05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; Pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Pharmaceuticals and biopharmaceutical products for human use, used to maintain health or restore health in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Biological preparations for human use, in the nature of microorganisms, namely bacteria, fungi, yeasts, protozoa, archaea, algae, and bacteriophages, used to maintain health or restore health in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Medicinal infusions for human use, used for the treatment, to maintain health and to restore health in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases
(2) Drug delivery devices, namely a drug delivery set comprising medical tubing and infusion bags for administering fluids to patients rectally
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; Pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases and infectious diseases; Pharmaceutical and biopharmaceutical products, for human use, used to maintain health or restore health in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases and infectious diseases; Biological preparations in the nature of microorganisms, namely bacteria, fungi, yeasts, protozoa, archaea, and bacteriophages, for human use, used to maintain health or restore health in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases and infectious diseases; Medicinal infusions, for human use, used for the treatment, to maintain health and to restore health in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases and infectious diseases.
3.
COMPOSITIONS USED IN COMBINATION WITH IMMUNE MODULATORY TREATMENTS FOR TREATING CANCERS
The present invention relates to the field of anticancer treatments. In particular, the present invention concerns therapeutic compositions for use in combination with immune modulatory treatments (IMTs) for treating cancers. The present invention also concerns kits of parts comprising said compositions and immune modulatory treatments. The present invention further concerns in vitro methods for screening said compositions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction, and for treating cancers and diseases, namely, neurological, psychiatric, gastrointestinal, metabolic, inflammatory, autoimmune, and infectious diseases; Pharmaceuticals for treatment, maintaining and restoring human health in the field of disturbed microbial community, and treatment for dysbiosis, cancers, and diseases, in the nature of neurological, psychiatric, gastrointestinal, metabolic, inflammatory, autoimmune, and infectious diseases; Biological preparations in the nature of microorganisms used to treat, maintain and restore human health in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, and diseases in the nature of neurological, psychiatric, gastrointestinal, metabolic, inflammatory, autoimmune, and infectious diseases Medical and surgical apparatus and instruments for use in gastrointestinal surgery; drug delivery devices in the nature of medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations, namely, a kit comprising a suspension bag and administration tube set, sold empty; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, namely, syringes, infusion sets, implantable devices sold empty; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set sold without medication
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and
preparations for the medical treatment of gastrointestinal
diseases and disorders emanating from microbiota
dysfunction; pharmaceutical and biopharmaceutical products
and preparations used for the treatment of cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases;
pharmaceuticals used to maintain health or restore health to
a human subject in the field of treatment of a disturbed
microbial community, namely, for the treatment of dysbiosis,
cancers, neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases;
biological preparations in the nature of microorganisms used
to maintain health or restore health to a human subject in
the field of treatment of a disturbed microbial community,
namely, for the treatment of dysbiosis, cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases. Medical and surgical apparatus and instruments; drug
delivery devices, including medical apparatus and
instruments for administration of pharmaceutical and
biopharmaceutical products and preparations; drug delivery
devices to treat gut microbiome-related disorders, cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases; drug
delivery devices to treat gut microbiome-related disorders,
cancers, neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases, in the
nature of a kit comprising a prefilled suspension bag and
administration tube set.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and
preparations for the medical treatment of gastrointestinal
diseases and disorders emanating from microbiota
dysfunction; pharmaceutical and biopharmaceutical products
and preparations used for the treatment of cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases;
pharmaceuticals used to maintain health or restore health to
a human subject in the field of treatment of a disturbed
microbial community, namely, for the treatment of dysbiosis,
cancers, neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases;
biological preparations in the nature of microorganisms used
to maintain health or restore health to a human subject in
the field of treatment of a disturbed microbial community,
namely, for the treatment of dysbiosis, cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases. Medical and surgical apparatus and instruments; drug
delivery devices, including medical apparatus and
instruments for administration of pharmaceutical and
biopharmaceutical products and preparations; drug delivery
devices to treat gut microbiome-related disorders, cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases; drug
delivery devices to treat gut microbiome-related disorders,
cancers, neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases, in the
nature of a kit comprising a prefilled suspension bag and
administration tube set.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and
preparations for the medical treatment of gastrointestinal
diseases and disorders emanating from microbiota
dysfunction; pharmaceutical and biopharmaceutical products
and preparations used for the treatment of cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases;
pharmaceuticals used to maintain health or restore health to
a human subject in the field of treatment of a disturbed
microbial community, namely, for the treatment of dysbiosis,
cancers, neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases;
biological preparations in the nature of microorganisms used
to maintain health or restore health to a human subject in
the field of treatment of a disturbed microbial community,
namely, for the treatment of dysbiosis, cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases. Medical and surgical apparatus and instruments; drug
delivery devices, including medical apparatus and
instruments for administration of pharmaceutical and
biopharmaceutical products and preparations; drug delivery
devices to treat gut microbiome-related disorders, cancers,
neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases; drug
delivery devices to treat gut microbiome-related disorders,
cancers, neurological diseases, psychiatric diseases,
gastrointestinal diseases, metabolic diseases, inflammatory
diseases, autoimmune diseases, infectious diseases, in the
nature of a kit comprising a prefilled suspension bag and
administration tube set.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; Pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases. Medical and surgical apparatus and instruments; drug delivery devices, including medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases.
(2) Medical and surgical apparatus and instruments; drug delivery devices, including medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases Medical and surgical apparatus and instruments for use in gastrointestinal surgery; drug delivery devices in the nature of medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations, namely, a kit comprising a suspension bag and administration tube set, sold empty; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, namely, syringes, infusion sets, implantable devices sold empty; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set sold without medication
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases Medical and surgical apparatus and instruments for use in gastrointestinal surgery; drug delivery devices in the nature of medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations, namely, a kit comprising a suspension bag and administration tube set, sold empty; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, namely, syringes, infusion sets, implantable devices sold empty; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set sold without medication
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases Medical and surgical apparatus and instruments for use in gastrointestinal surgery; drug delivery devices in the nature of medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations, namely, a kit comprising a suspension bag and administration tube set, sold empty; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, namely, syringes, infusion sets, implantable devices sold empty; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set sold without medication
13.
