The present invention addresses the problem of providing siRNA which targets a RecQL1 helicase gene and is based on a novel target sequence that brings about better effects than conventional siRNA. Provided is siRNA targeting a RecQL1 helicase gene, the siRNA comprising: a sense strand containing the base sequence represented by SEQ ID NO: 1; and an antisense strand containing the base sequence represented by SEQ ID NO: 2.
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61K 31/712 - Acides nucléiques ou oligonucléotides ayant des sucres modifiés, c.-à-d. autres que le ribose ou le 2'-désoxyribose
A61K 31/7125 - Acides nucléiques ou oligonucléotides ayant des liaisons internucléosides modifiées, c.-à-d. autres que des liaisons 3'-5' phosphodiester
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
The present invention addresses the problem of providing a stable crystal form of darinaparsin, a method for producing the same, and a formulation containing the crystal form. The present invention provides a crystal form of a compound of an alkali metal salt and/or inorganic acid addition salt of darinaparsin, or a solvate thereof. In this crystal form, the pH is 4.5-7.3 when the crystal form of an alkali metal salt and/or inorganic acid addition salt of darinaparsin, or a solvate thereof, is dissolved in purified water.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; vermin destroying preparations;
fungicides; herbicides; pharmaceutical preparations and
pharmaceuticals for the treatment of cancer; oiled paper for
medical purposes; waxed paper for medical purposes; dental
abrasives; dental adhesives; dental alloys; dental amalgams;
dental cements; dental ceramics; dental lacquer; dental
mastics; dental waxes; dental impression materials;
materials for dental fillings; adult diapers; babies'
diapers; cloth diapers; diapers for incontinence; disposable
adult diapers; disposable babies' diapers; fly catching
paper; mothproofing paper; lacteal flour for babies; dietary
supplements for humans; dietetic beverages adapted for
medical purposes; beverages for babies; dietary supplements
for animals; semen for artificial insemination. Finger guards for medical purposes; contraceptives,
non-chemical; artificial tympanic membranes; ear plugs for
sleeping; esthetic massage apparatus for use in beauty
salons; medical apparatus and instruments; electric massage
apparatus for household purposes; gloves for medical
purposes; portable hand-held urinals; urinals being vessels;
ear picks.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; vermin destroying preparations;
fungicides; herbicides; pharmaceutical preparations and
pharmaceuticals for the treatment of cancer; oiled paper for
medical purposes; waxed paper for medical purposes; dental
abrasives; dental adhesives; dental alloys; dental amalgams;
dental cements; dental ceramics; dental lacquer; dental
mastics; dental waxes; dental impression materials;
materials for dental fillings; adult diapers; babies'
diapers; cloth diapers; diapers for incontinence; disposable
adult diapers; disposable babies' diapers; fly catching
paper; mothproofing paper; lacteal flour for babies; dietary
supplements for humans; dietetic beverages adapted for
medical purposes; beverages for babies; dietary supplements
for animals; semen for artificial insemination. Finger guards for medical purposes; contraceptives,
non-chemical; artificial tympanic membranes; ear plugs for
sleeping; esthetic massage apparatus for use in beauty
salons; medical apparatus and instruments; electric massage
apparatus for household purposes; gloves for medical
purposes; portable hand-held urinals; urinals being vessels;
ear picks.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical preparations; vermin destroying preparations;
fungicides; herbicides; pharmaceutical preparations and
pharmaceuticals for the treatment of cancer; oiled paper for
medical purposes; waxed paper for medical purposes; dental
abrasives; dental adhesives; dental alloys; dental amalgams;
dental cements; dental ceramics; dental lacquer; dental
mastics; dental waxes; dental impression materials;
materials for dental fillings; adult diapers; babies'
diapers; cloth diapers; diapers for incontinence; disposable
adult diapers; disposable babies' diapers; fly catching
paper; mothproofing paper; lacteal flour for babies; dietary
supplements for humans; dietetic beverages adapted for
medical purposes; beverages for babies; dietary supplements
for animals; semen for artificial insemination. Finger guards for medical purposes; contraceptives,
non-chemical; artificial tympanic membranes; ear plugs for
sleeping; esthetic massage apparatus for use in beauty
salons; medical apparatus and instruments; electric massage
apparatus for household purposes; gloves for medical
purposes; portable hand-held urinals; urinals being vessels;
ear picks.
8.
Organoarsenic compounds and methods for the treatment of cancer
5, W and “n” are as defined in claim 1) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-1-thioglycerol.
The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides novel crystalline forms of organic arsenic compounds and methods for their use in treating cancers such as leukemia and solid tumors. Specifically, a crystalline form of darinaparsin, wherein the crystalline form has a melting point in the range of about 190-200 deg C.
C07C 229/26 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant plus d'un groupe amino lié au squelette carboné, p. ex. lysine
The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
C07C 229/26 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant plus d'un groupe amino lié au squelette carboné, p. ex. lysine
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical and veterinary preparations. Scientific and technological services and research and
design relating thereto. Medical services; veterinary services; consultancy relating
to medicines.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Pharmaceutical preparations for * local treatment of pain associated with oral mucositis that is administered through a device, * [ the treatment of inflammatory and infectious diseases and diseases in the oral cavity; Veterinary preparations for inflammatory and infectious diseases and diseases in the oral cavity for pets and livestock ] * none of the aforesaid goods in relation to gynecological pharmaceutical preparations or hygienic products related thereto * [ Scientific and technological services and research and design in the field of the development of veterinary medicines and human pharmaceuticals for the treatment of inflammatory and infectious diseases and diseases in the oral cavity ]
05 - Produits pharmaceutiques, vétérinaires et hygièniques
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical preparation for local treatment of pain associated with oral mucositis that is administrated through a device, none of the aforesaid goods in relation to gynecological pharmaceutical preparations or hygienic products related thereto. Scientific and technological services and research and design relating thereto, none of the aforesaid services in relation to gynecological pharmaceutical preparations or hygienic products related thereto. Medical services; veterinary services; consultancy relating to medicines, none of the aforesaid services in relation to gynecological pharmaceutical preparations or hygienic products related thereto.
The present invention provides organic arsenicals. Many of these compounds have potent in vitro cytotoxic activity against numerous human tumor cell lines, both of solid and hematological origin, as well as against malignant blood cells from patients with leukemia.
C07C 229/26 - Composés contenant des groupes amino et carboxyle liés au même squelette carboné ayant des groupes amino et carboxyle liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant plus d'un groupe amino lié au squelette carboné, p. ex. lysine
