05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
Produits et services
Dietary and nutritional supplements; medicinal beverages;
preparations for use as energy-providing additives to food
and drink for human consumption. Coffee drinks; tea drinks; coffee-based drinks; tea-based
drinks; coffee flavourings; tea flavourings; coffee
concentrates; tea concentrates; coffee mixtures; tea
mixtures; fruit teas; fruit infusions. Non-alcoholic beverages; coffee-flavoured soft drinks;
tea-flavoured soft drinks; energy drinks; fruit drinks;
fruit juices; concentrates for use in the preparation of
energy drinks and fruit drinks; sports drinks enhanced with
vitamins, minerals or nutrients; syrups, concentrates and
other preparations for making non-alcoholic beverages.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
Produits et services
Dietary and nutritional supplements; medicinal beverages; preparations for use as energy-providing additives to food and drink for human consumption. Coffee drinks; tea drinks; coffee-based drinks; tea-based drinks; coffee flavourings; tea flavourings; coffee concentrates; tea concentrates; coffee mixtures; tea mixtures; fruit teas; fruit infusions. Non-alcoholic beverages; coffee-flavoured soft drinks; tea-flavoured soft drinks; energy drinks; fruit drinks; fruit juices; concentrates for use in the preparation of energy drinks and fruit drinks; sports drinks enhanced with vitamins, minerals or nutrients; syrups, concentrates and other preparations for making non-alcoholic beverages.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
Produits et services
Dietary and nutritional supplements; medicinal beverages;
preparations for use as energy-providing additives to food
and drink for human consumption. Coffee, tea, cocoa and substitutes therefor; coffee drinks;
tea drinks; coffee flavourings; tea flavourings; coffee
concentrates; tea concentrates; coffee mixtures; tea
mixtures; ketone precursors additives. Non-alcoholic beverages; coffee-flavoured soft drinks;
tea-flavoured soft drinks; energy drinks; concentrates for
use in the preparation of energy drinks; sports drinks
enhanced with vitamins, minerals or nutrients; syrups and
other preparations for making non-alcoholic beverages.
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Coffee, tea, cocoa and substitutes therefor; coffee drinks; tea- based drinks; coffee flavourings, other than essential oils; tea flavourings, other than essential oils; coffee concentrates, namely, coffee extracts; tea concentrates, namely, tea extracts; coffee mixtures, namely, instant coffee, and mixtures of coffee essences and coffee extracts; tea mixtures; ketone precursors additives, namely, food flavorings other than essential oils Non-alcoholic beverages, namely, soft drinks; coffee-flavoured soft drinks; tea-flavoured soft drinks; energy drinks; concentrates for use in the preparation of energy drinks; sports drinks enhanced with vitamins, minerals or nutrients; syrups and other preparations for making non-alcoholic beverages, namely, syrups and concentrates for making soft drinks Dietary and nutritional supplements; medicinal beverages, namely, dietetic beverages adapted for medical purposes; preparations for use as energy-providing additives to food and drink for human consumption, namely, food and drink nutritional supplements
or a pharmaceutically acceptable salt or solvate thereof. The invention also provides a method of administering such a compound in a dosage effective to reduce hunger in order that a cosmetically beneficial loss or maintenance of body weight occurs, wherein in the method, plasma ghrelin levels are lowered. The aforementioned compound is also provided for use in a method of treatment of the human or animal body wherein the compound is administered and hunger is suppressed by lowering of plasma ghrelin levels. The compound is particularly useful for subjects having conditions associated with over-eating, such as overweight, obese, severely obese patients or diabetic patients.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
(1) Dietary supplement drinks and drink mixes for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; vitamin supplement drinks; dietary and nutritional supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, dietary and nutritional preparations for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary meal replacements namely nutritional supplement meal replacement beverages for boosting energy, vitamin preparations in the form of meal replacement drinks and powders; weight loss preparations in the nature of weight loss powders and gels; powdered nutritional supplements namely protein powders for meal replacement for use as a dietary supplement; fitness and endurance dietary and nutritional supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, all the aforesaid containing a ketone ester and beta-hydroxybutyrate; non-medicated non-alcoholic-based sports and energy drinks for the treatment of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans and animals, all the aforementioned containing a ketone ester and beta-hydroxybutyrate; nutritionally fortified beverages containing a ketone ester and beta-hydroxybutyrate for boosting energy, providing athletic support, nutrition replacement, and for general health and well-being
(2) Non-alcoholic drinks namely energy drinks, protein enriched sports drinks, fruit drinks and juice drinks containing caloric substitutes for carbohydrates and used to maintain, promote and enhance fitness; non-alcoholic fruit beverages, isotonic beverages, sports drinks, vitamin fortified non-alcoholic beverages, all the aforesaid containing a ketone ester and beta-hydroxybutyrate; syrups and other non-alcoholic preparations namely non-alcoholic fruit extracts for making beverages containing a ketone ester and betahydroxybutyrate
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages; medicinal drinks; medicated health
drinks; dietary supplement drinks and drink mixes;
preparations for making medicated beverages; herbal
beverages for medicinal use; vitamin drinks; tonics; dietary
and nutritional supplements, dietary and nutritional
preparations; dietary meal replacements; dietary food
supplements; weight loss preparations; powdered nutritional
supplements; fitness and endurance supplements; all the
aforesaid containing ketone esters or hydroxybutyrates. Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks; recovery drinks; fruit beverages;
isotonic beverages; nutritionally fortified non-alcoholic
beverages; vitamin fortified non-alcoholic beverages;
waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
Non-alcoholic drinks and gels other than milk products and
those having a coffee, tea or cocoa base; beers; fruit
drinks and fruit juices; syrups and other preparations for
making non-alcoholic drinks other than milk products and
those having a coffee, tea or cocoa base; non-alcoholic
drinks, gels or beverages, and preparations for making
beverages containing or used in combination with ketone body
esters, in particular hydroxybutyrates and/or mid-chain
triglycerides; energy drinks and gels; non-alcoholic drinks
or beverages containing components for reducing fatigue, for
increasing muscle function efficiency or for raising blood
ketone levels in the human or animal body; drinks and energy
drinks containing ketone body esters in particular
hydroxybutyrates and/or mid-chain triglycerides.
Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks; recovery drinks; fruit beverages;
isotonic beverages; nutritionally fortified non-alcoholic
beverages; vitamin fortified non-alcoholic beverages;
waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
(1) Dietetic beverages for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary supplement drinks and drink mixes for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; preparations for making beverages for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietetic beverages for promoting weight loss, maintenance of healthy joints, and anti-ageing purposes; vitamin drinks; tonics for boosting energy, to increase athletic endurance, for nutrition replacement, and for general health and well-being; dietary and nutritional supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, dietary and nutritional preparations for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary meal replacements namely nutritional supplement meal replacement beverages for boosting energy, vitamin preparations in the form of meal replacement drinks and powders; dietary food supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; weight loss preparations in the nature of weight loss powders and gels; powdered nutritional supplements namely protein powders for meal replacement for use as a dietary supplement; fitness and endurance supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, all the aforesaid containing ketone esters and hydroxybutyrates
(2) Non-alcoholic drinks namely energy drinks, protein enriched sports drinks, fruit drinks and juice drinks containing caloric substitutes for carbohydrates and used to maintain, promote and enhance fitness; energy drinks; sports drinks; performance drinks; recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified non-alcoholic beverages namely non-alcoholic beverages enhanced with vitamins, minerals, nutrients, amino acids and herbs, vitamin fortified non-alcoholic beverages, waters, syrups, powders, concentrates and other non-alcoholic preparations namely non-alcoholic fruit extracts for making beverages, all the aforesaid drinks and preparations containing ketone esters and hydroxybutyrates
11.
Compounds for use in preventing or treating athlete overtraining
The present invention provides a compound for use in preventing or treating overtraining in a subject, wherein the compound is selected from (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer obtainable by oligomerising (R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof.
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine
A61K 31/23 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'acides ayant un groupe carboxyle lié à une chaîne d'au moins sept atomes de carbone
Non-alcoholic drinks and gels other than milk products and
those having a coffee, tea or cocoa base; when containing or
used in combination with ketone body esters in particular
hydroxybutyrates and/or mid-chain triglycerides (terms too
vague in the opinion of the International Bureau - Rule 13
(2) (b) of the Regulations); beers; fruit drinks and fruit
juices when containing or used in combination with ketone
body esters in particular hydroxybutyrates and/or mid-chain
triglycerides; syrups and other preparations for making
non-alcoholic drinks other than milk products and those
having a coffee, tea or cocoa base when containing or used
in combination with ketone body esters in particular
hydroxybutyrates and/or mid-chain triglycerides;
non-alcoholic drinks, gels or beverages any of the above
foodstuffs and preparations made from them when containing
or used in combination with ketone body esters in particular
hydroxybutyrates and/or mid-chain triglycerides and energy
drinks and gels; non- alcoholic drinks or beverages
containing components for preventing, treating or aiding
recovery from fatigue, for increasing muscle function
efficiency or for raising blood ketone levels in the human
or animal body; ices, drinks or including energy ices and
energy drinks when containing ketone body esters in
particular hydroxybutyrates and/ or mid-chain triglycerides.
1 is a moiety derived from an alcohol HORI, wherein said alcohol is a sugar. Typically, the invention also provides treatment of the conditions associated with cachexia, such as muscle wasting.
A23L 33/00 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement
A23L 33/115 - Acides gras ou leurs dérivésGraisses ou huiles
A23L 33/125 - Modification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sirops d'hydrate de carboneModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des sucresModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des alcools de sucreModification de la qualité nutritive des alimentsProduits diététiquesLeur préparation ou leur traitement en utilisant des additifs contenant des hydrolysats d'amidon
A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
The present invention provides a compound for use in preventing or treating multiple sclerosis in a subject, wherein the compound is selected from: (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer obtainable by oligomerising (R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof.
Non-alcoholic drinks and gels other than milk products and
those having a coffee, tea or cocoa base; beers; fruit
drinks and fruit juices; syrups and other preparations for
making non-alcoholic drinks other than milk products and
those having a coffee, tea or cocoa base; non-alcoholic
drinks, gels or beverages any of the above foodstuffs and
preparations made from them when containing or used in
combination with ketone body esters in particular
hydroxybutyrates and/or mid-chain triglycerides and energy
drinks and gels; non-alcoholic drinks or beverages
containing components for preventing, treating or aiding
recovery from fatigue, for increasing muscle function
efficiency or for raising blood ketone levels in the human
or animal body; ices, drinks or including energy ices and
energy drinks when containing ketone body esters in
particular hydroxybutyrates and/or mid-chain triglycerides.
Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks; recovery drinks; fruit beverages;
isotonic beverages; nutritionally fortified non-alcoholic
beverages; vitamin fortified non-alcoholic beverages;
waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks; recovery drinks; fruit beverages;
isotonic beverages; nutritionally fortified non-alcoholic
beverages; vitamin fortified non-alcoholic beverages;
waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages adapted for medical use; medicinal drinks; health medicinal drinks; dietary supplements in the form of drinks and drink mixes; preparations for making medicinal drinks; nutritionally fortified herbal beverages for medical purposes; Dietary supplemental drinks in the nature of vitamin drinks; tonics, namely, medicinal drinks; dietary and nutritional supplements, dietary and nutritional supplement preparations; dietary meal replacements, namely, nutritionally fortified beverages for medical purposes and nutritional supplement meal replacement bars, powders and gels for boosting energy; dietary food supplements; weight loss preparations, namely, dietary and nutritional supplements used for weight loss; powdered nutritional supplements; fitness and endurance nutritional supplements Non-alcoholic drinks, namely, energy shots and carbonated drinks; energy drinks; sports drinks; performance sports drinks; recovery sports drinks; fruit beverages; isotonic beverages; nutritionally fortified non-alcoholic water-based and fruit-based beverages; vitamin fortified non-alcoholic water-based and fruit-based beverages; drinking waters; syrups for beverages, powders, concentrates and non-alcoholic preparations used in the preparation of soft drinks
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages adapted for medical use; medicinal drinks; health medicinal drinks; dietary supplements in the form of drinks and drink mixes; preparations for making medicinal drinks; nutritionally fortified herbal beverages for medical purposes; Dietary supplemental drinks in the nature of vitamin drinks; tonics, namely, medicinal drinks; dietary and nutritional supplements, dietary and nutritional supplement preparations; dietary meal replacements, namely, nutritionally fortified beverages for medical purposes and nutritional supplement meal replacement bars, powders and gels for boosting energy; dietary food supplements; weight loss preparations, namely, dietary and nutritional supplements used for weight loss; powdered nutritional supplements; fitness and endurance nutritional supplements Non-alcoholic drinks, namely, energy shots and carbonated drinks; energy drinks; sports drinks; performance sports drinks; recovery sports drinks; fruit beverages; isotonic beverages; nutritionally fortified non-alcoholic water-based and fruit-based beverages; vitamin fortified non-alcoholic water-based and fruit-based beverages; drinking waters; syrups for beverages, powders, concentrates and non-alcoholic preparations used in the preparation of soft drinks
Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks; recovery drinks; fruit beverages;
isotonic beverages; nutritionally fortified non-alcoholic
beverages; vitamin fortified non-alcoholic beverages;
waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages for medical use; medicinal drinks; health
drinks for medical use; dietary supplement drinks and drink
mixes; preparations for making medicated beverages; herbal
beverages for medicinal use; vitamin drinks; tonics; dietary
and nutritional supplements, dietary and nutritional
preparations; dietary meal replacements for medical use;
dietary food supplements; weight loss preparations; powdered
nutritional supplements; fitness and endurance supplements;
all the aforesaid containing ketone esters or
hydroxybutyrates. Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks; recovery drinks; fruit beverages;
isotonic beverages; nutritionally fortified non-alcoholic
beverages; vitamin fortified non-alcoholic beverages;
waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
(1) Non-alcoholic drinks, namely, energy shots and non-alcoholic carbonated drinks; energy drinks; sports drinks; sports drinks for enhancing and increasing athletic performance; sports drinks for promoting faster muscle recovery after exercise; fruit beverages; isotonic beverages; non-alcoholic water-based and fruit-based beverages fortified with vitamins, minerals, nutrients, amino acids and herbs; vitamin fortified non-alcoholic water-based and fruit-based beverages; drinking waters; syrups for beverages; powders, concentrates and non-alcoholic preparations used in the preparation of soft drinks
(1) Non-alcoholic drinks, namely, energy shots and non-alcoholic carbonated drinks; energy drinks; sports drinks; sports drinks for enhancing and increasing athletic performance; sports drinks for promoting faster muscle recovery after exercise; fruit beverages; isotonic beverages; non-alcoholic water-based and fruit-based beverages fortified with vitamins, minerals, nutrients, amino acids and herbs; vitamin fortified non-alcoholic water-based and fruit-based beverages; drinking waters; syrups for beverages; powders, concentrates and non-alcoholic preparations used in the preparation of soft drinks
(1) Non-alcoholic drinks, namely, energy shots and non-alcoholic carbonated drinks, energy drinks, sports drinks, sports drinks for enhancing and increasing athletic performance, sports drinks for promoting faster muscle recovery after exercise, fruit beverages, isotonic beverages, non-alcoholic water-based and fruit-based beverages fortified with vitamins, minerals, nutrients, amino acids and herbs, vitamin fortified non-alcoholic water-based and fruit-based beverages, drinking waters, syrups for beverages, powders, concentrates and non-alcoholic preparations used in the preparation of soft drinks, all the aforesaid drinks preparations containing ketone esters or hydroxybutyrates
(1) Non-alcoholic drinks, namely, energy shots and non-alcoholic carbonated drinks, energy drinks, sports drinks, performance drinks, recovery drinks, fruit beverages, isotonic beverages, non-alcoholic water-based and fruit based beverages fortified with vitamins, minerals, nutrients, amino acids and herbs, vitamin fortified non-alcoholic beverages, drinking waters, syrups, powders, concentrates and non-alcoholic preparations used in the preparation of soft drinks, all the aforesaid drinks and preparations containing ketone esters or hydroxybutyrates
GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (USA)
Inventeur(s)
Clarke, Kieran
Veech, Richard Lewis
Abrégé
A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.
A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
A61Q 19/00 - Préparations pour les soins de la peau
A61Q 19/08 - Préparations contre le vieillissement
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages; medicinal drinks; health drinks; dietary
supplement drinks and drink mixes; preparations for making
medicated beverages; herbal beverages for medicinal use;
vitamin drinks; tonics; dietary and nutritional supplements,
dietary and nutritional preparations; dietary meal
replacements; dietary food supplements; weight loss
preparations; powdered nutritional supplements; fitness and
endurance supplements; all the aforesaid containing ketone
esters or hydroxybutyrates. Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks (terms too vague in the opinion of the
International Bureau - Rule 13 (2) (b) of the Regulations);
recovery drinks (terms too vague in the opinion of the
International Bureau - Rule 13 (2) (b) of the Regulations);
fruit beverages; isotonic beverages; nutritionally fortified
non-alcoholic beverages; vitamin fortified non-alcoholic
beverages; waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks (term considered too vague by the
International Bureau - rule 13 (2) (b) of the Regulations);
recovery drinks (term considered too vague by the
International Bureau - rule 13 (2) (b) of the Regulations);
fruit beverages; isotonic beverages; nutritionally fortified
non-alcoholic beverages; vitamin fortified non-alcoholic
beverages; waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages; medicinal drinks; health drinks; dietary
supplement drinks and drink mixes; preparations for making
medicated beverages; herbal beverages for medicinal use;
vitamin drinks; tonics; dietary and nutritional supplements,
dietary and nutritional preparations; dietary meal
replacements; dietary food supplements; weight loss
preparations; powdered nutritional supplements; fitness and
endurance supplements; all the aforesaid containing ketone
esters or hydroxybutyrates. Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks (the terms are too vague in the opinion
of the International Bureau for the purposes of
classification); recovery drinks (the terms are too vague in
the opinion of the International Bureau for the purposes of
classification); fruit beverages; isotonic beverages;
nutritionally fortified non-alcoholic beverages; vitamin
fortified non-alcoholic beverages; waters; syrups, powders,
concentrates and other non-alcoholic preparations for making
beverages; all the aforesaid drinks and preparations
containing ketone esters or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
(1) Dietetic beverages for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary supplement drinks and drink mixes for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; preparations for making beverages for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietetic beverages for promoting weight loss, maintenance of healthy joints, and anti-ageing purposes; vitamin drinks; tonics for boosting energy, to increase athletic endurance, for nutrition replacement, and for general health and well-being; dietary and nutritional supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, dietary and nutritional preparations for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary meal replacements namely nutritional supplement meal replacement beverages for boosting energy, vitamin preparations in the form of meal replacement drinks and powders; dietary food supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; weight loss preparations in the nature of weight loss powders and gels; powdered nutritional supplements namely protein powders for meal replacement for use as a dietary supplement; fitness and endurance supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, all the aforesaid containing ketone esters and hydroxybutyrates
(2) Non-alcoholic drinks namely energy drinks, protein enriched sports drinks, fruit drinks and juice drinks containing caloric substitutes for carbohydrates and used to maintain, promote and enhance fitness; energy drinks; sports drinks; performance drinks; recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified non-alcoholic beverages namely non-alcoholic beverages enhanced with vitamins, minerals, nutrients, amino acids and herbs, vitamin fortified non-alcoholic beverages, waters, syrups, powders, concentrates and other non-alcoholic preparations namely non-alcoholic fruit extracts for making beverages, all the aforesaid drinks and preparations containing ketone esters and hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages for medical use; medicinal drinks; health drinks in the nature of dietary supplement drink mixes for medical use; dietary supplement drinks and drink mixes; mixes for making medicated beverages; herbal beverages for medicinal use; dietary supplemental drinks in the nature of vitamin and mineral beverages; tonics for medical use, namely, medicinal drinks; dietary and nutritional supplements, dietary and nutritional vitamins; dietary meal replacements for medical use, namely, nutritional meal replacement bars, powders and gels for boosting energy; dietary food supplements; weight loss preparations in the nature of dietary food supplements; powdered nutritional supplements; fitness and endurance nutritional supplements; all the aforesaid containing ketone esters or hydroxybutyrates Non-alcoholic drinks, namely, energy shots, fruit drinks and soda water drinks; energy drinks; sports drinks; sports drinks, namely, performance drinks; sports drinks, namely, recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified water based or fruit based non-alcoholic beverages; vitamin fortified water based or fruit based non-alcoholic beverages; mineral, aerated and tonic waters; syrups for beverages, powders for making soft drinks, concentrates and other non-alcoholic preparations for making beverages in the nature of fruit drinks; all the aforesaid drinks and preparations containing ketone esters or hydroxybutyrates
An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.
A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine
A01N 37/02 - Acides carboxyliques saturés ou leurs thio-analoguesLeurs dérivés
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A23C 9/154 - Préparations à base de laitLait en poudre ou préparations à base de lait en poudre comportant des additifs contenant des substances épaississantes, des œufs ou des préparations à base de céréalesLait gélifié
A23L 27/00 - ÉpicesAgents aromatiques ou condimentsÉdulcorants artificielsSels de tableSubstituts diététiques du selLeur préparation ou leur traitement
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages adopted for medical use; medicinal drinks; health drinks in the nature of dietary supplement drink mixes; dietary supplement drinks and drink mixes; mixes for making medicated beverages; herbal beverages for medicinal use; dietary supplemental drinks in the nature of vitamin and mineral beverages; tonics for medical use; dietary and nutritional supplements, dietary and nutritional vitamins; dietary meal replacements, namely, nutritional meal replacement bars, powders and gels for boosting energy; dietary food supplements; weight loss preparations in the nature of dietary food supplements; powdered nutritional supplements; fitness and endurance nutritional supplements; all the aforesaid containing ketone esters or hydroxybutyrates Tonic water; non-alcoholic drinks, namely, energy shots, fruit drinks and soda drinks; energy drinks; sports drinks; sports drinks, namely, performance drinks; sports drinks, namely, recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified water based or fruit based non-alcoholic beverages; vitamin fortified water based or fruit based non-alcoholic beverages; mineral and aerated waters; syrups for beverages, powders for making soft drinks, concentrates and other non-alcoholic preparations for making beverages in the nature of fruit drinks; all the aforesaid drinks and preparations containing ketone esters or hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages adopted for medical use; tonics for medical use, namely, medicinal drinks; health drinks in the nature of dietary supplement drink mixes; dietary supplement drinks and drink mixes; mixes for making medicated beverages; herbal beverages for medicinal use; dietary supplemental drinks in the nature of vitamin and mineral beverages; dietary and nutritional supplements, dietary and nutritional vitamins; dietary meal replacements, namely, nutritional meal replacement bars, powders and gels for boosting energy; dietary food supplements; weight loss preparations in the nature of dietary food supplements; powdered nutritional supplements; fitness and endurance nutritional supplements; all the aforesaid containing ketone esters or hydroxybutyrates Tonic water; non-alcoholic drinks, namely, energy shots, fruit drinks and soda water drinks; energy drinks; sports drinks; sports drinks, namely, performance drinks; sports drinks, namely, recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified water based or fruit based non-alcoholic beverages; vitamin fortified water based or fruit based non-alcoholic beverages; mineral and aerated waters; syrups for beverages, powders for making soft drinks, concentrates and other non-alcoholic preparations for making beverages in the nature of fruit drinks; all the aforesaid drinks and preparations containing ketone esters or hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages for medical use; medicinal drinks; health drinks in the nature of dietary supplement drink mixes for medical use; dietary supplement drinks and drink mixes; mixes for making medicated beverages; herbal beverages for medicinal use; dietary supplemental drinks in the nature of vitamin and mineral beverages; tonics for medical use, namely, medicinal drinks; dietary and nutritional supplements, dietary and nutritional vitamins; dietary meal replacements for medical use, namely, nutritional meal replacement bars, powders and gels for boosting energy; dietary food supplements; weight loss preparations in the nature of dietary food supplements; powdered nutritional supplements; fitness and endurance nutritional supplements; all the aforesaid containing ketone esters or hydroxybutyrates Non-alcoholic drinks, namely, energy shots, fruit drinks and soda water drinks; energy drinks; sports drinks; sports drinks, namely, performance drinks; sports drinks, namely, recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified water based or fruit based non-alcoholic beverages; vitamin fortified water based or fruit based non-alcoholic beverages; mineral, aerated and tonic waters; syrups for beverages, powders for making soft drinks, concentrates and other non-alcoholic preparations for making beverages in the nature of fruit drinks; all the aforesaid drinks and preparations containing ketone esters or hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages for medical use; medicinal drinks; health drinks in the nature of dietary supplement drink mixes; dietary supplement drinks and drink mixes; mixes for making medicated beverages; herbal beverages for medicinal use; dietary supplemental drinks in the nature of vitamin and mineral beverages; nutritional supplements in the nature of tonics for medical use; dietary and nutritional supplements, dietary and nutritional vitamins; dietary meal replacements, namely, nutritional meal replacement bars, powders and gels for boosting energy; dietary food supplements; weight loss preparations in the nature of dietary food supplements; powdered nutritional supplements; fitness and endurance nutritional supplements; all the aforesaid containing ketone esters or hydroxybutyrates Non-alcoholic drinks, namely, energy shots, fruit drinks and soft drinks in the nature of soda; energy drinks; sports drinks; sports drinks, namely, performance drinks; sports drinks, namely, recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified water based or fruit based non-alcoholic beverages; vitamin fortified water based or fruit based non-alcoholic beverages; mineral, aerated and tonic waters; syrups for beverages, powders for making soft drinks, concentrates and other non-alcoholic preparations for making beverages in the nature of fruit drinks; all the aforesaid drinks and preparations containing ketone esters or hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages; medicinal drinks; health drinks; dietary
supplement drinks and drink mixes; preparations for making
medicated beverages; herbal beverages for medicinal use;
vitamin drinks; tonics; dietary and nutritional supplements,
dietary and nutritional preparations; dietary meal
replacements; dietary food supplements; weight loss
preparations; powdered nutritional supplements; fitness and
endurance supplements; all the aforesaid containing ketone
esters or hydroxybutyrates. Non-alcoholic drinks; energy drinks; sports drinks;
performance drinks; recovery drinks; fruit beverages;
isotonic beverages; nutritionally fortified non-alcoholic
beverages; vitamin fortified non-alcoholic beverages;
waters; syrups, powders, concentrates and other
non-alcoholic preparations for making beverages; all the
aforesaid drinks and preparations containing ketone esters
or hydroxybutyrates.