FECAL MICROBIOTA COMPOSITION FOR USE IN REDUCING TREATMENT-INDUCED INFLAMMATION
The invention relates to the use of fecal microbiota transplant for preventing and/or reducing systemic and gut treatment-induced inflammation in an individual in need thereof.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Consulting services in the field of engineering, namely, evaluations and assessments in the fields of science and technology provided by engineers; scientific research and technical research in the field of biomarkers, nutrition, microbiotherapy, bacteriotherapy, metagenomics, metabolomics, transcriptomics, fluxomics and therapies meant to have an effect on the gut microbiota functions; scientific research services for medical purposes; research and development of new products for others; technical project studies, namely, engineering services in the nature of technical project planning for the manufacture, control and traceability of pharmaceutical products having an effect on gut microbiota or biomarkers aiming at characterizing the gut microbiota; chemical analysis; chemistry services, namely, laboratory research in the field of chemistry; Scientific research in the nature of conducting clinical trials for others; engineering in the nature of surveying work; engineering; scientific laboratory services; scientific research in biology, bacteriology, chemistry and physics; scientific research in the field of microbiotherapy; scientific and technical research and analysis for the characterization of the genetics fingerprint of the human intestinal microbiota; Providing online non-downloadable computer software for designing, identifying, monitoring and validating medical treatment of gut dysbiosis related diseases; Providing online non-downloadable computer software to monitor drug development and manufacturing; Providing online non-downloadable computer software to stratify patients for ulterior treatments; Providing online non-downloadable computer software to study diseases and identify biomarkers Medical and veterinary services; health services, namely, medical evaluation services for the purpose of guiding treatment; medical treatment services, namely, medical treatment of gut dysbiosis related diseases; digestive-system disease medical treatment services, namely, medical treatment of digestive-system diseases; medical services provided in the field of microbiotherapy; medical assistance; health counseling services; pharmacy advice, namely, pharmaceutical consultation; blood bank services; medical equipment rental; hospital services; nursing home services; pharmacists' services, namely, preparation of prescriptions by pharmacists; Medical therapeutic services, namely, therapeutic transplantation of gut to preserve the gut symbiosis; physiotherapy; telemedicine services, namely, virtual medical consultation about biomarkers used to characterize the gut microbiota
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; veterinary preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; microorganism-based preparations for medical or veterinary use; bacterial preparations for medical or veterinary use; pharmaceutical and biopharmaceutical products and preparations comprising microorganism by-products, meaning enzymes, metabolites, spores, vesicles, nucleic acids and other small chemical compounds for human or veterinary use; microbiotherapy preparations for medical use for intestinal microbiome repair; cultures of microorganisms and biological tissue cultures for medical or veterinary use; Biological preparations for medical use for fecal transplantation or microbiome ecosystem therapies for restoring the intestinal microbiota; food and beverages comprising microorganisms or microorganism by-products adapted for medical or veterinary use, food supplements for humans and animals; medical plasters, materials for dressings, namely, lint for medical purposes Medical and surgical apparatus and instruments for use in gastrointestinal surgery; drug delivery devices, in the nature of medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations in humans and animals, namely,. oral delivery capsules, suppositories, syringes, infusion sets and medical tubing, implantable devices, sold empty; Drug delivery devices to treat gut microbiome-related disorders, in the nature of a kit comprising a prefilled suspension bag and administration tube set sold without medication; enema apparatus for delivery of microorganism-based or microorganism by-products-based compositions and preparations; medical apparatus for fecal transplantation for restoring the intestinal microbiota; diagnostic apparatus for medical use, namely, diagnostic apparatus for medical diagnostic testing in the field of gut microbiota related diseases; testing apparatus for medical use, namely, apparatus for medical diagnostic testing in the field of gut dysbiosis related diseases; Medical diagnostic apparatus, namely, intestinal microbiota analysis apparatus for medical use; blood testing apparatus
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; Pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases. Medical and surgical apparatus and instruments; drug delivery devices, including medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; Pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases. Medical and surgical apparatus and instruments; drug delivery devices, including medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biopharmaceutical products and preparations for the medical treatment of gastrointestinal diseases and disorders emanating from microbiota dysfunction; Pharmaceutical and biopharmaceutical products and preparations used for the treatment of cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Pharmaceuticals used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; Biological preparations in the nature of microorganisms used to maintain health or restore health to a human subject in the field of treatment of a disturbed microbial community, namely, for the treatment of dysbiosis, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases. Medical and surgical apparatus and instruments; drug delivery devices, including medical apparatus and instruments for administration of pharmaceutical and biopharmaceutical products and preparations; Drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases; drug delivery devices to treat gut microbiome-related disorders, cancers, neurological diseases, psychiatric diseases, gastrointestinal diseases, metabolic diseases, inflammatory diseases, autoimmune diseases, infectious diseases, in the nature of a kit comprising a prefilled suspension bag and administration tube set.
19.
METHOD OF PREDICTING AND THEN PRODUCING A MIX OF MICROBIOTA SAMPLES
Prediction of a mix of complex communities of microorganisms includes a linear prediction, e.g. matrix-based, that is corrected using an interaction model, e.g. a matrix, learnt from reference true mix profiles and corresponding reference linear-predicted profiles. Reverse prediction makes it possible to determine a mix of samples to be made given a target mix profile.
G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
20.
DETERMINATION OF MICROBIOTA SAMPLES TO PRODUCE A TARGET MIX PRODUCT AND PREDICTION OF MIXES
An evolutionary algorithm is used to determine parameters of a production process of a complex microorganism community, CMC, product given a target profile for the CMC product. CMC mixing operation and co-cultivation operation of a CMC product are modelled, using learnt matrix-based models. The evolutionary algorithm iteratively modify candidates representing the parameters, including a set of complex microorganism community samples in the initial sample collection and mixing ratios for one or more mixing operations in the production process. The determined set of samples and associated mixing ratios are then used to control actual picking and processing of complex microorganism community samples according to the mix production process, to obtain a CMC product as close as possible, in terms of profiling features, to the target profile.
