Abrégé

A method for synthesizing (R)-(−)-1-((S)-2-diphosphino ferrocene)-ethyl-diphosphine by: 1) adding vinylferrocene, a chiral catalyst, and toluene to a first drying reactor; adding a phosphorus-hydrogen compound to the first drying reactor and allowing reactants in the first drying reactor to react; cooling the first drying reactor; adding water dropwise to the first drying reactor; extracting, drying, and recrystallizing a product to yield (R)-1-ferrocenylethyl-diphosphine; 2) adding the (R)-1-ferrocenylethyl-diphosphine and ether to a second drying reactor; adding a hexane solution including diethylzinc to the second drying reactor and allowing reactants in the second drying reactor to react; adding a phosphorus-chlorine compound dropwise to the second drying reactor, and heating and refluxing the reaction mixture in the second drying reactor; adding water to quench the reaction mixture in the second drying reactor; and extracting, drying, and recrystallizing the reaction mixture.

Classes IPC  ?

• B01J 31/22 - Complexes organiques
• C08F 4/6192 - Composant couvert par le groupe contenant une liaison métal de transition-carbone contenant au moins un cycle cyclopentadiényle, condensé ou non, p. ex. un cycle indényle ou fluorényle
• B01J 31/02 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques
• C07F 15/02 - Composés du fer
• C07F 9/12 - Esters des acides phosphoriques avec des composés hydroxyarylés
• G01R 33/46 - Spectroscopie RMN

Abrégé

The present invention discloses a method for synthesizing a chiral ferrocene-like P, P ligand, and belongs to the technical field of organic synthesis. The method is implemented through the following steps: (1) using vinyl ferrocene as a starting material to react with a phosphine hydrogen compound in the presence of chiral catalyst to obtain ( R)-1-ferrocenyl ethyl diphosphine; and (2) after ( R)-1-ferrocenyl ethyl diphosphine reacts with diethylzinc, further reacting with a phosphine chloride compound to obtain a chiral ferrocene-like P, P ligand ( R)-(-)-1-[( S)-2-diphosphinyl ferrocene] ethyl diphosphine. Compared with the prior art, the present invention involves fewer steps, and is simple in operation and high in yield and thus is more suitable for industrial production. The prepared chiral ferrocene-like P, P compound can be used as a ligand of a metal catalyst in fields such as pharmaceutical synthesis.

Classes IPC  ?

• C07F 17/02 - Metallocènes de métaux des groupes 8, 9 ou 10 du tableau périodique
• C07B 53/00 - Synthèses asymétriques