Abrégé

The present invention relates to compositions comprising Pterostilbene, or a pharmaceutically acceptable salt thereof, in combination with Silibinin, or a pharmaceutically acceptable salt thereof, and their use in the treatment, prevention, amelioration or reduction of diseases induced by ionizing radiation in a subject. The compositions and the uses can further comprise at least one or more radiomitigator compound/s, preferably NAD+ boosters and/or FSL-1.

Classes IPC  ?

• A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
• A61K 8/34 - Alcools
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61K 31/09 - Éthers ou acétals ayant une liaison éther à un carbone cyclique d'un noyau aromatique ayant plusieurs liaisons éther
• A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
• A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
• A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
• A61Q 19/00 - Préparations pour les soins de la peau

Abrégé

The invention relates to inhibitors of MSI2 functions that are able to decrease MSI2 activity, MSI2 transcript levels or MSI2 protein levels in myotonic dystrophy cells or cells with MD phenotype, wherein said inhibitor is for use in the treatment of myotonic dystrophy in a mammal.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The invention relates to a device and method for microextracting compounds in samples, wherein the device comprises a support (1) that carries a power source, a microcontroller, an interface (3), which comprises a fixed supporting element (5) comprising an electromagnet (6), designed to support a container in which the sample to be extracted is disposed, and an arm (7) that holds a motor which, by means of a shaft, moves a rotary magnet (8) arranged on the electromagnet (6) and spaced therefrom. According to the invention, the method is based on agitating a magnetic sorbent inside the container by means of the rotation of the magnet (8) and retaining the sorbent by means of the electromagnet (6) to prevent the accidental loss thereof when the one or more solutions are removed from the container.

Classes IPC  ?

• B03C 1/12 - Séparation magnétique agissant directement sur la substance à séparer ayant des supports pour le matériau traité, de forme cylindrique avec des aimants se déplaçant pendant l'opérationSéparation magnétique agissant directement sur la substance à séparer ayant des supports pour le matériau traité, de forme cylindrique avec des pièces de pôle mobiles
• B03C 1/01 - Prétraitement spécialement adapté à la séparation magnétique par addition d'agents magnétiques
• B01D 11/04 - Extraction par solvants de solutions
• B01F 33/45 - Mélangeurs magnétiquesMélangeurs avec agitateurs à entraînement magnétique
• G01N 1/28 - Préparation d'échantillons pour l'analyse

Abrégé

121233 is a residue of two condensed rings, which has the meanings indicated in the description.

Classes IPC  ?

• C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• C07D 403/06 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée ne contenant que des atomes de carbone aliphatiques
• C07D 405/06 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• C07D 409/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• C07D 413/06 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
• C07D 471/04 - Systèmes condensés en ortho
• A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
• A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
• A61Q 19/00 - Préparations pour les soins de la peau

Abrégé

The present invention relates to a plant or plant cell that is genetically modified to overexpress a gene that codes for the D-3-phosphoglycerate dehydrogenase (PGDH1) protein, wherein PGDH1 comprises amino acids conserved between species and wherein said plant does not belong to the Arabidopsis thaliana species. The invention further relates to a method that comprises transforming wild plants or plant cells with a recombinant expression vector. The invention also relates to uses of the plant or plant cell for producing proteins, amino acids and/or starch.

Classes IPC  ?

• C12N 15/82 - Vecteurs ou systèmes d'expression spécialement adaptés aux hôtes eucaryotes pour cellules végétales

Abrégé

The invention relates to sulfated chitosan derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description, for their use in the treatment and/or prevention of a viral infection, particularly wherein the viral infection is caused by SARS-CoV-2 such as COVID-19 or RSV.

Classes IPC  ?

• A61K 31/737 - Polysaccharides sulfatés, p. ex. sulfate de chondroïtine, sulfate de dermatane
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• C08B 37/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés

Abrégé

The present invention relates to compounds, in particular conjugates and labelled derivatives of citrinin at a new position in the molecule, suitable for the production of antibodies with a high affinity for citrinin. The present invention also relates to the use of said citrinin conjugates and labelled derivatives of citrinin as test antigens. The invention also relates to the use of the compounds for the analysis, concentration and extraction of citrinin using the obtained antibodies, in sometimes together with test antigens that are conjugates or labelled derivatives. The invention also provides a kit for analysing citrinin comprising antibodies against said mycotoxin, sometimes together with test antigens that are conjugates or labelled derivatives of citrinin.

Classes IPC  ?

• C07D 311/76 - Benzo [c] pyrannes
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/532 - Production de composés immunochimiques marqués
• C07K 16/14 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de champignons, d'algues ou de lichens
• B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale

Abrégé

The present invention relates to a device for channelling blood for haemodialysis comprising a bypass valve (2), with two vascular connection ducts (3, 4), and a connection (5) to a dialyser. The valve (2) comprises an inner selector (6) for selecting two positions and an antiseptic tank (7) placed in the connection (5) to a dialyser, as well as biointegration means.

Classes IPC  ?

• A61M 39/22 - Soupapes ou agencement de soupapes
• A61M 60/37 - Hémodialyse, hémofiltration ou diafiltration
• A61M 60/851 - Vannes

Abrégé

A 2D bismuth material, also called bismuthene, has a sandwich-like sheet structure with at least two outer layers formed by organic molecules containing sulphur atoms that form Bi—S bonds and at least one inner layer formed by a crystalline network of Bi(0) atoms. These materials are useful in electronic, optoelectronic, catalytic applications or in energy storage and transformation. Furthermore, a process produces this material from a bismuth salt that reacts with an amine and subsequently with a thiol by effect of the application of radiation and a subsequent reduction. This process has a colloidal approach to producing Bi(0) crystals based on a photocatalytic reduction of a soluble Bi(III) organometallic complex leading to the generation of the crystals.

Classes IPC  ?

• C01G 29/00 - Composés du bismuth

Abrégé

The present invention relates to the use of the spin-transition molecular compound [iron(II) (hydrotris(3,5-dimethyl-1-pyrazolyl)borate)2] as a temperature detector by measuring a colour change in the molecular compound; to a temperature sensor comprising the compound, provided in the form of a film; and to a temperature detection system comprising the sensor and an optical detector.

Classes IPC  ?

• G01K 11/12 - Mesure de la température basée sur les variations physiques ou chimiques, n'entrant pas dans les groupes , , ou utilisant le changement de couleur, de translucidité ou de réflectance

Abrégé

The present invention relates to hybrid materials comprising: upconversion nanoparticles and inorganic halide perovskite nanoparticles arranged within tube-shaped lead, tin or a mixture thereof salt nanoclusters. The invention also relates to a preparation method for preparing said hybrid material, and to the use of the hybrid material in the photovoltaic industry.

Classes IPC  ?

• C09K 11/02 - Emploi de substances particulières comme liants, revêtements de particules ou milieux de suspension
• C09K 11/66 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant du germanium, de l'étain ou du plomb
• C09K 11/85 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant des métaux des terres rares contenant des halogènes
• H01L 31/055 - Dispositifs à semi-conducteurs sensibles aux rayons infrarouges, à la lumière, au rayonnement électromagnétique d'ondes plus courtes, ou au rayonnement corpusculaire, et spécialement adaptés, soit comme convertisseurs de l'énergie dudit rayonnement e; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de ces dispositifs ou de leurs parties constitutives; Leurs détails adaptés comme dispositifs de conversion photovoltaïque [PV] Éléments optiques directement associés ou intégrés à la cellule PV, p.ex. moyens réflecteurs ou concentrateurs de lumière où la lumière est absorbée et réémise avec une longueur d’onde différente par l’élément optique directement associé ou intégré à la cellule PV, p.ex. en utilisant un matériau luminescent, des concentrateurs fluorescents ou des dispositions de convers

Abrégé

The invention relates to a heterobimetallic dimer catalyst stabilised by thioether residues of the methylcysteine of a metal–organic framework (MOF) and represented as X1-Y1-MOF, which has the general chemical formula: X1-Y1@{MIICuII 6[(S,S)–Mecysmox]3(OH)2(H2O)}. nH2O, where: - X and Y are metals, where X is different from Y; - X is selected from Pd, Pt and Ni; - Y is selected from Pd, Fe, Ni, Cu, Co, Au, Pt, Sn, Rh and Ag; - Mecysmox means bis[S-methylcysteine]oxalyl diamide; - M is selected from Ca, Sr and Ba; and - n = 0-20, both values inclusive. The invention further relates to the use thereof in hydrogenation reactions, particularly in acetylene semi-hydrogenation.

Classes IPC  ?

• B01J 23/42 - Platine
• B01J 23/44 - Palladium
• B01J 23/50 - Argent
• B01J 23/52 - Or
• B01J 31/22 - Complexes organiques

Abrégé

T211. The invention also relates to a microscope comprising the accessory and a method for obtaining a focal image.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

The present invention relates to a method and a corresponding device for recovering water and eliminating nitrate ions in aqueous currents, based on denitrification by means of electrochemical reduction. The method allows nitrate ions to be converted into N2 gas and the majority of the treated water to be recovered as low-mineralised water, which helps minimise the environmental impact associated with the discharge of generated wastewater. Advantageously, the invention allows some of the ions in the treated water to be converted into recoverable insoluble salts, while other ions are managed as concentrated solutions useful in steps of the method. The invention also allows the gas mixture obtained in one of the steps of the method to be used to supply a fuel cell, thereby reducing energy costs and helping minimise fossil fuel use in the process.