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
INISTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIORNNEMENT (France)
Inventeur(s)
Affagard, Hervé
Schwintner, Carole
Verdier, Cécile
Denis, Sylvain
Brugere, Jean-François
Alric, Monique
Abrégé
A method of expanding a complex community of microorganisms is provided, an expanded complex community of microorganisms obtained by the method is provided, a pharmaceutical formulation comprising the expanded complex community of microorganisms is provided, and the use of the expanded complex community of microorganisms and the pharmaceutical formulation is provided.
The present disclosure relates to a method for assessing whether a GVHD subject in need of a complementation with live microorganisms can benefit from said complementation, by analysing the subject’s microbiota and/or host parameters. Treatments for improving the status of patients identified as poor microbiotherapy responders are also provided, as well as materials and kits for performing the method according to the invention.
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
23.
METHOD OF PREDICTING AND THEN PRODUCING A MIX OF MICROBIOTA SAMPLES
Prediction of a mix of complex communities of microorganisms includes a linear prediction, e.g. matrix-based, that is corrected using an interaction model, e.g. a matrix, learnt from reference true mix profiles and corresponding reference linear-predicted profiles. Reverse prediction makes it possible to determine a mix of samples to be made given a target mix profile.
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France)
Inventeur(s)
Affagard, Hervé
Schwintner, Carole
Verdier, Cécile
Denis, Sylvain
Brugere, Jean-François
Alric, Monique
Abrégé
The present invention concerns a method of expanding a complex community of microorganisms, an expanded complex community of microorganisms obtained by said method, a pharmaceutical formulation comprising said expanded complex community of microorganisms and the use of said expanded complex community of microorganisms and said pharmaceutical formulation.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Biological indicators for measuring the inflammatory
potential of a bacterial composition; bacteriological
preparations for pharmaceutical use; bacteriological
preparations for medical use; bacteriological culture
mediums for medical use; culture media for bacteriology;
pharmaceutical and veterinary products; microbiotherapy
preparations for medical use for intestinal microbiome
repair. Biological analyses; preparation of biological samples for
testing and analysis in research laboratories; evaluations
and assessments in the fields of science and technology
provided by engineers; biological research laboratory
services; research in biology, bacteriology and chemistry;
scientific research in the field of microbiotherapy.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Indicateurs biologiques pour la mesure du potentiel inflammatoire d'une composition bactérienne; préparations bactériologiques à usage pharmaceutique destinées à agir sur le microbiote intestinal; préparations bactériologiques à usage médical à savoir préparations de microbiothérapie pour la réparation du microbiome intestinal ; bouillons de culture pour la bactériologie; produits pharmaceutiques et vétérinaires destinés à agir sur le microbiote intestinal; préparations de microbiothérapie à usage médical pour la réparation du microbiome intestinal. (1) Analyses biologiques nommément analyse des prélèvements de fluides biologiques issus du corps ; préparation d'échantillons biologiques pour tests et analyses dans des laboratoires de recherche; évaluations et estimations dans les domaines scientifiques et technologiques rendues par des ingénieurs nommément évaluation de la conception et du développement de produits médicaux et méthodes d'analyse; services de laboratoires de recherches biologiques relatives aux maladies liées au microbiote intestinal; recherches en biologie relatives aux thérapies ayant un effet sur le microbiote intestinal, en bactériologie et en chimie; recherches scientifiques dans le domaine de la microbiothérapie.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Biological indicators for measuring the inflammatory potential of a bacterial composition for medical purposes; bacteriological preparations for pharmaceutical use; bacteriological preparations for medical use; bacteriological culture mediums for medical use; culture media for bacteriology; pharmaceutical and veterinary products, namely, preparations for the treatment of gut dysbiosis related diseases; microbiotherapy preparations for medical use for intestinal microbiome repair Biological analyses; preparation of biological samples for testing and analysis in research laboratories; evaluations and assessments in the fields of science and technology provided by engineers; biological research laboratory services; scientific research in biology, bacteriology and chemistry; scientific research in the field of microbiotherapy
The invention relates to a container for the lyophilisation of a liquid or semi-liquid product. The container comprises an upper portion (2) provided with a membrane which is permeable to water vapour and a lower portion (3) comprising a reservoir designed to receive the product on a bottom. The container comprises internal partitions (21) in the reservoir (19) which form a plurality of product-receiving volumes (22-27), the internal partitions (21) being configured such that introducing product into one of the predefined receiving volumes (22) causes said receiving volumes (22-27) to be successively filled in a predetermined order.
F26B 5/06 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide le procédé impliquant la congélation
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary products; food supplements
for humans and animals; dietary supplements for humans and
animals, namely nutritional supplements; dietary
supplements for humans and animals, namely dietetic food and
substances for medical or veterinary use; chemical
preparations for medical or pharmaceutical use; chemical
preparations for pharmaceutical or medical use, namely
microbiotherapy preparations for intestinal microbiome
repair; bacteriological preparations for medical or
veterinary use; bacterial preparations for medical or
veterinary use; biological preparations for medical or
veterinary use; culture media for bacteriology;
chemico-pharmaceutical products; microbiotherapy
preparations for medical use for intestinal microbiome
repair. Evaluations and assessments in the fields of science and
technology provided by engineers; scientific and technical
research; research and development of new products for
third parties; technical project studies; chemical
analysis; chemistry services; clinical trials; surveying
[engineering work]; scientific laboratory services;
research in biology, bacteriology, chemistry and physics;
scientific research in the field of microbiotherapy.
30.
FMT PERFORMANCE PREDICTION TEST TO GUIDE AND OPTIMIZE THERAPEUTIC MANAGEMENT OF GVHD PATIENTS
The present disclosure relates to a method for assessing whether a GVHD subject in need of a complementation with live microorganisms can benefit from said complementation, by analysing the subject's microbiota and/or host parameters. Treatments for improving the status of patients identified as poor microbiotherapy responders are also provided, as well as materials and kits for performing the method according to the invention.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE (France)
Inventeur(s)
Schwintner, Carole
Affagard, Hervé
Dore, Joël
Abrégé
A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: —collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (IO) of the container (5), —and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
G01N 1/20 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide pour matériau coulant ou s'éboulant
The invention relates to the use of fecal microbiota transplant for preventing and/or reducing systemic and gut treatment-induced inflammation in an individual in need thereof.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary products, namely, preparations for the treatment of gut dysbiosis related diseases; chemical preparations for medical or pharmaceutical use, namely, for the treatment of gut dysbiosis related diseases; chemical preparations for pharmaceutical or medical use, namely microbiotherapy preparations for intestinal microbiome repair; bacteriological preparations for medical or veterinary use; bacterial preparations for medical or veterinary use; biological preparations for medical or veterinary use; culture media for bacteriology; chemico-pharmaceutical products, namely, for the treatment of gut dysbiosis related diseases; microbiotherapy preparations for medical use for intestinal microbiome repair Evaluations and assessments in the fields of science and technology provided by engineers; scientific and technical research in the field of biomarkers, nutrition, microbiotherapy, bacteriotherapy, and therapies meant to have an effect on the gut microbiota functions; research and development of new products for third parties; technical project studies, namely, engineering services in the nature of technical project planning for the manufacture, control and traceability of pharmaceutical products having an effect on gut microbiota or biomarkers aiming at characterizing the gut microbiota; chemical analysis; chemistry services, namely, laboratory research in the field of chemistry; conducting clinical trials for others; surveying engineering work; scientific laboratory services; research in biology, bacteriology, chemistry and physics; scientific research in the field of microbiotherapy
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Produits pharmaceutiques et vétérinaires destinées à agir sur le microbiote intestinal pour la prévention et le traitement des cancers, des maladies neurologiques, des maladies psychiatriques, des maladies gastro-intestinales, des maladies métaboliques, des maladies inflammatoires, des maladies auto-immunes et des maladies infectieuses ; compléments alimentaires pour animaux nommément ferments bactériens pour la prévention et le traitement des cancers, des maladies neurologiques, des maladies psychiatriques, des maladies gastro-intestinales, des maladies métaboliques, des maladies inflammatoires, des maladies auto-immunes et des maladies infectieuses ; compléments alimentaires pour animaux, à savoir compléments nutritionnels nommément ferments bactériens pour la prévention et le traitement des cancers, des maladies neurologiques, des maladies psychiatriques, des maladies gastro-intestinales, des maladies métaboliques, des maladies inflammatoires, des maladies auto-immunes et des maladies infectieuses ; compléments alimentaires pour animaux, à savoir aliments et substances diététiques à usage vétérinaire sous forme de gélules, de capsules, de comprimés, de barres, de tablettes, de sachets, de liquides, de gelées, de poudres à base d'acides aminés, de minéraux, de sels minéraux, de vitamines et de protéines, destinés à agir sur le microbiote intestinal pour la prévention et le traitement des cancers, des maladies neurologiques, des maladies psychiatriques, des maladies gastro-intestinales, des maladies métaboliques, des maladies inflammatoires, des maladies auto-immunes et des maladies infectieuses ; préparations chimiques à usage médical ou pharmaceutique nommément préparations chimiques pour agir sur une dysbiose intestinale pour la prévention et le traitement des cancers, des maladies neurologiques, des maladies psychiatriques, des maladies gastro-intestinales, des maladies métaboliques, des maladies inflammatoires, des maladies auto-immunes et des maladies infectieuses; préparations chimiques à usage médical ou pharmaceutique, à savoir préparations de microbiothérapie pour la réparation du microbiome intestinal; préparations bactériologiques à usage médical ou vétérinaire à savoir préparations de microbiothérapie pour la réparation du microbiome intestinal; préparations bactériennes à usage médical ou vétérinaire à base de microbiote intestinal; préparations biologiques à usage médical ou vétérinaire destinées à agir sur le microbiote intestinal pour la prévention et le traitement des cancers, des maladies neurologiques, des maladies psychiatriques, des maladies gastro-intestinales, des maladies métaboliques, des maladies inflammatoires, des maladies auto-immunes et des maladies infectieuses; bouillons de culture pour la bactériologie; produits chimico-pharmaceutiques pour la réparation du microbiome intestinal; préparations de microbiothérapie à usage médical pour la réparation du microbiome intestinal. (1) Evaluations et estimations dans les domaines scientifiques et technologiques rendues par des ingénieurs nommément évaluation de la conception et du développement de produits médicaux; recherches scientifiques et techniques nommément recherche dans le domaine de la biotechnologie, recherche dans le domaine de la médecine, des biomarqueurs, de la nutrition, de la microbiothérapie, de la bactériothérapie, et des thérapies ayant un effet sur le microbiote intestinal; recherche et développement de nouveaux produits pour des tiers; études de projets techniques nommément analyses de projets techniques dans le domaine de la biotechnologie et de la médecine; analyse chimique; services de conseillers en chimie; essais cliniques; expertises [travaux d'ingénieurs] nommément expert-conseil en génie chimique; services de laboratoires scientifiques nommément laboratoires chimiques, services de laboratoire médical, services de recherche en laboratoire dans le domaine de l'expression génétique, services de recherche médicale en laboratoire; recherches en biologie, en bactériologie, en chimie, en physique; recherches scientifiques dans le domaine de la microbiothérapie.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Evaluations et estimations dans les domaines scientifiques et technologiques rendues par des ingénieurs, nommément évaluation de la conception et du développement de produits médicaux ; recherches scientifiques et techniques, nommément recherche dans le domaine de la biotechnologie, recherche dans le domaine de la médecine, des biomarqueurs, de la nutrition, de la microbiothérapie, de la bactériothérapie, et des thérapies ayant un effet sur le microbiote intestinal ; recherche et développement de nouveaux produits pour des tiers ; études de projets techniques, nommément analyses de projets techniques dans le domaine de la biotechnologie et de la médecine ; analyse chimique ; services de conseillers en chimie ; essais cliniques ; expertises [travaux d'ingénieurs], nommément expert-conseil en génie chimique ; ingénierie chimique ; services de laboratoires scientifiques, nommément laboratoires chimiques, services de laboratoire médical, services de recherche en laboratoire dans le domaine de l'expression génétique, du microbiote intestinal, services de recherche médicale en laboratoire ; recherches et analyses scientifiques et techniques aux fins de caractérisation de l'empreinte génétique du microbiote intestinal humain.
(2) Services médicaux et vétérinaires des maladies liées au microbiote intestinal; services de santé, nommément services d'examens médicaux en matière de traitement de maladies et troubles digestifs liés à la dysbiose intestinale; services de traitements médicaux des maladies liés à la dysbiose intestinale; services de traitements des maladies de l'appareil digestif, nommément services d'examens médicaux en matière de traitement de maladies et troubles digestifs liés à la dysbiose intestinale et services de soins de santé dans le domaine des maladies liés à la dysbiose intestinale; services médicaux rendus dans le domaine de la microbiothérapie, nommément consultation médicale et services de laboratoire dans le domaine de la microbiothérapie pour traiter les maladies liés à la dysbiose intestinale; assistance médicale, nommément fournir des informations médicales aux patients dans le domaine de la prévention, du dépistage, du diagnostic et du traitement des maladies et troubles digestifs liés à la dysbiose intestinale; consultation en matière de pharmacie; services de banque de sang; location d'équipements médicaux; services hospitaliers; maisons médicalisées; services de pharmaciens [préparation d'ordonnances]; services thérapeutiques, nommément réadaptation thérapeutique, services de thérapie génique; physiothérapie; services de télémédecine.
36.
Method for detecting bacteria according to the gram signal thereof in a complex sample
The invention relates to a method for detecting the proportion of Gram-positive and Gram-negative bacteria in a complex sample. The bacteria are detected according to the Gram signal thereof. The invention enables distinction between species of Gram-positive bacteria and species of Gram-negative bacteria in a complex sample. The invention also relates to a kit for marking Gram-positive and Gram-negative bacteria, particularly for use in flow cytometry, particularly for complex samples such as human or animal microbiota samples.
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L' ALIMENTATION ET L'ENVIRONMENT (France)
Inventeur(s)
Affagard, Hervé
Schwintner, Carole
Juste, Catherine
Dore, Joël
Lepage, Patricia
Maillet, Christei
Rabot, Sylvie
Fonseca, Fernanda
Blottiere, Hervé
Abrégé
The present invention relates to a method for preparing a fecal 5 micro biota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline IO solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between −15° C. and −100° C. Steps b) to e) are carried out in anaerobiosis.
The present invention relates to a method for preparing a homogeneous mixture of fecal microbiota from at least two preselected donors. The homogeneous mixture of fecal microbiota thus obtained has a bacterial diversity and an increased viability. The homogeneous mixture of fecal microbiota may be used for treating intestinal dysbiosis and for treating pathologies associated with such dysbiosis.
The pharmaceutical oral formulation is especially designed to be delivered principally in the ileum and colon and to maintain the sample bacterial viability and diversity.
The invention relates to a container for the lyophilisation of a liquid or semi-liquid product. The container comprises an upper portion (2) provided with a membrane which is permeable to water vapour and a lower portion (3) comprising a reservoir designed to receive the product on a bottom. The container comprises internal partitions (21) in the reservoir (19) which form a plurality of product-receiving volumes (22-27), the internal partitions (21) being configured such that introducing product into one of the predefined receiving volumes (22) causes said receiving volumes (22-27) to be successively filled in a predetermined order.
F26B 5/06 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide le procédé impliquant la congélation
41.
FECAL MICROBIOTA COMPOSITION, FOR USE IN REDUCING TREATMENT-INDUCED INFLAMMATION
The invention relates to the use of fecal microbiota transplant for preventing and/or reducing systemic and gut treatment-induced inflammation in an individual in need thereof.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
The invention relates to a method for detecting the proportion of Gram-positive and Gram-negative bacteria in a complex sample. The bacteria are detected according to the Gram signal thereof. The invention enables distinction between species of Gram-positive bacteria and species of Gram-negative bacteria in a complex sample. The invention also relates to a kit for marking Gram-positive and Gram-negative bacteria, particularly for use in flow cytometry, particularly for complex samples such as human or animal microbiota samples.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
43.
STOOL COLLECTION METHOD AND SAMPLE PREPARATION METHOD FOR TRANSPLANTING FECAL MICROBIOTA
The present invention relates to a method for preparing a homogeneous mixture of fecal microbiota from at least two preselected donors. The homogeneous mixture of fecal microbiota thus obtained has a bacterial diversity and an increased viability. The homogeneous mixture of fecal microbiota may be used for treating intestinal dysbiosis and for treating pathologies associated with such dysbiosis.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
The present invention relates to a pharmaceutical oral formulation for use in the administration of at least two bacteria derived from fecal microbiota to mammals for the treatment and/or prevention of dysbiosis and associated pathologies. The pharmaceutical oral formulation is encapsulated mixture of at least two bacteria derived from fecal microbiota wherein the capsules are coated in a pH responsive polymer composition comprising: a.50-70% poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1 by weight of dry polymer, b.10-30% poly(methacrylic acid-co-ethyl acrylate) 1:1 by weight of dry polymer, c.at least one fatty acid mono-, di-or tri-glyceride ester, or mixtures thereof, d.at least one plasticizer, e.at least one non-ionic emulsifier. The pharmaceutical oral formulation is especially designed to be delivered principally in the ileum and colon and to maintain the sample bacterial viability and diversity.
A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
45.
Method of lyophilization of a sample of faecal microbiota
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (France)
Inventeur(s)
Affagard, Hervé
Schwintner, Carole
Juste, Catherine
Dore, Joël
Chapron, Audrey
Fonseca, Fernanda
David, Olivier
Abrégé
Method for lyophilisation of a simple of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than −50° C., preferably of between −70° C. and −100° C., followed by the lyophilisation thereof.
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
C12N 1/04 - Conservation des micro-organismes à l'état viable
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
46.
Microorganism sampling method, microorganism sampling device and sampling kit comprising such a sampling device
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (France)
Inventeur(s)
Schwintner, Carole
Affagard, Hervé
Dore, Joël
Abrégé
A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: —collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (10) of the container (5), —and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
05 - Produits pharmaceutiques, vétérinaires et hygièniques
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary products, namely, preparations for the treatment of gut dysbiosis related diseases; food supplements for humans and animals; dietary supplements for humans and animals, namely, nutritional supplements; dietary supplements for humans and animals, namely, dietetic food and beverages for medical or veterinary use; chemical preparations for medical or pharmaceutical use, namely, for the treatment of gut dysbiosis related diseases; chemical preparations for pharmaceutical or medical use, namely, microbiotherapy preparations for the repair of intestinal microbiome; bacteriological preparations for medical or veterinary use; bacterial preparations for medical or veterinary use; biological preparations for medical or veterinary use, namely for the treatment of gut dysbiosis related diseases; culture media for bacteriology; chemico-pharmaceutical preparations, namely, for the treatment of gut dysbiosis related diseases; microbiotherapy preparations for medical use for the repair of intestinal microbiome [ Education, namely classes, seminars, workshops, in the field of, microbiotherapy, bacteriology, gut microbiota and microbiome-based drugs; training in the field of microbiotherapy, bacteriology, gut microbiota and microbiome-based drugs; training, namely, organization and conducting of colloquiums, conferences, congresses, seminars in the field of microbiotherapy, bacteriology, gut microbiota and microbiome-based drugs; education, namely, arranging of exhibitions for educational purposes; training, namely, arranging and conducting workshops in the field of microbiotherapy, bacteriology, gut microbiota and microbiome-based drugs; training in the field of microbiotherapy ] [ Evaluations and assessments in the fields of science and technology provided by engineers; scientific and technical research in the field of biomarkers, nutrition, microbiotherapy, bacteriotherapy, and therapies meant to have an effect on the gut microbiota functions; research and development of new products for others; technical project studies namely, engineering services in the nature of technical project planning for the manufacture, control and traceability of pharmaceutical products having an effect on gut microbiota or biomarkers aiming at characterizing the gut microbiota; chemical analysis; chemistry services namely, laboratory research in the field of chemistry; conducting clinical trials for others; surveying engineering work; scientific laboratory services; research in biology, bacteriology, chemistry and physics; scientific research in the field of microbiotherapy ]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary products; medicines for human
medicine; chemical preparations for medical, pharmaceutical
or veterinary use; chemical preparations for pharmaceutical
or medical use, namely microbiotherapy preparations for
intestinal microbiome repair; bacteriological preparations
for medical or veterinary use; bacterial preparations for
medical or veterinary use; biological preparations for
medical or veterinary use; enzyme preparations for medical
or veterinary use; culture media for bacteriology;
chemico-pharmaceutical products; microbiotherapy
preparations for medical use for intestinal microbiome
repair; stem cells for medical or veterinary use; cultures
of microorganisms and biological tissues for medical or
veterinary use; diagnostic products for medical use;
digestives for pharmaceutical use; ferments for
pharmaceutical use; preparations for medical use for fecal
transplantation for restoring the intestinal microbiota;
sanitary products for medical purposes; dietetic food and
substances for medical or veterinary use, food for babies;
food supplements for humans and animals; plasters,
materials for dressings; material for dental fillings and
dental impressions; disinfectants; products for destroying
vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and
instruments; medical apparatus for fecal transplantation
for restoring the intestinal microbiota; diagnostic
apparatus for medical use; testing apparatus for medical
use; intestinal microbiota analysis apparatus for medical
use; blood testing apparatus; hypogastric belts;
dialyzers; drainage tubes for medical use; gastroscopes;
abdominal pads; injectors for medical use; enema apparatus
for medical use; artificial limbs, eyes and teeth;
orthopedic articles; suture material.
49.
METHOD FOR LYOPHILISATION OF A SAMPLE OF FECAL MICROBIOTA
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (France)
Inventeur(s)
Affagard, Hervé
Schwintner, Carole
Juste, Catherine
Dore, Joël
Chapron, Audrey
Fonseca, Fernanda
David, Olivier
Abrégé
Method for lyophilisation of a sample of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than -50°C, preferably of between -70°C and -100°C, followed by the lyophilisation thereof.
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Evaluations and assessments in the fields of science and
technology provided by engineers; scientific and technical
research; scientific research services for medical
purposes; research and development of new products for
others; technical project studies; chemical analysis;
chemistry services; clinical trials; surveying
[engineering work]; engineering; scientific laboratory
services; research in biology, bacteriology, chemistry and
physics; scientific research in the field of
microbiotherapy; scientific and technical research and
analysis for the characterization of the genetic fingerprint
of the human intestinal microbiota. Medical and veterinary services; health services; medical
treatment services; digestive-system disease treatment
services; medical services provided in the field of
microbiotherapy; medical assistance; health counseling
services; pharmacy advice; blood bank services; medical
equipment rental; hospital services; nursing homes;
pharmacists' services [preparation of prescriptions];
therapeutic services; physiotherapy; telemedicine services.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary products; food supplements
for humans and animals; dietary supplements for humans and
animals, namely nutritional supplements; dietary
supplements for humans and animals, namely dietetic food and
substances for medical or veterinary use; chemical
preparations for medical or pharmaceutical use; chemical
preparations for pharmaceutical or medical use, namely
microbiotherapy preparations for the repair of intestinal
microbiome; bacteriological preparations for medical or
veterinary use; bacterial preparations for medical or
veterinary use; biological preparations for medical or
veterinary use; culture media for bacteriology;
chemico-pharmaceutical products; microbiotherapy
preparations for medical use for the repair of intestinal
microbiome. Education; training; training, namely organization and
conducting of colloquiums, conferences, congresses,
seminars; education, namely arranging of exhibitions for
educational purposes; training, namely arranging and
conducting workshops; training in the field of
microbiotherapy. Evaluations and assessments in the fields of science and
technology provided by engineers; scientific and technical
research; research and development of new products for
others; technical project studies; chemical analysis;
chemistry services; clinical trials; surveying
[engineering work]; scientific laboratory services;
research in biology, bacteriology, chemistry and physics;
scientific research in the field of microbiotherapy.
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (France)
Inventeur(s)
Affagard, Hervé
Schwintner, Carole
Juste, Catherine
Dore, Joël
Lepage, Patricia
Maillet, Christel
Rabot, Sylvie
Fonseca, Fernanda
Blottiere, Hervé
Abrégé
The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between -15°C and -100°C. Steps b) to e) are carried out in anaerobiosis.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (France)
Inventeur(s)
Schwintner, Carole
Affagard, Hervé
Dore, Joël
Abrégé
A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: - collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (10) of the container (5), - and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Engineering evaluations and appraisals in the fields of science and technology; Scientific and technical research; Scientific research for medical purposes; Research and development for others; Technical project studies; Chemical analysis; Chemist services; Clinical trials; Surveying; Engineering services; Laboratory (Scientific -) services; Research in biology, bacteriology, chemistry, physics; Scientific research in the field of microbiotherapy; Scientific and technical research and analysis for the purposes of characterising the genetic fingerprint of the human intestinal microbiota. Medical and veterinary services; Medical services; Medical treatments; Treatment of diseases of the digestive system; Medical services provided in the field of microbiotherapy; Medical assistance; Advisory services relating to health; Pharmacy advice; Blood bank services; Medical equipment rental; Hospitals; Nursing home services; Pharmacists' services to make up prescriptions; Therapy services; Physical therapy; Telemedicine services.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and veterinary preparations; Medicines for human purposes; Chemical preparations for medical, pharmaceutical or veterinary purposes; Chemical preparations adapted for medical or pharmaceutical use, namely microbiotherapy preparations for repairing the intestinal microbiome; Bacteriological preparations for medical and veterinary use; Bacterial preparations for medical and veterinary use; Biological preparations for medical or veterinary purposes; Enzyme preparations for medical or veterinary purposes; Mediums (Bacteriological culture -); Chemico-pharmaceutical preparations; Microbiotherapy preparations adapted for medical use for repairing the intestinal microbiome; Stem cells for medical or veterinary purposes; Cultures of microorganisms and biological tissue for medical or veterinary purposes; Diagnostic preparations for medical purposes; Digestives for pharmaceutical purposes; Ferments for pharmaceutical purposes; Preparations for medical purposes used for faecal transplantation, for restoring the intestinal microbiota; Sanitary preparations for medical purposes; Dietetic food and substances adapted for medical or veterinary use, food for babies; Dietary supplements for humans and animals; Plasters, materials for dressings; Material for stopping teeth, dental wax; Disinfectants; Preparations for destroying vermin; Fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments; Medical apparatus for faecal transplantation, for restoring the intestinal microbiota; Diagnostic apparatus for medical purposes; Analysers for medical use; Apparatus for medical purposes, for analysis of the intestinal microbiota; Blood testing apparatus; Hypogastric belts; Dialyzers; Drainage tubes for medical use; Gastroscopes; Abdominal pads; Injectors for medical purposes; Enema apparatus for medical purposes; Artificial limbs, eyes and teeth; Orthopedic articles; Suture materials.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary preparations; Dietary supplements for humans and animals; Dietary supplements for humans and animals, namely nutrition supplements; Dietary supplements for humans and animals, namely dietetic food and substances adapted for medical or veterinary use; Chemical preparations for medical or pharmaceutical purposes; Chemical preparations adapted for medical or pharmaceutical use, namely microbiotherapy preparations for repairing the intestinal microbiome; Bacteriological preparations for medical and veterinary use; Bacterial preparations for medical and veterinary use; Biological preparations for medical or veterinary purposes; Mediums (Bacteriological culture -); Chemico-pharmaceutical preparations; Microbiotherapy preparations adapted for medical use for repairing the intestinal microbiome. Education; Providing of training; Providing of training, namely arranging and Conducting of colloquiums, Lectures, Congresses, Seminars; Education, namely organisation of exhibitions for educational purposes; Providing of training, namely arranging and Conducting workshops (training); Providing of training in the field of microbiotherapy. Engineering evaluations and appraisals in the fields of science and technology; Scientific and technical research; Research and development for others; Technical project studies; Chemical analysis; Chemist services; Clinical trials; Surveying; Laboratory (Scientific -) services; Research in biology, bacteriology, chemistry, physics; Scientific research in the field of microbiotherapy.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical and veterinary preparations; Dietary supplements for animals; Food supplements for animals, namely nutritional supplements; Food supplements for animals, namely dietetic food and substances for veterinary use; Chemical preparations for medical or pharmaceutical purposes; Chemical preparations adapted for medical or pharmaceutical use, namely microbiotherapy preparations for repairing the intestinal microbiome; Bacteriological preparations for medical and veterinary use; Bacterial preparations for medical and veterinary use; Biological preparations for medical or veterinary purposes; Mediums (Bacteriological culture -); Chemico-pharmaceutical preparations; Microbiotherapy preparations adapted for medical use for repairing the intestinal microbiome. Engineering evaluations and appraisals in the fields of science and technology; Scientific and technical research; Research and development for others; Project studies (Technical -); Chemical analysis; Chemist services; Clinical trials; Surveying; Laboratory (Scientific -) services; Research in biology, bacteriology, chemistry, physics; Scientific research in the field of microbiotherapy.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Education; Providing of training; Providing of training, namely arranging and Conducting of colloquiums, Lectures, Congresses, Seminars; Education, namely organisation of exhibitions for educational purposes; Providing of training, namely arranging and Conducting workshops (training); Providing of training in the field of microbiotherapy. Engineering evaluations and appraisals in the fields of science and technology; Scientific and technical research; Research and development for others; Project studies (Technical -); Chemical analysis; Chemist services; Clinical trials; Surveying; Laboratory (Scientific -) services; Research in biology, bacteriology, chemistry, physics; Scientific research in the field of microbiotherapy.
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France)
Inventeur(s)
Affagard, Herve
Schwintner, Carole
Juste, Catherine
Dore, Joel
Lepage, Patricia
Maillet, Christel
Rabot, Sylvie
Fonseca, Fernanda
Blottiere, Herve
Abrégé
The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between -15°C and -100°C. Steps b) to e) are carried out in anaerobiosis.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
60.
METHOD FOR LYOPHILISATION OF A SAMPLE OF FECAL MICROBIOTA
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France)
Inventeur(s)
Affagard, Herve
Schwintner, Carole
Juste, Catherine
Dore, Joel
Chapron, Audrey
Fonseca, Fernanda
David, Olivier
Abrégé
Method for lyophilisation of a sample of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than -50°C, preferably of between -70°C and -100°C, followed by the lyophilisation thereof.
The present invention relates to a pharmaceutical oral formulation for use in the administration of at least two bacteria derived from fecal microbiota to mammals for the treatment and/or prevention of dysbiosis and associated pathologies. The pharmaceutical oral formulation is encapsulated mixture of at least two bacteria derived from fecal microbiota wherein the capsules are coated in a pH responsive polymer composition comprising: a.50-70% poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1 by weight of dry polymer, b.10-30% poly(methacrylic acid-co-ethyl acrylate) 1:1 by weight of dry polymer, c.at least one fatty acid mono-, di-or tri-glyceride ester, or mixtures thereof, d.at least one plasticizer, e.at least one non-ionic emulsifier. The pharmaceutical oral formulation is especially designed to be delivered principally in the ileum and colon and to maintain the sample bacterial viability and diversity.
A61P 1/04 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des ulcères, des gastrites ou des œsophagites par reflux, p. ex. antiacides, antisécrétoires, protecteurs de la muqueuse
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
The invention relates to a container for the lyophilisation of a liquid or semi-liquid product. The container comprises an upper portion (2) provided with a membrane which is permeable to water vapour and a lower portion (3) comprising a reservoir designed to receive the product on a bottom. The container comprises internal partitions (21) in the reservoir (19) which form a plurality of product-receiving volumes (22-27), the internal partitions (21) being configured such that introducing product into one of the predefined receiving volumes (22) causes said receiving volumes (22-27) to be successively filled in a predetermined order.
F26B 5/06 - Procédés de séchage d'un matériau solide ou d'objets n'impliquant pas l'utilisation de chaleur par évaporation ou sublimation de l'humidité sous une pression réduite, p. ex. sous vide le procédé impliquant la congélation
63.
FMT PERFORMANCE PREDICTION TEST TO GUIDE AND OPTIMIZE THERAPEUTIC MANAGEMENT OF GVHD PATIENTS
The present disclosure relates to a method for assessing whether a GVHD subject in need of a complementation with live microorganisms can benefit from said complementation, by analysing the subject's microbiota and/or host parameters. Treatments for improving the status of patients identified as poor microbiotherapy responders are also provided, as well as materials and kits for performing the method according to the invention.
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France)
Inventeur(s)
Affagard, Herve
Schwintner, Carole
Verdier, Cecile
Denis, Sylvain
Brugere, Jean-Francois
Alric, Monique
Abrégé
The present invention concerns a method of expanding a complex community of microorganisms, an expanded complex community of microorganisms obtained by said method, a pharmaceutical formulation comprising said expanded complex community of microorganisms and the use of said expanded complex community of microorganisms and said pharmaceutical formulation.
An evolutionary algorithm is used to determine parameters of a production process of a complex microorganism community, CMC, product given a target profile for the CMC product. CMC mixing operation and co-cultivation operation of a CMC product are modelled, using learnt matrix-based models. The evolutionary algorithm iteratively modify candidates representing the parameters, including a set of complex microorganism community samples in the initial sample collection and mixing ratios for one or more mixing operations in the production process. The determined set of samples and associated mixing ratios are then used to control actual picking and processing of complex microorganism community samples according to the mix production process, to obtain a CMC product as close as possible, in terms of profiling features, to the target profile.
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
66.
MICROORGANISM SAMPLING METHOD, MICROORGANISM SAMPLING DEVICE AND SAMPLING KIT COMPRISING SUCH A SAMPLING DEVICE
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT (France)
Inventeur(s)
Schwintner, Carole
Affagard, Herve
Dore, Joel
Abrégé
Method for sampling micro-organisms in biological material with a sampling device comprising a container and a lid, with an outlet organ designed to, in an open state, remove part of the gases contained in the interior space of the container body, the outlet organ presenting opposite interior and exterior faces, the outlet organ being in the closed state at rest and moving to the open state when a pressure difference is applied between the interior and exterior faces, the sampling method comprising the following steps: - collecting biological material in the container body and mounting the lid on the neck of the container, and - placing an interior space in the container body in anaerobiosis by automatically placing the outlet organ in the open state while compressing the container body, then by automatically placing the outlet organ in a closed state by stopping compression of the container body.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61J 1/00 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques
67.
STOOL COLLECTION METHOD AND SAMPLE PREPARATION METHOD FOR TRANSPLANTING FECAL MICROBIOTA
The present invention relates to a method for preparing a homogeneous mixture of fecal microbiota from at least two preselected donors. The homogeneous mixture of fecal microbiota thus obtained has a bacterial diversity and an increased viability. The homogeneous mixture of fecal microbiota may be used for treating intestinal dysbiosis and for treating pathologies associated with such dysbiosis.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
68.
FECAL MICROBIOTA COMPOSITION, FOR USE IN REDUCING TREATMENT-INDUCED INFLAMMATION
The invention relates to the use of fecal microbiota transplant for preventing and/or reducing systemic and gut treatment-induced inflammation in an individual in need thereof.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
