A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 9/19 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres lyophilisées
29 - Viande, produits laitiers et aliments préparés ou conservés
Produits et services
Meat, fish, poultry and game; meat extracts; preserved,
frozen, dried and cooked fruit and vegetables; jellies,
jams, compotes; eggs, milk and dairy products; edible oils
and fats.
Mycobacterium tuberculosis-complex (MTB-C) strain. These particular fragments may be from a virulent MTB-C strain and/or in the form of a liposome composition. The agent may include further components, such as a liposome-forming agent and/or particular proteins from the MTB-C strain.
A particular allergic response that may be treated by the agent of the invention is allergic asthma. A pharmaceutical composition comprising the agent is also provided.
Administration of the agent described herein significantly attenuates airway hyperresponsiveness, eosinophilia and lymphocytosis in the airways of sensitized animals. The effectiveness of the agent exceeds on all the evaluated parameters the commercial vaccine BCG Danish 1331 Strain.
A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/04 - Mycobacterium, p. ex. Mycobacterium tuberculosis
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
49.
Liposome formulation suitable for treating or preventing tuberculosis
Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the liposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/06 - Phénols le noyau aromatique étant substitué par des groupes nitro
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
The invention relates to an agent for the treatment or prevention of an allergic condition, such as asthma, in a mammal. The agent comprises fragments of a Mycobacterium tuberculosis-complex (MTB-C) strain. These particular fragments may be from a virulent MTB-C strain and/or in the form of a liposome composition. The agent may include further components, such as a liposome-forming agent and/or particular proteins from the MTB-C strain. A particular allergic response that may be treated by the agent of the invention is allergic asthma. A pharmaceutical composition comprising the agent is also provided. Administration of the agent described herein significantly attenuates airway hyperresponsiveness, eosinophilia and lymphocytosis in the airways of sensitized animals. The effectiveness of the agent exceeds on all the evaluated parameters the commercial vaccine BCG Danish 1331 Strain.
The invention relates to an agent for the treatment or prevention of an allergic condition, such as asthma, in a mammal. The agent comprises fragments of a Mycobacterium tuberculosis-complex (MTB-C) strain. These particular fragments may be from a virulent MTB-C strain and/or in the form of a liposome composition. The agent may include further components, such as a liposome-forming agent and/or particular proteins from the MTB-C strain. A particular allergic response that may be treated by the agent of the invention is allergic asthma. A pharmaceutical composition comprising the agent is also provided. Administration of the agent described herein significantly attenuates airway hyperresponsiveness, eosinophilia and lymphocytosis in the airways of sensitized animals. The effectiveness of the agent exceeds on all the evaluated parameters the commercial vaccine BCG Danish 1331 Strain.
The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the Iiposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/06 - Phénols le noyau aromatique étant substitué par des groupes nitro
A61K 39/04 - Mycobacterium, p. ex. Mycobacterium tuberculosis
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose
53.
LIPOSOME FORMULATION SUITABLE FOR TREATING OR PREVENTING TUBERCULOSIS
The invention provides liposome formulations comprising fragments from a Mycobacterium tuberculosis-complex strain, it also provides a Mycobacterium tuberculosis-complex strain, fragments of which may be incorporated into selected embodiments of the liposome formulation. The invention further provides suspensions and pharmaceutical compositions comprising the liposome formulations. Furthermore, it discloses the use of the Iiposome formulations for use in a method of treatment of the human or animal body by therapy, in particular for use in a method of treating or preventing tuberculosis, such as in preventing latent tuberculosis or in tuberculosis prophylaxis, optionally in combination therapy. The formulation of this invention contains sucrose and/or has a lower average particle size than conventional liposome-based agents of tuberculosis therapy, resulting in higher bioavailability and efficiency.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 39/04 - Mycobacterium, p. ex. Mycobacterium tuberculosis
A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose
A61K 31/06 - Phénols le noyau aromatique étant substitué par des groupes nitro
54.
Immunotherapeutic agent suitable for the primary prophylaxis of tuberculosis
The invention relates to the use of an immunotherapeutic agent comprising cell wall fragments of a virulent strain of Mycobacterium tuberculosis for preparing a medicament suitable for the primary prophylaxis of tuberculosis. The immunotherapeutic agent can induce a protective response that is more effective than the conventional BCG vaccination and reduces the number of viable bacilli in the lungs and in the spleen of individuals recently infected with M. tuberculosis.
Mycobacterium tuberculosis-complex (MTB-C) for the preparation of a drug for the prophylactic treatment of tuberculosis, in which said agent can be obtained using a method comprising the following steps: cultivate the virulent MTB-C strain over a period equal to or greater than three weeks; and, subsequently, homogenate the cell culture in the presence of a nonionic surfactant.
The invention relates to the use of an immunotherapeutic agent containing cell wall fragments of a virulent strain of Mycobacteríum tuberculosis-complex (MTB-C) for the preparation of a drug for the prophylactic treatment of tuberculosis, in which said agent can be obtained using a method comprising the following steps: cultivation of the virulent MTB-C strain over a period equal to or greater than three weeks; and, subsequently, homogenisation of the cell culture in the presence of a nonionic surfactant.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes, dietetic substances adapted for medical use, food for babies; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.
29 - Viande, produits laitiers et aliments préparés ou conservés
35 - Publicité; Affaires commerciales
39 - Services de transport, emballage et entreposage; organisation de voyages
Produits et services
Milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Advertising services; commercial retailing, import, export, agency, sales promotion (for others) in the marketing of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Storage, warehousing, packaging, supply, transport and distribution of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives.
29 - Viande, produits laitiers et aliments préparés ou conservés
35 - Publicité; Affaires commerciales
39 - Services de transport, emballage et entreposage; organisation de voyages
Produits et services
Printed matter, pamphlets, catalogues, cards, wrapping of paper, cardboard or plastic materials for packaging purposes (not included in other classes) for use in the marketing of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Advertising; import, export, agency, sales promotion (for others) in the marketing of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Storage, warehousing, packaging, supply, transport and distribution of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives.
29 - Viande, produits laitiers et aliments préparés ou conservés
35 - Publicité; Affaires commerciales
39 - Services de transport, emballage et entreposage; organisation de voyages
Produits et services
Printed matter, pamphlets, catalogues, cards, wrapping of paper, cardboard or plastic materials for packaging purposes (not included in other classes) for use in the marketing of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Advertising; import, export, agency, sales promotion (for others) in the marketing of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Storage, warehousing, packaging, supply, transport and distribution of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives.
29 - Viande, produits laitiers et aliments préparés ou conservés
35 - Publicité; Affaires commerciales
39 - Services de transport, emballage et entreposage; organisation de voyages
Produits et services
Printed matter, pamphlets, catalogues, cards, wrapping of paper, cardboard or plastic materials for packaging purposes (not included in other classes) for use in the marketing of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Advertising; import, export, agency, sales promotion (for others) in the marketing of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives. Storage, warehousing, packaging, supply, transport and distribution of milk products in general, including cheeses in all their speciality forms, butter, margarine, milk, yoghurt, cream and other milk derivatives.