Classes IPC  ?

• C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
• C02F 1/467 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse par désinfection électrochimique
• C02F 9/00 - Traitement en plusieurs étapes de l'eau, des eaux résiduaires ou des eaux d'égout
• C02F 1/42 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par échange d'ions
• C02F 1/44 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par dialyse, osmose ou osmose inverse
• C02F 101/16 - Composés de l'azote, p. ex. ammoniac

Abrégé

The present invention relates to the chemical synthesis and production of compounds derived from imidazo[1,2-a]pyridine of formula I, wherein R2, R3, R5, R6and R7 have the meanings indicated in the description; a method for obtaining same; and the therapeutic use thereof as a pharmaceutical composition for anti-inflammatory use in vitro and in vivo in diseases involving inflammatory and pro-fibrotic processes.

Classes IPC  ?

• C07D 471/04 - Systèmes condensés en ortho
• A61K 31/437 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à cinq chaînons ayant l'azote comme hétéro-atome du cycle, p. ex. indolizine, bêta-carboline
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]

Abrégé

Provided is a method for preparing layers of non-stoichiometric palladium oxide, which comprises the steps of: dissolving a palladium (II) salt in a polar or apolar solvent; ageing the solution in a thermostatic bath or dry block at 30-70°C for at least 10 minutes, agitating the solution; depositing the aged solution on a substrate to form a wet layer; and curing the wet layer by means of thermal or UV curing. A layer of non-stoichiometric palladium oxide and the use of same in photovoltaic, optoelectronic or catalytic applications of as sensors, are also provided.

Classes IPC  ?

• C23C 18/00 - Revêtement chimique par décomposition soit de composés liquides, soit de solutions des composés constituant le revêtement, ne laissant pas de produits de réaction du matériau de la surface dans le revêtementDépôt par contact
• C01G 1/02 - Oxydes
• C01G 55/00 - Composés du ruthénium, du rhodium, du palladium, de l'osmium, de l'iridium, ou du platine
• H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives

Abrégé

Haloperidol, or a pharmaceutically acceptable salt, ester or solvate thereof, as well as pharmaceutical compositions comprising the same, for use in methods for preventing and/or treating spinal muscular atrophy, are described.

Classes IPC  ?

• A61K 31/4515 - Pipéridines non condensées, p. ex. pipérocaïne ayant un groupe butyrophénone en position 1, p. ex. halopéridol
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire

Abrégé

The invention relates to a device for measuring electrical current by means of non-dissipative galvanic isolation, with offset adjustment and current polarisation by means of a triple voltage-to-current converter. Said device comprises: a first sensor subsystem that comprises at least one magneto resistor configured as a sensor element configured to provide galvanic isolation with respect to an electrical current to be measured; a second subsystem that comprises a resistor through which flows a current based on the value of gain and a control voltage; a third subsystem that comprises an offset adjustment resistor through which flows the current determined in the second subsystem, which makes it possible to compensate for a possible imbalance in the sensor element with zero electrical current; and a fourth subsystem formed by a processor that provides a voltage signal proportional to the electrical current to be measured.

Classes IPC  ?

• G01R 19/00 - Dispositions pour procéder aux mesures de courant ou de tension ou pour en indiquer l'existence ou le signe
• G01R 15/18 - Adaptations fournissant une isolation en tension ou en courant, p. ex. adaptations pour les réseaux à haute tension ou à courant fort utilisant des dispositifs inductifs, p. ex. des transformateurs
• G01R 33/09 - Mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques en utilisant des dispositifs galvano-magnétiques des dispositifs magnéto-résistifs
• G01R 15/20 - Adaptations fournissant une isolation en tension ou en courant, p. ex. adaptations pour les réseaux à haute tension ou à courant fort utilisant des dispositifs galvano-magnétiques, p. ex. des dispositifs à effet Hall

Abrégé

A pump system for a high-power holmium-doped fiber optic laser is provided, comprising: a 1.13 micron pumping means composed of: a coreless fiber and a light absorber; high and low reflection Bragg gratings at 1.135 microns, which form a ytterbium fiber laser cavity; high-power 915 nm laser diodes pumping the ytterbium fiber; and a high reflection Bragg grating (HR-FBG) at 2.07 microns; and a 2 micron laser formed by a holmium-doped fiber (HDF) that forms, with the high reflection Bragg grating at 2.07 microns, a holmium-doped fiber laser cavity, where each 915 nm photon of the 915 nm laser diodes that is converted into a 1.13 micron photon releases additional energy in the form of heat.

Classes IPC  ?

• H01S 3/0941 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p. ex. par une diode laser
• H01S 3/04 - Dispositions pour la gestion thermique
• H01S 3/067 - Lasers à fibre optique
• H01S 3/094 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente
• H01S 3/16 - Matériaux solides

Abrégé

The present invention relates to a method for measuring the levels of Protein C (PROC), preferably Activated Protein C (APC), in a subject in need thereof, the method comprising a step of performing an enzymatic digestion of one or more biological samples isolated from the subject, and a step of measuring the levels of the peptide of SEQ ID NO 1 (LGEYDLR) and/or SEQ ID NO 2 (TFVL-NFIK), wherein the levels of SEQ ID NO 1 and/or SEQ ID NO 2 correspond to the levels of PROC, preferably APC, present in said one or more biological samples. Methods for classifying subjects and prognosticating the response to treatments are also included.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61P 31/00 - Agents anti-infectieux, c.-à-d. antibiotiques, antiseptiques, chimiothérapeutiques
• G01N 1/40 - Concentration des échantillons

Abrégé

The invention relates to a device for carrying out chemical reactions. The device comprises a rotating platform configured to rotate about a central axis thereof, wherein the rotating platform comprises a plurality of first receiving elements for each receiving a container; and a plurality of agitation mechanisms. Each agitation mechanism of the plurality of agitation mechanisms is arranged on or below each retaining element to magnetically agitate the corresponding container from below. The device also comprises a support for a light source, with said support being fixedly arranged on the device, so that when the light source is fixed on the support, the light is radiated towards the rotating platform, laterally falling on each container as it passes in front of the support.

Classes IPC  ?

• B01J 19/28 - Réacteurs mobiles, p. ex. tambours rotatifs
• B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
• B01F 29/321 - Éprouvettes ou similaires

Abrégé

The invention relates to an electrocatalytic electrode comprising a coating film on an electrically conductive base substrate that includes a non-stoichiometric mixed oxide dispersed in the film, including a mixture of iron and vanadium, in a metal-organic matrix, the organic part of which includes the mixed oxide dispersed therein. The electrocatalytic electrode can be used for the production of molecular hydrogen. The invention also relates to a method for obtaining the electrocatalytic electrode and the use of the electrocatalytic electrode for the improved production of molecular hydrogen by means of at least hydrolysis of water, alkaline electrolysis of water, alkaline electrolysis via ion exchange, as a selective electrode and as an electrode for the oxidation of organic compounds in an aqueous solution.

Classes IPC  ?

• H01M 4/52 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer
• B01J 23/847 - Vanadium, niobium ou tantale
• B01J 37/02 - Imprégnation, revêtement ou précipitation
• C25B 11/091 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques
• C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau

Abrégé

A biosensor and virusometer allows continuous, real-time detection of viral particles of pathogens, especially SARS-COV-2, both in indoor and outdoor air and in liquid samples in which the pathogen(s) have been collected. The biosensor includes a quartz crystal microbalance coated with a layer having one or more antibodies specific to one or more pathogens to be detected. A first virusometer is described, including an aerosol collector, which makes it possible to increase the concentration of pathogens before taking them to the biosensor. A second virusometer has a receptacle, divided into a first cavity wherein air exhaled by a user is collected and concentrated, and a second cavity wherein the biosensor is arranged.

Classes IPC  ?

• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• G01G 3/13 - Appareils de pesée caractérisés par l'utilisation d'organes déformables par élasticité, p. ex. balances à ressort dans lesquels l'élément de pesée est constitué par un corps solide soumis à une pression ou une traction pendant la pesée le corps solide présentant des propriétés piézo-électriques ou piézo-résistives
• G01G 3/16 - Appareils de pesée caractérisés par l'utilisation d'organes déformables par élasticité, p. ex. balances à ressort dans lesquels l'élément de pesée est constitué par un corps solide soumis à une pression ou une traction pendant la pesée utilisant la mesure des variations de la fréquence des oscillations du corps
• G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
• G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques
• G01N 33/497 - Analyse physique de matériau biologique de matériau biologique gazeux, p. ex. de l'haleine

Abrégé

The present invention relates to novel differentially methylated genetic elements associated with cutaneous Spitzoid tumors. The invention also relates to improved methods for classifying said tumors.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a method for synthesising mesoporous silica nano-rods with a cylindrical inner pore, one per nano-rod and able to contain a material, where the method comprises: a) mixing multiwalled carbon nanotubes having diameters between 4 nm and 80 nm with a tetraalkylammonium salt; b) grinding the mixture of step a) in a ball mill; c) - preparing an atrane selected from: silicon atrane with ligands derived from an aminotrialcohol or silicon atrane and another metal or metalloid with ligands derived from an aminotrialcohol; and d) adding the mixture obtained in step b) to the atrane obtained in step c), letting it cool, adding a mixture of water and alcohol, and letting it age, where ageing obtains mesoporous silica nano-rods as a precursor product.

