Systems and methods relate to electrically manipulating optical quantum systems. Quantum emitters can be coupled to an electric field exerted across an integrated lateral reverse-biased semiconductor diode. This electric field exerted through the reverse-biased diode can broaden, narrow, and/or shift de-excitation photon wavelengths. Such emitter-field coupling of quantum emitters embedded in semiconductor diodes can produce stabilized and tunable de-excitation photon emission. Such stabilization and tuning can allow for the coherent transmission of entangled photon quantum states. Individual quantum emitters or large ensembles of quantum emitters can be hosted in semiconductor diodes constructed by ordinary lithographic techniques within versatile media. The designs and techniques disclosed can facilitate scalable, efficient production of semiconductor diode and embedded quantum emitter devices for manipulable, deterministic transmission of quantum information.
H10H 20/812 - Corps ayant des structures ou des superréseaux à effet quantique, p. ex. jonctions tunnel au sein des régions électroluminescentes, p. ex. structures de confinement quantique
B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
Disclosed herein are methods for generating mature cardiomyocytes and compositions including mature cardiomyocytes. Also disclosed herein are methods for enhancing electrophysiological maturation of cardiomyocytes.
Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/372 - Aménagements en relation avec l'implantation des stimulateurs
A61N 1/375 - Aménagements structurels, p. ex. boîtiers
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
The present disclosure generally relates to nanoscale wires and nanoelectronics. Certain non-limiting embodiments are generally directed to implantation of stretchable electronics, e.g., in organisms, such as juveniles. For example, one aspect is generally directed to a stretchable component, which may form a part of an electrical circuit. The component may be connectable in certain embodiments to an external device, e.g., to determine a property of the component (e.g., an electrical property), and/or to apply a stimulus (e.g., an electrical stimulus) to a tissue in the organism. Other aspects are generally directed to methods of making or using such components, kits including such components, biological structures containing such components, or the like.
Methods, systems, and compositions comprising genomic encryption are detailed herein. Also provided are methods and applications for authenticating biological material utilizing genomic encryption.
G16B 20/20 - Détection d’allèles ou de variantes, p. ex. détection de polymorphisme d’un seul nucléotide
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
7.
ENGINEERED MICROBE THAT INCREASES ROCK DISSOLUTION
The technology described herein is directed to microbes that are genetically engineered to continually express and/or produce an excess of genes needed to produce at least one siderophore. In other aspects, described herein are nucleic acid constructs comprising exemplary genes used to produce at least one siderophore. Also described herein are compositions comprising the engineered microbes in combination with silicate rock or sand. In further aspects, described herein are methods of using such engineered microbes, including but not limited to producing siderophores, promoting mineral dissolution including of silicate rock or sand, and/or promoting carbon sequestration, including from or in seawater. In other aspects, described herein are reactor vessels containing such engineered microbes, including in combination with silicate rock or sand.
Provided herein are compounds useful for inducing biostasis. Also provided are pharmaceutical compositions comprising the compounds, kits comprising the compounds, methods of inducing biostasis in subjects, biological samples and cells, and methods of preserving biological samples (e.g., mammalian tissue) by a compound or composition described herein.
The present disclosure is generally directed to systems and methods for retrieving cells from a continuous culture microfluidic device. In some aspects, a system that allows for selective extraction of one or more cells of interest from an arbitrary population of cells using a high-throughput negative cell selection technique is disclosed herein. For example, the system may comprise a microfluidic device comprising a plurality of cell growth trenches configured to contain cells and a patterned light source capable of selectively killing unwanted cells contained within the device. Coupled with time-lapse imaging, one or more cells of interest within the device may, in some aspects, be identified and extracted with a relatively high extraction efficiency, e.g., at least 99.9% of cells of interest may be extracted from the plurality of cells. In addition, some aspects of the disclosure are directed to methods for using such a system.
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
11.
SINGLE PHOTON DETECTOR BASED ON THE KINETIC INDUCTANCE OF TWO-DIMENSIONAL VAN DER WAALS MATERIALS
The Trustees of Columbia University in the City of New York (USA)
Inventeur(s)
Fong, Kin Chung
Ranzani, Leonardo Matteo
Kreidel, Mary
Westervelt, Robert M.
Balgley, Jesse
Chu, Xuanjing
Hone, James Curtis
Abrégé
A single photon detector based on the kinetic inductance of two-dimensional Van der Waals materials. In some embodiments, a system including such a detector includes: a resonator including a conductive path through a superconducting sheet, the superconducting sheet being composed of a Van der Waals material, the superconducting sheet being configured to absorb a photon, and in response to the absorption of the photon, to exhibit an increase in a kinetic inductance of the conductive path.
G01J 5/20 - Pyrométrie des radiations, p. ex. thermométrie infrarouge ou optique en utilisant des détecteurs électriques de radiations en utilisant des éléments résistants, thermorésistants ou semi-conducteurs sensibles aux radiations, p. ex. des dispositifs photoconducteurs
The present disclosure provides compositions and methods for prime editing with improved editing efficiency and/or reduced indel formation with modified prime editors and prime editor fusion proteins. The disclosure further provides, vectors, cells, and kits comprising the compositions and polynucleotides of the disclosure.
The invention features compositions and methods for treating diseases or disorders associated with undesirable neuronal excitability (e.g., de-myelinating disease, neurodegenerative disease, such as Parkinson's disease or Huntington's disease; or chronic pain, or epilepsy).
15.
FUNCTIONALIZED SILICA NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
Provided are compounds useful for the treatment and prevention of infectious diseases. The compound structures are lincosamide analogs modified at the aminooctose (northern) and amino acid (southern) regions. Also provided are methods for preparing the lincosamide compounds, pharmaceutical compositions comprising the lincosamide compounds, and methods of treating infectious diseases using the disclosed lincosamide compounds.
C07H 15/26 - Radicaux acycliques ou carbocycliques substitués par des hétérocycles
A61K 31/7056 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à cinq chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing proteins or protein domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing proteins or domains, are provided.
Methods of labelling one or more subcellular components (e.g., an organelle and/or subcellular region) in vivo are provided. Methods of labelling a protein in vivo are provided. Methods of determining a nucleic acid sequence in situ are also provided.
