The invention relates to the field of biomedicine and particularly to a hydrophobically modified antimicrobial peptide and a use thereof. The technical problem to be solved by the invention is to provide a hydrophobically modified antimicrobial peptide, the hydrophobic modification is to couple a hydrophobic fragment at the nitrogen terminal of the antimicrobial peptide. The invention further provides a micelle prepared from the hydrophobically modified antimicrobial peptide, and use of the hydrophobically modified antimicrobial peptide and the micelle in preparing antimicrobial drugs, nucleic acid transporter, immune adjuvant and the like. Due to small molecular weight, the antimicrobial peptide of the invention can be conveniently synthesized by Fmoc solid phase polypeptide, and coupled to a hydrophobic fragment by the chemical synthesis method in a simple and feasible way.
A61K 47/62 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant une protéine, un peptide ou un acide polyaminé
A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
The present application particularly relates to the technical field of water-conducting fracture zone detection. Provided are a water-conducting fracture zone detection device and method integrated with an automatic detection function. The detection device comprises: a drill pipe and an elastic water-storage pouch, wherein a head region and a tail region are provided on two sides of the drill pipe, respectively; a water supply channel is provided inside the drill pipe, a first channel is provided on the side wall of the drill pipe, and a first valve is provided inside the first channel; the drill pipe in the head region is provided with a second channel, and a first flow meter and a second valve are provided inside the water supply channel between the second channel and the elastic water-storage pouch; a water return line is provided between the head region and the tail region of the drill pipe, and the water return line runs through the elastic water-storage pouch and connects the outside of the head region of the drill pipe and the outside of the tail region of the drill pipe; and a second flow meter is provided inside the water return line. The water-conducting fracture zone detection device and method integrated with an automatic detection function provided by the present application can complete the detection of a water-conducting fracture zone while drilling, such that the labor intensity of workers can be reduced.
G01N 15/08 - Recherche de la perméabilité, du volume des pores ou de l'aire superficielle des matériaux poreux
E21B 49/00 - Test pour déterminer la nature des parois des trous de forageEssais de couchesProcédés ou appareils pour prélever des échantillons du terrain ou de fluides en provenance des puits, spécialement adaptés au forage du sol ou aux puits
E21B 47/00 - Relevés dans les trous de forage ou dans les puits
3.
METHOD FOR GENERATING INTEGRAL-IMAGING MICRO-IMAGE ARRAY ON BASIS OF OPTIMAL VOXEL SPACE DISTRIBUTION
The present invention relates to a method for generating an integral-imaging micro-image array on the basis of optimal voxel space distribution. The method comprises the steps of: acquiring depth data and texture data of a 3D scene; on the basis of the relationship between a voxel space of an integral-imaging 3D display and 3D display performance, from the entire voxel space of the integral-imaging 3D display, selecting, as an optimal voxel space, part of the voxel space which satisfies the requirements of the 3D display performance; and by using the obtained depth data and texture data of the 3D scene as inputs, on the basis of the selected optimal voxel space, synthesizing a micro-image array which satisfies the display performance requirements of the integral-imaging 3D display. The method can obtain depth data and texture data by means of existing mature technology and product, without depending on the structure of an integral-imaging display system itself; and the method flexibly adjusts the resolution of the acquired depth data and texture data by means of an optimal voxel space, and thus is suitable for integral-imaging 3D displays having different specification parameters.
H04N 13/302 - Reproducteurs d’images pour visionnement sans avoir recours à des lunettes spéciales, c.-à-d. utilisant des affichages autostéréoscopiques
H04N 13/122 - Raffinement de la perception 3D des images stéréoscopiques par modification du contenu des signaux d’images, p. ex. par filtrage ou par ajout d’indices monoscopiques de profondeur
H04N 13/128 - Ajustement de la profondeur ou de la disparité
H04N 13/139 - Conversion du format, p. ex. du débit de trames ou de la taille
Provided are a polypeptide targeting TRAF6 and use thereof. Provided is use of a polypeptide in preparing a TRAF6 inhibitor. The polypeptide comprises an amino acid sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3. The provided polypeptide can effectively inhibit TRAF6, thereby achieving the inhibition of neurodegenerative disease-related aggregates. The present disclosure has good prospects in improving, alleviating, and/or treating neurodegenerative diseases.
