The present invention relates to a system (1000) and method for transporting bees, which allows live bees to be exported, in hibernation state, by sea. The system (1000) comprises: a packaging device (10) comprising a drawer (11) with a funnel (12) through which the bees fall and are collected; at least one transport box (20) comprising a body (21), a cover (22) that is the same shape as, and larger than, the body (21) to completely cover the sidewalls and top of the body (21), two ventilation openings (23) arranged in two of the sidewalls of the body (21), at least one floor (24) arranged to cover the bottom of the body (21), the bees being collected in the body (21), and a feeder disposed in an opening (25) of the body (21), which feeder has a total volume of 6-8 L and contains 5-6 L of gel feed and an internal space for accommodating the bees and allowing same to feed from the perimeter of the feeder, where the gel feed is located; and at least one refrigerated container (30) in which the transport boxes (20) are arranged, pre-palletised, for the maritime transport thereof.
A01K 53/00 - Mangeoires ou abreuvoirs pour abeilles
B65D 85/50 - Réceptacles, éléments d'emballage ou paquets spécialement adaptés à des objets ou à des matériaux particuliers pour organismes vivants, objets ou matériaux sensibles aux changements d'ambiance ou de conditions atmosphériques, p. ex. pour animaux terrestres, oiseaux, poissons, plantes aquatiques, plantes non aquatiques, oignons de fleurs, fleurs coupées ou feuillage
2.
USE OF MESENCHYMAL STEM CELLS OVEREXPRESSING PACER FOR THE TREATMENT OF DISEASES WITH INFLAMMATORY ORIGIN AND/OR COMPONENT
The present invention provides Mesenchymal Stem Cells (MSC) genetically modified for overexpressing Pacer—a newly described autophagy protein—where these MSC have immunomodulatory effects. The invention also provides the method for obtaining the MSC overexpressing Pacer and pharmaceutical formulations comprising said cells.
The present invention provides Mesenchymal Stem Cells (MSC) genetically modified for overexpressing Pacer—a newly described autophagy protein—where these MSC have immunomodulatory effects. The invention also provides the method for obtaining the MSC overexpressing Pacer and pharmaceutical formulations comprising said cells.
The MSC according to the invention are useful in the treatment of diseases with inflammatory origin and/or component.
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
The present invention relates to a composition for the treatment and prevention of American foulbrood (AFB) to protect honey bee apiaries, a method for obtaining said composition and the use thereof for the prevention and treatment of microbial diseases, especially those caused by Paenibacillus larvae. The composition of the invention comprises proteins obtained from a microbial consortium deposited in the American Type Culture Collection (ATCC) under number PTA-127132, which comprises Brevibacillus laterosporus, Bacillus licheniformis, Enterococcus faecalis and Clostridium perfringens.
The present invention relates to a method for synthesising the compound desmethylxestospongin B (dmXeB), wherein an esterification of azidoalcohol 4 with 2-(benzyloxy)-5-chloropentanoic acid 5 or 5-chloropentanoic acid is performed to obtain intermediates 2 and 3 via Ireland-Claisen rearrangement to establish stereogenic centres at C9' and C9, respectively; next, ω-amino acid precursors 2 and 3 are combined by sequential amide formation to obtain bis-lactam-1; and subsequently, by means of final hydrogenation of the double bonds of bis-lactam-1 in ethyl acetate, the compound dmXeB is obtained.
C07D 498/22 - Composés hétérocycliques contenant dans le système condensé au moins un hétérocycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle dans lesquels le système condensé contient au moins quatre hétérocycles
A61K 31/537 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un oxygène comme hétéro-atomes d'un cycle, p. ex. 1,2-oxazines condensées en spiro ou formant une partie de systèmes cycliques pontés
A. chilensis callus culture, the second step consists of eliciting the production of anthocyanins in the culture, to obtain the desired product. In this way, callus cultivation is presented as a new alternative to provide a nutritional additive rich in anthocyanins appropriate for the food industry, or any other application that requires anthocyanins that does not depend on seasonality or environmental factors.
C12P 17/06 - Préparation de composés hétérocycliques comportant O, N, S, Se ou Te comme uniques hétéro-atomes du cycle l'oxygène comme unique hétéro-atome du cycle contenant un hétérocycle à six chaînons, p. ex. fluorescéine
A23L 5/43 - Adjonction de colorants ou de pigments, p. ex. en combinaison avec des azurants optiques en utilisant des colorants ou des pigments organiques d'origine naturelle, leurs doublons artificiels ou leurs dérivés
A23L 33/105 - Extraits de plantes, leurs doublons artificiels ou leurs dérivés
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
The present invention provides mesenchymal stem cells (MSCs) genetically modified to overexpress Pacer, a recently described autophagy protein, wherein the MSCs have immunomodulating effects. The invention also provides a method for obtaining the Pacer-overexpressing MSCs and pharmaceutical formulations comprising the cells. The MSCs according to the invention are useful in treating diseases with an inflammatory origin and/or component.
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
7.
NANOFORMULATION FOR TREATING AND/OR PREVENTING WOUNDS OR ULCERS THAT ARE INFECTED OR HAVE CRITICAL COLONISATION, WHICH INCLUDES COPPER NANOPARTICLES AND COLLAGEN-DERIVED PEPTIDES
The present invention describes a nanoformulation for treating and/or preventing wounds or ulcers that are infected or have critical colonisation, which includes copper nanoparticles and collagen-derived peptides, and to the applications of the nanoformulation as an antimicrobial and/or as a product that stimulates healing. Also described are products for treating and/or preventing infected wounds or ulcers that include the nanoformulation, in the form of a dressing or topical-use formulations, such as creams, waxes, gels and sprays.
C07K 14/78 - Peptides du tissu connectif, p. ex. collagène, élastine, laminine, fibronectine, vitronectine ou globuline insoluble à froid [CIG]
A61K 8/65 - CollagèneGélatineKératineLeurs dérivés ou produits de dégradation
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
A61Q 19/00 - Préparations pour les soins de la peau
8.
METHOD FOR PRODUCING ANTHOCYANINS FROM ARISTOTELIA CHILENSIS CALLUS CULTURES
Aristotelia chilensisAristotelia chilensis callus cultures, which is divided into two essential steps: the first is obtaining biomass in an A. chilensis callus culture; the second consists in eliciting the production of anthocyanins in the culture, to obtain the desired product. Thus, the callus culture is presented as a new alternative to provide an anthocyanin-rich nutritional additive suitable for the food industry or for any other application requiring anthocyanins that does on depend on seasonality or environmental factors.
The invention relates to a device for determining the height of the knee of a prostrate patient. Said device comprises a foot support, a calf support and a thigh support, wherein said foot support, said calf support and said thigh support are disposed in a line from the base of the foot up to the thighs, and are joined to one another by a pair of adjustment rails, disposed one on each side of the device, wherein each rail is supported by a respective securing element located in the foot support, and each rail is fixed to the respective side of the calf support, and wherein each of the rails slides a respective sliding arm, wherein each sliding arm is joined to a respective side of the thigh support via a pivotable joint, and wherein the device also comprises a magnetic device for determining the height of the knee and a display means so that a user interacts with the measuring of the device.
The present invention relates to a mandibular device for edentate patients to solve the limitations of overdentures and allow a completely edentulous patient to become a partially edentulous patient. The device comprises at least two crowns, each disposed on at least two monophasic implants preferably placed in the canine area of the patient's mandible, such that a removable partial prosthesis is retained by said crowns by incorporating extra-coronal retainers. The invention also relates to the associated method.
A61C 13/00 - Prothèses dentairesLeurs procédés de fabrication
A61C 13/08 - Dents artificiellesFabrication de dents artificielles
A61C 13/10 - Fixation des dents artificielles à un matériau de base artificiel, p. ex. à un palais artificiel ou à des dents artificielles adjacentes
A61C 13/103 - Fixation des dents artificielles à un matériau de base artificiel, p. ex. à un palais artificiel ou à des dents artificielles adjacentes les dents artificielles étant fixées au matériau de base par un élément de fixation distinct, p. ex. un ergot ou une tige
A61C 13/105 - Fixation des dents artificielles à un matériau de base artificiel, p. ex. à un palais artificiel ou à des dents artificielles adjacentes les dents artificielles étant fixées au matériau de base par un élément de fixation distinct, p. ex. un ergot ou une tige l'élément de fixation étant incrusté dans le matériau de base
A61C 13/113 - Prothèses modulaires, p. ex. avec une base préfabriquée ou comportant des rangées de dents préfabriquées
A61C 13/225 - Fixation des prothèses dans la bouche
A61C 13/23 - Fixation des prothèses dans la bouche utilisant des feuilles adhésives ou des compositions adhésives
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
educational services, namely, conducting classes, seminars, conferences and workshops in all fields of education; arranging and conducting educational conferences; educational services in the nature of correspondence schools; teaching in the fields of technology and economics; libraries; organizing and conducting intercollegiate sports exhibitions; organizing and conducting educational cultural exhibitions; computer services, namely, providing on-line articles, books and magazines in the field of technology and economics
