The present disclosure relates to an improved process for the regio- and stereospecific synthesis of polyprenyl compounds. More particularly it discloses regio- and stereospecific synthesis of (2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14, 18, 22,26 heptane-1-ol which finds use in the synthesis of Vitamin K2-7.
C07C 29/00 - Préparation de composés comportant des groupes hydroxyle ou O-métal liés à un atome de carbone ne faisant pas partie d'un cycle aromatique à six chaînons
C07C 33/02 - Alcools acycliques à liaisons doubles carbone-carbone
The present disclosure relates to the synthesis of Vitamin K2 bearing varying prenyl side chains. The synthesis comprises the reaction of phenyl sulfone of tert-butyl dimethyl silyl (TBDMS) protected mono prenyl menadiol with prenyl halides bearing varying prenyl units in the presence of the phase transfer catalyst followed by reductive desulphonation to yield TBDMS ether of Vitamin K2. The TBDMS ether is then oxidized in the presence of chromium trioxide and periodic acid to yield the corresponding Vitamin K2.
C07C 46/02 - Préparation de quinones par oxydation avec formation de structures quinoïdes
C07C 46/06 - Préparation de quinones par oxydation avec formation de structures quinoïdes d'au moins un groupe hydroxyle d'un cycle aromatique à six chaînons
C07C 315/00 - Préparation de sulfonesPréparation de sulfoxydes
C07C 315/04 - Préparation de sulfonesPréparation de sulfoxydes par des réactions n'impliquant pas la formation de groupes sulfone ou sulfoxyde
3.
NOVEL MENAQUINONE-N (VITAMIN-K2-7) SUPPLEMENTATION FOR LIVESTOCK AND POULTRY
The present invention relates to novel animal feed supplements that comprise menaquinone-n, wherein (n) is the number of repeating 5 carbon units. The supplements further comprise saccharides, carotenoids, xanthophylls, minerals and electrolytes. The animal feed supplement comprises menaquinone-n, wherein (n) is the number of repeating 5 carbon units, enhances and the growth, reduces the mortality, and improves the feed conversion ratio, improves liver and bone health, and replaces the need for use of probiotics in livestock and/or poultry, especially monogastric livestock and/or poultry receiving such animal feed supplements.
C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
4.
Process for stereospecific synthesis of vitamin K2 and its novel intermediates
The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
C07C 46/06 - Préparation de quinones par oxydation avec formation de structures quinoïdes d'au moins un groupe hydroxyle d'un cycle aromatique à six chaînons
C07C 317/14 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde liés à des atomes de carbone de cycles aromatiques à six chaînons
5.
A PROCESS FOR THE STEREOSPECIFIC SYNTHESIS OF VITAMIN K2 AND ITS INTERMEDIATES
The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.
C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
C07C 41/18 - Préparation d'éthers par des réactions ne formant pas de liaisons sur l'oxygène de la fonction éther
C07C 50/28 - Quinones contenant des groupes dont les atomes d'oxygène sont liés par liaison simple à des atomes de carbone à structure quinoïde monocyclique
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Nutraceuticals for use as a dietary supplement for general health and well-being; nutraceuticals for use as a dietary supplement for supplementation as a food ingredient for general health and well-being.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Bacterial preparations for the food industry; probiotic
bacteria for the food industry (in food supplement);
probiotic bacterial cultures for the food industry; chemical
additives for use in the manufacture of food; antioxidants
for use in the manufacture of food supplements.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Bacterial preparations for the food industry; probiotic
bacteria for the food industry (in food supplement);
probiotic bacterial cultures for the food industry; chemical
additives for use in the manufacture of food; antioxidants
for use in the manufacture of food supplements.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
(1) Bacterial preparations for the food industry; probiotic bacteria for the food industry (in food supplement); probiotic bacterial cultures for the food industry; chemical additives for use in the manufacture of food; antioxidants for use in the manufacture of food supplements.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Bacteria for use in food manufacture; Bacterial preparations for the food industry; Probiotic compositions for use as ingredients for food and beverages, namely, probiotic bacteria and probiotic bacterial cultures for use in the manufacture of food supplements; Chemical additives for use in the manufacture of food; Antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of pharmaceuticals
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
Produits et services
Bacteria for use in food manufacture; Bacterial preparations for the food industry; Probiotic compositions for use as ingredients for food and beverages, namely, probiotic bacteria and probiotic bacterial cultures for use in the manufacture of food supplements; Chemical additives for use in the manufacture of food; Antioxidants for use in the manufacture of food supplements; Antioxidants for use in the manufacture of pharmaceuticals
16.