The present invention provides a method of suppressing hunger by lowering plasma ghrelin levels comprising administration of a compound to a human or animal body, wherein the compound is selected from: (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer of (R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof. The invention also provides a method of administering such a compound in a dosage effective to reduce hunger in order that a cosmetically beneficial loss or maintenance of body weight occurs, wherein in the method, plasma ghrelin levels are lowered. The aforementioned compound is also provided for use in a method of treatment of the human or animal body wherein the compound is administered and hunger is suppressed by lowering of plasma ghrelin levels. The compound is particularly useful for subjects having conditions associated with overeating, such as overweight, obese, severely obese patients or diabetic patients.
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (USA)
Inventeur(s)
Veech, Richard Lewis
Clarke, Kieran
Abrégé
Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.
Non-alcoholic drinks, namely, carbonated and non-carbonated fruit-flavoured beverages; energy drinks; sports drinks, namely, energy drinks; performance drinks, namely, sports drinks and energy drinks; sports drinks, namely, recovery drinks; fruit beverages; isotonic beverages; nutritionally fortified non-alcoholic beverages, namely, sports drinks and energy drinks enhanced with ketones, vitamins, minerals and nutrients, not for medical purposes; waters, namely, still waters and aerated mineral waters; syrups, powders, concentrates and other non-alcoholic preparations, namely, non-alcoholic fruit extracts for making beverages; all the aforesaid drinks and preparations containing ketone esters or hydroxybutyrates, not for medical purposes
44.
3-hydroxybutyrate compounds for use in reducing liver fat
The present invention provides a compound for use in reducing liver fat in a subject, wherein the compound is selected from: (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer obtainable by polymerising (R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof. The compound is particularly useful in subjects suffering from a fatty liver. The compound can be used to treat non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH) or non-alcoholic fatty liver (NAFL).
The present invention provides a compound for use in preventing or treating overtraining in a subject, wherein the compound is selected from (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer obtainable by oligomerising(R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
Dietetic beverages; medicinal drinks; dietary supplement
drinks and drink mixes; preparations for making medicated
beverages; herbal beverages for medicinal use; vitamin
drinks; tonics; dietary and nutritional supplements, dietary
and nutritional preparations; dietary meal replacements;
dietary food supplements; weight loss preparations in the
nature of weight loss powders and gels; powdered nutritional
supplements; fitness and endurance supplements; all the
aforesaid containing ketone esters or hydroxybutyrates. Non-alcoholic drinks containing caloric substitutes for
carbohydrates and used to maintain, promote and enhance
health, wellness and fitness and to treat medical
conditions; non-medicated non-alcoholic-based substances for
the treatment of muscle fatigue, muscle conditions,
epilepsy, anxiety, dementia, cancer, cachexia and cell
damage and substances for improving cognitive function,
raising ketone blood levels in humans or animals, all the
aforementioned containing ketone esters or hydroxybutyrates;
non-alcoholic beverages, fruit beverages, isotonic
beverages, nutritionally fortified beverages, sports drinks,
vitamin fortified non-alcoholic beverages, all the aforesaid
containing ketone esters or hydroxybutyrates; syrups and
other non-alcoholic preparations for making beverages
containing ketone esters or hydroxybutyrates.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Non-medicated preparations containing caloric substitutes
for carbohydrates and used to maintain, promote and enhance
health, wellness and fitness and to improve health;
non-medicated substances for the improvement of muscle
fatigue, muscle conditions, epilepsy, anxiety, dementia,
cancer, cachexia and cell damage and non-medicated
substances for improving cognitive function and raising
ketone blood levels in humans or animals, all the
aforementioned containing ketone esters or hydroxybutyrates;
all the aforementioned being creams, lotions, ointments and
preparations for cosmetic and skincare purposes. Caloric substitutes for carbohydrates used to maintain,
promote and enhance health, wellness and fitness and to
treat medical conditions; substances for the treatment of
muscle fatigue, muscle conditions, epilepsy, anxiety,
dementia, cancer, cachexia and cell damage and substances
for improving cognitive function and raising ketone blood
levels in humans or animals, all the aforementioned
containing ketone esters or hydroxybutyrates. Meat, fish, poultry and game; meat extracts; preserved,
frozen, dried and cooked fruits and vegetables; jellies,
jams, compotes; eggs; milk and milk products; edible oils
and fats; all the aforementioned containing caloric
substitutes for carbohydrates and used to maintain, promote
and enhance health, wellness and fitness and to improve
health or containing substances for the improvement of
muscle fatigue, muscle conditions, epilepsy, anxiety,
dementia, cancer, cachexia and cell damage and substances
for improving cognitive function, raising ketone blood
levels in humans or animals, all the aforementioned
containing ketone esters or hydroxybutyrates and not for
medical purposes. Foodstuffs of plant origin and preparations made from them,
ices and non-alcoholic drinks having a coffee, tea or cocoa
base; cereal preparations; all the aforementioned containing
caloric substitutes for carbohydrates and used to maintain,
promote and enhance health, wellness and fitness and to
improve health; non-medicated cereal-based and grain-based
food for the improvement of muscle fatigue, muscle
conditions, epilepsy, anxiety, dementia, cancer, cachexia
and cell damage and substances for improving cognitive
function, raising ketone blood levels in humans or animals;
non-medicated beverages with coffee, cocoa, chocolate or tea
base for the improvement of muscle fatigue, muscle
conditions, epilepsy, anxiety, dementia, cancer, cachexia
and cell damage and substances for improving cognitive
function, raising ketone blood levels in humans or animals;
non-medicated flavourings for food or beverages for the
improvement of muscle fatigue, muscle conditions, epilepsy,
anxiety, dementia, cancer, cachexia and cell damage and
substances for improving cognitive function, raising ketone
blood levels in humans or animals; all the aforementioned
containing ketone esters or hydroxybutyrates and not for
medical purposes. Non-alcoholic drinks containing caloric substitutes for
carbohydrates and used to maintain, promote and enhance
health, wellness and fitness and to improve health;
non-medicated non-alcoholic-based drinks and non-medicated
non-alcoholic preparations for making beverages for the
improvement of muscle fatigue, muscle conditions, epilepsy,
anxiety, dementia, cancer, cachexia and cell damage and
substances for improving cognitive function, raising ketone
blood levels in humans or animals, all the aforementioned
containing ketone esters or hydroxybutyrates and not for
medical purposes. Education and training in the field of caloric substitutes
for carbohydrates, ketone esters and hyroxybutyrates and
substances used to maintain, promote and enhance health,
wellness and fitness and to treat medical conditions such as
muscle fatigue, muscle conditions, epilepsy, anxiety,
dementia, cancer, cachexia and cell damage. Research and development in the field of caloric substitutes
for carbohydrates, ketone esters and hyroxybutyrates and
substances used to maintain, promote and enhance health,
wellness and fitness and to treat medical conditions such as
muscle fatigue, muscle conditions, epilepsy, anxiety,
dementia, cancer, cachexia and cell damage.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
32 - Bières; boissons non alcoolisées
Produits et services
(1) Dietetic beverages for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; medicinal drinks; dietary supplement drinks and drink mixes for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; preparations for making medicated beverages for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; herbal tea-based beverages for medicinal use namely herbal supplements for promoting weight loss, maintenance of healthy joints, and anti-ageing purposes; vitamin drinks; tonics for medical use for boosting energy, to increase athletic endurance, for nutrition replacement, and for general health and well-being; dietary and nutritional supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, dietary and nutritional preparations for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary meal replacements namely nutritional supplement meal replacement beverages for boosting energy, vitamin preparations in the form of meal replacement drinks and powders; dietary food supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; weight loss preparations in the nature of weight loss powders and gels; powdered nutritional supplements namely protein powders for meal replacement for use as a dietary supplement; fitness and endurance supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being, all the aforesaid containing a ketone ester and beta-hydroxybutyrate; non-medicated non-alcoholic-based sports and energy drinks for the treatment of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans and animals, all the aforementioned containing a ketone ester and beta-hydroxybutyrate; nutritionally fortified beverages containing a ketone ester and beta-hydroxybutyrate for boosting energy, providing athletic support, nutrition replacement, and for general health and well-being
(2) Non-alcoholic drinks namely energy drinks, protein enriched sports drinks, fruit drinks and juice drinks containing caloric substitutes for carbohydrates and used to maintain, promote and enhance fitness; non-alcoholic fruit beverages, isotonic beverages, sports drinks, vitamin fortified non-alcoholic beverages, all the aforesaid containing a ketone ester and beta-hydroxybutyrate; syrups and other non-alcoholic preparations namely non-alcoholic fruit extracts for making beverages containing a ketone ester and betahydroxybutyrate
11622162(R)111, wherein said alcohol is a sugar. Typically, the invention also provides treatment of the conditions associated with cachexia, such as muscle wasting.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Tonics for boosting energy, to increase athletic endurance, for nutrition replacement, and for general health and well-being; dietary and nutritional supplements for boosting energy, providing athletic support and nutrition replacement and for general health and well-being, dietary and nutritional preparations for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary meal replacements namely nutritional supplement meal replacement beverages for boosting energy, to increase athletic endurance, for nutrition replacement, and for general health and well-being, vitamin preparations in the form of meal replacement drinks and powders for boosting energy, to increase athletic endurance, for nutrition replacement, and for general health and well-being; dietary supplement drinks and drink mixes for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; dietary food supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; weight loss preparations namely dietary supplements for promoting weight loss; medicinal drinks namely drinks for boosting energy, providing athletic support, for nutrition replacement and for general health and well-being; preparations for making medicated beverages for boosting energy, providing athletic support, nutrition replacement and for general health and well-being; powdered nutritional supplements namely protein powders for meal replacement for use as a dietary supplement for boosting energy, to increase athletic endurance, for nutrition replacement, and for general health and well-being; fitness and endurance supplements for boosting energy, providing athletic support, nutrition replacement and for general health and well-being
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Non-medicated preparations used to maintain, promote and enhance the appearance of health, wellness and fitness and to improve skin health, non-medicated substances for the improvement of cell damage and non-medicated substances for raising ketone levels on human and animal skin, all the aforementioned containing a ketone ester and beta-hydroxybutyrate, all the aforementioned being creams, lotions, ointments and preparations for cosmetic and skincare purposes
(2) Caloric substitutes for carbohydrates used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions; substances for the treatment of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function and raising ketone blood levels in humans and animals, all the aforementioned containing ketone esters and beta-hydroxybutyrate
(3) Meat, fish, poultry and game, meat extracts, preserved, frozen, dried and cooked fruits and vegetables, jellies, jams, compotes, eggs, milk and milk products, edible oils and fats, all the aforementioned containing caloric substitutes for carbohydrates and used to maintain, promote and enhance health, wellness and fitness and to improve health and containing substances for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans and animals, all the aforementioned containing ketone esters and beta-hydroxybutyrate and not for medical purposes
(4) Plant-based prepared meals and snacks for human consumption, ices and non-alcoholic drinks having a coffee, tea and cocoa base, ices and non-alcoholic drinks having a coffee, tea and cocoa base, all the aforementioned containing caloric substitutes for carbohydrates and used to maintain, promote and enhance health, wellness and fitness and to improve health, non-medicated cereal-based and grain-based food namely cereal bars, cereal-based snack food and toasted grain flour for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans and animals, non-medicated beverages with coffee, cocoa, chocolate and tea base for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans and animals, non-medicated flavourings for food and beverages for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans and animals, all the aforementioned containing ketone esters and beta-hydroxybutyrate and not for medical purposes
(5) Non-alcoholic drinks namely fruit drinks and vegetable juice drinks containing caloric substitutes for carbohydrates and used to maintain, promote and enhance health, wellness and fitness and to improve health; non-medicated non-alcoholic-based drinks namely fruit drinks and vegetable juice drinks and non-medicated non-alcoholic preparations for making beverages for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans and animals, all the aforementioned containing ketone esters and beta-hydroxybutyrate and not for medical purposes (1) Education and training in the field of caloric substitutes for carbohydrates, ketone esters and hydroxybutyrates and substances used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions such as muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage.
