A particulate dispensing apparatus for dispensing a plurality of quantities of a particulate material separately and simultaneously, having a feed carriage with flow-through feed ports to retain bulk particulate, a fill carriage comprising a fill plate having a plurality of flow-through fill holes having a volume to receive and retain the particulate from the feed ports, and a dispensing carriage having flow-through dispensing ports movable below the fill carriage between a position block discharge of particulate from the fill holes, and a position that aligns with the fill holes dispensing the particulate. A volume adjusting element is adjustably positionable within each fill hole to adjust the retaining volume within the associated fill hole for the particulate, for making adjustments in the quantity of particulate dispensed from each fill hole without changing the fill plate.
A binder jet printing system that uses one or more process analytical techniques in the processing of articles. The system has one or more fabrication substrate with one or more formation surfaces, an article forming system having a depositing device for placing a construction material onto the one or more formation surfaces when the fabrication substrate is positioned at a deposition position, and a processing device for performing a process unit operation on the construction material when the fabrication substrate is disposed at a processing position; a movement controller to control transporting of the one or more fabrication substrates between the deposition position and the processing position for forming the article; and one or more process analytical technologies for monitoring, scanning or detecting one or more physical or chemical properties of an article, an intermediate product, or an ingredient used in the manufacturing of the articles.
B29C 64/393 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/20 - Appareil pour la fabrication additiveDétails ou accessoires à cet effet
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
A61J 3/10 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de tablettes comprimées
B41F 17/36 - Appareils ou machines à imprimer de type particulier ou pour emploi particulier, non prévus ailleurs pour l'impression des pastilles, pilules ou petits objets similaires
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, compounds in a unitary solid dosage form made by a three-dimensional printing process for the rapid dispersion of a wide variety of therapeutic agents Pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others; research and development in the pharmaceutical and nutraceutical fields for others; Consulting services in the field of biotechnology in the development of pharmaceutical and nutraceutical preparations in the nature of drug delivery systems Medical and pharmaceutical consultancy, namely, pharmaceutical advice about drug delivery systems
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, compounds in a unitary solid dosage form made by a three-dimensional printing process for the rapid dispersion of a wide variety of therapeutic agents Pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others; research and development in the pharmaceutical and nutraceutical fields for others; Consulting services in the field of biotechnology in the development of pharmaceutical and nutraceutical preparations in the nature of drug delivery systems Medical and pharmaceutical consultancy, namely, pharmaceutical advice about drug delivery systems
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparations, namely, compounds in a unitary solid dosage form made by a three-dimensional printing process for the rapid dispersion of a wide variety of therapeutic agents Pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others; research and development in the pharmaceutical and nutraceutical fields for others; Consulting services in the field of biotechnology in the development of pharmaceutical and nutraceutical preparations in the nature of drug delivery systems Medical and pharmaceutical consultancy, namely, pharmaceutical advice about drug delivery systems
6.
SYSTEM AND METHOD FOR ADDITIVE MANUFACTURING USING AN OMNIDIRECTIONAL MAGNETIC MOVEMENT APPARATUS
A process system and method for the making of articles, using an omnidirectional magnetic movement system with a transport surface and fabrication modules having a formation surface that can be transported omnidirectionally over the transport surface under the control of a movement controller. An article forming system provides process unit operations for forming articles onto the formation surface as the fabrication modules are moved asynchronously between a plurality of processing positions on the transport surface, and features a depositing device for placing a construction material onto the formation surface and one or more processing devices to form the construction material into the article.
A rapidly-orodispersible tablet containing a porous, bound powder matrix containing droxidopa. The bound matrix contains an acidulant, particularly citric acid, to delay, reduce, or inhibit the coloration of droxidopa during stress storage conditions, and suppress the effect of glycerin on the coloration of droxidopa-containing tablets. The tablet can be dividable along a functional seam printed into the bound powder matrix, to divide the tablet into sub-dosage units of the same mass of droxidopa.