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
Provided herein are antiviral compounds including compounds of Formulae (I), (II'), (II), and (III), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, and pharmaceutical compositions thereof. The compounds provided herein are useful for the treatment and/or prevention of infectious diseases (e.g., viral infections including COVID-19). In other aspects, provided herein are kits comprising compounds and pharmaceutical compositions described herein, methods of synthesizing the compounds provided herein, and intermediates useful in the synthesis of compounds provided herein. Formula (II):
Techniques for performing medical tasks using a medical artificial intelligence (MAI) system including receiving multi-modal input; processing at least a portion of the multi-modal input using a trained LLM to obtain LLM output indicating that zero, one, or multiple tasks are to be additionally performed; when the LLM output indicates that zero tasks are to be additionally performed, outputting at least some of the LLM output as a response to the request; and when the LLM output indicates that one or multiple tasks are to be additionally performed, processing at least some of the multi-modal input, using at least one of a plurality of task-specific software tools and the LLM output, to obtain at least one task-specific output; and outputting a response generated using the at least some of the LLM output and the at least one task-specific output as a response to the request.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
G06F 40/284 - Analyse lexicale, p. ex. segmentation en unités ou cooccurrence
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids or the modification of nucleic acids or proteins, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of nucleic acid programmable DNA binding proteins e.g., GeoCas9 or variants thereof, and effector domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing or protein modification are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of a GeoCas9 and effector domains, are provided.
Described are methods for producing tissue constructs, tissue constructs produced by the methods, and their use. The described method of producing a tissue construct comprises providing a granular tissue, depositing one or more filaments on or in the granular tissue, each filament comprising an ink, and gelling or fusing the granular tissue, thereby producing the tissue construct.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61L 27/44 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent comportant une matrice macromoléculaire
A61L 27/50 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
A61L 27/54 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
The present disclosure is directed to injectable adhesives designed for muscle regeneration that are self-healing, highly stretchable, and biodegradable, along with providing strong tissue adhesion. Applied to muscle injuries, they improved healing, with treated mice showing greater muscle weight and strength than controls, advancing medical adhesive technology.
C08L 33/08 - Homopolymères ou copolymères des esters de l'acide acrylique
A61L 24/06 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons carbone-carbone non saturées
Provided herein are methods and compositions for differentiating induced pluripotent stem cells into microglia-like cells by overexpressing transcription factors such as SPI1, CEBPA, FLU, MEF2C, CEBPB, and/or IRF8.
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
26.
ASYMMETRIC LIPOSOMES FOR DRUG DELIVERY AND OTHER APPLICATIONS
Some aspects of the present disclosure are generally related to systems including asymmetric liposomes, for example, for drug delivery. In some embodiments, the asymmetric liposomes facilitate the encapsulation of therapeutic agents. In some embodiments, the system may include a plurality of asymmetric liposome and a plurality of cells, e.g., within a subject. According to some embodiments, cells may uptake the asymmetric liposomes at an enhanced rate when compared to conventionally used symmetric liposomes, e.g., while also comparatively being less cytotoxic. In some embodiments, the enhanced rate of uptake of the asymmetric liposomes by cells improve delivery of a therapeutic agent encapsulated within the asymmetric liposomes to the cells. Still other aspects are generally directed to methods of making and using the liposomes, kits containing the liposomes, or the like.
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 9/1272 - Liposomes non conventionnels, p. ex. liposomes modifiés par un PEG ou liposomes enduits de ou greffés avec des polymères comprenant des agents tensioactifs non phosphatidyliques comme substances formant des bicouches, p. ex. lipides cationiques ou liposomes non phosphatidyliques enduits de ou greffés avec des polymères
Disclosed herein are lanthanide-doped upconverting nanoparticles and methods of making the same. Also disclosed are methods of imaging target proteins and methods of performing single particle tracking comprising the upconverting nanoparticles of this disclosure.
C09K 11/77 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant des métaux des terres rares
C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
C01F 17/36 - Composés contenant des métaux de terres rares et au moins un élément autre qu’un métal des terres rares, l'oxygène ou l'hydrogène, p. ex. La4S3Br6 le seul anion étant un halogénure, p. ex. NaYF4
G01N 33/533 - Production de composés immunochimiques marqués avec un marqueur fluorescent
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing on-line chat rooms for transmission of messages among computer users concerning dialogue on civic engagement and political issues Providing an online non-downloadable Internet-based system application featuring technology enabling users to engage in online video-based discourse on civic engagement and political issues
29.
QUANTUM LOW-DENSITY PARITY-CHECK CODES WITH RECONFIGURABLE ATOM ARRAYS
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
Inventeur(s)
Zhou, Hengyun
Ataides, Juan Pablo, Bonilla
Bluvstein, Dolev
Wurtz, Jonathan
Lukin, Mikhail, D.
Xu, Qian
Jiang, Liang
Pattison, Christopher, A.
Raveendran, Nithin
Vasic, Bane
Abrégé
Quantum error correction in reconfigurable atom arrays is described. A plurality of data qubits is provided, each of the plurality of data qubits disposed in a corresponding trap. A plurality of ancilla qubits is provided, each of the plurality of ancilla qubits disposed in a corresponding trap. The plurality of data qubits and the plurality of ancilla qubits are arranged in a plurality of rows and a plurality of columns, thereby forming a lattice. A plurality of permutations of the plurality of rows and the plurality of columns is performed, each of the plurality of permutations placing each of the plurality of data qubits within an interaction radius of one of the plurality of ancilla qubits, thereby forming a plurality of proximate pairs. Subsequent to each of the plurality of permutations, a global control pulse is applied to the lattice, thereby applying a gate to each of the plurality of proximate pairs, and thereby encoding a parity check matrix between the plurality of ancilla qubits and the plurality of data qubits.
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (USA)
CALIFORNIA INSTITUTE OF TECHNOLOGY (USA)
THE UNIVERSITY OF CHICAGO (USA)
Inventeur(s)
Zhou, Hengyun
Ataides, Juan, Pablo, Bonilla
Bluvstein, Dolev
Wurtz, Jonathan
Lukin, Mikhail, D.
Xu, Qian
Jiang, Liang
Pattison, Christopher, A.