(2) Research and development in the field of caloric substitutes for carbohydrates, ketone esters and hydroxybutyrates and substances used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions such as muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Tonics, namely, nutritional supplements in the form of tonics, dietetic beverages adapted for medical use being synthetic tonics for general health and well-being, ketone-based dietary supplements in the form of tonics; dietary and nutritional supplements, dietary and nutritional preparations, namely, ketone-based dietary and nutritional preparations in the nature of supplements for medical purposes; dietary meal replacements, namely, nutritional supplement meal replacement bars for boosting energy, nutritional meal replacement bars adapted for medical use for individuals undergoing medical treatments, meal replacement snacks adapted for medical use, ketone-based dietary meal replacement in the form of bars, drinks, and powders, for boosting energy; dietary supplement drinks and drink mixes; dietary food supplements; weight loss preparations, namely, dietary and nutritional supplements used for weight loss, ketone-based dietary meal replacement in the form of bars, drinks, and powders, for weight loss purposes; medicinal drinks; preparations for making medicated beverages, namely, nutritionally fortified beverages for medical purposes, dietetic beverages adapted for medical use, syrups for making meal replacement beverages adapted for medical use, ketone-based preparations in the nature of dietary supplements for making beverages; powdered nutritional supplements; dietary and nutritional supplements for fitness and endurance sports
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Non-medicated preparations containing caloric substitutes for carbohydrates and used to maintain, promote and enhance health, wellness and fitness and to improve health; non-medicated substances for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and non-medicated substances for improving cognitive function and raising ketone blood levels in humans or animals, all the aforementioned containing ketone esters or hydroxybutyrates; all the aforementioned being creams, lotions, ointments and preparations for cosmetic and skincare purposes Caloric substitutes for carbohydrates in the nature of nutritional supplements used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions, namely, Alzheimer's disease, Parkinson's disease, depression, muscular conditions, treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power, maintaining and improving cognitive function, raising blood ketone levels in the human or animal body, diabetes or disorder of glucose metabolism, cachexia, neuro-degenerative conditions, muscular dystrophic states, increasing metabolic efficiency, reducing fatigue, reducing muscle damage or wasting, inflammatory diseases and radiation damage, as well as epilepsy, anxiety, dementia, cancer, and cell damage; substances in the nature of nutritional and dietary supplements for the treatment of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage for improving cognitive function and raising ketone blood levels in humans or animals; all the aforementioned containing ketone esters or hydroxybutyrates Meat, fish not being live, poultry and game; meat extracts; preserved, frozen, dried and cooked fruits and vegetables; jellies, jams, compotes; eggs; milk and milk products excluding ice cream, ice milk and frozen yogurt; edible oils and fats; all the aforementioned containing caloric substitutes for carbohydrates and used to maintain, promote and enhance health, wellness and fitness and to improve health or containing substances for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans or animals, all the aforementioned containing ketone esters or hydroxybutyrates and not for medical purposes Foodstuffs of plant origin and preparations made from them, namely, food preparations and snacks containing fruit, vegetables, herbs, nuts, honey and maple syrup; flavored ices and non-alcoholic drinks having a coffee, tea or cocoa base; cereal preparations, namely, cereal flour, cereal powder, cereal bars, processed cereals, breakfast cereals, processed cereal seeds, cereal-based snack foods; all the aforementioned containing caloric substitutes for carbohydrates and used to maintain, promote and enhance health, wellness and fitness and to improve health, but not being adapted specifically for medical use; non-medicated cereal-based and grain-based food in the nature of snack foods, bread, chips for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans or animals; non-medicated beverages with coffee, cocoa, chocolate or tea base for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans or animals; non-medicated flavourings for food or beverages being non-essential oils for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function, raising ketone blood levels in humans or animals; all the aforementioned containing ketone esters or hydroxybutyrates and not for medical purposes Non-alcoholic drinks in the nature of soft drinks, energy drinks, fruit drinks containing caloric substitutes for carbohydrates and used to maintain, promote and enhance health, wellness and fitness and to improve health; non-medicated non-alcoholic-based drinks in the nature of carbonated beverages, aerated and mineral water, fruit and vegetable juices and non-medicated non-alcoholic syrups for making beverages for the improvement of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage for improving cognitive function, raising ketone blood levels in humans or animals; all the aforementioned containing ketone esters or hydroxybutyrates and not for medical purposes Education services, namely, classes, seminars, workshops and training in the field of caloric substitutes for carbohydrates, ketone esters and hyroxybutyrates and substances used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions such as muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage Research and development in the field of caloric substitutes for carbohydrates, ketone esters and hyroxybutyrates and substances used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions such as muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage
The present invention provides a method of suppressing hunger by lowering plasma ghrelin levels comprising administration of a compound to a human or animal body, wherein the compound is selected from: (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer of (R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof. The invention also provides a method of administering such a compound in a dosage effective to reduce hunger in order that a cosmetically beneficial loss or maintenance of body weight occurs, wherein in the method, plasma ghrelin levels are lowered. The aforementioned compound is also provided for use in a method of treatment of the human or animal body wherein the compound is administered and hunger is suppressed by lowering of plasma ghrelin levels. The compound is particularly useful for subjects having conditions associated with overeating, such as overweight, obese, severely obese patients or diabetic patients.
The present invention provides a compound for use in reducing liver fat in a subject, wherein the compound is selected from: (i) (R)-3-hydroxybutyrate; (ii) an ester of (R)-3-hydroxybutyrate; and (iii) an oligomer obtainable by polymerising (R)-3-hydroxybutyrate moieties; or a pharmaceutically acceptable salt or solvate thereof. The compound is particularly useful in subjects suffering from a fatty liver. The compound can be used to treat non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH) or non-alcoholic fatty liver (NAFL).
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Caloric substitutes for carbohydrates used to maintain,
promote and enhance health, wellness and fitness and to
treat medical conditions; substances for the treatment of
muscle fatigue, muscle conditions, epilepsy, anxiety,
dementia, cancer, cachexia and cell damage and substances
for improving cognitive function and raising ketone blood
levels in humans or animals, all the aforementioned
containing ketone esters or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Caloric substitutes for carbohydrates used to maintain,
promote and enhance health, wellness and fitness and to
treat medical conditions; substances for the treatment of
muscle fatigue, muscle conditions, epilepsy, anxiety,
dementia, cancer, cachexia and cell damage and substances
for improving cognitive function and raising ketone blood
levels in humans or animals, all the aforementioned
containing ketone esters or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Caloric substitutes for carbohydrates used to maintain,
promote and enhance health, wellness and fitness and to
treat medical conditions; substances for the treatment of
muscle fatigue, muscle conditions, epilepsy, anxiety,
dementia, cancer, cachexia and cell damage and substances
for improving cognitive function and raising ketone blood
levels in humans or animals, all the aforementioned
containing ketone esters or hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Caloric substitutes for carbohydrates, namely nutritional supplements, used to maintain and promote general health and well-being and for the treatment of muscle fatigue, muscle pain, inflammatory muscle disease, muscle damage, muscle wasting, muscular dystrophy, epilepsy, anxiety, dementia, cancer, cachexia, cell damage, Alzheimer's disease, Parkinson's disease, depression, and for treating, preventing and aiding recovery from fatigue, improving muscle function efficiency and muscular power, maintaining and improving cognitive function, raising blood ketone levels in the human or animal body, diabetes and disorder of glucose metabolism, neuro-degenerative diseases and disorders, namely Alzheimer's disease, Parkinson's disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, muscular dystrophic states, increasing metabolic efficiency, reducing fatigue, inflammatory diseases and disorders, namely inflammatory bowel disease, inflammatory connective tissue diseases and disorders, and inflammatory muscle diseases and disorders and radiation damage, all the aforementioned containing ketone esters and/or hydroxybutyrates; dietary supplements for the treatment of muscle fatigue, muscle pain, inflammatory muscle diseases and disorders, muscle damage, muscle wasting, muscular dystrophy, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and dietary supplements for improving cognitive function and raising ketone blood levels in humans and in animals, all the aforementioned containing ketone esters and/or hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Caloric substitutes for carbohydrates, namely nutritional supplements, used to maintain and promote general health and well-being and for the treatment of muscle fatigue, muscle pain, inflammatory muscle disease, muscle damage, muscle wasting, muscular dystrophy, epilepsy, anxiety, dementia, cancer, cachexia, cell damage, Alzheimer's disease, Parkinson's disease, depression, and for treating, preventing and aiding recovery from fatigue, improving muscle function efficiency and muscular power, maintaining and improving cognitive function, raising blood ketone levels in the human or animal body, diabetes and disorder of glucose metabolism, neuro-degenerative diseases and disorders, namely Alzheimer's disease, Parkinson's disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, muscular dystrophic states, increasing metabolic efficiency, reducing fatigue, inflammatory diseases and disorders, namely inflammatory bowel disease, inflammatory connective tissue diseases and disorders, and inflammatory muscle diseases and disorders and radiation damage, all the aforementioned containing ketone esters and/or hydroxybutyrates; dietary supplements for the treatment of muscle fatigue, muscle pain, inflammatory muscle diseases and disorders, muscle damage, muscle wasting, muscular dystrophy, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and dietary supplements for improving cognitive function and raising ketone blood levels in humans and in animals, all the aforementioned containing ketone esters and/or hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Caloric substitutes for carbohydrates, namely nutritional supplements, used to maintain and promote general health and well-being and for the treatment of muscle fatigue, muscle pain, inflammatory muscle disease, muscle damage, muscle wasting, muscular dystrophy, epilepsy, anxiety, dementia, cancer, cachexia, cell damage, Alzheimer's disease, Parkinson's disease, depression, and for treating, preventing and aiding recovery from fatigue, improving muscle function efficiency and muscular power, maintaining and improving cognitive function, raising blood ketone levels in the human or animal body, diabetes and disorder of glucose metabolism, neuro-degenerative diseases and disorders, namely Alzheimer's disease, Parkinson's disease, cerebral palsy, brain injury, spinal cord injury, seizure disorders, muscular dystrophic states, increasing metabolic efficiency, reducing fatigue, inflammatory diseases and disorders, namely inflammatory bowel disease, inflammatory connective tissue diseases and disorders, and inflammatory muscle diseases and disorders and radiation damage, all the aforementioned containing ketone esters and/or hydroxybutyrates; dietary supplements for the treatment of muscle fatigue, muscle pain, inflammatory muscle diseases and disorders, muscle damage, muscle wasting, muscular dystrophy, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and dietary supplements for improving cognitive function and raising ketone blood levels in humans and in animals, all the aforementioned containing ketone esters and/or hydroxybutyrates
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Caloric substitutes for carbohydrates in the nature of nutritional supplements used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions, namely, Alzheimer's disease, Parkinson's disease, depression, muscular conditions, treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power, maintaining and improving cognitive function, raising blood ketone levels in the human or animal body, diabetes or disorder of glucose metabolism, cachexia, neuro-degenerative conditions, muscular dystrophic states, increasing metabolic efficiency, reducing fatigue, reducing muscle damage or wasting, inflammatory diseases and radiation damage, as well as epilepsy, anxiety, dementia, cancer, and cell damage; substances in the nature of nutritional and dietary supplements for the treatment of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function and raising ketone blood levels in humans or animals; all the aforementioned containing ketone esters or hydroxybutyrates as an integrated component ingredient
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Caloric substitutes for carbohydrates in the nature of nutritional supplements used to maintain, promote and enhance health, wellness and fitness and to treat medical conditions, namely, alzheimer's disease, parkinson's disease, depression, muscular conditions, treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power, maintaining and improving cognitive function, raising blood ketone levels in the human or animal body, diabetes or disorder of glucose metabolism, cachexia, neuro-degenerative conditions, muscular dystrophic states, increasing metabolic efficiency, reducing fatigue, reducing muscle damage or wasting, inflammatory diseases and radiation damage, as well as epilepsy, anxiety, dementia, cancer, and cell damage; substances in the nature of nutritional and dietary supplements for the treatment of muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia and cell damage and substances for improving cognitive function and raising ketone blood levels in humans or animals; all the aforementioned containing ketone esters or hydroxybutyrates as an integrated component ingredient
65.