A dividable tablet with a functional seam for functionally dividing the dividable tablet into substantially equivalent sub-dosage units along the functional seam. The functional seam is configured to subdivide the sub-dosage units into the same mass within a tolerance of about 3% or less, and typically of 1.0% or less. The functional seam is configured reduce the amount of lost material that separates from the divided sub-dosage units after divi sion of the dividable tablet along the functional seam, to less than 3%, and typically less than 1.0%, and more typically less than 0.1% of the mass of the undivided dividable tablet.
A61J 3/00 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations, namely, drug delivery agents consisting of unitary or assembled multi-piece solid dosage forms that facilitate the rapid dispersion of a wide variety of therapeutic agents; drug delivery agents in the form of separate dosage form pieces for subsequent filling and assembly into unitary solid dosage forms that facilitate the rapid dispersion of a wide variety of therapeutic agents
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, a drug delivery system consisting of a multilayered tablet which can be tailored to individual patient needs by providing various functionalities, precision dosing of one or more APIs, and/or enhanced bioavailability for poorly soluble compounds through flexible compositions, unique designs, and different routes of oral administration routes pharmaceutical manufacturing services to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others, namely, pharmaceutical and nutraceutical compounds in a multilayered tablet form for the rapid dispersion of a wide variety of therapeutic agents; research and development in the pharmaceutical and nutraceutical fields for others, namely, research and development of pharmaceutical and nutraceutical compounds in a multilayered tablet form for the rapid dispersion of a wide variety of therapeutic agents
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, a drug delivery system consisting of compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents Pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others, namely, pharmaceutical and nutraceutical compounds for the precision dosing, embedded functionality, rapid dispersion and flexible routes of administration of a wide variety of therapeutic agents; research and development in the pharmaceutical and nutraceutical fields for others, namely, research and development of pharmaceutical and nutraceutical compounds for the precision dosing, embedded functionality, rapid dispersion and flexible routes of administration of a wide variety of therapeutic agents
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, a drug delivery system consisting of a multilayered tablet which can be tailored to individual patient needs by providing various functionalities, precision dosing of one or more APIs, and/or enhanced bioavailability for poorly soluble compounds through flexible composition designs and administration routes Pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others, namely, pharmaceutical and nutraceutical compounds for the precision dosing, embedded functionality, rapid dispersion and flexible routes of administration of a wide variety of therapeutic agents; research and development in the pharmaceutical and nutraceutical fields for others, namely, research and development of pharmaceutical and nutraceutical compounds for the precision dosing, embedded functionality, rapid dispersion and flexible routes of administration of a wide variety of therapeutic agents
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, a drug delivery system consisting of a multilayered tablet which can be tailored to individual patient needs by providing various functionalities, precision dosing of one or more APIs, and/or enhanced bioavailability for poorly soluble compounds through flexible compositions, unique designs, and different routes of oral administration routes Pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others, namely, pharmaceutical and nutraceutical compounds in a multilayered tablet form for the rapid dispersion of a wide variety of therapeutic agents; research and development in the pharmaceutical and nutraceutical fields for others, namely, research and development of pharmaceutical and nutraceutical compounds in a multilayered tablet form for the rapid dispersion of a wide variety of therapeutic agents
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, compounds in a unitary solid dosage form made by a three-dimensional printing process for the rapid dispersion of a wide variety of therapeutic agents Pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others; research and development in the pharmaceutical and nutraceutical fields for others
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Development of pharmaceutical and nutraceutical preparations for others, namely, pharmaceutical and nutraceutical compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents; research and development in the pharmaceutical and nutraceutical fields for others, namely, research and development of pharmaceutical and nutraceutical compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Pharmaceutical preparations, namely, a drug delivery system consisting of compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents Pharmaceutical manufacturing to the order and/or specification of others
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, a drug delivery system consisting of compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents pharmaceutical manufacturing to the order and/or specification of others Development of pharmaceutical and nutraceutical preparations for others, namely, pharmaceutical and nutraceutical compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents; research and development in the pharmaceutical and nutraceutical fields for others, namely, research and development of pharmaceutical and nutraceutical compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents
18.
