Mass spectrometers are disclosed. The mass spectrometer includes a cleaning subsystem. The cleaning subsystem includes a first connection connectable to a source of an oxygen-containing gas. The cleaning subsystem includes a second connection connectable to a source of water. The cleaning subsystem further includes an ozone generator. The cleaning subsystem is constructed and arranged to provide hydroxyl radicals and ozone to one or more ion optics of the mass spectrometer. Methods of retrofitting a mass spectrometer with a cleaning subsystem are also disclosed. A non-transitory computer-readable medium for operating a mass spectrometer having a cleaning subsystem are also disclosed.
Methods and apparatus are provided for washing pipette tips, including the inside and outside of the pipette tip. Pipette wash devices comprise a main body comprising a wash chamber, a liquid channel a gas channel and a nozzle cavity, and a nozzle for providing a washing mist is positioned in the nozzle cavity and fluidically connected with the liquid channel and the gas channel. Methods of washing a pipette tip include inserting a pipette tip in a wash chamber; spraying a mist on an outside surface of the pipette tip, and blowing pressurized air or inert gas on the outside surface of the pipette, thereby washing and drying the pipette. Methods of washing a pipette tip also include passing one or more series of liquid slugs separated by gaseous gaps through the inside of the pipette tip.
B08B 9/032 - Nettoyage des surfaces intérieuresÉlimination des bouchons par l'action mécanique d'un fluide en mouvement, p. ex. par effet de chasse d'eau
A scroll pump or pumping system is configured to determine or predict whether a first scroll tip seal and/or a second scroll tip seal is a worn tip seal that should be replaced with a new tip seal. The determination or prediction is based on durations of run times during which the scroll pump operates in different, respective pressure ranges of pump inlet pressure, and durations of expected service lives of the scroll tip seals when operating in the respective pressure ranges.
F04C 18/02 - Pompes à piston rotatif spécialement adaptées pour les fluides compressibles du type à engrènement, c.-à-d. avec un mouvement de translation circulaire des organes coopérants, chaque organe possédant le même nombre de dents ou de parties équivalentes de prise
F04C 27/00 - Systèmes d'étanchéité dans les pompes à piston rotatif spécialement adaptées pour les fluides compressibles
F04C 28/06 - Commande, surveillance ou dispositions de sécurité pour les pompes ou les installations de pompage spécialement adaptées pour les fluides compressibles spécialement adaptées pour arrêter, pour démarrer, pour le ralenti ou pour un fonctionnement à charge nulle
4.
DETERMINING TIP SEAL MAINTENANCE REQUIREMENT IN SCROLL PUMP
A scroll pump or pumping system is configured to determine whether tip seals of the scroll pump require maintenance such as replacement. During operation of the scroll pump, pump inlet pressure is measured or calculated over a recent time period to acquire recent pump data. The recent pump data is compared to historical pump data, which is or includes pump inlet pressure measured over a historical time period preceding the recent time period. Based on the comparison, a determination is made as to whether tip seal maintenance for the scroll pump and/or further diagnosis of the scroll pump is required. If so, a user-interpretable output may be produced, indicating that tip seal maintenance and/or further diagnosis is required.
F04C 18/02 - Pompes à piston rotatif spécialement adaptées pour les fluides compressibles du type à engrènement, c.-à-d. avec un mouvement de translation circulaire des organes coopérants, chaque organe possédant le même nombre de dents ou de parties équivalentes de prise
F04C 27/00 - Systèmes d'étanchéité dans les pompes à piston rotatif spécialement adaptées pour les fluides compressibles
F04C 28/06 - Commande, surveillance ou dispositions de sécurité pour les pompes ou les installations de pompage spécialement adaptées pour les fluides compressibles spécialement adaptées pour arrêter, pour démarrer, pour le ralenti ou pour un fonctionnement à charge nulle
5.
LIQUID DISPENSING WITH REDUCED DROPLET EVAPORATION
Liquids are dispensed onto a substrate in a manner that reduces droplet evaporation while and after the liquids are dispensed. The substrate is at least partially enclosed by boundaries that form a chamber that is effective to reduce the rate of evaporation of droplets being dispensed. The chamber may be partially open to a surrounding environment. Additional evaporative liquid may be provided to assist in reducing the rate of evaporation. The liquid dispensing may be implemented, for example, as part of the fabrication of a microarray such as a chemical or biochemical array, which may be the product of DNA or RNA array printing.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
6.
SYSTEM AND METHOD FOR AUTO-DETECTION OF SPECTROMETER SAMPLE ACCESSORY
Embodiments of the present invention are directed to a sample compartment sub-assembly for a spectrometer. The sub-assembly includes a sample support adapted to support one or more sample holders for use in the sample compartment. The sample support is associated with one or more magnets. The sub-assembly further includes a sensor assembly configured to detect the one or more magnets associated with the sample support so as to identify a mode of operating the spectrometer corresponding to the sample support.
G01N 21/01 - Dispositions ou appareils pour faciliter la recherche optique
G01N 21/31 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique
7.
APPARATUS AND METHOD FOR DETERRING A THIRD PARTY FROM COPYING A PRODUCT OR PROCESS
In some examples, deterring a third party from copying a product or process may include scanning code to generate scanned code. Text in the scanned code may be read and/or at least one image in the scanned code may be recognized. The text and/or the at least one image may be analyzed to determine whether the code includes a specified trademark. Based on a determination that the code includes the specified trademark, an indication of authenticity of the code may be generated.
G06V 20/00 - ScènesÉléments spécifiques à la scène
G06K 7/14 - Méthodes ou dispositions pour la lecture de supports d'enregistrement par radiation électromagnétique, p. ex. lecture optiqueMéthodes ou dispositions pour la lecture de supports d'enregistrement par radiation corpusculaire utilisant la lumière sans sélection des longueurs d'onde, p. ex. lecture de la lumière blanche réfléchie
G06V 10/74 - Appariement de motifs d’image ou de vidéoMesures de proximité dans les espaces de caractéristiques
G06V 30/19 - Reconnaissance utilisant des moyens électroniques
An autoclaving microplate washing system for cells and non-adhering three-dimensional (3D) cell cultures includes one or more pumps for controlling the dispensing of washing fluid and the evacuation of fluid from microwells to gently wash the cells. A method of controlling the autoclaving microplate washing system includes controlling the one or more pumps for dispensing and evacuation.
B01L 9/00 - Dispositifs de supportDispositifs de serrage
B05B 1/14 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage avec des orifices de sortie multiplesBuses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage avec des filtres placés dans ou à l'extérieur de l'orifice de sortie
B05B 9/04 - Appareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides, n'impliquant pas de mélange avec des gaz ou des vapeurs caractérisés par les moyens d'alimentation en liquide ou en autre matériau fluide comportant un réservoir sous pression ou compressibleAppareillages de pulvérisation pour débiter des liquides ou d'autres matériaux fluides, n'impliquant pas de mélange avec des gaz ou des vapeurs caractérisés par les moyens d'alimentation en liquide ou en autre matériau fluide comportant une pompe
B08B 3/02 - Nettoyage par la force de jets ou de pulvérisations
B08B 11/02 - Dispositifs pour maintenir les objets pendant le nettoyage
F04B 13/00 - Pompes spécialement modifiées pour débiter des quantités fixes ou prédéterminées
F04B 23/06 - Combinaisons de plusieurs pompes les pompes étant toutes du type à déplacement positif alternatif
F04B 27/04 - Pompes multicylindres spécialement adaptées aux fluides compressibles et caractérisées par le nombre ou la disposition des cylindres ayant des cylindres disposés en étoile ou en éventail
G01N 15/01 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux spécialement adaptée aux cellules biologiques, p. ex. aux cellules sanguines
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
9.
DEGASSER WITH TWO WEAKLY COUPLED SPACES AND/OR WITH A RESTRICTION ADJUSTMENT DEVICE
A degasser for degassing a mobile phase includes a degasser chamber with a degasser volume for receiving a degassing membrane, a delimiting unit for delimiting a first space of the degasser volume with respect to a second space of the degasser volume while maintaining a fluid connection between the first space and the second space. The first space in an operation in an environment of the degassing membrane includes a higher partial pressure of vapor of the mobile phase than the second space with a lower partial pressure of vapor of the mobile phase. The degasser further includes a suction unit for sucking a gas that passed through the degassing membrane from the second space, and/or an associated gas supply unit for supplying an associated gas in the second space or in a fluid conduit that is connected to the second space.
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
Biopolymers are synthesized on a substrate in a manner that that reduces droplet evaporation including at elevated temperatures. The substrate is enclosed by a lid that form an incubation chamber that is effective to impair evaporation of droplets being dispensed and to provide vapor and temperature adjustments. The biopolymer synthesis may be implemented, for example, as part of the fabrication of a microarray which may be the product of DNA or RNA array printing and for oligonucleotide library synthesis, by chemical and enzymatic procedures.
Evaluating immune and cancer cells is provided for by assessing cytolysis of cancer cells by effector cells, which includes: providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, wherein the device comprises a well for receiving cells and an electrode array at a base of the well, the device further operably connected to an imaging unit; b) adding target cells characterized as cancer cells to the well; c) disposing a layer comprising an extracellular matrix (ECM) over the target cells; d) adding effector cells over the ECM layer; and e) imaging the well and monitoring cell-substrate impedance of the well to determine invasion of the effector cells through the ECM layer and effectiveness of effector cell killing of the target cells either directly or via migration and invasion through extracellular matrix.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/483 - Analyse physique de matériau biologique
12.
IMMOBILIZED IONIC LIQUID -SILOXANE HYBRID STATIONARY PHASE FOR GAS CHROMATOGRAPHY
Chromatography columns are disclosed. The column includes a coating on an inner surface. The coating on the inner surface includes a cross-linkable reactive polymer and ionic functional groups. The cross -linkable reactive polymer has one or more functional groups that are attached to the inner surface. Chromatography systems including columns are disclosed. Methods of adjusting the selectivity of chromatography columns with ionic functional groups are also disclosed.
B01J 41/20 - Échangeurs d'anions pour procédés chromatographiques
B01J 47/022 - Procédés sur colonne ou sur lit caractérisés par la fabrication de la colonne ou du contenant
B01J 20/285 - Absorbants ou adsorbants poreux à base de polymères
B01D 15/20 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement de la matière adsorbante ou absorbante
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
An apparatus for optically analyzing a sample may include an imaging subsystem that images the sample, one or more analyzing subsystems that analyze the sample including a confocal imaging subsystem, a temperature control subsystem that controls a temperature of the atmosphere within the apparatus, a gas control subsystem that controls a composition of the atmosphere within the apparatus, and a control module that controls the various subsystems of the apparatus.
In some examples, an ion mobility spectrometry apparatus may include a plurality of printed circuit boards (PCBs). Each PCB of the plurality of PCBs may include a cutout. A plurality of electrodes may be disposed within at least a portion of the cutout for each PCB of the plurality of PCBs. Further, the plurality of PCBs may be stacked such that the plurality of electrodes are arranged to define an ion channel.
A wellplate is disclosed containing a significant number of individual wells for holding and testing biological samples. In order to maintain homeostatic conditions within each well, the wellplate includes a moat that surrounds a perimeter of the wells. The moated wellplate is designed to be efficiently filled with fluids without causing fluid spills. Once filled with fluids, the moat prevents temperature gradients and different evaporation rates from occurring within the individual wells.
Systems and methods for a gas chromatography mass spectrometry fitting are described herein. An assembly can include a first fitting having a first flat surface, a first conduit, and a protrusion. The assembly can include a ferrule having a frustoconical surface, a second flat surface, and a second conduit. The second flat surface can be sealed against the protrusion. The assembly can include a tube disposed in the first conduit and the second conduit. The second conduit can define an interior surface of the ferrule. The interior surface of the ferrule can seal against an outer surface of the tube.
In some examples, linear and non-linear range-based plot pane selection may include receiving data that is to be displayed. Based on an increase or a decrease in a size of a range selector, a selection of a range of plot panes may be received from a plurality of available plot panes to display the data. Based on the received selection of the range of plot panes, a display of the data may be generated in plot panes included in the range of plot panes. The size of the range selector may be non-linearly proportional to the available plot panes to display the data.
G06F 3/0482 - Interaction avec des listes d’éléments sélectionnables, p. ex. des menus
G06F 3/04845 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] pour la commande de fonctions ou d’opérations spécifiques, p. ex. sélection ou transformation d’un objet, d’une image ou d’un élément de texte affiché, détermination d’une valeur de paramètre ou sélection d’une plage de valeurs pour la transformation d’images, p. ex. glissement, rotation, agrandissement ou changement de couleur
18.
HIGH THROUGHPUT, FLUORESCENCE-BASED ESTIMATION OF MONOCONAL ANTIBODY AGGREGATION WITH DISODIUM 3,3'-{[(E)-1,2-DIPHENYL-1,2-ETHENEDIYL]BIS(4,1-PHENYLENEOXY)}DI (1-PROPANESULFONATE) DYE FOR SUPERIOR SENSITIVITY AND SPECIFICITY
The disclosure teaches a high-throughput, fluorescence-based assay for rapid, semi-quantitative estimation of high-molecular weight aggregation in mAb samples. The method rapidly estimates mAb aggregation.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
19.
SYSTEMS AND METHODS FOR A GAS CHROMATOGRAPHY MASS SPECTROMETRY FITTING
Systems and methods for a gas chromatography mass spectrometry fitting are described herein. An assembly can include a first fitting having a first flat surface, a first conduit, and a protrusion. The assembly can include a ferrule having a frustoconical surface, a second flat surface, and a second conduit. The second flat surface can be sealed against the protrusion. The assembly can include a tube disposed in the first conduit and the second conduit. The second conduit can define an interior surface of the ferrule. The interior surface of the ferrule can seal against an outer surface of the tube.
B01D 53/02 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par adsorption, p. ex. chromatographie préparatoire en phase gazeuse
The present invention provides compositions and methods for inducing CRISPR/Cas-based editing of a target nucleic acid (e.g., target DNA or target RNA), or modulating the expression of a target nucleic acid, in vitro or in a cell, using modified guide RNAs (gRNAs) that incorporate one or more chemically-modified nucleotides. In some aspects, these modified gRNAs provide superior performance under challenging conditions.
Systems and methods for analysis of samples(217), the method can include providing a sample loop (225)disposed between a first valve(210)and a second valve(215); providing a pump(230) disposed downstream of the second valve(215); providing a sample container(245) disposed upstream of the first valve(210); engaging the pump(230) at a first time to modify a pressure inside the sample loop(225) from a first pressure to a second pressure less than the first pressure; opening the first valve(210) at a second time subsequent to the first time to flow a sample (217)through the first valve(210) into the sample loop(225). The pump(230)can be configured to remain fluidically connected to the sample loop(225) and turned on at the second time.
Systems and methods for analysis of samples are described herein. The method can include providing a sample loop disposed between a first valve and a second valve. The method can include providing a pump disposed downstream of the second valve. The method can include providing a sample container disposed upstream of the first valve. The method can include engaging the pump at a first time to modify a pressure inside the sample loop from a first pressure to a second pressure less than the first pressure. The method can include opening the first valve at a second time subsequent to the first time to flow a sample through the first valve into the sample loop. The pump can be configured to remain fluidically connected to the sample loop and turned on at the second time.
In some examples, an apparatus may include a leak-detection sensor circuit, at least one hardware processor, and a memory storing machine-readable instructions that, when executed by the at least one hardware processor, cause the at least one hardware processor to receive, from the leak-detection sensor circuit, sampled leak-detection data for a potential leak. The machine-readable instructions, when executed by the at least one hardware processor, further cause the at least one hardware processor to process the sampled leak-detection data with respect to noise and signal fluctuations, determine, based on the processed sampled leak-detection data, a first derivative and a second derivative, and generate, based on the first derivative and the second derivative, an indication of whether the potential leak represents an actual leak.
G01M 3/16 - Examen de l'étanchéité des structures ou ouvrages vis-à-vis d'un fluide par utilisation d'un fluide ou en faisant le vide par détection de la présence du fluide à l'emplacement de la fuite en utilisant des moyens de détection électrique
The disclosure provides binding agents (e.g., antibodies) against a human Claudin-18.2 protein, as well as kits and methods for using the same (e.g., immunoassays) as part of a companion diagnostic and for other applications. In some aspects, the binding agents described herein may be used in assays for detecting, e.g., a pancreatic cancer, a gastric cancer, a colo-rectal cancer, an ovarian carcer, a lung cancer, or an esophageal cancer.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
An ion pump is equipped with a monitoring system that, by monitoring the temperature present inside the ion pump, makes it possible to determine whether the ion pump is in an OFF state or an ON state while an electric potential difference is being applied between the pump electrodes. The monitoring system further makes it possible to assess the ON state or OFF state of the ion pump even when the ion pump is operating under low-pressure conditions, with an electric current below the minimum value detectable by conventional reading scales. A method for operating the ion pump utilizes the monitoring system to assess the ON/OFF state of the ion pump while an electric potential difference is being applied between the pump electrodes.
The present invention provides methods and kits to improve the signal from sialic acids labeled with the dye 1, 2-diamino-4, 5-methylenedioxybenzene (“DMB”). The methods include labeling the sialic acids with DMB in an aqueous solution comprising the amino acid glycine, with pH adjusted to 1.5-3.2 by an acid, such as phosphoric acid or hydrochloric acid, and a reductant.
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
27.
Display screen or portion thereof with graphical user interface for instrument connect control
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Manufacturing services for others in the field of drugs for
therapeutic use in humans, nucleic acids, and nucleic acid
materials; custom manufacturing consultancy; technical
support services, namely, providing technical advice related
to the manufacture of drugs for therapeutic use in humans,
nucleic acids, and nucleic acid materials.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Software for laboratory instruments sold as an integral
component of gas chromatography instruments, namely,
downloadable and recorded computer software and firmware for
automated system readiness, for instrument operation, for
predictive monitoring that tracks usage and provides alerts
when maintenance is needed, for instrument maintenance and
troubleshooting, and for providing a user interface at the
instrument touchscreen and via a network connected web
browser.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing temporary use of non-downloadable cloud-based
software as a service to facilitate the interaction and
management of laboratory instruments, scientific data and
business process electronic data; providing temporary use of
non-downloadable cloud-based software for controlling
laboratory instruments, collecting, analyzing, interpreting,
and managing laboratory data, and creating and exporting
reports; providing temporary use of non-downloadable
computer software for use in research and diagnostic
laboratories for laboratory automation, visualization, data
reporting and analysis.
31.
ANALYSIS DEVICE WITH PARALLEL OPERATION OF SECONDARY FUNCTIONS
An analysis device, in particular for a sample separation device, for performing an analysis, is configured for executing a primary function which is directly associated with performing the analysis, and executing a first secondary function and a second secondary function which are indirectly associated with performing the analysis. The first secondary function and the second secondary function are performed at least temporarily in parallel with one another.
A method for operating an analysis device, in particular a sample separation device, for performing an analysis includes setting a determined equilibrium value as a control value for a controlled variable of the analysis device, the equilibrium value having been determined in advance by controlling at least one control variable of the analysis device to a target value and determining the resulting equilibrium value of a controlled variable of the analysis device in response to the controlling of the at least one control variable. The method also includes controlling the at least one control variable to the target value such that the control value of the controlled variable is complied with in the process.
In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter. The first gasket and the second gasket may include a beveled surface adjacent to the filter. The first channel and the second channel may include a diameter of from about 0.01 mm to about 0.5 mm. A finger tightening system may securely hold the filter without any leaks.
B01D 15/12 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la préparation de l'alimentation
B01D 15/22 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la structure de la colonne
B01D 15/26 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation
B01D 29/58 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants à plusieurs éléments filtrants caractérisés par leur agencement relatif montés en série disposés de façon concentrique ou coaxiale
A pressure sensor includes an electromechanical element, which is configured to change its shape depending on a pressure applied to the pressure sensor and to output an electromagnetic characteristic that is based on the shape change. The pressure sensor also includes frame element with a surface, against which the electromechanical element is pressed by the applied pressure to cause the shape change.
G01L 9/00 - Mesure de la pression permanente, ou quasi permanente d’un fluide ou d’un matériau solide fluent par des éléments électriques ou magnétiques sensibles à la pressionTransmission ou indication par des moyens électriques ou magnétiques du déplacement des éléments mécaniques sensibles à la pression, utilisés pour mesurer la pression permanente ou quasi permanente d’un fluide ou d’un matériau solide fluent
G01L 19/06 - Moyens pour empêcher la surcharge ou l'influence délétère du milieu à mesurer sur le dispositif de mesure ou vice versa
Systems and methods for measuring light, which collect and measure light emitted from different positions along the length of a flow cell using shared collection and magnification optics, a light splitting module that splits magnified light into a plurality of wavelength ranges, and an array of spherical lenses that direct light of different wavelength and emission position to an array of detectors.
Systems and methods for modular fluidic systems and methods for parallel capillary electrophoresis are described herein. The system can include a housing, a manifold assembly, and a reservoir assembly. The manifold assembly can include a manifold connector. The reservoir assembly can include a reservoir and a reservoir connector. In a first configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a first volume. In a second configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a second volume different from the first volume.
Aspects of the present disclosure provide methods for determining the eligibility of a subject having a malignancy for treatment with an anti-PD therapeutic agent based on a Combined Positive Score (CPS) for a tumor tissue sample from the subject. Compositions and kits or performing the disclosed methods are also provided.
Systems and methods for modular fluidic systems and methods for parallel capillary electrophoresis are described herein. The system can include a housing, a manifold assembly, and a reservoir assembly. The manifold assembly can include a manifold connector. The reservoir assembly can include a reservoir and a reservoir connector. In a first configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a first volume. In a second configuration, the manifold assembly can couple with the reservoir assembly including the reservoir having a second volume different from the first volume.
A resin formed of copolymer beads is disclosed. The copolymer beads have a first repeating motif, a second repeating motif having a substituted styrene with an ester functional group or an amide with a terminal amine or hydroxyl functional group, and a crosslinking agent having a divinyl compound. The copolymer beads are capable of expanding substantially uniformly in polar and non-polar solvents.
C08F 212/14 - Monomères contenant un seul radical aliphatique non saturé contenant un cycle substitué par des hétéro-atomes ou des groupes contenant des hétéro-atomes
C07H 21/00 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques
C07H 1/00 - Procédés de préparation des dérivés du sucre
C07H 19/073 - Radicaux pyrimidine avec un désoxy-2 ribosyle comme radical saccharide
C07H 19/167 - Radicaux purine avec un ribosyle comme radical saccharide
40.
METHODS OF ANALYZING LIPID NANOPARTICLES IN PHYSIOLOGICAL FLUIDS
G01N 30/88 - Systèmes intégrés d'analyse, spécialement adaptés à cet effet, non couverts par un seul des groupes
G01N 33/92 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des lipides, p. ex. le cholestérol
An interference ion removal device used in a mass spectrometry system or the like comprises a first ion guide and a second ion guide, a DC potential barrier being formed between the first ion guide and the second ion guide. In the first ion guide, collision-induced dissociation (CID) and kinetic energy discrimination (KED) are performed, and in the second ion guide, the velocity distribution of ions is caused to converge.
The disclosure provides binding agents (e.g., antibodies) against a human Hepatitis A virus cellular receptor 2 protein (TIM3), as well as kits and methods for using the same (e.g., immunoassays) as part of a companion diagnostic and for other applications. In some aspects, the binding agents described herein may be used in assays for detecting Non-Small Cell Lung Cancer (NSCLC) and/or other types of lung cancer, Head and Neck Squamous Cell Carcinoma (HNSCC), Hepatocellular Carcinoma (HCC) or other types of liver cancer, Renal cell carcinoma, malignant melanoma, gastro-intestinal cancer, colorectal cancer, urothelial carcinoma and other types of bladder cancer, mamma carcinoma and/or other types of breast cancer, ovarian cancer, cervical cancer, prostate cancer, pancreatic cancer, lymphoma/leukemia, malignant mesothelioma, or a cancer in another organ or cell type.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
The invention relates to a liquid detector (100) for an analysis device (10), wherein the liquid detector (100) has: i) a temperature sensor device (120) for determining a temperature characteristic (132) over time in response to a provided temperature pulse (131); and, ii) an evaluation device (130) for evaluating a liquid characteristic on the basis of the determined temperature characteristic (132).
G01N 25/02 - Recherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant les changements d'état ou de phaseRecherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant le frittage
G01N 30/30 - Contrôle des paramètres physiques du fluide vecteur de la température
45.
ELECTROACTIVE CHAMBER PUMP SYSTEM AND METHOD FOR OPERATING THE SAME
ZEMA ZENTRUM FÜR MECHATRONIK UND AUTOMATISIERUNGSTECHNIK GGMBH (Allemagne)
AGILENT TECHNOLOGIES, INC. (USA)
Inventeur(s)
Ziegler, Tony
Wagner, Joachim
Plachetka, Clemens
Baltes, Matthias
Croce, Sipontina
Motzki, Paul
Abrégé
Chamber pump system comprising at least one chamber pump (1) comprising a deformable chamber membrane (8) defining a pump chamber (9), an electroactive elastomer transducer (13) mechanically coupled with the chamber membrane (8) to actuate the chamber membrane to change the volume of the pump chamber (9), and a control unit (15) for periodically energizing the electroactive elastomer transducer (13) to induce a reciprocating motion of the chamber membrane (8) according to an actuation frequency; wherein the control unit (15) is configured to set the actuation frequency depending on at least one of an operating pressure and a total electrical power consumption.
F04B 35/04 - Pompes à piston spécialement adaptées aux fluides compressibles et caractérisées par les moyens d'entraînement de leurs organes de travail ou par leur combinaison avec les machines motrices ou moteurs qui les entraînent ou bien par leurs adaptations à cet effet, non prévues ailleurs les moyens étant électriques
F04B 43/00 - "Machines", pompes ou installations de pompage ayant des organes de travail flexibles
F04B 43/04 - Pompes ayant un entraînement électrique
09 - Appareils et instruments scientifiques et électriques
Produits et services
Software for laboratory instruments sold as an integral component of gas chromatography instruments, namely, downloadable and recorded computer software and firmware for automated system readiness, for instrument operation, for predictive monitoring that tracks usage and provides alerts when maintenance is needed, for instrument maintenance and troubleshooting, and for providing a user interface at the instrument touchscreen and via a network connected web browser
47.
Smartphone display screen or portion thereof with transitional graphical user interface for instrument run control
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory equipment for preparing samples for life science
research, namely, apparatus and instruments for automated
liquid handling, fluidics and sample storage, sample
transfer, and downloadable and recorded software for
equipment operation and control and for the transfer and
sharing of data.
A detector for an analytical device for analyzing a fluidic sample includes a housing, a lamp seat arranged in the housing and configured to receive a lamp for generating an electromagnetic radiation, and a movement mechanism to swivel the lamp seat with respect to the housing, and/or move the lamp seat between an operating orientation and a service orientation, so that the movement from the service orientation to the operating orientation results automatically in an electric contact and/or a mechanical positioning, in particular alignment, of the lamp.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
(1) Manufacturing services for others in the field of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials; custom manufacturing consultancy; technical support services, namely, providing technical advice related to the manufacture of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials.
51.
ANTI-HUMAN ICOS ANTIBODIES FOR USE IN IMMUNOHISTOCHEMISTRY (IHC) PROTOCOLS AND FOR DIAGNOSING CANCER
In alternative embodiments, provided are chimeric, synthetic or recombinant anti-human ICOS protein or polypeptide (also called inducible T-cell co-stimulator, or Cluster of Differentiation-278, or CD278) antibodies (Abs), including products of manufacture and kits comprising them, and methods for making and using them, including for example their use in the detection or diagnosis, and treatment, of a cancer, or other diseases or conditions involving expression of ICOS. In alternative embodiments, anti-ICOS proteins (for example, antibodies) as provided herein are used together with an agent for determining whether ICOS expression or activity is present, increased, reduced or absent. In alternative embodiments, anti-ICOS antibodies as provided herein are used in the diagnosis and/or treatment of a cancer or a tumor.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
In some examples, a multipole ion guide may include a plurality of electrode groups that are arranged circumferentially around an axis of the multipole ion guide. At least one electrode group of the plurality of electrode groups may include at least three electrodes that are disposed in a side-by-side configuration.
The present disclosure relates to hybridization buffers for use in hybridization, for example, for use in in situ hybridization (ISH). Hybridization buffers and compositions comprising a sulfone solvent and polyvinyl sulfonic acid or a salt thereof, and methods of making and using, the same are disclosed.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Manufacturing services for others in the field of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials; Manufacturing process consulting; Technical support services, namely, providing technical advice related to the manufacture of drugs for therapeutic use in humans, nucleic acids, and nucleic acid materials
In some examples, a multipole ion guide may include a plurality of electrode groups that are arranged circumferentially around an axis of the multipole ion guide. At least one electrode group of the plurality of electrode groups may include at least three electrodes that are disposed in a side-by-side configuration.
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing non-downloadable cloud-based software as a service services featuring software to facilitate the interaction and management of laboratory instruments, scientific data and business process electronic data; Providing non-downloadable cloud-based software for controlling laboratory instruments, collecting, analyzing, interpreting, and managing laboratory data, and creating and exporting reports; Providing online non-downloadable computer software for use in research and diagnostic laboratories for laboratory automation, visualization, data reporting and analysis
A coated capillary tube having a tunable resistance in an ion transfer device, including an inlet end in communication with an atmospheric-pressure ion source, an outlet end in communication with a vacuum region of a mass spectrometer, a body elongated along an axis from the inlet end to the outlet end, and an inside surface defining a bore having an inner diameter is disclosed. The coated capillary tube also includes a resistive coating on the inside surface of the capillary tube, in which the resistive coating includes at least one layer comprising oxides or nitrides of a metal and discrete metal particles of a different metal embedded therein.
C09D 1/00 - Compositions de revêtement, p. ex. peintures, vernis ou vernis-laques, à base de substances inorganiques
C23C 16/04 - Revêtement de parties déterminées de la surface, p. ex. au moyen de masques
C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
58.
VIRTUAL STAIN MULTIPLEXING MODEL ARCHITECTURE FOR CHANGEABLE STAINING COLOR
The present disclosure relates to methods and apparatuses for generating virtual staining for an image of a biologic sample. Such virtual staining comprises obtaining a virtual stain concentration image including applying an artificial intelligence model to the image of a biologic sample. Moreover, a staining control parameter is set. Then, a virtual stain image is generated by processing the virtual stain concentration image according to the staining control parameter. In some exemplary implementations, there may be more than one virtual stain image generated using different respective staining control parameters. The generated virtual stain image(s) may be combined with the original (unstained image) to obtain a stained image.
Disclosed herein are methods of purifying oligonucleotides, for example, by separating double-stranded oligonucleotides from single-stranded oligonucleotides. Also provided are apparatuses for performed such methods. Also provided are double-stranded nucleic acid compositions and single-stranded nucleic acid compositions made using the methods and apparatuses disclosed herein. Also provided are methods of producing circular double-stranded nucleic acids.
An analytical device includes a fluid compartment configured to accommodate a solvent, a blocking device configured to close an input and/or an output of the fluid compartment, a flow sensor and/or a pressure sensor coupled to the fluid compartment and configured to perform a measurement with respect to the solvent, a temperature change device coupled to the fluid channel and configured to perform a temperature change with respect to the fluid compartment, and a determination device, configured to determine a thermal property of the solvent based on the measurement and the temperature change.
G01N 11/00 - Recherche des propriétés d'écoulement des matériaux, p. ex. la viscosité, la plasticitéAnalyse des matériaux en déterminant les propriétés d'écoulement
61.
SAMPLE HANDLER WITH STATIONARY OPTICAL SENSOR AND MOVABLE OPTICAL ADAPTER FOR ADAPTING A SENSOR VIEW
A sample handler for handling a sample container includes a stationary optical sensor, a movable stage movable with respect to the stationary optical sensor, and an optical adapter arrangeable at the movable stage and configured for being moved by the movable stage to thereby adapt a view of the stationary optical sensor.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
09 - Appareils et instruments scientifiques et électriques
Produits et services
(1) Laboratory equipment for preparing samples for life science research, namely, apparatus and instruments for automated liquid handling, fluidics and sample storage, sample transfer, and downloadable and recorded software for equipment operation and control and for the transfer and sharing of data.
Systems for performing two-dimensional chromatography are disclosed. The system includes a first switching valve fluidly coupled to a first separation column. The system includes a second switching valve coupled to a second separation column. The second switching valve is fluidly coupled to the first switching valve. The system includes an input/output valve in fluid communication with the first switching valve and the second switching valve that is configured to direct one or more mobile phases to the first switching valve. The system includes a sampling valve fluidly coupled to the first switching valve that includes at least one fraction capturing device. Methods of separating compounds using the systems are disclosed. Methods of retrofitting existing two-dimensional chromatography systems are also disclosed.
G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
B01D 15/16 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives au conditionnement du fluide vecteur
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
B01D 15/40 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation utilisant un fluide supercritique comme phase mobile ou comme éluant
Systems for performing two-dimensional chromatography are disclosed. The system includes a first switching valve fluidly coupled to a first separation column. The system includes a second switching valve coupled to a second separation column. The second switching valve is fluidly coupled to the first switching valve. The system includes an input/output valve in fluid communication with the first switching valve and the second switching valve that is configured to direct one or more mobile phases to the first switching valve. The system includes a sampling valve fluidly coupled to the first switching valve that includes at least one fraction capturing device. Methods of separating compounds using the systems are disclosed. Methods of retrofitting existing two-dimensional chromatography systems are also disclosed.
B01D 15/14 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à l'introduction de l'alimentation dans l'appareil
B01D 15/18 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives aux différents types d'écoulement
G01N 30/46 - Modèles d'écoulement utilisant plus d'une colonne
G01N 30/20 - Injection utilisant une valve d'échantillonnage
66.
LID FOR SEALING POLYMERASE CHAIN REACTION (PCR) PLATE
In some examples, a lid may include a seal disposed on a bottom surface of the lid. The lid may include a top surface and the bottom surface. The lid may further include a plurality of springs formed on the seal, where at least one spring of the plurality of springs includes a cylindrical configuration.
In some examples, an apparatus may include an environmental sample analyzer that is executed by at least one hardware processor to analyze an environmental sample at a plurality of wavenumbers. A particle type identifier that is executed by the at least one hardware processor may isolate, based on the analysis of the environmental sample at the plurality of wavenumbers, particle types for a plurality of particles in the environmental sample.
G01N 15/0227 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’imagerieRecherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques utilisant l’holographie
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné
In some examples, a liquid chromatography (LC) preparative guard cartridge housing may include an inlet assembly. Further, the cartridge housing may include an outlet jaw assembly that is slidably and rotateably engageable with the inlet assembly to retain a cartridge between the inlet assembly and the outlet jaw assembly, and disengageable from the inlet assembly to release the cartridge.
B01D 15/22 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à la structure de la colonne
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable and recorded software for managing and
optimizing laboratory pathology workflows, namely, for
capturing and retrieving data from laboratory information
systems, laboratory instruments, and sample tracking
devices, for analyzing, storing, disseminating, and
reporting that data, for presenting and viewing that data in
dashboards, and for inventory management and workflow
optimization. Software as a service (SAAS) services featuring software for
managing and optimizing laboratory pathology workflows,
namely, for capturing and retrieving data from laboratory
information systems, laboratory instruments, and sample
tracking devices, for analyzing, storing, disseminating, and
reporting that data, for presenting and viewing that data in
dashboards, and for inventory management and workflow
optimization.
70.
FLEXIBLE CAPILLARY ARRAY DEVICE AND RELATED SYSTEMS AND METHODS
A capillary array device includes a flexible component allowing movement of at least part of the device relative to an array of capillaries, thereby allowing different materials to be loaded into the capillaries. The capillaries may be utilized to contain samples that are to be measured by a capillary electrophoresis (CE) instrument or other type of analytical instrument.
A method and system for seeding cells on a well plate is disclosed. According to the present disclosure, a cell concentrating device is used that positions the cells at a particular location on the bottom floor of each well. The cell concentrating device improved sensitivity and uniformity when conducting analysis on the cells.
The invention provides a sample delivery system for an analytical instrument, comprising: a valve assembly comprising one or more valves, the valve assembly configured to receive an external sample from a sample source; an external sample reservoir coupled via the valve assembly to a sample dilution junction, wherein the valve assembly is configurable to alternatively permit either (i) flow of the external sample from the sample source to the external sample reservoir or (ii) flow of the external sample from the external sample reservoir to the sample dilution junction; a first fluid pump to control a flow of the external sample from the external sample reservoir to the sample dilution junction; a second fluid pump to control a flow of diluent to the sample dilution junction, thereby diluting the external sample to produce a diluted sample; and an analysis sample reservoir configured to deliver an analysis sample contained therein to an analysis device of the analytical instrument, wherein the analysis sample reservoir is coupled via the valve assembly to the sample dilution junction, and wherein the valve assembly is configurable to alternatively permit either (i) flow of the external sample along a continuous flow path from the sample source to the analysis sample reservoir, thereby by-passing the external sample reservoir, or (ii) flow of the diluted sample from the sample dilution junction to the analysis sample reservoir.
G01N 1/38 - Dilution, dispersion ou mélange des échantillons
H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
A valve, such as for an analysis device for analyzing a fluidic sample, includes a stator element having a stator boundary surface and a rotor element having a rotor boundary surface. The stator element and the rotor element are arranged in an axial direction. The stator boundary surface and the rotor boundary surface are pressed against each other in the axial direction by an axial force. The axial force is fixed by a non-detachable connection.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Downloadable and recorded software for controlling liquid
chromatography instruments and gas chromatography
instruments, for processing, reviewing, and reporting data
from chromatography instruments, and for viewing and
monitoring the status of laboratory instruments and
laboratory workflows.
In some examples, a multipole ion guide may include a plurality of printed circuit boards (PCBs) that are circumferentially arranged about a central axis to form a conduit. The multipole ion guide may be formed based on utilization of plated edges of the PCBs.
A bearing allows accurate monitoring of bearing conditions and includes a printed circuit board, which is fitted to the bearing and on which one or more sensors are preassembled. The bearing facilitates removal and replacement operations and includes a first electrical cable and a second electrical cable removably connected to each other. The bearing is particularly suitable for applications to rotary vacuum pumps, especially turbomolecular pumps, in which the bearing is under vacuum conditions and the rotating shaft rotates at very high speed, so that high precision in the design and operation of the bearing is required and risks of contamination and/or of losing vacuum tightness must be carefully avoided.
Silica-coated magnetic nanoparticles with greater ability to remain dispersed, and methods of making and using silica-coated magnetic nanoparticles, including incubation of an aqueous dispersion of newly made particles at room temperature for a time period resulting in clusters of silica-coated magnetic nanoparticles, the resulting clusters being of an optimal size for viral RNA extraction from human clinical samples. The magnetic nanoparticles comprise a core and a coating, where the core comprises Fe3O4 or other magnetic material and the coating has a thickness of from about 1.5 nm to about 2 nm. The magnetic nanoparticles are useful for preparing nucleic acids for analysis, by separating nucleic acids from other components and by normalizing nucleic acid concentrations.
The disclosure provides binding agents (e.g., antibodies) against human TIGIT, as well as kits and methods for using the same (e.g., immunoassays) as part of a companion diagnostic and for other applications. In some aspects, the binding agents described herein may be used in assays for detecting ovarian cancer, squamous cell carcinoma of the head and/or neck, non-small cell lung cancer, cervical cancer, esophageal cancer, melanoma, breast cancer, hepatocellular cancer, colorectal cancer, gastric cancer, renal cell carcinoma, prostate cancer, pancreatic cancer, bladder cancer, lymphoma, metastatic cancer, and/or a solid tumor in, on, or derived from any human tissue or organ.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
79.
PEEK-TO-PEEK THERMAL BONDING METHOD FOR PEEK MANIFOLDS
Methods for directly bonding two or more articles of polycthcr ether ketone (PEEK) arc provided. The method includes treating bonding surfaces on the two or more articles of PEEK. The method includes placing the treated bonding surfaces of the two or more articles of PEEK into contact with each other. The method further includes heating the two or more articles of PEEK for a pre-determined time at a pre-determined temperature between 250 °C and the melting point of the PEEK. The method additionally includes applying a pre-determined compressive load to the two or more articles of PEEK during heating. Fluid handling devices, such as manifolds and filters, formed using methods of the disclosure are also disclosed.
C08J 5/12 - Fixation d'un matériau macromoléculaire préformé au même matériau ou à un autre matériau compact, tel que du métal, du verre, du cuir, p. ex. en utilisant des adhésifs
Impedance-based determination of metrics derived from Cytopathic Effects (CPE), such as Tissue Culture Infections Dose (TCID) values, is provided via determining a first plurality of cellular impedances (CI) corresponding to a plurality of cell samples while performing the impedance assay; inoculating the plurality of cell samples with a plurality of different dilutions of the virus such that a first and second subsets of the plurality of cell samples are respectively inoculated with first and second dilutions of a virus; determining, after inoculating the plurality of cell samples, a second plurality of CIs; determining, from the first plurality of CIs and the second plurality of CIs, cytopathic effects (CPE) experienced by the plurality of cell samples; calculating, a CPE-derived metric.
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Downloadable and recorded software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization. (1) Software as a service (SAAS) services featuring software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization.
An analytical device, in particular for analyzing a fluidic sample, includes a fluid drive configured to stream a first solvent and a second solvent along a flow path, so that the first solvent and the second solvent are streamed as a mixture at least during a time period. A determination device is configured to determine a value of a physical parameter with respect to the streaming of the mixture along the flow path, for at least two measurements each with a different mixing ratio of the first solvent and the second solvent, thereby determining at least two measurement results. An evaluation device is configured to compare the at least two determined measurement results with a reference, and to derive an information associated with the first solvent and/or the second solvent based on the comparison.
A degasser for at least partially degassing a gas-containing liquid, in particular for a sample separation device, includes a liquid accommodation volume for accommodating the gas-containing liquid during degassing, a negative pressure chamber in which a negative pressure, compared to the liquid accommodation volume, is to be generated, a gas permeable membrane separating the liquid accommodation volume from the negative pressure chamber and arranged so that ultrasound forces at least part of gas of the gas-containing liquid to move through the membrane by a combination of the negative pressure and the ultrasound, and an ultrasound source including an electroactive material and configured for generating ultrasound for actuating the gas-containing liquid and/or the gas permeable membrane.
A sample probe accessory is disclosed. The sample probe accessory has a cylindrical body portion having an opening on a proximal end dimensioned to fit a distal end of the sample probe. The sample probe accessory has a filter positioned within the cylindrical body portion. The sample probe accessory has a cone portion extending from a distal end of the cylindrical body portion having a bottom aperture on a vertex of the cone portion. Also disclosed is a sample introduction subsystem for a spectrometer, including the sample probe accessory.
G01N 1/10 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
B01D 35/02 - Filtres adaptés à des endroits particuliers, p. ex. conduites, pompes, robinets
86.
POLYETHER ETHER KETONE (PEEK) LINE COLUMN QUICK CONNECT
In some examples, a peek line column connect may include a connector including a peek line bore for insertion of a tube. A fastener may be removably insertable into one end of the connector to retain the tube when the fastener is moved in a first direction to further move a ferrule to contiguously engage the connector, and release the tube when the fastener is moved in a second direction that is opposite to the first direction to disengage the ferrule from the connector.
A method and system are disclosed for measuring a constituent of a sample. In one aspect, the sample can be a biological material. The method and system place a sensor in association with a sample. Excitation light is shown onto the sensor and a signal is detected from the sensor. A lens structure is positioned between the light source and the sensor for improving uniformity, intensity, and/or accuracy of the detected signal.
G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Downloadable and recorded software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization Software as a service (SAAS) services featuring software for managing and optimizing laboratory pathology workflows, namely, for capturing and retrieving data from laboratory information systems, laboratory instruments, and sample tracking devices, for analyzing, storing, disseminating, and reporting that data, for presenting and viewing that data in dashboards, and for inventory management and workflow optimization
89.
COLLET, DEVICES, AND METHODS FOR INSTALLATION OF FLUIDIC CONDUITS TO FLUIDIC COMPONENTS
A collet includes a cap, a conduit grasper, a collet bore, and a collet slot. The grasper is composed of a flexible material such that the grasper is compressible in response to an applied force. A conduit such as a column is installed in a fluidic component by passing the conduit through the collet and into a fluidic coupling device. The collet is then coupled to the fluidic coupling device so as to compress the grasper against the column, thereby securing the column in the fluidic coupling device. The conduit may then be inserted into the fluidic component, and fluidic coupling device may be coupled to the fluidic component to complete the conduit installation. The collet or at least the cap may then be removed by moving the collet or at least the cap around the column via the collet slot. The grasper may be removed via a grasper slot.
Pipetting systems, devices, and methods are disclosed. An automated pipettor includes a pipette tip, a syringe, and a pressure sensor. The pipette tip is to aspirate a fluid from a container and/or dispense the fluid onto a target surface. The syringe is fluidically connected to the pipette tip. The pressure sensor is to collect pressure data. The pressure data is indicative of an air pressure in the pipette tip and/or the syringe. A processor is configured to determine the air pressure throughout the aspiration event and/or the dispensing event based on the pressure data. The processor is configured to identify when the fluid being aspirated is liquid or air based on changes in the air pressure during an aspiration event. The processor is configured to identify when the fluid being dispensed is liquid or air based on changes in the air pressure during a dispensing event.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
The present disclosure relates to chromogenic conjugates including a chromogenic moiety and a peroxidase substrate moiety, methods of chromogenic analysis, such as ImmunoHistoChemistry (IHC) and Chromogen In Situ Hybridization (CISH), and methods of making chromogenic conjugates.
C12Q 1/28 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase une peroxydase
C12Q 1/26 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une oxydoréductase
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/535 - Production de composés immunochimiques marqués avec un marqueur enzymatique
C09B 11/24 - Phtaléines contenant des groupes amine
C09B 69/10 - Colorants polymèresProduits de réactions de colorants avec des monomères ou avec des composés macromoléculaires
C09B 23/08 - Colorants méthiniques ou polyméthiniques, p. ex. du type cyanine caractérisés par la chaîne méthinique contenant un nombre impair de groupes CH plus de trois groupes CH, p. ex. polycarbocyanines
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Custom manufacturing in the field of biopharmaceuticals and pharmaceuticals; contract manufacturing in the biotechnology field, namely, fill and finish of biologics and drug substances for others; manufacturing process consulting; providing technical information in the field of pharmaceutical manufacturing.
(2) Development and production of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, medicaments for others; research in the field of biopharmaceuticals and pharmaceuticals; engineering services in the field of biorefining and biomanufacturing processes and consultation related thereto; laboratory services using fermentation for biomanufacturing; biochemical research and analysis; quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of biopharmaceuticals and pharmaceuticals.
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Custom manufacturing of biopharmaceuticals and pharmaceuticals; Manufacturing process consulting; Providing technical information in the field of pharmaceutical manufacturing Development of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, medicaments for others; Research in the field of biopharmaceuticals and pharmaceuticals; Engineering services in the field of biorefining and biomanufacturing processes and consultation related thereto; Laboratory services using fermentation for biomanufacturing; Biochemical research and analysis; Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of biopharmaceuticals and pharmaceuticals
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemical compositions, reagents, chemical additives, and biochemical preparations for use in the manufacture of pharmaceuticals and biopharmaceuticals; Chemical compositions, reagents, chemical additives, and biochemical preparations, all for scientific research use in the fields of pharmaceuticals and biopharmaceuticals Chemical reagents for pharmaceutical purposes; Chemical reagents for medical purposes; Biological reagents for medical purposes; Diagnostic reagents for medical use Custom manufacturing in the field of biopharmaceuticals and pharmaceuticals, namely, chemical additives and reagents; Manufacturing process consulting; Providing technical information in the field of pharmaceutical manufacturing; Custom manufacturing of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, and medicaments for others Development of chemical additives, reagents, pharmaceutical additives, pharmaceuticals, biopharmaceuticals, medicines, medicaments for others; Research in the field of biopharmaceuticals and pharmaceuticals; Engineering services; Laboratory services using fermentation for biomanufacturing; Biochemical research and analysis; Quality management services, namely, quality evaluation and analysis, quality assurance, and quality control, in the field of biopharmaceuticals and pharmaceuticals
09 - Appareils et instruments scientifiques et électriques
Produits et services
downloadable and recorded software for controlling liquid chromatography instruments and gas chromatography instruments, for processing, reviewing, and reporting data from chromatography instruments, and for viewing and monitoring the status of laboratory instruments and laboratory workflows
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory equipment for preparing samples for life science research, namely, laboratory apparatus for automated handling, transfer, and storage of liquid specimens, liquid reagents, and liquid samples; Downloadable and recorded software for controlling the operation of laboratory apparatus for the automated handling, transfer, and storage of liquid specimens, liquid reagents, and liquid samples; Downloadable and recorded software for transferring data to and from automated laboratory apparatus and for the transfer and sharing of data
97.
SAMPLE SEPARATION DEVICE WITH ACTIVELY DAMPING METERING DEVICE
A sample separation device for separating a fluidic sample includes a fluid drive arrangement for driving a mobile phase along a flow path to a sample separation unit, a sampler for sampling the fluidic sample, and a control device configured to control the metering device to thereby actively damp a fluctuation in the fluid drive arrangement operation. The sampler may include a metering device.
B01D 15/14 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement relatives à l'introduction de l'alimentation dans l'appareil
B01D 15/10 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement
98.
METHODS OF PREPARING NUCLEIC ACIDS FOR SEQUENCING AND METHYLATION ANALYSIS
The present invention relates to preparation, sequencing and methylation analysis of nucleic acids. Input nucleic acids are attached, to methylated adaptors or tagged adaptors, or tagged primers are hybridized to the input nucleic acids, and tagged primer extension products are synthesized. Input nucleic acid can be separated from primer extension products or amplicons, and can be treated with a base conversion reagent with or without separation. Target sequences in tagged and untagged nucleic acid molecules can be captured for target enrichment.
The present invention relates to preparation, sequencing and analysis of nucleic acids. The nucleic acids are prepared, by attaching a first tag to an input nucleic acid. The first tag comprises a binding partner of a first binding pair. A second tag comprises a. reciprocal binding partner of the first binding pair. The second tag is attached to the first tag to produce an input nucleic acid complex, thereby indirectly tagging the input nucleic acid with the second tag.
Methods, kits and compositions for selectively tagging RNA molecules and for separating RNA sequences from DNA sequences. Methods for analysis of RNA sequences by preparing tagged cDNA molecules which can be separated from DNA molecules. The DNA molecules can be subjected to different preparation steps than the tagged cDNA molecules.