Ketone bodies to protect tissues from damage by ionizing radiation
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (USA)
Inventeur(s)
Veech, Richard Lewis
Clarke, Kieran
Abrégé
Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
31 - Produits agricoles; animaux vivants
32 - Bières; boissons non alcoolisées
33 - Boissons alcoolisées à l'exception des bières
Produits et services
(1) Creams, lotions and skin care preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, creams, lotions and skin care preparations containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; cosmetics, namely, creams, lotions and skin care preparations for use in combination with ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; essential oils for food flavouring
(2) Nutritional additives, namely, food and beverage additives for use in pharmaceutical and veterinary preparations, namely ketone esters for providing calories; dietary supplements, namely ketone esters for alleviating hunger and fatigue; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; dietary supplements for controlling cholesterol; dietary supplements for general health and wellbeing; pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease, including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets and ointments; esters, namely, ketone body esters for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; ketone body esters, hydroxybutyrates, acetoacetate, and mid-chain triglycerides (MCT) for raising blood ketone levels in the human or animal body; ketone body esters, hydroxybutyrates, and mid-chain triglycerides (MCT) for administration pre-surgery and post-surgery and for use in intensive care treatment for treating medical conditions, namely vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, Alzheimer's disease, Parkinson's disease, depression, anxiety, ADHD (attention deficit hyperactivity disorder), sleep disorders, head injury, stroke, spinal cord injury, heart attack, heart failure; ketone body esters, hydroxybutyrates, and mid-chain triglycerides (MCT) for muscular conditions, namely treating, preventing and aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining and improving cognitive function, and for raising blood ketone levels in the human or animal body; creams, lotions and skin care preparations for pharmaceutical or veterinary purposes in particular for use on the skin namely creams, lotions and skin care preparations containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides for cleaning, moisturising, healing, smoothing of the skin and for anti-aging, anti-wrinkling, sun damage, sun burn, burns; creams, lotions and skin care preparations for pharmaceutical and veterinary purposes in particular for use on the skin namely creams, lotions and skin care preparations for use in combination with ketone body esters in particular hydroxybutyrates and midchain triglycerides for cleaning, moisturising, healing, smoothing of the skin and for anti-aging, anti-wrinkling, sun damage, sun burn, burns; nutritional additives adapted for oral, topical, sublingual and intravenous administration to the human and animal body, namely, food and beverage additives for use in pharmaceutical and veterinary preparations, namely ketone esters for providing calories; pharmaceutical and veterinary preparations adapted for oral, topical, sublingual and intravenous administration to the human and animal body for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; esters, namely, ketone body esters adapted for oral, topical, sublingual and intravenous administration to the human and animal body for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; hydroxybutyrates adapted for oral, topical, sublingual and intravenous administration to the human and animal body for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; mid-chain triglycerides (MCT) adapted for oral, topical, sublingual and intravenous administration to the human and animal body for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease, cancer, cell damage; ices for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in humans and animals; grain-based snack foods for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in humans and animals; energy drinks, fruit drinks and fruit juices for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body
(3) Foodstuffs of animal origin, namely meat, eggs, cheese and yogurt, milk products, comestible vegetable products, namely canned fruits and vegetables, bottled fruits and vegetables, preserved fruits and vegetables, and frozen fruits and vegetables, candied nuts, flavoured nuts, roasted nuts, cashew nut butter, honey butter; meat, eggs, cheese, yogurt, milk, canned fruits and vegetables, bottled fruits and vegetables, preserved fruits and vegetables, and frozen fruits and vegetables, candied nuts, flavoured nuts, roasted nuts, and cashew nut butter; meat, eggs, cheese, yogurt, milk, canned fruits and vegetables, bottled fruits and vegetables, preserved fruits and vegetables, and frozen fruits and vegetables, candied nuts, flavoured nuts, roasted nuts, cashew nut butter and honey for use in combination with ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; grain-based beverages, namely oat milk, rice milk, barley milk, wheat protein drinks; grain-based beverages, namely oat milk, rice milk, barley milk, wheat protein drinks for use in combination with ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; grainbased beverages, namely oat milk, rice milk, barley milk, wheat protein drinks for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in humans and animals; vegetable purees
(4) Foodstuffs of plant origin and preparations made from them, namely dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup and honey, ices; cereal preparations, namely processed cereals, cereal flour, cereal powders, cereal bars, breakfast cereals, cereal-based snack food, cereals, grainbased chips, toasted grain flour and grain-based snack foods; vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, honey, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup, processed cereal products, namely breakfast cereals, cereal bars, cereal-based snack foods containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, honey, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup, processed cereals, cereal flour, cereal powders, cereal bars, breakfast cereals, cereal-based snack food, cereals, grain-based chips, toasted grain flour and grain-based snack foods for use in combination with ketone body esters in particular hyroxybutyrates and mid-chain triglycerides; beverage flavourings; food flavourings; foodstuffs of plant origin, namely vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup and honey; vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup and honey, and ices containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; cereal preparations, namely processed cereals, cereal flour, cereal powders, cereal bars, breakfast cereals, cereal-based snack food, cereals, grain-based chips, and toasted grain flour; honey containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides
(5) Non-alcoholic drinks and gels other than milk products and those having a coffee or tea base, namely energy drinks; beers; fruit drinks and fruit juices; syrups, concentrates and powders for making soft drinks other than milk products and those having a coffee or tea base; energy drinks, fruit drinks and fruit juices containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; energy drinks, fruit drinks and fruit juices for use in combination with ketone body esters in particular hydroxybutyrates and midchain triglycerides; ices, drinks and gels namely iced energy drinks, energy drinks and energy gels containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides
(6) Alcoholic beverages (except beers) namely vodka, gin, sherry, port, whisky, aperitifs and cognac; alcoholic energy drinks; alcoholic energy drinks, fruit drinks, fruit juices containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; alcoholic energy drinks, fruit drinks, fruit juices used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
33 - Boissons alcoolisées à l'exception des bières
Produits et services
Creams, non-medicated lotions or other non-medicated preparations in the nature of ointments for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, any creams, lotions or other preparations in the nature of cosmetic preparations containing or used in combination with ketone body esters in particular hydroxybutyrates and mid-chain triglycerides Nutritional Additives For Use In Pharmaceutical Or Veterinary Preparations, In The Nature Of Medicated And Non-Medicated Additives For Animal Feed For Use As Nutritional Supplements And Nutritional Additives For Medical Purposes; Dietetic Substances For Use In Pharmaceutical Or Veterinary Preparations In The Nature Of Dietetic Foods Adapted For Veterinary Use And For Pharmaceutical Use; Pharmaceutical Preparations In The Form Of Foods, Ices, Drinks, Infusions, Syrups, Toffees, Chewing Gums Tablets Or Ointments, Namely, Dietetic Food And Beverages For Infants And Invalids; Esters Including Ketone Body Esters For Use As Additives In Pharmaceutical And Veterinary Preparations Namely, Medicated Food Supplements For Animals And Humans; Nutritional Supplements Containing Components For Raising Blood Ketone Levels In The Human Or Animal Body; Nutritional Supplements For Treating Medical Conditions Including Vascular Conditions, Weight Loss, Diabetes, Heart Failure, Sickle Cell Anaemia, Trauma, Administration Pre-Surgery Or Post-Surgery, Use In Intensive Care Treatment And Conditions Of The Brain Including Alzheimer's Disease, Parkinson's Disease, Depression; Nutritional Supplements For Muscular Conditions Including Treating, Preventing Or Aiding Recovery From Fatigue, Improving Muscle Function Efficiency And Muscular Power And In Maintaining Or Improving Cognitive Function, Or For Raising Blood Ketone Levels In The Human Or Animal Body; Medicated Creams, Lotions And Other Preparations In The Nature Of Ointments For Pharmaceutical Or Veterinary Purposes For The Treatment Of Muscle Fatigue, Muscle Conditions, Epilepsy, Anxiety, Dementia, Cancer, Cachexia And Cell Damage And For Improving Cognitive Function And For Raising Ketone Blood Levels In Humans And Animals Featuring Ketone Body Esters In Particular Hydroxybutyrates And/Or Mid-Chain Triglycerides; Additives Or Preparations For Oral, Topical, Sublingual Or Intravenous Administration To The Human Or Animal Body, Namely, Dietary And Nutritional Supplements And Medicated Additives For Use As Additives To Food For Human Consumption Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Fruit, namely, fruit cake, fruit pies, pastries with fruit, fruit sauces and frozen fruit confectionery; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Vegetables, namely, vegetable pies, vegetable-flavoured crackers, pastries consisting of vegetables; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Herbs, namely, processed culinary herbs, processed herbs, preserved herbs, dried herbs, marinades containing herbs and herb-flavoured crackers; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Nuts, namely, chocolate-covered nuts, yogurt-covered nuts, chocolate spreads containing nuts; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Honey, namely, honey buns, honeycomb toffee, honey spreads, namely, honey infused with vitamins; maple Syrup; Processed Cereals; Cereal Flour; Processed cereal, namely, oatmeal cereal powder, rice cereal powder and multi-grain cereal powder; Cereal Bars; Breakfast Cereals; Cereal based snack food; Processed Grains, Grain-Based Beverages, Grain-Based Chips, Toasted Grain Flour And Grain-Based Snack Foods; Ices, namely, Ice, Italian Ice, Water Ice; Cereal Preparations, In The Nature Of Processed Cereals; Foodstuffs And Preparations Containing Ketone Body Esters In Particular Hydroxybutyrates And/Or Mid-Chain Triglycerides, In The Nature Of Rice, Tapioca And Sago, Bread, Pastries And Confectionery Made Of Sugar Or Sugar Substitutes; Flavourings For Foodstuffs, For Cereal Preparations, For Ices Or For Drinks, In The Nature Of Food Flavourings Being Non-Essential Oils; Ices Containing Components For Preventing, Treating Or Aiding Recovery From Fatigue, For Increasing Muscle Function Efficiency Or For Raising Blood Ketone Levels In The Human Or Animal Body, In The Nature Of Ices; Processed Cereals, Cereal Flour, Cereal Powders, Cereal Bars, Breakfast Cereals, Processed Cereal Seeds, Cereal Snacks, Processed Grains, Grain-Based Beverages, Grain-Based Chips, Toasted Grain Flour And Grain-Based Snack Foods, Containing Ketone Body Esters In Particular Hydroxybutyrates And Mid-Chain Triglycerides; Cereal Preparations Containing Components For Preventing, Treating Or Aiding Recovery From Fatigue, For Increasing Muscle Function Efficiency Or For Raising Blood Ketone Levels In The Human Or Animal Body, In The Nature Of Processed Cereals Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Fruit, namely, fruit cake, fruit pies, pastries with fruit, fruit sauces and frozen fruit confectionery; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Vegetables, namely, vegetable pies, vegetable-flavoured crackers, pastries consisting of vegetables; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Herbs, namely, processed culinary herbs, processed herbs, preserved herbs, dried herbs, marinades containing herbs and herb-flavoured crackers; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Nuts, namely, chocolate-covered nuts, yogurt-covered nuts, chocolate spreads containing nuts; Foodstuffs of Plant Origin and Preparations Made from Them, In the Nature of Food and Snacks Containing Honey, namely, honey buns, honeycomb toffee, honey spreads, namely, honey infused with vitamins; maple Syrup; Processed Cereals; Cereal Flour; Processed cereal, namely, oatmeal cereal powder, rice cereal powder and multi-grain cereal powder; Cereal Bars; Breakfast Cereals; Cereal based snack food; Processed Grains, Grain-Based Beverages, Grain-Based Chips, Toasted Grain Flour And Grain-Based Snack Foods; Ices, namely, Ice, Italian Ice, Water Ice; Cereal Preparations, In The Nature Of Processed Cereals; Foodstuffs And Preparations Containing Ketone Body Esters In Particular Hydroxybutyrates And/Or Mid-Chain Triglycerides, In The Nature Of Rice, Tapioca And Sago, Bread, Pastries And Confectionery Made Of Sugar Or Sugar Substitutes; Flavourings For Foodstuffs, For Cereal Preparations, For Ices Or For Drinks, In The Nature Of Food Flavourings Being Non-Essential Oils; Ices Containing Components For Preventing, Treating Or Aiding Recovery From Fatigue, For Increasing Muscle Function Efficiency Or For Raising Blood Ketone Levels In The Human Or Animal Body, In The Nature Of Ices; Processed Cereals, Cereal Flour, Cereal Powders, Cereal Bars, Breakfast Cereals, Processed Cereal Seeds, Cereal Snacks, Processed Grains, Grain-Based Beverages, Grain-Based Chips, Toasted Grain Flour And Grain-Based Snack Foods, Containing Ketone Body Esters In Particular Hydroxybutyrates And Mid-Chain Triglycerides; Cereal Preparations Containing Components For Preventing, Treating Or Aiding Recovery From Fatigue, For Increasing Muscle Function Efficiency Or For Raising Blood Ketone Levels In The Human Or Animal Body, In The Nature Of Processed Cereals Non-Alcoholic Drinks And Gels In The Nature Of Energy Shots And Fruit Beverages Other Than Milk Products And Those Having A Coffee, Tea Or Cocoa Base; Beers, Namely, Alcoholic Beer And Non-Alcoholic Beer; Fruit Drinks And Fruit Juices; Syrups And Other Preparations For Making Non-Alcoholic Drinks Other Than Milk Products And Those Having A Coffee, Tea Or Cocoa Base Namely, Fruit Drinks, Beer And Ale; Non-Alcoholic Drinks, Gels Or Beverages Containing Ketone Body Esters In Particular Hydroxybutyrates And/Or Mid-Chain Triglycerides And Energy Drinks And Gels, In The Nature Of Energy Drinks, Fruit Drinks And Soda Drinks; Non-Alcoholic Drinks, Gels Or Beverages Containing Components For Preventing, Treating Or Aiding Recovery From Fatigue, For Increasing Muscle Function Efficiency Or For Raising Blood Ketone Levels In The Human Or Animal Body In The Nature Of Energy Drinks, Fruit Drinks And Soda Drinks; Ices, Drinks And Gels, Namely, Fruit Beverages; Energy Ices In The Nature Of Iced Fruit Beverages, Energy Drinks And Energy Drinks In The Form Of Gels Containing Ketone Body Esters In Particular Hydroxybutyrates And/Or Mid-Chain Triglycerides Alcoholic beverages, except beers; alcoholic energy beverages; alcoholic beverages, except beers and alcoholic energy beverages containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
31 - Produits agricoles; animaux vivants
32 - Bières; boissons non alcoolisées
33 - Boissons alcoolisées à l'exception des bières
Produits et services