A61K 38/16 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
A61K 38/10 - Peptides ayant de 12 à 20 amino-acides
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
The present invention relates to the technical field of superconducting flux pumps, and relates to a superconducting flux pump having volt-level direct-current voltage output and an excitation experimental system. The superconducting flux pump uses a three-phase alternating-current core and a direct-current bias core to form a magnetically coupled air gap. After three-phase power is applied to a three-phase alternating-current winding, a generated magnetic field is conducted through the core to generate a traveling wave magnetic field at the magnetically coupled air gap. A magnetic field generated by a direct-current bias winding is conducted through the core to generate a direct-current bias magnetic field at the magnetically coupled air gap. After the traveling wave magnetic field and the direct-current bias magnetic field are superimposed, a biased traveling wave magnetic field is generated at the magnetically coupled air gap, and acts on a superconducting stator at the magnetically coupled air gap to generate a direct-current voltage output. The present invention achieves volt-level direct-current voltage output from superconducting flux pumps, significantly reduces the power supply cost of high-temperature superconducting magnets, helps to reduce the burden on refrigeration systems, and enables rapid charging of superconducting coils and operation in a continuous current mode.
Disclosed is a method for integral imaging elemental image array generation based on optimal voxel space distribution, which includes: acquiring depth data and texture data of a 3D scene; according to the relationship between a voxel space of an integral imaging 3D display and the 3D display performance, selecting a part of the voxel space that meets 3D display performance requirements from the entire voxel space of the integral imaging 3D display as the optimal voxel space; inputting the acquired depth data and texture data of the 3D scene, and synthesizing the elemental image array that meets the display performance requirements of the integral imaging 3D display according to the selected optimal voxel space. The method can obtain depth data and texture data through mature technologies and products of the prior art, and no longer relies on its own structure of an integral imaging display system integral imaging.
Disclosed is a method for preparing a biological valve material by copolymerization and crosslinking, as well as a biological valve material and use. The preparation method includes: step S110, contacting a biomaterial with an aldehyde group crosslinking agent solution for crosslinking; step S120, soaking the biomaterial treated in step S110 in a solution containing a first functional monomer for a chemical reaction to introduce a first carbon-carbon double bond, wherein the first functional monomer has the first carbon-carbon double bond and an ethylene oxide group; step S130, soaking the biomaterial treated in step S120 in a solution containing a second functional monomer, wherein the second functional monomer has a second carbon-carbon double bond and a functional group B; and step S200, performing polymerization of carbon-carbon double bonds under an action of an initiator. The method introduces carbon-carbon double bonds twice while also incorporating additional functional groups.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
Disclosed is a supply guarantee method for a power distribution network (PDN) considering demand response and dynamic reconfiguration, including the steps of: depicting a photovoltaic output, a wind turbine output and a load model according to meteorological factors of extreme high temperature weather, the meteorological factors including temperature and illumination, and constructing a user response model according to a user demand side response participation degree; and determining outage loss coefficients of different power consumption scenarios, constructing a PDN load reliable supply model based on the outage loss coefficients, and solving the PDN load reliable supply model to obtain a PDN supply guarantee strategy. The reliability requirement levels of different loads in PDN are classified to give priority to meeting the power demand of important loads, which can effectively guarantee the power consumption of users in the extreme high temperature weather and improve the reliability and economy of power grid operation.
The present discloses a guide plate structure for injecting a flowable composite resin. The guide plate structure includes a rigid guide plate shell and a soft lining, a plurality of overflow holes are formed on the guide plate shell. The guide plate shell is provided with an injection channel used for injecting a flowable composite resin. A method for manufacturing a guide plate structure for injecting a flowable composite resin is further disclosed, including: S1, manufacturing a wax pattern model; S2, manufacturing a guide plate shell; S3, manufacturing a lining; S4, correcting an edge of the guide plate shell; and S5, cleaning a soft material in an injection channel on the guide plate shell. The present disclosure can resolve the problem of difficulties in placement and displacement of a guide plate when a resin is injected to restore an undercut of a tooth, and improve molding precision of the restoration.
A61C 13/20 - Méthodes ou dispositifs pour souder, mouler, façonner ou fondre
B29C 33/38 - Moules ou noyauxLeurs détails ou accessoires caractérisés par la matière ou le procédé de fabrication
B29K 83/00 - Utilisation de polymères contenant dans la chaîne principale uniquement du silicium avec ou sans soufre, azote, oxygène ou carbone comme matière de moulage
B33Y 80/00 - Produits obtenus par fabrication additive
The present application relates to the technical field of mycelia, and discloses a mycelium growth method, a mycelium and a use. The method comprises: soaking a porous material in a nutrient solution, taking out the porous material after the porous material is fully soaked, and drying; inoculating a ganoderma lucidum strain on a macropore wall of the dried porous material for culture, so as to obtain a ganoderma lucidum strain cultured by the porous material; and placing the ganoderma lucidum strain cultured by the porous material at the bottom of a container containing the nutrient solution, partially soaking the porous material in the nutrient solution, and culturing the strain in a closed space. The porous material used in the method has a uniform structure and is beneficial to uniform growth of a hypha. The porous material has certain strength and a smooth surface, thereby facilitating the separation of the hypha and a substrate, and the activity of a grown mycelium is high.
Disclosed are a biological valve material based on aldehyde group crosslinking, a preparation method therefor, and use thereof. The preparation method includes: step S110, contacting the biological material with an aldehyde group crosslinking agent solution for crosslinking; step S120, soaking the biological material treated in step S110 in a solution containing a first functional monomer to chemically introduce first carbon-carbon double bonds; wherein the first functional monomer has the first carbon-carbon double bonds and an ethylene oxide group; step S130, soaking the biological material treated in step S120 in a solution containing a second functional monomer, wherein the second functional monomer has second carbon-carbon double bonds; and step S200, performing a polymerization reaction of the carbon-carbon double bonds under an action of an initiator to obtain a biological valve material. The method yields more and larger polymer crosslinking networks by means of two rounds of crosslinking.
The present application relates to the field of chemical drugs, and discloses a P2X7 receptor antagonist. The structure of the P2X7 receptor antagonist is as shown in formula I. The present application has found that the compound shown in formula I not only has excellent antagonistic activity for the P2X7 receptor, but also has excellent metabolic stability and pharmacokinetic properties. Compared with the positive control JNJ47965567, the metabolic stability and pharmacokinetic properties of the compound of the present application are significantly improved, and the druggability is significantly better. The compound shown in formula I is used as a P2X7 receptor antagonist, and can be used to prepare a drug for treating illnesses such as inflammation and inflammation-related diseases, kidney diseases, respiratory diseases, cancer, pain, central nervous system diseases, radiation-induced brain injury, cerebral ischemia, myocardial injury, diabetes, depression, lupus erythematosus, atherosclerosis, and allergic asthma, and has broad application prospects.
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
A61P 19/02 - Médicaments pour le traitement des troubles du squelette des troubles articulaires, p. ex. arthrites, arthroses
A61P 1/00 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
A61P 3/10 - Médicaments pour le traitement des troubles du métabolisme de l'homéostase du glucose de l'hyperglycémie, p. ex. antidiabétiques
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
13.
HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF
A heterocyclic compound, a preparation method therefor, and a use thereof are provided. The structure of the heterocyclic compound is as shown in formula (I). The compound can effectively inhibit the proliferation of squamous cell carcinoma, and provides a new choice for preparing drugs for preventing and/or treating squamous cell carcinoma.
A heterocyclic compound, a preparation method therefor, and a use thereof are provided. The structure of the heterocyclic compound is as shown in formula (I). The compound can effectively inhibit the proliferation of squamous cell carcinoma, and provides a new choice for preparing drugs for preventing and/or treating squamous cell carcinoma.
C07D 239/36 - Un atome d'oxygène lié par une liaison double ou sous forme de radical hydroxyle non substitué
C07D 239/47 - Un atome d'azote et un atome d'oxygène ou de soufre, p. ex. cytosine
C07D 239/553 - Deux atomes d'oxygène liés par une liaison double ou sous forme de radicaux hydroxyle non substitués avec d'autres hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle avec des atomes d'halogène ou avec des radicaux nitro liés directement aux atomes de carbone du cycle, p. ex. fluoro-uracile
C07D 239/557 - Deux atomes d'oxygène liés par une liaison double ou sous forme de radicaux hydroxyle non substitués avec d'autres hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle avec des atomes de carbone comportant trois liaisons à des hétéro- atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle, p. ex. acide orotique
C07D 239/60 - Trois atomes d’oxygène ou de soufre ou plus
C07D 473/04 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'oxygène
C07D 473/16 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 deux atomes d'azote
C07D 473/18 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'oxygène, de soufre ou d'azote liés directement en positions 2 et 6 un atome d'oxygène et un atome d'azote, p. ex. guanine
C07D 473/30 - Atome d'oxygène lié en position 6, p. ex. hypoxanthine
C07D 473/34 - Atome d'azote lié en position 6, p. ex. adénine
C07D 473/40 - Composés hétérocycliques contenant des systèmes cycliques purine avec des atomes d'halogènes ou des radicaux perhalogénoalkyles liés directement en position 2 ou 6
14.
