A soft capsule used in smokeless tobacco products for oral use,
said soft capsule comprising a capsule film and a content encapsulated by the capsule film, wherein
the fracture hardness is 20 N or more and 200 N or less, and
the disintegration time is less than 5 minutes as measured by the disintegration test method specified in the Japanese Pharmacopoeia.
A24B 15/28 - Traitement du tabac ou des succédanés du tabac par des substances chimiques
A24B 13/00 - Tabac pour pipes, pour cigares, p. ex. éléments rapportés dans ceux-ci, ou pour cigarettesTabac à chiquerPoudre à priser
A24B 15/34 - Traitement du tabac ou des succédanés du tabac par des substances chimiques par des substances organiques comportant un carbocycle autre qu'un cycle aromatique à six chaînons
A24B 15/28 - Traitement du tabac ou des succédanés du tabac par des substances chimiques
A24B 15/167 - Caractéristiques chimiques du tabac ou des succédanés du tabac des succédanés du tabac sous forme liquide ou vaporisable, p. ex. compositions liquides pour cigarettes électroniques
A24B 15/32 - Traitement du tabac ou des succédanés du tabac par des substances chimiques par des substances organiques par des composés acycliques
A24B 15/34 - Traitement du tabac ou des succédanés du tabac par des substances chimiques par des substances organiques comportant un carbocycle autre qu'un cycle aromatique à six chaînons
A24D 3/06 - Emploi de matériaux particuliers pour les filtres à fumée de tabac
A24D 3/14 - Emploi de matériaux particuliers pour les filtres à fumée de tabac de matériaux organiques comme matériaux additionnels
3.
ABSORPTION-PROMOTING GRANULATED MATERIAL, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITION, AND COMBINED PREPARATION
Provided are a granulated material and others which can provide novel application methods for absorption promoters. This absorption-promoting granulated material includes a core particle A that contains an absorption promoter and a coating particle layer A that coats the core particle.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/28 - Stéroïdes, p. ex. cholestérol, acides biliaires ou acide glycyrrhétinique
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
The present invention addresses the problem of improving the moldability of a capsule film material (e.g., a soft capsule film material) containing a vegetable protein so as to impart a new function to a capsule preparation. Examples of the new function include: a function to make the capsule film exhibit various biological activities; a function to achieve a system (DDS; drug delivery system) for delivering an active ingredient of a capsule preparation to the intestines, particularly the large intestine; and a function to enable the use of a highly active drug as a content. As a solution for the problem, a composition for the production of a capsule film is provided, the composition comprising a vegetable-derived protein and at least one component selected from the group consisting of a polyol, a triester and a trialkylamino acid. The composition for the production of a capsule film is subjected to pressure heating treatment to provide a material for the production of a capsule film, and the material for the production of a capsule film can be formed as a capsule for a capsule preparation (preferably a soft capsule preparation).
To provide a soft capsule or the like which is chewable, and in which deformation is suppressed. The soft capsule includes a film, and contents including a first gelling agent, an oil/fat, and an emulsifier.
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A23L 5/00 - Préparation ou traitement des aliments ou produits alimentaires en généralAliments ou produits alimentaires ainsi obtenusLeurs matériaux
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
A24B 15/167 - Caractéristiques chimiques du tabac ou des succédanés du tabac des succédanés du tabac sous forme liquide ou vaporisable, p. ex. compositions liquides pour cigarettes électroniques
A24B 15/18 - Traitement du tabac ou des succédanés du tabac
A24B 15/34 - Traitement du tabac ou des succédanés du tabac par des substances chimiques par des substances organiques comportant un carbocycle autre qu'un cycle aromatique à six chaînons
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals; glue and adhesives for industrial purposes; plant
growth regulating preparations; fertilizers; higher fatty
acids; reagent paper, other than for medical or veterinary
purposes; artificial sweeteners; flour and starch for
industrial purposes. Pharmaceutical preparations and preparations for destroying
vermin; fungicides; herbicides; dietary supplements for
human beings; empty capsules for pharmaceuticals; dietetic
beverages adapted for medical purposes; dietetic foods
adapted for medical purposes; beverages for babies; food for
babies; dietary supplements for animals; reagent paper for
medical purposes; oiled paper for medical purposes; adhesive
tapes for medical purposes; drug delivery agents in the form
of edible wafers for wrapping powdered pharmaceuticals;
gauze for dressings; eyepatches for medical purposes; ear
bandages; menstruation bandages; menstruation tampons;
sanitary napkins; sanitary panties; absorbent cotton;
adhesive plasters; bandages for dressings; liquid bandages;
breast-nursing pads; cotton swabs for medical use; dental
materials; diapers; diaper covers; fly catching paper;
mothproofing paper; lacteal flour for babies; semen for
artificial insemination. Sanitary masks; medical apparatus and instruments. Food processing; providing information in the field of food
manufacturing; food grinding; processing of health foods;
providing information relating to processing of health
foods; processing of raw materials for the manufacture of
food and beverages; processing of foods and dietetic foods
adapted for medical purposes; processing of functional
foods; processing of soft capsules and other pharmaceutical
preparations, for others; custom manufacture and processing
of pharmaceuticals; information and advisory services in the
field of custom manufacture and processing of
pharmaceuticals; processing of pharmaceuticals; information
and advisory services in the field of processing of
pharmaceuticals. Testing, inspection or research of pharmaceuticals,
cosmetics or foodstuffs; computer software design, computer
programming, or maintenance of computer software; providing
computer programs on data networks; quality control of
pharmaceutical preparations; providing information relating
to study and development of pharmaceuticals for others via
the internet; research and development of vaccines and
medicines; development of pharmaceutical preparations for
others; research and development of pharmaceutical
preparations; providing information in the field of research
and development of pharmaceutical preparations; software as
a service (saas).
