The present invention relates to a mobile apparatus (1) for the automatic on-demand preparation and injection or infusion of a dose of radiopharmaceutical product to a plurality of patients, in which a kit (32, 100) comprises a controlled syringe (101) for withdrawing the radiopharmaceutical product after piercing, by means of a motorized system, a septum of the radiopharmaceutical product vial (31, 107), and a three-way valve (103) which successively allows the radiopharmaceutical product to be withdrawn into the syringe (101), mixed with a quantity of saline (33, 109), and injected into a patient via three respective fluid paths (106, 108, 241 and optionally 242).
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/145 - Perfusion sous pression, p. ex. utilisant des pompes utilisant des réservoirs sous pression, p. ex. au moyen de pistons
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
2.
DEVICE AND METHOD FOR CARRYING OUT AUTOMATED RADIOCHEMICAL PURITY ANALYSIS OF PET TRACERS
The present invention relates to a device that allows to fully automate radiochemical purity analysis of radiolabelled solution samples on the basis of a chromatogram obtained by Thin Layer Chromatography (TLC), said device comprising a disposable TLC strip holder assembly, a radioactivity detector and an automatic equipment containing a pipettor.
B01D 15/10 - Adsorption sélective, p. ex. chromatographie caractérisée par des caractéristiques de structure ou de fonctionnement
G01N 30/95 - Détecteurs spécialement adaptés à cet effetAnalyse des signaux
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
3.
APPARATUS FOR MEASURING THE ACTIVITY OF A RADIOACTIVE SOLUTION IN A SYRINGE, AND METHOD FOR CONTROLLING THE APPARATUS
The present application relates to an apparatus (1) for measuring the activity of a sample of radioactive solution, in a given volume V, comprising: - a shielded portable container with a specimen holder (10); - a vessel (2) having a longitudinal axis of symmetry and containing the radioactive solution; - at least two radiation detectors (3, 4,...), wherein the detectors (3, 4,...) are arranged laterally with respect to the longitudinal axis of the vessel (2); - a device (11) for converting the radiation received by each detector (3, 4,...) into a corresponding electrical signal M1, M2,...; - means (12) for processing the electrical signal and display means (13); characterised in that the means (12) for processing the signal are configured to update a given correlation between the respective electrical signals M1, M2,... representative of the activity of the sample and the volume V of the sample, thereby making it possible to obtain the activity independently of the volume of the sample.
A device for performing by flipping-over a quantitative liquid transfer from a crimp capped vial to another vial, container, or cassette includes: an extension tube equipped with a spike on one end; a shielded pot with a lid, intended to enclose the crimp capped vial; and a component including: a lower cylindrical part with a beveled cylindrical notch for receiving in tight insertion a crimp capped vial, the notch having an aperture on a side of the lower cylindrical part; an upper cylindrical part in communication with the lower cylindrical part and including a hollow cylindrical protrusion for guiding the extension tube equipped with a spike, a groove being provided in the upper cylindrical part for keeping the extension tube in place during the handling of the device; and a central cylindrical part, provided between the lower and the upper cylindrical parts, that includes a furrow.
A method for synthesizing an aluminium-fluoride complex obtainable by reacting together: a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; or a chelate bearing molecule precomplexed with aluminium(III), obtained from treating the chelate bearing molecule with a salt made of aluminium(III) and counterions of aluminium(III) other than chloride(I), and a fluoride anion; the fluoride being [19F]fluoride or radioactive [18F]fluoride; wherein the counterions of aluminium(III) other than chloride are selected from bromide, iodide, nitrate, phosphate, sulfate, sulphonate, hydroxide, any anionic salt of natural and non-natural amino acids, 2,4-pentanedionate, 8-hydroxyquinoline, acetate, acrylate, ascorbate, aspartate, benzenesulfonate, benzoate, besylate, bitartrate, camphorsulfonate, citrate, decanoate, esylate, fumarate, gentisate, gluconate, glutamate, glutarate, glycinate dihydroxide, glycolate, hexanoate, hydroxynaphthoate, isethionate, lactate, lactobionate, malate, maleate, malonate, mandelate, mesylate, methylsulfate, methylsulfonate, mucate, napsylate, octanoate, oleate, oxalate, pamoate, pantothenate, phthalate, polygalacturonate, propionate, salicylate, stearate, succinate, tartrate, teoclate, toluenesulfonate, trifluoroacetate, trifluoromethanesulfonate, and any combination thereof.
The present invention relates to a pipette tip (30) for manually, semi-automatically or automatically actuated pipetting, intended to be inserted through a septum (26) into a container (20) in order to collect and inject a liquid (20), characterized in that the pipette tip (30) has one or more axial fins (37) on the outer surface of an insertion section (33), the section (33) being referred to as the finned section, allowing air to flow in or out of the container (20) during a fluid transfer process such as pipetting.
A system for reversibly coupling a syringe for injecting a calibrated product to an actuator, including the actuator, the syringe provided with a pusher having a pusher button and a coupling device, the coupling device including an internal body with longitudinal axis and an outer sleeve intended to move with respect to the internal body along the longitudinal axis, the internal body including a sliding pin ending with a play-take-up plate that is held longitudinally inside the internal body in a rest position by a prestressed spring as well as at least one pair of hooks arranged longitudinally inside the internal body, mounted pivoting and retractable two by two with respect to two respective pins perpendicular to the longitudinal axis, an external part of the hooks being located opposite an internal part of the sleeve, the hooks of a same pair each having a zone for hooking.
A61M 5/00 - Dispositifs pour faire pénétrer des agents dans le corps par introduction sous-cutanée, intravasculaire ou intramusculaireAccessoires à cet effet, p. ex. dispositifs de remplissage ou de nettoyage, appuis-bras
A61M 5/168 - Moyens pour commander l'écoulement des agents vers le corps ou pour doser les agents à introduire dans le corps, p. ex. compteurs de goutte-à-goutte
A61M 5/20 - Seringues automatiques, p. ex. avec tige de piston actionnée automatiquement, avec injection automatique de l'aiguille, à remplissage automatique
A61M 5/315 - PistonsTiges de pistonGuidage, blocage, ou limitation des mouvements de la tigeAccessoires disposés sur la tige pour faciliter le dosage
The present invention relates to a radiation protection device (1) for a syringe containing a radioactive solution, comprising: - a cylindrical shielding body (2) made of a radioprotective material, open at each of the ends (3, 5) thereof, an upstream end (5) comprising a cylinder section having a smaller outer diameter than the cylindrical shielding body (2), the cylinder section having grooves (6) and having, at the top thereof, two arcuate projections (7) capable of conforming to the shape of the flanges (22) of the syringe; and a downstream end (3) having a conical shape capable of accommodating the tip of the syringe; - a rotary securing system (10) for securing the position of the syringe in the cylindrical shielding body (2), capable of cooperating with the upstream end (5) in order to place the rotary securing system (10) in a plurality of defined positions, including at least one position for releasing the syringe and at least one position for immobilising the syringe, via its flanges (22), in relation to the cylindrical shielding body (2).
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Scientific apparatus and instruments for synthesizing and
manipulating chemical and radiochemical products not for
medical use. Scientific apparatus and instruments for synthesizing and
manipulating chemical and radiochemical products for medical
use.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Scientific apparatus and instruments for synthesizing and
manipulating chemical and radiochemical products not for
medical use. Scientific apparatus and instruments for synthesizing and
manipulating chemical and radiochemical products for medical
use.