Raveendran, Nithin
Vasic, Bane
Abrégé
Constant-overhead fault-tolerant quantum computation is provided. A first plurality of physical qubits is configured to encode a first plurality of logical qubits using a quantum low-density parity-check (qLDPC) code. A second plurality of physical qubits is configured to encode a second plurality of logical qubits using an error-correcting code; and a plurality of ancilla qubits. The quantum computing system is configured to teleport at least one of the first plurality of logical qubits into a corresponding at least one of the second plurality of logical qubits via the plurality of ancilla qubits. The quantum computing system is configured to perform at least one logical operation on the at least one of the second plurality of logical qubits. The quantum computing system is configured to teleport the at least one of the second plurality of logical qubits into the at least one of the first plurality of qubits via the plurality of ancilla qubits.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Software as a service (SAAS) services featuring software using artificial intelligence (AI) for business strategy development, namely, providing assistance in development of business strategies and creative ideation
32.
OPTICALLY ADDRESSABLE ACTUATORS AND RELATED METHODS
Addressable actuator and arrays thereof are described. Actuators may be dielectric elastomer actuators (DBAs). An addressable actuator may include a compliant substrate, with an optical receiver integrated with a first region of the compliant substrate and an actuator integrated with a second region of the compliant substrate, with the optical receiver coupled to the actuator. The optical receivers may comprise percolating networks of semiconductor materials, such as photoconductive channels of zinc oxide nanowires, which may be embedded in a compliant substate, or one or more compliant layers (which may be formed on a substrate). Compliant substrates or layers may include complaint materials such as an elastomer. An actuator array may comprise multiple of the actuators, with each actuator being independently optically addressable. A system may include light emitting devices optically coupled to respective optical receivers to control actuation of the actuators using light.
H10D 62/10 - Formes, dimensions relatives ou dispositions des régions des corps semi-conducteursFormes des corps semi-conducteurs
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
H10D 62/00 - Corps semi-conducteurs, ou régions de ceux-ci, de dispositifs ayant des barrières de potentiel
H10D 62/86 - Corps semi-conducteurs, ou régions de ceux-ci, de dispositifs ayant des barrières de potentiel caractérisés par les matériaux étant des matériaux du groupe II-VI, p. ex. ZnO
H10F 55/00 - Dispositifs à semi-conducteurs sensibles au rayonnement couverts par les groupes , ou structurellement associés à des sources lumineuses électriques et électriquement ou optiquement couplés avec lesdites sources
33.
ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors with additional functional domains. Also provided are methods of directing CRISPIR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
C08J 3/03 - Production de solutions, dispersions, latex ou gel par d'autres procédés que ceux utilisant les techniques de polymérisation en solution, en émulsion ou en suspension dans un milieux aqueux
A device can include a laser. The device can include a waveguide coupled with the laser and configured to output a pulse having a plurality of wavelengths forming a frequency comb in a range between 3 μm and 12 μm. The device can include a resonator coupled with the waveguide. The resonator can include a closed loop. The device can include gain medium disposed in the resonator. A portion of the waveguide and a portion of the resonator can form a coupler.
The technology is directed to transgene constructs that use at least one intron to provide interspecies biocontainment. The transgene construct can comprise a polypeptide coding sequence interrupted by at least one heterologous intron sequence. Also described herein are nucleic acids, pharmaceutical compositions, and preparations comprising such transgene constructs. Method of uses of such transgene constructs and associated compositions are also disclosed herein.
A significant challenge in medical diagnostics is the often- sequential nature of various diagnostic modalities, for example, x-rays and ultrasounds. Systems and methods for using a machine learning model to analyze a sequence of scans to account for sequential information are provided herein. A system may receive a sequence of scans. The system may determine a subsequence of scans including a subset of scans from the sequence of scans. The system may determine an incremental prediction, using a machine learning model, based on the subsequence of scans. When the system determines all scans of the sequence are included in the subsequence, the system may determine an overall prediction based on one or more of the incremental predictions.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
The technology described herein is directed to immune modulatory agents and methods of use. In some aspects, described herein are agents that modulate IL-17a/IL-17 receptor-induced signalling and/or IL-17f/IL-17 receptor-induced signalling and associated methods of use thereof. In some aspects, described herein are agents that modulate TNF-α/TNF receptor signalling and associated methods of use thereof.
A61K 31/438 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle le cycle étant condensé en spiro avec des systèmes carbocycliques ou hétérocycliques
A61K 31/416 - 1,2-Diazoles condensés avec des systèmes carbocycliques, p. ex. indazole
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/473 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. acridines, phénantridines
A61K 31/5386 - 1,4-Oxazines, p. ex. morpholine condensées en spiro ou formant une partie de systèmes cycliques pontés
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
The present disclosure provides, in some aspects, nucleic acid-based molecular tools that enable the recording of molecular structure and soluble signals as well as the programmed assembly of molecular structures.
C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
C12N 15/64 - Méthodes générales pour la préparation du vecteur, pour son introduction dans la cellule ou pour la sélection de l'hôte contenant le vecteur
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6809 - Méthodes de détermination ou d’identification des acides nucléiques faisant intervenir la détection différentielle
C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
C12Q 1/6853 - Réactions d’amplification d’acides nucléiques utilisant des amorces ou des matrices modifiées
41.
ENGINEERING OF SYSTEMS, METHODS AND OPTIMIZED GUIDE COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR-Cas system.
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA-targeting systems comprising a novel DNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA. Methods for making and using and uses of such systems, methods, and compositions and products from such methods and uses are also disclosed and claimed.
