Abrégé

A method for preparing peptides is disclosed, the method comprising a step of forming a peptide bond wherein the carboxyl group of a first amino acid or first peptide is activated and an amino group of the first activated amino acid or first peptide is protected by a protecting group having a water-solubility enhancing group and the activated carboxyl group of the first amino acid or first peptide is reacted with an amino group of a second amino acid or second peptide wherein said carboxyl group of the first amino acid or first peptide is activated in the absence of the second amino acid or second peptide. Peptides comprising a protecting group having a water-solubility enhancing group being bound to the amino group and an activated or free carboxyl group are also disclosed.

Classes IPC  ?

• C07K 1/02 - Procédés généraux de préparation de peptides en solution
• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C07K 1/06 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation
• C07K 1/08 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation utilisant des agents d'activation
• C07K 1/10 - Procédés généraux de préparation de peptides utilisant des agents de couplage
• C07K 1/18 - Chromatographie d'échange d'ions

Abrégé

The invention relates to a method for preparing peptides comprising the step of forming a peptide bond wherein the carboxyl group of a first amino acid or first peptide is activated and an amino group of the first activated amino acid or first peptide is protected by a protecting group having a water-solubility enhancing group and the activated carboxyl group of the first amino acid or first peptide is reacted with an amino group of a second amino acid or second peptide wherein said carboxyl group of the first amino acid or first peptide is activated in the absence of the second amino acid or second peptide. The invention further relates to peptides comprising a protecting group having a water-solubility enhancing group being bound to the amino group and an activated or free carboxyl group.

Classes IPC  ?

• C07K 1/02 - Procédés généraux de préparation de peptides en solution
• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C07K 1/06 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation
• C07K 1/08 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation utilisant des agents d'activation
• C07K 1/10 - Procédés généraux de préparation de peptides utilisant des agents de couplage
• C07K 1/18 - Chromatographie d'échange d'ions

Abrégé

The invention relates to a method for preparing peptides comprising the step of forming a peptide bond wherein the carboxyl group of a first amino acid or first peptide is activated and an amino group of the first activated amino acid or first peptide is protected by a protecting group having a water-solubility enhancing group and the activated carboxyl group of the first amino acid or first peptide is reacted with an amino group of a second amino acid or second peptide wherein said carboxyl group of the first amino acid or first peptide is activated in the absence of the second amino acid or second peptide. The invention further relates to peptides comprising a protecting group having a water-solubility enhancing group being bound to the amino group and an activated or free carboxyl group.

Classes IPC  ?

• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C07K 1/06 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation

Abrégé

The invention relates to a method for preparing peptides comprising the step of forming a peptide bond wherein at least one amino acid or peptide comprises a protecting group having a water-solubility enhancing group, and said forming of a peptide bond is achieved while an amino acid or a peptide is bound to a solid phase. The invention further relates to peptides comprising a protecting group having a water-solubility enhancing group being bound to the amino group and an activated or free carboxyl group.

Classes IPC  ?

• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C07K 1/06 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation

Abrégé

The invention relates to Si6, Si8, Si10 and Si12 silsesquinoxane compounds containing guanidine or quaternary ammonium groups and to their use as transporter molecules for pharmaceutical, photoactive or isotope-marked compounds.

Classes IPC  ?

• C07F 7/21 - Composés cycliques ayant au moins un cycle comportant du silicium mais sans carbone dans le cycle
• A61K 31/695 - Composés du silicium
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur

Abrégé

The invention relates to a method for peptide synthesis, wherein said method comprises the steps of reacting a first amino acid or a first peptide with an α-amine protected second amino acid in a solvent selected from the group consisting of water, alcohol, and a mixture of water and alcohol, and removing the α-amine protecting group with a deprotecting solution. The invention further relates to protective agents, their use and an apparatus for carrying out a method for solid phase synthesis of peptides.

Classes IPC  ?

• C07K 1/10 - Procédés généraux de préparation de peptides utilisant des agents de couplage
• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C07K 1/02 - Procédés généraux de préparation de peptides en solution
• C07K 1/06 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation

Produits et services

Chemicals for use in industry and science; Chemical substances, chemical materials, chemical preparations, natural elements and kits comprising the aforesaid goods for industrial and scientific purposes; Proteins, Peptides, Protective groups and protected amino acids (chemicals), included in class 1; Chemicals, chemical substances, chemical materials, chemical preparations, natural elements and kits comprising the aforesaid goods and proteins, peptides, protective groups and protected amino acids (in class 1) for or for use in connection with DNA studies, chemiluminescent technology, liquid chromatography and mass spectrometry, proteome and protein analysis, diagnostics, nucleic acid synthesis, peptide nucleic acid synthesis, peptidomimetic synthesis, oligo synthesis, polymerase chain reactions and applications connected thereto, protein and peptide synthesis, solid-phase peptide synthesis, liquid-phase peptide synthesis, peptide fragment condensation, hybrid peptide synthesis, fluorescence technology, cytometry, nucleic acid extracts. Pharmaceutical and veterinary preparations; Dietetic substances adapted for medical purposes; Nutritional supplements; Proteins, peptides, protective groups and protected amino acids (pharmaceutical and veterinary preparations, dietetic substances adapted for medical use), included in class 5; Pharmaceutical and veterinary preparations, dietetic substances, dietary supplements and proteins, peptides, protective groups and protected amino acids (in class 5) for or for use in connection with DNA studies, chemiluminescent technology, liquid chromatography and mass spectrometry, proteome and protein analysis, diagnostics, nucleic acid synthesis, peptide nucleic acid synthesis, peptidomimetic synthesis, oligo synthesis, polymerase chain reactions and applications connected thereto, protein and peptide synthesis, solid-phase peptide synthesis, liquid-phase peptide synthesis, peptide fragment condensation, hybrid peptide synthesis, fluorescence technology, cytometry, nucleic acid extraction. Scientific, optical, measuring, checking (supervision) and teaching apparatus and instruments; Spare parts for scientific, optical, measuring, checking (supervision) and teaching apparatus and instruments (included in class 9); Scientific, optical, measuring, checking (supervision) and teaching apparatus and instruments and spare parts therefor (included in class 9), for or for use in connection with DNA studies, chemiluminescent technology, liquid chromatography and mass spectrometry, proteome and protein analysis, diagnostics, nucleic acid synthesis, peptide nucleic acid synthesis, peptidomimetic synthesis, oligo synthesis, polymerase chain reactions and applications connected thereto, protein and peptide synthesis, solid-phase peptide synthesis, liquid-phase peptide synthesis, peptide fragment condensation, hybrid peptide synthesis, fluorescence technology, cytometry, nucleic acid extraction. Scientific and technological services and research and design relating thereto; Industrial analysis and research services; Design and development of computer hardware and software; Laboratory services; Processing of samples; Scientific and technological design services and research and design connected thereto, industrial analysis and research services, design and development of computer hardware and software, laboratory services and processing of samples for, in connection with, or with use of DNA studies, chemiluminescent technology, liquid chromatography and mass spectrometry, proteome and protein analysis, diagnostics, nucleic acid synthesis, peptide nucleic acid synthesis, peptidomimetic synthesis, oligo synthesis, polymerase chain reactions and applications connected thereto, protein and peptide synthesis, solid-phase peptide synthesis, liquid-phase peptide synthesis, peptide fragment condensation, hybrid peptide synthesis, fluorescence technology, cytometry, nucleic acid extraction. Medical services; Veterinary services; Hygienic and beauty care for human beings or animals; Medical and veterinary services, and hygienic and beauty care for human beings or animals for, in connection with or with use of DNA studies, chemiluminescent technology, liquid chromatography and mass spectrometry, proteome and protein analysis, diagnostics, nucleic acid synthesis, peptide nucleic acid synthesis, peptidomimetic synthesis, oligo synthesis, polymerase chain reactions and applications connected thereto, protein and peptide synthesis, solid-phase peptide synthesis, liquid-phase peptide synthesis, peptide fragment condensation, hybrid peptide synthesis, fluorescence technology, cytometry, nucleic acid extraction.

Abrégé

The invention relates to a method for peptide synthesis, wherein said method comprises the steps of reacting a first amino acid or a first peptide with an α-amine protected second amino acid in a solvent selected from the group consisting of water, alcohol, and a mixture of water and alcohol, and removing the α-amine protecting group with a deprotecting solution. The invention further relates to protective agents, their use and an apparatus for carrying out a method for solid phase synthesis of peptides.

Classes IPC  ?

• C07K 1/02 - Procédés généraux de préparation de peptides en solution
• C07K 1/04 - Procédés généraux de préparation de peptides sur des supports
• C07K 1/06 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation
• C07K 1/10 - Procédés généraux de préparation de peptides utilisant des agents de couplage

Abrégé

The invention relates to a method for peptide synthesis, wherein said method comprises the steps of reacting a first amino acid or a first peptide with an a-amine protected second amino acid in a solvent selected from the group consisting of water, alcohol, and a mixture of water and alcohol, and removing the a-amine protecting group with a deprotecting solution. The invention further relates to protective agents, their use and an apparatus for carrying out a method for solid phase synthesis of peptides.

Classes IPC  ?

• C07K 1/06 - Procédés généraux de préparation de peptides utilisant des groupes protecteurs ou des agents d'activation
• C07K 1/10 - Procédés généraux de préparation de peptides utilisant des agents de couplage