(1) Creams, lotions and skin care preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, creams, lotions and skin care preparations containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; cosmetics, namely, creams, lotions and skin care preparations for use in combination with ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; essential oils for food flavouring
(2) Nutritional additives, namely, food and beverage additives for use in pharmaceutical and veterinary preparations, namely ketone esters for providing calories; dietary supplements, namely ketone esters for alleviating hunger and fatigue; dietetic substances consisting of vitamins, minerals, amino acids and trace elements; dietary supplements for controlling cholesterol; dietary supplements for general health and wellbeing; pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease, including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets and ointments; esters, namely, ketone body esters for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; ketone body esters, hydroxybutyrates, acetoacetate, and mid-chain triglycerides (MCT) for raising blood ketone levels in the human or animal body; ketone body esters, hydroxybutyrates, and mid-chain triglycerides (MCT) for administration pre-surgery and post-surgery and for use in intensive care treatment for treating medical conditions, namely vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, Alzheimer's disease, Parkinson's disease, depression, anxiety, ADHD (attention deficit hyperactivity disorder), sleep disorders, head injury, stroke, spinal cord injury, heart attack, heart failure; ketone body esters, hydroxybutyrates, and mid-chain triglycerides (MCT) for muscular conditions, namely treating, preventing and aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining and improving cognitive function, and for raising blood ketone levels in the human or animal body; creams, lotions and skin care preparations for pharmaceutical or veterinary purposes in particular for use on the skin namely creams, lotions and skin care preparations containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides for cleaning, moisturising, healing, smoothing of the skin and for anti-aging, anti-wrinkling, sun damage, sun burn, burns; creams, lotions and skin care preparations for pharmaceutical and veterinary purposes in particular for use on the skin namely creams, lotions and skin care preparations for use in combination with ketone body esters in particular hydroxybutyrates and midchain triglycerides for cleaning, moisturising, healing, smoothing of the skin and for anti-aging, anti-wrinkling, sun damage, sun burn, burns; nutritional additives adapted for oral, topical, sublingual and intravenous administration to the human and animal body, namely, food and beverage additives for use in pharmaceutical and veterinary preparations, namely ketone esters for providing calories; pharmaceutical and veterinary preparations adapted for oral, topical, sublingual and intravenous administration to the human and animal body for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; esters, namely, ketone body esters adapted for oral, topical, sublingual and intravenous administration to the human and animal body for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; hydroxybutyrates adapted for oral, topical, sublingual and intravenous administration to the human and animal body for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease; mid-chain triglycerides (MCT) adapted for oral, topical, sublingual and intravenous administration to the human and animal body for use as additives in pharmaceutical and veterinary preparations for the treatment of Alzheimer's disease, Parkinson's disease, depression, fatigue, radiation damage, cognitive function, diabetes, cachexia, anxiety, epilepsy, dementia, cancer, cell damage, ALS, arthritis, glycogen depletion, muscle wasting, muscular dystrophy, coeliac disease, inflammatory bowel disease, Huntington's disease, cancer, cell damage; ices for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in humans and animals; grain-based snack foods for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in humans and animals; energy drinks, fruit drinks and fruit juices for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body
(3) Foodstuffs of animal origin, namely meat, eggs, cheese and yogurt, milk products, comestible vegetable products, namely canned fruits and vegetables, bottled fruits and vegetables, preserved fruits and vegetables, and frozen fruits and vegetables, candied nuts, flavoured nuts, roasted nuts, cashew nut butter, honey butter; meat, eggs, cheese, yogurt, milk, canned fruits and vegetables, bottled fruits and vegetables, preserved fruits and vegetables, and frozen fruits and vegetables, candied nuts, flavoured nuts, roasted nuts, and cashew nut butter; meat, eggs, cheese, yogurt, milk, canned fruits and vegetables, bottled fruits and vegetables, preserved fruits and vegetables, and frozen fruits and vegetables, candied nuts, flavoured nuts, roasted nuts, cashew nut butter and honey for use in combination with ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; grain-based beverages, namely oat milk, rice milk, barley milk, wheat protein drinks; grain-based beverages, namely oat milk, rice milk, barley milk, wheat protein drinks for use in combination with ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; grainbased beverages, namely oat milk, rice milk, barley milk, wheat protein drinks for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in humans and animals; vegetable purees
(4) Foodstuffs of plant origin and preparations made from them, namely dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup and honey, ices; cereal preparations, namely processed cereals, cereal flour, cereal powders, cereal bars, breakfast cereals, cereal-based snack food, cereals, grainbased chips, toasted grain flour and grain-based snack foods; vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, honey, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup, processed cereal products, namely breakfast cereals, cereal bars, cereal-based snack foods containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, honey, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup, processed cereals, cereal flour, cereal powders, cereal bars, breakfast cereals, cereal-based snack food, cereals, grain-based chips, toasted grain flour and grain-based snack foods for use in combination with ketone body esters in particular hyroxybutyrates and mid-chain triglycerides; beverage flavourings; food flavourings; foodstuffs of plant origin, namely vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup and honey; vegetable pies, vegetable burger sandwiches, vegetable concentrates used for seasoning, flavourings made from vegetables, flavourings made from fruits, dried and fresh herbs for food purposes, dried and fresh edible fungi, maple syrup and honey, and ices containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; cereal preparations, namely processed cereals, cereal flour, cereal powders, cereal bars, breakfast cereals, cereal-based snack food, cereals, grain-based chips, and toasted grain flour; honey containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides
(5) Non-alcoholic drinks and gels other than milk products and those having a coffee or tea base, namely energy drinks; beers; fruit drinks and fruit juices; syrups, concentrates and powders for making soft drinks other than milk products and those having a coffee or tea base; energy drinks, fruit drinks and fruit juices containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; energy drinks, fruit drinks and fruit juices for use in combination with ketone body esters in particular hydroxybutyrates and midchain triglycerides; ices, drinks and gels namely iced energy drinks, energy drinks and energy gels containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides
(6) Alcoholic beverages (except beers) namely vodka, gin, sherry, port, whisky, aperitifs and cognac; alcoholic energy drinks; alcoholic energy drinks, fruit drinks, fruit juices containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; alcoholic energy drinks, fruit drinks, fruit juices used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
33 - Boissons alcoolisées à l'exception des bières
Produits et services
Non-medicated skin care creams, lotions and preparations for cosmetic purposes; cosmetics; cosmetics, namely, skin care creams, lotions and preparations containing ketone body esters in the nature of hydroxybutyrates and mid-chain triglycerides Nutritional additives in the nature of dietary supplements for use in pharmaceutical or veterinary preparations; dietetic substances for medical purposes, namely, dietary supplements for pharmaceutical and veterinary purposes; pharmaceutical and veterinary preparations in the nature of medicinal drinks, dietetic infusions for medical use, syrups for medical treatment purposes, chewing gum for medical purposes, medicinal preparations in the form of tablets, and ointments for medical use; ketone body esters for medical purposes for use as additives in pharmaceutical and veterinary preparations; ketones, namely, hydroxybutyrates for use as additives for medical purposes in pharmaceutical and veterinary preparations for the treatment of conditions, namely, muscle fatigue, muscle conditions, epilepsy, anxiety, dementia, cancer, cachexia, cell damage, Alzheimer's disease, depression, diabetes, weight loss, Parkinson's disease, heart failure, sickle cell anemia, trauma and neuro-degenerative conditions and for improving cognitive function and raising blood ketone levels in the human or animal body; mid-chain triglycerides (MCT) for medical purposes for use as additives in pharmaceutical and veterinary preparations; additives, namely, neutraceuticals containing ketone esters for medical purposes for use in pharmaceutical preparations for raising blood ketone levels in humans and animals; additives, namely, neutraceuticals for medical purposes for use in pharmaceutical preparations for treating medical vascular conditions, weight loss, diabetes, heart failure, sickle cell anemia, trauma, Alzheimer's disease, Parkinson's disease and depression; additives, namely, neutraceuticals for medical purposes for use in pharmaceutical preparations for the treatment of muscular conditions, preventing and aiding fatigue, muscle function efficiency, muscular power, improving cognitive function, and raising blood ketone levels in humans and animals; skin treatments, namely, creams, lotions and medicinal preparations featuring ketone esters comprised of hydroxybutyrates and mid-chain triglycerides for pharmaceutical or veterinary purposes; additives, namely, nutritional food and beverage additives for medical purposes for use in pharmaceutical preparations adapted for oral, topical, sublingual or intravenous administration to humans and animals Foodstuffs of animal origin, namely, chicken, beef, pork, all natural and processed lamb; comestible vegetable products, and comestible horticultural products, namely, processed vegetables and processed fruit; processed products, namely, processed vegetables and processed fruit; the above foodstuffs, vegetable or other products, namely, processed vegetables and processed fruit containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; foodstuffs of animal origin, namely, chicken, beef, pork, all natural and processed lamb; comestible vegetable products and any other comestible horticultural products, namely, processed vegetables and processed fruit containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides Foodstuffs of plant origin, namely, food preparations and snacks containing fruit, vegetables, herbs, nuts, honey and maple syrup; preparations made from cereals, namely, cereal flour, cereal powders, cereal bars, processed cereals, breakfast cereals, processed cereal seeds and cereal snacks; foodstuffs of plant origins, namely, food preparations and snacks containing fruit, vegetables, herbs, nuts, honey and maple syrup containing ketone body esters in the nature of hydroxybutyrates and mid-chain triglycerides; flavorings, other than essential oils, for foodstuffs, cereal preparations, edible ices and non-alcoholic drinks; foodstuffs of plant origin, namely, food preparations and snacks containing fruit, vegetables, herbs, nuts, honey and maple syrup containing ketone body esters in the nature of hydroxybutyrates and mid-chain triglycerides for preventing, treating fatigue, increasing muscle function efficiency and raising blood ketone levels in human and animal bodies; cereal preparations containing ketone body esters in the nature of hydroxybutyrates and mid-chain triglycerides for preventing, treating fatigue, increasing muscle function efficiency and raising blood ketone levels in humans and animals; flavored ices made of fruit or vegetables containing ketone body esters in particular hydroxybutyrates and mid-chain triglycerides; toffee Non-alcoholic beverages, namely, flavored drinks containing ketone body esters in the nature of hydroxybutyrates and mid-chain triglycerides; iced beverages and non-alcoholic drinks containing ketone body esters in the nature of hydroxybutyrates and mid-chain triglycerides for preventing, treating fatigue, increasing muscle function efficiency and raising blood ketone levels in humans and animals body; Non-alcoholic drinks and non-alcoholic drinks in gel form other than milk products and those having a coffee, tea or cocoa base, namely, energy shots, beer flavored beverages, carbonated beverages and beverages containing fruit juices; beers; fruit drinks and fruit juices; syrups for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; non-alcoholic drinks, non-alcoholic drinks in gel form or beverages namely, energy shots, beer flavored beverages, carbonated beverages and beverages containing fruit juices; the above beverages and preparations made containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides and energy drinks and non-alcoholic drinks in gel form; non-medicinal, non-alcoholic drinks or beverages, namely, energy shots, beer flavored beverages, carbonated beverages and beverages containing fruit juices, containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; flavored iced drinks, namely, fruit drinks, vegetable drinks and energy drinks, energy ice drinks made of fruit or vegetables; and energy drinks containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides Alcoholic beverages, except beers; alcoholic energy beverages; alcoholic beverages infused with ketone body esters in the nature of hydroxybutyrates and/or mid-chain triglycerides
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
33 - Boissons alcoolisées à l'exception des bières
Produits et services
Creams, lotions or other preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, any creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides. Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human or animal body; creams, lotions and other preparations for pharmaceutical or veterinary purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Fooodstuffs of animal origin, milk products, prepared comestible vegetable products, any other prepared comestible horticultural products including processed products; any of the above foodstuffs, milk or vegetable or other products when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; foodstuffs of animal origin, milk products, comestible vegetable products, any other comestible horticultural products when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides. Foodstuffs of plant origin and preparations made from them namely fruit desserts, fruit confectionery, foodstuffs made of vegetables, herbs, foodstuffs containing nuts, seeds used as seasoning spices, maple syrup, rice and foodstuffs containing rice, foodstuffs containing corn, ices or non-alcoholic drinks having a coffee, tea or cocoa base; cereal preparations; any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; flavourings for foodstuffs, for cereal preparations, for ices or for drinks; foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; ices including energy ices. Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base; beers; fruit drinks and fruit juices; syrups and other preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; non-alcoholic drinks, gels or beverages any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides and energy drinks and gels; non-alcoholic drinks, gels or beverages containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; drinks and gels, including energy drinks and energy gels when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides. Alcoholic beverages (except beers); alcoholic energy beverages; any of the above beverages when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides.