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing business information in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Downloadable mobile applications for use in the distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content for business leaders; Downloadable podcasts in the field of of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Downloadable electronic publications in the nature of e-books, case studies, journals, articles and magazines in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Printed books in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed catalogs in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed articles in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed magazines in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed journals in the field of business, management, management, entrepreneurship, news, politics, and workplace issues Providing on-line digital publications in the nature of books, articles, case studies, e-zines, journals and blogs in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues via the Internet; Providing a website featuring blogs and non-downloadable publications in the nature of videos and podcasts in the field(s) of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Production of podcasts; Publishing of books, magazines; Publishing of web magazines; Publishing of electronic publications; Publication of books, journals, pamphlets, textbooks, case studies, magazines, e-zines, online journals, and articles in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing podcasts in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing instruction and training in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Conducting distance learning instruction at the undergraduate level; Conducting distance learning instruction at the graduate level; Conducting distance learning instruction at the post-graduate level; Education services, namely, providing on-line interactive exercises in the nature of educational exams, homework assignments, course materials, testing, and educational presentations in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Platform as a service (PAAS) featuring computer software platforms for providing users with access to media content in the field of business, management, and entrepreneurship; Providing subscription-based temporary use of non-downloadable cloud-based software for providing users with access to media content in the field of business, management, and entrepreneurship; Computer services, namely, creating an on-line community for registered users to participate in discussions, get feedback from their peers, form virtual communities, and engage in social networking services in the field of business, management, and entrepreneurship; Providing temporary use of non-downloadable cloud-based software for distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content; Providing temporary use of non-downloadable cloud-based software for artificial intelligence (AI) for mentoring and tutoring the user in the field of business, management, and entrepreneurship
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing business information in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Downloadable mobile applications for use in the distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content for business leaders; Downloadable podcasts in the field of of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Downloadable electronic publications in the nature of e-books, case studies, journals, articles and magazines in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Printed books in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed catalogs in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed articles in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed magazines in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed journals in the field of business, management, management, entrepreneurship, news, politics, and workplace issues Providing on-line digital publications in the nature of books, articles, case studies, e-zines, journals and blogs in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues via the Internet; Providing a website featuring blogs and non-downloadable publications in the nature of videos and podcasts in the field(s) of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Production of podcasts; Publishing of books, magazines; Publishing of web magazines; Publishing of electronic publications; Publication of books, journals, pamphlets, textbooks, case studies, magazines, e-zines, online journals, and articles in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing podcasts in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing instruction and training in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Conducting distance learning instruction at the undergraduate level; Conducting distance learning instruction at the graduate level; Conducting distance learning instruction at the post-graduate level; Education services, namely, providing on-line interactive exercises in the nature of educational exams, homework assignments, course materials, testing, and educational presentations in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Platform as a service (PAAS) featuring computer software platforms for providing users with access to media content in the field of business, management, and entrepreneurship; Providing subscription-based temporary use of non-downloadable cloud-based software for providing users with access to media content in the field of business, management, and entrepreneurship; Computer services, namely, creating an on-line community for registered users to participate in discussions, get feedback from their peers, form virtual communities, and engage in social networking services in the field of business, management, and entrepreneurship; Providing temporary use of non-downloadable cloud-based software for distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content; Providing temporary use of non-downloadable cloud-based software for artificial intelligence (AI) for mentoring and tutoring the user in the field of business, management, and entrepreneurship
45.
COMPOSITIONS AND METHODS FOR INHIBITING STAG1 EXPRESSION AND USES THEREOF
Described herein are compositions and methods for downregulating the expression of Stromal Antigen 1 (STAG1). The compositions described comprise antisense oligonucleotides (ASOs) having sequences sufficiently complementary to a portion of a STAG1 primary transcript. Compositions comprising ASOs described can be used for the treatment of cancer, including cohesin-deficient cancers and STAG2-deficient cancers.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/502 - PyridazinesPyridazines hydrogénées condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. cinnoline, phtalazine
A61K 31/551 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole ayant deux atomes d'azote comme hétéro-atomes d'un cycle, p. ex. clozapine, dilazèpe
A61P 35/02 - Agents anticancéreux spécifiques pour le traitement de la leucémie
46.
METHODS OF PRODUCING MULTI-LAYERED TUBULAR TISSUE CONSTRUCTS
A61L 27/28 - Matériaux pour le revêtement de prothèses
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
Provided herein are CRISPR-Cas9 PAM variant enzymes, methods of using the same, and machine-learning based methods of identifying variant enzymes with desired PAM specificity or activity.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services, namely, providing online course,
instruction in the fields of medicine and health care
regarding the U.S. health care system, global health care
delivery, digital transformation in health care, payer
dynamics, drug discovery, the pharmaceutical industry,
medical device development and the reimbursement system.
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided.
A61K 38/50 - Hydrolases (3) agissant sur des liaisons carbone-azote autres que des liaisons peptidiques (3.5), p. ex. asparaginase
A61K 47/61 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique le composé organique macromoléculaire étant un polysaccharide ou l’un de ses dérivés
C12N 9/64 - Protéinases provenant de tissu animal, p. ex. rennine
C12N 9/78 - Hydrolases (3.) agissant sur les liaisons carbone-azote autres que les liaisons peptidiques (3.5)
C12N 15/01 - Préparation de mutants sans introduction de matériel génétique étrangerProcédés de criblage à cet effet
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12P 19/34 - Polynucléotides, p. ex. acides nucléiques, oligoribonucléotides
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
50.
ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and methods related to components of a CRISPR complex particularly comprising a Cas ortholog enzyme.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 9/96 - Stabilisation d'une enzyme par formation d'un adduct ou d'une compositionFormation de conjugaisons d'enzymes
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
C12N 15/85 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules animales
A spectrally selective tiling system for inducing or reducing non-visual responses to light, including direct alerting responses and resetting of a human circadian clock, comprising at least one partition having alternatingly angled surfaces including (a) angled surfaces having a blue-enriched color, each configured to face a first direction and to reflect light incident from the first direction, and (b) angled surfaces having a blue-depleted color, each configured to face a second direction distinct from the first direction and to reflect light incident from the second direction.
A61M 21/02 - Autres dispositifs ou méthodes pour amener un changement dans l'état de conscienceDispositifs pour provoquer ou arrêter le sommeil par des moyens mécaniques, optiques ou acoustiques, p. ex. pour mettre en état d'hypnose pour provoquer le sommeil ou la relaxation, p. ex. par stimulation directe des nerfs, par hypnose ou par analgésie
E04B 2/74 - Cloisons mobiles ne supportant pas de chargeCloisons à bord supérieur libre
G02F 1/01 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur
52.
METHODS, KITS, SYSTEMS AND COMPOSITIONS FOR MULTIPLEX DETECTION OF TARGETS
The disclosure provides methods, composition, kits and systems for detecting, quantifying, and/or imaging target molecules, e.g., biomolecules, in a sample such as a preparation of cells or tissue.
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
Provided herein are methods and compositions for treating cancer or a tumor in a subject by administering to the subject T cells with reduced RGMb expression or activity and an immune checkpoint inhibitor such as a PD-1 or PD-L1 inhibitor.
C12N 5/0783 - Cellules TCellules NKProgéniteurs de cellules T ou NK
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 31/497 - Pyrazines non condensées contenant d'autres hétérocycles
A61K 31/7076 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle contenant des pyrimidines condensées ou non-condensées contenant des purines, p. ex. adénosine, acide adénylique
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07H 19/167 - Radicaux purine avec un ribosyle comme radical saccharide
Devices, systems, and methods that use a structure are provided. The structure may include a waveguide layer and an intrinsically stressed thin film. The waveguide layer may include a first material. The intrinsically stressed thin film may include a second material. The intrinsically stressed thin film may be disposed on the waveguide layer, thereby inducing a strain in the waveguide layer. The first material may include at least one color center having a first pair and/or second pair of energy levels or quantum states having an optical energy separation and/or a second pair of energy levels or quantum states having a microwave energy separation. The optical energy separation and the microwave energy separation of the pair of energy levels and/or quantum states may be determined by the induced strain.
