses (ERs), and using the same to guide neuromodulation are disclosed. An exemplary system includes an electrostimulator to provide electrostimulation to a neural target, a sensing circuit to sense ERs, and a controller circuit to collect first ERs sensed from a group of sensing electrodes in response to electrostimulation through first one or more stimulating electrodes. The controller circuit performs a quality check of the first ERs, determine or update an ER sampling routine including timings or an order of performing multiple stimulation and ER collection tests, and sequentially execute the multiple stimulation and ER collection tests, and collect second ERs according to the determined or updated ER sampling routine. When the second ERs satisfy an acceptance criterion, a recommendation can be provided to a user to reposition the lead or to set or adjust a stimulation setting.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Systems and methods for programming a neuromodulation therapy to a neuromodulation device are disclosed. An exemplary system includes an electrostimulator to provide electrostimulation to a neural target, and a programmer device operable by a user to program the electrostimulator. The programmer device includes a graphical user interface (GUI), and a controller circuit to controllably display on the GUI the neural target, and receive a user input to create or modify a graphical stimulation field representation with respect to the neural target. Based on the graphical stimulation field representation, the controller circuit can estimate a stimulation setting, including determining a stimulation test volume, activated by an application of the estimated stimulation setting, that substantially matches the received graphical stimulation field representation. The electrostimulator can deliver electrostimulation energy in accordance with the estimated stimulation setting.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A system for delivering neurostimulation from a stimulation device to a targeted area on a patient may include a programming control circuit and a stimulation programming circuit. The programming control circuit may be configured to generate information for programming the stimulation device to control the delivery of the neurostimulation according to a stimulation program. The stimulation programming circuit may be configured to receive a stimulation field and a stimulation coverage and to determine the stimulation program by including at least one dynamic stimulation pattern configured to expand the stimulation coverage resulting from delivering the neurostimulation to the stimulation field. The stimulation coverage is a portion of the targeted area effectively stimulated by the neurostimulation delivered to the stimulation field. The dynamic stimulation pattern is defined by at least one time-varying stimulation waveform parameter of the stimulation waveform parameters.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for stimulation of the vagus nerve of a patient using a stimulation system is described herein. The stimulation system including a control module and at least one stimulation lead coupleable to the control module, the at least one stimulation lead including a plurality of electrodes. The method includes implanting the at least one stimulation lead percutaneously or through an opening in the carotid sheath with placement of the electrodes proximate to the vagus nerve for stimulation of the vagus nerve; implanting the control module remote from the vagus nerve; generating stimulation signals using the control module; and delivering the stimulation signals from the control module through at least one of the electrodes of the at least one stimulation lead to stimulate the vagus nerve of the patient.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

A cuff lead arrangement includes a first cuff lead having a first cuff body; first stimulation emitters (for example, electrodes) disposed on an interior surface of the first cuff body; a first lead body coupled to the first cuff body; first conductors electrically coupled to the first stimulation emitters and extending along the first lead body; and at least one first connection element. The cuff lead arrangement further includes a second cuff lead having a second cuff body; second stimulation emitters disposed on an interior surface of the second cuff body; a second lead body coupled to the second cuff body; second conductors electrically coupled to the second stimulation emitters and extending along the second lead body; and at least one second female connection element configured to receive the at least one first male connection element to conjoin the first cuff lead to the second cuff lead.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A multi-modal method of stimulation to provide therapy for an epilepsy patient. A neuroprotective therapy including both an electrical modulation signal and an optical modulation signal is generated on a periodic or scheduled basis. The patient is monitored, and if a trigger condition arises indicating one of potential seizure onset, seizure onset, or an ongoing seizure, a symptom modulation therapy is initiated. The neuroprotective therapy and the symptom modulation therapy may have different targets and other parameters.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux

Abrégé

A multi-modal method of stimulation to provide therapy for an epilepsy patient. A neuroprotective therapy including both an electrical modulation signal and an optical modulation signal is generated on a periodic or scheduled basis. The patient is monitored, and if a trigger condition arises indicating one of potential seizure onset, seizure onset, or an ongoing seizure, a symptom modulation therapy is initiated. The neuroprotective therapy and the symptom modulation therapy may have different targets and other parameters.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux

Abrégé

A system may include a neurostimulator and a programmer. The neurostimulator may have a plurality of electrodes, and may be configured to deliver neurostimulation by delivering neurostimulation pulses of a first polarity to a neural target using at least one stimulation electrode from the plurality of electrodes and passively recovering charge using a first number of one or more passive electrodes from the plurality of electrodes. The programmer may have a user interface configured to receive a user input for changing a number of passive electrodes used to passively recover charge from the first number to a second number. The programmer may be configured to control the neurostimulator to passively recover charge using the second number of passive electrodes. Some examples may include fractionalization to control the contribution of each passive electrode used to recover charge. A variable impedance may be used to control a relative charge recovery current.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Systems and methods for reducing neurostimulation electrode configuration and parameter search space and controlling electrostimulation are discussed. An exemplary system includes an implantable stimulator to provide electrostimulation via a lead comprising a plurality of electrodes, and a programming device. The programing device receives electrode position information relative to an anatomical region of interest or physiological signals respectively sensed by the plurality of electrodes, and identifies a search space of electrode configurations and parameter values for the lead with respect to the neural target. The programing device can determine a target stimulation setting based on a clinical response to electrostimulation delivered using electrodes and stimulation parameter values from the identified search space, and generate a control signal to the control the implantable stimulator to deliver electrostimulation in accordance with the target stimulation setting.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

A system may include a neurostimulator and a programmer. The neurostimulator may have a plurality of electrodes, and may be configured to deliver neurostimulation by delivering neurostimulation pulses of a first polarity to a neural target using at least one stimulation electrode from the plurality of electrodes and passively recovering charge using a first number of one or more passive electrodes from the plurality of electrodes. The programmer may have a user interface configured to receive a user input for changing a number of passive electrodes used to passively recover charge from the first number to a second number. The programmer may be configured to control the neurostimulator to passively recover charge using the second number of passive electrodes. Some examples may include fractionalization to control the contribution of each passive electrode used to recover charge. A variable impedance may be used to control a relative charge recovery current.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Produits et services

Implantable spinal cord stimulation systems comprised of implantable pulse generators (IPGs), electrical leads, external trial stimulators, external therapy controllers, clinician programming software, and battery chargers, for use in the treatment of pain

Abrégé

Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/06 - Électrodes pour traitement à haute fréquence
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

The problem of a potentially high amount of supra-threshold charge passing through the patient's tissue at the end of an Implantable Pulse Generator (IPG) program is addressed by circuitry that periodically dissipates only small amount of the charge stored on capacitances (e.g., DC-blocking capacitors) during a pulsed post-program recovery period. This occurs by periodically activating control signals to turn on passive recovery switches to form a series of discharge pulses each dissipating a sub-threshold amount of charge. Such periodic pulsed dissipation may extend the duration of post-program recovery, but is not likely to be noticeable by the patient when the programming in the IPG changes from a first to a second program. Periodic pulsed dissipation of charge may also be used during a program, such as between stimulation pulses.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/375 - Aménagements structurels, p. ex. boîtiers

Abrégé

Systems and methods are disclosed to permit a patient to use his external controller to move the location of stimulation in an implantable stimulator system. The external controller can be programmed with a steering algorithm, which prompts the patient to enter certain data regarding their symptoms (e.g., pain), such as pain scores and stimulation coverage. Such data is preferably entered for a plurality of different regions of the patient's body. The algorithm can compute for each body regions a targeting precision value (TP), and from these values determine a steering vector D that suggests a direction and/or a magnitude that stimulation can be moved in the electrode array to more precisely target the patient's pain. The patient may then move the location of the stimulation in accordance with the steering vector using their external controller. The algorithm can be repeated if necessary to again move the stimulation.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/06 - Électrodes pour traitement à haute fréquence

Abrégé

Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/06 - Électrodes pour traitement à haute fréquence
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A system for automated programming of stimulation devices uses machine learning with multimodal medical imaging data to determine optimal patient-specific parameters. The system stores voxel-level intensity and functional imaging data from patients who previously underwent stimulation therapy. Similarity metrics calculated directly between the raw imaging data are used to cluster patients into phenotypic groups. Known therapeutic outcomes for each patient are linked to the associated stimulation parameters. For a new patient, biomarkers are extracted from their medical imaging data and used to identify phenotypically similar groups. The stimulation parameters with beneficial outcomes in those groups are analyzed to determine target recommended settings or discard suboptimal settings for the new patient. This data-driven approach leverages machine learning on multimodal medical imaging to automate patient-specific programming of stimulation therapy devices for optimal therapeutic benefit without requiring spatial normalization or atlas registration.