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
33 - Boissons alcoolisées à l'exception des bières
Produits et services
Creams, lotions or other preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, any creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides. Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human or animal body; creams, lotions and other preparations for pharmaceutical or veterinary purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Fooodstuffs of animal origin, milk products, prepared comestible vegetable products, any other prepared comestible horticultural products including processed products; any of the above foodstuffs, milk or vegetable or other products when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; foodstuffs of animal origin, milk products, comestible vegetable products, any other comestible horticultural products when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides. Foodstuffs of plant origin and preparations made from them namely fruit desserts, fruit confectionery, foodstuffs made of vegetables, herbs, foodstuffs containing nuts, seeds used as seasoning spices, maple syrup, rice and foodstuffs containing rice, foodstuffs containing corn, ices or non-alcoholic drinks having a coffee, tea or cocoa base; cereal preparations; any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; flavourings for foodstuffs, for cereal preparations, for ices or for drinks; foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body, ices, including energy ices. Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base; beers; fruit drinks and fruit juices; syrups and other preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; non-alcoholic drinks, gels or beverages any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides and energy drinks and gels; non-alcoholic drinks, gels or beverages containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; drinks and gels including energy drinks and energy gels when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides. Alcoholic beverages (except beers); alcoholic energy beverages; any of the above beverages when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides.
GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE (USA)
Inventeur(s)
Clarke, Kieran
Veech, Richard Lewis
Abrégé
A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 31/357 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant plusieurs atomes d'oxygène dans le même cycle, p. ex. éthers en couronne, guanadrel
A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
73.
Ketone bodies to protect tissues from damage by ionizing radiation
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (USA)
Inventeur(s)
Veech, Richard L.
Clarke, Kieran
Abrégé
Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.
Ketone bodies and ketone body esters maintain or improve muscle power output upon oral administration. Certain esters of hydroxybutyrate monomers are organoleptically acceptable and have high levels of uptake from the gut to the blood thereby allowing a rapid increase of blood concentration of hydroxybutyrate and beneficial physiological response including improved power output during exercise. Compositions containing the ketone bodies or ketone body esters are also described.
A61K 31/351 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle non condensés avec un autre cycle
A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine
Use of a ketone body and a ketone body ester for preserving glycogen and/or protein, thereby reducing muscle breakdown and improving endurance during exercise and promoting muscle recovery following exercise. Also for retarding muscle wasting in aging and disease. (R)-3-hydroxybutyl (R)-3-hydroxybutyrate for use in reducing muscle glycogen and protein breakdown during exercise or decreasing muscle wasting in aging and disease. Certain esters of hydroxybutyrate monomers, particularly a monoester of D-β-hydroxybutyrate with R-1,3-butanediol or with glycerol to reduce muscle breakdown and aid muscle recovery after exercise or retard muscle wasting. Compositions containing the ketone bodies or ketone body esters are also described.
Use of a ketone body and a ketone body ester for preserving glycogen and/or protein, thereby reducing muscle breakdown and improving endurance during exercise and promoting muscle recovery following exercise. Also for retarding muscle wasting in aging and disease. (R)-3-hydroxybutyl (R)-3-hydroxybutyrate for use in reducing muscle glycogen and protein breakdown during exercise or decreasing muscle wasting in aging and disease. Certain esters of hydroxybutyrate monomers, particularly a monoester of D-β-hydroxybutyrate with R-1,3-butanediol or with glycerol to reduce muscle breakdown and aid muscle recovery after exercise or retard muscle wasting. Compositions containing the ketone bodies or ketone body esters are also described.
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
Produits et services
[ Foodstuffs of animal origin, namely, chicken, beef, all-natural and processed lamb; milk products, namely, cow's milk, milk, milk powder ] [ Ices or non-alcoholic drinks having a coffee, tea or cocoa base, namely, ice, Italian ice, water ice; cereal preparations, namely, processed cereals; energy ices, namely, ice containing energy enhancing ingredients; ] flavorings for foodstuffs, for ices or for drinks Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base, namely, energy shots; [ beers; fruit drinks and fruit juices; syrups for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea, or cocoa base, namely, essences for use in making soft drinks; ] energy drinks; non-alcoholic drinks, gels or beverages containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides, namely, energy drinks [ Creams, lotions or other preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, any creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides ]
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
32 - Bières; boissons non alcoolisées
30 - Aliments de base, thé, café, pâtisseries et confiseries
Produits et services
Creams, lotions or other preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, any creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides Nutritional Food And Beverage Additives For Medical Purposes In The Nature Of Food And Dietary Beverage Supplements, Nutritional Supplements For Medical Purposes, Nutraceuticals For Use As A Dietary Supplement Or Nutritional Additive To Foods For Medical Purposes In The Nature Of Food And Beverage Additives Namely, Ketone Esters for use as a dietary supplement; Dietetic Substances In The Nature Of A Dietary Supplement Containing Ketones Including Ketone Esters And Mcts (Midchain Triglycerides) For Use As An Additive To Foods For Medical Purposes, not for use in manufacturing, As A Nutraceutical For Use As A Dietary Supplement Or As A Food Additive Containing Ketone Esters, not for use in manufacturing, As Hydroxybutyrates Or Being Caloric Substitutes In The Nature Of Food And Beverage Supplements For Use As A Dietary Supplement For The Treatment Of Conditions, Namely, Alzheimer's Disease, Parkinson's Disease, Depression, Muscular Conditions, Treating, Preventing Or Aiding Recovery From Fatigue, Improving Muscle Function Efficiency And Muscular Power, Maintaining And Improving Cognitive Function, Raising Blood Ketone Levels In The Human Or Animal Body, Diabetes Or Disorder Of Glucose Metabolism, Cachexia, Neuro-Degenerative Conditions, Muscular Dystrophic States, Increasing Metabolic Efficiency And Muscular Power, Treating Or Reducing Fatigue, Reducing Muscle Damage Or Wasting, Treating Inflammatory Diseases, Aiding Or Maintaining Cognitive Function, Radiation Damage, And Pharmaceutical Preparations Containing Ketone Esters For Pharmaceutical Purposes For The Treatment Of Medical Conditions, Namely, Alzheimer's Disease, Parkinson's Disease, Depression, Muscular Conditions, Treating, Preventing Or Aiding Recovery From Fatigue, Improving Muscle Function Efficiency And Muscular Power, Maintaining And Improving Cognitive Function, Raising Blood Ketone Levels In The Human Or Animal Body, Diabetes Or Disorder Of Glucose Metabolism, Cachexia, Neuro-Degenerative Conditions, Muscular Dystrophic States, Increasing Metabolic Efficiency, Reducing Fatigue, Reducing Muscle Damage Or Wasting, Inflammatory Diseases And Radiation Damage; Nutritional Food Additives For Medical Purposes For Nutraceutical Use In The Nature Of A Dietary Supplement Adapted For Oral, Topical, Parenteral, Sublingual Or Intravenous Administration To The Human Or Animal Body Foodstuffs of animal origin, namely, chicken, beef, all-natural and processed lamb; comestible horticultural processed products, namely processed vegetables Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base, namely, energy shots; beers; fruit drinks and fruit juices; syrups for making non-alcoholic beverages other than milk products and those having a coffee, tea or cocoa base; preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea, or cocoa base, namely, essences for use in making soft drinks; energy drinks; non-alcoholic drinks, gels or beverages containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides, namely, energy drinks ice, Italian ice, water ice; cereal preparations, namely, processed cereals; ice containing energy enhancing ingredients; flavorings, other than essential oils, for foodstuffs, for ices or for drinks
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
32 - Bières; boissons non alcoolisées
30 - Aliments de base, thé, café, pâtisseries et confiseries
Produits et services
Creams, lotions or other preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, any creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides Nutritional Food And Beverage Additives For Medical Purposes In The Nature Of Food And Dietary Beverage Supplements, Nutritional Supplements For Medical Purposes, Nutraceuticals For Use As A Dietary Supplement Or Nutritional Additive To Foods For Medical Purposes In The Nature Of Food And Beverage Additives Namely, Ketone Esters for use as a dietary supplement; Dietetic Substances In The Nature Of A Dietary Supplement Containing Ketones Including Ketone Esters And Mcts (Midchain Triglycerides) For Use As An Additive To Foods For Medical Purposes, not for use in manufacturing, As A Nutraceutical For Use As A Dietary Supplement Or As A Food Additive Containing Ketone Esters, not for use in manufacturing, As Hydroxybutyrates Or Being Caloric Substitutes In The Nature Of Food And Beverage Supplements For Use As A Dietary Supplement For The Treatment Of Conditions, Namely, Alzheimer's Disease, Parkinson's Disease, Depression, Muscular Conditions, Treating, Preventing Or Aiding Recovery From Fatigue, Improving Muscle Function Efficiency And Muscular Power, Maintaining And Improving Cognitive Function, Raising Blood Ketone Levels In The Human Or Animal Body, Diabetes Or Disorder Of Glucose Metabolism, Cachexia, Neuro-Degenerative Conditions, Muscular Dystrophic States, Increasing Metabolic Efficiency And Muscular Power, Treating Or Reducing Fatigue, Reducing Muscle Damage Or Wasting, Treating Inflammatory Diseases, Aiding Or Maintaining Cognitive Function, Radiation Damage, And Pharmaceutical Preparations Containing Ketone Esters For Pharmaceutical Purposes For The Treatment Of Medical Conditions, Namely, Alzheimer's Disease, Parkinson's Disease, Depression, Muscular Conditions, Treating, Preventing Or Aiding Recovery From Fatigue, Improving Muscle Function Efficiency And Muscular Power, Maintaining And Improving Cognitive Function, Raising Blood Ketone Levels In The Human Or Animal Body, Diabetes Or Disorder Of Glucose Metabolism, Cachexia, Neuro-Degenerative Conditions, Muscular Dystrophic States, Increasing Metabolic Efficiency, Reducing Fatigue, Reducing Muscle Damage Or Wasting, Inflammatory Diseases And Radiation Damage; Nutritional Food Additives For Medical Purposes For Nutraceutical Use In The Nature Of A Dietary Supplement Adapted For Oral, Topical, Parenteral, Sublingual Or Intravenous Administration To The Human Or Animal Body Foodstuffs of animal origin, namely, chicken, beef, all-natural and processed lamb; comestible horticultural processed products, namely processed vegetables Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base, namely, energy shots; beers; fruit drinks and fruit juices; syrups for making non-alcoholic beverages other than milk products and those having a coffee, tea or cocoa base; preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea, or cocoa base, namely, essences for use in making soft drinks; energy drinks; non-alcoholic drinks, gels or beverages containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides, namely, energy drinks ice, Italian ice, water ice; cereal preparations, namely, processed cereals; ice containing energy enhancing ingredients; flavorings, other than essential oils, for foodstuffs, for ices or for drinks
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
32 - Bières; boissons non alcoolisées
30 - Aliments de base, thé, café, pâtisseries et confiseries
Produits et services
Creams, lotions or other preparations for cosmetic purposes in particular for skin care; cosmetics; cosmetics, namely, any creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides Nutritional Food And Beverage Additives For Medical Purposes In The Nature Of Food And Dietary Beverage Supplements, Nutritional Supplements For Medical Purposes, Nutraceuticals For Use As A Dietary Supplement Or Nutritional Additive To Foods For Medical Purposes In The Nature Of Food And Beverage Additives Namely, Ketone Esters for use as a dietary supplement; Dietetic Substances In The Nature Of A Dietary Supplement Containing Ketones Including Ketone Esters And Mcts (Midchain Triglycerides) For Use As An Additive To Foods For Medical Purposes, not for use in manufacturing, As A Nutraceutical For Use As A Dietary Supplement Or As A Food Additive Containing Ketone Esters, not for use in manufacturing, As Hydroxybutyrates Or Being Caloric Substitutes In The Nature Of Food And Beverage Supplements For Use As A Dietary Supplement For The Treatment Of Conditions, Namely, Alzheimer's Disease, Parkinson's Disease, Depression, Muscular Conditions, Treating, Preventing Or Aiding Recovery From Fatigue, Improving Muscle Function Efficiency And Muscular Power, Maintaining And Improving Cognitive Function, Raising Blood Ketone Levels In The Human Or Animal Body, Diabetes Or Disorder Of Glucose Metabolism, Cachexia, Neuro-Degenerative Conditions, Muscular Dystrophic States, Increasing Metabolic Efficiency And Muscular Power, Treating Or Reducing Fatigue, Reducing Muscle Damage Or Wasting, Treating Inflammatory Diseases, Aiding Or Maintaining Cognitive Function, Radiation Damage, And Pharmaceutical Preparations Containing Ketone Esters For Pharmaceutical Purposes For The Treatment Of Medical Conditions, Namely, Alzheimer's Disease, Parkinson's Disease, Depression, Muscular Conditions, Treating, Preventing Or Aiding Recovery From Fatigue, Improving Muscle Function Efficiency And Muscular Power, Maintaining And Improving Cognitive Function, Raising Blood Ketone Levels In The Human Or Animal Body, Diabetes Or Disorder Of Glucose Metabolism, Cachexia, Neuro-Degenerative Conditions, Muscular Dystrophic States, Increasing Metabolic Efficiency, Reducing Fatigue, Reducing Muscle Damage Or Wasting, Inflammatory Diseases And Radiation Damage; Nutritional Food Additives For Medical Purposes For Nutraceutical Use In The Nature Of A Dietary Supplement Adapted For Oral, Topical, Parenteral, Sublingual Or Intravenous Administration To The Human Or Animal Body Foodstuffs of animal origin, namely, chicken, beef, all-natural lamb; milk products, namely, cow's milk, milk, milk powder; comestible horticultural processed products, namely, processed vegetables Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base, namely, energy shots; beers; fruit drinks and fruit juices; syrups for making non-alcoholic beverages other than milk products and those having a coffee, tea or cocoa base; preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea, or cocoa base, namely, essences for use in making soft drinks; energy drinks; non-alcoholic drinks, gels or beverages containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides, namely, energy drinks ice, Italian ice, water ice; cereal preparations, namely, processed cereals; ice containing energy enhancing ingredients; flavorings, other than essential oils, for foodstuffs, for ices or for drinks
GOVERNMENT OF THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (USA)
Inventeur(s)
Clarke, Kieran
Veech, Richard Lewis
Abrégé
A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.