SYSTEM AND METHOD FOR ADDITIVE MANUFACTURING USING AN OMNIDIRECTIONAL MAGNETIC MOVEMENT APPARATUS
A process system and method for the making of articles, using an omnidirectional magnetic movement system (20) with a transport surface and fabrication modules having a formation surface that can be transported omnidirectionally over the transport surface under the control of a movement controller. An article forming system provides process unit operations for forming articles onto the formation surface as the fabrication modules are moved asynchronously between a plurality of processing positions on the transport surface, and features a depositing device (40) for placing a construction material onto the formation surface and one or more processing devices (50,60) to form the construction material into the article.
A rapidly-orodispersible dosage form comprising a porous, bound-powder matrix and one or more internal cavities is provided, as well as three-dimensional printing methods for making the same. Each internal cavity is configured to contain one or more payloads, particularly pharmaceutical medicaments, while isolating the payloads from the external environment outside of the dosage form. Each payload can be contained within its cavity in its native form without having to be combined with the bound-powder matrix or binding liquid. Dosage forms can disintegrate in water or saliva in less than two minutes, independently of the payload(s) or medicament(s) contained within. The dosage forms can be formed as unitary tablets, or as two-piece tablets comprising a container body and a lidding body that are secured together to isolate the one or more cavities and their payloads inside.
A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted powder layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.
A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of water soluble drug in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to the drug.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
B29C 64/00 - Fabrication additive, c.-à-d. fabrication d’objets en trois dimensions [3D] par dépôt additif, agglomération additive ou stratification additive, p. ex. par impression en 3D, stéréolithographie ou frittage laser sélectif
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
B28B 11/06 - Appareillages ou procédés pour le traitement ou le travail des objets façonnés pour le revêtement avec des matériaux en poudre ou granulés
B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p. ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
B29C 64/176 - Procédés de fabrication additive spécialement adaptés à la fabrication d'objets multiples en 3D successivement
B29C 64/188 - Procédés de fabrication additive impliquant des opérations supplémentaires effectuées sur les couches ajoutées, p. ex. lissage, meulage ou contrôle d’épaisseur
B29C 64/241 - Moyens d’entraînement pour mouvement rotatif
B29C 64/30 - Opérations ou équipements auxiliaires
B29C 64/379 - Manutention des objets en 3D obtenus, p. ex. à l’aide de robots
B30B 11/08 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage coopérant avec des moules portés par une table tournante
A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of water soluble drug in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to the drug.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer, Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.
A61J 1/03 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour pilules ou comprimés
A61J 3/06 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de pilules, tablettes ou pastilles
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
25.
Three-dimensional printing system and equipment assembly
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
B29C 64/236 - Moyens d’entraînement pour un mouvement dans une direction dans le plan d’une couche
B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p. ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
B33Y 40/20 - Posttraitement, p. ex. durcissement, revêtement ou polissage
A rapidly-orodispersible dosage form comprising a porous, bound-powder matrix and one or more internal cavities is provided, as well as three-dimensional printing methods for making the same. Each internal cavity is configured to contain one or more payloads, particularly pharmaceutical medicaments, while isolating the payloads from the external environment outside of the dosage form. Each payload can be contained within its cavity in its native form without having to be combined with the bound-powder matrix or binding liquid. Dosage forms can disintegrate in water or saliva in less than two minutes, independently of the payload(s) or medicament(s) contained within. The dosage forms can be formed as unitary tablets, or as two-piece tablets comprising a container body and a lidding body that are secured together to isolate the one or more cavities and their payloads inside.