Classes IPC  ?

• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A system for automated programming of stimulation devices uses machine learning with multimodal medical imaging data to determine optimal patient-specific parameters. The system stores voxel-level intensity and functional imaging data from patients who previously underwent stimulation therapy. Similarity metrics calculated directly between the raw imaging data are used to cluster patients into phenotypic groups. Known therapeutic outcomes for each patient are linked to the associated stimulation parameters. For a new patient, biomarkers are extracted from their medical imaging data and used to identify phenotypically similar groups. The stimulation parameters with beneficial outcomes in those groups are analyzed to determine target recommended settings or discard suboptimal settings for the new patient. This data-driven approach leverages machine learning on multimodal medical imaging to automate patient-specific programming of stimulation therapy devices for optimal therapeutic benefit without requiring spatial normalization or atlas registration.

Classes IPC  ?

• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
• G06T 7/00 - Analyse d'image
• G16B 20/40 - Génétique de populationDéséquilibre de liaison
• G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients

Abrégé

A system and method for automated neurostimulation programming uses machine learning to determine target stimulation or discard suboptimal parameters based on actual or anticipated clinical effects. The system includes processors to generate a database of previously acquired lead and/or brain images, tested stimulation settings and associated clinical effects. A region of interest surrounding at least one stimulation lead is identified. Stimulation settings linked to specific clinical effects, including beneficial or detrimental effects, are determined for the region of interest. A trained machine learning model identifies desirable, undesirable, target, or other stimulation parameter values for a new patient by classifying or regressing raw imaging data from the region of interest. The model is trained to recommend settings that produce desired clinical effects. An output provides the target stimulation parameter values predicted to maximize therapeutic benefit and minimize side effects. This enables automated programming of neurostimulation devices through data-driven machine learning based on clinical outcomes.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A charging system for an Implantable Medical Device (IMD) is disclosed having a charging coil and one or more sense coils preferably housed in a charging coil assembly coupled to an electronics module by a cable. The charging coil is preferably a wire winding, while the sense coils are preferably formed in one or more traces of a circuit board. One or more voltages induced on the one or more sense coils can be used to determine one or more parameters (magnitude, phase angle, resonant frequency) indicative of the position between the charging coil and the IMD, which position may include the radial offset and possibly also the depth of the charging coil relative to the IMD. Knowing the position, the power of the magnetic field produced by the charging coil can be adjusted to compensate for the position.

Classes IPC  ?

• A61N 1/378 - Alimentation en courant électrique
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• H01F 27/28 - BobinesEnroulementsConnexions conductrices
• H01F 38/14 - Couplages inductifs
• H02J 7/00 - Circuits pour la charge ou la dépolarisation des batteries ou pour alimenter des charges par des batteries
• H02J 50/00 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique
• H02J 50/12 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique utilisant un couplage inductif du type couplage à résonance
• H02J 50/80 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre l’échange de données, concernant l’alimentation ou la distribution d’énergie électrique, entre les dispositifs de transmission et les dispositifs de réception
• H02J 50/90 - Circuits ou systèmes pour l'alimentation ou la distribution sans fil d'énergie électrique mettant en œuvre la détection ou l'optimisation de la position, p. ex. de l'alignement

Abrégé

A system and method for automated neurostimulation programming uses machine learning to determine target stimulation or discard suboptimal parameters based on actual or anticipated clinical effects. The system includes processors to generate a database of previously acquired lead and/or brain images, tested stimulation settings and associated clinical effects. A region of interest surrounding at least one stimulation lead is identified. Stimulation settings linked to specific clinical effects, including beneficial or detrimental effects, are determined for the region of interest. A trained machine learning model identifies desirable, undesirable, target, or other stimulation parameter values for a new patient by classifying or regressing raw imaging data, from the region of interest. The model is trained to recommend settings that produce desired clinical effects. An output provides the target stimulation parameter values predicted to maximize therapeutic benefit and minimize side effects. This enables automated programming of neurostimulation devices through data-driven machine learning based on clinical outcomes.