Described herein is a method of forming an aligned tissue or tissue construct. The method includes extruding a bioink material through a nozzle onto a support to form a structure of the bioink material, the bioink material comprising anisotropic organ building blocks (aOBBs) comprising extracellular matrix material (ECM) and cellularly aligned cells, wherein the aOBBs align parallel to the direction of the extrude path, and polymerizing the structure of the bioink material, thereby forming the tissue or tissue construct having arbitrarily programmed alignment. Also, described is a tissue or tissue construct produced by the method, as well as bioink material used to produce the same.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
The present invention provides a single-membrane pH-decoupling redox flow batteries (e.g., aqueous redox flow batteries) that employ electrolytes of differing pH to develop a cell with high round-trip energy efficiency at an open-circuit voltage greater than the voltage for water splitting. Further, the invention provides an acid-base regeneration system to restore the negolyte and posolyte pHs to their initial values to compensate for any long-term acid/base crossover.
H01M 10/05 - Accumulateurs à électrolyte non aqueux
H01M 10/056 - Accumulateurs à électrolyte non aqueux caractérisés par les matériaux utilisés comme électrolytes, p. ex. électrolytes mixtes inorganiques/organiques
H01M 4/02 - Électrodes composées d'un ou comprenant un matériau actif
60.
SYSTEM AND METHOD FOR PRODUCTION OF HYDROGEN PEROXIDE
The present invention generally relates, in some aspects, to articles and methods relating to nanosensors for determination of molecules and other features, e.g., via surface plasmonic resonance, electric resonance, magnetic resonance, color changes, or the like. These articles and methods may be used, for example, for sample detection. The articles described in some aspects of the invention include a microwell array and a nanosensor array. In some embodiments, the nanosensor arrays may utilize nanoparticles positioned on nanostructures that are able to interact with a sample suspected of containing an analyte, such as a single cell. The interaction between nanoparticles and a sample can be detected by a change in applied energy, such as altered electromagnetic radiation caused by surface plasmonic resonance of incident visible light, and/or other types of resonance. Electromagnetic radiation may be applied to a microwell array and nanosensor, and the applied electromagnetic radiation may be altered as a nanosensor interacts with a sample suspected of containing an analyte. In addition, in some embodiments, the nanosensor arrays may utilize nanostructures and the binding of analytes may be determined based on optical or color changes.
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
The invention provides for systems, methods, and compositions for targeting and editing nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a RNA-targeting Cas13 protein, at least one guide molecule, and at least one adenosine deaminase protein or catalytic domain thereof.
The present invention generally relates to microfluidics and labeled nucleic acids. Certain aspects are generally directed to containing cells in gels, such as agarose gels, and determining nucleic acids within the cells, e.g., while contained within the gels. The nucleic acids may be, for example, genomic DNA, mRNA, transcriptomes, or the like. In some embodiments, for instance, both genomic DNA and RNA (e.g., as in a transcriptome) from a cell may be determined. In some cases, the nucleic acids may be attached to beads for sequencing or other purposes. Such systems may be useful, for example, for high-throughput sequencing or other applications.
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.
Wearable devices protect against musculoskeletal injuries and enhance performance. Systems and methods provide wearable devices to assist with human motion during physical activities, such as performing movements (e.g., lifting) and holding static poses (e.g., crouching, or holding a tool while working overhead). Materials, constructions, and system architectures allow the wearable devices to be worn over, under, or integrated into clothing for extended periods of time to improve performance or reduce risk of injury. Sensors may be included in the wearable devices to detect various activities, motions, and postures of the wearer, and various active and semi-active controls approaches may leverage sensor information to provide tailored assistance to individual users. Various controls optimization techniques ensure the wearable devices operate at peak efficiency.
A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles
The invention provides batteries, e.g., flow batteries, and methods of cycling the batteries that reduce loss of capacity. The loss of capacity of may be mitigated by employing a mixture of redox active species.
H01M 8/18 - Éléments à combustible à régénération, p. ex. batteries à flux REDOX ou éléments à combustible secondaires
H01M 8/20 - Éléments à combustible indirects, p. ex. éléments à combustible avec un couple REDOX irréversible
H01M 8/04223 - Dispositions auxiliaires, p. ex. pour la commande de la pression ou pour la circulation des fluides pendant le démarrage ou l’arrêtDépolarisation ou activation, p. ex. purgeMoyens pour court-circuiter les éléments à combustible défectueux
67.
METHODS AND COMPOSITIONS FOR PRODUCING OOGONIA-LIKE CELLS
Provided herein are methods and compositions for differentiating induced pluripotent stem cells into oogonia-like cells by overexpressing transcription factors such as ZNF281, LHX8, and/or SOHLH1.
The present disclosure provides arrestin domain-containing protein 1 (ARRDC1)-mediated microvesicles (ARMMs) modified with Nipah virus (NiV) glycoproteins fused to antibodies or antigen-binding fragments and NiV fusion proteins, and variants thereof. The ARMMs of the present disclosure may be targeted to particular cell types and used to deliver agents (e.g., therapeutic agents) to target cells. Microvesicle-producing cells are also provided by the present disclosure. The present disclosure also provides methods of delivering molecules to target cells using the ARMMs described herein, and methods of treating a patient using any of the ARMMs or microvesicle-producing cells provided herein. Kits comprising any of the ARMMs or microvesicle-producing cells described herein are also provided by the present disclosure.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 35/17 - LymphocytesLymphocytes BLymphocytes TCellules tueuses naturellesLymphocytes activés par un interféron ou une cytokine
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
69.
METHODS AND COMPOSITIONS FOR PRODUCING PRIMORDIAL GERM CELL-LIKE CELLS
Provided herein are methods and compositions for differentiating induced pluripotent stem cells into primordial germ cell-like cells by overexpressing transcription factors such as DLX5, HHEX, and/or FIGLA.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
70.
METHODS FOR SCREENING FOR NEXT GENERATION NUCLEIC ACID DELIVERY VECTORS
The technology described herein is directed to compositions and methods for delivery of nucleic acids to cells of interest, e.g., in vivo. Methods are described for the identification of viral envelope sequences that mediate infection or transduction of a target cell type using virus-like particles in a high-throughput manner. The methods and compositions described herein permit the delivery of, e.g., RNA encoding therapeutic polypeptides and/or gene editing machinery to cells of interest. Such delivery can be in a manner that limits, avoids or circumvents accumulation in or clearance of the delivery vehicles by the liver.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C12N 15/64 - Méthodes générales pour la préparation du vecteur, pour son introduction dans la cellule ou pour la sélection de l'hôte contenant le vecteur
C40B 20/04 - Identification des éléments d'une bibliothèque au moyen d'une étiquette, d'un marqueur ou d'un autre identificateur lisible ou détectable, p. ex. procédés de décodage
C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
71.
METHODS AND COMPOSITIONS FOR INDUCING IMMUNE SYSTEM TOLERANCE
This disclosure relates to methods and compositions for the delivery of antigens to host cells for the induction of immune system tolerance. Methods and compositions described herein are useful in the treatment of diseases caused by or relating to immune system dysfunction, including but not limited to autoimmune disorders.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
A61K 38/00 - Préparations médicinales contenant des peptides
72.
METHODS AND COMPOSITIONS FOR PRODUCING GRANULOSA-LIKE CELLS
Provided herein are methods and compositions for differentiating induced pluripotent stem cells into granulosa-like cells by overexpressing transcription factors such as NR5A1 and a RUNX family protein (e.g., RUNX1 and/or RUNX2).
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
The present disclosure relates to spatially modulating the light source used in microscopy. In some cases, a light source projects a sequence of two-dimensional spatial patterns onto a sample using a spatial light modulator. In some cases, the spatial patterns are based on Hadamard matrices. In some cases, an imaging device captures frames of image data in response to light emitted by the sample and orthogonal components of the image data are analyzed by cross-correlating the image data with the spatial pattern associated with each frame. A microscope may be calibrated by illuminating a sample with the sequence of spatial patterns, capturing image data, and storing calibration that maps each pixel of the spatial light modulator to at least one pixel of the imaging device.
G06T 7/521 - Récupération de la profondeur ou de la forme à partir de la télémétrie laser, p. ex. par interférométrieRécupération de la profondeur ou de la forme à partir de la projection de lumière structurée
G06T 7/80 - Analyse des images capturées pour déterminer les paramètres de caméra intrinsèques ou extrinsèques, c.-à-d. étalonnage de caméra
A system for the treatment of pain comprising: at least one muscle graft in contact with: an epineural window of a target nerve, and/or a terminus of a target nerve; and at least one electrode.
A61N 1/36 - Application de courants électriques par électrodes de contact courants alternatifs ou intermittents pour stimuler, p. ex. stimulateurs cardiaques
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
75.
NONVOLATILE MEMORY DEVICE AND OPERATING METHOD OF THE SAME
Samsung Electronics Co., Ltd. (République de Corée)
President and Fellows Of Harvard College (USA)
Inventeur(s)
Lee, Minhyun
Jang, Houk
Ham, Donhee
Liu, Chengye
Hinton, Henry
Kim, Haeryong
Shin, Hyeonjin
Abrégé
A nonvolatile memory device includes a resistance switching layer, a gate on the resistance switching layer, a gate oxide layer between the resistance switching layer and the gate, and a source and a drain, spaced apart from each other, on the resistance switching layer. A resistance value of the resistance switching layer is changed based on an illumination of light irradiated onto the resistance switching layer and is maintained as a changed resistance value.
H10N 70/00 - Dispositifs à l’état solide n’ayant pas de barrières de potentiel, spécialement adaptés au redressement, à l'amplification, à la production d'oscillations ou à la commutation
H10B 63/00 - Dispositifs de mémoire par changement de résistance, p. ex. dispositifs RAM résistifs [ReRAM]
76.
ELECTROPHILIC REACTIVE LINKERS FOR LABELING OF POLYPEPTIDES AND METHODS OF USE THEREOF
1112122 are linking molecules. Molecules according to the present invention find use, for example, in multifunctional chimeric molecules (e.g., bifunctional molecules), which make substrate modifications such as post-translational modifications to targets that are not the natural substrate; accordingly, diseases or disorders may be treated or prevented with molecules of the present disclosure.
C07K 14/35 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de bactéries provenant de Mycobacteriaceae (F)
The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel. For example, a droplet may be hardened to form a gel, where the droplet contains a cell, DNA, or other suitable species. The gel may be exposed to a reactant, and the reactant may interact with the gel and/or with the cell, DNA, etc., in some fashion. For example, the reactant may diffuse through the gel, or the hardened particle may liquefy to form a liquid state, allowing the reactant to interact with the cell. As the DNA is amplified using PCR, some of the DNA will be bound to the gel via the PCR primer.
Disclosed herein are methods for generating mature cardiomyocytes and compositions including mature cardiomyocytes. Also disclosed herein are methods for enhancing maturation of quiescent cardiomyocytes and compositions including mature quiescent cardiomyocytes.
Provided are isolated, cloned enhancer element sequences that target certain neuronal cell types, subtypes, and/or populations in the brain and CNS. The isolated and cloned enhancer elements can target a gene of interest, such as a therapeutic gene or an effector gene, to be expressed in the certain cell types. Virus vectors containing the isolated, cloned enhancer element sequences, particularly, recombinant adeno-associated virus (rAAV) vectors, and a gene or polynucleotide to be expressed in a given neuronal cell type are described. The rAAV vectors, compositions and methods are useful for treating subjects afflicted with neuropsychiatric and neuropathological diseases, disorders and conditions and symptoms thereof.
The present disclosure generally relates to certain image-based techniques for detecting nucleic acids and proteins in a sample. The methods provided include simultaneous detection of RNAs and proteins using RCA-MERFISH technology.
In one aspect, a specimen holder includes a first end configured to attach to a cooling device and a second end configured to be inserted into a microscope; a section with a sample tip at the second end; an interface between the first end configured to attach to the cooling device and the section with the sample tip; and an internal thermal connection section configured to be in thermal contact with a cold finger of the cooling device when the specimen holder is attached to the cooling device and extending through the section with the sample tip to the sample tip.
Various aspects of the instant disclosure relate to a nanostructured agrichemical delivery vehicle. The vehicle has a core-shell structure. The core includes a first polymeric material. The shell at least partially encases the core. The shell includes a second polymeric material. The core, the shell, or both include an agrichemical component distributed about the first polymeric material, the second polymeric material, or both. The release of the agrichemical component from the core, the shell or both is triggered by exposure to at least one of a predetermined enzyme, a predetermined pH, a predetermined biotic secretion, a predetermined temperature, a predetermined moisture content, a predetermined light source.
The J. David Gladstone Institutes, a testamentary trust established under the will of J. David (USA)
President and Fellows of Harvard College (USA)
Inventeur(s)
Shipman, Seth
Abrégé
Engineered retrons, modified to enhance production of multicopy single-stranded DNA (msDNA), are provided. In addition, vector systems encoding such engineered retrons and methods of using engineered retrons and vector systems encoding them in various applications such as CRISPR/Cas-mediated genome editing, recombineering, cellular barcoding, and molecular recording are also disclosed.
C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
85.
METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME, AND FRAGILE X SYNDROME
The present invention features a method of reducing tactile dysfunction or anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett Syndrome, or Fragile X syndrome by administering a GABAA agent having reduced blood brain barrier or by expressing a nucleic acid encoding an exogenous alpha or beta subunit of a GABAA receptor in dorsal root ganglion neurons in the subject using a vector.
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/36 - Composés contenant des groupes méthylènedioxyphényle, p. ex. sésamine
A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
A61K 31/4465 - Pipéridines non condensées, p. ex. pipérocaïne substituées uniquement en position 4
A61K 31/4535 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un hétérocycle avec le soufre comme hétéro-atome du cycle, p. ex. pizotifène
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
In a method for controlling translocation of a target polymer molecule through a nanopore, a clamp is reversibly bound at a site along the target polymer molecule length; the clamp and the target polymer molecule are disposed in an ionic solution that is in fluidic communication with a nanopore having an aperture diameter less than an outer diameter of the clamp. A constant translocation force is applied across the nanopore to induce travel of the target polymer molecule into the nanopore such that the reversibly bound clamp abuts the nanopore. A voltage pulse is applied across the nanopore that advances the target polymer molecule into the nanopore by one nucleotide, without either of chemical fuel and biochemical fuel provided to the clamp. The voltage pulse is repeatedly applied to cause a plurality of nucleotides to translocate through the nanopore. An indication of each nucleotide can be acquired during nucleotide translocation.
Provided herein are compounds, such as compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, and compositions, methods, uses, and kits thereof. The compounds provided herein are DDR1, DDR2, or p38 MAPK (e.g., p38-alpha) inhibitors and are therefore useful for the treatment and/or prevention of various diseases and conditions (e.g., inflammatory diseases, joint diseases, proliferative diseases, fibrosis, or pain).
This invention provides zwitterionic compounds and polymers. The zwitterionic compounds and polymers have applications in soft robotics as actuators, in electronics as circuit components, and in energy storage as an electrolyte.
C07C 311/31 - Sulfonamides, le squelette carboné de la partie acide étant substitué de plus par des atomes d'azote liés par des liaisons simples, ne faisant pas partie de groupes nitro ou nitroso ayant les atomes de soufre des groupes sulfonamide liés à des atomes de carbone acycliques
C07C 311/32 - Sulfonamides, le squelette carboné de la partie acide étant substitué de plus par des atomes d'azote liés par des liaisons simples, ne faisant pas partie de groupes nitro ou nitroso ayant les atomes de soufre des groupes sulfonamide liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé
C07C 311/36 - Sulfonamides, le squelette carboné de la partie acide étant substitué de plus par des atomes d'azote liés par des liaisons simples, ne faisant pas partie de groupes nitro ou nitroso ayant l'atome de soufre d'au moins un des groupes sulfonamide lié à un atome de carbone d'un cycle autre qu'un cycle aromatique à six chaînons
C07C 311/37 - Sulfonamides, le squelette carboné de la partie acide étant substitué de plus par des atomes d'azote liés par des liaisons simples, ne faisant pas partie de groupes nitro ou nitroso ayant l'atome de soufre d'au moins un des groupes sulfonamide lié à un atome de carbone d'un cycle aromatique à six chaînons
The present invention generally relates to systems and methods for producing nucleic acids. In some aspects, relatively large quantities of oligonucleotides can be produced, and in some cases, the oligonucleotides may have a variety of different sequences and/or lengths. For instance, a relatively small quantity of oligonucleotides may be amplified to produce a large amount of nucleotides. In one set of embodiments, oligonucleotides may be amplified using PCR, then transcribed to produce RNA. The RNA may then be reverse transcribed to produce DNA, and optionally, the RNA may be selectively degraded or removed, relative to the DNA. In one set of embodiments, the oligonucleotides may be chemically modified. These modifications may include, but are not limited, to the adding of fluorescent dyes or other signaling entities.
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/6816 - Tests d’hybridation caractérisés par les moyens de détection
C12Q 1/6837 - Couplage enzymatique ou biochimique d’acides nucléiques à une phase solide utilisant des réseaux de sondes ou des puces à sondes
G06N 7/01 - Modèles graphiques probabilistes, p. ex. réseaux probabilistes
G16B 25/00 - TIC spécialement adaptées à l’hybridationTIC spécialement adaptées à l’expression de gènes ou de protéines
G16B 25/20 - Réaction en chaîne par polyméraseConception d’amorces ou de sondesOptimisation de la sonde
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
G16B 40/10 - Traitement du signal, p. ex. de spectrométrie de masse ou de réaction en chaîne par polymérase
G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
91.
ISOLATION AND DIAGNOSTIC METHODS USING CELL TYPE-SPECIFIC AND/OR ORGAN-SPECIFIC EXTRACELLULAR VESICLE (EV) MARKERS
The present invention relates to novel biomarkers and combinations thereof for cell type-specific and/or organ-specific extracellular vesicles, in particular, brain-specific and/or neuron-specific extracellular vesicles. The present invention also provides methods for isolation and/or enrichment of cell type-specific and/or organ-specific extracellular vesicles, methods for identification of extracellular vesicles derived from a cell, and methods for diagnosing or prognosing a disorder, e.g., a neurodegenerative disorder, using the cell type specific and/or organ-specific extracellular vesicles. Compositions in the form of kits of reagents for detecting the cell type-specific and/or organ-specific extracellular vesicles are also provided.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
92.
Method of Selectively Sequencing Amplicons in a Biological Sample
A61H 23/02 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles à entraînement électrique ou magnétique
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
G01C 19/00 - GyroscopesDispositifs sensibles à la rotation utilisant des masses vibrantesDispositifs sensibles à la rotation sans masse en mouvementMesure de la vitesse angulaire en utilisant les effets gyroscopiques
G01P 15/14 - Mesure de l'accélérationMesure de la décélérationMesure des chocs, c.-à-d. d'une variation brusque de l'accélération en utilisant un gyroscope
G01P 3/44 - Dispositifs caractérisés par l'utilisation de moyens électriques ou magnétiques pour mesurer la vitesse angulaire
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
Produits et services
Providing business information in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Providing on-line digital publications in the nature of books, articles, case studies, e-zines, journals and blogs in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues via the Internet; Providing a website featuring blogs and non-downloadable publications in the nature of videos and podcasts in the field(s) of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Production of podcasts; Publishing of books, magazines; Publishing of web magazines; Publishing of electronic publications; Publication of books, journals, pamphlets, textbooks, case studies, magazines, e-zines, online journals, and articles in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing podcasts in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing instruction and training in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Conducting distance learning instruction at the undergraduate level; Conducting distance learning instruction at the graduate level; Conducting distance learning instruction at the post-graduate level; Education services, namely, providing on-line interactive exercises in the nature of educational exams, homework assignments, course materials, testing, and educational presentations in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Platform as a service (PAAS) featuring computer software platforms for providing users with access to media content in the field of business, management, and entrepreneurship; Providing subscription-based temporary use of non-downloadable cloud-based software for providing users with access to media content in the field of business, management, and entrepreneurship; Computer services, namely, creating an on-line community for registered users to participate in discussions, get feedback from their peers, form virtual communities, and engage in social networking services in the field of business, management, and entrepreneurship; Providing temporary use of non-downloadable cloud-based software for distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content; Providing temporary use of non-downloadable cloud-based software for artificial intelligence (AI) for mentoring and tutoring the user in the field of business, management, and entrepreneurship Downloadable mobile applications for use in the distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content for business leaders; Downloadable podcasts in the field of of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Downloadable electronic publications in the nature of e-books, case studies, journals, articles and magazines in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Printed books in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed catalogs in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed articles in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed magazines in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed journals in the field of business, management, management, entrepreneurship, news, politics, and workplace issues
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
09 - Appareils et instruments scientifiques et électriques
16 - Papier, carton et produits en ces matières
Produits et services
Providing business information in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Providing on-line digital publications in the nature of books, articles, case studies, e-zines, journals and blogs in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues via the Internet; Providing a website featuring blogs and non-downloadable publications in the nature of videos and podcasts in the field(s) of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Production of podcasts; Publishing of books, magazines; Publishing of web magazines; Publishing of electronic publications; Publication of books, journals, pamphlets, textbooks, case studies, magazines, e-zines, online journals, and articles in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing podcasts in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Education services, namely, providing instruction and training in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Conducting distance learning instruction at the undergraduate level; Conducting distance learning instruction at the graduate level; Conducting distance learning instruction at the post-graduate level; Education services, namely, providing live and on-line interactive exercises in the nature of educational exams, homework assignments, course materials, testing, and educational presentations in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Platform as a service (PAAS) featuring computer software platforms for providing users with access to media content in the field of business, management, and entrepreneurship; Providing subscription-based temporary use of non-downloadable cloud-based software for providing users with access to media content in the field of business, management, and entrepreneurship; Computer services, namely, creating an on-line community for registered users to participate in discussions, get feedback from their peers, form virtual communities, and engage in social networking services in the field of business, management, and entrepreneurship; Providing temporary use of non-downloadable cloud-based software for distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content; Providing temporary use of non-downloadable cloud-based software for artificial intelligence (AI) for mentoring and tutoring the user in the field of business, management, and entrepreneurship Downloadable mobile applications for use in the distribution of educational and training materials in the form of digital publications, digital video, video files, and multimedia content for business leaders; Downloadable podcasts in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues; Downloadable electronic publications in the nature of e-books, case studies, journals, articles and magazines in the field of business, management, leadership, entrepreneurship, news, politics, and workplace issues Printed catalogs in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed books in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed articles in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed magazines in the field of business, management, management, entrepreneurship, news, politics, and workplace issues; Printed journals in the field of business, management, management, entrepreneurship, news, politics, and workplace issues
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
(1) Educational services, namely, providing instruction and training in the nature of courses of instruction and training classes in the fields of medicine and health; educational services, namely, conducting distance learning instruction and training at the undergraduate, graduate, and post-graduate levels; educational services, namely, dissemination, in the nature of providing, online interactive exercises, namely, educational exams, homework assignments, course material testing, and educational presentations, as part of an online course of instruction, in the fields of medicine and health.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
(1) Educational services, namely, providing online course, instruction in the fields of medicine and health care regarding the U.S. health care system, global health care delivery, digital transformation in health care, payer dynamics, drug discovery, the pharmaceutical industry, medical device development and the reimbursement system.
98.
MULTIPLEX FLUORESCENT CELLULAR AND TISSUE IMAGING WITH DNA ENCODED THERMAL CHANNELS AND USES THEREOF
C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
Devices, systems, and methods related to autonomous directional valves that allow fluids to stop and flow based on progressive changes in pressure are generally described.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 3/06 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus avec des moyens de filtration, d'ultrafiltration, d'osmose inverse ou de dialyse
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (Suisse)
Inventeur(s)
Feldmann, Sascha
Reponen, Antti-Pekka M.
Mattes, Marcel
Abrégé
A luminescence spectroscopy apparatus for time-resolved characterization of a sample emitting circularly polarized light is described, comprising a pulsed laser excitation source configured to generate a laser pulse for exciting the sample, an achromatic quarter-wave plate arranged to receive therethrough light emitted by the sample, a polarization beam splitter arranged downstream to the quarter-wave plate, an optical spectrometer arranged downstream to the polarization beam splitter, a time-gated intensified charge-coupled device arranged to receive light from the optical spectrometer and comprising an image intensifier, and a controller configured to control a pulse generator to apply a gate pulse to the image intensifier for selectively activating the image intensifier, wherein the controller is connected to the pulsed laser excitation source such that the gate pulse is triggerable by the laser pulse of the pulsed laser excitation source.
