A system and method for controlling the flow of aerosols. In some embodiments, a system includes a fluid channel, an actuator, and an actuator drive circuit. The actuator and the actuator drive circuit may be configured to impart vibrations, to a wall of the fluid channel, which produce waves in a gas in the fluid channel and cause aerosols in the gas to be nonuniformly distributed across the interior of the fluid channel, the waves producing a pressure pattern including a plurality of nodes or a plurality of antinodes within the fluid channel.
H01J 49/04 - Dispositions pour introduire ou extraire les échantillons devant être analysés, p. ex. fermetures étanches au videDispositions pour le réglage externe des composants électronoptiques ou ionoptiques
H01J 49/02 - Spectromètres pour particules ou tubes séparateurs de particules Détails
H01J 49/42 - Spectromètres à stabilité de trajectoire, p. ex. monopôles, quadripôles, multipôles, farvitrons
2.
Telmisartan Nanosuspension for Therapy of Respiratory Infections and Methods of Making and Using Same
A method of inhibiting viral replication of a virus in an individual comprising administering an effective amount of a drug nanosuspension combined with a surfactant, wherein the drug nanosuspension combined with the surfactant is delivered to the individual's lungs. Preferably, the drug is a nanosuspension delivered to the individual's lungs through inhalation.
A61K 31/4184 - 1,3-Diazoles condensés avec des carbocycles, p. ex. benzimidazoles
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A larvae aggregation module (100) may include a manufactured body (110) comprising: a substantially rigid material, an outer surface (120); and at least one recess (130) extending into the outer surface, wherein the material, outer surface, and recess are configured to attract and allow attachment and growth of invertebrate larvae thereupon.
Systems and methods for controlling traffic flow along an arterial. The systems comprise a data processing apparatus configured to: monitor traffic light control signals (TLCSs) used to control traffic lights at intersection(s) and traffic delays occurring at intersection(s) at a time when the traffic lights are being controlled by TLCSs; access a hybrid model comprising a first linear term corresponding to an instance of traffic delays, a second linear term corresponding to a concurrent instance of TLCSs, and a nonlinear function defining a nonlinear relationship between the instance of the traffic delays and a previous instance of TLCSs; use the hybrid module to predict traffic delays at intersection(s) based on the traffic control signals and the traffic delays; determine, based on TLCSs and the traffic delays, traffic control signals that cause the predicted traffic delays to decrease; and cause the traffic lights to be controlled using the traffic control signals.
A lightweight radiation shielding material. A carbon nanotube forest is embedded in a matrix comprising nanoparticulates, such as nanoparticles, carbon nanotubes, or graphene nanosheets. The nanoparticulates can be low atomic number (low-Z) or high atomic number (high-Z). The matrix can be a solidified polymer, epoxy, resin, or ceramic precursor, for example silicon carbide. The radiation shield can shield an object from radio frequency interference (RFI), lightning, electromagnetic interference (EMI), an electromagnetic pulse (EMP), gamma rays, X-rays, neutrons, and/or protons. The nanoforest is disposed on a conductive base with sufficient in-plane electrical conductivity to provide an effective conductive path for currents induced by radiation absorption. The base can be a second nanoforest comprising horizontally-oriented carbon nanotubes, which makes the shield particularly lightweight, as low as 10% of the mass of aluminum that provides equivalent shielding. The base can be adhered to an object to be shielded.
Disclosed are evolved Bxb1 and PhiC31 integrases that exhibit increased insertion activity and efficiency as compared to their wild-type counterparts and use of the evolved integrases to modify any sequence within the genome of a cell or subject.
In some examples, anthropometric parameters of a subject are ascertained from radiographic image data. Radiograph image data is transformed to a representation of a lower dimensionality than the dimensionality of the image data by an machine learning processor. The representation of the radio graph image data is mapped to anthropometric parameters, directly or first to an intermediate three-dimensional optical image of the subject, and then from the intermediate three-dimensional optical image to anthropometric parameters.
G06T 3/06 - Mappage topologique de structures de dimension plus élevée sur des surfaces de dimension moins élevée
G06V 10/77 - Traitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source
In some embodiments, a bioimpedance measurement apparatus includes a set of electrodes configured to be placed on respective skin portions of a subject; a temperature sensor probe configured to be placed on a respective skin portion of the subject; a moisture sensor probe configured to be placed on a respective skin portion of the subject; and an electronic module configured to determine an impedance between at least two of the plurality of electrodes, receive from the temperature probe a temperature signal and determine from the temperature signal a temperature of the skin portion the temperature sensor probe is placed on, receive from the moisture sensor probe a moisture signal and determine a moisture level of the skin portion the moisture sensor probe is placed on, and determine a bioimpedance of the subject based at least in part on the determined impedance, temperature, and moisture level.
Disclosed are evolved Bxbl and PhiC31 integrases that exhibit increased insertion activity and efficiency as compared to their wild-type counterparts and use of the evolved integrases to modify any sequence within the genome of a cell or subject.
A thickened pesticide formulation comprising entomopathogenic fungus spores or conidia is disclosed herein. The pesticide composition comprises the entomopathogenic fungus spores or conidia, a carrier oil, and a thickening oil, wherein the viscosity of the pesticide formulation is 1,500 to 2,000,000 cps. In some embodiments, the pesticide composition further comprises an abrasive agent and/or a lure for a target insect. Bait traps comprising the pesticide composition and methods of controlling an insect population in a designated geographical area are also described herein.
A01N 63/30 - Champignons microscopiquesSubstances produites par des champignons microscopiques ou obtenues à partir de ceux-ci
A01N 25/08 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles contenant des solides comme supports ou diluants
A01M 1/20 - Capture ou destruction des insectes par les poisons, les narcotiques ou le feu
A01N 65/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux contenant du matériel provenant d'algues, de lichens, de bryophytes, de champignons multicellulaires ou de plantes, ou leurs extraits
12.
EPIDERMAL MICROFLUIDIC DEVICES FOR THE CAPTURE, STORAGE, AND ANALYSIS OF SWEAT
An epidermal microfluidic device includes a rigid substrate defining microfluidic features (e.g., portions of channels, valves within channels, and/or portions of reservoirs) with gradient variation in height thereof. A rigid substrate of such a devices may permit flexure during use without breakage and without distortion of microfluidic features therein, such as by providing channel-defining, reduced-width linking portions extending outward between a central portion and reservoir portions, with the reservoir portions lacking direct coupling therebetween. An epidermal interface layer comprising a flexible material and defining a first aperture may be adhered to skin of a user, and multiple microfluidic devices may be sequentially provided over, and removed from, the epidermal interface layer to collect multiple independent, pristine sweat samples during an extended active collection period.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
Methods and apparatuses for continuous, large scale, commercially viable production of nanoforests. A roll-to-roll process passes a flexible substrate, including fibers and fabrics, through a furnace. Precursors are introduced in a growth zone in which a vertical or horizontal nanoforest of nanotubes or nanowires is grown on the substrate. Sensors and actuators with feedback control are provided for parameters such as substrate speed, substrate tension, furnace temperature, precursor flow rate, nanoforest thickness, and nanoforest. The furnace is preferably enclosed for environmental and safety purposes. The feed roll and take-up roll are disposed in housings can be attached to the furnace via airlocks, which enables rapid loading and unloading of the rolls using techniques well known in the industry while maintaining furnace conditions. The furnace can encompass flattening rollers and a second growth zone to enable manufacture of orthogonal nanoforests comprising a vertical nanoforest grown on a horizontal nanoforest.
C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
C23C 16/54 - Appareillage spécialement adapté pour le revêtement en continu
F27B 9/24 - Fours dans lesquels la charge est déplacée mécaniquement, p. ex. du type tunnel Fours similaires dans lesquels la charge se déplace par gravité caractérisés par le trajet de la charge pendant le traitementFours dans lesquels la charge est déplacée mécaniquement, p. ex. du type tunnel Fours similaires dans lesquels la charge se déplace par gravité caractérisés par le procédé de déplacement de la charge pendant le traitement la charge se déplaçant sur un trajet sensiblement rectiligne sur un transporteur
16.
MRI COMPATIBLE STEERABLE SURGICAL APPARATUS AND METHOD
A steerable surgical apparatus comprises a steerable surgical tubular needle, a needle manipulation apparatus with multiple actuators (permitting adjustment of needle rotation, translation, and bending), fiducial markers affixed to the needle manipulation apparatus, encoders configured to sense movements initiated by actuators, and a control unit. The needle manipulation apparatus is devoid of ferrous materials, and is configured to be placed and operated within an MRI machine bore. The control unit determines position and orientation for: (i) the needle manipulation apparatus relative to the MRI machine bore, such as by MRI imaging of the fiducial markers, and (ii) the needle inserted into a patient within the MRI machine bore, such as by kinematics utilizing signals of the encoders.
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
A61B 10/02 - Instruments pour prélever des échantillons cellulaires ou pour la biopsie
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A method for making transient plastic phase biochar from various biomass feedstocks includes receiving a biomass feedstock at a pyrolysis chamber, providing an inert gas or air environment to the pyrolysis chamber, and pyrolyzing the biomass feedstock in the pyrolysis chamber at a pressure above 1500 psi and a temperature range of 290 - 350 °C to generate the transient plastic phase biochar. The method may further include making a transient plastic phase biocarbon by grinding the transient plastic phase biochar into a powder, compressing the powder into a pellet, and devolatilized the pellet in an inert environment at atmospheric pressure at a temperature range of 300 - 1200 °C for 1 hour at a heating rate of 3-10 °C/min produce transient plastic phase biocarbon.
Embodiments of the invention are directed to inhibitors of FabK activity. Embodiments of the inventions are directed to compounds having a structure selected from the group consisting of an imidazole scaffold, a thiazole scaffold, a pyridine-thiazole scaffold, a benzothiazole scaffold, a benzimidazole scaffold, a benzoxazole scaffold and combinations thereof.
A61K 31/417 - Imidazole-alkylamines, p. ex. histamine, phentolamine
A61K 31/427 - Thiazoles non condensés et contenant d'autres hétérocycles
C07D 277/20 - Composés hétérocycliques contenant des cycles thiazole-1, 3 ou thiazole-1, 3 hydrogénés non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
The present disclosure relates generally to divalent immunogens comprising a scaffold and two antigens or epitopes thereof, multimers, compositions, and methods of using the same. Such divalent immunogens are useful, for example, for stimulating an immune response.
A61K 39/21 - Retroviridae, p. ex. virus de l'anémie infectieuse équine
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/62 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A61P 31/18 - Antiviraux pour le traitement des virus ARN du HIV
C12N 15/62 - Séquences d'ADN codant pour des protéines de fusion
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
Methods are provided of treating cardiac hypertrophy in a mammalian subject comprising administering to the subject an anti-hypertrophic effective amount of an ion channel TR-PV1 inhibitor. The methods include treatment of a symptom of cardiac hypertrophy in the subject comprises cardiac remodeling, cardiac fibrosis, apoptosis, hypertension, or heart failure
Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61P 31/14 - Antiviraux pour le traitement des virus ARN
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
Virulence factors from Burkholderia species are provided by this invention as are antibodies specifically binding the same and methods of using the virulence factors and antibodies in methods of immunizing and treating or attenuating a Burkholderia infection.
A compact structure for snapshot hyperspectral imaging may include an image slicer, an integral field unit, an integral field spectrograph, and multiplexed integral field spectrograph. The image slicer includes a first section having a first plurality of mirrors, each mirror of the first plurality of mirrors having a predetermined tilt in a longitudinal direction, a second section having a second plurality of mirrors, each mirror of the second plurality of mirrors having a predetermined tilt in the longitudinal direction, and a ridge extending laterally between the first section and the second, the first section being at a first angle relative to the ridge and the second section being at a second angle opposite to the first angle relative to the ridge. The integral field unit source includes a four mirror design including an image slicer. The integral field spectrograph includes an array of spectrographs and an image slicer.
A system for mechanical attachment includes a first structure including a first body that is configured for a supporting surface and is connected to a member that extends from the first body. The system further includes a second structure including a second body that is also configured for a supporting surface with a compliant member that extends from the second body. The second structure is configured to form a connection with the first structure by deformation of at least a portion of the compliant member relative to the first structure.
B81B 7/04 - Réseaux ou matrices de dispositifs à microstructure semblables
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
B81C 3/00 - Assemblage de dispositifs ou de systèmes à partir de composants qui ont reçu un traitement individuel
H01L 23/48 - Dispositions pour conduire le courant électrique vers le ou hors du corps à l'état solide pendant son fonctionnement, p. ex. fils de connexion ou bornes
25.
HIGH ENTROPY OXIDES AND METHODS OF SYNTHESIS AND USE THEREOF
The present invention provides compositions and nanomaterials comprising a metal based high entropy oxide comprising at least five metals and their oxides distributed in a crystal structure, with high configurational entropy, a high number of oxygen vacancies and active catalytic sites. The present invention also relates to methods of synthesis of said compositions and nanomaterials using microwave irradiation and methods of use of said compositions and nanomaterials in analyte sensing as nanozymes, electrochemical sensors, and colorimetric sensors.
C22C 29/12 - Alliages à base de carbures, oxydes, borures, nitrures ou siliciures, p. ex. cermets, ou d'autres composés métalliques, p. ex. oxynitrures, sulfures à base d'oxydes
C22C 30/02 - Alliages contenant moins de 50% en poids de chaque constituant contenant du cuivre
B22F 9/24 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par un procédé chimique avec réduction de mélanges métalliques à partir de mélanges métalliques liquides, p. ex. de solutions
Methods and apparatuses for continuous, large scale, commercially viable production of nanoforests. A roll-to-roll process passes a flexible substrate, including fibers and fabrics, through a furnace. Precursors are introduced in a growth zone in which a vertical or horizontal nanoforest of nanotubes or nanowires is grown on the substrate. Sensors and actuators with feedback control are provided for parameters such as substrate speed, substrate tension, furnace temperature, precursor flow rate, nanoforest thickness, and nanoforest. The furnace is preferably enclosed for environmental and safety purposes. The feed roll and take-up roll are disposed in housings can be attached to the furnace via airlocks, which enables rapid loading and unloading of the rolls using techniques well known in the industry while maintaining furnace conditions. The furnace can encompass flattening rollers and a second growth zone to enable manufacture of orthogonal nanoforests comprising a vertical nanoforest grown on a horizontal nanoforest.
C23C 16/455 - Revêtement chimique par décomposition de composés gazeux, ne laissant pas de produits de réaction du matériau de la surface dans le revêtement, c.-à-d. procédés de dépôt chimique en phase vapeur [CVD] caractérisé par le procédé de revêtement caractérisé par le procédé utilisé pour introduire des gaz dans la chambre de réaction ou pour modifier les écoulements de gaz dans la chambre de réaction
C23C 16/54 - Appareillage spécialement adapté pour le revêtement en continu
F27B 9/24 - Fours dans lesquels la charge est déplacée mécaniquement, p. ex. du type tunnel Fours similaires dans lesquels la charge se déplace par gravité caractérisés par le trajet de la charge pendant le traitementFours dans lesquels la charge est déplacée mécaniquement, p. ex. du type tunnel Fours similaires dans lesquels la charge se déplace par gravité caractérisés par le procédé de déplacement de la charge pendant le traitement la charge se déplaçant sur un trajet sensiblement rectiligne sur un transporteur
27.
TELMISARTAN NANOSUSPENSION FOR THERAPY OF RESPIRATORY INFECTIONS AND METHODS OF MAKING AND USING SAME
A method of inhibiting viral replication of a virus in an individual comprising administering an effective amount of a drug nanosuspension combined with a surfactant, wherein the drug nanosuspension combined with the surfactant is delivered to the individual's lungs. Preferably, the drug is a nanosuspension delivered to the individual's lungs through inhalation.
A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light.
G01J 3/26 - Production du spectreMonochromateurs en utilisant une réflexion multiple, p. ex. interféromètre de Fabry-Perot, filtre à interférences variables
G01J 3/14 - Production du spectreMonochromateurs en utilisant des éléments réfringents, p. ex. prisme
G01J 3/453 - Spectrométrie par interférence par corrélation des amplitudes
30.
SELF-CHARGING DROPLET CAPACITOR FOR HARVESTING LOW-LEVEL AMBIENT ENERGY
A self-charging droplet capacitor for harvesting low-level ambient energy is provided. The capacitor includes a conductive liquid droplet, which is placed on a heterogeneous and hydrophobic surface of dielectric materials coated onto a conductive substrate. The substrate and the droplet, along with the dielectric materials in between, form a parallel-plate type capacitor. The droplet is free to move on the surface, and thus, provides a position-dependent variation of capacitance. The surface consists of two regions, each with a different material and thickness. The different strengths of solid-water contact electrification of the two materials give rise to a self-charging mechanism. The variation in thickness allows for the capacitance change required for energy harvesting.
In some examples, anthropometric parameters of a subject are ascertained from radiographic image data. Radiograph image data is transformed to a representation of a lower dimensionality than the dimensionality of the image data by an machine learning processor. The representation of the radiograph image data is mapped to anthropometric parameters, directly or first to an intermediate three-dimensional optical image of the subject, and then from the intermediate three-dimensional optical image to anthropometric parameters.
In some embodiments, a bioimpedance measurement apparatus includes a set of electrodes configured to be placed on respective skin portions of a subject; a temperature sensor probe configured to be placed on a respective skin portion of the subject; a moisture sensor probe configured to be placed on a respective skin portion of the subject; and an electronic module configured to determine an impedance between at least two of the plurality of electrodes, receive from the temperature probe a temperature signal and determine from the temperature signal a temperature of the skin portion the temperature sensor probe is placed on, receive from the moisture sensor probe a moisture signal and determine a moisture level of the skin portion the moisture sensor probe is placed on, and determine a bioimpedance of the subject based at least in part on the determined impedance, temperature, and moisture level.
A61B 5/0537 - Mesure de la composition du corps par impédance, p. ex. de l’hydratation des tissus ou de la teneur en graisses
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 5/01 - Mesure de la température de parties du corps
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
33.
TRANSPOSABLE MOBILE ELEMENTS WITH ENHANCED GENOMIC SITE SELECTION
A reinforcement for increasing the strength and toughness and other properties in both transverse and in-piano directions for a composite material, and methods of manufacture therefor. The reinforcement has a layer of a nanoforest of vertical nanotubes or nanowires and a layer of horizontal nanotubes or nanowires. The reinforcement can be made by rolling a vertical nanoforest to produce a collapsed layer of horizontal nanofubes or nanowires, then growing a vertical nanoforest on the collapsed layer. The reinforcement can be grown directly on fibers which are used to reinforce the composite material, or alternatively Interleaved with layers of those fibers before the composite part is cured. The reinforcement and manufacturing method are compatible with almost any composite material in any shape, including epoxy, polymer, or ceramic matrix composites, or any manufacturing method, including prepreg, wet-layup and matrix film stacking. The present invention reduces scrap, rework, and repair hours for composites manufacturing.
B32B 5/12 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments caractérisés par la disposition relative des fibres ou filaments des couches adjacentes
B32B 5/26 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par la présence de plusieurs couches qui comportent des fibres, filaments, grains ou poudre, ou qui sont sous forme de mousse ou essentiellement poreuses une des couches étant fibreuse ou filamenteuse un autre couche également étant fibreuse ou filamenteuse
B32B 1/00 - Produits stratifiés ayant une forme non plane
B32B 7/02 - Propriétés physiques, chimiques ou physicochimiques
An epidermal microfluidic device includes a rigid substrate defining microfluidic features (e.g., portions of channels, valves within channels, and/or portions of reservoirs) with gradient variation in height thereof. A rigid substrate of such a devices may permit flexure during use without breakage and without distortion of microfluidic features therein, such as by providing channel-defining, reduced-width linking portions extending outward between a central portion and reservoir portions, with the reservoir portions lacking direct coupling therebetween. An epidermal interface layer comprising a flexible material and defining a first aperture may be adhered to skin of a user, and multiple microfluidic devices may be sequentially provided over, and removed from, the epidermal interface layer to collect multiple independent, pristine sweat samples during an extended active collection period.
A61B 10/00 - Instruments pour le prélèvement d'échantillons corporels à des fins de diagnostic Autres procédés ou instruments pour le diagnostic, p. ex. pour le diagnostic de vaccination ou la détermination du sexe ou de la période d'ovulationInstruments pour gratter la gorge
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
B01L 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
36.
Compositions and methods of manufacturing trivalent filovirus vaccines
Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61P 31/14 - Antiviraux pour le traitement des virus ARN
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
37.
SYSTEMS AND METHODS FOR AN AUTOMATIC IDENTIFICATION SYSTEM (AIS) HEADS UP DISPLAY
A system for sensing maritime position and visualization includes an imaging device configured to capture an image including a vessel, a receiver configured to receive a first geospatial position of a user device and/or a compass heading of the user device, an Automatic Identification System (AIS) receiver configured to receive an AIS message, a processor, and a memory. The AIS message includes a second geospatial position of the vessel. The memory includes instructions, which, when executed by the processor, cause the system to capture an image of the vessel, receive a position and a heading of the user device, receive the AIS message, match the vessel in the captured image with the vessel identifier and the second geospatial position of the vessel of the AIS message, and generate an augmented reality marker based on the vessel identifier and the second geospatial position of the vessel of the AIS message.
B63B 43/18 - Amélioration de la sécurité des navires, p. ex. contrôle des avaries, non prévue ailleurs par prévention des abordagesAmélioration de la sécurité des navires, p. ex. contrôle des avaries, non prévue ailleurs par réduction des dommages dus aux abordages
G01C 21/00 - NavigationInstruments de navigation non prévus dans les groupes
38.
Method for Preparing Heteroleptic Triarylbismuthanes and Compounds Produced by the Same
A method for controlling dismutation in the synthesis of a heteroleptic triarylbismuthane is provided as are compounds produced by such a method and use of the same to inhibit the replication of microorganisms.
The present disclosure provides pharmaceutical compositions comprising aryl sulfonamide Stat3 small molecule inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use for treating cancer.
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 205/04 - Composés hétérocycliques comportant des cycles à quatre chaînons ne contenant qu'un atome d'azote comme unique hétéro-atome du cycle non condensés avec d'autres cycles ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07C 317/36 - SulfonesSulfoxydes ayant des groupes sulfone ou sulfoxyde et des atomes d'azote, ne faisant pas partie de groupes nitro ou nitroso, liés au même squelette carboné avec des groupes sulfone ou sulfoxyde liés à des atomes de carbone de cycles aromatiques à six chaînons du squelette carboné ayant des groupes sulfone ou sulfoxyde et des groupes amino liés à des atomes de carbone de cycles aromatiques à six chaînons faisant partie du même cycle non condensé ou d'un système cyclique condensé contenant ce cycle avec les atomes d'azote de groupes amino liés à des atomes d'hydrogène ou à des atomes de carbone
C07D 237/32 - Phtalazines avec des atomes d'oxygène liés directement aux atomes de carbone du cycle contenant l'azote
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
Methods described herein, in some embodiments, permit extraction of particle structural and/or surface charge data from gradient induced particle motion in channels. In one aspect, a method of manipulating particle motion comprises introducing a fluid into a channel, the fluid comprising particles, and driving particle accumulation to a preselected location in the channel by setting advective velocity of the fluid to offset diffusiophoretic mobility of the particles at the preselected location.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
41.
UNIVERSITY OF HAWAII MALAMALAMA UA MAU KE EA O KA AINA I KA PONO 1907
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educating at universities or colleges; Educational services, namely, providing courses of instruction at the college, university, undergraduate, graduate level and distribution of course material in connection therewith; Organizing and conducting college sport competitions and athletic events; Providing facilities for recreational activities, namely, plays, musical and theatrical performances, swimming, diving, water polo, track and field, tennis, baseball, football, weight training; Providing courses of instruction at the college, university, undergraduate, post-graduate level; Teaching, training, tutoring and courses of instruction at the undergraduate, graduate and post-graduate level
42.
UNIVERSITY OF HAWAII MALAMALAMA UA MAU KE EA O KA AINA I KA PONO 1907
Pencils; Pens; Book covers; Printed educational publications, namely, magazines, journals, brochures, and other printed materials in the fields of programs and activities associated with the University of Hawaii; Writing paper; Office binders; Paper folders; Paper notebooks; Printed notepads; Three-ring binders
Disclosed herein is a system and method for energy generation from salinity gradients using asymmetrically porous electrodes. In certain embodiments, an energy generation system includes at least one pair of asymmetrically porous electrodes positioned within a chamber in selective fluidic communication with a freshwater source (e.g., a river) and a saltwater source (e.g., an ocean). Asymmetry between a first average percent volume per unit pore-width of a first electrode and a second average percent volume per unit pore-width of a second electrode creates differing interfacial potentials between the first electrode and the second electrode when such electrodes are immersed in freshwater and saltwater. By cyclically immersing the electrodes in freshwater and saltwater, energy is harvested from Gibbs free energy from mixing saltwater and freshwater. Such a system does not require a membrane or an external charge source. Methods of generating energy using asymmetrically porous electrodes are also provided.
H01M 8/22 - Éléments à combustible dans lesquels le combustible est à base de matériaux comprenant du carbone, de l'oxygène ou de l'hydrogène et d'autres élémentsÉléments à combustible dans lesquels le combustible est à base de matériaux comprenant uniquement des éléments autres que le carbone, l'oxygène ou l'hydrogène
46.
STEERABLE SURGICAL DEVICES, AND METHODS FOR THEIR USE AND TRACKING
A steerable surgical device includes tubular body members and at least one moveable joint, with a moveable tray member arranged to permit tissue extraction and a retractable tip member for removal of a sample while a remainder of the surgical device remains in the tissue. A method utilizes sensed SMA electrical properties and sensed compressive force to determine joint deflection that is used with a joint deflection model to map tip position in tissue. Another method for determining position of a tip of a steerable instrument within tissue utilizes transverse ultrasound probe images and image processing together with saved and predicted tip information. A method for sequentially removing a plurality of samples from tissue utilizes a steerable surgical device, without requiring complete removal of the device from the tissue
A method of making a ceramic matrix composite (CMC) part such as armor, in which a mixture, including a preceramic polymer, particles such as ceramic microparticles and/or nanoparticles, and organic compounds such as a surfactant and a solvent, are mixed to form a paste and printed or molded. The part is then cured and densified by polymer infiltration and pyrolysis (PIP) using the preceramic polymer with a varying amount and size of ceramic particles and different temperatures in some of the cycles. The CMC can contain silicon carbide, boron carbide, boron suboxide, alumina, or any other ceramic. The process is compatible with sacrificial materials, enabling the creation of parts with hollow portions or overhangs. The mixture preferably has a high loading of particles, for example between 70 wt % and 90 wt % of the mixture, in order to minimize shrinkage. Curing and pyrolyzing the part can be performed by microwaving. Two such CMC parts can be joined together by using the paste, having the same or a different concentration of particles, as an adhesive.
C04B 35/563 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de carbures à base de carbure de bore
C04B 35/626 - Préparation ou traitement des poudres individuellement ou par fournées
C04B 35/565 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base de non oxydes à base de carbures à base de carbure de silicium
F41H 5/04 - Structure des plaques composées de plus d'une couche
Systems and methods are described for the global, rapid, and automatic detection of wildfire activity. Such systems and methods may also classify wildfires based on a new severity classification scheme. Wildfire activity may be tracked as wildfires migrate, grow, and combine. Additionally, because satellite systems currently collect over 4 million fire observations per year, a filtering mechanism is introduced to remove benign anthropogenic fires. To classify wildfire severity for generating alerts, the present disclosure also provides a logarithmic severity classification system based on 24-hour cumulative Fire Radiative Power (FRP).
A62C 3/02 - Prévention, limitation ou extinction des incendies spécialement adaptées pour des objets ou des endroits particuliers pour des zones d'embrasement, p. ex. des incendies de forêts, des feux souterrains
G08B 17/12 - Déclenchement par la présence de rayonnement ou de particules, p. ex. de rayonnement infrarouge ou d'ions
G08B 21/10 - Alarmes pour assurer la sécurité des personnes réagissant aux événements désastreux, p. ex. les tornades ou les tremblements de terre
G08B 17/00 - Alarmes d'incendieAlarmes réagissant à une explosion
49.
ANTIBODY/ADJUVANT COMPOSITIONS AND METHODS OF IMMUNE RESPONSE GENERATION AGAINST CORONAVIRUSES
Recombinant vaccine compositions combined with a specified adjuvant to deliver a robust immune response against coronaviruses for inducing protective immunity to a coronavirus comprising providing a stable immunogenic composition capable of eliciting a robust and durable immune response to the coronavirus, wherein the composition comprises a protein subunit comprising a recombinant protein specific to the coronavirus and at least one adjuvant.
Methods and apparatuses for continuous, large scale, commercially viable production of nanoforests. A roll-to-roll process passes a flexible substrate, including fibers and fabrics, through a furnace. Precursors are introduced in a growth zone in which a vertical or horizontal nanoforest of nanotubes or nanowires is grown on the substrate. Sensors and actuators with feedback control are provided for parameters such as substrate speed, substrate tension, furnace temperature, precursor flow rate, nanoforest thickness, and nanoforest. The furnace is preferably enclosed for environmental and safety purposes. The feed roll and take-up roll are disposed in housings can be attached to the furnace via airlocks, which enables rapid loading and unloading of the rolls using techniques well known in the industry while maintaining furnace conditions. The furnace can encompass flattening rollers and a second growth zone to enable manufacture of orthogonal nanoforests comprising a vertical nanoforest grown on a horizontal nanoforest.
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Arranging and conducting athletic competitions; Educational services, namely, providing internships and apprenticeships in the field of intercollegiate sports; Entertainment services, namely, organizing and conducting an array of athletic events rendered live and recorded for the purpose of distribution through broadcast media; Organizing community festivals featuring primarily coach, staff, and student-athlete events and also providing fellowship, community service, and food and beverages; Organizing and conducting college athletic events; Organizing and conducting college sport competitions and athletic events; Providing online interviews featuring student-athletes, coaches, and/or staff in the field of sports for entertainment purposes; Providing collegiate athletic and sporting events
Compositions and methods for preparing and identifying aptamers and aptamer-protein conjugates are provided. The use of a nucleotide analog functionalized with an amine-reactive cross-linker facilitates covalent cross-linking of the aptamer to a protein, in particular site-specific cross-linking to the Fc domain of an antibody.
C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
C07H 19/10 - Radicaux pyrimidine avec le radical saccharide estérifié par des acides phosphoriques ou polyphosphoriques
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
C12N 15/10 - Procédés pour l'isolement, la préparation ou la purification d'ADN ou d'ARN
Pens; Stickers; Decals; Magnetic decals; Pencil cases; Pencils; Printed notebooks; Printed educational publications, namely, magazines, journals, brochures, and other printed materials, namely posters, flyers, handbills, and handouts in the fields of programs and activities associated with the University of Hawaii
Footwear; Athletic apparel, namely, shirts, pants, jackets, footwear, hats and caps, athletic uniforms; Children's headwear; Clothing, namely, tshirts, tank tops, jackets, shorts, pants, polo shirts, neck ties, long or short sleeve shirts, jogging suits, sweatpants, sweatshirts, scarves, socks, and button front aloha shirts; Infant and toddler one piece clothing; Headwear, namely, hats, caps, visors; One piece garment for infants and toddlers; Shirts for infants, babies, toddlers and children
56.
SELF-CHARGING DROPLET CAPACITOR FOR HARVESTING LOW-LEVEL AMBIENT ENERGY
A self-charging droplet capacitor for harvesting low-level ambient energy is provided. The capacitor includes a conductive liquid droplet, which is placed on a heterogeneous and hydrophobic surface of dielectric materials coated onto a conductive substrate. The substrate and the droplet, along with the dielectric materials in between, form a parallel-plate type capacitor. The droplet is free to move on the surface, and thus, provides a position-dependent variation of capacitance. The surface consists of two regions, each with a different material and thickness. The different strengths of solid-water contact electrification of the two materials give rise to a self-charging mechanism. The variation in thickness allows for the capacitance change required for energy harvesting.
H02N 1/08 - Générateurs à influence avec porteur de charge conducteur, c.-à-d. machines à capacité
H02N 3/00 - Générateurs dans lesquels l'énergie thermique ou cinétique est convertie en énergie électrique par ionisation d'un fluide et enlèvement de sa charge
H02N 11/00 - Générateurs ou moteurs non prévus ailleursMouvements dits perpétuels obtenus par des moyens électriques ou magnétiques
57.
ORTHOGONAL CARBON-NANOTUBE-BASED NANOFOREST FOR HIGH-PERFORMANCE HIERARCHICAL MULTIFUNCTIONAL NANOCOMPOSITES
A reinforcement for increasing the strength and toughness and other properties in both transverse and in-piano directions for a composite material, and methods of manufacture therefor. The reinforcement has a layer of a nanoforost of vertical nanotubes or nanowires and a layer of horizontal nanotubes or nanowires. The reinforcement can be made by rolling a vertical nanoforest to produce a collapsed layer of horizontal nanofubes or nanowires, then growing a vertical nanoforest on the collapsed layer. The reinforcement can be grown directly on fibers which are used to reinforce the composite material, or alternatively Interleaved with layers of those fibers before the composite part is cured. The reinforcement and manufacturing method are compatible with almost any composite material in any shape, including epoxy, polymer, or ceramic matrix composites, or any manufacturing method, including prepreg, wet-layup and matrix film stacking. The present invention reduces scrap, rework, and repair hours for composites manufacturing.
B32B 5/10 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments caractérisés par une couche fibreuse renforcée par des filaments
B32B 5/12 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments caractérisés par la disposition relative des fibres ou filaments des couches adjacentes
An antibody targeting Galectin-9 is provided as are methods of using the same treatment of chronic immune conditions such as infections, inflammatory diseases and cancer, in particular malignant mesothelioma.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
In one embodiment, a device configured to monitor a power grid determines whether a configuration of a field-programmable gate array (FPGA) of the device requires updating, the configuration comprising one or more digital signal processor (DSP) applications (apps), and updates the configuration when required. The device measures grid metrics of a power grid (e.g., voltage and current), and also determines GPS-based time for synchronizing zero crossing events of the grid metrics to the GPS-based time. According to the one or more DSP apps, the grid metrics can be processed by the device, and then the processed grid metrics and synchronized zero crossing events can be shared. In one specific embodiment, processing the grid metrics according to the one or more DSP apps comprises estimating an impedance of one or more individual circuit segments based on measured grid metric response to a transient event (e.g., active or passive events).
H02J 13/00 - Circuits pour pourvoir à l'indication à distance des conditions d'un réseau, p. ex. un enregistrement instantané des conditions d'ouverture ou de fermeture de chaque sectionneur du réseauCircuits pour pourvoir à la commande à distance des moyens de commutation dans un réseau de distribution d'énergie, p. ex. mise en ou hors circuit de consommateurs de courant par l'utilisation de signaux d'impulsion codés transmis par le réseau
H02J 9/06 - Circuits pour alimentation de puissance de secours ou de réserve, p. ex. pour éclairage de secours dans lesquels le système de distribution est déconnecté de la source normale et connecté à une source de réserve avec commutation automatique
H02J 3/38 - Dispositions pour l’alimentation en parallèle d’un seul réseau, par plusieurs générateurs, convertisseurs ou transformateurs
G05B 19/042 - Commande à programme autre que la commande numérique, c.-à-d. dans des automatismes à séquence ou dans des automates à logique utilisant des processeurs numériques
Embodiments of the present disclosure relate generally to the analysis of broad metabolic changes associated with neurological disorders. In particular, the present disclosure provides materials and methods relating to the use of metabolomics as a biochemical approach to identify peripheral metabolic changes and corresponding metabolic biomarkers of neurological disorders. Embodiments of the present disclosure include the use of bile acids and their derivatives as metabolic biomarkers to aid in the determination of whether a subject suffers from, or is at risk of developing, a neurological disorder, such as Alzheimer's Disease (AD).
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C07J 1/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, non substitués en position 17bêta par un atome de carbone, p. ex. œstrane, androstane
61.
Point-of-care electroflotation of dispersed, low tolerance pathogens
The present invention relates to delivering sample preparation technologies to enhance the performance of point-of-care agricultural diagnostics by improving the capacity to detect trace contaminations of pathogenic organisms along the entire food supply chain including pre- and post-harvest processing and distribution. Sample preparation is crucial for adequate test performance of downstream diagnostics like LAMP and supports sensitive detection of bacterial contaminates. This invention increases the speed and scale of routine pathogen surveillance and the efficacy of management response and mitigation of foodborne disease outbreaks.
B03D 1/02 - Procédés de flottation par formation d'écume
C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
C02F 1/465 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse par électroflottation
C02F 1/52 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par floculation ou précipitation d'impuretés en suspension
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
C12Q 1/6806 - Préparation d’acides nucléiques pour analyse, p. ex. pour test de réaction en chaîne par polymérase [PCR]
C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
A spatial Fourier transform spectrometer is disclosed. The Fourier transform spectrometer includes a Fabry-Perot interferometer with first and second optical surfaces. The gap between the first and second optical surfaces spatially varies in a direction that is orthogonal to the optical axis of the Fourier transform spectrometer. The Fabry-Perot interferometer creates an interference pattern from input light. An image of the interference pattern is captured by a detector, which is communicatively coupled to a processor. The processor is configured to process the interference pattern image to determine information about the spectral content of the input light.
G01J 3/26 - Production du spectreMonochromateurs en utilisant une réflexion multiple, p. ex. interféromètre de Fabry-Perot, filtre à interférences variables
G01J 3/453 - Spectrométrie par interférence par corrélation des amplitudes
G01J 3/14 - Production du spectreMonochromateurs en utilisant des éléments réfringents, p. ex. prisme
63.
METHOD FOR PREPARING HETEROLEPTIC TRIARYLBISMUTHANES AND COMPOUNDS PRODUCED BY THE SAME
A method for controlling dismutation in the synthesis of a heteroleptic triarylbismuthane is provided as are compounds produced by such a method and use of the same to inhibit the replication of microorganisms.
In one embodiment, a ground-based sky imaging and irradiance measurement and prediction computing device: obtains, from an omnidirectional ultra-panoramic camera located at a ground-based mounting location, an image having a view of an entire sky located above the camera and a horizon-to-horizon view of ground and ground-based objects surrounding the camera; calibrates a relationship between locations of pixels of the image and real-world three-dimensional coordinates based on intrinsic/extrinsic properties of the camera; identifies image pixels that contain clouds; georegisters, the clouds to real-world three-dimensional coordinates; and estimates, cloud attenuation levels. A solar irradiance map can then be generated based on the georegistration of the clouds, sun position, and estimated attenuation level of the clouds, where the solar irradiance map indicates an estimation of solar irradiance to reach an area of ground surrounding the camera.
Systems and methods are described for performing logical filtering of hazard alerts by an area of geography the hazard is expected to impact and issuing alerts based on that area. Based on a geographical location, a hazard type, and a hazard severity, one or more geographic areas the hazard is expected to impact may be determined. One or more automated alerts may be issued to alert users in those areas that could be affected by the hazard.
G08B 25/00 - Systèmes d'alarme dans lesquels l'emplacement du lieu où existe la condition déclenchant l'alarme est signalé à une station centrale, p. ex. systèmes télégraphiques d'incendie ou de police
G08B 21/10 - Alarmes pour assurer la sécurité des personnes réagissant aux événements désastreux, p. ex. les tornades ou les tremblements de terre
H04W 4/90 - Services pour gérer les situations d’urgence ou dangereuses, p. ex. systèmes d’alerte aux séismes et aux tsunamis
H04W 76/50 - Gestion de la connexion pour les connexions d'urgence
H04W 4/021 - Services concernant des domaines particuliers, p. ex. services de points d’intérêt, services sur place ou géorepères
66.
ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS
The present disclosure provides pharmaceutical compositions comprising aryl sulfonamide Stat3 small molecule inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use for treating cancer.
C07C 311/18 - Sulfonamides ayant des atomes de soufre de groupes sulfonamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes sulfonamide lié à des atomes d'hydrogène ou à un atome de carbone acyclique à un atome de carbone acyclique d'un radical hydrocarboné substitué par des atomes d'azote ne faisant pas partie de groupes nitro ou nitroso
C07C 311/16 - Sulfonamides ayant des atomes de soufre de groupes sulfonamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes sulfonamide lié à des atomes d'hydrogène ou à un atome de carbone acyclique
Disclosed herein is a system and method for energy generation from salinity gradients using asymmetrically porous electrodes. In certain embodiments, an energy generation system includes at least one pair of asymmetrically porous electrodes positioned within a chamber in selective fluidic communication with a freshwater source (e.g., a river) and a saltwater source (e.g., an ocean). Asymmetry between a first average percent volume per unit pore-width of a first electrode and a second average percent volume per unit pore-width of a second electrode creates differing interfacial potentials between the first electrode and the second electrode when such electrodes are immersed in freshwater and saltwater. By cyclically immersing the electrodes in freshwater and saltwater, energy is harvested from Gibbs free energy from mixing saltwater and freshwater. Such a system does not require a membrane or an external charge source. Methods of generating energy using asymmetrically porous electrodes are also provided.
Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61P 31/14 - Antiviraux pour le traitement des virus ARN
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
69.
COMPOSITIONS AND METHODS OF MANUFACTURING TRIVALENT FILOVIRUS VACCINES
Disclosed is a stable immunogenic composition capable of eliciting a robust and durable immune response, comprising at least one antigen consisting of a filovirus glycoprotein and at least one nano-emulsion adjuvant which are co-lyophilized and can be reconstituted immediately prior to use. Also disclosed is a vaccine composition comprising at least two antigens, wherein each antigen is specific to a different genus of filovirus and which also comprises at least one nano-emulsion adjuvant.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
70.
GSK-3β inhibitors and use thereof in methods of treatment
Isoorientin analogues and related compounds that inhibit glycogen synthase kinase-3β activity are provided as are methods of using these compounds in the treatment of cognitive, neurodegenerative or neurological diseases or conditions, as well as cancer, obesity, diabetes, inflammatory or autoimmune disease, cardiovascular disorder, metabolic syndrome X, hair loss, severe acute respiratory syndrome coronavirus, cocaine addiction, dental caries, bone loss and glaucoma.
C07C 49/835 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes hydroxyle avec insaturation autre que celle d'un cycle aromatique
Methods described herein, in some embodiments, permit extraction of particle structural and/or surface charge data from gradient induced particle motion in channels. In one aspect, a method of manipulating particle motion comprises introducing a fluid into a channel, the fluid comprising particles, and driving particle accumulation to a preselected location in the channel by setting advective velocity of the fluid to offset diffusiophoretic mobility of the particles at the preselected location.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
72.
Activated magnesium boride materials for hydrogen storage
Some embodiments described herein provide for methods for synthesizing magnesium borohydride from hydrogenation of magnesium boride at moderate temperature and pressure in the presence of a modifier. The modifier may be in form of hydrides, liquid hydrogen carriers, ammonia borane, metallic species, croconate anion based materials, ethers, amines or imines, metal carbides, borides, graphene, arenes, magnesium, aluminum, calcium or ionic liquids. Some embodiments provide for charging magnesium boride in presence of a modifier at high pressure hydrogen while simultaneously heating the material. The modification in some instances may lead to an improved magnesium boride product with enhanced properties for application in other hydrogen storage systems.
Systems and methods are described for the global, rapid, and automatic detection of wildfire activity. Such systems and methods may also classify wildfires based on a new severity classification scheme. Wildfire activity may be tracked as wildfires migrate, grow, and combine. Additionally, because satellite systems currently collect over 4 million fire observations per year, a filtering mechanism is introduced to remove benign anthropogenic fires. To classify wildfire severity for generating alerts, the present disclosure also provides a logarithmic severity classification system based on 24-hour cumulative Fire Radiative Power (FRP).
G08B 17/12 - Déclenchement par la présence de rayonnement ou de particules, p. ex. de rayonnement infrarouge ou d'ions
G08B 17/00 - Alarmes d'incendieAlarmes réagissant à une explosion
A62C 3/02 - Prévention, limitation ou extinction des incendies spécialement adaptées pour des objets ou des endroits particuliers pour des zones d'embrasement, p. ex. des incendies de forêts, des feux souterrains
74.
Environmental sensor array for fuel cell air filtration systems
In one embodiment, an environmental sensor array monitors pre-filter airflow to a fuel cell with an air filter, and senses amounts of filter exposure of air contaminants in the monitored pre-filter airflow. The environmental sensor array may then correlate the sensed amounts of filter exposure over time to a long-term adsorption limit of the air contaminants for the air filter, determining a lifetime usage level of the air filter. Accordingly, the environmental sensor array may provide an indication of the lifetime usage level of the air filter. In another embodiment, the environmental sensor array may also monitor post-filter airflow to the fuel cell, and senses instantaneous levels of post-filter air contaminants. In response to the instantaneous level of any particular air contaminant of the post-filter air contaminants being above a respective threshold level, the environmental sensor array may protect the operation of the fuel cell (e.g., de-rate, shut down, etc.).
H01M 8/04955 - Extinction ou arrêt des éléments à combustible
H01M 8/04992 - Procédés de commande des éléments à combustible ou des systèmes d’éléments à combustible caractérisés par la mise en œuvre d’algorithmes mathématiques ou de calcul, p. ex. les boucles de commande de rétroaction, la logique floue, les réseaux neuronaux ou l’intelligence artificielle
75.
COMPOSITIONS AND METHODS FOR THE SYNTHESIS AND IDENTIFICATION OF COVALENT APTAMERS
Compositions and methods for preparing and identifying aptamers and aptamer-protein conjugates are provided. The use of a nucleotide analog functionalized with an amine- reactive cross-linker facilitates covalent cross-linking of the aptamer to a protein, in particular site-specific cross-linking to the Fc domain of an antibody.
C12Q 1/6811 - Méthodes de sélection pour la production ou l’élaboration d’oligonucléotides spécifiques cibles ou de molécules de liaison
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
Leucadendron plant named ‘Hawaii Sunrise’ that is distinguished by a very compact bushy plant habit with densely packed foliage and many current-season branches which are bright red in color and which bear terminal inflorescences whose bracts are yellow in color with contrasting bright orange-red coloration to their apex and margin. ‘Hawaii Sunrise’ bears only male flowers which are bright yellow in color.
A hybrid method and system for data encryption significantly reduces the computational cost of encryption and reduces the cost of the processors needed to perform encryption and decryption.
H04L 9/00 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité
G06N 3/04 - Architecture, p. ex. topologie d'interconnexion
H04L 9/06 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité l'appareil de chiffrement utilisant des registres à décalage ou des mémoires pour le codage par blocs, p. ex. système DES
H04L 9/32 - Dispositions pour les communications secrètes ou protégéesProtocoles réseaux de sécurité comprenant des moyens pour vérifier l'identité ou l'autorisation d'un utilisateur du système
78.
Autonomous system and method for planning, tracking, and controlling the operation of steerable surgical devices
An autonomous system and method for controlling the operation of a steerable surgical device includes multiple surgical device actuation elements, an imaging apparatus (e.g., ultrasound) arranged external to a mammalian body, and at least one processor. The processor(s) is/are configured to generate a transit path between an insertion point and a target point, control the surgical device actuation elements to advance the steerable surgical device along one or more segments of the transit path, identify deviation of position relative to the transit path utilizing signals from the imaging apparatus and generate an updated transit path, and control the surgical device actuation elements to advance the steerable surgical device along at least one segment of the updated transit path. Transit of the steerable surgical device between the insertion point and the target point may be controlled without human intervention.
A61B 17/00 - Instruments, dispositifs ou procédés chirurgicaux
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 34/32 - Robots chirurgicaux opérant de façon autonome
An antibody targeting Galectin-9 is provided as are methods of using the same treatment of chronic immune conditions such as infections, inflammatory diseases and cancer, in particular malignant mesothelioma.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C07K 16/30 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire provenant de cellules de tumeurs
80.
POINT-OF-CARE ELECTROFLOTATION OF DISPERSED, LOW TOLERANCE PATHOGENS
The present invention relates to delivering sample preparation technologies to enhance the performance of point-of-care agricultural diagnostics by improving the capacity to detect trace contaminations of pathogenic organisms along the entire food supply chain including pre- and post-harvest processing and distribution. Sample preparation is crucial for adequate test performance of downstream diagnostics like LAMP and supports sensitive detection of bacterial contaminates. This invention increases the speed and scale of routine pathogen surveillance and the efficacy of management response and mitigation of foodborne disease outbreaks.
The present disclosure provides pharmaceutical compositions comprising 2-arylsulfonamido-N-arylacetamide derivatized Stat3 inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use.
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 205/04 - Composés hétérocycliques comportant des cycles à quatre chaînons ne contenant qu'un atome d'azote comme unique hétéro-atome du cycle non condensés avec d'autres cycles ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
82.
Steerable surgical devices with shape memory alloy wires
A steerable surgical device includes a flexible joint positioned between first and second tubular elements, with multiple shape memory alloy wire elements extending across or through the joint being circumferentially spaced relative to one another and independently actuatable to effectuate pivotal movement between the first and second tubular elements (e.g., along at least two or at least three nonparallel planes) to provide enhanced maneuverability relative to single degree of freedom steerable devices. Longitudinal guide structures (e.g., channels or bores) and/or anchor points for shape memory alloy wire elements may be circumferentially spaced in or on the tubular elements to receive the shape memory alloy wire elements.
Systems and methods are described for performing logical filtering of hazard alerts by an area of geography the hazard is expected to impact and issuing alerts based on that area. Based on a geographical location, a hazard type, and a hazard severity, one or more geographic areas the hazard is expected to impact may be determined. One or more automated alerts may be issued to alert users in those areas that could be affected by the hazard.
G08B 21/10 - Alarmes pour assurer la sécurité des personnes réagissant aux événements désastreux, p. ex. les tornades ou les tremblements de terre
G08B 25/10 - Systèmes d'alarme dans lesquels l'emplacement du lieu où existe la condition déclenchant l'alarme est signalé à une station centrale, p. ex. systèmes télégraphiques d'incendie ou de police caractérisés par le moyen de transmission utilisant des systèmes de transmission sans fil
G08B 31/00 - Systèmes d'alarme à prédiction caractérisés par une extrapolation ou un autre type de calcul utilisant des données historiques mises à jour
Methods, systems, and apparatus for fabricating a circuit board. The method includes fabricating, using an additive manufacturing device, a trace layer, a sacrificial layer, a rail layer and a lid. The method includes placing the sacrificial layer on the trace layer such that the raised traces protrude through corresponding openings of the sacrificial layer. The method includes depositing a conductive material on top of the sacrificial layer and the plurality of traces. The method includes removing the sacrificial layer from the trace layer and placing the rail layer on the trace layer such that the raised traces align with the corresponding openings of the rail layer. The method includes connecting one or more electrical components and melting a sealing sheet on top of the rail layer and the electrical components to reinforce connections and to provide protection. The method includes placing the lid on top of the sealing sheet.
H05K 3/18 - Appareils ou procédés pour la fabrication de circuits imprimés dans lesquels le matériau conducteur est appliqué au support isolant de manière à former le parcours conducteur recherché utilisant la technique de la précipitation pour appliquer le matériau conducteur
H05K 3/38 - Amélioration de l'adhérence entre le substrat isolant et le métal
Perishable products, such as food products, can be preserved by cooling to temperatures below their freezing point without ice crystallization. In some embodiments, the perishable product is cooled to temperatures below the freezing point of water while a pulsed electric field and oscillating magnetic field are applied to the product. Apparatus for supercooling perishable products are also provided and include a pulsed electric field generator and an oscillating magnetic field generator.
A23L 3/26 - Conservation des aliments ou produits alimentaires, en général, p.ex. pasteurisation ou stérilisation, spécialement adaptée aux aliments ou produits alimentaires par irradiation sans chauffage
A23L 3/32 - Conservation des aliments ou produits alimentaires, en général, p.ex. pasteurisation ou stérilisation, spécialement adaptée aux aliments ou produits alimentaires par traitement avec des courants électriques sans effet de chauffage
Apparatuses and methods for harvesting ambient energy involve repeated circuit reconfiguration. An apparatus includes a primary charge storage device, a first secondary charge storage device, a second secondary charge storage device, and switching circuitry. The switching circuitry is configured to cyclically alter connection of the first and second secondary charge storage devices between a series state and a parallel state. First and second moveable electrically conductive elements may include electrically conductive liquid droplets of materials such as water or mercury. At least one of the primary storage device, the first secondary charge storage device, or the second secondary charge storage device includes a capacitance that varies in response to receipt of ambient energy. Concurrently altering relative capacitance and circuit configuration results in exponential growth of harvested energy.
H02N 1/08 - Générateurs à influence avec porteur de charge conducteur, c.-à-d. machines à capacité
H02M 3/07 - Transformation d'une puissance d'entrée en courant continu en une puissance de sortie en courant continu sans transformation intermédiaire en courant alternatif par convertisseurs statiques utilisant des résistances ou des capacités, p. ex. diviseur de tension utilisant des capacités chargées et déchargées alternativement par des dispositifs à semi-conducteurs avec électrode de commande
87.
Ambient energy harvesting device with charge-carrying movable electrode
Systems, apparatuses and methods for harvesting ambient energy involve an electrically conductive charge-carrying movable electrode. An apparatus includes an electrically conductive charge-carrying electrode, a first dielectric interface region, a second dielectric interface region, and at least one reference electrode. The first and second dielectric interface regions differ in surface charge density. In certain aspects, the movable electrode moves proximate and relative to the first and second dielectric interface regions in response to receipt of ambient energy, thereby providing first and second capacitances. The first capacitance differs from the second capacitance, and/or the first surface charge density differs from the second surface charge density. Movement of the movable electrode in combination with the differing capacitances and/or charge densities results in energy accumulation, thereby enabling ambient energy to be harvested efficiently and effectively.
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Educational services provided in support of university and college innovation and research, namely, providing educational conferences, seminars, workshops, and programs in the fields of emerging technology, business development, science, innovation, and cybersecurity research
Enabling quick feature delivery is essential for product success and is therefore a goal of software architecture design. But how may we determine if and to what extent an architecture is “good enough” to support feature addition and modification, or determine if a refactoring effort is successful in that features may be added more easily? The applications may use Feature Space and Feature Dependency, derived from a software project's revision history that capture the dependency relations among the features of a system in a feature dependency structure matrix (FDSM), using features as first-class design elements. The applications may also use a Feature Decoupling Level (FDL) metric that may be used to measure the level of independence among features.
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (USA)
UNIVERSITY OF HAWAII (USA)
Inventeur(s)
Nichols, Robert A.
Forest, Kelly
Hruby, Victor J.
Abrégé
Peptide analogues of β-amyloid and methods of using said analogues for neuroprotection are described herein. The β-amyloid peptide analogues have a sequence that is at least 50% identical to an N-terminal β-amyloid core fragment. A pharmaceutical composition of the β-amyloid peptide analogues in a pharmaceutically acceptable carrier can be administered to a subject for neuromodulation. The β-amyloid peptide analogues, while lacking neurotoxicity, effectively provides for protective activity against β-amyloid toxicity.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
92.
Bacterial topoisomerase I inhibitors with antibacterial activity
THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (USA)
UNIVERSITY OF HAWAII (USA)
Inventeur(s)
Tse-Dinh, Yuk-Ching
Sun, Dianqing
Abrégé
The present invention provides compounds as bacterial topoisomerase inhibitors with antibacterial activity. The present invention also provides pharmaceutical compositions comprising at least one of the compounds and methods of using the compounds and pharmaceutical compositions as antibacterial agents for treating infectious diseases.
Isoorientin analogues and related compounds that inhibit glycogen synthase kinase-3β activity are provided as are methods of using these compounds in the treatment of cognitive, neurodegenerative or neurological diseases or conditions, as well as cancer, obesity, diabetes, inflammatory or autoimmune disease, cardiovascular disorder, metabolic syndrome X, hair loss, severe acute respiratory syndrome coronavirus, cocaine addiction, dental caries, bone loss and glaucoma.
A01N 25/32 - Ingrédient réduisant l'effet nocif des substances actives vis-à-vis d'organismes autres que les animaux nuisibles, p. ex. réducteurs de toxicité, compositions autodestructrices
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting collaboration within the health sciences, research and medical communities to achieve advances in health planning and in the distribution of and access to primary care, family medicine and healthcare services; public policy research services and advocacy in the fields of primary care, family medicine, healthcare and health planning to build coalitions; promoting public interest and awareness of the importance of primary care, family medicine and healthcare; public advocacy to promote awareness regarding the distribution of and access to primary care, family medicine and healthcare services Educational resource services to improve health and health care, namely, forums, presentations, symposiums and conferences in the fields of primary care, family medicine, healthcare and health planning; Educational resource services to improve health and health care, namely, developing educational curriculum for others in the fields of primary care, family medicine, healthcare and health planning; providing on-line, non-downloadable curriculum, namely, printed and audio-visual curriculum in the fields of primary care, family medicine, healthcare and health planning; Educational resource services to improve health and health care, namely, providing on-line non-downloadable presentations, articles, research summaries, commentaries, editorials, monographs and books in the fields of primary care, family medicine, healthcare and health planning Health care services, namely, providing health care information
96.
ACTIVATED MAGNESIUM BORIDE MATERIALS FOR HYDROGEN STORAGE
Some embodiments described herein provide for methods for synthesizing magnesium borohydride from hvdrogenation of magnesium boride at moderate temperature and pressure in the presence of a modifier. The modifier may be in form of hydrides, liquid hydrogen carriers, ammonia borane, metallic species, croconate anion based materials, ethers, amines or imines, metal carbides, borides, graphene, arenes, magnesium, aluminum, calcium or ionic liquids. Some embodiments provide for charging magnesium boride in presence of a modifier at high pressure hydrogen while simultaneously heating the material. The modification in some instances may lead to an improved magnesium boride product with enhanced properties for application in other hydrogen storage systems.
Provided herein are compositions that include an isolated glycosylated polypeptide comprising at least 50 amino acid residues of a surface glycoprotein of a filovirus and a pharmaceutically acceptable carrier. The glycosylated polypeptide corresponds to one or more structural subunits of the glycoprotein. When the compositions are administered to a subject, they stimulate an innate immune response. The response can be stimulated with administration in the absence of an adjuvant. Methods of using the compositions and for their production are also disclosed.
In one aspect, an embodiment of this invention comprises an apparatus for updating an active fuel gauge of a battery cell. The apparatus comprises a memory, a sensor, and a processor. The memory stores data regarding an active fuel gauge of the battery cell based on a first voltage and state of charge (SOC) relationship. The processor receives first, second, and third resting voltage measurements at different times. The processor calculates differences in capacity between pairs of the resting voltage measurements based on the first voltage and state of charge (SOC) relationship. When the differences are equal the reference capacity difference, the processor identifies an estimate of a remaining capacity of the battery cell corresponding with the active fuel gauge. When the differences are not equal to the reference capacity difference, the processor updates the active fuel gauge based on an identified second voltage and SOC relationship.
G01R 31/367 - Logiciels à cet effet, p. ex. pour le test des batteries en utilisant une modélisation ou des tables de correspondance
G01R 31/392 - Détermination du vieillissement ou de la dégradation de la batterie, p. ex. état de santé
G01R 31/3842 - Dispositions pour la surveillance de variables des batteries ou des accumulateurs, p. ex. état de charge combinant des mesures de tension et de courant
G01R 31/3835 - Dispositions pour la surveillance de variables des batteries ou des accumulateurs, p. ex. état de charge ne faisant intervenir que des mesures de tension
99.
Blood volume assessment using high frequency ultrasound
The present disclosure generally relates to using high frequency ultrasound to assess blood volume changes in a subject. A baseline blood volume value can be determined based on a weight of a subject or based on an initial/previous assessment test value. An image taken with the high frequency ultrasound can be retrieved. A test blood volume value can be measured in a field of view of the image. For example, the test blood volume can be determined based on a destruction/replenishment of a contrast agent during imaging by the high frequency ultrasound. A change in blood volume in the subject can be estimated by comparing the test blood volume value to the baseline blood volume value. The estimate of the change in blood volume can be used to assess a condition of the subject.
A steerable surgical device includes a flexible joint positioned between first and second tubular elements, with multiple shape memory alloy wire elements extending across or through the joint being circumferentially spaced relative to one another and independently actuatable to effectuate pivotal movement between the first and second tubular elements (e.g., along at least two or at least three nonparallel planes) to provide enhanced maneuverability relative to single degree of freedom steerable devices. Longitudinal guide structures (e.g., channels or bores) and/or anchor points for shape memory alloy wire elements may be circumferentially spaced in or on the tubular elements to receive the shape memory alloy wire elements.