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry; glue and adhesives for industrial purposes; plant growth regulating preparations; fertilizers; higher fatty acids for industrial purposes; reagent paper, other than for medical or veterinary purposes; artificial sweeteners for industrial purposes; flour and starch for industrial purposes Pharmaceutical preparations for destroying vermin, fungicides, herbicides; preparations for destroying vermin; fungicides; herbicides; dietary supplements for human beings; empty capsules for pharmaceuticals; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; beverages for babies, namely, liquid formula milk for babies; food for babies; dietary supplements for animals; reagent paper for medical purposes; oiled paper for medical purposes; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; gauze for dressings; eyepatches for medical purposes; ear bandages; menstruation bandages; menstruation tampons; sanitary napkins; sanitary panties; absorbent cotton for medical purposes; adhesive plasters for medical purposes; bandages for dressings; liquid bandages for skin wounds; breast-nursing pads; cotton swabs for medical use; dental materials, namely, dental composite materials; diapers, namely, baby diapers, adult diapers; infant diaper covers; fly catching paper; mothproofing paper; lacteal flour for babies; semen for artificial insemination Sanitary masks Food processing; providing information in the field of food manufacturing; food grinding; processing of health foods; providing information relating to processing of health foods; processing of raw materials for the manufacture of food and beverages; processing of foods and dietetic foods adapted for medical purposes; processing of functional foods; processing of soft capsules and other pharmaceutical preparations, for others; custom manufacture and processing of pharmaceuticals; information and advisory services in the field of custom manufacture and processing of pharmaceuticals; processing of pharmaceuticals; information and advisory services in the field of processing of pharmaceuticals. Testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; computer software design, computer programming, and maintenance of computer software; providing online non-downloadable computer programs on data networks for database management in the field of pharmaceutical products; quality control of pharmaceutical preparations; providing information relating to study and development of pharmaceuticals for others via the internet; research and development of vaccines and medicines; development of pharmaceutical preparations for others; research and development of pharmaceutical preparations; providing information in the field of research and development of pharmaceutical preparations; software as a service (saas) featuring software for database management in the field of pharmaceutical products.
9.
SELF-EMULSIFYING COMPOSITION AND PRODUCTION METHOD THEREOF
Provided is a self-emulsifying formulation or the like in a novel form, capable of forming a dosage form such as tablets. A self-emulsifying composition comprising a core particle and a coating particle layer that coats the core particle, the core particle containing a useful substance, an oily component, a surfactant and a thickener.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
10.
ORAL PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING PARTICULATE FORMULATION COMPRISING COMPOSITION
Provided is an oral pharmaceutical composition characterized by containing a medicinal ingredient (A), a hydrophobic liquid (B), a water-soluble macromolecular substance (C), and an excipient (D), but not containing a surfactant, wherein: the medicinal ingredient (A) is included in the hydrophobic liquid (B); and the hydrophobic liquid (B) is dispersed in a composition including the water-soluble macromolecular substance (C) and the excipient (D). The oral pharmaceutical composition: allows easy dose-adjustment; has excellent dosability and safety; is biologically equivalent to a standard formulation having established profiles regarding efficacy, safety, etc.; and can be easily produced.
A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p. ex. rapamycine
A61K 31/549 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec au moins un azote et au moins un soufre comme hétéro-atomes d'un cycle, p. ex. sulthiame ayant plusieurs atomes d'azote dans le même cycle, p. ex. hydrochlorothiazide
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals; glue and adhesives for industrial purposes; plant
growth regulating preparations; fertilizers; higher fatty
acids; reagent paper, other than for medical or veterinary
purposes; artificial sweeteners; flour and starch for
industrial purposes. Pharmaceutical preparations and preparations for destroying
vermin, fungicides, herbicides; dietary supplements for
human beings; empty capsules for pharmaceuticals; dietetic
beverages adapted for medical purposes; dietetic foods
adapted for medical purposes; beverages for babies; food for
babies; dietary supplements for animals; reagent paper for
medical purposes; oiled paper for medical purposes; adhesive
tapes for medical purposes; drug delivery agents in the form
of edible wafers for wrapping powdered pharmaceuticals;
gauze for dressings; eyepatches for medical purposes; ear
bandages; menstruation bandages; menstruation tampons;
sanitary napkins; sanitary panties; absorbent cotton;
adhesive plasters; bandages for dressings; liquid bandages;
breast-nursing pads; cotton swabs for medical use; dental
materials; diapers; diaper covers; fly catching paper;
mothproofing paper; lacteal flour for babies; semen for
artificial insemination. Sanitary masks. Food processing; providing information in the field of food
manufacturing; food grinding; processing of health foods;
providing information relating to processing of health
foods; processing of raw materials for the manufacture of
food and beverages; processing of foods and dietetic foods
adapted for medical purposes; processing of functional
foods; processing of soft capsules and other pharmaceutical
preparations, for others; custom manufacture and processing
of pharmaceuticals; information and advisory services in the
field of custom manufacture and processing of
pharmaceuticals; processing of pharmaceuticals; information
and advisory services in the field of processing of
pharmaceuticals. Testing, inspection or research of pharmaceuticals,
cosmetics or foodstuffs; computer software design, computer
programming, or maintenance of computer software; providing
computer programs on data networks; quality control of
pharmaceutical preparations; providing information relating
to study and development of pharmaceuticals for others via
the internet; research and development of vaccines and
medicines; development of pharmaceutical preparations for
others; research and development of pharmaceutical
preparations; providing information in the field of research
and development of pharmaceutical preparations; software as
a service (saas).
Provided is an aroma member of a novel embodiment. The aroma member includes: a capsule-containing substrate that includes a substrate and a breakable capsule that is held by the substrate and that encapsulates a liquid aromatic agent; a first liquid barrier layer that is disposed on one surface of the capsule-containing substrate; and a second liquid barrier layer that is disposed on the other surface of the capsule-containing substrate.
Provided is a novel soft capsule. The soft capsule has a shell comprising gellan gum, wherein the soft capsule satisfies the following requirements: (A) the soft capsule has a disintegration time of 60 minutes or less as measured by a disintegration test method specified in the Japanese Pharmacopoeia using water as a test medium; and/or (B) the soft capsule has a ratio of a crush strength (g) to an outer diameter. (mm) (crush strength/outer diameter ratio) of 210 or more.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Pharmaceutical preparations and other preparations for
destroying vermin, fungicides, herbicides; dietary
supplements for human beings; empty capsules for
pharmaceuticals; dietetic beverages adapted for medical
purposes; dietetic foods adapted for medical purposes;
beverages for babies; food for babies; dietary supplements
for animals. Food processing; processing of foods and dietetic foods
adapted for medical purposes; processing of soft capsels and
other pharmaceutical preparations, for others; custom
manufacture and preparation of pharmaceuticals; information
and advisory services in the field of custom manufacture and
preparation of pharmaceuticals; processing of
pharmaceuticals; information and advisory services in the
field of processing of pharmaceuticals; processing of
functional foods; providing information in the field of food
manufacturing; processing of health foods; providing
information relating to processing of health foods.
15.
PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING SAME
Provided is a pharmaceutical composition or the like having a new form that can be orally administered even when the contained medicinal effect component is a medicinal effect component such as a high molecular weight component. This pharmaceutical composition includes: a core particle containing a medicinal effect component and an absorption promoting agent; and a coating particle layer that coats the core particle.
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/20 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant du soufre, p. ex. sulfoxyde de diméthyle [DMSO], docusate, laurylsulfate de sodium ou acides aminosulfoniques
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61K 47/28 - Stéroïdes, p. ex. cholestérol, acides biliaires ou acide glycyrrhétinique
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
Produits et services
Pharmaceutical preparations and other preparations for destroying vermin; fungicides; herbicides; dietary supplements for human beings; capsules sold empty for pharmaceuticals; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; beverages for babies, namely, liquid formula milk for babies; food for babies; dietary supplements for animals Food processing; processing of foods and dietetic foods adapted for medical purposes; processing of soft capsules and other pharmaceutical preparations, for others being custom manufacture of pharmaceuticals; custom manufacture of pharmaceuticals; custom manufacture, namely, preparation of pharmaceuticals; information and advisory services in the field of custom manufacture of pharmaceuticals; information and advisory services in the field of custom manufacture, namely, preparation of pharmaceuticals; processing of pharmaceuticals being custom manufacture of pharmaceuticals; information and advisory services in the field of processing of pharmaceuticals being custom manufacture of pharmaceuticals; processing of functional foods; providing information in the field of food manufacturing; processing of health foods; providing information relating to processing of health foods
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
40 - Traitement de matériaux; recyclage, purification de l'air et traitement de l'eau
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Chemicals used in industry; glue and adhesives for industrial purposes; plant growth regulating preparations; fertilizers; higher fatty acids for industrial purposes; reagent paper, other than for medical or veterinary purposes; artificial sweeteners for industrial purposes; flour and starch for industrial purposes Pharmaceutical preparations for destroying vermin, fungicides, herbicides; preparations for destroying vermin, fungicides, herbicides; dietary supplements for human beings; empty capsules for pharmaceuticals; dietetic beverages adapted for medical purposes; dietetic foods adapted for medical purposes; beverages for babies, namely, liquid formula milk for babies; food for babies; dietary supplements for animals; reagent paper for medical purposes; oiled paper for medical purposes; adhesive tapes for medical purposes; drug delivery agents in the form of edible wafers for wrapping powdered pharmaceuticals; gauze for dressings; eyepatches for medical purposes; ear bandages; menstruation bandages; menstruation tampons; sanitary napkins; sanitary panties; absorbent cotton for medical purposes; adhesive plasters for medical purposes; bandages for dressings; liquid bandages for skin wounds; breast-nursing pads; cotton swabs for medical use; dental materials, namely, dental composite materials; diapers, namely, baby diapers, adult diapers; infant diaper covers; fly catching paper; mothproofing paper; lacteal flour for babies; semen for artificial insemination Sanitary masks Food processing; providing information in the field of food manufacturing; food grinding; processing of health foods; providing information relating to processing of health foods; processing of raw materials for the manufacture of food and beverages; processing of foods and dietetic foods adapted for medical purposes; processing of functional foods; processing of soft capsules and other pharmaceutical preparations, for others; custom manufacture and processing of pharmaceuticals; information and advisory services in the field of custom manufacture and processing of pharmaceuticals; processing of pharmaceuticals; information and advisory services in the field of processing of pharmaceuticals Testing, inspection or research of pharmaceuticals, cosmetics or foodstuffs; computer software design, computer programming, and maintenance of computer software; providing online non-downloadable computer programs on data networks for database management in the field of pharmaceutical products; quality control of pharmaceutical preparations; providing information relating to study and development of pharmaceuticals for others via the internet; research and development of vaccines and medicines; development of pharmaceutical preparations for others; research and development of pharmaceutical preparations; providing information in the field of research and development of pharmaceutical preparations; software as a service (saas) featuring software for database management in the field of pharmaceutical products
18.
COMPOSITION FOR TREATING VASCULAR DISEASE, COMPOSITION FOR REVENTING VASCULAR DISEASE, COMPOSITION FOR TREATING HYPERTENSION, AND COMPOSITION FOR PREVENTING HYPERTENSION
Provided is a composition for the treatment of vascular disease, for the prevention of vascular disease, for the treatment of hypertension or for the prevention of hypertension, comprising caryophyllene.
A composition for treating or preventing respiratory diseases, a composition for improving sleep or promoting sleep onset, a composition for reducing fatigue, a composition for improving complexion, a composition for improving skin texture, a composition for treating or preventing periodontal disease, and a composition for controlling halitosis, each composition containing caryophyllene.
Provided are a novel agent or composition and others.
Provided are a novel agent or composition and others.
The agent or composition comprises caryophyllene and is used for at least one selected from the following (purposes) (1) to (3) :
(1) promoting relaxation, prolonging a resting-state time, and/or prolonging a motionless time,
(2) promoting sleep, and
(3) preventing blood pressure elevation.
Provided are a novel agent or composition and others.
The agent or composition comprises caryophyllene and is used for at least one selected from the following (purposes) (1) to (3) :
(1) promoting relaxation, prolonging a resting-state time, and/or prolonging a motionless time,
(2) promoting sleep, and
(3) preventing blood pressure elevation.
The present invention also relates to a method for inhaling β-caryophyllene simultaneously with smoking a tobacco product, characterized in that the tobacco product contains a β-caryophyllene-containing seamless capsule in a tobacco filter, wherein the seamless capsule contains an essential oil containing β-caryophyllene as an active ingredient. The applicants found that pulmonary inhalation of β-caryophyllene by the above method allows β-caryophyllene to be efficiently distributed throughout the body, leading to achievements of relaxing and sleep-inducing effects, etc.
An object of the present invention is to provide is a novel composition and others. The composition comprises l-menthol and at least one ingredient (X) selected from dicarboxylic acid esters, diol esters, monocarboxylic acid esters, esters of polyols having three or more hydroxy groups, esters of polycarboxylic acids having three or more carboxyl groups, polyol ethers, polyamines, and alcohols having six or more carbon atoms.
A61K 8/33 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'oxygène
A24D 3/06 - Emploi de matériaux particuliers pour les filtres à fumée de tabac
A24D 3/04 - Filtres à fumée de tabac caractérisés par leur forme ou leur structure
A24B 15/34 - Traitement du tabac ou des succédanés du tabac par des substances chimiques par des substances organiques comportant un carbocycle autre qu'un cycle aromatique à six chaînons
A23L 27/10 - Épices, agents aromatiques ou condiments naturelsLeurs extraits
Provided is a soft capsule to be used in a smokeless tobacco product for oral use, the soft capsule comprising a capsule coating film and a content encapsulated by the capsule coating film, and the soft capsule having breaking hardness of 20 N to 200 N inclusive and a disintegration time of shorter than 5 minutes when measured by the disintegration test method as prescribed in Japanese Pharmacopoeia.
A24B 15/34 - Traitement du tabac ou des succédanés du tabac par des substances chimiques par des substances organiques comportant un carbocycle autre qu'un cycle aromatique à six chaînons
A24B 13/00 - Tabac pour pipes, pour cigares, p. ex. éléments rapportés dans ceux-ci, ou pour cigarettesTabac à chiquerPoudre à priser
23.
PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING SAME
Provided is a pharmaceutical composition or the like in a new mode and having an enteric coating. This pharmaceutical composition includes: a core particle containing dietary fibers and a medicinal ingredient; and a particle coating layer that covers the core particle.
A61K 31/635 - Composés contenant des groupes para-N-benzènesulfonyl-N-, p. ex. sulfanilamide, p-nitrobenzènesulfonohydrazide contenant un hétérocycle, p. ex. sulfadiazine
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 9/72 - Préparations médicinales caractérisées par un aspect particulier à fumer ou inhaler
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
C07C 13/32 - Hydrocarbures polycycliques ou leurs dérivés hydrocarbonés acycliques à cycles condensés
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 9/72 - Préparations médicinales caractérisées par un aspect particulier à fumer ou inhaler
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/44 - Huiles, graisses ou cires couvertes par plus d’un des groupes Huiles, graisses ou cires naturelles ou naturelles modifiées, p. ex. huile de ricin, huile de ricin polyéthoxylée, cire de lignite, lignite, gomme-laque, colophane, cire d’abeille ou lanoline
C07C 13/32 - Hydrocarbures polycycliques ou leurs dérivés hydrocarbonés acycliques à cycles condensés
Provided is a capsule shell composition and the like having excellent handleability. The capsule shell composition comprises a starch, iota carrageenan, and a gum, wherein the content of the carrageenan is 2 mass% or higher with respect to the capsule shell composition, which is taken as 100 mass%, and the content of the gum is 0.3-14 mass% with respect to the capsule shell composition, which is taken as 100 mass%.
Provided are a tablet and a method for producing the tablet, in particular, a technique for tablet production whereby the amount of an active ingredient to be contained in the tablet can be stably regulated without the need of a huge cost for the production. The tablet of the present invention is one obtained by compacting a mixture comprising a granulating composition including a medicinal ingredient or a biofunctional ingredient, and includes a first region, which comprises a binder including the medicinal ingredient or biofunctional ingredient, and a second region, which is adjacent to the first region and comprises the binder including the medicinal ingredient or biofunctional ingredient. The medicinal ingredient or biofunctional ingredient contained in each of the first region and second region is included in the binder, not in the form of a layer but in the state of having been dispersed or dissolved.
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
28.
COMPOSITION FOR TREATING VASCULAR DISEASE, COMPOSITION FOR PREVENTING VASCULAR DISEASE, COMPOSITION FOR TREATING HYPERTENSION, AND COMPOSITION FOR PREVENTING HYPERTENSION
A composition for treating a vascular disease, for preventing a vascular disease, for treating hypertension or for preventing hypertension, which contains caryophyllene.
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
[Problem] The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable.
[Problem] The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable.
[Solution] A breakable seamless capsule for a smoking equipment, comprising a content containing an oily ingredient and a capsule shell for encapsulating said content, wherein:
the capsule shell contains a polysaccharide;
the thickness of the capsule shell is 60 μm or more;
the volatilization content (VC) of the content after leaving the content to stand under an environment at a temperature of 25° C. and a relative humidity of 40% for 4 hours is 3.0 wt % or more with respect to the total weight of the encapsulated content; and
the crush strength per diameter of the capsule is 3-8 N/mm. In one embodiment, the crush strength per diameter of the capsule is 3.5-8 N/mm. In another embodiment, the capsule shell does not contain gelatin.
Provided are a novel composition and others. The composition comprises l-menthol and at least one component (X) selected from a dicarboxylic acid ester, a diol ester, a monocarboxylic acid ester, an ester of a polyol having 3 or more hydroxyl groups, an ester of a polycarboxylic acid having 3 or more carboxyl groups, a polyol ether, a polyamine, and an alcohol having 6 or more carbon atoms.
A61K 31/045 - Composés hydroxylés, p. ex. alcoolsLeurs sels, p. ex. alcoolates
A23L 5/00 - Préparation ou traitement des aliments ou produits alimentaires en généralAliments ou produits alimentaires ainsi obtenusLeurs matériaux
A24B 15/00 - Caractéristiques chimiques ou traitement du tabacSuccédanés du tabac, p. ex. sous forme liquide
A24D 3/00 - Filtres à fumée de tabac, p. ex. bouts filtrants, garnitures filtrantesFiltres spécialement adaptés aux dispositifs permettant de fumer artificiellementBouts pour cigares ou cigarettes
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 9/72 - Préparations médicinales caractérisées par un aspect particulier à fumer ou inhaler
A61K 47/08 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant de l'oxygène
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/46 - Ingrédients de constitution indéterminée ou leurs produits de réaction, p. ex. peau, os, lait, fibre de coton, coquille d’œuf, fiel de bœuf ou extraits de plante
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61Q 13/00 - Formulations ou additifs pour les préparations de parfums
32.
AGENT/COMPOSITION CONTAINING CARYOPHYLLENE, AND VARIOUS USES THEREOF
Provided are a novel agent or composition, etc. The agent or composition contains caryophyllene and is used for at least one (purpose) selected from (1)-(3) below. (1) Promotion of a relaxing effect, prolongation of rest time and/or prolongation of quiescent time. (2) Sleep promotion. (3) Suppression of blood pressure elevation. The present invention also pertains to a method for filling a seamless capsule with an essential oil having β-caryophyllene as an active ingredient and mounting the capsule on a cigarette filter, whereby the β-caryophyllene is inhaled simultaneously with smoking. The applicant discovered that by inhaling β-caryophyllene through the lungs by the above method, β-caryophyllene is efficiently distributed throughout the body, leading to a relaxing effect, a sleep-inducing effect, etc.
This is to provide a useful application of plasmalogen, which is not yet known.
This is to provide a useful application of plasmalogen, which is not yet known.
A composition contains plasmalogen for enhancing a verbal memorization ability and/or a visual memorization ability.
A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols un des composés hydroxylés ayant des atomes d'azote, p. ex. phosphatidylsérine, lécithine
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Provided is a granulation composition that comprises core grains, coating grains and a binder for binding the core grains to each other and also binding the core grains to the coating grains to thereby maintain a granular shape, characterized in that: the coating grains adhere around a main granulation body comprising the core grains and the binder; the coating grains are insoluble in the binder; the core grains and/or the binder contain a medicinal ingredient or a biofunctional ingredient; and the developed interfacial area ratio Sdr is 100-700. According to this granulation composition, a uniform granulated product which is surface-coated with the coating grains and hardly segregated can be stably obtained, even if using a dilute solution with low gel strength as the binder. By setting the gelling agent concentration in the binder at a low level to give a dilute solution, therefore, the granulation composition having excellent properties can be produced at a high productivity.
Provided is a novel soft capsule. This soft capsule has a coating containing gellan gum and satisfies the following (A) and/or (B). (A) The disintegration time of the soft capsule measured in water as a test liquid according to the disintegration test of the Japanese Pharmacopoeia is within 60 minutes. (B) The ratio (breaking strength/outer diameter) of the breaking strength (g) to the outer diameter (mm) is 210 or more.
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A23L 5/00 - Préparation ou traitement des aliments ou produits alimentaires en généralAliments ou produits alimentaires ainsi obtenusLeurs matériaux
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
36.
Shell composition and capsule using the shell composition
Provided is a shell composition that is formed with a water-insoluble powder such as starch and/or a water-soluble polymer such as dextrin as a base component, and with locust bean gum and/or xanthan gum as a gelling agent. This shell composition enables a novel shell composition which can favorably form a shell without using carrageenan, has favorable properties that enable the shell composition to substitute traditional shells that use a gelatin shell or carrageenan, and comprises a plant-derived base.
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A23L 29/219 - Amidon chimiquement modifiéProduits de réaction ou de complexation de l’amidon avec d’autres produits chimiques
A23L 29/238 - Aliments ou produits alimentaires contenant des additifsLeur préparation ou leur traitement contenant des agents gélifiants ou épaississants d'origine végétale à partir de graines, p. ex. gomme de caroube ou gomme de guar
A23L 29/269 - Aliments ou produits alimentaires contenant des additifsLeur préparation ou leur traitement contenant des agents gélifiants ou épaississants d'origine microbienne, p. ex. xanthane ou dextrane
A23P 10/30 - Mise en capsules de particules, p. ex. additifs alimentaires
37.
Seamless capsule, filter and smoking equipment containing same
The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable.
the crush strength per diameter of the capsule is 3-8 N/mm.
Provided are a tablet and a method for producing the tablet, in particular, a technique for tablet production whereby the amount of an active ingredient to be contained in the tablet can be stably regulated without the need of a huge cost for the production. The tablet of the present invention is one obtained by compacting a mixture comprising a granulating composition including a medicinal ingredient or a biofunctional ingredient, and includes a first region, which comprises a binder including the medicinal ingredient or biofunctional ingredient, and a second region, which is adjacent to the first region and comprises the binder including the medicinal ingredient or biofunctional ingredient. The medicinal ingredient or biofunctional ingredient contained in each of the first region and second region is included in the binder, not in the form of a layer but in the state of having been dispersed or dissolved.
A61K 9/26 - Particules distinctes dans une matrice support
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
39.
SEAMLESS CAPSULE, AND FILTER AND SMOKING DEVICE INCLUDING SAME
[Problem] To provide a capsule capable of disintegrating and capable of suppressing volatilization over time from a capsule film for highly-volatile capsule content. [Solution] A seamless capsule that is used in a smoking device and is capable of disintegrating, wherein the seamless capsule comprises content including an oily component, and a capsule film for encapsulating the content. The capsule film contains polysaccharides and has a thickness of at least 60 μm. The volatile content (VC) of the content at four hours when left to stand in an environment in which the temperature is 25°C and the relative humidity is 40% is 3.0% by weight relative to the total weight of the content that has been blended in. The breaking strength per capsule diameter is 3–8 N/mm. In an embodiment, the breaking strength per capsule diameter is 3.5–8 N/mm. In another embodiment, the capsule film does not include gelatin.
Provided is a capsule capable of disintegrating and capable of suppressing volatilization over time from a capsule film for highly-volatile capsule content. A seamless capsule that is used in a smoking device and is capable of disintegrating, wherein the seamless capsule comprises content including an oily component, and a capsule film for encapsulating the content. The capsule film contains polysaccharides and has a thickness of at least 60 μm. The volatile content (VC) of the content at four hours when left to stand in an environment in which the temperature is 25°C and the relative humidity is 40% is 3.0% by weight relative to the total weight of the content that has been blended. The breaking strength per capsule diameter is 3–8 N/mm.
Provided is a useful but not publicly known application of plasmalogen. This plasmalogen-containing composition is for increasing a verbal memorization ability and/or a visual memorization ability.
A23L 33/115 - Acides gras ou leurs dérivésGraisses ou huiles
A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols un des composés hydroxylés ayant des atomes d'azote, p. ex. phosphatidylsérine, lécithine
A61K 35/655 - Animaux aquatiques autres que ceux couverts par les groupes
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
Provided is a granulation composition that comprises core grains, coating grains and a binder for binding the core grains to each other and also binding the core grains to the coating grains to thereby maintain a granular shape, characterized in that: the coating grains adhere around a main granulation body comprising the core grains and the binder; the coating grains are insoluble in the binder; the core grains and/or the binder contain a medicinal ingredient or a biofunctional ingredient; and the developed interfacial area ratio Sdr is 100-700. According to this granulation composition, a uniform granulated product which is surface-coated with the coating grains and hardly segregated can be stably obtained, even if using a dilute solution with low gel strength as the binder. By setting the gelling agent concentration in the binder at a low level to give a dilute solution, therefore, the granulation composition having excellent properties can be produced at a high productivity.
A61K 47/08 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant de l'oxygène
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/22 - Composés hétérocycliques, p. ex. acide ascorbique, tocophérol ou pyrrolidones
A61K 47/32 - Composés macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. carbomères
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
Provided is a coating composition that is characterized by comprising a water-insoluble powder such as starch and/or a water-soluble polymer such as dextrin as a base component, and locust bean gum and/or xanthan gum as a gelling agent. This coating composition enables a novel coating composition to be obtained which can favorably form a coating without using carrageenan, has favorable properties that enable the coating composition to substitute traditional coatings that use a gelatin coating or carrageenan, and comprises a plant-derived base.
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A23L 5/00 - Préparation ou traitement des aliments ou produits alimentaires en généralAliments ou produits alimentaires ainsi obtenusLeurs matériaux
A23L 29/238 - Aliments ou produits alimentaires contenant des additifsLeur préparation ou leur traitement contenant des agents gélifiants ou épaississants d'origine végétale à partir de graines, p. ex. gomme de caroube ou gomme de guar
A23L 29/269 - Aliments ou produits alimentaires contenant des additifsLeur préparation ou leur traitement contenant des agents gélifiants ou épaississants d'origine microbienne, p. ex. xanthane ou dextrane
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A capsule excellent in enteric property with the assumption that gelatin is used as a main base material of the capsule coating. An alkali-treated gelatin and carrageenan are contained as base materials of the capsule coating. In the gastric (aqueous) environment, the alkali-treated gelatin which is positively (+) charged coexists with the carrageenan which is negatively (−) charged, and amino groups (NH4+) in the gelatin react with sulfate groups (SO3−) in the carrageenan so that the capsule coating is insolubilized. On the other hand, in the intestinal (aqueous) environment, the alkali-treated gelatin which is negatively (−) charged coexists with the carrageenan which is negatively (−) charged, and the amino groups (NH4+) in the gelatin are repulsive to the sulfate groups (SO3−) in the carrageenan so that the capsule coating quickly disintegrates and dissolves.
Provided is an oral pharmaceutical composition characterized by containing a medicinal ingredient (A), a hydrophobic liquid (B), a water-soluble macromolecular substance (C), and an excipient (D), but not containing a surfactant, wherein: the medicinal ingredient (A) is included in the hydrophobic liquid (B); and the hydrophobic liquid (B) is dispersed in a composition including the water-soluble macromolecular substance (C) and the excipient (D). The oral pharmaceutical composition: allows easy dose adjustment; has excellent dosability and safety; is biologically equivalent to a standard formulation having established profiles regarding efficacy, safety, etc.; and can be easily produced.
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p. ex. rapamycine
A61K 31/55 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à sept chaînons, p. ex. azélastine, pentylènetétrazole
A61K 31/706 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'azote comme hétéro-atome d'un cycle, p. ex. nucléosides, nucléotides contenant des cycles à six chaînons avec l'azote comme hétéro-atome d'un cycle
A61K 38/00 - Préparations médicinales contenant des peptides
A61K 47/08 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant de l'oxygène
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/14 - Esters d’acides carboxyliques, p. ex. acides gras monoglycérides, triglycérides à chaine moyenne, parabènes ou esters d’acide gras de PEG
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
By assuming the use of gelatin as a main base material of a capsule coating, provided is a capsule having excellent enteric properties. The enteric capsule contains alkali-treated gelatin and carrageenan as base materials of a capsule coating. In the gastric (aqueous) environment, the alkali-treated gelatin that is positively (+) charged coexists with the carrageenan that is negatively (-) charged and amino (NH4+) group in the gelatin reacts with sulfate (SO3-) group in the carrageenan so that the capsule coating is insolubilized. Meanwhile, in the enteric (aqueous) environment, the alkali-treated gelatin that is negatively (-) charged coexists with the carrageenan that is also negatively (-) charged and amino (NH4+) group in the gelatin repulses with sulfate (SO3-) group in the carrageenan so that the capsule coating quickly disintegrates and dissolves.
wherein (Y) represents distance/outer diameter ratio, where the distance represents the distance (mm) that is deformed to reach the maximum load, when the capsule is ruptured over the press under the condition of 22° C., 80% RH.
The purpose of the present invention is to provide a collapsible capsule for which: the capsules do not adhere to each other; the capsule contents do not change over time; the capsule has excellent heat resistance and moisture resistance; the capsule can be broken easily when finger pressure is applied; and the capsule has a satisfying feel when broken and is able to release the contents. The present invention relates to a collapsible capsule with contents and a capsule film, the capsule being characterized in comprising oil components for the contents, comprising at least a film-forming base for the capsule film and satisfying formula (1) and formula (2). 200 < (X) < 560 (1) (in the formula, (X) represents the rupture strength (g)/outer capsule diameter (mm)) 0.20 ≤ (Y) ≤ 0.48 (2) (in the formula, (Y) represents the ratio of distance/outer diameter, said distance representing the distance (mm) to which the capsule deforms by the time maximum load is reached when the capsule is ruptured by applying a press on the capsule at 22°C and 80% RH.
The objective of the present invention is to provide a disintegrable capsule, groups of which do not adhere to each other, the contents of which does not change over time, which is heat resistant and moisture resistant, which can be easily broken by applying pressure with the fingers, which provides a pleasant sensation when broken, and the contents of which can be released. This disintegrable capsule has contents and a capsule coating film, and is characterized by including an oil component as the contents, and at least a film-forming base as the capsule coating film, and by satisfying formula (1) and formula (2). (1) 150<(X)<630 (In the formula, (X) represents breaking strength (g)/outer diameter (mm) of capsule.) (2) 0.15≤(Y)≤0.53 (In the formula, (Y) represents the distance/outer diameter ratio, where said distance represents the distance (mm) by which the capsule is deformed until the maximum load is reached when the capsule is pressed at 22℃ and 80% RH, and broken.)