A rapidly-orodispersible dosage form comprising a porous, bound-powder matrix and one or more internal cavities is provided, as well as three-dimensional printing methods for making the same. Each internal cavity is configured to contain one or more payloads, particularly pharmaceutical medicaments, while isolating the payloads from the external environment outside of the dosage form. Each payload can be contained within its cavity in its native form without having to be combined with the bound-powder matrix or binding liquid. Dosage forms can disintegrate in water or saliva in less than two minutes, independently of the payload(s) or medicament(s) contained within. The dosage forms can be formed as unitary tablets, or as two-piece tablets comprising a container body and a lidding body that are secured together to isolate the one or more cavities and their payloads inside.
A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.
A61J 3/06 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de pilules, tablettes ou pastilles
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted powder layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations, namely, a drug delivery system consisting of compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents
31.
METHOD AND SYSTEM FOR FORMING A DOSAGE FORM WITHIN A PACKAGING
A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.
B65D 75/36 - Objets ou matériaux enveloppés entre deux feuilles ou flans opposés à bords réunis, p. ex. par adhésifs à pression, pliage, thermosoudage ou soudage une ou les deux feuilles ou flans étant renfoncés pour épouser la forme du contenu une feuille ou un flan étant renfoncés et l'autre fait d'une feuille plate relativement rigide, p. ex. empaquetage pour ampoules
32.
Three-dimensional printing system and equipment assembly
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p. ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B29C 64/20 - Appareil pour la fabrication additiveDétails ou accessoires à cet effet
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/386 - Acquisition ou traitement de données pour la fabrication additive
B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p. ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations, namely, compounds in a unitary solid dosage form made by a three-dimensional printing process for the rapid dispersion of a wide variety of therapeutic agents Development of pharmaceutical and nutraceutical preparations for others; research and development in the pharmaceutical and nutraceutical fields for others
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Development of pharmaceutical and nutraceutical preparations for others; research and development in the pharmaceutical and nutraceutical fields for others
36.
Three-dimensional printing system and equipment assembly
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
B29C 67/00 - Techniques de façonnage non couvertes par les groupes , ou
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B29C 64/106 - Procédés de fabrication additive n’utilisant que des matériaux liquides ou visqueux, p. ex. dépôt d’un cordon continu de matériau visqueux
B33Y 50/02 - Acquisition ou traitement de données pour la fabrication additive pour la commande ou la régulation de procédés de fabrication additive
B29C 64/20 - Appareil pour la fabrication additiveDétails ou accessoires à cet effet
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
B29C 64/241 - Moyens d’entraînement pour mouvement rotatif
B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p. ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
B30B 11/08 - Presses spécialement adaptées à la fabrication d'objets à partir d'un matériau en grains ou à l'état plastique, p. ex. presses à briquettes ou presses à tablettes utilisant un pilon exerçant une pression sur le matériau dans une cavité de moulage coopérant avec des moules portés par une table tournante
B29C 64/176 - Procédés de fabrication additive spécialement adaptés à la fabrication d'objets multiples en 3D successivement
B28B 11/06 - Appareillages ou procédés pour le traitement ou le travail des objets façonnés pour le revêtement avec des matériaux en poudre ou granulés
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
B29C 64/379 - Manutention des objets en 3D obtenus, p. ex. à l’aide de robots
B33Y 40/00 - Opérations ou équipements auxiliaires, p. ex. pour la manipulation de matériau
B29C 64/188 - Procédés de fabrication additive impliquant des opérations supplémentaires effectuées sur les couches ajoutées, p. ex. lissage, meulage ou contrôle d’épaisseur
B29C 64/30 - Opérations ou équipements auxiliaires
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
B29K 105/00 - Présentation, forme ou état de la matière moulée
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Development of pharmaceutical and nutraceutical preparations for others, namely, pharmaceutical and nutraceutical compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents; research and development in the pharmaceutical and nutraceutical fields for others, namely, research and development of pharmaceutical and nutraceutical compounds in a unitary solid dosage form for the rapid dispersion of a wide variety of therapeutic agents
A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of water soluble drug in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to the drug.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
B33Y 70/00 - Matériaux spécialement adaptés à la fabrication additive
B33Y 80/00 - Produits obtenus par fabrication additive
B29C 64/165 - Procédés de fabrication additive utilisant une combinaison de matériaux solides et liquides, p. ex. une poudre avec liaison sélective par liant liquide, catalyseur, inhibiteur ou absorbeur d’énergie
B29K 105/00 - Présentation, forme ou état de la matière moulée
41.