Vitamin K2 compositions for the treatment of drug induced neuropathy
The present invention provides the use of vitamin K2 compositions for the treatment of drug-induced neuropathy. More particularly it is related to the use of vitamin K2-7 compositions for the treatment of drug-induced peripheral neuropathy caused by the drugs used for the treatment of multiple myeloma.
A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
A61P 25/02 - Médicaments pour le traitement des troubles du système nerveux des neuropathies périphériques
A61K 31/4375 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. quinolizines, naphtyridines, berbérine, vincamine
A61K 31/454 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pimozide, dompéridone
A61K 31/573 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes substitués en position 17 bêta par une chaîne à deux atomes de carbone, p. ex. prégnane ou progestérone substitués en position 21, p. ex. cortisone, dexaméthasone, prednisone ou aldostérone
A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
The present invention provides the use of vitamin K2 compositions for the treatment of drug- induced neuropathy. More particularly it is related to the use of vitamin K2-7 compositions for the treatment of drug- induced peripheral neuropathy caused by the drugs used for the treatment of multiple myeloma.
C07C 50/14 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant deux cycles avec insaturation autre que celle du système cyclique, p. ex. vitamine K1
The present invention provides a stable liquid syrup composition compositions comprising probiotic bacteria, retaining their cellular viability at ambient storage conditions for at least two years.
The present invention provides a stable liquid syrup composition compositions comprising probiotic bacteria, retaining their cellular viability at ambient storage conditions for at least two years.
A23C 9/123 - Préparations à base de lait fermentéTraitements utilisant des micro-organismes ou des enzymes ne comportant que des micro-organismes de la famille des lactobactériacéesYoghourt
A23C 9/127 - Préparations à base de lait fermentéTraitements utilisant des micro-organismes ou des enzymes comportant des micro-organismes de la famille des lactobactériacées et d'autres micro-organismes ou des enzymes, p. ex. kéfir, koumiss
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Animal feed additive for use as a nutritional supplement for medical purposes; Animal feed supplements; Bee pollen for use as a dietary food supplement; Biscuits, bread, bread rolls, cakes, cereal products, confectionery, crackers, noodles, fish sauce, relish, sauces, cereal-based snack-foods and prepared dietary items that are gluten-free to accommodate special medical and health conditions; Calcium supplements; Dietary and nutritional supplements; Dietary and nutritionally fortified food products adapted for medical use; Dietary drink mix for use as a meal replacement; Dietary fiber as an additive for food products; Dietary food supplements; Dietary supplemental drinks; Dietary supplements; Dietary supplements for animals; Dietary supplements for human consumption; Dietary supplements for pets; Feed supplements for dogs; Fish, pickles, preserved olives and dietary foods and food-items that are gluten-free to accommodate special medical and health conditions; Food supplements; Food supplements, namely, anti-oxidants; Ground flaxseed fiber for use as a dietary supplement; Herbal supplements; Homeopathic supplements; Lecithin for use as a dietary supplement; Meal replacement and dietary supplement drink mixes; Mineral food supplements; Mineral nutritional supplements; Mineral supplements; Non-medicated additives for animal feed for use as nutritional supplements; Nutraceuticals for use as a dietary supplement; Nutritional additives for medical purposes for use in foods and dietary supplements for human consumption; Nutritional supplements; Nutritional supplements in lotion form sold as a component of nutritional skin care products; Powdered fruit-flavored dietary supplement drink mix; Powdered nutritional supplement drink mix; Vitamin and mineral supplements; Vitamin supplement in tablet form for use in making an effervescent beverage when added to water; Vitamin supplements; Vitamins and dietary food supplements for animals; Wheat for use as a dietary supplement