11.
APPARATUS AND METHOD FOR PERFORMING AUTOMATED QUALITY CONTROL OF A PHARMACEUTICAL PRODUCT
The present invention relates to a shielded apparatus for automated and integrated quality control, in short QC, analysis of a radiopharmaceutical compound, wherein said shielded apparatus has in a front part thereof two entry ports (3, 4) configured to receive a sample loader (5) and a consumable loader (6) respectively, wherein said sample loader (5) is a shielded holder configured to host a vial (74), preferably an optical cuvette, with a sample to be analysed, wherein said consumable loader (6) is a tray-shaped organizer containing in use a reagent block (71) provided with reagents, reference standards and other disposables, a migration chamber with a TLC strip (72), a plurality of disposable tips (73), all necessary to the performance of the above-mentioned analyses, and wherein it contains inside the core module (1) a 3D pipettor (8) cooperating with the disposable tips (73) for performing four different types of fluid transfer, respectively from sample to consumables (81), from sample to analytical equipment (83), from reference standards to consumables (82) and from reference standards to analytical equipment (84).
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Scientific apparatus and instruments for synthesizing and manipulating chemical and radiochemical products not for medical use. Scientific apparatus and instruments for synthesizing and manipulating chemical and radiochemical products for medical use.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
Produits et services
Scientific apparatus and instruments for synthesizing and manipulating chemical and radiochemical products not for medical use. Scientific apparatus and instruments for synthesizing and manipulating chemical and radiochemical products for medical use.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Reagents for testing medical equipment sterility; reagents
for testing the sterility of pharmaceutical and
radiopharmaceutical products and injectable solutions;
biological preparations for monitoring sterilization
processes other than for medical or veterinary use. Scientific, weighing, measuring, checking apparatus and
instruments for testing the sterility of pharmaceutical and
radiopharmaceutical products, injectable solutions and
medical and surgical equipment; scientific, weighing,
measuring, checking apparatus and instruments for testing
the sterility of apparatus and instruments for conducting
quality checks in pharmaceutical chemistry, radiopharmacy
and nuclear medicine, of apparatus and instruments for
production, distribution, handling and analysis for medical
or non-medical use of chemical, pharmaceutical,
radiopharmaceutical products and radioactive materials;
scientific, weighing, measuring, checking apparatus and
instruments for testing the sterility of apparatus for
analysis for medical or non-medical use, of scientific
apparatus and instruments for synthesizing chemical
products for medical or non-medical use, of scientific
apparatus and instruments for treating radioactive materials
for medical or non-medical use, laboratory instruments for
medical or non-medical use; computer software; computer
software for analyzing, viewing and transmitting sterility
testing data for medical equipment, pharmaceutical and
radiopharmaceutical products and injectable solutions;
computer software for analyzing, viewing and transmitting
medical data. Analytical laboratory services; quality control and testing;
sterility testing services for pharmaceutical and
radiopharmaceutical products and injectable solutions;
laboratory research services concerning pharmaceutical and
radiopharmaceutical products; testing and analysis of
materials; medicine testing services; testing of chemical
products; chemical analysis and evaluation services;
sampling and analysis to determine the presence of
contamination; research and development concerning chemical
reagents and scientific apparatus and instruments in the
field of testing and quality control.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Apparatus for the administration of medicines; automatic
medical apparatus for dose injection for humans; metering
pumps for administering medicines in measured quantities for
medical use; infusion pumps for administering medicines;
intravenous infusion pumps for medical use; dosage
dispensers for medical use; apparatus for administering
medical fluids for the administration of
radiopharmaceuticals and disposable products for use
therewith; apparatus for administering contrast agents for
medical use; infusion lines; infusion columns; hypodermic
needles for infusion therapy; medical syringes; multishot
needle syringes; syringe needles for medical use; disposable
needles for hypodermic syringes; syringe pumps for medical
use; valves intended for use in medical infusion
instruments; catheters; tubes for catheters; protectors for
catheters; transfusion tubes; intravenous feeding tubes;
tubing for medical use; medical instruments for therapeutic
monitoring of medicinal treatments; sensors for medical use
for monitoring patients' vital signs; structures for
protection against radiation for medical use. Maintenance, adjustment and repair of surgical and medical
apparatus and instruments, including apparatus for
administering medicines and fluids for medical use. Design and development of medical technologies; design and
development of medical diagnostic apparatus and apparatus
for administering medicines and fluids for medical use;
calibration services relating to medical equipment; computer
program writing services for medical applications; design
and development of software for use in the framework of
medical technology; calibration and recalibration of
surgical and medical apparatus and instruments, including
apparatus for administering medicines and fluids for medical
use.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Apparatus for the administration of medicines; automatic
medical apparatus for dose injection for humans; metering
pumps for administering medicines in measured quantities for
medical use; infusion pumps for administering medicines;
intravenous infusion pumps for medical use; dosage
dispensers for medical use; apparatus for administering
medical fluids for the administration of
radiopharmaceuticals and disposable products for use
therewith; apparatus for administering contrast agents for
medical use; infusion lines; infusion columns; hypodermic
needles for infusion therapy; medical syringes; multishot
needle syringes; syringe needles for medical use; disposable
needles for hypodermic syringes; syringe pumps for medical
use; valves intended for use in medical infusion
instruments; catheters; tubes for catheters; protectors for
catheters; transfusion tubes; intravenous feeding tubes;
tubing for medical use; medical instruments for therapeutic
monitoring of medicinal treatments; sensors for medical use
for monitoring patients' vital signs; structures for
protection against radiation for medical use. Maintenance, adjustment and repair of surgical and medical
apparatus and instruments, including apparatus for
administering medicines and fluids for medical use. Design and development of medical technologies; design and
development of medical diagnostic apparatus and apparatus
for administering medicines and fluids for medical use;
calibration services relating to medical equipment; computer
program writing services for medical applications; design
and development of software for use in the framework of
medical technology; calibration and recalibration of
surgical and medical apparatus and instruments, including
apparatus for administering medicines and fluids for medical
use.
09 - Appareils et instruments scientifiques et électriques
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Data exchange device in the field of radiology,
radiopharmacy and nuclear medicine; software for data
exchange in the field of radiology, radiopharmacy and
nuclear medicine. Electronic data exchange services in the field of radiology,
radiopharmacy and nuclear medicine; wireless transfer of
data via wireless application protocol in the field of
radiology, radiopharmacy and nuclear medicine; providing
communication facilities for the exchange of data by
electronic means in the field of radiology, radiopharmacy
and nuclear medicine. Research and development of computer software, hardware and
protocols for the exchange of data in electronic form in the
field of radiology, radiopharmacy and nuclear medicine.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Appareils pour l'administration de médicaments; appareils médicaux automatiques pour injection de doses aux humains; pompes doseuses pour l'administration de médicaments en quantités mesurées à usage médical; pompes à perfusion pour administrer des médicaments; pompes à perfusion intraveineuse à usage médical; distributeurs-doseurs à usage médical; appareil pour l'administration de fluides médicaux pour l'administration de produits radiopharmaceutiques et produits jetables à utiliser avec ces produits; appareils pour l'administration d'agents de contraste à usage médical; tubes de perfusion; colonnes de perfusion; aiguilles hypodermiques destinées à la thérapie par perfusion; seringues médicales; seringues à aiguilles pour injections multiples; aiguilles pour seringues à usage médical; aiguilles jetables pour seringues hypodermiques; pousses-seringues à usage médical; valves destinées à des instruments médicaux de perfusion; cathéters; tubes pour cathéters; protections pour cathéters; tubes de transfusion; tubes d'alimentation intraveineuse; tubulures à usage médical; instruments médicaux pour la surveillance thérapeutique de traitements médicamenteux; capteurs à usage médical pour la surveillance des constantes vitales des patients; structures de protection contre les radiations à usage médical. (1) Services de maintenance, calibrage, recalibrage, ajustement et réparation d'appareils et instruments chirurgicaux et médicaux, y compris appareils pour l'administration de médicaments et de fluides à usage médical.