Three-dimensional printing system and equipment assembly
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non- pharmaceutical / non-medical objects. It can be used to prepare single or multiple articles.
B05D 1/26 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces par application de liquides ou d'autres matériaux fluides, à partir d'un orifice en contact ou presque en contact avec la surface
B28B 11/06 - Appareillages ou procédés pour le traitement ou le travail des objets façonnés pour le revêtement avec des matériaux en poudre ou granulés
B29C 35/08 - Chauffage ou durcissement, p. ex. réticulation ou vulcanisation utilisant l'énergie ondulatoire ou un rayonnement corpusculaire
B29C 67/00 - Techniques de façonnage non couvertes par les groupes , ou
B33Y 30/00 - Appareils pour la fabrication additiveLeurs parties constitutives ou accessoires à cet effet
A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.
A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61J 3/06 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de pilules, tablettes ou pastilles
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof.
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 15 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to levetiracetam.
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.
A61J 3/06 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de pilules, tablettes ou pastilles
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
A high dose orodispersible dosage form of oxcarbazepine is provided. Drug-containing particles of oxcarbazepine are included within a porous bound matrix. The dosage form disperses in saliva or water in less than 15 sec and it has sufficient hardness to withstand handling and storage. It can be used to treat diseases or disorders that are therapeutically responsive to oxcarbazepine or a derivative thereof.
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
A high dose rapidly dispersing three-dimensionally printed dosage form comprising a high dose of levetiracetam in a porous matrix that disperses in water within a period of less than about 10 seconds is disclosed. Also disclosed are methods of preparing the dosage form and of treating a condition, disease or disorder that is therapeutically responsive to levetiracetam.
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations, namely, compounds in a unitary solid dosage form made by a three-dimensional printing process for the rapid dispersion of a wide variety of therapeutic agents
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations, namely, compounds in a unitary solid dosage form made by a three-dimensional printing process for the rapid dispersion of a wide variety of therapeutic agents
A three-dimensional printing system and equipment assembly for the manufacture of three-dimensionally printed articles is provided. The equipment assembly includes a three-dimensional printing build system, an optional liquid removal system and an optional harvester system. The build system includes a conveyor, plural build modules and at least one build station having a powder-layering system and a printing system. The equipment assembly can be used to manufacture pharmaceutical, medical, and non-pharmaceutical/non-medical objects. It can be used to prepare single or multiple articles.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Development of pharmaceutical and nutraceutical preparations for others; research and development in the pharmaceutical and nutraceutical fields for others Medical and pharmaceutical consultancy, namely, consultation regarding biotechnological products for use in preparing pharmaceutical and nutraceutical preparations, namely, drug delivery systems
Pharmaceutical dosage forms with external or internal features to complicate counterfeiting and support authentication are described. External features include surface texture, surface markings defined by patterns of physical or chemical markers, or complex interlocking shapes. Internal features also include physical or chemical markers in two or three-dimensional patterns observable after sectioning, or after breaking along designed fracture lines. Methods of manufacture using solid freeform fabrication (SFF) techniques such as three-dimensional printing (3DP) are described. Method of authentication using dosage form patterns and batch codes are also described.
The invention includes a core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles of a release-regulating polymer. The shell may be substantially impervious but the release-regulating polymer may become suitable to allow diffusion through it when activated. The core may include a buffer region between the shell and the API-containing portion of the core. The dosage form may include multiple units. The dosage form of the invention is capable of providing a release profile whose time scale can be adjusted by adjusting powder composition, and which may be approximately zero-order release. The invention further includes methods of manufacturing such a dosage form, such as three-dimensional printing.
