Abrégé

Disclosed herein modified tomato plants, plant cells, plant parts, plant seeds, and fruit comprising targeted modifications to endogenous terpene or terpenoid biosynthetic genes resulting in decreased expression of the endogenous terpene or terpenoid biosynthetic gene relative to a reference plant lacking the modification. The decrease of expression in the endogenous terpene or terpenoid biosynthetic gene results in a depletion of carotene in the fruit of the tomato relative to the reference tomato plant lacking the modification. The disclosure further relates to expression of heterologous terpene or terpenoid biosynthetic genes in the modified tomato plants, and related methods and uses.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales
• C12N 9/02 - Oxydoréductases (1.), p. ex. luciférase
• C12N 9/10 - Transférases (2.)
• C12N 9/88 - Lyases (4.)
• C12N 15/52 - Gènes codant pour des enzymes ou des proenzymes

Abrégé

A new and distinct cultivar of Seashore Paspalum plant, botanically known as Paspalum vaginatum Swartz, named ‘UGP 73’, characterized by its excellent turf quality, excellent turf color, superior drought tolerance, superior salt tolerance and better tolerance to shade than other Paspalum vaginatum cultivars.

Classes IPC  ?

• A01H 6/46 - Gramineae ou Poaceae, p. ex. ivraie, riz, blé ou maïs
• A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique

Abrégé

Thuja plant named ‘RutThu6’, characterized by its compact, rounding form and yellow foliage with orange tips; growth and heat tolerance in USDA Zone 8a, growth in full sun and afternoon shade conditions in landscape and full sun in container production, disease and insect resistance.

Classes IPC  ?

• A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
• A01H 5/12 - Feuilles
• A01H 7/00 - Gymnospermes, p. ex. conifères

Abrégé

Engineered plants typically including a polynucleotide including an expression control sequence(s) operably linked to a nucleic acid sequence encoding a cold-regulated (COR) or COR-like gene are provided. Preferred COR genes include COR6.6, COR15A, COR15B, and homologues, orthologues, and paralogues thereof. The expression control sequence(s) can be or include a promoter, transcriptional terminator, a sequence that enhances expression or regulation or a combination thereof. Also provided are methods of using the engineered plants and parts and cells thereof. For example, a method of growing an engineered plant, e.g., a transgenic plant, can include planting the engineered plant or a part thereof such as seeds. The engineered plants are particularly advantageous for growing on marginal lands. Thus, the plants can be grown on land characterized by insufficient water supply, a severe slope, erosion, salinization, low organic carbon contents, is desert or desert adjacent, or any combination thereof.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

The present invention provides constructs of the parainfluenza virus type-5 (PIV5) virus expressing the SARS-CoV-2 envelope spike (S) protein for use as safe, stable, efficacious, and cost-effective vaccines against COVID-19.

Classes IPC  ?

• A61K 39/215 - Coronaviridae, p. ex. virus de la bronchite infectieuse aviaire
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• C12N 15/86 - Vecteurs viraux

Abrégé

Described herein are home compostable adhesives composed of a polyester. The adhesives described herein have widespread commercial applicability as a compostable alternative to current non-biodegradable adhesives such as, for example, pressure sensitive adhesives. In one aspect, the polyester includes (a) a plurality of residues of a diol selected from the group consisting of 1,3-propanediol, 1,4-butanediol, or a combination thereof; (b) a plurality of residues of a first dicarboxylic consisting of succinic acid; (c) a plurality of residues of a second dicarboxylic consisting of glutaric acid; and (d) a plurality of residues of a sugar.

Classes IPC  ?

• C09J 167/06 - Polyesters non saturés comportant des insaturations carbone-carbone
• C09J 7/25 - Matières plastiquesMatières plastiques métallisées à base de composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
• C08G 63/16 - Acides dicarboxyliques et composés dihydroxylés
• C09J 131/06 - Homopolymères ou copolymères d'esters d'acides polycarboxyliques
• C09J 167/02 - Polyesters dérivés d'acides dicarboxyliques et de composés dihydroxylés

Abrégé

Infectious diseases continue to burden populations around the world. Both naturally occurring and engineered biological threats hold increasing potential to cause disease, disability, and death. The liposomes comprise a targeting molecule that binds a target antigen expressed by a pathogen, wherein the targeting molecule is a C-Type Lectin polypeptide or a fragment thereof comprising a carbohydrate recognition domain (CRD), wherein the targeting molecule is incorporated into the outer surface of the liposome. Provided herein are targeted nanoparticle compositions and methods for the diagnosis, treatment or prevention of an infectious disease using same.

Classes IPC  ?

• A61K 9/1271 - Liposomes non conventionnels, p. ex. liposomes modifiés par un PEG ou liposomes enduits de ou greffés avec des polymères
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61P 31/04 - Agents antibactériens
• A61P 31/06 - Agents antibactériens pour le traitement de la tuberculose
• A61P 31/10 - Antifongiques
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose

Abrégé

Described herein are adhesives composed of a polyester. In one aspect, the polyester described herein is compostable, and the adhesives described herein have widespread commercial applicability as a compostable alternative to current non-biodegradable adhesives. The polyesters described herein are suitable for use in a wide variety of adhesives, such as, for example, pressure sensitive adhesives, including compostable pressure sensitive adhesives. In one aspect, the polyester disclosed herein provides both adhesion and tack, allowing pressure sensitive adhesives to be formulated without adding a separate tackifier.

Classes IPC  ?

• C09J 167/02 - Polyesters dérivés d'acides dicarboxyliques et de composés dihydroxylés
• C09J 167/08 - Polyesters modifiés soit par des huiles grasses supérieures ou leurs acides, soit par des résines naturelles ou des acides résiniques
• C09J 7/38 - Adhésifs sensibles à la pression
• C09J 167/04 - Polyesters dérivés des acides hydroxycarboxyliques, p. ex. lactones

Abrégé

Described herein are home compostable adhesives composed of a polyester. The adhesives described herein have widespread commercial applicability as a compostable alternative to current non-biodegradable adhesives such as, for example, pressure sensitive adhesives. In one aspect, the polyester includes a plurality of residues of a diol selected from the group consisting of 1,3-propanediol, 1,4-butanediol, or a combination thereof; a plurality of residues of a first dicarboxylic consisting of succinic acid; a plurality of residues of a second dicarboxylic consisting of glutaric acid; and a plurality of residues of a sugar.

Classes IPC  ?

• C09J 167/02 - Polyesters dérivés d'acides dicarboxyliques et de composés dihydroxylés
• B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
• B32B 27/36 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyesters
• C08G 63/02 - Polyesters dérivés soit d'acides hydroxycarboxyliques, soit d'acides polycarboxyliques et de composés polyhydroxylés
• C08G 63/12 - Polyesters dérivés soit d'acides hydroxycarboxyliques, soit d'acides polycarboxyliques et de composés polyhydroxylés dérivés d'acides polycarboxyliques et de composés polyhydroxylés
• C08G 63/16 - Acides dicarboxyliques et composés dihydroxylés
• C09J 7/38 - Adhésifs sensibles à la pression

Abrégé

The new variety of blueberry ‘CBG-23-02’ is characterized by having large, firm berries with excellent color and a long shelf life. The berries have a sweet, aromatic flavor with mild acidity. Further, the berries of the new variety ‘CBG-23-02’ are crunchy with a smooth texture and clean finish. The fruit of the new variety ‘CBG-23-02’ ripens early in the season.

Classes IPC  ?

• A01H 5/08 - Fruits
• A01H 6/36 - Ericaceae, p. ex. azalée, canneberge ou myrtille

Abrégé

The new variety of blueberry ‘CBG-23-05’ is characterized by having large, firm, berries with excellent color. The berries ripen early in the season and have a long shelf life. Further, the berries of the new variety ‘CBG-23-05’ are crunchy, with moderate sweetness and mild acidity.

Classes IPC  ?

• A01H 5/08 - Fruits
• A01H 6/36 - Ericaceae, p. ex. azalée, canneberge ou myrtille

Abrégé

The new variety of blueberry ‘CBG-23-04’ is characterized by having large, firm, berries that ripen early in the season and have a long shelf life. Further, the berries of the new variety ‘CBG-23-04’ are crunchy with a very sweet, floral taste.

Classes IPC  ?

• A01H 5/08 - Fruits
• A01H 6/36 - Ericaceae, p. ex. azalée, canneberge ou myrtille

Abrégé

Described herein are orotic acid esters and amides as nucleators for crystallizing molten poly(hydroxyalkanoates). The orotic acid esters and amides are soluble in the molten poly(hydroxyalkanoates) and have high nucleating efficiencies. The use of the orotic acid esters and amides described herein provide several advantages with respect to producing articles composed of thepoly(hydroxyalkanoates).

Classes IPC  ?

• C08L 67/04 - Polyesters dérivés des acides hydroxycarboxyliques, p. ex. lactones
• C08J 9/06 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement utilisant des gaz de gonflage produits par un agent de gonflage introduit au préalable par un agent chimique de gonflage
• C08J 9/20 - Fabrication de particules expansibles par polymérisation en suspension en présence de l'agent de gonflage
• C07D 239/557 - Deux atomes d'oxygène liés par une liaison double ou sous forme de radicaux hydroxyle non substitués avec d'autres hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle avec des atomes de carbone comportant trois liaisons à des hétéro- atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle, p. ex. acide orotique
• C08J 3/22 - Formation de mélanges de polymères avec des additifs, p. ex. coloration en utilisant les techniques des charges mères

Abrégé

50Sp5050 value of 1.3 nM and was more potent against several HBV mutants than entecavir.

Classes IPC  ?

• C07D 473/34 - Atome d'azote lié en position 6, p. ex. adénine
• C07F 9/6561 - Composés hétérocycliques, p. ex. contenant du phosphore comme hétéro-atome du cycle contenant des systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un carbocycle ou un système carbocyclique commun, avec ou sans autres hétérocycles non condensés
• C07D 473/18 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 un atome d'oxygène et un atome d'azote, p. ex. guanine
• C07D 239/47 - Un atome d'azote et un atome d'oxygène ou de soufre, p. ex. cytosine
• C07F 9/6512 - Cycles à six chaînons les atomes d'azote étant en positions 1 et 3
• C07D 239/54 - Deux atomes d'oxygène liés par une liaison double ou sous forme de radicaux hydroxyle non substitués
• C07D 249/10 - Triazoles-1, 2, 4Triazoles-1, 2, 4 hydrogénés avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
• A61K 31/52 - Purines, p. ex. adénine
• A61K 31/675 - Composés du phosphore ayant l'azote comme hétéro-atome d'un cycle, p. ex. phosphate de pyridoxal
• A61P 31/20 - Antiviraux pour le traitement des virus ADN

Abrégé

A method and system for diagnosing an idiopathic psychosis patient and improving treatment targeting for that patient. Cognitive performance is measured on the patient. Pro- and anti-saccade signals are measured on the patient. Motor inhibition is measured on the patient. EEG signals are measured on the patient. Principal components analysis is applied to the measured signals and scales to determine the most significant features. The patient is evaluating on at least 11 dimensions of neuro-cognitive performance. A trained numerical taxonomy approach is used to classify the patient as belonging to a B-SNP psychosis Biotype and the patient's condition is categorized based on the classified Biotype. The B-SNIP psychosis Biotype is used to implement targeted treatment for an individual patient. The diagnostic algorithm is continuously re-trained using new cases and new laboratory tests to improve precision of B-SNIP psychosis Biotypes diagnosis and the accuracy of selecting treatments for individual patients.

Classes IPC  ?

• G16H 20/10 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des médicaments ou des médications, p. ex. pour s’assurer de l’administration correcte aux patients
• G16H 20/70 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mentales, p. ex. la thérapie psychologique ou le training autogène
• G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux

Abrégé

Provided herein are cancer-targeted nanoparticles for the treatment or prevention of cancer.

Abrégé

Nanoparticles and formulations for treating prostate cancer in a subject are disclosed. The nanoparticles contain a cage, such as a zeolitic imidazolate framework (“ZIF”), a surface modifying agent, a targeting ligand, and an active agent. The surface modifying ligand is attached to the outer surface of the cage and the targeting ligand is exposed to the surrounding environment. The active agent is encapsulated in the cage. The targeting ligand binds to a reproductive hormone or a receptor of a reproductive hormone. The active agents can be a ribosome inactivating protein, an apoptosis inducer, a hormone, a receptor ligand, or a nucleic acid, or a chemotherapy drug or a combination thereof, that kill and/or reduce or prevent growth or proliferation of gonadotroph cells and/or tumor cells, regulate FSH and/or LH secretion, and/or interfere with androgen production. Uses for formulations incorporating the nanoparticles for treating cancer in a subject are also disclosed.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61K 47/56 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique
• A61P 35/00 - Agents anticancéreux
• B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments

Abrégé

Provided are methods for predicting viability of a live cell and non-destructive models for analyzing live cells. Cell viability prediction includes imaging a live cell to provide a 3D bright-field image of the live cell, and feeding the 3D bright-field image to a pipeline model to classify the live cell for viability. The pipeline model includes a fluorescence prediction model that generates a 3D predicted fluorescence map and a classification model that classifies the 3D predicted fluorescence map. Methods for training the pipeline model are also provided.

Classes IPC  ?

• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G06N 3/08 - Méthodes d'apprentissage
• G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
• G06T 7/00 - Analyse d'image

Abrégé

Thuja plant named ‘RutThu7’, characterized by its nice columnar form, dark green foliage that does not have chartreuse tips and lack of stem canker and root rot issues can be grown in USDA Zone 8a and is well suited for small urban gardens.

Classes IPC  ?

• A01H 7/00 - Gymnospermes, p. ex. conifères

Abrégé

Disclosed herein are dual-specificity (DS) aptamers involving modular designed RNA that connect two aptamer motifs with a linker domain. In cells, they induce proximity between O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) and a designated protein, and increase or decrease O-GlcNAcylation on the substrate. These RNA aptamers have short half-lives in cells and their binding can be controlled by riboswitches.

Classes IPC  ?

• C12N 15/115 - Aptamères, c.-à-d. acides nucléiques liant spécifiquement une molécule cible avec une haute affinité sans s'y hybrider

Abrégé

The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes TAB1. Also provided are methods of making and using these constructs, such as for the treatment of conditions mediated by atypical p38 signaling.

Classes IPC  ?

• A61P 27/02 - Agents ophtalmiques
• C07K 16/18 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire

Abrégé

Herein provided is a new valencia-type peanut variety designated ‘Georgia-Val/HO’ as well as the seeds, plants and derivatives of the new peanut variety ‘Georgia-Val/HO’. Methods for producing peanut plants by crossing the new peanut variety ‘Georgia-Val/HO’ with itself or another peanut variety (such as another valencia-type peanut variety) and plants produced by such methods are also provided. ‘Georgia-Val/HO’ is a unique valencia-type peanut cultivar having a combination of a moderate level of tomato spotted wilt virus (TSWV) resistance, high-oleic, high total sound mature kernel (TSMK) percentage, and high yield. ‘Georgia-Val/HO’ provides a medium maturity valencia-type peanut cultivar with a runner growth habit, prominent main stem, dark green foliage, runner seed size, and red seedcoat color.

Classes IPC  ?

• A01H 6/54 - Leguminosae ou Fabaceae, p. ex. soja, luzerne ou arachide
• A01H 5/10 - Graines

Abrégé

Provided are an immunogenic multivalent (e.g., pentavalent or octavalent) composition, vaccine, and formulations thereof, composed of five or eight, isolated, non-naturally occurring, immunogenic antigens derived from influenza viruses that are capable of eliciting a broadly reactive immune response, e.g., a broadly reactive neutralizing antibody response directed against influenza virus antigens, following introduction into a subject. Also provided are immunogens and virus-like particles (VLPs) comprising the multivalent composition. Methods of generating an immune response in a human or non-human subject by administering the multivalent composition are provided. In particular, the multivalent immunogen comprises isolated, broadly reactive hemagglutinin (HA) protein antigens of influenza virus strains, such as H1, H3, and IBV, and/or viral neuraminidase (NA) N1 and N2 protein antigens, which may be recombinant and/or recombinantly produced.

Classes IPC  ?

• A61K 39/145 - Orthomyxoviridae, p. ex. virus de l'influenza
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus

Abrégé

Methods of making assembloids, the assembloids, compositions made from and/or including assembloids, and methods of using the foregoing are provided. Methods of making assembloids typically include combining dissociated neuron progenitor cells with dissociated tissue progenitor cells and culturing them under free floating 3D culture conditions suitable for the neuron progenitor cells and tissue progenitor cells to form one or more assembloids. In some forms, the assembloids are cultured under suitable conditions and duration for the neuron progenitor cells and tissue progenitor cells to mature. The neuron progenitor cells can be, for example, sympathetic neuron progenitor cells, parasympathetic neuron progenitor cells, and/or sensory neuron progenitor cells. The tissue progenitor cells can be, for example, heart, lung, kidney, liver, salivary gland, skin, and/or gastro-intestinal progenitor cells. Assembloids are also provided, as are compositions including assembloids, and conditioned media formed from assembloids.

Classes IPC  ?

• C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique

Abrégé

A new and distinct plant of Zoysia plant named ‘16-TZ-14114’, characterized by its wide leaf texture and vigorous growth, which results in fast establishment after planting. The Zoysia plant named ‘16-TZ-14114’ is an asexually reproduced, tetraploid plant is reliably propagated vegetatively, although it is not seed or pollen sterile.

Classes IPC  ?

• A01H 6/46 - Gramineae ou Poaceae, p. ex. ivraie, riz, blé ou maïs
• A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
• A01H 5/12 - Feuilles

Abrégé

In accordance with the purpose(s) of the present disclosure, as embodies and broadly described herein, the disclosure, in one aspect, relates to nitric oxide releasing compositions and a method of making nitric oxide releasing compositions. The compositions can include a nitric oxide releasing compound and other components, such as ethanol, water, a thickening agent, a polyol, and a neutralizer. The compositions described herein can be used to reduce or prevent the growth of microbes on a surface.

Classes IPC  ?

• A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
• A61K 39/42 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire viraux
• A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire

Abrégé

Described herein are methods for preventing microbial infections derived from an implanted catheters when not in use. In one aspect, the method involves filing the implanted catheter when not in use with a lock solution comprising a pharmaceutically acceptable salt of methanetrisdiazeniumdiolate and a pharmaceutically acceptable carrier. The lock solution releases nitric oxide and Azanone, which makes the lock solution a highly effective antimicrobial agent. The lock solution and use thereof can be effective in reducing or preventing particularly dangerous infections such as, for example, bloodstream infections.

Classes IPC  ?

• A61L 29/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 29/14 - Matériaux caractérisés par leur fonction ou leurs propriétés physiques
• A61L 33/00 - Traitement antithrombogénique d'articles chirurgicaux, p. ex. de sutures, cathéters, prothèses ou d'articles pour la manipulation ou le conditionnement du sangMatériaux pour un tel traitement
• A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres

Abrégé

Coating compositions, coated articles including the coating compositions, and methods of making the coating compositions and coated articles are provided. In some aspects, the coating compositions are applied to a substrate having nitric oxide-releasing properties. The coating compositions can include copolymers having crosslinking agents that can be activated with mild UV light (about 345 nm to 365 nm) to avoid damaging the substrate while creating strong covalent bonds to the substrate. The copolymers can include hydrophilic repeat units, and in particular zwitterionic repeat units such as repeat units containing phosphorylcholine groups. In some aspects, the coating compositions are applied to a surface of a polymer substrate, wherein the polymer substrate had nitric oxide releasing properties. The coating compositions and the coated articles can have antifouling, antithrombotic, and/or antibacterial properties.

Classes IPC  ?

• C09D 133/10 - Homopolymères ou copolymères d'esters de l'acide méthacrylique
• A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
• A61L 29/08 - Matériaux de revêtement
• A61L 29/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques

Abrégé

The present invention relates to novel methods for synthesizing L-BDHU and related starting materials and intermediate compounds from (7?J-2,2-dimethyl-l,3-dioxolane-4- carboxylate (7) in as few as 7 steps. The present invention eliminates expensive chiral purification of L-di oxolane (11), resulting in enantiomerically enriched (ee > 99%) compound. The optically pure compound 11 was utilized to construct L-BHDU (15) and its monophosphate prodrug (POM-L-BHDU, 22). Novel methods of synthesis and novel intermediate compounds represent additional embodiments of the present invention.

Classes IPC  ?

• C07D 317/32 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant deux atomes d'oxygène comme uniques hétéro-atomes du cycle comportant les hétéro-atomes en positions 1, 3 non condensés avec d'autres cycles avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
• C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique

Abrégé

The present invention provides Mycoplasma gallisepticum strain K6067 as deposited at the ATCC under Patent Designation PTA-127168, Mycoplasma gallisepticum strain K4110 as deposited at the ATCC under Patent Designation PTA-127282, and progeny and derivatives thereof, for use as a vaccine for the prevention of virulent Mycoplasma gallisepticum infections in the birds of the order Galliformes. Also provided are compositions and methods for administration to birds of the order Galliformes.

Classes IPC  ?

• A61K 39/02 - Antigènes bactériens
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/04 - Agents antibactériens
• C12N 1/20 - BactériesLeurs milieux de culture
• C12R 1/35 - Mycoplasma

Abrégé

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to scaffold molecules that inhibit epidermal growth factor receptor (EGFR), the methods of making same, the pharmaceutical compositions comprising same, and the methods of treating cancers involving aberrant EGFR activity.

Classes IPC  ?

• C07D 239/94 - Atomes d'azote
• A61K 31/517 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. quinazoline, périmidine
• A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
• A61P 35/04 - Agents anticancéreux spécifiques pour le traitement des métastases
• C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons

Abrégé

Disclosed are novel H1N1 antigen binding molecules and methods of their use for the treatment and/or prevention of influenza A virus.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 37/04 - Immunostimulants

Abrégé

Described herein are methods for producing omniphobic coating compositions. The methods provide an extremely facile and economic synthetic process that can be extended to a wide range of substrates for widespread real-world applicability. The omniphobic coating compositions produced herein possess numerous advantageous properties including, but not limited to, high physical durability, aqueous chemical stability, thermal and UV resistance, prolonged room temperature storage, cytocompatibility and impeccable anti-biofouling properties including anti-platelet adhesion. In one aspect, the omniphobic coating composition is produced by the method comprising (a) functionalizing a surface of the article with a plurality of nucleophilic groups to produce a pre-functionalized surface, and (b) contacting the pre-functionalized surface with a perfluorolkylsiloxane comprising an electrophilic group, wherein the plurality of nucleophilic groups on the surface of the article react with the electrophilic group on the perfluoroalkylsiloxane to covalently bond the perfluoroalkylsiloxane to the surface of the article.

Classes IPC  ?

• C08G 77/42 - Polymères séquencés ou greffés contenant des segments de polysiloxanes
• C09D 7/65 - Adjuvants macromoléculaires
• C09D 7/40 - Adjuvants
• C08G 77/442 - Polymères séquencés ou greffés contenant des segments de polysiloxanes contenant des segments de polymères vinyliques

Abrégé

Pre-impaction devices and methods of creating imperfections or weaknesses in the outer layer of an object. Pre-impaction devices are used to create imperfections or weaknesses in an object's outer layer such that removal of the outer layer does not damage items on the interior of the object.

Classes IPC  ?

• A23N 5/00 - Machines à écaler, cerner ou casser les noix

Produits et services

Non-artificial turf; Live plants, namely, bermudagrass; Sod

Abrégé

Described and featured are immunogenic compositions comprising non-naturally occurring pan-fungal kexin peptides and methods of using such compositions for the treatment or prevention of various diseases or severe diseases, and/or the symptoms thereof, particularly those associated with infection by fungal pathogens (e.g., Pneumocystis, Aspergillus, Candida, or Cryptococcus) in the subject. The immunogenic peptides or immunogenic fragments thereof may be recombinantly produced, recombinant, and/or isolated.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 31/10 - Antifongiques
• C07K 16/40 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre des enzymes
• C12N 9/64 - Protéinases provenant de tissu animal, p. ex. rennine

Produits et services

Non-artificial turf; Live plants, namely, bermudagrass; Live plants, namely, grass sod, sprigs and plugs; Sod

Produits et services

Live plants; Live plants, namely, blueberry

Abrégé

Described herein are glycan compounds and particles comprising glycan compounds. The compounds and particles described herein are useful in methods of treating immune and inflammatory-related diseases. or a pharmaceutically acceptable salt thereof Described herein are glycan compounds and particles comprising glycan compounds. The compounds and particles described herein are useful in methods of treating immune and inflammatory-related diseases. or a pharmaceutically acceptable salt thereof

Classes IPC  ?

• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• C07H 15/12 - Radicaux acycliques non substitués par des structures cycliques liés à un atome d'azote d'un radical saccharide
• C07H 15/18 - Radicaux acycliques substitués par des carbocycles
• C07H 15/26 - Radicaux acycliques ou carbocycliques substitués par des hétérocycles

Abrégé

Provided herein are lipid nanoparticles comprising an anionic lipid component, wherein the lipid nanoparticles comprise a hydrophilic protein that is encapsulated in the lumen of the lipid nanoparticles. Methods of making and using the lipid nanoparticles are also provided. Also included are methods of editing the genome of a cell using the lipid nanoparticles provided herein.

Classes IPC  ?

• A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 9/51 - Nanocapsules

Abrégé

This disclosure relates to methods of isolating rare or non-dominant serotypes of Salmonella species from a sample. The disclosure further relates to the isolation of non-dominant serotypes of Salmonella in a sample related to one or more products for human or animal consumption.

Classes IPC  ?

• C12Q 1/689 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les bactéries
• C12Q 1/24 - Méthodes d'échantillonnage, d'inoculation ou de développement d'un échantillonMéthodes pour isoler physiquement un micro-organisme intact
• C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p. ex. séquençage par hybridation [SBH]

Abrégé

Described herein are nitric oxide releasing sponges comprising a sponge material and a nitric oxide releasing compound. The sponges described herein can eradicate a variety of microbes on medical devices. In other embodiments, the sponges can be used in wound healing applications to prevent or limit infection.

Classes IPC  ?

• A61K 9/70 - Bases pour bande, feuille ou filament
• C08K 3/28 - Composés contenant de l'azote
• C08K 3/30 - Composés contenant du soufre, du sélénium ou du tellure

Abrégé

Antibodies and antigen binding fragments that specifically bind to human metapneumovirus (hMPV) F protein and neutralize hMPV are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. The disclosed antibodies, antigen binding fragments, nucleic acids and vectors can be used, for example, to inhibit an hMPV infection or detect a hMPV infection.

Classes IPC  ?

• C07K 16/10 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de virus de virus à ARN
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

The present invention provides Mycoplasma synoviae strain K5885 as deposited at the ATCC under Patent Designation PTA-127167, and progeny and derivatives thereof, for use as a vaccine for the prevention of virulent Mycoplasma synoviae infections in the birds of the order Galliformes. Also provided are compositions and methods for administration to birds of the order Galliformes.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61K 39/02 - Antigènes bactériens
• A61P 31/04 - Agents antibactériens

Abrégé

A bioreactor includes a vessel comprising a wall with an interior surface defining a volume, and a fluid outlet: a cell support insert removably disposed within the vessel: a lid constructed to close the vessel; a fluid inlet; and a fluid distributor in fluid communication with and arranged to receive a fluid flow from the fluid inlet. The fluid distributor has a plurality of fluid delivery ports constructed to deliver fluid onto the cell support insert. The fluid distributor is arranged to apply a shear force of 0.005 Pa to 0.15 Pa to the cells when cell culture media is circulated at a rate of 25 mL/min to 125 mL/min.

Classes IPC  ?

• C12N 5/0775 - Cellules souches mésenchymateusesCellules souches dérivées du tissu adipeux
• C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
• C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
• C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus

Abrégé

Compositions suitable for administration to or ingestion by honey bees and colonies thereof comprising an effective amount of an anthranilic diamide insecticide to reduce or prevent a parasitic insect infestation of the honey bees' hive are provided. In some embodiments, the composition is non-toxic and optionally, but preferably nutritional to the bees. In some embodiments, the composition further includes a source of carbohydrates, proteins, lipids, vitamins, minerals, water, or a combination thereof. Such sources can be, for example, natural or artificial nectar, honey, sugar, sugar syrup, pollen or pollen substitute, soy flour, soy meal, gluten, skim milk, yeast, pollard, oil, or combinations thereof. Preferred anthranilic diamides are chlorantraniliprole and flubendiamide, preferably wherein the amount of the anthranilic diamide is below the contact and/or oral LD50 for the bee. Devices for delivering the compositions and method of use thereof are also provided.

Classes IPC  ?

• A01N 43/56 - Diazoles-1,2Diazoles-1,2 hydrogénées
• A01N 25/00 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, caractérisés par leurs formes, ingrédients inactifs ou modes d'applicationSubstances réduisant les effets nocifs des ingrédients actifs vis-à-vis d'organismes autres que les animaux nuisibles
• A01P 7/04 - Insecticides

Abrégé

Chimeric polypeptides, chimeric fusion proteins, immunogenic compositions, and methods of use thereof for pan-pneumovirus vaccination are provided. The chimeric polypeptides typically include immunodominant epitopes of the fusion protein of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), and preferably include one or more of antigenic sites Ø, V, and II of RSV, and III, IV, and DS7 of hMPV. The chimeric polypeptides can be utilized as the antigenic domain in chimeric fusion proteins include one or more additional domains such as a signal peptide sequence, a trimerization domain, a cleavage site, a purification tag or report sequence, and one or more linker sequences. Nucleic acids encoding the chimeric polypeptides and chimeric fusion proteins are also provided, as are recombinant viruses having the same. Pharmaceutical compositions including one or more of the foregoing compositions, and methods of there use for immunizing subjects against RSV and hMPV are also provided.

Classes IPC  ?

• A61K 39/12 - Antigènes viraux
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 37/04 - Immunostimulants
• C07K 14/005 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de virus
• C12N 15/86 - Vecteurs viraux

Abrégé

An exemplary system and method are disclosed that can mitigate online social engineering attacks at scale using a real-time detection system configured to identify social engineering advertisements and to block users' navigation to potential social engineering websites. To detect SE-ads and block the subsequent events, the exemplary system and method can monitor a user's browsing session and evaluate each navigation to determine if it may be related to an SE-ad using trained AI features related to how the navigation was initiated and employing the features in a classification evaluation. Upon detection, the exemplary system and method can output a notification to warn the user.

Classes IPC  ?

• H04L 9/40 - Protocoles réseaux de sécurité

Produits et services

Live plants; Live plants, namely, muscadine

Abrégé

Nanoparticles and formulations for preventing or reducing peri-/post-menopausal bone loss and/or obesity in a subject are disclosed. The nanoparticles contain a cage, such as a zeolitic imidazolate framework (“ZIF”), a surface modifying agent, a targeting ligand, and an active agent. The surface modifying agent is attached to the outer surface of the cage and the targeting ligand is exposed to the surrounding environment. The active agent is encapsulated in the cage. The targeting ligand binds to a reproductive hormone or a receptor of a reproductive hormone. The active agent can be a ribosome inactivating protein, an apoptosis inducer, a hormone, a receptor ligand, or a nucleic acid, or a combination thereof, that inactivate ribosomes of gonadotroph cells and/or prevent or reduce secretion of follicle-stimulating hormones in the subject. Uses for formulations incorporating the nanoparticles for preventing or reducing peri-/post-menopausal bone loss and/or obesity in a subject are also disclosed.

Classes IPC  ?

• A61K 9/51 - Nanocapsules
• A61K 38/47 - Hydrolases (3) agissant sur des composés glycosyliques (3.2), p. ex. cellulases, lactases

Abrégé

Described are recombinant immunogenic kex peptide antigens, recombinant peptide immunogens, immunogenic compositions, and methods of using such immunogens and compositions for the treatment of and protection against diseases and symptoms thereof associated with infection by or exposure to one or more fungal pathogens. Also provided are compositions and kits for detecting or quantifying the presence of antibodies directed against one or more fungal kex peptide antigens, as well as use of such antibodies to treat and protect against diseases and symptoms thereof associated with infection by or exposure to one or more fungal pathogens.

Classes IPC  ?

• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/10 - Antifongiques
• C07K 14/37 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant de champignons
• C07K 16/14 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de champignons, d'algues ou de lichens
• C12N 9/58 - Protéinases provenant de champignons

Abrégé

Iodide nanoparticles are provided. The nanoparticles can be potassium iodide (KI) nanoparticles, and can be formed of, a radioisotope, preferably 131I or 125I. The nanoparticles can include a coating that can increase the half-life of the particles, serve as a platform for attachment or entrapment of targeting moieties and/or additional active agents, or a combination thereof. Methods of use are also provided. For example, a method of treating a subject for cancer can including sensitizing the subject to radiation therapy by administrating the iodide nanoparticles to the subject in combination with one or more doses of radiation therapy. Methods of treating or imaging a subject can also include administering the subject an effective amount iodide nanoparticles, without the nanoparticles serving as radiosensitizer. In such methods, the nanoparticles typically include a radioisotope or an anticancer active agent, for example 131I, 125I, 124I, or 123I, or a chemotherapeutic agent.

Classes IPC  ?

• A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
• A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
• A61P 35/00 - Agents anticancéreux

Abrégé

Systems and methods for flipping floating oyster cages are disclosed. The system includes a support structure that when in a deployed position, the second end is submerged in water and the first end remains above water, a carriage configured to travel along the support structure and to engage with a floating cage, and a lifting device configured to move the carriage. The carriage includes a carriage guide moveably attached to the support structure, a lift arm attached to the carriage guide, a balance bar attached at the distal end of the lift arm, and a flipping apparatus. The flipping apparatus includes a carriage table coupled to the balance bar at the distal end of the lift arm such that the carriage table rotates about a rotation axis of the balance bar, where the carriage table includes a lifting frame adapted to allow water to flow through the lifting frame.

Classes IPC  ?

• A01K 61/55 - Paniers à cet effet

Abrégé

The present disclosure provides for devices and systems for detecting biological agents (e.g., virus such as coronavirus) using nanotriangles having a capture agent. The present disclosure also includes methods of detecting the presence and amount of the biological agent in a sample, such as saliva, blood, or urine. In addition, the present disclosure provides for a detecting module and a method of making the detecting module, where the detecting module includes the nanotriangles having the capture agent bonded thereto that has an affinity for the biological agent.

Classes IPC  ?

• G01N 21/552 - Réflexion totale atténuée
• G01N 21/25 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes
• G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques

Abrégé

Described herein are compositions and articles for delivering nitric oxide to a subject. The compositions described herein can eradicate pathogens in a subject. In one aspect, the compositions described herein can be applied as a coating to a medical device. In other aspects, the compositions described herein can be used to produce a medical device that can release nitric oxide. The compositions and articles described herein can be used to treat or prevent bacterial infections and biofilm formation in a subject.

Classes IPC  ?

• A61M 31/00 - Dispositifs pour l'introduction ou la rétention d'agents, p. ex. de remèdes, dans les cavités du corps
• A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
• A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
• A61P 1/02 - Préparations stomatologiques, p. ex. médicaments pour le traitement des caries, des aphtes, des périodontites

Abrégé

Described herein are nitric oxide-releasing compositions. In one aspect, the nitric oxide releasing polysiloxane comprises a polysiloxane backbone with one or more nitric oxide releasing moieties pendant to the polysiloxane backbone. The nitric oxide-releasing compositions possess antibacterial properties with respect to both Gram-positive and Gram-negative bacteria. The ease of synthesis and excellent antibacterial effects against both Gram-positive and Gram-negative bacteria without resistance and serious leaching concerns makes the nitric oxide-releasing compositions useful as lubricants for medical devices and other articles where it is desirable to reduce or prevent bacterial infection.

Classes IPC  ?

• C09D 183/08 - Polysiloxanes contenant du silicium lié à des groupes organiques contenant des atomes autres que le carbone, l'hydrogène et l'oxygène
• A01N 55/00 - Biocides, produits repoussant ou attirant les animaux nuisibles ou régulateurs de croissance des végétaux, contenant des composés organiques comportant des éléments autres que le carbone, l'hydrogène, les halogènes, l'oxygène, l'azote et le soufre
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
• A61L 2/232 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances solides, p. ex. des granules, des poudres, des blocs, des comprimés en couches ou revêtues
• A61L 101/46 - Composés macromoléculaires
• C08G 77/26 - Polysiloxanes contenant du silicium lié à des groupes organiques contenant des atomes autres que le carbone, l'hydrogène et l'oxygène groupes contenant de l'azote
• C08G 77/28 - Polysiloxanes contenant du silicium lié à des groupes organiques contenant des atomes autres que le carbone, l'hydrogène et l'oxygène groupes contenant du soufre
• C08G 77/388 - Polysiloxanes modifiés par post-traitement chimique contenant des atomes autres que le carbone, l'hydrogène, l'oxygène ou le silicium contenant de l'azote
• C08G 77/392 - Polysiloxanes modifiés par post-traitement chimique contenant des atomes autres que le carbone, l'hydrogène, l'oxygène ou le silicium contenant du soufre
• C09D 5/14 - Peintures contenant des biocides, p. ex. fongicides, insecticides ou pesticides

Abrégé

The present disclosure provides synthetic polypeptides that mimic the Switch 2 domain of a Rab protein. The synthetic polypeptides described are capable of inhibiting, modulating, or decreasing the interaction between a Rab protein and an RILPL protein. Methods of treating neurological diseases, disorders, or conditions, such as Parkinson's disease, are also provided.

Classes IPC  ?

• C12N 9/12 - Transférases (2.) transférant des groupes contenant du phosphore, p. ex. kinases (2.7)
• A61K 38/08 - Peptides ayant de 5 à 11 amino-acides
• A61P 25/16 - Antiparkinsoniens
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• C07K 7/06 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 5 à 11 amino-acides

Abrégé

Biosensors for detection terephthalic acid (TPA) and methods of their use are provided. The biosensors include a nucleic acid encoding a TphR protein, a promoter regulated by TPA, and a reporter operably linked to the promoter. Vectors and host cells including the biosensors are also provided.

Classes IPC  ?

• C12Q 1/6825 - Détecteurs faisant intervenir la détection d’acides nucléiques
• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• C12Q 1/6853 - Réactions d’amplification d’acides nucléiques utilisant des amorces ou des matrices modifiées
• G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées

Abrégé

The three main peripheral sensory neuron (SN) subtypes, nociceptors, mechanoreceptors, and proprioceptors localize to dorsal root ganglia (DRG) and convey sensations such as pain, temperature, pressure and limb movement/position. Disclosed herein is a chemically defined differentiation protocol that generates all three SN subtypes from the same starting population, as well as methods to enrich for each individual subtypes. The protocol yields high efficiency and purity cultures that are electrically active and respond to specific stimuli. Their molecular character and maturity stage are described and evidence for their use as an axotomy model is exemplified. Cell populations and compositions formed from the resulting cells, as well as methods of their use for disease treatment, drug screening, and modeling of human disorders affecting SNs are also provided.

Classes IPC  ?

• C12N 5/0793 - Neurones
• A61K 35/30 - NerfsCerveauYeuxCellules cornéennesLiquide céphalorachidienCellules souches neuronalesCellules précurseurs neuronalesCellules glialesOligodendrocytesCellules de SchwannAstrogliesAstrocytesPlexus choroïdeTissu de moelle épinière

Abrégé

Described herein are compositions comprising a nitric oxide-releasing material comprising a (i) a polysiloxane network and (ii) a plurality of nitric oxide-donating moieties covalently bonded to the polysiloxane network; and (b) a nanonemulsion comprising a surfactant and a hydrophobic solvent. Also described herein are articles composed of the compositions described herein and methods for using the same. The compositions described herein provide highly sustained, long-term nitric oxide release that have numerous biological activities such as, for example, preventing localized platelet activation, fibrinogen adhesion, and biofilm formation for a prolonged period of time.

Classes IPC  ?

• A61L 29/08 - Matériaux de revêtement
• A61L 29/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61L 31/10 - Matériaux macromoléculaires
• A61L 31/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• C08L 83/04 - Polysiloxanes

Abrégé

Herein provided is a new runner-type peanut variety designated ‘Georgia-21GR’ as well as the seeds, plants and derivatives of the new peanut variety ‘Georgia-21GR’. Methods for producing peanut plants by crossing the new peanut variety ‘Georgia-21GR’ with itself or another peanut variety (such as another runner-type peanut variety) and plants produced by such methods are also provided. ‘Georgia-21GR’ is a unique runner-type peanut cultivar having a combination of a high level of tomato spotted wilt virus (TSWV) resistance, high total sound mature kernel (TSMK) percentage, and high yield. ‘Georgia-21GR’ provides a medium plus maturity runner-type peanut cultivar with a runner growth habit, prominent main stem, medium dark green foliage, runner seed size, and pink seedcoat color.

Classes IPC  ?

• A01H 6/54 - Leguminosae ou Fabaceae, p. ex. soja, luzerne ou arachide
• A01H 5/10 - Graines

Abrégé

Compositions and methods of improving radiation therapy are provided. The composition typically includes an effective amount of 7-DHC or a derivative or analog thereof. The methods typically include administering the composition to a subject in need thereof in combination with one or more doses of radiation therapy, preferably non-ultraviolet radiation therapy. A preferred radiation is ionizing radiation. The compositions and methods can be used to treat tumors, e.g., benign and malignant tumors. Thus, methods of treating cancer are provided. In preferred embodiments, the 7-DHC or a derivative or analog thereof is encapsulated or incorporated into nanoparticles. The particles can be, for example, polymeric nanoparticles, lipoprotein or lipoprotein-like particles, liposomes, inorganic nanoparticles, or a combination thereof. In some embodiments, the 7-DHC or analog thereof is derivatized with a polymer or saccharide, which is some embodiments, can self-assemble into particles. In some embodiments, the nanoparticles further include a targeting agent coupled thereto.

Classes IPC  ?

• A61K 41/00 - Préparations médicinales obtenues par traitement de substances par énergie ondulatoire ou par rayonnement corpusculaire
• A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
• A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
• C07J 9/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, substitués en position 17bèta par une chaîne de plus de deux atomes de carbone, p. ex. cholane, cholestane, coprostane

Abrégé

The present disclosure provides for surface-enhanced Raman spectroscopy (SERS) systems and methods for detecting, analyzing, and/or quantifying biomolecules or biological agents using SERS systems and a neural network model. The biological agent can be a virus, such as a coronavirus (e.g., SARS-CoV-2 or a variant thereof).

Classes IPC  ?

• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 21/65 - Diffusion de Raman
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• G06N 3/0442 - Réseaux récurrents, p. ex. réseaux de Hopfield caractérisés par la présence de mémoire ou de portes, p. ex. mémoire longue à court terme [LSTM] ou unités récurrentes à porte [GRU]
• G06N 3/045 - Combinaisons de réseaux
• G06N 3/0464 - Réseaux convolutifs [CNN, ConvNet]

Abrégé

Described herein are compositions for delivering fluoride ions and nitric oxide to a subject. The compositions described herein include a poloxamer, an alginate, a nitric oxide releasing compound, fluoride ions, and calcium ions. In one aspect, the compositions are hydrogels. The compositions described herein can eradicate oral pathogens and prevent demineralization of teeth in a subject.

Classes IPC  ?

• A61K 31/765 - Polymères contenant de l'oxygène
• A61K 9/06 - OnguentsExcipients pour ceux-ci
• A61K 31/095 - Composés du soufre, du sélénium ou du tellure, p. ex. thiols
• A61K 31/734 - Acide alginique
• A61P 31/04 - Agents antibactériens

Abrégé

In accordance with the purpose(s) of the present disclosure, described herein are synthetic methods for producing piperazinyl and morpholino hydroxylamines in large scale and high yield. The synthetic approach requires a minimal number of steps and can produce piperazinyl and morpholino hydroxylamines on a multi-gram scale.

Classes IPC  ?

• C01B 21/14 - HydroxylamineSes sels
• C07D 241/12 - Composés hétérocycliques contenant des cycles diazine-1,4 ou diazine-1,4 hydrogéné non condensés avec d'autres cycles comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène, des radicaux hydrocarbonés ou des radicaux hydrocarbonés substitués, liés directement aux atomes de carbone du cycle
• C07D 295/24 - Atomes d'oxygène

Abrégé

Compositions and methods for modulating HIF-2α to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2α inhibitor. The HIF-2α inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.

Classes IPC  ?

• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61K 31/015 - Hydrocarbures carbocycliques
• A61K 31/277 - NitrilesIsonitriles ayant un cycle, p. ex. vérapamil
• A61P 21/04 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire de la myasthénie
• A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
• C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes

Abrégé

Therefore, disclosed herein is a composition comprising dietary early glycation products (EGPs) with less than 1 wt % advanced glycation end products (AGEs). Also disclosed is a method for treating or preventing diabetes in a subject, such as type 1 diabetes, type 2 diabetes, or gestational diabetes, that involves administering to a subject in need thereof a composition disclosed herein.

Classes IPC  ?

• A23J 3/08 - Protéines du lait
• A23J 1/20 - Préparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc à partir du lait, p. ex. caséinePréparation des compositions à base de protéines pour l'alimentationOuverture des œufs par grandes quantités et séparation du jaune du blanc à partir du petit-lait

Abrégé

Chamaecyparis pisifera cultivars; foliage that turns golden in the winter and green in the summer for multi-seasonal interest; and a uniform, pyramidal shape.

Classes IPC  ?

• A01H 7/00 - Gymnospermes, p. ex. conifères

Abrégé

Disclosed herein are neural extracellular vesicles (EVs) and methods of using these EVs in the treatment of spinal cord injury, stroke, and traumatic brain injury and neurodegenerative diseases.

Classes IPC  ?

• C12N 5/0793 - Neurones
• A61K 9/50 - Microcapsules
• A61K 9/51 - Nanocapsules
• A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
• A61K 35/30 - NerfsCerveauYeuxCellules cornéennesLiquide céphalorachidienCellules souches neuronalesCellules précurseurs neuronalesCellules glialesOligodendrocytesCellules de SchwannAstrogliesAstrocytesPlexus choroïdeTissu de moelle épinière
• A61K 35/545 - Cellules souches embryonnairesCellules souches pluripotentesCellules souches pluripotentes induitesCellules souches non caractérisées
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
• C12N 5/079 - Cellules neurales
• C12N 5/0797 - Cellules souchesCellules progénitrices
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

In one aspect, the disclosure relates to a sensor for predicting epileptic seizures in a subject. In an aspect, the sensor includes carbon nanotubes (CNTs) functionalized with organic molecules that can reversibly bind pre-seizure volatile organic compounds (VOCs) by IT-IT bonding, polar bonding, van der Waals interactions, and the like. The sensor can detect the pre-seizure VOCs from biological fluids including sweat, saliva, and breath, thus allowing the prediction of a seizure from 10 to 45 minutes before the seizure occurs, allowing a subject wearing the sensor to take actions to ensure safety and/or to alert caregivers. In an aspect, the sensor can be incorporated into a wearable device that also monitors vital signs such as heart rate, body temperature, skin impedance, and/or body movements in order to predict the type of epileptic seizure. Also disclosed are methods of making the sensors and methods for predicting epileptic seizures.

Classes IPC  ?

• A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
• A61B 5/01 - Mesure de la température de parties du corps
• A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire
• A61B 5/024 - Mesure du pouls ou des pulsations cardiaques
• A61B 5/0531 - Mesure de l’impédance de la peau
• A61B 5/08 - Dispositifs de mesure pour examiner les organes respiratoires
• A61B 5/11 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre
• A61B 5/145 - Mesure des caractéristiques du sang in vivo, p. ex. de la concentration des gaz dans le sang ou de la valeur du pH du sang

Abrégé

The present invention relates to methods of replicating viruses in vitro. In particular, the invention relates to a genetically modified population of cells, and/or a population of cells treated with an exogenous compound, wherein the cells are capable of producing more virus than cells lacking the genetic modification and/or lacking treatment with the exogenous compound. The invention also relates to methods of producing populations of such cells, as well as the use of the viruses obtained to prepare vaccine compositions.

Classes IPC  ?

• C12N 7/02 - Isolement ou purification
• A61K 39/12 - Antigènes viraux
• A61K 39/145 - Orthomyxoviridae, p. ex. virus de l'influenza
• A61K 39/17 - Virus de la maladie de Newcastle
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification

Abrégé

The present disclosure is directed to an electro-optic frequency comb having a plurality of cascaded electro-optic modulators driven at sequential lower harmonics, wherein the last megahertz modulation dictating the repetition rate. This architecture can modulate at any individual harmonic and repetition rate without changes to the components. This comb can be used in any applications where a stable and tunable repetition rate is needed.

Classes IPC  ?

• H03L 7/093 - Détails de la boucle verrouillée en phase concernant principalement l'agencement de détection de phase ou de fréquence, y compris le filtrage ou l'amplification de son signal de sortie utilisant des caractéristiques de filtrage ou d'amplification particulières dans la boucle

Abrégé

Plasmodium falciparumPlasmodium falciparumPlasmodium Plasmodium species. In another aspect, the compounds are soluble in aqueous solutions at pH 7.4, making them suitable for oral administration to patients. Also disclosed are methods of making the compounds, pharmaceutical compositions comprising the same, and methods of treating or preventing malaria using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Classes IPC  ?

• A61K 31/426 - 1,3-Thiazoles
• A61K 31/4192 - 1,2,3-Triazoles
• A61K 31/421 - 1,3-Oxazoles, p. ex. pémoline, triméthadione
• A61K 31/4245 - Oxadiazoles
• A61K 31/4418 - Pyridines non condenséesLeurs dérivés hydrogénés ayant un carbocycle lié directement à l'hétérocycle, p. ex. cyproheptadine
• A61K 31/50 - PyridazinesPyridazines hydrogénées
• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61P 33/06 - Antipaludéens

Abrégé

Plasmodium Plasmodium spp. in the parasite's various stages, such as, for example, the erythrocytic and exoerythrocytic stages, and pharmaceutical compositions comprising same. In one aspect, the compounds are tetrahydroacridinones having the structure I described herein. In another aspect, the compounds described herein can be used to treat or prevent malaria in a subject.

Classes IPC  ?

• C07D 219/10 - Atomes d'azote liés en position 9
• A61K 31/473 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes carbocycliques, p. ex. acridines, phénantridines
• A61P 33/06 - Antipaludéens

Abrégé

SalmonellaSalmonellaSalmonellaSalmonella Typhimurium.

Classes IPC  ?

• C12Q 1/10 - Entérobactéries
• C12Q 1/6888 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus

Abrégé

An exemplary system and method are disclosed that is configured to evaluate by interrogation and analysis whether an incoming call from an unknown caller is a robo-call, e.g., a mass-market, spoofed, targeted, and/or evasive robocalls. The exemplary system is configured with a voice interaction model and analytical operation that can first pick up each incoming phone call on behalf of the recipient callee. The exemplary system then simulate natural conversation with the initiating caller by asking/interrogating the caller with a set of pre-stored questions that naturally occur in human conversations. The exemplary system employs the caller's responses to determine whether the call is a robocall or a natural person by assessing via pre-defined analysis for the context and/or expected natural human response.

Classes IPC  ?

• H04L 65/1076 - Passage au crible des communications IP en temps réel, p. ex. pourriel sur la téléphonie Internet [SPIT]
• G10L 15/26 - Systèmes de synthèse de texte à partir de la parole

Abrégé

The present invention provides safe, stable, efficacious, and cost-effective vaccines based on viral expression vectors that include a J Paramyxovirus (JPV) genome including a heterologous nucleotide sequence expressing a heterologous polypeptide inserted within the JPV genome.

Classes IPC  ?

• A61K 39/145 - Orthomyxoviridae, p. ex. virus de l'influenza
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus
• C12N 15/86 - Vecteurs viraux

Abrégé

Synthetic polypeptides are described comprising an amino acid sequence having an α-helical shape that mimics the death domain of FADD, wherein the polypeptides comprise at least one pair of non-natural amino acids inserted into the amino acid sequence, wherein the pair of non-natural amino acids are cross-linked to stabilize the α-helical shape. Methods of treating medical disorders using the synthetic polypeptides are also described.

Classes IPC  ?

• C07K 7/08 - Peptides linéaires ne contenant que des liaisons peptidiques normales ayant de 12 à 20 amino-acides
• C07K 9/00 - Peptides ayant jusqu'à 20 amino-acides, contenant des radicaux saccharide et comportant une séquence entièrement déterminéeLeurs dérivés
• A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
• A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

This disclosure describes peptides useful in treating medical disorders, and more particularly to doubly constrained synthetic polypeptides capable of inhibiting or modulating the activity of Leucine Rich Repeat Kinase 2 (LRRK2).

Classes IPC  ?

• C07K 14/435 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 35/00 - Agents anticancéreux
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
• C12N 15/86 - Vecteurs viraux

Abrégé

Described herein are home compostable adhesives composed of a polyester. The adhesives described herein have widespread commercial applicability as a compostable alternative to current non-biodegradable adhesives such as, for example, pressure sensitive adhesives. In one aspect, the polyester includes a plurality of residues of a diol selected from the group consisting of 1,3-propanediol, 1,4-butanediol, or a combination thereof; a plurality of residues of a first dicarboxylic consisting of succinic acid; a plurality of residues of a second dicarboxylic consisting of glutaric acid; and a plurality of residues of a sugar.

Classes IPC  ?

• C09J 167/02 - Polyesters dérivés d'acides dicarboxyliques et de composés dihydroxylés
• B32B 7/12 - Liaison entre couches utilisant des adhésifs interposés ou des matériaux interposés ayant des propriétés adhésives
• B32B 27/36 - Produits stratifiés composés essentiellement de résine synthétique comprenant des polyesters
• C08G 63/02 - Polyesters dérivés soit d'acides hydroxycarboxyliques, soit d'acides polycarboxyliques et de composés polyhydroxylés
• C08G 63/12 - Polyesters dérivés soit d'acides hydroxycarboxyliques, soit d'acides polycarboxyliques et de composés polyhydroxylés dérivés d'acides polycarboxyliques et de composés polyhydroxylés
• C08G 63/16 - Acides dicarboxyliques et composés dihydroxylés
• C09J 7/38 - Adhésifs sensibles à la pression

Abrégé

The present disclosure relates to a contactless system for monitoring a blood pressure of a subject (e.g., human patient, non-human patient, etc.) based on vibration signals of a structure supporting the subject. The system can include a sensor coupled to the structure. A computing device in data communication with the sensor can obtain realtime sensor data from the sensor, the real-time sensor data may include seismic signal segments recorded at a predetermined sampling rate. The computing device can further filter the sensor data to remove seismic signal segments not related to vital activities and analyze the filtered sensor data to determine continuous and real-time blood pressure measurements of the subject, which include the estimated systolic blood pressure values and estimated diastolic blood pressure values. A user interface can display of at least the blood pressure measurements.

Classes IPC  ?

• A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
• A61B 5/02 - Détection, mesure ou enregistrement en vue de l'évaluation du système cardio-vasculaire, p. ex. mesure du pouls, du rythme cardiaque, de la pression sanguine ou du débit sanguin
• A61B 5/0205 - Évaluation simultanée de l'état cardio-vasculaire et de l'état d'autres parties du corps, p. ex. de l'état cardiaque et respiratoire

Abrégé

Described herein are hydrophobic coating compositions having unique physical properties. The coating compositions are composed of silicon oxide nanoparticles and silicon nanoparticles modified with a perfluorolkylsiloxane. The coating compositions can be applied to any article or any surface of an article where it is desirable to reduce or prevent the growth of bacteria. The articles coated with the hydrophobic coating compositions are subsequently treated with a nitric oxide releasing compound that can prevent the growth of bacteria and adhesion of platelets on the article.

Classes IPC  ?

• C10M 125/26 - Composés contenant du silicium ou du bore, p. ex. silice, sable
• A61L 29/08 - Matériaux de revêtement
• A61L 29/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• C23C 18/31 - Revêtement avec des métaux

Abrégé

Described herein are antibacterial nanoparticles composed of a porphyrin and a nitric oxide donor. In one aspect, the antibacterial nanoparticles are produced by the method comprising (a) admixing a porphyrin with glutathione or a pharmaceutically acceptable salt or ester thereof to produce a first compound and (b) reacting the first compound with a nitric oxide compound, wherein the nitric oxide compound forms a covalent bond with glutathione or the pharmaceutically acceptable salt or ester. The antibacterial nanoparticles are dynamic in their ability to specifically target pathogenic infections while remaining nontoxic towards mammalian cells and can also be used as medical device coatings to prevent infections as well as in treatment and management of diseases like cancer and autoimmune skin disorders.

Classes IPC  ?

• A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
• A01N 25/12 - Poudres ou granulés
• A01N 43/40 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés hétérocycliques comportant des cycles avec un atome d'azote comme unique hétéro-atome du cycle des cycles à six chaînons
• A01P 1/00 - DésinfectantsComposés antimicrobiens ou leurs mélanges
• A61K 9/51 - Nanocapsules
• A61L 17/00 - Matériaux pour suture chirurgicale ou pour ligature des vaisseaux sanguins
• A61L 29/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• A61P 31/04 - Agents antibactériens

Abrégé

castus plant named ‘V12-2-1’ is characterized by a combination of its heavy blooming with violet-blue flowers, its compact form, its short panicle length with closely spaced subpanicles and whoris of florets, and its tendency to re-bloom in late summer or fall.

Classes IPC  ?

• A01H 5/00 - Angiospermes, c.-à-d. plantes à fleurs, caractérisées par leurs parties végétalesAngiospermes caractérisées autrement que par leur taxonomie botanique
• A01H 6/50 - Lamiaceae, p. ex. lavande, menthe ou chia

Abrégé

In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to scaffold molecules that inhibit breakpoint cluster region, chromosome 22 (BCR) and Abelson proto-oncogene 1, chromosome 9 (ABL1) in a subject, methods of making same, pharmaceutical compositions comprising same, and methods of treating cancers involving aberrant BCR and ABL1 activity. In another aspect, the compounds described herein can evade P-gp-mediated efflux in a subject, which makes the compounds effective in treating a Philadelphia chromosome positive (Ph+) leukemia.

Classes IPC  ?

• A61K 31/395 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines
• A61K 31/505 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 31/33 - Composés hétérocycliques

Produits et services

Turfgrass, namely, natural turf; turfgrass, namely seashore paspalum; sod, sprigs, and grass plugs

Abrégé

Probenecid prodrug compounds, and formulations including one or more of probenecid, metabolites and analogs thereof, and prodrugs thereof, and pharmaceutically acceptable salt thereof are provided. Delivery vehicles and pharmaceutical compositions including any of the foregoing are also provided. Methods of using the compounds and compositions to treat viral infections are also provided. In some embodiments, the viral infection is caused by an RNA virus. Particular viruses include, but are not limited to, influenza virus A, influenza virus B, or influenza virus C, respiratory syncytial virus (RSV), coronaviruses, measles virus, mumps virus, Zika virus, and dengue virus. Dosage regimens are also provided.

Classes IPC  ?

• C07C 311/16 - Sulfonamides ayant des atomes de soufre de groupes sulfonamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes sulfonamide lié à des atomes d'hydrogène ou à un atome de carbone acyclique
• A23K 20/111 - Composés aromatiques
• A23K 50/30 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les porcs
• A23K 50/75 - Produits alimentaires spécialement conçus pour des animaux spécifiques pour les oiseaux pour la volaille
• A61K 31/18 - Sulfamides
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Produits et services

Equipment sold as a unit for playing a game for the purpose of quantifying subjective perspectives on a topic, in the form of board games

Abrégé

Herein provided is a new runner-type peanut variety designated ‘Georgia-SP/RKN’ as well as the seeds, plants and derivatives of the new peanut variety ‘Georgia-SP/RKN’. Methods for producing peanut plants by crossing the new peanut variety ‘Georgia-SP/RKN’ with itself or another peanut variety (such as another spanish, valencia, virginia, or runner-type peanut variety) and plants produced by such methods are also provided. ‘Georgia-SP/RKN’ is a unique spanish market-type peanut cultivar having a combination of a high level of resistance to peanut root-knot nematode (RKN) (Meloidogyne arenaria) and a high level of resistance to tomato spotted wilt virus (TSWV), high yield and high-oleic fatty acid content of seed oil. ‘Georgia-SP/RKN’ provides a medium plus maturity spanish market-type peanut cultivar with intermediate decumbent runner growth habit, tan testa color, and large spanish market-type seed size.

Classes IPC  ?

• A01H 6/54 - Leguminosae ou Fabaceae, p. ex. soja, luzerne ou arachide
• A01H 5/10 - Graines

Abrégé

Compositions and methods for improving embryo development, treating idiopathic male factor infertility, and enabling infertile/sub-fertile/sterile men to father their own genetic offspring are provided. Typically, the methods include administering into a male or female gamete or fertilized embryo an effective amount of a compound that increases bioavailability of a TET protein to improve development of an embryo resulting from fertilization of the female gamete by a male gamete. The compound can be administered into the gamete or embryo before, during, or after fertilization. The compound can be administered by an injection such as intracytoplasmic injection. The compound and the male gamete can be administered in combination by intracytoplasmic sperm injection. Methods of making male gametes, and methods of modifying the genome of a male gamete or embryo using an effective amount of a gene editing composition to correct a gene mutation or anomaly in the genome thereof are also provided.

Classes IPC  ?

• C12N 5/073 - Cellules ou tissus embryonnairesCellules fœtales ou tissus fœtaux
• C12N 5/076 - Cellules du spermeSpermatogonies
• C12N 15/90 - Introduction stable d'ADN étranger dans le chromosome

Abrégé

Embodiments of the present disclosure provide for treated articles of tubing having anti-fouling characteristics, methods of making treated articles of tubing, and the like. Disclosed herein are treated articles of tubing impregnated with a silicone oil and a nitric oxide release agent. Also described are methods for preparing a treated article of tubing and methods for delivering a pharmaceutically acceptable fluid to a subject in need thereof, wherein the fluid is transferred from a fluid source through treated articles of tubing to the subject.

Classes IPC  ?

• A61L 29/06 - Matériaux macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone
• A61L 29/08 - Matériaux de revêtement
• A61L 29/16 - Matériaux biologiquement actifs, p. ex. substances thérapeutiques
• C08J 7/046 - Formation de revêtements résistants à l'abrasionFormation de revêtements de durcissement de surface
• C09D 183/04 - Polysiloxanes

Abrégé

Provided herein are isolated, non-naturally occurring, broadly reactive antigens derived from H3 (H3N2) influenza virus that are immunogenic and are capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against H3 (H3N2) viruses following introduction into a subject. Also provided are non-naturally, broadly reactive occurring immunogens, vaccines, virus-like particles (VLPs) and compositions comprising the immunogens and vaccines. Methods of generating an immune response in a subject by administering the isolated immunogens, vaccines, VLPs, or compositions thereof are provided. In particular, the immunogens are recombinant and comprise the hemagglutinin (HA) protein of the H3 (H3N2) influenza virus strain.

Classes IPC  ?

• A61K 39/145 - Orthomyxoviridae, p. ex. virus de l'influenza
• C12N 7/00 - Virus, p. ex. bactériophagesCompositions les contenantLeur préparation ou purification
• A61K 39/12 - Antigènes viraux
• A61P 31/16 - Antiviraux pour le traitement des virus ARN de la grippe ou des rhinovirus

Abrégé

Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or anaolg thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Classes IPC  ?

• A61K 31/195 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
• A61P 31/14 - Antiviraux pour le traitement des virus ARN

Abrégé

Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.

Classes IPC  ?

• A61K 31/4188 - 1,3-Diazoles condensés avec des systèmes hétérocycliques, p. ex. biotine, sorbinil
• A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
• A61K 49/00 - Préparations pour examen in vivo
• C07K 16/00 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux
• C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire

Abrégé

Biodegradable orthopedic implants and coatings for the implants are provided. The implant can include a Mg alloy and a coating, where the coating includes silk fibroin. The coating can be anticorrosive and can include a first layer comprising polydopamine and a second layer comprising silk fibroin. The silk fibroin can be combined with cellulose nanocrystals. Methods for making coated orthopedic implants are also provided.

Classes IPC  ?

• A61L 27/34 - Matériaux macromoléculaires
• A61L 27/04 - Métaux ou alliages
• A61L 27/58 - Matériaux au moins partiellement résorbables par le corps
• C09D 5/08 - Peintures anti-corrosion
• C09D 101/02 - CelluloseCellulose modifiée
• C09D 189/00 - Compositions de revêtement à base de protéinesCompositions de revêtement à base de leurs dérivés

Abrégé

The present disclosure provides compounds of Formula I that are inhibitors of histone methyltransferase polycomb repressive complex 2 (PRC2) and its subunits, including embryonic ectoderm development (BED) protein, and are therefore useful for the treatment of diseases treatable by inhibition of dysregulation of PRC2 and EED such as cancers. Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

Classes IPC  ?

• C07D 211/90 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
• C07D 213/80 - AcidesEsters en position 3
• A61K 31/4422 - 1,4-Dihydropyridines, p. ex. nifédipine, nicardipine
• A61K 31/4418 - Pyridines non condenséesLeurs dérivés hydrogénés ayant un carbocycle lié directement à l'hétérocycle, p. ex. cyproheptadine
• A61P 35/00 - Agents anticancéreux

Produits et services

Blueberries, fresh; Live plants, namely, blueberry; Fresh berries

Abrégé

Provided herein are microscopes providing multi-directional illumination of a sample volume by alternately reflecting a light sheet exiting a single objective lens off of multiple reflectors positioned about the sample volume. The provided microscopes exhibit high lateral and axial resolution and are particularly useful for imaging thick samples. Also provided are methods and computer instructions and systems for using the provided microscopes.

Classes IPC  ?

• G02B 21/06 - Moyens pour éclairer un échantillon
• G02B 21/04 - Objectifs comprenant des miroirs
• G02B 21/16 - Microscopes adaptés pour éclairage ultraviolet
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

Disclosed herein are disinfection inserts comprising a fiber optic and a polymer surrounding at least a portion of the fiber optic (and methods of making and using the same). The polymer comprises a NO donor molecule that releases NO upon illumination of the polymer by the fiber optic. The disinfection inserts can be inserted into tubing, catheters, and/or extracorporeal devices and illuminated to release NO from the polymer. The released NO inactivates pathogens on or within the tubing, catheter, and/or extracorporeal device. The disinfection insert can be configured for removable attachment to the tubing, catheter, and/or extracorporeal device, such that it can be periodically replaced. Furthermore, the disinfection insert can be placed in optical communication with a controllable light source. The controllable light source can be coupled to a light source controller. The intensity and wavelength of the light can be varied to change the flux of NO.

Classes IPC  ?

• A61L 2/26 - Accessoires
• A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
• A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
• A61M 25/00 - CathétersSondes creuses