A61Q 17/00 - Préparations protectricesPréparations employées en contact direct avec la peau pour protéger des influences extérieures, p. ex. des rayons du soleil, des rayons X ou d'autres rayons nuisibles, des matériaux corrosifs, des bactéries ou des piqûres d'insectes
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
A61Q 19/00 - Préparations pour les soins de la peau
A61Q 19/08 - Préparations contre le vieillissement
05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
Produits et services
Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human or animal body; creams, lotions and other preparations for pharmaceutical or veterinary purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base; cereal preparations; any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; flavourings for foodstuffs, for cereal preparations, for ices or for drinks; foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body. Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base; beers; fruit drinks and fruit juices; syrups and other preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; non-alcoholic drinks, gels or beverages any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides and energy drinks and gels; non-alcoholic drinks or beverages containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; ices, drinks or including energy ices and energy drinks when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
Produits et services
Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human or animal body; creams, lotions and other preparations for pharmaceutical or veterinary purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base; cereal preparations; any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; flavourings for foodstuffs, for cereal preparations, for ices or for drinks; foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body. Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base; when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; beers; fruit drinks and fruit juices when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; syrups and other preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; non-alcoholic drinks, gels or beverages any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides and energy drinks and gels; non-alcoholic drinks or beverages containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; ices, drinks or including energy ices and energy drinks when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
Produits et services
Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human or animal body; creams, lotions and other preparations for pharmaceutical or veterinary purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base; cereal preparations; any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; flavourings for foodstuffs, for cereal preparations, for ices or for drinks; foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body. Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base; beers; fruit drinks and fruit juices; syrups and other preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; non-alcoholic drinks, gels or beverages any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides and energy drinks and gels; non-alcoholic drinks or beverages containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; ices, drinks or including energy ices and energy drinks when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Nutritional additives for use in pharmaceutical preparations; dietetic substances for use in pharmaceutical preparations; pharmaceutical preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical preparations; hydroxybutyrates for use as additives in pharmaceutical preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human body; creams, lotions and other preparations for pharmaceutical purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human body.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
Produits et services
Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human or animal body; creams, lotions and other preparations for pharmaceutical or veterinary purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base; cereal preparations; any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; flavourings for foodstuffs, for cereal preparations, for ices or for drinks; foodstuffs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body. Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base; beers; fruit drinks and fruit juices; syrups and other preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; non-alcoholic drinks, gels or beverages any of the above foodstuffs and preparations made from them when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides and energy drinks and gels; non-alcoholic drinks or beverages containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; ices, drinks or including energy ices and energy drinks when containing ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Nutritional additives for use in pharmaceutical preparations; dietetic substances for use in pharmaceutical preparations; pharmaceutical preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical preparations; hydroxybutyrates for use as additives in pharmaceutical preparations; mid-chain triglycerides (MCT) for use as additives in pharmaceutical preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating, preventing or aiding recovery from fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function, or for raising blood ketone levels in the human body; creams, lotions and other preparations for pharmaceutical purposes in particular for skin treatments including creams, lotions or other preparations when containing or used in combination with ketone body esters in particular hydroxybutyrates and/or mid-chain triglycerides; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human body.
88.
KETONE BODIES TO PROTECT TISSUES FROM DAMAGE BY IONIZING RADIATION
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES AND HUMAN SERVICES (USA)
TDELTAS (Royaume‑Uni)
Inventeur(s)
Veech, Richard, L.
Clarke, Kieran
Abrégé
Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and/or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.
Ketone bodies and ketone body esters maintain or improve muscle power output upon oral administration. Certain esters of hydroxybutyrate monomers are organoleptically acceptable and have high levels of uptake from the gut to the blood thereby allowing a rapid increase of blood concentration of hydroxybutyrate and beneficial physiological response including improved power output during exercise. Compositions containing the ketone bodies or ketone body esters are also described.
An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.
A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine
A01N 37/02 - Acides carboxyliques saturés ou leurs thio-analoguesLeurs dérivés
A61K 47/06 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite
A23C 9/154 - Préparations à base de laitLait en poudre ou préparations à base de lait en poudre comportant des additifs contenant des substances épaississantes, des œufs ou des préparations à base de céréalesLait gélifié
A23L 27/00 - ÉpicesAgents aromatiques ou condimentsÉdulcorants artificielsSels de tableSubstituts diététiques du selLeur préparation ou leur traitement
05 - Produits pharmaceutiques, vétérinaires et hygièniques
29 - Viande, produits laitiers et aliments préparés ou conservés
30 - Aliments de base, thé, café, pâtisseries et confiseries
32 - Bières; boissons non alcoolisées
33 - Boissons alcoolisées à l'exception des bières
Produits et services
Nutritional additives or supplements for medical purposes, nutraceutical use or as a food in the nature of a dietary supplement or additive for use in pharmaceutical or veterinary preparations; dietetic substances in the nature of a dietary supplement or additive for medical purposes, nutraceutical use or as a food for use in pharmaceutical or veterinary preparations, [ esters including ] ketone body esters for use as non-chemical additives in pharmaceutical and veterinary preparations hydroxybutyrates in the nature of a dietary supplement for use as non-chemical additives in pharmaceutical and veterinary preparations; nutritional additives for medical purposes, nutraceutical use or as a food in the nature of a dietary supplement or additive containing components for raising blood ketone levels in the human or animal body; nutritional additives for medical purposes, nutraceutical use or as a food in the nature of a dietary supplements for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; nutritional additives for medical purposes, nutraceutical use or as a food in the nature of a dietary supplement for treating muscular conditions including treating or preventing fatigue, improving muscle function efficiency and muscular power, reducing or retarding muscle wastage and in maintaining or improving cognitive function; nutritional additives for medical purposes, nutraceutical use or as a food in the nature of a dietary supplement when adapted for oral, topical, sublingual or intravenous administration to the human or animal body [ Foodstuffs of animal origin, namely, chicken, beef, lamb; milk products, namely, cow's milk, milk, milk powder; comestible vegetable processed products, namely, processed vegetables; comestible horticultural processed products namely, processed vegetables ] [ ices or non-alcoholic drinks having a coffee, tea or cocoa base, namely, ice, iItalian ice, water ice; cereal preparations, namely, processed cereals; energy ices, namely, ice containing energy enhancing ingredients; ] flavorings for foodstuffs, [ for ices or ] for drinks Non-alcoholic drinks and gels other than milk products and those having a coffee, tea or cocoa base, namely, energy shots; [ beers; fruit drinks and fruit juices; syrups for making non-alcoholic drinks other than milk products and those having a coffee, tea or cocoa base; preparations for making non-alcoholic drinks other than milk products and those having a coffee, tea, or cocoa base, namely, essences for use in making soft drinks; ] energy drinks; non-alcoholic drinks, gels or beverages containing ketone body esters in particular hydroxybutyrates, namely, energy drinks [ Alcoholic beverages except beers; alcoholic energy beverages containing ketone body esters in particular hydroxybutyrates ]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
33 - Boissons alcoolisées à l'exception des bières
Produits et services
Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating or preventing fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body; foodstuffs of animal origin, milk products, comestible vegetable products, any other comestible horticultural products when containing ketone body esters in particular hydroxybutyrates; foodstufs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea, or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates; non-acoholic drinks or beverages or cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Alcoholic beverages (except beers); alcoholic energy beverages any of the above beverages when containing ketone body esters in particular hydroxybutyrates.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
33 - Boissons alcoolisées à l'exception des bières
Produits et services
Nutritional additives for use in pharmaceutical or veterinary preparations; dietetic substances for use in pharmaceutical or veterinary preparations; pharmaceutical and veterinary preparations including such preparations in the form of foods, ices, drinks, infusions, syrups, toffees, chewing gums tablets or ointments; esters including ketone body esters for use as additives in pharmaceutical and veterinary preparations; hydroxybutyrates for use as additives in pharmaceutical and veterinary preparations; any of the above additives or preparations when containing components for raising blood ketone levels in the human or animal body; any of the above additives or preparations for treating medical conditions including vascular conditions, weight loss, diabetes, heart failure, sickle cell anaemia, trauma, administration pre-surgery or post-surgery, use in intensive care treatment and conditions of the brain including Alzheimer's disease, Parkinson's disease, depression; any of the above additives or preparations for muscular conditions including treating or preventing fatigue, improving muscle function efficiency and muscular power and in maintaining or improving cognitive function; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body; foodstuffs of animal origin, milk products, comestible vegetable products, any other comestible horticultural products when containing ketone body esters in particular hydroxybutyrates; foodstufs of plant origin and preparations made from them, ices or non-alcoholic drinks having a coffee, tea, or cocoa base which foodstuffs and drinks contain components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body or when containing ketone body esters in particular hydroxybutyrates; non-acoholic drinks or beverages or cereal preparations containing components for preventing, treating or aiding recovery from fatigue, for increasing muscle function efficiency or for raising blood ketone levels in the human or animal body; any of the above additives or preparations when adapted for oral, topical, sublingual or intravenous administration to the human or animal body. Alcoholic beverages (except beers); alcoholic energy beverages any of the above beverages when containing ketone body esters in particular hydroxybutyrates.
An organoleptically acceptable composition containing a ketone body or a ketone body precursor including a hydroxybutyrate ester and a flavouring is provided and gives improved palatability and user adherence to the intended dose regime. The flavouring may be a bitter flavouring and the composition may further contain an adsorbent for the ketone such that on ingestion, the bitterness of the composition may be masked. The composition may be in the form of a solid, gel or liquid and provides increased blood ketone levels and may be used in therapy or in treating muscle impairment or fatigue.
C07C 69/675 - Esters d'acides carboxyliques dont le groupe carboxyle estérifié est lié à un atome de carbone acyclique et dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide d'acides saturés d'acides hydroxycarboxyliques saturés
A23L 1/30 - contenant des additifs (A23L 1/308 a priorité);;
A61K 31/22 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
C07C 69/66 - Esters d'acides carboxyliques dont le groupe carboxyle estérifié est lié à un atome de carbone acyclique et dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide
3 Nutraceutical and pharmaceutical compositions are provided for use in treating one or more of acute trauma, hemorrhagic shock, neurodegeneration, diabetes, and epilepsy, stroke, head trauma, myocardial infraction, congestive heart failure, pulmonary failure, kidney failure, obesity depression, pain and impaired cognition.
C07C 69/66 - Esters d'acides carboxyliques dont le groupe carboxyle estérifié est lié à un atome de carbone acyclique et dont l'un des groupes OH, O-métal, —CHO, céto, éther, acyloxy, des groupes , des groupes ou des groupes se trouve dans la partie acide
A61K 31/215 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif