Abrégé

The invention relates to improved processes for lyophilising bacterial products which minimise the loss of viable cells during the lyophilisation process, enabling the products to be lyophilised in an efficient and economic manner. The lyophilisation process of the invention achieves improved viability of the lyophilised cells.

Classes IPC  ?

• F26B 5/06 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide le procédé impliquant la congélation
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Abrégé

A computer-implemented method for stratifying a patient with irritable bowel syndrome (IBS). The method comprises detecting the presence,absence, or abundance of multiple bacteria in a biological sample obtained from the patient to generate a patient microbiome profile; and operating a trained classifier on the patient microbiome profile to output a signal stratifyingthe patient with irritable bowel syndrome (IBS) into a first group or a second group. Stratification of the patient into the first group is indicative that the patient has a not significantly altered microbiome in comparison to the averagemicrobiome not indicative of IBS. Stratification of the patient into the second group is indicative that the patient has an altered microbiome in comparison to the averagemicrobiome not indicative of IBS. Figure4to be published with the abstract.

Classes IPC  ?

• G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients

Produits et services

Pharmaceuticals; pharmaceuticals as live biotherapeutics; live biotherapeutic bacterial formulations for medical use; preparations of microorganisms for medical use.

Produits et services

Pharmaceuticals; pharmaceuticals as live biotherapeutics; live biotherapeutic bacterial formulations for medical use; preparations of microorganisms for medical use.

Abrégé

Provided are compositions comprising a bacterial strain of the genus Blautia, for use in a method of increasing the microbiota diversity and/or inducing stability of the microbiota of a subject.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A61P 1/14 - Eupeptiques, p. ex. acides, enzymes, orexigènes, antidyspeptiques, toniques, antiflatulants
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Produits et services

Pharmaceuticals, namely, live biotherapeutics for the treatment of irritable bowel syndrome (IBS) and intestinal disorders; live biotherapeutic bacterial formulations for medical use, namely, the treatment of irritable bowel syndrome (IBS) and intestinal disorders; preparations of microorganisms for medical use

Produits et services

Pharmaceuticals, namely, live biotherapeutics for the treatment of Crohn's disease and bowel diseases; live biotherapeutic bacterial formulations for medical use, namely, the treatment of Crohn's disease and bowel diseases; preparations of microorganisms for medical use

Produits et services

(1) Pharmaceuticals and pharmaceuticals as live biotherapeutics for the treatment of brain injuries, namely strokes and ischemic events, central nervous system disorders, namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease, cancer, bowel disorders, namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis, lung disorders and diseases, namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome, inflammatory diseases, namely arthritis and autoimmune diseases; Live biotherapeutics and live biotherapeutic bacterial formulations for the treatment of brain injuries, namely strokes and ischemic events, central nervous system disorders, namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease, cancer, bowel disorders, namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis, lung disorders and diseases, namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome, inflammatory diseases, namely arthritis and autoimmune diseases; Preparations of microorganisms for the treatment of brain injuries, namely strokes and ischemic events, central nervous system disorders, namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease, cancer, bowel disorders, namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis, lung disorders and diseases, namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome, inflammatory diseases, namely arthritis and autoimmune diseases

Produits et services

(1) Pharmaceuticals and pharmaceuticals as live biotherapeutics for the treatment of brain injuries, namely strokes and ischemic events, central nervous system disorders, namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease, cancer, bowel disorders, namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis, lung disorders and diseases, namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome, inflammatory diseases, namely arthritis and autoimmune diseases; Live biotherapeutics and live biotherapeutic bacterial formulations for the treatment of brain injuries, namely strokes and ischemic events, central nervous system disorders, namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease, cancer, bowel disorders, namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis, lung disorders and diseases, namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome, inflammatory diseases, namely arthritis and autoimmune diseases; Preparations of microorganisms for the treatment of brain injuries, namely strokes and ischemic events, central nervous system disorders, namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease, cancer, bowel disorders, namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis, lung disorders and diseases, namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome, inflammatory diseases, namely arthritis and autoimmune diseases

Produits et services

(1) Chemicals for use as pharmaceuticals; chemicals used in the manufacture of pharmaceuticals; raw proteins for use in pharmaceuticals. (2) Pharmaceuticals and pharmaceuticals as live biotherapeutics for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases; Live biotherapeutics and live biotherapeutic bacterial formulations for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases; Preparations of microorganisms for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases. (1) Scientific research and development services in the field of pharmaceuticals, pharmaceuticals as live biotherapeutics, live biotherapeutics, live biotherapeutic bacterial formulations and preparations of microorganisms for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases; microbiology research and development into live biotherapeutics.

Produits et services

Pharmaceuticals; pharmaceuticals as live biotherapeutics; live biotherapeutic bacterial formulations for medical use; preparations of microorganisms for medical use.

Produits et services

Pharmaceuticals, namely, live biotherapeutics for the treatment of cancer, brain injuries, central nervous system disorders, bowel disorders, lung disorders and diseases, and inflammatory and autoimmune diseases; live biotherapeutic bacterial formulations for medical use, namely, the treatment of cancer, brain injuries, central nervous system disorders, bowel disorders, lung disorders and diseases, and inflammatory and autoimmune diseases; preparations of microorganisms for medical use

Produits et services

(1) Pharmaceutical preparations for the treatment of depression, cancer, bacterial infections, namely bacterial intestinal infections and Clostridium difficile infections, vaccine adjuvancy, lung injury and asthma; pharmaceutical preparations for the treatment of autoimmune diseases and inflammatory diseases, namely inflammatory bowel diseases and inflammatory connective tissue diseases; pharmaceutical preparations for the treatment of neurological diseases and neurodegenerative diseases, namely Parkinson's, Alzheimer's, Huntington's Disease and cerebral palsy; pharmaceutical preparations for the treatment of central nervous system disorders, namely autism, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders and spinal cord diseases; pharmaceutical preparations for the treatment of brain injury; pharmaceutical preparations for the treatment of autoimmune disorders of the central nervous system and inflammatory disorders of the central nervous system; pharmaceutical preparations for the treatment of diarrhoea, constipation and sensory hypersensitivity; and pharmaceutical preparations for the treatment of gastro-intestinal diseases; pharmaceutical preparations as live biotherapeutics for the treatment of depression, cancer, bacterial infections, namely bacterial intestinal infections and Clostridium difficile infections, vaccine adjuvancy, lung injury and asthma; pharmaceutical preparations as live biotherapeutics for the treatment of autoimmune diseases and inflammatory diseases, namely inflammatory bowel diseases and inflammatory connective tissue diseases; pharmaceutical preparations as live biotherapeutics for the treatment of neurological diseases and neurodegenerative diseases, namely Parkinson's, Alzheimer's, Huntington's Disease and cerebral palsy; pharmaceutical preparations as live biotherapeutics for the treatment of central nervous system disorders, namely autism, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders and spinal cord diseases; pharmaceutical preparations as live biotherapeutics for the treatment of brain injury; pharmaceutical preparations as live biotherapeutics for the treatment of autoimmune disorders of the central nervous system and inflammatory disorders of the central nervous system; pharmaceutical preparations as live biotherapeutics for the treatment of diarrhoea, constipation and sensory hypersensitivity; and pharmaceutical preparations as live biotherapeutics for the treatment of gastro-intestinal diseases; live biotherapeutic bacterial formulations for the treatment of depression, cancer, bacterial infections, namely bacterial intestinal infections and Clostridium difficile infections, vaccine adjuvancy, lung injury and asthma; live biotherapeutic bacterial formulations for the treatment of autoimmune diseases and inflammatory diseases, namely inflammatory bowel diseases and inflammatory connective tissue diseases; live biotherapeutic bacterial formulations for the treatment of neurological diseases and neurodegenerative diseases, namely Parkinson's, Alzheimer's, Huntington's Disease and cerebral palsy; live biotherapeutic bacterial formulations for the treatment of central nervous system disorders, namely autism, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders and spinal cord diseases; live biotherapeutic bacterial formulations for the treatment of brain injury; live biotherapeutic bacterial formulations for the treatment of autoimmune disorders of the central nervous system and inflammatory disorders of the central nervous system; live biotherapeutic bacterial formulations for the treatment of diarrhoea, constipation and sensory hypersensitivity; and live biotherapeutic bacterial formulations for the treatment of gastro-intestinal diseases; preparations of microorganisms for the treatment of depression, cancer, bacterial infections, namely bacterial intestinal infections and Clostridium difficile infections, vaccine adjuvancy, lung injury and asthma; preparations of microorganisms for the treatment of autoimmune diseases and inflammatory diseases, namely inflammatory bowel diseases and inflammatory connective tissue diseases; preparations of microorganisms for the treatment of neurological diseases and neurodegenerative diseases, namely Parkinson's, Alzheimer's, Huntington's Disease and cerebral palsy; preparations of microorganisms for the treatment of central nervous system disorders, namely autism, central nervous system infections, brain diseases, central nervous system movement disorders, ocular motility disorders and spinal cord diseases; preparations of microorganisms for the treatment of brain injury; preparations of microorganisms for the treatment of autoimmune disorders of the central nervous system and inflammatory disorders of the central nervous system; preparations of microorganisms for the treatment of diarrhoea, constipation and sensory hypersensitivity; and preparations of microorganisms for the treatment of gastro-intestinal diseases

Produits et services

Pharmaceuticals; pharmaceuticals as live biotherapeutics; live biotherapeutic bacterial formulations for medical use; preparations of microorganisms for medical use.

Abrégé

The invention provides compositions comprising one or more bacterial strains for use in a method of reducing the level of Enterobacteriaceae in the gastrointestinal tract.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Abrégé

The invention provides compositions comprising one or more bacterial strains for treating preventing diarrhea and/or constipation.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées

Abrégé

The invention provides compositions comprising one or more bacterial strains for treating or preventing visceral hypersensitivity.

Classes IPC  ?

• A61K 35/741 - Probiotiques
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 1/14 - Eupeptiques, p. ex. acides, enzymes, orexigènes, antidyspeptiques, toniques, antiflatulants
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Produits et services

(1) Chemicals for use as pharmaceuticals; chemicals used in the manufacture of pharmaceuticals; raw proteins for use as pharmaceuticals; raw proteins used in the manufacture of pharmaceuticals (2) Pharmaceuticals and pharmaceuticals as live biotherapeutics for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases; Live biotherapeutics and live biotherapeutic bacterial formulations for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases; Preparations of microorganisms for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases (1) Scientific research and development services in the field of pharmaceuticals, pharmaceuticals as live biotherapeutics, live biotherapeutics, live biotherapeutic bacterial formulations and preparations of microorganisms for the treatment of brain injuries (namely strokes and ischemic events), central nervous system disorders (namely, multiple sclerosis, autism, obsessive compulsive disorder, depression, anxiety and neurodegenerative disorders, namely Parkinson's disease and Alzheimer's Disease), cancer, bowel disorders (namely, visceral hypersensitivity, diarrhea, constipation, bacterial infections, dysbiosis, irritable bowel syndrome and inflammatory bowel disorders, namely Crohn's disease and ulcerative colitis), lung disorders and diseases (namely, asthma, chronic obstructive pulmonary disease and acute respiratory distress syndrome), inflammatory diseases (namely arthritis) and autoimmune diseases; microbiology research and development into live biotherapeutics

Produits et services

(1) Scientific research and development services in the field of microbiology, biotechnology, and live biotherapeutics; microbiology research and development into live biotherapeutics

Produits et services

(1) Scientific research and development services in the field of microbiology, biotechnology, and live biotherapeutics; microbiology research and development into live biotherapeutics

Produits et services

Chemicals; chemicals used in the manufacture of pharmaceuticals; raw proteins. Pharmaceuticals; pharmaceuticals as live biotherapeutics; live biotherapeutics for the treatment of inflammatory and autoimmune diseases; live biotherapeutic bacterial formulations for medical use; preparations of microorganisms for medical use. Scientific research and development; microbiology research and development into live biotherapeutics.