(2) Conception et développement de technologies médicales; conception et développement d'appareils de diagnostic médical et d'appareils d'administration de médicaments et de fluides à usage médical; services d'étalonnage relatifs au matériel médical; services d'écriture de programmes informatiques pour applications médicales; conception et développement de logiciels destinés à être utilisés dans le cadre de technologies médicales.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Apparatus for the administration of medicines; automatic
medical apparatus for dose injection for humans; metering
pumps for administering medicines in measured quantities for
medical use; infusion pumps for administering medicines;
intravenous infusion pumps for medical use; dosage
dispensers for medical use; apparatus for administering
medical fluids for the administration of
radiopharmaceuticals and disposable products for use
therewith; apparatus for administering contrast agents for
medical use; infusion lines; infusion columns; hypodermic
needles for infusion therapy; medical syringes; multishot
needle syringes; syringe needles for medical use; disposable
needles for hypodermic syringes; syringe pumps for medical
use; valves intended for use in medical infusion
instruments; catheters; tubes for catheters; protectors for
catheters; transfusion tubes; intravenous feeding tubes;
tubing for medical use; medical instruments for therapeutic
monitoring of medicinal treatments; sensors for medical use
for monitoring patients' vital signs; structures for
protection against radiation for medical use. Maintenance, calibration, recalibration, adjustment and
repair of surgical and medical apparatus and instruments,
including apparatus for administering drugs and fluids for
medical use. Design and development of medical technologies; design and
development of medical diagnostic apparatus and drug and
fluid delivery apparatus for medical use; calibration
services relating to medical equipment; computer program
writing services for medical applications; design and
development of software for use in the framework of medical
technology.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
apparatus for the administration of medicines, namely, drug delivery catheters and dosage dispensers for administering medicine to patients; automatic medical apparatus for dose injection for humans; metering pumps for administering medicines in measured quantities for medical use; infusion pumps for administering medicines; intravenous infusion pumps for medical use; dosage dispensers for administering medicine to patients, for medical use; medical apparatus for administering medical fluids for the administration of radiopharmaceuticals and disposable medical syringes for use therewith; apparatus for administering contrast agents for medical use; infusion apparatus for therapeutic purposes, namely, infusion lines; infusion apparatus for therapeutic purposes, namely, infusion columns; hypodermic needles for infusion therapy; medical syringes; multishot needle medical syringes; syringe needles for medical use; disposable medical needles for hypodermic syringes; syringe pushers for medical use; valves being component replacement parts for medical infusion instruments for administering drugs; catheters; tubes for use with catheters; protectors for catheters being parts and fittings for catheters; transfusion tubes being medical tubing for transfusion; intravenous feeding tubes; tubing for medical transfusion use; medical instruments for therapeutic monitoring of medicinal treatments; sensors for medical use for monitoring patients' vital signs; structures for protection against radiation for medical use, namely, patient x-ray radiation shields Maintenance, adjustment being repair and repair of surgical and medical apparatus and instruments, in particular apparatus for administering drugs and fluids for medical use Design and development of medical technologies; design and development of medical diagnostic apparatus and apparatus for administering medicines and fluids for medical use; calibration services relating to medical equipment; computer program writing services for medical applications; design and development of software for use in the framework of medical technology; calibration and recalibration of surgical and medical apparatus and instruments, including apparatus for administering medicines and fluids for medical use.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Appareils pour l'administration de médicaments; appareils médicaux automatiques pour injection de doses aux humains; pompes doseuses pour l'administration de médicaments en quantités mesurées à usage médical; pompes à perfusion pour administrer des médicaments; pompes à perfusion intraveineuse à usage médical; distributeurs-doseurs à usage médical; appareil pour l'administration de fluides médicaux pour l'administration de produits radiopharmaceutiques et produits jetables à utiliser avec ces produits; appareils pour l'administration d'agents de contraste à usage médical; tubes de perfusion; colonnes de perfusion; aiguilles hypodermiques destinées à la thérapie par perfusion; seringues médicales; seringues à aiguilles pour injections multiples; aiguilles pour seringues à usage médical; aiguilles jetables pour seringues hypodermiques; pousses-seringues à usage médical; valves destinées à des instruments médicaux de perfusion; cathéters; tubes pour cathéters; protections pour cathéters; tubes de transfusion; tubes d'alimentation intraveineuse; tubulures à usage médical; instruments médicaux pour la surveillance thérapeutique de traitements médicamenteux; capteurs à usage médical pour la surveillance des constantes vitales des patients; structures de protection contre les radiations à usage médical. (1) Services de maintenance, ajustement et réparation d'appareils et instruments chirurgicaux et médicaux, y compris appareils pour l'administration de médicaments et de fluides à usage médical.
(2) Conception et développement de technologies médicales; conception et développement d'appareils de diagnostic médical et d'appareils d'administration de médicaments et de fluides à usage médical; services d'étalonnage relatifs au matériel médical; services d'écriture de programmes informatiques pour applications médicales; conception et développement de logiciels destinés à être utilisés dans le cadre de technologies médicales; services de calibrage et recalibrage d'appareils et instruments chirurgicaux et médicaux, y compris appareils pour l'administration de médicaments et de fluides à usage médical.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Appareils pour l'administration de médicaments; appareils médicaux automatiques pour l'injection de doses pour êtres humains; pompes doseuses pour l'administration de médicaments en quantités mesurées à usage médical; pompes à perfusion pour l'administration de médicaments; pompes à perfusion intraveineuse à usage médical; distributeurs-doseurs à usage médical; appareils pour l'administration de fluides médicaux pour l'administration de produits radiopharmaceutiques et produits jetables à utiliser avec ceux-ci; appareils pour l'administration d'agents de contraste à usage médical; lignes de perfusion; colonnes de perfusion; aiguilles hypodermiques pour thérapie par perfusion; seringues à usage médical; seringues à aiguilles multi-injections; aiguilles de seringues à usage médical; aaiguilles jetables pour seringues hypodermiques; pompes à seringue à usage médical; soupapes destinées à être utilisées dans des instruments de perfusion à usage médical; cathéters; tubes pour cathéters; protections pour cathéters; tubes de transfusion; sondes d'alimentation par voie intraveineuse; tubulures à usage médical; structures de protection contre les rayonnements à usage médical. (1) Services de maintenance, ajustement et réparation d'appareils et instruments chirurgicaux et médicaux, y compris appareils pour l'administration de médicaments et de fluides à usage médical.