Classes IPC  ?

• B82Y 40/00 - Fabrication ou traitement des nanostructures
• C01B 33/12 - SiliceSes hydrates, p. ex. acide silicique lépidoïque

Abrégé

The invention relates to compounds, in particular conjugates and labelled derivatives of zearalenone at a new position in the molecule, suitable for the production of antibodies with a high affinity for zearalenone. The invention also relates to the use of said zearalenone conjugates and labelled derivatives of zearalenone as test antigens. The invention also relates to the use of the compounds for the analysis, concentration and extraction of zearalenone using the obtained antibodies, sometimes together with test antigens that are conjugates or labelled derivatives. The invention also provides a kit for analysing zearalenone comprising antibodies against said mycotoxin, sometimes together with test antigens that are conjugates or labelled derivatives of zearalenone.

Classes IPC  ?

• C07D 313/00 - Composés hétérocycliques contenant des cycles de plus de six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• G01N 33/532 - Production de composés immunochimiques marqués
• C07K 16/14 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant de champignons, d'algues ou de lichens
• B01D 15/38 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction spécifique non couverte par un ou plusieurs des groupes , p. ex. chromatographie d'affinité, chromatographie d'échange par ligand ou chromatographie chirale

Abrégé

The present invention relates to a method for obtaining stilbenes that comprises adding cyclodextrins and methyl jasmonate to a cell culture medium of a plant of the genus Morus that are capable of synthesising said stilbenes and promoting the extracellular accumulation of same.

Classes IPC  ?

• C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
• C12N 5/04 - Cellules ou tissus végétaux
• C12P 7/22 - Préparation de composés organiques contenant de l'oxygène contenant un groupe hydroxyle aromatiques

Abrégé

The present invention relates to a photocatalyst nanomaterial comprising a solid substrate and a metal oxide/oxyhydroxide arranged on the solid substrate forming a coating having a thickness comprised between 1 nm and 1 micrometer and having an amorphous structure. The invention also relates to a nanometric coating which comprises the described photocatalyst material and metallic nanoparticles, as well as to the method for obtaining the catalyst material, to the use of the catalyst material as a photocatalyst in the ultrafast synthesis of metallic nanoparticles, and to the use of the nanometric coating in the manufacture of optical sensors, biocidal coatings and elimination of reactive oxygen species.

Classes IPC  ?

• B01J 35/39 - Propriétés photocatalytiques
• B01J 21/06 - Silicium, titane, zirconium ou hafniumLeurs oxydes ou hydroxydes
• B01J 35/30 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général caractérisés par leurs propriétés physiques
• B01J 35/45 - Nanoparticules
• B01J 37/02 - Imprégnation, revêtement ou précipitation
• B01J 37/34 - Irradiation ou application d'énergie électrique, magnétique ou ondulatoire, p. ex. d'ondes ultrasonores

Abrégé

An apparatus (1) for treating a cancerous target site is provided. The apparatus comprises an electromagnetic emitter (10) comprising one or more electrodes with an electrically insulating coating for preventing electrical contact between the electrodes and the target site. The electromagnetic emitter (10) is configured to provide a tumour treating field at a target site (30) via the one or more electrodes, the tumour treating field being non-ionizing alternating electromagnetic field having a frequency of between 10 kHz to 300 kHz; and further having a magnetic flux density of between 0.1 pT and 1 mT. The apparatus further comprises a heat source (20) configured to provide heating at the target site to cause hyperthermia at the target site. The apparatus is configured to apply the non-ionizing alternating electromagnetic field and the heating independently. The apparatus comprises an electronic controller for electronically controlling the electromagnetic emitter and the heat source.

Classes IPC  ?

• A61N 2/00 - Magnétothérapie
• A61F 7/02 - Compresses ou cataplasmes procurant de la chaleur ou du froid
• A61N 2/02 - Magnétothérapie utilisant des champs magnétiques produits par des bobines, y compris par des boucles à spire unique ou par des électro-aimants
• A61N 7/02 - Hyperthermie localisée par ultrasons

Abrégé

The present invention relates to the use of BODIPY-derived compounds to detect drugs such as scopolamine, ketamine and cathinones. When the chromophore BODIPY is combined with copper salts, its colour and fluorescence change in the presence of these drugs. The invention also relates to a kit for detecting these drugs, which includes the BODIPY-derived compounds.

Classes IPC  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
• G01N 31/22 - Utilisation des réactifs chimiques
• G01N 33/14 - Boissons
• G01N 33/52 - Utilisation de composés ou de compositions pour des recherches colorimétriques, spectrophotométriques ou fluorométriques, p. ex. utilisation de bandes de papier indicateur
• C07F 5/02 - Composés du bore

Abrégé

The present invention relates to a layered double hydroxide comprising at least one divalent cation AII or alternatively LiI, at least one trivalent cation BIII selected from the group consisting of VIII, CoIII, CrIII, MnIII FeIII, GaIII and lanthanides. The present invention also relates to a process for the synthesis of said layered double hydroxide and uses thereof.

Classes IPC  ?

• C01G 53/00 - Composés du nickel
• C25B 11/042 - Électrodes à base d’un seul matériau
• H01M 4/36 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs
• H01M 4/525 - Emploi de substances spécifiées comme matériaux actifs, masses actives, liquides actifs d'oxydes ou d'hydroxydes inorganiques de nickel, de cobalt ou de fer d'oxydes ou d'hydroxydes mixtes contenant du fer, du cobalt ou du nickel pour insérer ou intercaler des métaux légers, p. ex. LiNiO2, LiCoO2 ou LiCoOxFy

Abrégé

The present invention refers to the use of specific metabolites for assessing the activity of NNMT, for selecting patients which may benefit from a treatment with NNMT inhibitors, for the prognosis and/or predicting the response of patients to NNMT inhibitors, for predicting whether a patient is resistant to a treatment with tyrosine kinase inhibitors and/or for screening NNMT inhibitor candidates.

Classes IPC  ?

• C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
• G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
• G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer

Abrégé

The present invention relates to compounds, especially to conjugates and derivatives of alternariol labelled at specific positions in the molecule, suitable for the production of antibodies with a high affinity for alternariol. Likewise, the present invention also relates to the use of said alternariol conjugates and labelled alternariol derivatives as test antigens. The present invention also relates to methods for the analysis, concentration and extraction of alternariol using the antibodies obtained, together with test antigens that are conjugates or labelled derivatives. This invention also provides a kit for analysing alternariol comprising antibodies against said mycotoxin, in certain cases together with test antigens that are conjugates or labelled alternariol derivatives.

Classes IPC  ?

• C07D 311/80 - DibenzopyrannesDibenzopyrannes hydrogénés
• C07K 1/113 - Procédés généraux de préparation de peptides par modification chimique de peptides précurseurs sans changement de la structure primaire
• C07K 14/77 - Ovalbumine
• C07K 14/765 - Sérum albumine, p. ex. HSA
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet

Abrégé

The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure. The invention also relates to methods for obtaining them with high yields, in addition to their uses in the generation of solar fuels, photoactivated degradation, photoreduction of CO2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.

Classes IPC  ?

• C07F 7/28 - Composés du titane
• C07F 1/08 - Composés du cuivre

Abrégé

R from the field diaphragm (5).

Classes IPC  ?

• H04N 7/18 - Systèmes de télévision en circuit fermé [CCTV], c.-à-d. systèmes dans lesquels le signal vidéo n'est pas diffusé
• G02B 3/00 - Lentilles simples ou composées
• G02B 27/10 - Systèmes divisant ou combinant des faisceaux
• G06T 7/50 - Récupération de la profondeur ou de la forme

Abrégé

The invention provides oligonucleotide and/or oligonucleotide analogue molecules that are antagonists of a microRNA, preferably antagonists of human microRNAs hsa-miR-23b-3p and hsa-miR-218-5p, that comprise a mixture of phosphorothioate and phosphodiester linkages, and that are conjugated to at least one oleic acid molecule. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2. The present invention further provides compositions comprising said oligonucleotides and/or oligonucleotide analogue molecules and their uses for the treatment and prevention of DM in a subject in need thereof.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire

Abrégé

The present invention relates to a method for producing improved strains of Saccharomyces cerevisiae with optimised wine-making properties, which comprises preparing at least one culture, wherein an initial strain of S. cerevisiae is in contact with at least 10 mg/l of 2-aminoethyl-L-cysteine in a culture medium and is grown for at least five weeks; and isolating individual mutants of the S. cerevisiae strain with optimised wine-making properties once that time has elapsed. The invention also relates to improved strains obtained using the method and to uses of same in the alcoholic fermentation of vegetable substrates.

Classes IPC  ?

