Abrégé

A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.

Classes IPC  ?

• A61L 31/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 31/10 - Matériaux macromoléculaires
• A61L 31/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques

Abrégé

Provided is a method of predicting a response of a subject afflicted with an autism spectrum disorder (ASD) to bumetanide based on baseline expression levels of a set of cytokines in the subject, baseline behavioral performance of the subject and clinical information of the subject and the use thereof. Also provided are a prediction device and a computer readable medium for performing the prediction method.

Classes IPC  ?

• C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
• G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres

Abrégé

An absorbable vascular stent and a preparation method therefor, where an atomic layer deposition technique is utilized to deposit a structurally uniform TiO2 thin film on a PPDO monofilament, and a titanized PPDO monofilament is obtained; subsequently, the titanized PPDO monofilament is used as a core yarn and a PCL multifilament as a shell yarn, and a core-spun yarn where the shell yarn completely covers the core yarn is formed; then, the core-spun yarn and the titanized PPDO monofilament are respectively interwoven in opposite directions and a surface of a mold is covered, and a braided vascular stent semifinished tube is formed; last, same is placed in high temperatures, causing adhesion of core-spun yarn that is in mutual contact at interweaving points, and the absorbable vascular stent is obtained. When degrading the stent in a 37 °C deionized water bath environment, 70% of yarn breakage occurred at days 170-195, and by means of adjusting the TiO2 deposition thickness on a monofilament surface, a lumen that remains unobstructed and maintains a stable size approximately 6 months after vascular stent implantation is achieved.

Classes IPC  ?

• A61F 2/86 - Stents ayant une forme caractérisée par des éléments filiformesStents ayant une forme caractérisée par une structure de type filet ou de type à mailles

Abrégé

The present invention provides a method for preparing a drug-loaded micelle for an absorbable vascular stent coating for an infant narrow blood vessel, comprising the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifier, then adding chitosan-polydioxanone amphiphilic block copolymer andfully mixing to prepare a drug-copolymer solution; S2: adding drop by drop the drug-copolymer solution obtained in S1 to a pre-prepared emulsifier aqueous solution, and continuously stirring until a stable drug-carrying micelle solution is formed; S3: subjecting the micelle solution of S2 to reduced pressure evaporation, so as to remove the emulsifier and then stirring, and sequentially performing centrifugal separation, filtration and dialysis on the product to obtain a drug-carrying micelle. Also specifically disclosed is that the drug-loaded micelle is sprayed on the surface of an absorbable vascular stent to prepare a drug-loaded coating, thereby significantly improving the biocompatibility thereof, and by means of the pH value of the pH-responsive drug-loaded micelle changing with the depredation of the scaffold framework and the blank top layer, achieving the purpose of drug sustained release.

Classes IPC  ?

• A61L 31/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone

Abrégé

A method and apparatus for obtaining a cell classification model, and a computer readable storage medium. The method comprises: obtaining a trained initial cell classification model; obtaining, according to test data and the initial cell classification model, M feature maps of a target to be classified, M being a positive integer greater than or equal to 1, and the test data comprising one or more targets to be classified; obtaining weights of the M feature maps; and inputting the M feature maps having the weights into the initial cell classification model, and retraining the initial cell classification model to optimize the initial cell classification model, so as to obtain a final cell classification model.

Classes IPC  ?

• G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
• G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
• G06N 3/08 - Méthodes d'apprentissage

Abrégé

The invention described herein provides neutralizing antibodies against SARS-CoV-2 antigens (such as the S1 subunit of the S antigen), for use in treating human patients with COVID-19.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• C12N 15/13 - Immunoglobulines
• A61K 39/42 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire viraux
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C12N 15/63 - Introduction de matériel génétique étranger utilisant des vecteursVecteurs Utilisation d'hôtes pour ceux-ciRégulation de l'expression

Abrégé

Provided is the use of a class of tanshinone compounds for treating hemangioma; in particular, provided is the use of a class of compounds as shown in formula I below or a pharmaceutically acceptable salt thereof. The tanshinone compounds have a hemangioma cell inhibitory activity and can be used for preparing a pharmaceutical composition for treating hemangioma.

Classes IPC  ?

• C07J 73/00 - Stéroïdes ayant le squelette du cyclopenta[a]hydrophénanthrène modifié par substitution d'un ou deux atomes de carbone par des hétéro-atomes
• C07C 50/16 - Quinones la structure quinoïde faisant partie d'un système cyclique condensé comportant trois cycles
• A61K 31/343 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à cinq chaînons avec un oxygène comme seul hétéro-atome d'un cycle, p. ex. isosorbide condensés avec un carbocycle, p. ex. coumarane, bufaralol, béfunolol, clobenfurol, amiodarone
• A61K 31/122 - Cétones ayant l'atome d'oxygène lié directement à un cycle, p. ex. quinones, vitamine K1, anthraline
• A61P 35/00 - Agents anticancéreux

Abrégé

A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.

Classes IPC  ?

• A61B 17/58 - Instruments ou procédés chirurgicaux pour le traitement des os ou des articulationsDispositifs spécialement adaptés à cet effet pour ostéosynthèse, p. ex. plaques, vis ou matériels de fixation
• A61B 17/80 - Plaques corticales

Abrégé

A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.

Classes IPC  ?

• A61B 17/80 - Plaques corticales
• A61B 17/56 - Instruments ou procédés chirurgicaux pour le traitement des os ou des articulationsDispositifs spécialement adaptés à cet effet
• A61F 5/01 - Dispositifs orthopédiques, p. ex. dispositifs pour immobiliser ou pour exercer des pressions de façon durable pour le traitement des os fracturés ou déformés, tels que éclisses, plâtres orthopédiques ou attelles