(2) Conception et développement de technologies médicales pour l'administration de médicaments et de fluides à usage médical; conception et développement d'appareils de diagnostic médical et d'appareils pour l'administration de médicaments et de fluides à usage médical; services d'étalonnage en lien avec des équipements médicaux; services de rédaction de programmes informatiques pour applications médicales; conception et développement de logiciels à utiliser dans le cadre de technologies médicales pour l'administration de médicaments et de fluides à usage médical; étalonnage et réétalonnage d'instruments et d'appareils chirurgicaux et médicaux, y compris appareils pour l'administration de médicaments et de fluides à usage médical.
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
apparatus for the administration of medicines, namely, drug delivery catheters and dosage dispensers for administering medicine to patients; automatic medical apparatus for dose injection for humans; metering pumps for administering medicines in measured quantities for medical use; infusion pumps for administering medicines; intravenous infusion pumps for medical use; dosage dispensers for administering medicine to patients, for medical use; medical apparatus for administering medical fluids for the administration of radiopharmaceuticals and disposable medical syringes for use therewith; apparatus for administering contrast agents for medical use; infusion apparatus for therapeutic purposes, namely, infusion lines; infusion apparatus for therapeutic purposes, namely, infusion columns; hypodermic needles for infusion therapy; medical syringes; multishot needle medical syringes; syringe needles for medical use; disposable medical needles for hypodermic syringes; syringe pushers for medical use; valves being component replacement parts for medical infusion instruments for administering drugs; catheters; tubes for use with catheters; protectors for catheters being parts and fittings for catheters; transfusion tubes being medical tubing for transfusion; intravenous feeding tubes; tubing for medical transfusion use; medical instruments for therapeutic monitoring of medicinal treatments; sensors for medical use for monitoring patients' vital signs; structures for protection against radiation for medical use, namely, patient x-ray radiation shields Maintenance, adjustment being repair and repair of surgical and medical apparatus and instruments, in particular apparatus for administering drugs and fluids for medical use Design and development of medical technologies; design and development of medical diagnostic apparatus and apparatus for administering medicines and fluids for medical use; calibration services relating to medical equipment; computer program writing services for medical applications; design and development of software for use in the framework of medical technology; calibration and recalibration of surgical and medical apparatus and instruments, including apparatus for administering medicines and fluids for medical use.
09 - Appareils et instruments scientifiques et électriques
38 - Services de télécommunications
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Electronic data exchange device in the nature of an electronic device for exchanging data from dosage dispensers, infusion devices, and injection devices, for use in the field of radiology, radiopharmacy and nuclear medicine; downloadable and recorded software for data exchange in the field of radiology, radiopharmacy and nuclear medicine Electronic exchange of data stored in databases accessible via telecommunication networks for professionals in the field of radiology, radiopharmacy and nuclear medicine; wireless transfer of data by wireless telecommunication in the field of radiology, radiopharmacy and nuclear medicine; providing communication facilities being the rental of telecommunication facilities for the exchange of data by electronic means in the field of radiology, radiopharmacy and nuclear medicine Research and development of computer software, hardware and protocols for the exchange of data in electronic form in the field of radiology, radiopharmacy and nuclear medicine
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
09 - Appareils et instruments scientifiques et électriques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Reagents for testing medical equipment sterility; reagents for testing the sterility of pharmaceutical and radiopharmaceutical products and injectable solutions; biological preparations for monitoring sterilization processes other than for medical or veterinary use Scientific, weighing, measuring, and checking apparatus and instruments in the nature of automated laboratory sample preparation and filtration apparatus for testing the sterility of pharmaceutical and radiopharmaceutical products, injectable solutions and medical and surgical equipment, for scientific use; scientific, weighing, measuring, and checking apparatus and instruments in the nature of automated laboratory sample preparation and filtration apparatus for testing the sterility of apparatus and instruments for conducting quality checks in pharmaceutical chemistry, radiopharmacy and nuclear medicine, and for testing the sterility of apparatus and instruments for production, distribution, handling and analysis for medical or non-medical use of chemical, pharmaceutical, radiopharmaceutical products and radioactive materials, all for scientific use; scientific, weighing, measuring, and checking apparatus and instruments in the nature of automated laboratory sample preparation and filtration apparatus for testing the sterility of apparatus for analysis for medical or non-medical use, testing the sterility of scientific apparatus and instruments for synthesizing chemical products for medical or non-medical use, testing the sterility of scientific apparatus and instruments for treating radioactive materials for medical or non-medical use, and testing the sterility of laboratory instruments for medical or non-medical use, all for scientific use; downloadable computer software for analyzing, viewing and transmitting sterility testing data for medical equipment, pharmaceutical and radiopharmaceutical products and injectable solutions; recorded computer software for analyzing, viewing and transmitting sterility testing data for medical equipment, pharmaceutical and radiopharmaceutical products and injectable solutions; downloadable computer software for analyzing, viewing and transmitting medical data Analytical scientific laboratory services; quality control for others and testing of pharmaceutical and radiopharmaceutical products and injectable solutions; quality control for others, namely, sterility testing services for pharmaceutical and radiopharmaceutical products and injectable solutions; laboratory research services concerning pharmaceutical and radiopharmaceutical products; testing and analysis of materials; medical research, namely, medicine testing services; testing of chemicals; chemical analysis and evaluation services; detection of contaminants in medicine, namely, sampling and analysis to determine the presence of contamination; research and development concerning chemical reagents and scientific apparatus and instruments in the field of testing and quality control
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
apparatus for the administration of medicines, namely, drug delivery catheters and dosage dispensers for administering medicine to patients; automatic medical apparatus for dose injection for humans; metering pumps for administering medicines in measured quantities for medical use; infusion pumps for administering medicines; intravenous infusion pumps for medical use; dosage dispensers for administering medicine to patients, for medical use; medical apparatus for administering medical fluids for the administration of radiopharmaceuticals and disposable medical syringes for use therewith; apparatus for administering contrast agents for medical use; infusion apparatus for therapeutic purposes, namely, infusion lines; infusion apparatus for therapeutic purposes, namely, infusion columns; hypodermic needles for infusion therapy; medical syringes; multishot needle medical syringes; syringe needles for medical use; disposable medical needles for hypodermic syringes; syringe pushers for medical use; valves being component replacement parts for medical infusion instruments for administering drugs; catheters; tubes for use with catheters; protectors for catheters being parts and fittings for catheters; transfusion tubes being medical tubing for transfusion; intravenous feeding tubes; tubing for medical transfusion use; medical instruments for therapeutic monitoring of medicinal treatments; sensors for medical use for monitoring patients' vital signs; structures for protection against radiation for medical use, namely, patient x-ray radiation shields Maintenance, adjustment being repair and repair of surgical and medical apparatus and instruments, in particular apparatus for administering drugs and fluids for medical use Design and development of medical technologies; design and development of medical diagnostic apparatus and drug and fluid delivery apparatus for medical use; calibration services relating to medical equipment; computer program writing services for medical applications; design and development of software for use in the framework of medical technology.
The present invention relates to a method for stabilizing the production yield of [18F]-labelled radiotracers by the addition of a radical scavenger in the reaction media of the nucleophilic [18F]-fluorination step.