• C12N 1/18 - Levure de boulangerieLevure de bière
• C12N 1/38 - Stimulation chimique de la croissance ou de l'activité par addition de composés chimiques qui ne sont pas des facteurs essentiels de croissanceStimulation de la croissance par élimination d'un composé chimique
• C12N 15/01 - Préparation de mutants sans introduction de matériel génétique étrangerProcédés de criblage à cet effet
• C12G 1/02 - Préparation du moût à partir du raisinTraitement ou fermentation du moût
• C12G 3/02 - Préparation d'autres boissons alcoolisées par fermentation
• C12R 1/865 - Saccharomyces cerevisiae

Abrégé

The invention provides oligonucleotide and/or oligonucleotide analogue molecules that are antagonists of a microRNA, preferably antagonists of human microRNAs hsa-miR-23b-3p and hsa-miR-218-5p, that comprise a mixture of phosphorothioate and phosphodiester linkages, and that are conjugated to at least one oleic acid molecule. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2. The present invention further provides compositions comprising said oligonucleotides and/or oligonucleotide analogue molecules and their uses for the treatment and prevention of DM in a subject in need thereof.

Classes IPC  ?

• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens

Abrégé

The present invention relates to a process for obtaining perovskite thin films from powders of inorganic and organic materials by vapour deposition, characterized in that the crucible used to heat the powders is pre-heated above their sublimation temperature and in that this powder is fed in µg/pulse quantities to the pre-heated crucible by a feeder system. Furthermore, the invention is related to a device to carry out this process.

Classes IPC  ?

• C23C 14/24 - Évaporation sous vide

Abrégé

Use of simple acyclic polyamines for the treatment of parasites of the family Trypanosomatidae Use of simple acyclic polyamines for the treatment of parasites of the family Trypanosomatidae The present invention provides the use of certain single acyclic polyamines of Formula (I), attached to heterocycles, for the treatment of leishmaniasis and trypanosomiasis. All the compounds studied show antiparasitic activity against Leishmania species, comparable or superior to that of the active ingredient of the drug commonly used to treat this disease, but with a macrophage toxicity similar to or, in most cases, lower than that of the commercial reference compound, and with higher selectivity indices against strains representative of the three clinical forms of the disease: cutaneous, mucocutaneous and visceral. The compounds show ability to inhibit parasite superoxide dismutase, generally at concentrations lower than those required to inhibit human superoxide dismutase. All this supports its usefulness for treating leishmaniasis and also trypanosomiasis.

Classes IPC  ?

• A61K 31/4406 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 3, p. ex. zimeldine
• A61K 31/4409 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 4, p. ex. isoniazide, iproniazide
• A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
• A61K 31/47 - QuinoléinesIsoquinoléines
• A61K 31/4402 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 2, p. ex. phéniramine, bisacodyl
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

The present invention relates to the in vitro use of ethinylestradiol to increase the growth of lipid-enveloped viruses, in particular SARS-CoV-2 and influenza A virus (IAV). The invention also relates to a method for increasing the in vitro growth of a lipid-enveloped virus. The method comprises infecting a cell or cell line with the virus and incubating the infected cell or cell line with a culture medium comprising ethinylestradiol. Consequently, the use of ethinylestradiol can improve yields in the production of these viruses and reduce the production costs associated with, for example, vaccine production.

Classes IPC  ?

• C12N 7/02 - Isolement ou purification
• C07J 1/00 - Stéroïdes normaux contenant du carbone, de l'hydrogène, un halogène ou de l'oxygène, non substitués en position 17bêta par un atome de carbone, p. ex. œstrane, androstane

Abrégé

in vitro in vitro in vitro specific viral sequence detection, including without limitation to, SARS-CoV-2 detection, based on the use of a CRISPR-Cas9 system.

Classes IPC  ?

• C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
• C12N 9/22 - Ribonucléases
• C12Q 1/6818 - Tests d’hybridation caractérisés par les moyens de détection impliquant l’interaction de plusieurs marqueurs, p. ex. transfert d’énergie de résonance
• C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique

Abrégé

Disclosed are antagonists of human micro RNA miR-100, miR-20, miR-222, miR-181 and miR-92 and uses of same. The invention provides inhibitors of human micro-RNA miR-100, miR-20a, miR-222, miR-181c and miR-92a, which are repressors of the genes MBNL1 and/or MBNL2. The use of the inhibitors as a drug, in particular against myotonic dystrophy type 1, is also provided.

Classes IPC  ?

• A61K 31/7115 - Acides nucléiques ou oligonucléotides ayant des bases modifiées, c.-à-d. autres que l'adénine, la guanine, la cytosine, l'uracile ou la thymine
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire

Abrégé

The present invention relates to compound 1 or 2 or the composition comprising it. The present invention also relates to a process for obtaining compound 1 or 2, as well as to the use thereof for detecting GHB in beverages. An equipment or kit for use in detecting GHB in beverages is also included.

Classes IPC  ?

• G01N 33/14 - Boissons
• C07C 335/16 - Dérivés de thiourée ayant des atomes d'azote de groupes thiourée liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné

Abrégé

A method for obtaining bimodal mesoporous materials based on silicon oxides by using microwave radiation. A method for obtaining bimodal mesoporous materials, based on silicon oxides, from atranic precursors, characterized in that it comprises: —a first step of forming a mesostructured material containing organic matter, —and a second step of eliminating the organic matter contained in the mesostructured material, by calcination, obtaining a bimodal mesoporous material based on silicon oxide, such that at least one of the two steps is carried out by irradiation of the corresponding starting material, with microwave radiation from solid state sources.

Classes IPC  ?

• C01B 33/113 - Oxydes de siliciumLeurs hydrates
• B01J 6/00 - CalcinationCuisson

Abrégé

A mechanical collimator receives particles from a gamma radiation emission source and/or neutron emission source, a material that absorbs neutrons and is virtually transparent to gamma radiation A first detector includes a scintillator crystal with neutron-gamma discrimination capability and a position-sensitive photosensor, coupled to the mechanical collimator. One or more detector blocks have scintillator crystals of gamma or neutron-gamma radiation and position-sensitive photosensors, after the first detector, on a face opposite the mechanical collimator. A processing and acquisition module is connected to the detectors The device is suitable for use in inspections relating to nuclear safety, port safety, nuclear threats and accidents, and hadron-therapy treatments and nuclear medicine.

Classes IPC  ?

• G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
• G01J 5/08 - Dispositions optiques
• G01T 1/16 - Mesure de l'intensité de radiation
• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G01T 1/202 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant du cristal
• G01T 1/24 - Mesure de l'intensité de radiation avec des détecteurs à semi-conducteurs

Abrégé

The present invention relates to compound 1 or 2 or the composition comprising it. The present invention also relates to a process for obtaining compound 1 or 2, as well as to the use thereof for detecting GHB in beverages and urine. An equipment or kit for use in detecting GHB in beverages and urine is also included.

Classes IPC  ?

• C07D 263/60 - NaphtoxazolesNaphtoxazoles hydrogénés
• C07D 493/10 - Systèmes condensés en spiro
• G01N 33/94 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des narcotiques
• G01N 33/14 - Boissons
• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur

Abrégé

The invention relates to sulfated chitosan derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description, for their use in the treatment and/or prevention of a viral infection, particularly wherein the viral infection is caused by SARS-CoV-2 such as COVID-19 or RSV.

Classes IPC  ?

• C08B 37/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
• A61K 31/722 - ChitineChitosane

Abrégé

The present invention relates to a disinfection system, which comprises a mobile disinfection robot (R) with: - a disinfection unit (L) for emitting disinfectant light towards the space surrounding the robot (R); - detection means for detecting the value of a detection parameter relating to the light intensity of the elements to be disinfected, which comprise processing means that implement a radiosity shading algorithm for determining shaded areas, based on processing the detected values; and - control means connected to the detection means for receiving the detected values of the detection parameter, and to the disinfection unit (L) for controlling its operation according to operating parameters that can be adjusted based on the detected values. The present invention further relates to a disinfection method suitable for using the system of the invention.

Classes IPC  ?

• A61L 2/10 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations des ultraviolets
• A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
• B25J 11/00 - Manipulateurs non prévus ailleurs

Abrégé

Haloperidol, or a pharmaceutically acceptable salt, ester or solvate thereof, as well as pharmaceutical compositions comprising the same, for use in methods for preventing and/or treating spinal muscular atrophy, are described.

Classes IPC  ?

• A61K 31/4515 - Pipéridines non condensées, p. ex. pipérocaïne ayant un groupe butyrophénone en position 1, p. ex. halopéridol
• A61K 31/4709 - Quinoléines non condensées contenant d'autres hétérocycles
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
• A61K 31/7125 - Acides nucléiques ou oligonucléotides ayant des liaisons internucléosides modifiées, c.-à-d. autres que des liaisons 3'-5' phosphodiester
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester

Abrégé

The present invention relates to bioconjugates and labeled derivatives of the adducts formed by the reaction of patulin with benzene-1,2-dithiols or their salts. Said conjugates are suitable for the production of antibodies capable of recognizing the aforementioned patulin-(benzene-1,2-dithiols) adducts with high affinity and specificity. Likewise, the present invention also relates to the use of bioconjugates of patulin-(benzene-1,2-dithiols) adducts and of labeled derivatives thereof as assay antigens. Furthermore, the present invention also relates to immunochemical methods for the analysis of patulin, using the bioconjugates and labeled derivatives and antibodies of the invention, which include a previous step to quantitatively convert patulin into these adducts. This invention also provides a kit for analyzing patulin comprising a benzene-1,2-dithiol or its salts, antibodies against patulin-(benzene-1,2-dithiols) adducts, and assay antigens.

Classes IPC  ?