Classes IPC  ?

• G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
• G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• G06N 20/00 - Apprentissage automatique
• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

Systems and methods for adaptive neuromodulation based on evoked responses are disclosed. An exemplary system comprises at least one lead, an electrostimulator to provide electrostimulation to a neural target, a sensing circuit to sense ERs to electrostimulation, and a controller circuit. In response to electrostimulation delivered to the neural target in accordance with a stimulation setting via a stimulating electrode, the controller circuit can collect sensed ERs to the electrostimulation using at least one sensing electrode on the at least one lead and determine a first stimulation threshold for a stimulation parameter based on a first sensed threshold of the collected sensed ERs. The first stimulation threshold can be a stimulation value at which a change in the collected sensed ERs occurs.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

This document discusses a neurostimulation device. The neurostimulation device includes a stimulation circuit; a sensing circuit to sense evoked synaptic activity potential (ESAP) signals when coupled to the implantable lead, and a control circuit. The control circuit is configured to initiate delivery of neurostimulation energy by the stimulation circuit, initiate sensing by the sensing circuit of ESAP signals produced by the delivery of neurostimulation energy, change at least one parameter of the neurostimulation energy and continue the sensing of the ESAP signals, compare the sensed ESAP signals to a stored best sensed ESAP signal, wherein the best sensed ESAP signal was previously sensed at a recorded anatomical location using a different trial lead, and determine neurostimulation therapy parameters including a neurostimulation location to produce a best match ESAP signal at the recorded anatomical location that is a closest match to the stored best sensed ESAP signals.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61B 5/377 - Électroencéphalographie [EEG] utilisant des réponses provoquées
• A61B 5/388 - Études de la conduction nerveuse, p. ex. détection du potentiel d’action d’un nerf périphérique
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Algorithms for determining optimal low-frequency and sub-perception spinal cord stimulation for a patient are disclosed. A spread bipole is preferably used both to position the stimulation to target a patient's pain, and to provide the resulting therapy. The stimulation is provided at very low frequencies, such as 10 Hz or less, and preferably 2 Hz. Further, sub-perception is provided by the use of lower amplitudes and at longer pulse widths than are conventional in typical SCS stimulation therapies. This results in determined stimulation therapies which draw very little power. Therapy is preferably provided by the use of symmetric biphasic pulses.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

This document discusses a neurostimulation device. The neurostimulation device includes a stimulation circuit; a sensing circuit to sense evoked synaptic activity potential (ESAP) signals when coupled to the implantable lead, and a control circuit. The control circuit is configured to initiate delivery of neurostimulation energy by the stimulation circuit, initiate sensing by the sensing circuit of ESAP signals produced by the delivery of neurostimulation energy, change at least one parameter of the neurostimulation energy and continue the sensing of the ESAP signals, compare the sensed ESAP signals to a stored best sensed ESAP signal, wherein the best sensed ESAP signal was previously sensed at a recorded anatomical location using a different trial lead, and determine neurostimulation therapy parameters including a neurostimulation location to produce a best match ESAP signal at the recorded anatomical location that is a closest match to the stored best sensed ESAP signals.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

A system for stimulation of a nucleus basalis of Meynert (NBM) of a patient includes an implantable electrical stimulation lead including electrodes and configured for implantation of at least one of the electrodes adjacent to or within the NBM of the patient; and an implantable pulse generator coupleable to the implantable electrical stimulation lead and configured for delivering electrical stimulation to the NBM through at least one of the electrodes of the implantable electrical stimulation lead, the implantable pulse generator including at least one processor configured to, upon user request, during an initial stimulation period, which is at least 1 month in duration and has a start and an end, increase over time at least one of a duration or an amplitude of the electrical stimulation from an initial value at the start of the initial stimulation period to a final value at the end of the initial stimulation period.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

Algorithms for determining optimal low-frequency and sub-perception spinal cord stimulation for a patient are disclosed. A spread bipole is preferably used both to position the stimulation to target a patient's pain, and to provide the resulting therapy. The stimulation is provided at very low frequencies, such as 10 Hz or less, and preferably 2 Hz. Further, sub-perception is provided by the use of lower amplitudes and at longer pulse widths than are conventional in typical SCS stimulation therapies. This results in determined stimulation therapies which draw very little power. Therapy is preferably provided by the use of symmetric biphasic pulses.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/37 - SurveillanceProtection
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

Radiofrequency ablation systems having a user interface. Pre-therapy planning and testing is performed and data gathered by the radiofrequency ablation system. A user interface for the radiofrequency ablation system displays anatomical mapping locations that have been tested, with indicia of testing outcomes including positive and negative outcome information and the type of testing performed.

Classes IPC  ?

• A61B 34/00 - Chirurgie assistée par ordinateurManipulateurs ou robots spécialement adaptés à l’utilisation en chirurgie
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 18/12 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci par chauffage en faisant passer des courants à travers les tissus à chauffer, p. ex. des courants à haute fréquence
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci
• A61B 90/00 - Instruments, outillage ou accessoires spécialement adaptés à la chirurgie ou au diagnostic non couverts par l'un des groupes , p. ex. pour le traitement de la luxation ou pour la protection de bords de blessures

Abrégé

Radiofrequency ablation systems having a user interface. Pre-therapy planning and testing is performed and data gathered by the radiofrequency ablation system. A user interface for the radiofrequency ablation system displays anatomical mapping locations that have been tested, with indicia of testing outcomes including positive and negative outcome information and the type of testing performed.

Classes IPC  ?

• A61B 18/14 - Sondes ou électrodes à cet effet
• A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
• A61B 18/00 - Instruments, dispositifs ou procédés chirurgicaux pour transférer des formes non mécaniques d'énergie vers le corps ou à partir de celui-ci

Abrégé

Systems and methods for adaptive neuromodulation based on evoked responses are disclosed. An exemplary system comprises at least one lead, an electrostimulator to provide electrostimulation to a neural target, a sensing circuit to sense ERs to electrostimulation, and a controller circuit. In response to electrostimulation delivered to the neural target in accordance with a stimulation setting via a stimulating electrode, the controller circuit can collect sensed ERs to the electrostimulation using at least one sensing electrode on the at least one lead and determine a first stimulation threshold for a stimulation parameter based on a first sensed threshold of the collected sensed ERs. The first stimulation threshold can be a stimulation value at which a change in the collected sensed ERs occurs.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque

Abrégé

Methods, system, and computer-implementable algorithms are disclosed for determining time-varying pulses for a patient having an implantable stimulator device (ISD). At least one time-invariant tonic stimulation pulse parameter (e.g., amplitude, pulse width, or frequency) is modified by a modulation function to produce time-varying pulses (TVPs), and one or more measurements are taken to determine the effectiveness of the TVP. The measurements may be objective and taken from the patient, and/or subjective and determined based on feedback from the patient. In one example, objective measurements may comprise one or more features determined from an electrospinogram (ESG) signal detected by the ISD, which may include evoked compound action potentials. The one or more measurements are used to determine a score for the TVP, which is useful in selecting a best TVP for use with the patient, or for adjusting the modulation function applied to the tonic stimulation parameters.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for generating, testing, and evaluating therapy programs for use in neuromodulation. Test programs are generated using paresthesia and/or anatomical considerations. As test programs are applied to the patient, the test programs are evaluated using patient feedback and grading of locations in relation to active therapy delivery electrodes of the system.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

An implantable lead including a lead body, an electrode disposed along the distal end of the lead body, and a dummy contact disposed along the lead body. A terminal electrode contact is disposed along the proximal end of the lead body and is coupled to the electrode via a conductive wire, and a conductive dummy wire is couple to the dummy contact but is free of connection to any terminal electrode contact. The conductive dummy wire may connect to a dummy terminal adapted to be coupled to a pulse generator housing via a high pass filter or a switch.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
• A61N 1/37 - SurveillanceProtection

Abrégé

Methods and systems for reprogramming an implantable medical device. A reprogramming mode may be initiated in an application running on a patient remote control. In the reprogramming mode, one or more trial programs may be displayed on a user interface. The one or more trial programs may be displayed in response to receiving an initial patient efficacy rating below a predetermined threshold. The one or more trial programs may be calibrated. The implantable medical device may be successively operated in accordance with the parameters of each trial program. A patient efficacy rating may determine if any of the trial programs meet a predetermined acceptable pain management standard.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for adapting a neuromodulation system to changes in system integrity. A system may check system integrity in response to the passage of time or to an asynchronous trigger. If a loss of system integrity is identified, changes to therapy program parameters are determined and tested for satisfactory performance. The changes to a therapy program may include identifying a new therapeutic target. Physician approval of the change process, as well as final program parameters, is contemplated.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

An implantable lead including a lead body, an electrode disposed along the distal end of the lead body, and a dummy contact disposed along the lead body. A terminal electrode contact is disposed along the proximal end of the lead body and is coupled to the electrode via a conductive wire, and a conductive dummy wire is couple to the dummy contact but is free of connection to any terminal electrode contact. The conductive dummy wire may connect to a dummy terminal adapted to be coupled to a pulse generator housing via a high pass filter or a switch.

Classes IPC  ?

• A61N 1/08 - Aménagements ou circuits de surveillance, de protection, de commande ou d'indication
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/375 - Aménagements structurels, p. ex. boîtiers

Abrégé

Methods and systems for reprogramming an implantable medical device. A reprogramming mode may be initiated in an application running on a patient remote control. In the reprogramming mode, one or more trial programs may be displayed on a user interface. The one or more trial programs may be displayed in response to receiving an initial patient efficacy rating below a predetermined threshold. The one or more trial programs may be calibrated. The implantable medical device may be successively operated in accordance with the parameters of each trial program. A patient efficacy rating may determine if any of the trial programs meet a predetermined acceptable pain management standard.

Classes IPC  ?

• G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local

Abrégé

Methods and systems for adapting a neuromodulation system to changes in system integrity. A system may check system integrity in response to the passage of time or to an asynchronous trigger. If a loss of system integrity is identified, changes to therapy program parameters are determined and tested for satisfactory performance. The changes to a therapy program may include identifying a new therapeutic target. Physician approval of the change process, as well as final program parameters, is contemplated.

Classes IPC  ?

• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

This document discusses systems, devices, and methods for computer-assisted pain or paresthesia assessment and pain management in a subject. A system includes a programming aid device including a user interface, a transceiver circuit to receive information about pain management for the patient from one or more of a software- based virtual agent (SVA) or a human assistant other than the patient, and a controller circuit to initiate and manage information exchange session between the patient and one or more of the SVA or the human assistant, via the user interface, regarding pain or paresthesia sensation and pain management. Based on the information exchange, the controller determines a stimulation setting, and generate a therapy control signal to the neuromodulation device to initiate delivery of neuromodulation energy according to the determined stimulation setting.

Classes IPC  ?

• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Methods and systems for generating, testing, and evaluating therapy programs for use in neuromodulation. Test programs are generated using paresthesia and/or anatomical considerations. As test programs are applied to the patient, the test programs are evaluated using patient feedback and grading of locations in relation to active therapy delivery electrodes of the system.

Classes IPC  ?

• G16H 20/40 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mécaniques, la radiothérapie ou des thérapies invasives, p. ex. la chirurgie, la thérapie laser, la dialyse ou l’acuponcture
• A61N 1/02 - ÉlectrothérapieCircuits à cet effet Parties constitutives
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
• G16H 40/60 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux
• G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne

Abrégé

An optical stimulation lead includes a lead body including a distal end, a distal portion, and a proximal portion; and an optical assembly attached to the distal end of the lead body. The optical assembly includes a metal enclosure; a light emitter disposed within the metal enclosure; an electrical feedthrough pin electrically coupled to the light emitter; a first substrate disposed within the metal enclosure; and an emitter cover disposed opposite the lead body, configured to transmit light from the light emitter, and coupled to the metal enclosure. The first substrate includes aluminum nitride and the first substrate is arranged within the metal enclosure with the aluminum nitride in a thermal conductive path that conducts heat from the light emitter to the metal enclosure.

Classes IPC  ?

• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
• A61N 5/067 - Thérapie par radiations utilisant un rayonnement lumineux utilisant un rayonnement laser

Abrégé

Methods and systems for delivering a therapy and observing one or more metrics of autonomic function. Spinal cord stimulation may be initiated, and patient response monitored using one or more metrics of autonomic function, including heart rate, heart rate variability, or other markers. Therapy intensity may be increased or decreased, or therapy may be changed to use a different program, or therapy may be ceased, depending on changes in the observed metrics of autonomic function.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus

Abrégé

Systems and techniques are disclosed for determining and implementing neurostimulation programming, based on sensing and therapy capabilities. An example technique includes: identifying an arrangement for a plurality of electrical contacts of one or more implanted leads; identifying neurostimulation parameters for delivering therapy to a neurostimulation location using a first set of electrical contacts of the arrangement; determining a sensing capability for sensing an evoked response to the therapy delivered to the neurostimulation location, using a second set of electrical contacts of the arrangement, and determining the sensing capability based on the arrangement and the neurostimulation parameters; and changing at least a portion of the neurostimulation parameters for delivering the therapy, in response to a determination that the sensing capability is not available at the neurostimulation location. The changed neurostimulation parameters can be programmed and used for delivering therapy to a changed neurostimulation location that provides suitable sensing capabilities.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for delivering a therapy and observing one or more metrics of autonomic function. Spinal cord stimulation may be initiated, and patient response monitored using one or more metrics of autonomic function, including heart rate, heart rate variability, or other markers. Therapy intensity may be increased or decreased, or therapy may be changed to use a different program, or therapy may be ceased, depending on changes in the observed metrics of autonomic function.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A method for photobiomodulation includes emitting light from a lead implanted in a patient using a light source according to a first delivery program to photobiomodulate the patient; monitoring at least one biomarker, an evoked signal, or a local field potential to monitor at least one effect of the photobiomodulation; determining, by a processor, whether the monitoring of the at least one biomarker meets a change condition; when the monitoring of the at least one biomarker meets a change condition, determining, by the processor, a change to the first delivery program to produce a second delivery program; and emitting light from the implanted lead according to the second delivery program. Other aspects include coordinated photobiomodulation and electrical stimulation.

Classes IPC  ?

• A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

Methods and systems for optimizing and/or maintaining stimulation during deep brain stimulation (DBS) are described. The methods and systems involve determining evoked neural responses, namely evoked resonant neural activity (ERNA) evoked in a patient's brain by the stimulation. ERNA features corresponding to the patient's brain state during the absence and during the presence of therapeutic stimulation are determined. The ERNA features are used to guide and to maintain stimulation parameters for therapeutic stimulation.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Systems and techniques are disclosed for determining and implementing neurostimulation programming, based on sensing and therapy capabilities. An example technique includes: identifying an arrangement for a plurality of electrical contacts of one or more implanted leads; identifying neurostimulation parameters for delivering therapy to a neurostimulation location using a first set of electrical contacts of the arrangement; determining a sensing capability for sensing an evoked response to the therapy delivered to the neurostimulation location, using a second set of electrical contacts of the arrangement, and determining the sensing capability based on the arrangement and the neurostimulation parameters; and changing at least a portion of the neurostimulation parameters for delivering the therapy, in response to a determination that the sensing capability is not available at the neurostimulation location. The changed neurostimulation parameters can be programmed and used for delivering therapy to a changed neurostimulation location that provides suitable sensing capabilities.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
• A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs

Abrégé

Methods and systems for planning configurations of a neuromodulation system having a lead with a plurality of electrodes. Configurations are planned using an optimizer that analyzes potential fractionalizations after removing unavailable electrodes from analysis and adjusting a candidate fractionalization to account for the removed electrodes. The unavailable electrodes may be identified by a physician or by analysis of impedances of the electrodes.

Classes IPC  ?

• A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques

Abrégé

A burr hole plug includes a plug base defining a plurality of grooves and a burr hole aperture for insertion of at least one lead (or multiple leads) through the plug base, wherein each of the grooves is configured for receiving a portion of a lead, wherein each of the grooves is defined by at least one groove wall, wherein, for each of the grooves, the plug base further includes at least one grip extending into the groove from the at least one groove wall to engage, and facilitate retention of, the portion of any lead received within the groove; and a cover configured to be disposed over, and removably coupled to, the plug base for lead retention. Alternatively or additionally, a burr hole plug can include one or more of a solid filler disposed in the burr hole aperture or a clip ring for lead retention.

Classes IPC  ?

• A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque