Abrégé

A polypeptide for repairing a skin wound or a mucosal injury, having obvious effects of alleviating the pathological development of acute and chronic gastrointestinal diseases, promoting repair of a skin wound or a mucosal injury, treating tumors, etc.; and use of the polypeptide in repairing a skin wound or a mucosal injury. By blocking or activating FGF/FGFR1 signaling, the polypeptide capable of binding to an FGFR1 receptor is capable of inhibiting or promoting cell proliferation, vascular hyperplasia, collagen formation, etc.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides

Abrégé

The invention relates to a polypeptide and use thereof in treating stroke and other neurological injury-related diseases or use thereof in health care products.

Classes IPC  ?

• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
• A61P 9/00 - Médicaments pour le traitement des troubles du système cardiovasculaire
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides

Abrégé

Provided is a new polypeptide. The new polypeptide shows a significant effect of relieving intestinal lumen distension in pharmacodynamic tests of a Brachydanio Rerio inflammatory bowel disease model and a rat inflammatory bowel disease model, and can be used for preparing a drug for treating enteritis, especially ulcerative colitis.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• C07K 5/10 - Tétrapeptides
• C07K 5/103 - Tétrapeptides la chaîne latérale du premier amino-acide étant acyclique, p. ex. Gly, Ala
• C07K 5/11 - Tétrapeptides la chaîne latérale du premier amino-acide contenant plus de groupes amino que de groupes carboxyle, ou leurs dérivés, p. ex. Lys, Arg
• C07K 5/113 - Tétrapeptides la chaîne latérale du premier amino-acide contenant plus de groupes carboxyle que de groupes amino, ou leurs dérivés, p. ex. Asp, Glu, Asn
• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides

Abrégé

Provided is an application of a polypeptide in the preparation of a product for preventing or treating skin injury diseases. The polypeptide is Pro-Ala-Ala-Glu-Pro-Val-Pro-Leu or a physiologically compatible salt thereof.

Classes IPC  ?

• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides

Abrégé

Provided are a new polypeptide for repairing mucosal damage or a skin wound, and the use thereof. The polypeptide is not homologous with known polypeptides, can be stably present in vivo and in vitro, and has the effect of regulating stem cell proliferation and differentiation to repair mucosal damage or a skin wound. The present invention further relates to the use of the new polypeptide in the repairing of mucosal damage or a skin wound by means of regulating stem cell proliferation and differentiation, and the use thereof in the prevention, alleviation or treatment of gastrointestinal diseases.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 1/02 - Préparations stomatologiques, p. ex. médicaments pour le traitement des caries, des aphtes, des périodontites
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• C07K 5/103 - Tétrapeptides la chaîne latérale du premier amino-acide étant acyclique, p. ex. Gly, Ala
• C07K 5/117 - Tétrapeptides le premier amino-acide étant hétérocyclique, p. ex. Pro, His, Trp
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides

Abrégé

Provided is a new polypeptide. The new polypeptide shows a significant effect of relieving intestinal lumen distension in pharmacodynamic tests of a Brachydanio Rerio inflammatory bowel disease model and a rat inflammatory bowel disease model, and can be used for preparing a drug for treating enteritis, especially ulcerative colitis.

Classes IPC  ?

• C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
• C07K 5/00 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• C07K 7/00 - Peptides ayant de 5 à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• C07K 11/00 - Depsipeptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse

Abrégé

Provided is an application of a polypeptide in the preparation of a product for preventing or treating skin injury diseases. The polypeptide is Pro-Ala-Ala-Glu-Pro-Val-Pro-Leu or a physiologically compatible salt thereof.

Classes IPC  ?

• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques

Abrégé

A polypeptide for repairing a skin wound or a mucosal injury, having obvious effects of alleviating the pathological development of acute and chronic gastrointestinal diseases, promoting repair of a skin wound or a mucosal injury, treating tumors, etc.; and use of the polypeptide in repairing a skin wound or a mucosal injury. By blocking or activating FGF/FGFR1 signaling, the polypeptide capable of binding to an FGFR1 receptor is capable of inhibiting or promoting cell proliferation, vascular hyperplasia, collagen formation, etc.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires

Abrégé

The present invention provides novel polypeptides for repairing skin wounds or mucosal injuries, and applications thereof. A series of polypeptides of the present invention are not homologous to known polypeptides and have an effect of regulating cell proliferation and differentiation; the polypeptides are used for repairing mucosal injuries or skin wounds, and are used for preventing, relieving, or treating gastrointestinal diseases such as gastritis and gastric ulcer.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• C07K 5/103 - Tétrapeptides la chaîne latérale du premier amino-acide étant acyclique, p. ex. Gly, Ala
• C07K 5/083 - Tripeptides la chaîne latérale du premier amino-acide étant acyclique, p. ex. Gly, Ala
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61K 38/07 - Tétrapeptides
• A61K 38/06 - Tripeptides
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse

Abrégé

Provided are a new polypeptide for repairing mucosal damage or a skin wound, and the use thereof. The polypeptide is not homologous with known polypeptides, can be stably present in vivo and in vitro, and has the effect of regulating stem cell proliferation and differentiation to repair mucosal damage or a skin wound. The present invention further relates to the use of the new polypeptide in the repairing of mucosal damage or a skin wound by means of regulating stem cell proliferation and differentiation, and the use thereof in the prevention, alleviation or treatment of gastrointestinal diseases.

Classes IPC  ?

• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires

Produits et services

Cleansing milk for toilet purposes; cleaning preparations; polishing preparations; cosmetics; cosmetic preparations for skin care; mouthwashes, not for medical purposes; dentifrices; potpourris [fragrances]; cosmetics for animals; air fragrancing preparations. Vitamin preparations; medicines for human purposes; crude drug; disinfectants; dietetic substances adapted for medical use; nutritional supplements; medicines for veterinary purposes; disinfectant wipes; pre-filled bags containing medicinal health care preparations; teeth filling material. Massage apparatus; medical apparatus and instruments; apparatus for use in medical analysis; dental apparatus and instruments; physiotherapy apparatus; furniture especially made for medical purposes; contraceptives, non-chemical; surgical implants comprised of artificial materials; orthopaedic articles; suture materials.

Produits et services

(1) Publicity agency namely advertising agency services; presentation of goods on communication media, for retail purposes namely business management of retail and online stores; commercial administration of the licensing of the goods and services of others; providing business marketing information for others; business marketing consulting services; provision of an on-line marketplace for buyers and sellers of goods and services; personnel management consultancy; web indexing for commercial or advertising purposes; rental of vending machines; rental of sales stands; retail services for pharmaceutical, veterinary and sanitary preparations and medical supplies; wholesale services for pharmaceutical, veterinary and sanitary preparations and medical supplies; drug retail or wholesale services; pharmaceutical preparations retail or wholesale services; retail or wholesale services for medical supplies; veterinary drugs retail or wholesale services;

Produits et services

(1) Cleansing milk for toilet purposes; all purpose cleaning preparations; polishing creams; cosmetics; cosmetic preparations for skin care; mouthwashes, not for medical purposes; dentifrices; potpourris [fragrances]; cosmetics for animals; air fragrancing preparations. (2) Vitamin preparations; preparations for treating colds; pharmaceutical products for treating respiratory diseases; pharmaceutical preparations and substances for the treatment of gastro-intestinal diseases; crude drug namely cod liver oil; all-purpose disinfectants; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; nutritional supplements for general health and well-being; pain relief medication for veterinary purposes; sanitizing wipes; filled first-aid boxes; teeth filling material. (3) Vibrators massagers; medical apparatus and instruments for general examination; diabetes monitoring equipment for sampling and analyzing blood and body tissue; dental instruments; physiotherapy apparatus namely high frequency electromagnetic therapy apparatus; massage beds for medical purposes; contraceptives, non-chemical; medical, surgical and orthopaedic implants made of artificial materials; orthopaedic belts; suture materials.

Produits et services

(1) Nutritional supplements for general health and well-being; Vitamin preparations in the form of meal replacement drinks and powders; Nutritional supplements for building body mass; Botanical supplements for general health and well-being; Herbal supplements for general health and well-being; Vitamin enhanced water; Vitamin preparations; Anti-infectives; Anti-inflammatories; Antibiotics; Antivirals; Anti-cough drops; Pharmaceutical preparations for the treatment of skin irritations, namely bee stings, sunburn, rashes, sores, corns, calluses, and acne; Preparations for cleansing the skin for medical use; Pharmaceutical preparations for the treatment of bacterial skin infections, fungal skin infections, viral skin infections and parasitic skin infections; Burn dressings; Dietary supplements for general health and well-being.

Produits et services

(1) Nutritional supplements for general health and well-being; Vitamin preparations in the form of meal replacement drinks and powders; Nutritional supplements for building body mass; Botanical supplements for general health and well-being; Herbal supplements for general health and well-being; Vitamin enhanced water; Vitamin preparations; Anti-infectives; Anti-inflammatories; Antibiotics; Antivirals; Anti-cough drops; Pharmaceutical preparations for the treatment of skin irritations, namely bee stings, sunburn, rashes, sores, corns, calluses, and acne; Preparations for cleansing the skin for medical use; Pharmaceutical preparations for the treatment of bacterial skin infections, fungal skin infections, viral skin infections and parasitic skin infections; Burn dressings; Dietary supplements for general health and well-being.

Abrégé

periplaneta americana extract in preparation for a medicine used for preventing and treating radiation-induced damages. The medicine is capable of preventing and treating the damages caused by radiation therapy for nasopharyngeal cancer, esophageal cancer, stomach cancer, lung cancer, liver cancer, breast cancer, waldeyer's lymphoma, and other cancers. Through test verification, the medicine of the present invention has an obvious prevention and treatment effect for damages caused by radiation therapy for patients with breast tumors and breast cancer after surgery.

Classes IPC  ?

• A61K 35/64 - Insectes, p. ex. abeilles, guêpes ou puces
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 35/63 - Arthropodes

Produits et services

Dietetic foods adapted for medical purposes; medicinal drinks; dietetic substances adapted for medical use; dietetic beverages adapted for medical purposes; vitamin preparations; medicines for human purposes; tonics [medicines].

Produits et services

Dietetic foods adapted for medical purposes; medicinal drinks; dietetic substances adapted for medical use; dietetic beverages adapted for medical purposes; vitamin preparations; medicines for human purposes; tonics [medicines].

Produits et services

Dietetic foods, namely, pasta, adapted for medical use; medicinal drinks; dietetic foods, namely, crackers, adapted for medical use; dietary supplemental drinks in the nature of vitamin and mineral beverages; vitamin preparations; prescription and non-prescription medicines for the prevention and treatment of cold and flu, and for the treatment of damaged skin and tissue, intestinal disorders, cardiovascular disorders, ocular disorders or diseases, bacteria-based diseases or disorders, autoimmune diseases or disorders, kidney diseases or disorders, and diabetes

Abrégé

Disclosed is a preparation method of periplaneta americana extract, which comprises the following steps: (1) obtaining periplaneta americana coarse powder, adding water to make a mass-to-volume ratio between the periplaneta americana coarse powder and the water be 25:6-14, performing flash extracting for two to three times and 1-3min for each time under a voltage condition of 80-120 volt to obtain extraction liquid; (2) centrifugalizing the extraction liquid obtained in step (1), obtaining a supernatant and carrying out concentration to obtain the periplaneta americana extract.

Classes IPC  ?

• A61K 35/64 - Insectes, p. ex. abeilles, guêpes ou puces
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• A61P 9/02 - Cardiotoniques non-spécifiques, p. ex. médicaments pour le traitement des syncopes, antihypotenseurs
• A61P 9/04 - Agents inotropes, c.-à-d. stimulants de la contraction cardiaqueMédicaments pour le traitement de l'insuffisance cardiaque
• A61P 9/06 - Antiarythmiques
• A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale

Abrégé

Disclosed are a Periplaneta americana extract and the preparation method therefor. The method uses acetone for reflux and water for extraction. The resulting extract is concentrated, to which ethanol is added, then ethanol is recovered to obtain a filtrate. The filtrate is then processed through an adsorption resin column, and the effluent liquid is collected until the ninhydrin reaction is negative. The liquid is processed through a polyamide column, and the effluent liquid is collected until the ninhydrin reaction is negative. The effluent liquid is concentrated and dried. Also disclosed is the use of the Periplaneta americana extract in the manufacture of an inductive solution for orientedly inducing the differentiation from mesenchyme stem cells to epidermal cells.

Classes IPC  ?

• A61K 35/64 - Insectes, p. ex. abeilles, guêpes ou puces
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains

Abrégé

A composition for preparing a cream of Periplaneta americana extract comprises the following proportions by weight of components: 2-20 parts of glycerol, 3-6 parts of triethanolamine, 10-14 parts of stearic acid, 12-24 parts of liquid paraffin, 4-16 parts of paraffin, and 20-69 parts of water. A cream of Periplaneta americana extract is a formulation prepared by combining a Periplaneta americana extract as an active component with excipients. Proportions by weight of the Periplaneta americana extract to the excipients are: 0.5-3 parts of Periplaneta americana extract, 2-20 parts of glycerol, 3-6 parts of triethanolamine, 10-14 parts of stearic acid, 12-24 parts of liquid paraffin, 4-16 parts of paraffin, and 20-69 parts of water.

Classes IPC  ?

• A61K 35/64 - Insectes, p. ex. abeilles, guêpes ou puces
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires

Abrégé

The present invention relates to the technical field of chemically synthesized drugs, and in particular, to an acyclic nucleotide analogue, a preparation method therefor, and an application thereof in an antiviral drug. A technical problem to be solved by the present invention is to provide a novel acyclic nucleotide analogue, having a structure represented by formula (I). The acyclic nucleotide analogue of the present invention has an antiviral efficacy and provides a new choice for the development of antiviral drugs.

Classes IPC  ?

• C07D 487/04 - Systèmes condensés en ortho
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
• A61P 31/20 - Antiviraux pour le traitement des virus ADN