• C07D 339/08 - Cycles à six chaînons
• C07K 16/44 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs
• G01N 33/02 - Nourriture

Abrégé

The invention relates to an in vitro method for early detection, diagnosis, prognosis and/or monitoring of POAG in a patient, characterised by comprising the following steps: carrying out a metabolomic analysis of a biological sample obtained from a patient via high-field NMR spectroscopy, and processing the spectrum obtained to obtain a result that indicates whether the patient is positive or negative for POAG.

Classes IPC  ?

• G01N 33/487 - Analyse physique de matériau biologique de matériau biologique liquide

Abrégé

The invention relates to new tri-substituted tetrahydrofurans of formula (I) and their use as antiviral agent in the treatment and/or prevention of coronavirus infections and more particularly SARS-CoV-2 infection.

Classes IPC  ?

• C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
• A61P 31/12 - Antiviraux

Abrégé

The present invention relates to a pumping system for a high-power holmium-doped optic fibre laser, said system comprising: a 1.13 micron pumping means made up of a core-free fibre and a light absorber; Bragg gratings with high and low reflectivity at 1.135 microns that form a ytterbium fibre laser cavity; high-power 915 nm laser diodes that pump the ytterbium fibre; a high-reflectivity Bragg grating (HR-FBG) at 2.07 microns; and a 2 micron laser formed by a holmium-doped fibre (HDF) that forms, with the high-reflectivity Bragg grating at 2.07 microns, a holmium-doped fibre laser cavity, wherein each 915 nm photon of the 915 nm laser diodes that is turned into a 1.13 micron photon releases additional energy in the form of heat.

Classes IPC  ?

• H01S 3/067 - Lasers à fibre optique
• H01S 3/16 - Matériaux solides
• H01S 3/0941 - Procédés ou appareils pour l'excitation, p. ex. pompage utilisant le pompage optique par de la lumière cohérente produite par un laser à semi-conducteur, p. ex. par une diode laser

Abrégé

The titanium (IV) and iron (III) MOF solid MUV-17 (TiFe2), has general formula (1): [TiIVFeIII2(O)(L)2(X)3]S, where X is each equal or different selected from: O2−, OH−, H2O, F−, Cl−, Br−, I−, NO3−, ClO4−, BF4−, SCN−, OH−, CH3COO−, C5H7O2−, SO42− and CO32−, L is a tricarboxylic ligand and S is at least one molecule of a polar solvent selected from the group consisting of N,N′-dimethylformamide,N,N′-diethylformamide,N,N′-dimethylacetamide, N-methyl-2-pyrrolidone, methanol, ethanol, isopropanol, n-propanol, water and mixtures thereof. The titanium (IV) and iron (III) MOF solid has long-term catalytic activity for the degradation of toxic compounds. The method for obtaining them comprises dissolving the components under anaerobic conditions. The invention also relates to the use of the titanium (IV) and iron (III) MOF solid as an additive with detoxifying properties of toxic compounds.

Classes IPC  ?

• C07F 15/02 - Composés du fer
• A62D 3/35 - Procédés pour rendre les substances chimiques nuisibles inoffensives ou moins nuisibles en effectuant un changement chimique dans les substances par réaction avec des agents chimiques par hydrolyse
• B01J 31/16 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination

Abrégé

The present invention relates to a bacteriophage, the genome of which is nucleotide sequence SEQ_ID No: 1 or a sequence having at least 85% identity with same, for therapeutic use, more specifically for cognitive disorders; for example, of the executive functions or the memory. The bacteriophage can be administered as a pharmaceutical composition, a faecal preparation and/or a food composition.

Classes IPC  ?

• A61K 35/76 - VirusParticules sous-viralesBactériophages

Abrégé

The present invention relates to 2D bismuth material, also called bismuthene, with a sandwich-type laminar structure having at least two exterior layers formed by organic molecules containing sulfur atoms that form Bi-S bonds, and at least one interior layer formed by a crystalline lattice of Bi(0) atoms. These materials are suitable for use in electronic, optoelectronic and catalytic applications or in energy storage and conversion. The invention also relates to a method for obtaining the material from a bismuth salt, which reacts with an amine and subsequently with a thiol under the effect of the application of radiation and subsequent reduction. The method uses a colloidal approach to obtain Bi(0) crystals, which is based on photocatalytic reduction of a soluble Bi(III) organometallic complex that leads to the generation of said crystals.

Classes IPC  ?

• C22B 30/06 - Obtention du bismuth
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• B82Y 40/00 - Fabrication ou traitement des nanostructures

Abrégé

The present invention relates to C2-thioether tryptophan (Trp) trimers and tetramers in which differently substituted thio aryl rings have been introduced at the C2 position of the indole ring of each T rp moiety. The invention also refers to their therapeutic use for the treatment or prevention of betacoronoavirus infections, mainly against SARS- CoV-2 infection.

Classes IPC  ?

• C07D 209/30 - IndolesIndoles hydrogénés avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone de l'hétérocycle
• A61P 31/12 - Antiviraux
• A61K 31/404 - Indoles, p. ex. pindolol

Abrégé

The present invention relates to a composition containing an enzyme belonging to the group of superoxide dismutases (SOD), or any SOD mimic and similar, together with hyaluronic acid and EDTA. Said composition forms part of a pharmaceutical formulation which promotes or maintains eye health by inhibiting cellular and tissue damage caused by free radicals, making it useful in the treatment and/or prevention of eye diseases involving oxidative stress, or as an adjuvant to other existing treatments, as well as in post-operative treatments to treat and/or prevent oxidative stress or inflammatory adverse reactions.

Classes IPC  ?

• A61K 38/44 - Oxydoréductases (1)
• A61K 31/728 - Acide hyaluronique
• A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
• A61P 27/02 - Agents ophtalmiques

Abrégé

The present invention provides a method for producing metal halide perovskite nanocrystal layers. The method comprises: preparing a first solution from an organic salt of a first multivalent metal in a first solvent; preparing a second solution comprising a halide of a monovalent cation, a halide of a second bi-, tri- or tetravalent metal, in a second solvent; mixing the first solution with the second solution; and depositing the mixture of the first and second solutions on a substrate. The first multivalent metal is a transition or alkaline earth element, and the second bivalent metal is tin and/or lead, or the trivalent metal is bismuth or antimony, or the tetravalent metal is tin. The invention also relates to a nanocomposite and to the uses of halide perovskite nanocrystal layers, particularly for photovoltaic applications, for optoelectronic applications, as sensors, etc.

Classes IPC  ?

• C01G 21/00 - Composés du plomb
• B82Y 40/00 - Fabrication ou traitement des nanostructures
• H01L 31/0264 - Matériaux inorganiques

Abrégé

Disclosed are: a mononuclear Ru(III) compound comprising two molecules of 2,2'-biimidazole as ligands; a method for obtaining same; and the therapeutic use thereof, preferably as an anti-carcinogenic agent. The cancer may be breast cancer, gastric cancer or colon cancer, preferably triple negative A (TNA) and/or luminal B breast cancer.

Classes IPC  ?

• C07D 233/90 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
• C07F 15/00 - Composés contenant des éléments des groupes 8, 9, 10 ou 18 du tableau périodique
• A61K 31/4178 - 1,3-Diazoles non condensés et contenant d'autres hétérocycles, p. ex. pilocarpine, nitrofurantoïne
• A61K 31/295 - Composés de métaux du groupe du fer
• A61P 35/00 - Agents anticancéreux

Abrégé

The present invention relates to novel differentially methylated genetic elements associated with cutaneous Spitzoid tumors. The invention also relates to improved methods for classifying said tumors.

Classes IPC  ?

• C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer

Abrégé

The present invention relates to a photocatalyst nanomaterial comprising a solid substrate and a metal oxide/oxyhydroxide arranged on the solid substrate forming a coating having a thickness comprised between 1 nm and 1 micrometer and having an amorphous structure. The invention also relates to a nanometric coating which comprises the described photocatalyst material and metallic nanoparticles, as well as to the method for obtaining the catalyst material, to the use of the catalyst material as a photocatalyst in the ultrafast synthesis of metallic nanoparticles, and to the use of the nanometric coating in the manufacture of optical sensors, biocidal coatings and elimination of reactive oxygen species.

Classes IPC  ?

• B01J 21/06 - Silicium, titane, zirconium ou hafniumLeurs oxydes ou hydroxydes
• C23C 18/16 - Revêtement chimique par décomposition soit de composés liquides, soit de solutions des composés constituant le revêtement, ne laissant pas de produits de réaction du matériau de la surface dans le revêtementDépôt par contact par réduction ou par substitution, p. ex. dépôt sans courant électrique
• B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
• B82Y 40/00 - Fabrication ou traitement des nanostructures

Abrégé

A device for detecting photons and charged particles includes a first photon-detecting panel, which causes a Compton scattering of incident radiation with charged particles, such that the wavelength thereof increases, losing part of their energy, generating a signal. A central charged particle-detecting panel, following the first photon-detecting panel on a side opposite that of the incident radiation, identifies charged particles generated in the first photon-detecting panel, generating a signal. A second photon-detecting panel, follows the central charged particle-detecting panel on a side opposite that of the first photon-detecting panel. Scattered photons and/or charged particles are generated in the first photon-detecting panel interact, generating a signal.

Classes IPC  ?

• G01T 1/02 - Dosimètres
• A61N 5/10 - RadiothérapieTraitement aux rayons gammaTraitement par irradiation de particules
• G01T 1/202 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant du cristal
• G01T 1/24 - Mesure de l'intensité de radiation avec des détecteurs à semi-conducteurs

Abrégé

The invention relates to a diffractive device for chemical and biological analysis based on structured receptors on waveguides, which comprises: a waveguide and a recognition element consisting of a grating with receptors arranged on the waveguide and are intended to interact with target compounds present in a sample; and a radiation source that emits an incident beam propagated through the waveguide, interacting with the recognition element and being diffracted according to Bragg's law, thereby generating a reflected beam and a transmitted beam, which are collected by optical analyzers that record parameters of the reflected beam and of the transmitted beam, enabling multiple analyses to be conducted in a simple, fast, 15 sensitive and quantitative manner, label-free and in real time.

Classes IPC  ?

• G01N 21/47 - Dispersion, c.-à-d. réflexion diffuse

Abrégé

The present invention relates to a memristive device comprising: a first electrode on which an active layer is arranged, said layer comprising an ionic salt, an electronic polymer semiconductor that is a polyphenylene vinylene derivative, a polymer ion conductor that is a polybranched polymer with amine derivative monomers and anhydride derivative monomers; and a second electrode. The invention also relates to the use of said device in microelectronics.

Classes IPC  ?

• H01L 51/05 - Dispositifs à l'état solide qui utilisent des matériaux organiques comme partie active, ou qui utilisent comme partie active une combinaison de matériaux organiques et d'autres matériaux; Procédés ou appareils spécialement adaptés à la fabrication ou au traitement de tels dispositifs ou de leurs parties constitutives spécialement adaptés au redressement, à l'amplification, à la génération d'oscillations ou à la commutation et ayant au moins une barrière de potentiel ou une barrière de surface; Condensateurs ou résistances à l'état solide, ayant au moins une barrière de potentiel ou une barrière de surface

Abrégé

The invention relates to a biosensor and virusometer that allow continuous, real-time detection of viral particles of pathogens, especially SARS-CoV-2, both in indoor and outdoor air and in liquid samples in which the pathogen(s) have been collected. The biosensor (8) comprises a quartz crystal microbalance coated with a layer having one or more antibodies specific to one or more pathogens to be detected. A first virusometer (1) is described, comprising an aerosol collector (5), which makes it possible to increase the concentration of pathogens before taking them to the biosensor (8). A second virusometer comprises a receptacle (14), divided into a first cavity (15) wherein air exhaled by a user is collected and concentrated, and a second cavity (16) wherein the biosensor (8) is arranged.

Classes IPC  ?

• G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
• G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques
• G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
• B01D 47/02 - Séparation de particules dispersées dans l'air, des gaz ou des vapeurs en utilisant un liquide comme agent de séparation par passage de l'air, du gaz ou de la vapeur sur ou à travers un bain liquide
• C12Q 1/24 - Méthodes d'échantillonnage, d'inoculation ou de développement d'un échantillonMéthodes pour isoler physiquement un micro-organisme intact
• G01G 3/13 - Appareils de pesée caractérisés par l'utilisation d'organes déformables par élasticité, p. ex. balances à ressort dans lesquels l'élément de pesée est constitué par un corps solide soumis à une pression ou une traction pendant la pesée le corps solide présentant des propriétés piézo-électriques ou piézo-résistives

Abrégé

The present invention relates to an enhanced catalytic nickel oxide sheet having an organic part which includes non-stoichiometric nickel oxides dispersed in an organic matrix, wherein the catalytic sheet is supported on a substrate. The invention also relates to a method for obtaining the catalytic film and to its uses as an electrode in electrocatalysis of water or in photocatalysis.

Classes IPC  ?

• B01J 23/755 - Nickel
• B01J 31/02 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques
• B01J 35/06 - Etoffes ou filaments
• B01J 35/00 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général
• B01J 37/02 - Imprégnation, revêtement ou précipitation
• B01J 37/08 - Traitement thermique

Abrégé

The present invention relates to a method for measuring the levels of Protein C (PROC), preferably Activated Protein C (APC), in a subject in need thereof, the method comprising a step of performing an enzymatic digestion of one or more biological samples isolated from the subject, and a step of measuring the levels of the peptide of SEQ ID NO 1 (LGEYDLR) and/or SEQ ID NO 2 (TFVLNFIK), wherein the levels of SEQ ID NO 1 and/or SEQ ID NO 2 correspond to the levels of PROC, preferably APC, present in said one or more biological samples. Methods for classifying subjects and prognosticating the response to treatments are also included.

Classes IPC  ?

• G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)

Abrégé

The invention relates to inhibitors of MSI2 functions that are able to decrease MSI2 activity, MSI2 transcript levels or MSI2 protein levels in myotonic dystrophy cells or cells with MD phenotype, wherein said inhibitor is for use in the treatment of myotonic dystrophy in a mammal.

Classes IPC  ?

• A61K 31/00 - Préparations médicinales contenant des ingrédients actifs organiques
• A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
• A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
• A61K 31/7125 - Acides nucléiques ou oligonucléotides ayant des liaisons internucléosides modifiées, c.-à-d. autres que des liaisons 3'-5' phosphodiester
• A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
• C07H 21/02 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le ribosyle comme radical saccharide
• C07H 21/04 - Composés contenant au moins deux unités mononucléotide comportant chacune des groupes phosphate ou polyphosphate distincts liés aux radicaux saccharide des groupes nucléoside, p. ex. acides nucléiques avec le désoxyribosyle comme radical saccharide
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles

Abrégé

An apparatus (1) for treating a cancerous target site is provided. The apparatus comprises an electromagnetic emitter (10) comprising one or more electrodes with an electrically insulating coating for preventing electrical contact between the electrodes and the target site. The electromagnetic emitter (10) is configured to provide a tumour treating field at a target site (30) via the one or more electrodes, the tumour treating field being non-ionizing alternating electromagnetic field having a frequency of between 10 kHz to 300 kHz; and further having a magnetic flux density of between 0.1pT and 1mT. The apparatus further comprises a heat source (20) configured to provide heating at the target site to cause hyperthermia at the target site. The apparatus is configured to apply the non-ionizing alternating electromagnetic field and the heating independently. The apparatus comprises an electronic controller for electronically controlling the electromagnetic emitter and the heat source.

Classes IPC  ?

• A61N 2/00 - Magnétothérapie
• A61N 7/02 - Hyperthermie localisée par ultrasons
• A61N 1/40 - Application de champs électriques par couplage inductif ou capacitif

Abrégé

The present invention relates to a layered double hydroxide comprising at least one divalent cation AII or alternatively LiI, at least one trivalent cation BIIIselected from the group consisting of VIII, CoIII, CrIII, MnIII, FeIII, GaIII and lanthanides. The present invention also relates to a process for the synthesis of said layered double hydroxide and uses thereof.

Classes IPC  ?

• C01G 53/00 - Composés du nickel

Abrégé

The present invention relates to compositions comprising Pterostilbene, or a pharmaceutically acceptable salt thereof, in combination with Silibinin, or a pharmaceutically acceptable salt thereof, and their use in the treatment, prevention, amelioration or reduction of diseases induced by ionizing radiation in a subject. The compositions and the uses can further comprise at least one or more radiomitigator compound/s, preferably NAD+ boosters and/or FSL-1.

Classes IPC  ?

• A61K 31/05 - Phénols
• A61K 31/365 - Lactones
• A61P 39/00 - Agents protecteurs généraux ou antipoisons
• A61P 39/06 - Antiradicaux libres ou antioxydants

Abrégé

Disclosed are a Lactobacillus plantarum strain, the probiotic use of same by means of a gastro-resistant capsule, and a bioactive product coated with an antimicrobial whey coating formulation obtained by fermenting whey using said strain. Also disclosed are a method for obtaining the foregoing, and the food use of the bioactive product, preferably to inhibit fungal growth in cheese.

Classes IPC  ?

• C12N 1/20 - BactériesLeurs milieux de culture
• A23L 3/3571 - Micro-organismes; Enzymes
• A23C 9/123 - Préparations à base de lait fermentéTraitements utilisant des micro-organismes ou des enzymes ne comportant que des micro-organismes de la famille des lactobactériacéesYoghourt
• A23C 19/16 - Recouvrement de la surface du fromage, p. ex. avec de la paraffine
• B65D 81/28 - Emploi de moyens de préservation des aliments, de fongicides, d'insecticides ou de produits repoussant les animaux
• C12R 1/25 - Lactobacillus plantarum

Abrégé

A method for obtaining bimodal mesoporous materials based on silicon oxides by using microwave radiation. A method for obtaining bimodal mesoporous materials, based on silicon oxides, from athranic precursors, characterized in that it comprises: - a first step of forming a mesostructured material containing organic matter, - and a second step of eliminating the organic matter contained in the mesostructured material, by calcination, obtaining a bimodal mesoposporous material based on silicon oxide, such that at least one of the two steps is carried out by irradiation of the corresponding starting material, with microwave radiation from solid state sources.

Classes IPC  ?

• C01B 37/02 - Polymorphes de silice cristallins, p. ex. silicalites

Abrégé

Modulation of microRNAs against myotonic dystrophy type 1 and antagonists of microRNAs therefor. The invention provides the use of inhibitors of microRNAs repressors of MBNL1 and/or MBNL2 genes for the manufacture of a medicinal product for the treatment of myotonic dystrophy 1. Inhibiting these microRNAs allows to increase the endogenous levels of the corresponding proteins MBNL1 and/or MBNL2, thereby alleviating symptoms of the disease, especially when inhibiting repressors that are expressed in the main affected organs: skeletal muscle, heart or organs of the central nervous system. The inhibition of the microRNAs miR-23b-3p and miR-218-5p is preferred. It also provides oligoribonucleotide or oligoribonucleotide analogue antagonists suitable therefor, preferably antagomiRs directed against the microRNAs mentioned with chemical modifications that enhance their interaction with the target, their stability in vivo and their ability to penetrate into the cells and distribute throughout tissues and organs.

Classes IPC  ?

• A61K 31/7115 - Acides nucléiques ou oligonucléotides ayant des bases modifiées, c.-à-d. autres que l'adénine, la guanine, la cytosine, l'uracile ou la thymine
• C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
• A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
• A61P 21/00 - Médicaments pour le traitement des troubles du système musculaire ou neuromusculaire

Abrégé

R,R R from the field diaphragm (5).

Classes IPC  ?

• H04N 5/225 - Caméras de télévision
• G02B 30/00 - Systèmes ou appareils optiques pour produire des effets tridimensionnels [3D], p. ex. des effets stéréoscopiques

Abrégé

a computational entity to perform a computational reconstruction of the object wavefront from the spatial and angular information. Other aspects of the invention relate to a method, a computer program and a product incorporating the same, adapted for the performance of the functions of the computational entity of the microscope, as well as to a module and a kit for a microscope.

Classes IPC  ?

• G02B 21/06 - Moyens pour éclairer un échantillon
• G01J 9/00 - Mesure du déphasage des rayons lumineuxRecherche du degré de cohérenceMesure de la longueur d'onde des rayons lumineux
• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection

Abrégé

A method or microbioassay for evaluating the toxicity of an aqueous sample are described. A kit that allows the toxicity of an aqueous sample to be evaluated according to said method, comprising the use of phycobionts isolated from lichen, is also described. The use of said kit to evaluate the toxicity of an aqueous sample is also described.

Classes IPC  ?

• G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
• G01N 33/18 - Eau
• C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables

Abrégé

The present invention relates to a compound 1 or 2 or a composition comprising same. The invention also relates to a method for obtaining compound 1 or 2, and to the use of the compounds to detect GHB in beverages. The invention also includes a device or kit for used to detect GHB in beverages.

Classes IPC  ?

• C07C 335/16 - Dérivés de thiourée ayant des atomes d'azote de groupes thiourée liés à des atomes de carbone de cycles aromatiques à six chaînons d'un squelette carboné
• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
• G01N 31/22 - Utilisation des réactifs chimiques
• G01N 33/14 - Boissons
• C07C 59/01 - Composés saturés ne comportant qu'un groupe carboxyle et contenant des groupes hydroxyle ou O-métal

Abrégé

The present invention relates to a compound 1 or 2 or a composition comprising same. The present invention also relates to a method for producing a compound 1 or 2, and the use thereof to detect GHB in drinks and urine. The invention also includes a device or kit for use in the detection of GHB in drinks and urine.

Classes IPC  ?

• C07D 263/60 - NaphtoxazolesNaphtoxazoles hydrogénés
• C07D 493/10 - Systèmes condensés en spiro
• G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
• G01N 31/22 - Utilisation des réactifs chimiques
• G01N 33/14 - Boissons
• G01N 33/493 - Analyse physique de matériau biologique de matériau biologique liquide d'urine
• C07C 59/01 - Composés saturés ne comportant qu'un groupe carboxyle et contenant des groupes hydroxyle ou O-métal

Produits et services

Scientific, research, navigation, surveying, photographic, cinematographic, audiovisual, optical, weighing, measuring, signalling, detecting, testing, inspecting, life-saving and teaching apparatus and instruments; apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling the distribution or use of electricity; apparatus and instruments for recording, transmitting, reproducing or processing sound, images or data; recorded and downloadable media, computer software, blank digital or analogue recording and storage media; mechanisms for coin-operated apparatus; cash registers, calculating devices; computers and computer peripheral devices; diving suits, divers' masks, ear plugs for divers, nose clips for divers and swimmers, gloves for divers, breathing apparatus for underwater swimming; fire-extinguishing apparatus; bioinformatics software; Software for remote diagnostics; Software for diagnostics and troubleshooting; Maintenance software; Predictive maintenance software; Machine learning software; Machine learning software for surveillance; Machine learning software for analysis; Machine learning software for healthcare; Artificial intelligence and machine learning software; Software for the integration of artificial intelligence and machine learning in the field of Big Data. Scientific and technological services and research and design relating thereto; industrial analysis, industrial research and industrial design services; quality control and authentication services; design and development of computer hardware and software; Development and testing of computing methods, algorithms and software; Research and development in the field of diagnostic preparations; Computer aided diagnostic testing services; Design and development of medical diagnostic apparatus; Computer software maintenance; Repair of software [maintenance, updating]; Creation, maintenance and adaptation of software; installation and maintenance of database software; Maintenance of software for communication systems; Rental and maintenance of computer software; Design, maintenance and up-dating of computer software; Installation, maintenance, repair and servicing of computer software; Development, updating and maintenance of software and database systems; Consultancy and information services relating to the design, programming and maintenance of computer software; Research and development of computer software; Research relating to the development of computer programs and software; Software as a service [SaaS] services featuring software for machine learning, deep learning and deep neural networks. Medical services; veterinary services; hygienic and beauty care for human beings or animals; agriculture, aquaculture, horticulture and forestry services; medical diagnostic services; medical testing for diagnostic or treatment purposes; Medical analysis services for the diagnosis and prediction of sepsis and septic shock.

Abrégé

LeishmaniaLeishmania species, comparable or superior to that of the active ingredient of the drug commonly used to treat this disease, but with a macrophage toxicity similar to or, in most cases, lower than that of the commercial reference compound, and with higher selectivity indices against strains representative of the three clinical forms of the disease: cutaneous, mucocutaneous and visceral. The compounds show ability to inhibit parasite superoxide dismutase, generally at concentrations lower than those required to inhibit human superoxide dismutase. All this supports its usefulness for treating leishmaniasis and also trypanosomiasis.

Classes IPC  ?

• A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
• A61P 33/02 - Antiprotozoaires, p. ex. pour le traitement de la leishmaniose, de la trichomonase, de la toxoplasmose
• C07D 221/00 - Composés hétérocycliques contenant des cycles à six chaînons ne comportant qu'un atome d'azote comme unique hétéro-atome du cycle, non prévus par les groupes
• C07D 215/02 - Composés hétérocycliques contenant les systèmes cycliques de la quinoléine ou de la quinoléine hydrogénée ne comportant pas de liaison entre l'atome d'azote du cycle et un chaînon non cyclique ou ne comportant que des atomes d'hydrogène ou de carbone liés directement à l'atome d'azote du cycle

Abrégé

The invention relates to a compound or to a pharmaceutical composition thereof for their use in the treatment and/or prevention of viral infections caused by coronaviruses, particularly to COVID-19 disease caused by SARS-CoV-2 coronavirus. The invention also relates to an antiviral which comprises said compounds or pharmaceutical compositions thereof.

Classes IPC  ?

• A61K 31/546 - Composés contenant des systèmes cycliques thia-5 aza-1 bicyclo [4.2.0] octane, c.-à-d. composés contenant un système cyclique de formule , p. ex. céphalosporines, céfaclor, céphalexine contenant d'autres hétérocycles, p. ex. céphalotine
• A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
• A61P 31/14 - Antiviraux pour le traitement des virus ARN
• A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire

Abrégé

The present invention is a gut microbiota composition comprising at least one species of genus Clostridium or Tissierella (family Clostridiaceae), Lactobacillus (family Lactobacillaceae), Ruminococcus (family Ruminococcaceae); Megamonas and Anaerovibrio (family Selenomonadaceae), Acetitomaculum and Roseburia (family Lachnospiraceae), Megasphaera (family Veillonellaceae), Leuconostoc (family Leuconostocaceae), Sutterella or the species Dakarella massiliensis (family Sutterellaceae), Schwartzia succinivorans (family Selenomonadaceae) or Firmicutes bacterium CAG:95. for the specific prevention and/or treatment of a mental disorder with memory impairment in a subject, and the form of administration of said microbiota composition.

Classes IPC  ?

• A61K 35/74 - Bactéries
• A61K 35/745 - Bifidobactéries
• A61K 35/747 - Lactobacilles, p. ex. L. acidophilus ou L. brevis
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence

Abrégé

The present invention relates to a device comprising a mixed matrix membrane, wherein said mixed matrix membrane is a polymeric membrane in which at least one metal-organic framework (MOF) having formula (I) is dispersed: XIICuII63222O, wherein X, Z, Y and n are as defined in the text. Said device can be advantageously used for the removal of contaminants from the waters. Processes and uses of said device for the decontamination of the waters from contaminating metals, such as mercury and cadmium, therefore fall within the invention.

Classes IPC  ?

• B01D 69/14 - Membranes dynamiques
• B01D 71/34 - Fluorure de polyvinylidène
• B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide-acides ou précurseurs similaires de polyimides
• B01D 71/68 - PolysulfonesPolyéthersulfones
• B01J 20/22 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance organique
• B01J 31/16 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination
• C07F 1/08 - Composés du cuivre
• B01D 71/02 - Matériaux inorganiques

Abrégé

The present invention relates to rosin microspheres, the method for preparing same, and the use thereof as a system for incorporating active elements into materials and solutions. Consequently, the present invention relates to compositions of natural resins and microspheres or microcapsules of the matrix type containing an excipient for incorporation into other media.

Classes IPC  ?

• C08L 93/04 - Collophane
• B05D 1/04 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces réalisés par pulvérisation comportant l'emploi d'un champ électrostatique
• A01N 25/04 - Dispersions ou gels

Abrégé

The invention comprises a mechanical collimator (1) which receives particles from a gamma radiation source (61) and/or a neutron source (62), a neutron-absorbent material that is virtually transparent to gamma radiation; a first detector (2) that comprises a scintillation crystal with neutron-gamma discrimination capability and a position-sensitive photosensor, coupled to the mechanical collimator (1); one or more detector blocks with gamma or neutron-gamma radiation scintillation crystals (3) and position-sensitive photosensors, after the first detector (2), on a face opposite the mechanical collimator (1); and an acquisition and processing module (4) connected to the detectors (2, 3), the device being suitable for use in inspections relating to nuclear safety, port safety, nuclear threats and accidents, and hadron therapy treatments and nuclear medicine.

Classes IPC  ?

• G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
• G01T 3/06 - Mesure de flux de neutrons avec des détecteurs à scintillation

Abrégé

Candida aurisC. aurisC. aurisC. aurisC. auris.

Classes IPC  ?

• C12Q 1/6895 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour la détection ou l’identification d’organismes pour les plantes, les champignons ou les algues
• G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
• B82Y 5/00 - Nanobiotechnologie ou nanomédecine, p. ex. génie protéique ou administration de médicaments
• B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires

Abrégé

The invention relates to a plenoptic ocular device intended to be coupled in an ocular port of an optical instrument configured to generate a real image of a sample on a focal plane situated in a region close to said ocular port, said plenoptic ocular device being configured to capture said real image, generate a set of elemental images and send them to recording means with spatial discretisation which in turn comprises communication means configured to transmit the set of elemental images to external image processing means.

Classes IPC  ?

• G02B 21/36 - Microscopes aménagés pour la photographie ou la projection
• G02B 27/00 - Systèmes ou appareils optiques non prévus dans aucun des groupes ,

Abrégé

The present invention relates to a new family of titanium heterometallic structured metal-organic materials (MOFs) having, among other characteristics, high porosity, stability in an aqueous medium and photocatalytic activity under visible light and UV radiation. The new family of materials has a structural unit that combines tetravalent titanium with multiple combinations of divalent metals with a homogeneous distribution at atomic level in the MOF structure. 2, heterogeneous catalysis, as a component or part of an electronic component and/or as a porous or photoactive coating for controlling pollutants, inter alia.

Classes IPC  ?

• C07F 7/28 - Composés du titane
• C07F 1/08 - Composés du cuivre

Abrégé

The present invention relates to bioconjugates and labeled derivatives of the adducts formed by the reaction of patulin with benzene-1,2-dithiols or their salts. Said conjugates are suitable for the production of antibodies capable of recognizing the aforementioned patulin-(benzene-1,2-dithiol) adducts with high affinity and specificity. Likewise, the present invention also relates to the use of bioconjugates of patulin-(benzene-1,2- dithiol) adducts and of labeled derivatives thereof as assay antigens. Furthermore, the present invention also relates to immunochemical methods for the analysis of patulin, using the bioconjugates and labeled derivatives and antibodies of the invention, which include a previous step to convert patulin quantitatively into these adducts. This invention also provides a kit for analyzing patulin comprising a benzene-1,2-dithiol or its salts, antibodies against patulin-(benzene-1,2-dithiol) adducts, and assay antigens.

Classes IPC  ?

• G01N 33/531 - Production de matériaux de tests immunochimiques
• A61K 39/385 - Haptènes ou antigènes, liés à des supports
• C07K 16/44 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel non prévu ailleurs

Abrégé

The titanium(IV) and iron(III) MOF solid MUV-17 (TiFe2), has the general formula (1): [TiIVFeIII2(O)(L)2(X)3]S, where X is each equal or different selected from: O2-, OH-, H2O, F-, Cl-, Br-, I-, NO3-, ClO4-, BF4-, SCN-, OH-,CH3COO-, C5H7O2-, SO42-and CO32-N,N'N, N'N,N'Nnn-propanol, water and mixtures thereof. The titanium(IV) and iron(III) MOF solid has long-term catalytic activity for the degradation of toxic compounds. The method for obtaining them comprises 10 dissolving the components under anaerobic conditions. The invention also relates to the use of the titanium(IV) and iron(III) MOF solid as an additive with toxic compound detoxifying properties.

Classes IPC  ?

• C07F 7/28 - Composés du titane
• C07F 15/02 - Composés du fer
• C07C 63/307 - Acides tricarboxyliques monocycliques
• B01J 21/06 - Silicium, titane, zirconium ou hafniumLeurs oxydes ou hydroxydes

Abrégé

Described is a solution for determining events related to photons and charged particles useful in therapies that employ methodologies related to hadron therapy. In one aspect, the invention relates to a device having a sandwich-type structure of photon-detecting panels (1) and charged-particle-detecting panels (2), which can be suitably associated with respective sensors. Also included is a method for detecting photons and charged particles, which uses the device. Lastly, a specific use of the subject matter of the invention in hadron therapy is described.

Classes IPC  ?

• G01T 1/20 - Mesure de l'intensité de radiation avec des détecteurs à scintillation
• G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations

Abrégé

The invention relates to a diffractive device (18) for chemical and biological analysis based on structured receptors on waveguides, which comprises: a waveguide (1) and a recognition element (3) consisting of a network of receptors (11) that are disposed on the waveguide (1) and are intended to interact with target compounds (12) present in a sample; and a radiation source (4) that emits an incident beam (5) propagated through the waveguide (1), interacting with the recognition element (3) and being diffracted according to Bragg's law, thereby generating a reflected beam (6) and a transmitted beam (7), which are collected by optical analysers (8, 17) that register parameters of the reflected beam (6) and of the transmitted beam (7), enabling multiple analyses to be conducted in a simple, fast, sensitive and quantitative manner, label-free and in real time.

Classes IPC  ?

• G01N 21/17 - Systèmes dans lesquels la lumière incidente est modifiée suivant les propriétés du matériau examiné

Abrégé

T. castaneum.

Classes IPC  ?

• C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
• A61K 38/00 - Préparations médicinales contenant des peptides
• A61P 31/04 - Agents antibactériens
• A61P 35/00 - Agents anticancéreux
• A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur

Abrégé

The present invention relates to an enhanced catalytic nickel oxide sheet having an organic part which includes non-stoichiometric nickel oxides dispersed in an organic matrix, wherein the catalytic sheet is supported on a substrate. The invention also relates to a method for obtaining the catalytic film and to its uses as an electrode in electrocatalysis of water or in photocatalysis.

Classes IPC  ?

• B01J 23/755 - Nickel
• B01J 31/02 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des composés organiques ou des hydrures métalliques
• C01B 13/32 - Méthodes de préparation des oxydes ou hydroxydes en général par oxydation ou hydrolyse d'éléments ou de composés à l'état liquide ou solide

Abrégé

The invention relates to a method for identifying a compound with potential pesticide activity against an organism containing chitin, the compound being an inhibitor of chitin deacetylase (CDA). The method comprises cheminformatics and experimental approximations that include molecular topology equations to examine the experimental chemical and analysis databases of the identified compounds to test their activities as pesticides. More specifically, the invention relates to the experimental analysis of a set of 20 compounds and their use as fungicides, arthopocides and/or nematicides. In addition, the specificity of these compounds as CDA inhibitors was confirmed using enzyme inhibition testing and docking. The method of the invention is useful for identifying CDA inhibitors useful as agricultural fungicides or for controlling other pests such as insects or nematodes that are harmful for crops and/or mammals.

Classes IPC  ?

• G16B 15/30 - Ciblage de médicament à l’aide de données structurellesPrévision d’amarrage ou de liaison moléculaire

Abrégé

Described is moxifloxacin, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising it, for use in the prevention and/or treatment of spinal muscular atrophy (SMA).

Classes IPC  ?

• A61K 31/47 - QuinoléinesIsoquinoléines
• A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
• A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique

Abrégé

The present invention relates to a method for adsorbing nitrates from water by means of active modified silica from rice straw ash, which comprises the following steps: (a) adding silica from rice straw ash to a mixture of alcohol and water, obtaining a suspension; (b) adding a catalyst to the suspension of step (a) and keeping stirred at room temperature; (c) adding an amino alkoxysilane compound to the mixture of step (b) and keeping stirred at room temperature, obtaining modified silica; (d) treating the modified silica obtained in step (c) with an acid, by means of continuous recirculation, obtaining active modified silica; and (e) putting the active modified silica obtained in step (d) in contact with the water from which nitrates are to be removed.

Classes IPC  ?

• C02F 1/28 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par absorption ou adsorption
• B01J 20/10 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation contenant une substance inorganique contenant de la silice ou un silicate