C07H 5/02 - Composés contenant des radicaux saccharide dans lesquels les liaisons carbone-oxygène ont été remplacées par le même nombre de liaisons carbone-hétéro-atomes à des atomes d'halogènes, d'azote, de soufre, de sélénium ou de tellure à des halogènes
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, optical, weighing, measuring, checking
(supervision) apparatus and instruments for conducting
quality controls in pharmaceutical chemistry, radiopharmacy
and nuclear medicine; apparatus and instruments for the
production, distribution, manipulation and analysis not for
medical use of chemical and pharmaceutical products and
radioactive materials; testing apparatus not for medical
use; scientific apparatus and instruments for synthesizing
chemical products not for medical use; scientific apparatus
and instruments for the treatment of radioactive materials
not for medical use; laboratory instruments, other than for
medical use; dosimeters; computer software; computer
software for analyzing, viewing and transmitting medical
data. Apparatus and instruments for the production, distribution,
manipulation and analysis for medical use of chemical and
pharmaceutical products and radioactive materials; medical
monitors and analyzers; testing apparatus for medical use;
apparatus and instruments for synthesizing chemical products
for medical use; apparatus and instruments for the treatment
of radioactive materials for medical use; instruments for
medical use; diagnostic apparatus and instruments; apparatus
for the administration of medicines; automatic medical
apparatus for dose injection for humans; metering pumps for
administering medicines in measured quantities for medical
use; infusion pumps for administering medicines; intravenous
infusion pumps for medical use; dosage dispensers for
medical use; apparatus for administering medical fluids for
the administration of radiopharmaceuticals and disposable
products for use therewith; apparatus for administering
contrast agents for medical use; infusion lines; infusion
columns; hypodermic needles for infusion therapy; medical
syringes; multishot needle syringes; syringe needles for
medical use; disposable needles for hypodermic syringes;
syringe pushers for medical use; valves intended for use in
medical infusion instruments; catheters; tubes for
catheters; protectors for catheters; transfusion tubes;
intravenous feeding tubes; tubing for medical use; medical
instruments for therapeutic monitoring of medicinal
treatments; sensors for medical use for monitoring patients'
vital signs; structures for protection against radiation for
medical use. Maintenance, calibration, recalibration, adjustment and
repair of surgical and medical apparatus and instruments,
including apparatus for administering drugs and fluids for
medical use. Scientific and technological services as well as research
and design services relating thereto in the fields of
radiopharmacy, production, distribution, handling and
analysis of chemicals and pharmaceuticals and radioactive
materials; technical research in the fields of
radiopharmacy, production, distribution, handling and
analysis of chemical and pharmaceutical products and
radioactive materials; research and development services in
the fields of radiopharmacy, production, distribution,
handling and analysis of chemical and pharmaceutical
products and radioactive materials; design and development
of medical technologies; design and development of medical
diagnostic apparatus and drug and fluid delivery apparatus
for medical use; calibration services relating to medical
equipment; computer program writing services for medical
applications; design and development of software for use in
the framework of medical technology.
The present invention relates to a device (1) for performing a quantitative liquid transfer from a crimp capped vial (12) to another vial, container or a cassette, said device (1) comprising a component (100) made of: - a lower cylindrical part (101) with a beveled cylindrical notch, able to receive in tight insertion a crimp capped vial (12), said notch having an aperture (2) on a side of the lower cylindrical part (101); - an upper cylindrical part (102) in communication with the lower cylindrical part (101) and comprising a hollow cylindrical protrusion (3) for guiding the extension tube (13) equipped with a spike (7), a groove (4) being provided in said upper cylindrical part (102) for keeping the extension tube (13) in place during the handling of said device(1); - a central cylindrical part (103), provided between the lower and the upper cylindrical parts (101, 102), comprising a furrow (5) to ensure a correct positioning of the extension tube (13) during the transfer of the fluid to another vial, container or a cassette, a round rail (6, 6') being provided on each side of the central cylindrical part (103) allowing the shielded pot (11) and its lid (10) to be respectively anchored on said component (100); said aperture (2) being extended in the respective central and upper cylindrical parts (103, 102) and said spike (7) being connected to a luer lock ring (8).
The present invention relates to a method for synthesizing an aluminium- fluoride complex by reacting together: - a salt made of aluminium(III) and counterions other than chloride(I), and a fluoride anion; or - a chelate bearing molecule precomplexed with aluminium (III), obtained from treating said chelate bearing molecule with a salt made of aluminium(III) and counterions other than chloride(I), and a fluoride anion; said fluoride being [19F]fluoride or radioactive [18F]fluoride.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Appareils et instruments scientifiques, optiques, de pesage, de mesurage, de contrôle (inspection), nommément, appareils de chromatographie pour usage en laboratoire, pour la chromatographie liquide, la chromatographie gazeuse, la chromatographie en couche mince, spectromètres optiques, spectromètres pour la radiation gamma, pH-mètres, conductimètres pour la réalisation de contrôles de qualité en chimie pharmaceutique, en radiopharmacie et en médecine nucléaire; appareils et instruments pour la production, la distribution, la manipulation et l'analyse non à usage médical de produits chimiques et pharmaceutiques et de matières radioactives, nommément, membranes de filtration utilisées à des fins scientifiques, à savoir les filtres de laboratoire utilisés dans les équipements de laboratoire de l'industrie pharmaceutique, pour le traitement chimique, compteurs Geiger, dosimètres, dispositifs automatisés pour la synthèse radiochimique de traceurs destinés à la tomographie par émission de positons (TEP) et à la tomographie par émission monophotonique (TEMP); appareils pour l'analyse non à usage médical, nommément, appareils de chromatographie de laboratoire, pH-mètres, détecteurs de gaz, scanners au phosphore pour radiographie informatisée, non à usage médical; appareils et instruments scientifiques pour synthétiser des produits chimiques non à usage médical, nommément, appareil de dépôt chimique en phase vapeur pour une utilisation dans la recherche scientifique en laboratoire, appareil de réacteur de liquéfaction hydrothermique; appareils et instruments scientifiques destinés au traitement de matières radioactives non à usage médical, nommément, détecteurs de rayonnement, gamma-caméras, autres qu'à usage médical; instruments de laboratoire autres qu'à usage médical, nommément, entonnoirs de laboratoire, supports pour pipettes de laboratoire, couveuses de laboratoire, bioréacteurs pour usage en laboratoire, fours de chauffage spécialement conçus pour expériences de laboratoire; doseurs, nommément, distributeurs de dosage de portions prédéfinies de fluides non destinés à un usage médical; logiciels informatiques, nommément, logiciels téléchargeables pour accéder et utiliser des bases de données dans le domaine de la radiopharmacie; logiciels informatiques pour analyser, visualiser et transmettre des données médicales.
(2) Appareils et instruments pour la production, la distribution, la manipulation et l'analyse à usage médical de produits chimiques et pharmaceutiques et de matières radioactives, nommément, tomodensitomètres, dispositifs médicaux pour la dosimétrie dans le domaine de la radiothérapie, distributeurs de doses à usage médical, appareils de radiographie à usage médical, appareils de tomographie par résonance magnétique [TRM], écrans blindés et conteneurs blindés pour la manipulation sécuritaire de matières radioactives; moniteurs et analyseurs médicaux, nommément, moniteurs de concentration d'analytes dans le sang, analyseur de fluides corporels à des fins médicales, analyseur électrique quantique à résonance magnétique à des fins de diagnostic médical, analyseurs de composition corporelle à usage médical, plaques de micro-tests de diagnostic à usage médical; appareils pour l'analyse à usage médical, nommément, analyseur de fluides corporels à des fins médicales, appareil de mesure de la concentration d'analytes dans le sang; appareils et instruments pour synthétiser des produits chimiques à usage médical, nommément, instruments de préparation d'échantillons protéomiques pour le diagnostic médical, filtres en temps réel en tant que parties de caméras à rayons X à usage médical; appareils et instruments destinés au traitement de matières radioactives à usage médical, nommément, dispositifs automatisés pour la synthèse radiochimique de traceurs destinés à la tomographie par émission de positons (TEP) et à la tomographie par émission monophotonique (TEMP), ainsi que des distributeurs de doses pour administrer des médicaments aux patients; instruments à usage médical, nommément, instruments chirurgicaux, instruments médicaux pour examen général; appareils et instruments pour le diagnostic, nommément, appareils de diagnostic par imagerie par résonance magnétique (IRM), appareils de diagnostic médical par ultra-sons, gamma-caméras à usage médical, densitomètres à usage médical, hémoglobinomètres, doigtiers pour le diagnostic; appareils pour l'administration de médicaments, nommément, compte-gouttes pour l'administration de médicaments, cathéters pour l'administration de médicaments, nébuliseurs à usage médical, appareils médicaux pour faciliter l'inhalation de préparations pharmaceutiques; appareils médicaux automatiques pour injection de doses aux humains, nommément, injecteurs à usage médical, dispositif implantable d'administration de médicaments; pompes doseuses pour l'administration de médicaments en quantités mesurées à usage médical; pompes à perfusion pour administrer des médicaments; pompes à perfusion intraveineuse à usage médical; distributeurs-doseurs à usage médical; appareil pour l'administration de fluides médicaux pour l'administration de produits radiopharmaceutiques et produits jetables à utiliser avec ces produits, nommément, appareils médicaux pour l'administration intraveineuse de fluides, nommément, réchauffeurs de fluides, raccords pour fluides médicaux, robinets d'arrêt à trois voies pour usage médical, seringues à usage médical; appareils pour l'administration d'agents de contraste à usage médical, nommément, pompes implantables pour l'administration de médicaments; tubes de perfusion; colonnes de perfusion; aiguilles hypodermiques destinées à la thérapie par perfusion; seringues médicales; seringues à aiguilles pour injections multiples; aiguilles pour seringues à usage médical; aiguilles jetables pour seringues hypodermiques; pousse-seringues à usage médical; valves destinées à des instruments médicaux de perfusion; cathéters; tubes pour cathéters; protections pour cathéters, nommément, dispositifs médicaux pour la pose et la fixation de cathéters; tubes de transfusion; tubes d'alimentation intraveineuse; tubulures à usage médical; instruments médicaux pour la surveillance thérapeutique de traitements médicamenteux, nommément, instruments médicaux pour le prélèvement d'échantillons de sang humain, de cellules, de salive, d'urine et de crachats à usage médical; capteurs à usage médical pour la surveillance des constantes vitales des patients; écrans de protection contre les radiations à usage médical. (1) Services de maintenance, calibrage, recalibrage, ajustement et réparation d'appareils et instruments chirurgicaux et médicaux, y compris appareils pour l'administration de médicaments et de fluides à usage médical.
(2) Services de recherche scientifique et technologique dans les domaines la radiopharmacie, de la production, la distribution, la manipulation et l'analyse de produits chimiques et pharmaceutiques et de matières radioactives; recherche technique dans les domaines de la radiopharmacie, de la production, la distribution, la manipulation et l'analyse de produits chimiques et pharmaceutiques et de matières radioactives; services de recherche et développement dans les domaines de la radiopharmacie, de la production, la distribution, la manipulation et l'analyse de produits chimiques et pharmaceutiques et de matières radioactives; conception et développement de technologies médicales; conception et développement d'appareils de diagnostic médical et d'appareils d'administration de médicaments et de fluides à usage médical; services d'étalonnage relatifs au matériel médical; services d'écriture de programmes informatiques pour applications médicales; conception et développement de logiciels destinés à être utilisés dans le cadre de technologies médicales.
09 - Appareils et instruments scientifiques et électriques
10 - Appareils et instruments médicaux
37 - Services de construction; extraction minière; installation et réparation
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific, optical, weighing, measuring, checking apparatus and instruments for conducting quality controls in pharmaceutical chemistry, radiopharmacy and nuclear medicine, namely, integrated quality control devices for streamlining and automating the quality control of positron emission tomography tracers; apparatus and instruments for the production, distribution, manipulation and analysis not for medical use of chemical and pharmaceutical products and radioactive materials, namely, automated devices for the radiochemical synthesis of positron emission tomography and single-photon emission computerized tomography tracers, and mechanical devices, namely, dispensers of preset portions of fluids, solid granules and powder for dosing purposes, all not for medical use; radioprotection devices, namely, hot cells for handling radioactive materials safely, shielded screen and shielded containers for handling radioactive materials safely; scientific apparatus and instruments for synthesizing chemical products not for medical use, namely, automated devices for the radiochemical synthesis of positron emission tomography and single-photon emission computerized tomography tracers; scientific apparatus and instruments for the treatment of radioactive materials not for medical use, namely, automated devices for the radiochemical synthesis of positron emission tomography and single-photon emission computerized tomography tracers and mechanical devices, namely, dispensers of preset portions of fluids, solid granules and powder for dosing purposes, all not for medical use; dosimeters; downloadable computer software for a centralized control software platform designed to control and monitor all automated systems involved in the production and quality control of radiopharmaceuticals; downloadable computer software for analyzing, viewing and transmitting medical data Apparatus and instruments for the production, distribution, manipulation and analysis for medical use of chemical and pharmaceutical products and radioactive materials, namely, automated devices for the radiochemical synthesis of positron emission tomography and single-photon emission computerized tomography tracers, dosage dispensers for administering medicine to patients, integrated quality control devices for streamlining and automating the quality control of positron emission tomography tracers; apparatus and instruments for synthesizing chemical products for medical use, namely, automated devices for the radiochemical synthesis of positron emission tomography and single-photon emission computerized tomography tracers; apparatus and instruments for the treatment of radioactive materials for medical use, namely, automated devices for the radiochemical synthesis of positron emission tomography and single-photon emission computerized tomography tracers and dosage dispensers for administering medicine to patients; apparatus for the administration of medicines, namely, drug delivery catheters and dosage dispensers for administering medicine to patients; automatic medical apparatus for dose injection for humans in particular medical syringes and medical fluid injectors; metering pumps for administering medicines in measured quantities for medical use; infusion pumps for administering medicines; intravenous infusion pumps for medical use; dosage dispensers for medical use, namely, dosage dispensers for administering medicine to patients; apparatus for administering medical fluids for the administration of radiopharmaceuticals and disposable medical syringes for use therewith; apparatus in the nature of infusion pumps for administering contrast agents for medical use; infusion lines being infusion devices for administering drugs; infusion columns being infusion devices for administering drugs; hypodermic needles for infusion therapy; medical syringes; multishot needle medical syringes; syringe needles for medical use; disposable medical needles for hypodermic syringes; syringe pushers for medical use; valves being component replacement parts for medical infusion instruments for administering drugs; catheters; tubes being parts for catheters; protectors being parts specially adapted for catheters; transfusion medical tubing; intravenous feeding tubes; tubing for medical transfusion use; medical instruments for therapeutic monitoring of medicinal treatments; sensors for medical use for monitoring patients' vital signs; structures for protection against radiation for medical use, namely, patient x-ray radiation shields Maintenance, adjustment being repair and repair of medical apparatus and instruments, in particular apparatus for administering drugs and fluids for medical use Scientific and technological services as well as research and design services relating thereto, namely, scientific research in the fields of radiopharmacy, production, distribution, handling and analysis of chemicals and pharmaceuticals and radioactive materials; scientific research in the fields of radiopharmacy, production, distribution, handling and analysis of chemical and pharmaceutical products and radioactive materials; scientific research and development services in the fields of radiopharmacy, production, distribution, handling and analysis of chemical and pharmaceutical products and radioactive materials; design and development of medical technological devices; design and development of computer hardware for medical diagnostic apparatus and drug and fluid delivery apparatus for medical use; calibration services relating to medical equipment
ABSTRACT The present invention relates, in one embodiment, to a device (4) for reversibly coupling a syringe (5) to an actuator (3), the device comprising an inner body (41) having a longitudinal axis and an outer sleeve (46) capable of moving relative to the inner body (41) along the longitudinal axis, the inner body (41) comprising a sliding axis terminated by a slack adjusting plate (42) held longitudinally inside the inner body (41) in a rest position by a preloaded spring (43) and at least one pair of hooks (44) arranged longitudinally inside the inner body (41) mounted so as to pivot and retract in pairs around two respective axes (47) perpendicular to the longitudinal axis, an outer portion of the hooks (44) and an inner portion of the sleeve (46), the outer portion facing the inner portion having respective profiles (50, 51) configured such that sliding the sleeve (46) relative to the inner body (41) in a direction away from the hooking regions of the hooks (44) causes the hooks (44) to open, upon contact with the profiles (50, 51), by pivoting about their respective pivot axes (47).
The present invention relates, in one embodiment, to a device (4) for reversibly coupling a syringe (5) to an actuator (3), the device comprising an inner body (41) having a longitudinal axis and an outer sleeve (46) capable of moving relative to the inner body (41) along the longitudinal axis, the inner body (41) comprising a sliding axis terminated by a slack adjusting plate (42) held longitudinally inside the inner body (41) in a rest position by a preloaded spring (43) and at least one pair of hooks (44) arranged longitudinally inside the inner body (41) mounted so as to pivot and retract in pairs around two respective axes (47) perpendicular to the longitudinal axis, an outer portion of the hooks (44) and an inner portion of the sleeve (46), the outer portion facing the inner portion having respective profiles (50, 51) configured such that sliding the sleeve (46) relative to the inner body (41) in a direction away from the hooking regions of the hooks (44) causes the hooks (44) to open, upon contact with the profiles (50, 51), by pivoting about their respective pivot axes (47).
A method for synthesis and purification of radiolabeled macroaggregated human serum albumin (MAA) to form a bulk solution injectable to a patient includes: providing a radiometal in a generator, the radiometal being a generator eluate; synthesizing the radiolabeled MAA in a reactor with MAA particles from a commercially available labeling kit for 99mTc and the generator eluate so as to provide synthesized radiolabeled MAA particles; passing the synthesized radiolabeled MAA particles on a syringe filter membrane having a membrane composition, diameter, and pore size for trapping the radiolabeled MAA particles as trapped radiolabeled MAA particles and not retaining impurities from a bulk solution, the impurities including free radioactive metal isotopes, parent radioactive metal breakthrough, and stannous chloride present in the MAA labeling kit for 99mTc; and untrapping the trapped radiolabeled MAA particles from the syringe filter using a saline or buffered solution passing through the syringe filter.
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
C07K 1/34 - ExtractionSéparationPurification par filtration, ultrafiltration ou osmose inverse
37.
METHOD FOR PURIFICATION OF RADIOLABELED MACROAGGREGATED HUMAN SERUM ALBUMIN
The present invention relates to a method for purifying radiolabelled human serum albumin macroaggregates (MAA) in a solution that can be injected into a patient using a syringe filter, characterized in that the syringe filter used has the property of trapping and releasing the radiolabelled MAA whilst the impurities of the total solution are not retained.
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
38.
METHOD FOR PURIFYING RADIOLABELLED HUMAN SERUM ALBUMIN MACROAGGREGATES
The present invention relates to a method for purifying radiolabelled human serum albumin macroaggregates (MAA) in a solution that can be injected into a patient using a syringe filter, characterized in that the syringe filter used has the property of trapping and releasing the radiolabelled MAA whilst the impurities of the total solution are not retained.
A61K 51/12 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo caractérisées par un aspect physique particulier, p. ex. émulsion, microcapsules, liposomes
39.
Device for preparing a liquid sample for a gas chromatograph
A device for preparing a liquid sample for a direct injection of a corresponding gaseous sample to a micro-gas chromatograph includes: a fluid space and a gas space, which spaces are separated by a semipermeable separating layer, the fluid space including a supply line for the liquid sample, and the gas space having an outlet connectable with the gas chromatograph. The fluid space and/or the gas space is associated with at least one heating element. The device absorbs a sample volume of approximately 10 μl to 30 μl. The separating layer has a thickness of 10 μl to 300 μl and pores having a size between 0.05 μl and 5 μl.
A stopcock manifold system includes: a manifold provided with one or several stopcocks, each having a rotary opening/closing control apparatus with at least one finger or crank pin; a rotary mechanized actuator coupling part for each manifold, a rotary axis of the coupling part corresponding in use to a rotation axis of the control apparatus, the coupling part coupling with the stopcock by insertion of each crank pin into a closed notch in the coupling part, the closed notch of each coupling part receiving one of the crank pins of the corresponding stopcock, such that the crank pin is insertable into the corresponding coupling part by tilting the manifold and then straightening it, until it abuts on a first bearing point comprised of an edge of the closed notch; and a maintaining system that enables each coupling part to individually maintain the corresponding stopcock in place.
F16K 31/52 - Moyens mécaniques d'actionnement à manivelle, excentrique ou came
F16K 5/04 - Robinets à boisseau consistant seulement en un dispositif obturateur dont au moins une des faces d'obturation a la forme d'une surface de solide de révolution plus ou moins complète, le mouvement d'ouverture et de fermeture étant essentiellement rotatif dont les boisseaux sont à surface cylindriqueLeurs garnitures d'étanchéité
F16K 11/22 - Soupapes ou clapets à voies multiples, p. ex. clapets mélangeursRaccords de tuyauteries comportant de tels clapets ou soupapesAménagement d'obturateurs et de voies d'écoulement spécialement conçu pour mélanger les fluides dont plusieurs éléments de fermeture ne se déplacent pas comme un tout actionnés par des organes de commande distincts chacun étant propre à une soupape, p. ex. conjugués pour former clapet à voies multiples
The invention relates to a plate (10) for thin-layer chromatography comprising a carrier plate (12), at least one elongated depression with a release agent (16) and a covering film (18) for the at least one elongated depression, which has an intermediate film (20), which is arranged between the carrier plate (12) and the covering film (18) and which comprises at least one elongated recess (14), in order to form the elongated depression, wherein the covering film (18) has at least one recess (22, 24, 26) for applying a solvent and a sample to the release agent (16). In this case, the at least one elongated recess (14) is assigned a reservoir (28) for the solvent. The plate (10) is particularly suitable for automated operation.
The invention relates to a device (30) for preparing a liquid sample for a gas chromatograph, comprising a liquid compartment (12) and a gas compartment (16) which are separated by a semipermeable separating layer (32), the liquid compartment (12) comprising a supply line (14) for the liquid sample, and the gas compartment (16) comprising an outlet (18) that can be connected to the gas chromatograph. A heating element (34) is associated with the liquid compartment (12). As a result of the interaction of the semipermeable separating layer (20) and the heating element (34), small quantities of the liquid sample can also be prepared.
The present invention relates to a stopcock manifold system comprising a manifold (7) having: one or more stopcocks (2) each comprising at least one finger or handle (4); for every stopcock (2), a connection element (5, 10) for connecting a mechanical actuator; and a retaining system designed to ensure that every connection element (5, 10) individually keeps the stopcocks (2) in place.
The present invention relates to a perforating needle (1) comprising: a pointed end (5) configured to pierce the stopper (6); a cylindrical body (3) comprising a central channel (11) through which the fluid (7) can enter and leave the vial (2), and a sidewall (12) comprising at least one lateral orifice (8), said orifice (8) being fluidically connected to the central channel (11), and the lower end of this orifice (8) being substantially level with the inner face of the stopper (6) during use; characterized in that said orifice (8) is continued towards the pointed end (5) by at least one slot (17), of which the shape is determined so as to be substantially tangential to the flow of the fluid (7), for the purpose of channelling it along the axis of the needle.
A61J 1/20 - Dispositions pour le transfert des liquides, p. ex. du flacon à la seringue
A61M 5/32 - AiguillesParties constitutives des aiguilles relatives au raccordement de celles-ci à la seringue ou au manchonAccessoires pour introduire l'aiguille dans le corps ou l'y maintenirDispositifs pour la protection des aiguilles
45.
Method for purification of 18F-labeled choline analogues
The present invention relates to a method for purification of 18F-labeled choline analogs in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogs.
18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.
C07C 227/12 - Formation de groupes amino et carboxyle
C07C 227/18 - Préparation de composés contenant des groupes amino et carboxyle liés au même squelette carboné à partir de composés contenant déjà des groupes amino et carboxyle ou leurs dérivés par des réactions impliquant des groupes amino ou carboxyle, p. ex. hydrolyse d'esters ou d'amides, par formation d'halogénures, de sels ou d'esters
47.
METHOD FOR PURIFICATION OF 18F-LABELED CHOLINE ANALOGUES
The present invention relates to a method for purification of 18F- labeled choline analogues in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogues.
The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.
The present invention is related to a method to obtain reactive [18F] fluorides in an organic medium suitable for radiolabelling without any azeotropic evaporation step, by the use of a solid phase extraction column containing a modified non-ionic solid support.
B01D 15/08 - Adsorption sélective, p. ex. chromatographie
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
B01D 15/42 - Adsorption sélective, p. ex. chromatographie caractérisée par le mode de développement, p. ex. par déplacement ou par élution
A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
C09K 11/04 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des éléments radioactifs naturels ou artificiels ou des éléments radioactifs non précisés
09 - Appareils et instruments scientifiques et électriques
Produits et services
Scientific, surveying, optical, weighing, measuring, signaling, checking and supervision apparatus and instruments, namely, chromatography apparatus, in particular for liquid chromatography, gas chromatography, thin layer chromatography, spectrometers, in particular optical spectrometers, spectrometers for gamma radiation, pH meters, conductivity meters, dispensers of preset portions of fluids for dosing purposes not for medical use, calibration devices for calibrating the dosing of radioactive radiation not for medical use, a device having a liquid chromatograph, a gas chromatograph, a thin layer chromatograph, an optical spectrometer, a gamma-spectrometer, a ph-meter, a conductivity meter, a dispenser of preset portions of fluid, and a calibration device for calibrating the dosing of radioactive radiation; data processing equipment; all aforementioned goods for processing quality controls in the area of pharmaceutical chemistry, in particular with respect to radiopharmaceuticals
51.
METHOD FOR THE DIRECT ELUTION OF REACTIVE 18F FLUORIDE FROM AN ANION EXCHANGE RESIN IN AN ORGANIC MEDIUM SUITABLE FOR RADIOLABELLING WITHOUT ANY EVAPORATION STEP BY THE USE OF STRONG ORGANIC BASES
The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step characterised in that the eluting solution is a organic solution having a water content <3%, containing at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
52.
METHOD FOR THE PREPARATION OF REACTIVE [18] F FLUORIDE
The present invention is related to a method to obtain reactive [18F] fluorides in an organic medium suitable for radiolabelling without any azeotropic evaporation step, by the use of a solid phase extraction column containing a modified non- ionic solid support.
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
53.
METHOD FOR THE ELUTION OF 18F FLUORIDE TRAPPED ON AN ANION-EXCHANGE PHASE IN A FORM SUITABLE FOR EFFICIENT RADIOLABELING WITHOUT ANY EVAPORATION STEP
The present invention relates to a method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step, characterised in that the eluting solution is a low water content, preferably ឬ3% water, organic solution containing at least: a first compound (A) which is a tertiary alcohol-function bearing molecule, a second compound (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process.
C22B 3/42 - Traitement ou purification de solutions, p. ex. de solutions obtenues par lixiviation par extraction utilisant l'échange d'ions
G21G 1/10 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p. ex. production d'isotopes radioactifs à l'extérieur des réacteurs nucléaires ou des accélérateurs de particules par bombardement avec des particules électriquement chargées
A61K 51/00 - Préparations contenant des substances radioactives utilisées pour la thérapie ou pour l'examen in vivo
B01D 15/36 - Adsorption sélective, p. ex. chromatographie caractérisée par le mécanisme de séparation impliquant une interaction ionique, p. ex. échange d'ions, paire d'ions, suppression d'ions ou exclusion d'ions
C07B 59/00 - Introduction d'isotopes d'éléments dans les composés organiques
54.
ELECTROCHEMICAL 18F EXTRACTION, CONCENTRATION AND REFORMULATION METHOD FOR RADIOLABELING
The present invention relates to a method to extract out of water, concentrate and reformulate [18F] fluorides, said method comprising the successive steps of : - passing a dilute aqueous [18F] fluoride solution entering by an inlet (1) in a cavity (6) embodying an electrochemical cell with at least two electrodes (3, 4, 5), flowing in the cavity (6) and coming out of the cavity (6) by an outlet (2), an external voltage being applied to said electrodes, one electrode (4) being used as an extraction electrode, another one (3) being used for polarizing the solution, and configured so that at least the extraction electrode (4), either used as a cathode or as an anode, is in contact with and polarizes a large specific surface area conducting material (7), contained in the cavity (6); - releasing the extracted ions from the surface of the large specific surface area conducting material (7) by turning off the applied external voltage, wherein, during its passage in the cavity (6), the dilute aqueous [18F] fluoride solution entirely crosses and internally soaks the large specific surface area conducting material (7).
