01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry, science and photography, as well
as in agriculture, horticulture and forestry; unprocessed
artificial resins, unprocessed plastics; fertilizers; fire
extinguishing compositions; tempering and soldering
preparations; chemical preservatives for food; tanning
substances; adhesives used in industry; ingredients for use
in the medical and veterinary industry. Pharmaceutical preparations and veterinary preparations,
other than oral contraceptives and pharmaceutical
preparations for treatment of celiac disease; sanitary
preparations for medical purposes (other than for use as
finished preparations for diagnosis); dietetic preparations
for medical use, food for babies; plasters and medical
dressings; material for stopping teeth and for dental
impression; disinfectants; preparations for destroying
vermin; fungicides and herbicides; vitamin preparations,
nutritional supplements and food supplements. Surgical, medical, dental and veterinary apparatus and
instruments, other than diagnostic apparatus and tests for
the diagnosis of celiac disease; artificial limbs, eyes and
teeth; orthopaedic articles; suture materials. Scientific and technological services and research and
design relating thereto; industrial analysis and research
services; design and development of computer hardware and
software.
The present disclosure is generally directed to storage stable formulations of cisatarcurium. A ready-to-administer aqueous formulation is provided comprising cisatracurium or a pharmaceutically acceptable salt thereof and an osmolality adjusting agent that is sodium chloride.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; fertilizers; fire extinguishing compositions; tempering and soldering preparations; chemical preservatives for food; tanning substances; adhesives used in industry; ingredients for use in the medical and veterinary industry. Pharmaceutical preparations and veterinary preparations, other than oral contraceptives and pharmaceutical preparations for treatment of celiac disease; sanitary preparations for medical purposes (other than for use as finished preparations for diagnosis); dietetic preparations for medical use, food for babies; plasters and medical dressings; material for stopping teeth and for dental impression; disinfectants; preparations for destroying vermin; fungicides and herbicides; vitamin preparations, nutritional supplements and food supplements. Surgical, medical, dental and veterinary apparatus and instruments, other than diagnostic apparatus and tests for the diagnosis of celiac disease; artificial limbs, eyes and teeth; orthopaedic articles; suture materials. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software.
The present disclosure relates to a ready-to-use formulation of vasopressin, the process for making such formulations and use of such formulations for treatment of a patient in need thereof.
The present disclosure relates to a stable aqueous composition of dalbavancin, the process for making such compositions and use of such compositions for treatment of a patient in need thereof.
The present disclosure relates to a stable aqueous composition of dalbavancin, the process for making such compositions and use of such compositions for treatment of a patient in need thereof.
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
An optimized method for synthesizing dalbavancin is provided in which an organic antisolvent such as tert-butyl methyl ether (TBME) or dimethoxyethane (DME) is used to precipitate the product of the esterification of A-40926.
Described herein is a product including a ready-to-administer injectable formulation, the formulation including phenylephrine or a pharmaceutically acceptable salt thereof, a tonicity agent and a pH adjusting agent, wherein the pH adjusting agent is selected from hydrochloric acid, tartaric acid, and mixtures thereof; and wherein the formulation is contained in a flexible PVC-free plastic container.
Described herein is a product including a ready-to-administer injectable formulation, the formulation including phenylephrine or a pharmaceutically acceptable salt thereof, a tonicity agent and a pH adjusting agent, wherein the pH adjusting agent is tartaric acid; and wherein the formulation of this oxygen sensitive substance is stable for prolonged period of times even when manufactured without protection from oxygen and when packed and stored in a flexible plastic container without modification of atmosphere by oxygen removal from the bag or the overwrap.
The present disclosure relates to a ready-to-administer formulation of oxytocin, its pharmaceutically acceptable salts, or derivatives thereof, as well as products comprising the formulation. Specifically, the disclosure is directed to storage stable ready-to-administer formulations of oxytocin, method of producing such formulations and uses thereof.
Described herein are ready to use oral liquid unit dosage forms including vancomycin or a salt thereof, N-acetyl-D-alanine, and/or an amino acid and a polyethylene glycol, optionally a pH adjusting agent, optionally a preservative, and water, wherein the molar ratio of vancomycin to N-acetyl-D-alanine is 1 :2 to 1 : 44, wherein the molar ratio of vancomycin to amino acid is 1 :0.5 to 1 :26, wherein the oral liquid unit dosage form has a pH of 3.8 to 4.4 and wherein the oral liquid unit dosage form includes no added sweetener and no added flavoring agent. Also included are method of improving patient compliance and methods of taste masking vancomycin oral liquid formulations.
An optimized method for synthesizing dalbavancin is provided in which an organic antisolvent such as tert-butyl methyl ether (TBME) or dimethoxyethane (DME) is used to precipitate the product of the esterification of A-40926.
The present invention relates to pharmaceutical compositions comprising at least one beta-lactam compound and at least one N-acetyl amino acid amide. Such compositions provide good stability over time. Also provided are a method for treating bacterial infections in a subject by administering any of the compositions described herein, as well as a method for stabilizing beta-lactam compound in a pharmaceutical composition by mixing beta-lactam compound and at least one N-acetyl amino acid amide.
A61K 31/43 - Composés contenant des systèmes cycliques thia-4 aza-1 bicyclo [3.2.0] heptane, c.-à-d. composés contenant un système cyclique de formule , p. ex. pénicillines, pénèmes
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
The present invention relates to pharmaceutical compositions comprising piperacillin and/or tazobactam and at least one N-acetyl amino acid amide. Such compositions provide good stability over time. Also provided are a method for treating bacterial infections in a subject by administering any of the compositions described herein, as well as a method for stabilizing piperacillin and/or tazobactam in a pharmaceutical composition by mixing piperacillin and/or tazobactam and at least one N-acetyl amino acid amide.
A61K 31/431 - Composés contenant des systèmes cycliques thia-4 aza-1 bicyclo [3.2.0] heptane, c.-à-d. composés contenant un système cyclique de formule , p. ex. pénicillines, pénèmes contenant d'autres systèmes hétérocycliques, p. ex. ticarcilline, azlocilline, oxacilline
A61K 31/496 - Pipérazines non condensées contenant d'autres hétérocycles, p. ex. rifampine, thiothixène ou sparfloxacine
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A liquid pharmaceutical composition comprising ceftriaxone or a pharmaceutical acceptable salt or derivative thereof and at least one magnesium salt, magnesium oxide, and/or magnesium hydroxide is provided. Also provided are a method for treating bacterial infections in a subject by administering any of the compositions described herein, as well as a method for stabilizing ceftriaxone in a liquid pharmaceutical composition by mixing ceftriaxone and at least one magnesium salt, magnesium oxide, and/or magnesium hydroxide.
A61K 31/546 - Composés contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. composés contenant un système cyclique de formule , p. ex. céphalosporines, céfaclor, céphalexine contenant d'autres hétérocycles, p. ex. céphalotine
C07D 501/00 - Composés hétérocycliques contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. des composés contenant un système cyclique de formule , p. ex. céphalosporinesCes systèmes cycliques étant ultérieurement condensés, p. ex. condensés en positions 2, 3 avec des hétérocycles contenant de l'oxygène, de l'azote ou du soufre
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present disclosure relates to a solid formulation of daptomycin comprising at least one branched aliphatic amino acid. Solid daptomycin formulation of the present disclosure shows improved reconstituted time. The disclosure further relates to a method of preparation of the solid daptomycin formulation according to this disclosure.
The present disclosure is related to providing a stable daptomycin aqueous pharmaceutical formulations as a contrast to the inconvenient and potentially problematic methods of lyophilized drug preparation and administration, wherein the aqueous formulations of daptomycin offer the advantage of ease of handling with a high degree of patient acceptability and compliance.
The present invention relates to compositions comprising daptomycin and at least one amino acid, methods of providing such compositions and the uses thereof.
Disclosed herein is a pulmonary administration device, comprising a spray nozzle unit and a cartridge containing an aqueous solution comprising from 70 to 400 mg A/m L of a sulfomethylated polymyxin, and use of sulfomethylated polymyxin in a device for pulmonary administration in a patient in need thereof.
The present invention relates to liquid pharmaceutical compositions comprising daptomycin, methods of providing such compositions and the use thereof. Provided herein are formulations comprising daptomycin, one or more polar protic solvents, and mixtures thereof. Formulations according to the present invention can further comprise polar aprotic solvent and/or source of calcium.
Disclosed herein are liquid formulations of glycopeptide antibiotics or pharmaceutically acceptable salts thereof, wherein glycopeptide antibiotic is selected from Vancomycin, Telavancin, Oritavancin, Teicoplanin and Dalbavancin. Said formulations are suitable as infusion solutions or as a concentrate for making infusion solutions.
Disclosed herein is an aqueous solution comprising from 80 mg A/mL to 400 mg A/mL of a sulfomethylated polymyxin and a cartridge containing the same. In addition it is disclosed an aqueous solution for use in therapy.
The present invention relates to new polymorphs consisting in crystallines solvates of Tiacumicin B, the solvates being propanol, isopropanol, acetic acid, isopropyl acetate, chlorobenzene and methyl-ethyl-ketone. The present invention also relates to a new amorphous form of Tiacumicin B.
The present invention is directed to stable formulations comprising therapeutically effective amount of anidulafungin and buffering agent selected from glutamic, picolinic and benzoic acid.
The present invention relates to polymyxin derivatives and their use as antimicrobial compounds, especially for use in the treatment of bacterial infections caused by gram-negative bacteria, including infections caused by multi drug resistant gram-negative bacteria.
Solutions comprising a glycopeptide antibiotic, for example Vancomycin, and an amino acid or amino acid derivative such as N-acetyl-Glycine or N-acetyl-D-Alanine are provided. These solutions are stable or stabilized for long-term periods at conditions of normal use and storage, and can be formulated as pharmaceutical solutions for use in subjects. Methods of manufacturing and using these solutions are also provided, as are methods of stabilizing a glycopeptide antibiotic, for example Vancomycin, using amino acids or amino acid derivatives such as N-acetyl-Glycine or N-acetyl-D-Alanine.
A61K 38/14 - Peptides contenant des radicaux saccharideLeurs dérivés
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
Disclosed herein is a pulmonary administration device, comprising a spray nozzle unit and a cartridge containing an aqueous solution comprising from 70 to 400 mg A/m L of a sulfomethylated polymyxin, and use of sulfomethylated polymyxin in a device for pulmonary administration in a patient in need thereof.
Disclosed herein is an aqueous solution comprising from 80 mg A/mL to 400 mg A/mL of a sulfomethylated polymyxin and a cartridge containing the same. In addition it is disclosed an aqueous solution for use in therapy.
supplying energy in the form of a combination of high-voltage electric pulses and ultrasound pulses to the reaction mixture to enhance dissolution of the minerals.
C22B 4/00 - Traitement électrothermique des minerais ou des produits métallurgiques pour obtenir des métaux ou des alliages
C22B 3/06 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés par lixiviation dans des solutions inorganiques acides
C22B 3/18 - Extraction de composés métalliques par voie humide à partir de minerais ou de concentrés à l'aide de micro-organismes ou d'enzymes, p. ex. de bactéries ou d'algues
34.
NEW POLYMORPHS AND NEW SOLID STATES OF TIACUMICIN B
The present invention relates to new polymorphs consiting in crystallines solvates of Tiacumicin B, the solvates being propanol, isopropanol, acetic acid, isopropyl acetate, chlorobenzene and methyl-ethyl-ketone. The present invention also relates to a new amorphous form of Tiacumicin B.
The present invention relates to the preparation of Tiacumicin B from a Dactylosporangium or Actinoplanes strain capable of producing Tiacumicin B utilizing spray drying or freeze drying and further extraction of the dried powder.
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
A system for intravenous therapy is disclosed. The system includes a first container defining an interior sized to hold a drug composition. The first container includes a first sterile port defining a key structure. The system further includes a second container defining an interior sized to hold a pharmaceutically acceptable composition. The second container includes a second sterile port having a lock structure. The key structure of the first container is sized to be mated with the lock structure of the second container to connect the first container to the second container when the drug composition in the first container is compatible with the pharmaceutically acceptable composition in the second container.
The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and succinate or lactate as a buffering agent.
A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
The present invention relates to a method for the purification of Micafungin. Specifically, a method is provided in which a micafungin starting material containing a first micafungin salt is adsorbed to a solid support, the adsorbed micafungin is washed with an aqueous solution comprising a dissolved second salt, the second micafungin salt is eluted using a water miscible organic solvent.
C07K 7/56 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle cyclisés autrement que par l'acide diamino-2,4 butanoïque
A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
The present invention regards a HPLC method useful for analyzing colistimethate sodium (CMS) or for the separation of CMS components. It consists in a HPLC method using a hydrophobic stationary phase and a mobile phase comprising an aqueous buffer and an organic solvent whose concentration in the mobile phase is increased during the elution. The aqueous buffer is preferably a phosphate buffer and the organic solvent preferably acetonitrile.
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
B01D 15/32 - Chromatographie en phase liée, p. ex. avec une phase normale liée, une phase inverse ou une interaction hydrophobe
The present invention relates to a method for stabilizing Tigecycline using nitric acid or sulphuric acid. The present invention furthermore relates to Tigecycline compositions comprising nitric acid or sulphuric acid as the only pH adjusting agent.
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
Disclosed herein is a composition comprising at least one polymyxin or a salt thereof represented by formula (I) wherein R1 is an aliphatic linear or branched C6-C10 acyl group, or (I') R5 is -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)CH2CH3, or -CH2C6H5; R6 is -CH(CH3)2, -CH2CH(CH3)2, or -CH(CH3)CH2CH3; each of R2, R3, R4, R7and R8 is either -(CH2)XCH2NH2 or -(CH2)xCH2N(CH2SO3M)2; wherein x is 0 or 1; wherein M is a monovalent cation; and wherein at least three of R2, R3, R4, R7and R8 are -(CH2)xCH2N(CH2SO3M)2.
A61K 47/48 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p.ex. supports, additifs inertes l'ingrédient non actif étant chimiquement lié à l'ingrédient actif, p.ex. conjugués polymère-médicament
The present invention regards a novel administration form and a novel administration regime useful in the treatment and prevention of a bacterial lung infection in patient in need thereof, in particular by providing a composition useful for aerosolization of a highly concentrated solution of aminoglycosides such as Tobramycin.
A61M 11/02 - Pulvérisateurs ou vaporisateurs spécialement destinés à des usages médicaux agissant par pression d'air sur les liquides à pulvériser ou vaporiser
A61K 31/70 - Hydrates de carboneSucresLeurs dérivés
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
The present invention relates to novel intermediates of Formula (I), wherein R3 is H, X is O or N, R1 or R2 is either absent or independently H, alkyl or acyl, and provided that when X is O, then R1 is absent and the process for the preparation of ixabepilone utilizing said intermediates.
C07D 417/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
C07K 7/56 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle cyclisés autrement que par l'acide diamino-2,4 butanoïque
C07K 7/56 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle cyclisés autrement que par l'acide diamino-2,4 butanoïque
54.
Method for purification of colistin and purified colistin components
The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
G01N 1/18 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide avec mesures prises pour diviser des échantillons en plusieurs parties
A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
A61K 38/04 - Peptides ayant jusqu'à 20 amino-acides dans une séquence entièrement déterminéeLeurs dérivés
The present invention concerns 2-amino-3-methyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it.
C07C 229/00 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné
C07C 229/08 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe amino et un seul groupe carboxyle liés au squelette carboné l'atome d'azote du groupe amino étant lié de plus à des atomes d'hydrogène
C07C 229/30 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et non saturé
The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and succinate or lactate as a buffering agent.
The present invention regards a novel administration form and a novel administration regime useful in the treatment and prevention of a bacterial lung infection in patient in need thereof, in particular by providing a composition useful for aerosolization of a highly concentrated solution of aminoglycosides such as Tobramycin.
A61K 31/7036 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine ayant au moins un groupe amino lié directement au carbocycle, p. ex. streptomycine, gentamycine, amikacine, validamycine, fortimicines
The present invention regards a novel administration form and a novel administration regime useful in the treatment and prevention of a bacterial lung infection in patient in need thereof, in particular by providing a composition useful for aerosolization of a highly concentrated solution of aminoglycosides such as Tobramycin.
A01N 43/04 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome
A61K 31/70 - Hydrates de carboneSucresLeurs dérivés
60.
2-AMINO-3-METHYL-HEX-5-ENOIC ACID AND ITS USE IN THE PRODUCTION OF PEPTIDES SUCH AS BACITRACINS
The present invention concerns 2-amino-3-methyl-hex-5-enoic acid, its use for the production of peptides such as bacitracins and a method for producing it.
C07C 229/30 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et non saturé
C07C 227/16 - Préparation de composés contenant des groupes amino et carboxyle liés au même squelette carboné à partir de composés contenant déjà des groupes amino et carboxyle ou leurs dérivés par des réactions n'impliquant pas les groupes amino ou carboxyle
The present invention concerns a method of purifying colistin using reverse phase chromatography, wherein loading a column with colistin base in acetic acid and high ethanol concentration and eluting with low ethanol concentration is performed.
The present invention concerns a method for separation of the antifungal cyclic hexapeptides Pneumocandin B0 from Pneumocandin C0 using a hydrophilic stationary phase and a hydrophobic mobile phase.
B01D 15/08 - Adsorption sélective, p. ex. chromatographie
C07K 7/56 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle cyclisés autrement que par l'acide diamino-2,4 butanoïque
The present invention concerns a method of detecting the antifungal cyclic hexapeptides Pneumocandin B0 and/or Pneumocandin C0 specific fragment is/are detected using MS in negative mode.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C07K 7/56 - Peptides cycliques contenant au moins une liaison peptidique anormale comportant au moins une liaison peptidique anormale dans le cycle cyclisés autrement que par l'acide diamino-2,4 butanoïque
The present invention relates to a process for purifying lipopeptides. More particular, the invention provides an improved method for purifying daptomycin.
C07K 1/36 - ExtractionSéparationPurification par une combinaison de plusieurs procédés de types différents
C12P 17/18 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle contenant plusieurs hétérocycles condensés entre eux ou condensés avec un système carbocyclique commun, p. ex. rifamycine
C12P 21/02 - Préparation de peptides ou de protéines comportant une séquence connue de plusieurs amino-acides, p. ex. glutathion
67.
Process for the purification of macrolide antibiotics
The present invention concerns a process for the purification of macrolide antibiotics. More specifically it concerns a process for the purification of macrolide antibiotics that result in a white powder. The powder remains white also after some time of storage. The process of the present invention is performed by dissolving the macrolide antibiotics, e.g. commercial vancomycin hydrochloride, in water and subjecting the solution to ultrafiltration with a membrane having nominal retention lower than 30,000 Da, preferably of 10,000 Da. The purified solution is preferably concentrated by reversed osmosis and then lyophilized at the optimized conditions of pressure and temperature to obtain a white powder.
The present invention relates to a process for purifying lipopeptides. More particular, the invention provides an improved method for purifying daptomycin.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Chemicals used in industry and science, namely antibiotic, anti-infective, anti-viral, anti-fungal and anti-inflammatory active pharmaceuticals ingredients for use in the pharmaceutical and veterinary industry; bulk chemicals and substances for use in the manufacture of pharmaceutical and veterinary preparations; pharmaceutical and veterinary preparations, namely anti-infective, anti-viral, antibiotic, anti-fungal and anti-inflammatory preparations in bulk and finished dosage form for medical and veterinary purposes; sanitary preparations for medical and veterinary purposes; disinfectants for sanitary and medical purposes; medical apparatus for facilitating the inhalation of pharmaceutical preparations (1) Medical, chemical and scientific research services in the field of anti-infectives, anti-virals, antibiotics, anti-fungals and anti-inflammatories; pharmaceutical, pharmaceutical ingredient and chemical development services; chemical and pharmaceutical research and development of processes for production of pharmaceuticals, pharmaceutical ingredients and chemicals for others; design and development of computer software for use in relation to medical services
70.
PROCESS FOR PREPARING CASPOFUNGIN AND INTERMEDIATES THEREOF
The present invention relates to novel intermediates of formula (VII), or an acid addition salt or a solvate thereof, wherein R1 is -(CO)NH2, -CH2NH2 or -CN; R2 = R3 = H or R2 and R3 together form a cyclic boronate or borate ester; X is a helping group selected from the group consisting of i) a five or six membered heterocyclic aromatic ring and derivatives thereof comprising at least one N-atom being a part of an imine-group, wherein said N-atom forms the point of connection to the cyclohexapeptide ring, and ii) tetrazolyl and derivatives thereof for which a nitrogen atom forms the point of connection to the cyclohexapeptide ring, and a process for the preparation of caspofungin utilizing said intermediates.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry, science and photography, as well
as in agriculture, horticulture and forestry; unprocessed
artificial resins, unprocessed plastics; manures; fire
extinguishing compositions; tempering and soldering
preparations; chemical substances for preserving foodstuffs;
tanning substances; adhesives used in industry. Pharmaceutical and veterinary preparations and sanitary
preparations for medical purposes (not for use as finished
diagnostic preparations); dietetic substances adapted for
medical use, food for babies; plasters, materials for
dressings; material for stopping teeth, dental wax;
disinfectants; preparations for destroying vermin;
fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and
instruments, artificial limbs, eyes and teeth; orthopedic
articles; suture materials. Scientific and technological services and research and
design relating thereto; industrial analysis and research
services; design and development of computer hardware and
software.
A novel and improved method for purification of glycopeptides, especially glycopeptide antibiotics. The method comprises contacting a solution of the glycopeptide to an ion exchange chromatography material. The product of this method has a surprisingly high purity.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry; unprocessed artificial resins, unprocessed plastics; manures; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry. Pharmaceutical and veterinary preparations, specifically excluding oral contraceptives and pharmaceutical preparations for the treatment of celiac disease and diagnostic tests for celiac disease; sanitary preparations for medical purposes (not for use as finished diagnostic preparations); dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, specifically excluding diagnostic apparatus and tests for diagnosing celiac disease; artificial limbs, eyes and teeth; orthopedic articles; suture materials. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry and science, namely, antibiotic, anti-infective, anti-viral, anti-fungal and anti-inflammatory active pharmaceutical ingredients for use in the pharmaceutical and veterinary industry; bulk chemicals for use in the manufacture of pharmaceutical and veterinary preparations Pharmaceutical and veterinary preparations, namely, anti-infective, anti-viral, antibiotic, anti-fungal and anti-inflammatory preparations in bulk and finished dosage form for medical and veterinary purposes, not for use as finished diagnostic preparations and specifically excluding finished pharmaceutical preparations in the form of tablets as well as cardiovascular finished pharmaceutical preparations; sanitary preparations for medical purposes, not for use as finished diagnostic preparations; [ dietetic substances adapted for medical use, namely, foods; ] disinfectants for sanitary and medical purposes; [ preparations for destroying vermin; ] fungicides; herbicides [ Medical apparatus for introducing pharmaceutical preparations into the human body, specifically excluding cardiovascular preparations ] Medical and scientific research services in the field of anti-infectives, anti-virals, antibiotics, anti-fungals and anti-inflammatories; pharmaceutical, pharmaceutical ingredient and chemical development services; chemical and pharmaceutical research services and pharmaceutical drug development services [ ; design and development of computer software for use in relation to medical services ]
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
16 - Papier, carton et produits en ces matières
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry and science; ingredients for use
in the pharmaceutical and veterinary industry. Pharmaceutical and veterinary preparations; sanitary
preparations for medical purposes; vitamin preparations,
nutritional supplements and food supplements; disinfectants;
preparations for destroying vermin; fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and
instruments. Paper, cardboard and goods made from these materials, not
included in other classes; printed matter; bookbinding
material; instructional and teaching material (except
apparatus). Scientific and technological services and research and
design relating thereto; industrial analysis and research
services; design and development of computer hardware and
software.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical used in industry, science and photography; unprocessed artificial resins, unprocessed plastics; fire extinguishing compositions; tempering and soldering preparations; chemical substances for preserving foodstuffs; tanning substances; adhesives used in industry. Pharmaceutical and veterinary preparations; sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin, fungicides, herbicides. Surgical, medical, dental and veterinary apparatus and instruments, artificial limbs, eyes and teeth; orthopedic articles; suture materials. Scientific and technological services and research and design relating thereto; industrial analysis and research services; design and development of computer hardware and software.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry and science, namely, antibiotic, anti-infective, anti-viral, anti-fungal and anti-inflammatory active pharmaceutical ingredients for use in the pharmaceutical and veterinary industry; bulk chemicals for use in the manufacture of pharmaceutical and veterinary preparations Pharmaceutical and veterinary preparations, namely, anti-infective, anti-viral, antibiotic, anti-fungal and anti-inflammatory preparations in bulk and finished dosage form for medical and veterinary purposes; sanitary preparations for medical purposes; [ vitamin preparations, nutritional supplements and food supplements; ] disinfectants for sanitary and medical purposes; [ preparations for destroying vermin; ] fungicides [ Medical apparatus for introducing pharmaceutical preparations into the human body ] Medical and scientific research services in the field of anti-infectives, anti-virals, antibiotics, anti-fungals and anti-inflammatories; pharmaceutical, pharmaceutical ingredient and chemical development services; chemical and pharmaceutical research services and pharmaceutical drug development services [ ; design and development of computer software for use in relation to medical services ]
79.
Glycopeptide composition with improved antibiotic activity
A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
A01N 43/04 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un ou plusieurs atomes d'oxygène ou de soufre comme uniques hétéro-atomes du cycle avec un hétéro-atome
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 31/70 - Hydrates de carboneSucresLeurs dérivés
80.
Glycopeptide composition with improved antibiotic activity
A glycopeptide composition with improved antibiotic activity is disclosed, along with a method of preparing such a composition and a pharmaceutical composition made therefrom.
A01N 37/18 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant le groupe —CO—N, p. ex. amides ou imides d'acide carboxyliqueLeurs thio-analogues
A61K 35/00 - Préparations médicinales contenant des substances ou leurs produits de réaction de constitution non déterminée