Method for Intelligent Design and Application of Offshore Wind Turbine Structures Based on Sequential Knowledge Distillation and Transfer Learning
The provided is a method for intelligent design and application of offshore wind turbine structures based on sequential knowledge distillation and transfer learning. The method includes the following steps: S1, obtaining the open data set of the offshore wind turbine structures; S2, more than three random initialization lightweight network models are obtained, under the supervision of the intelligently designed artificial intelligence regression model of the offshore wind turbine structure as the teacher model, the knowledge distillation of the lightweight network model is performed to obtain the student model; S3, transfer learning is used for the student model, and the undeclared environmental parameters, wind turbine parameters and structural design parameters of the offshore wind power commercial wind turbine of the enterprise are accessed to obtain a lightweight model for the megawatt commercial wind turbine, and the regression model with the highest accuracy is screened.
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
G06F 30/13 - Conception architecturale, p. ex. conception architecturale assistée par ordinateur [CAAO] relative à la conception de bâtiments, de ponts, de paysages, d’usines ou de routes
15.
Single-pulse experimentation device based on hopkinson pressure bar and experimentation method
A single-pulse experimentation device based on a Hopkinson pressure bar and an experimentation method include an experimentation assembly and a pulse controlling assembly, the experimentation assembly includes a power generating mechanism, an incident bar and a transmission bar, a space between the incident bar and the transmission bar is for accommodating a sample, and the sample is for bearing and transferring a dynamic-loading compressional wave transmitted by the incident bar; the pulse controlling assembly includes: a stretching assembly that is internally hollow and is connected to the transmission bar; and an elastic assembly and a gear regulating mechanism that are located inside the stretching assembly, and are connected to corresponding positions of the stretching assembly, respectively; wherein the gear regulating mechanism is configured for driving the stretching assembly to switch between a first position state and a second position state.
G01N 3/30 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique en appliquant une force unique et brève
G01N 3/02 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique Parties constitutives
G01N 3/307 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique en appliquant une force unique et brève engendrée par un ressort en compression ou en extensionRecherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique en appliquant une force unique et brève engendrée par des moyens pneumatiques ou hydrauliques
16.
Magnetic flux leakage and electromagnetic acoustic transducer joint testing device and method for drill pipe at wellhead
A magnetic flux leakage and electromagnetic acoustic transducer joint testing device for a drill pipe at wellhead, including a mounting table, a limiting frame, a detection mechanism, and a signal processing mechanism. The limiting frame is mounted on the mounting table, and provided with the detection mechanism. A middle of the detection mechanism is provided with the drill pipe. The detection mechanism is connected to the signal processing mechanism. When the drill pipe passes through the detection mechanism when being lifted or lowered within the wellhead, the detection mechanism, integrating a magnetic flux leakage detection probe and an electromagnetic ultrasonic detection probe, will perform overall detection of the drill pipe. A magnetic flux leakage and electromagnetic acoustic transducer joint testing method is further provided.
G01N 27/83 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant des variables magnétiques pour rechercher la présence des criques en étudiant des champs magnétiques de dispersion
E21B 47/01 - Dispositifs pour supporter des instruments de mesure sur des trépans, des tubes, des tiges ou des câbles de forageProtection des instruments de mesure dans les trous de forage contre la chaleur, les chocs, la pression ou similaire
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
G01N 29/27 - Dispositions pour l'orientation ou le balayage en déplaçant le matériau par rapport à un capteur fixe
G01N 29/44 - Traitement du signal de réponse détecté
17.
GLYCOSYL DONOR, PREPARATION METHOD THEREFOR, AND USE THEREOF
A glycosyl donor represented by formula (I) is used for preparing an S-glycoside compound represented by formula (III), an O-glycoside compound represented by formula (V), and a C-glycoside compound represented by formula (V). The glycosyl donor is a raw material in the preparation of O-glycoside, S-glycoside, and C-glycoside compounds by means of a free radical reaction, most of which have a special α configuration.
C07D 309/08 - Composés hétérocycliques contenant des cycles à six chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle, non condensés avec d'autres cycles ne comportant pas de liaison double entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
C07D 307/18 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant un atome d'oxygène comme unique hétéro-atome du cycle non condensés avec d'autres cycles ne comportant pas de liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/14 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
C07D 407/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
METHOD FOR PREPARING BIOLOGICAL VALVE MATERIAL BY MEANS OF DOUBLE-BOND POLYMERIZATION AFTER ALDEHYDE CROSSLINKING, AS WELL AS BIOLOGICAL VALVE MATERIAL AND USE
Disclosed is a method for preparing biological valve material by means of double-bond polymerization after aldehyde crosslinking, as well as the biological valve material and use therefor. The preparation method includes: step S110, contacting the biomaterial with an aldehyde-based crosslinking agent solution for crosslinking; Step S120: soaking the biomaterial processed in Step S110 in a solution containing a first functional monomer for reaction to introduce first carbon-carbon double bonds; wherein the first functional monomer has first carbon-carbon double bonds and an epoxyethane group; and Step S200, performing polymerization of the carbon-carbon double bonds under an action of an initiator to obtain the biological valve material. In this disclosure, double bonds are introduced into the glutaraldehyde crosslinked biological valve material, and polymerization of the double bonds is further initiated, improving the stability of the glutaraldehyde crosslinked material and further reducing the risk of calcification caused by structural degradation.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
An injectable hydrogel for heart failure treatment with myocardial tissue repair function and its preparation method and use are disclosed. The hydrogel is prepared by chelating alginic acid and multivalent cations. The hydrogel is loaded with an active substance for repairing cardiac injury. The active substance is recombinant humanized collagen type III. The hydrogel is administrated into the left ventricle free wall by transendocardial injection. Implanting the hydrogel in the myocardium can increase the thickness of the left ventricular wall, adjust the stress of the ventricular wall, affect the morphology of the left ventricle, and prevent or reverse left ventricular enlargement. Further, the hydrogel is loaded with a new recombinant humanized collagen material that has the function of repairing cardiac tissue injury to further improve cardiac function and promote cardiac repair.
A deep learning-based MRI examination and diagnosis system for displacement of a temporomandibular joint disc includes: an acquisition unit, configured to acquire a human head MRI image; a labeling unit, configured to obtain temporomandibular joint area images based on the human head MRI image, and label the temporomandibular joint area images to obtain a training set, the temporomandibular joint area images being classified into images in which a joint disc is in normal and abnormal positions in open and closed states; and a diagnosis unit, configured to construct a first temporomandibular joint disc displacement diagnosis model, and train a first jaw joint disc displacement classification model based on the training set to obtain a second temporomandibular joint disc displacement diagnosis model which is configured to classify and recognize temporomandibular joint area images to be diagnosed, and output a temporomandibular joint disc displacement examination and diagnosis result.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
21.
METHOD FOR CALCULATING CARBON FOOTPRINT OF LEATHER CHEMICAL MATERIAL
Some embodiments of the disclosure provide methods for calculating carbon footprints of leather chemical materials. In some examples, the method includes: determining a calculation range of a carbon footprint of a leather chemical material in a life cycle as “cradle to gate”; determining a system boundary, a functional unit, and cut-off criteria for the carbon footprint of the leather chemical material in the life cycle; dividing the carbon footprint into a raw chemical obtaining process, a production process of the leather chemical material, and a waste disposal process within the system boundary; determining a carbon footprint calculation model for the leather chemical material according to resource consumption and environmental emission of each process; collecting and determining a quantity and a value required by each parameter in the carbon footprint calculation model; and calculating the carbon footprint of the leather chemical material using the carbon footprint calculation model.
A T1fr gene coding a type 1 fimbrial repressor (T1FR) protein, whose nucleotide sequence is shown in SEQ ID NO: 1. An amino acid sequence of the T1FR protein is shown in SEQ ID NO: 2. Applications of the T1FR protein in the inhibition of fimbrial growth, and intestinal colonization and pathogenicity of an adherent-invasive Escherichia coli (AIEC) strain are further provided.
C07K 14/47 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains provenant de vertébrés provenant de mammifères
Some embodiments of the disclosure provide accounting methods for carbon footprints of leather products. In some examples, the accounting method includes the following steps: firstly, determining a system boundary for a carbon footprint in a life cycle of a leather product; dividing the carbon footprint into a raw material production and transportation stage, a leather product production stage, and a leather product transportation and distribution stage within the system boundary for the leather product; determining carbon emission source inventories of the stages and emission factors thereof in combination with process and flow characteristics of the stages, and then constructing carbon emission accounting models of the stages, and calculating carbon footprint data of the stages, and, finally, obtaining the carbon footprint of the leather product.
CHINA GEZHOUBA GROUP MECHANICAL & ELECTRICAL CONSTRUCTION CO., LTD. (Chine)
SICHUAN UNIVERSITY (Chine)
XIHUA UNIVERSITY (Chine)
XI'AN JIAOTONG UNIVERSITY (Chine)
Inventeur(s)
Wei, Shuman
Wang, Ying
Wei, Yilei
Tong, Zheming
Zhou, Fuming
Chen, Qiang
Jiang, Qifeng
Abrégé
Disclosed in the present invention is a vertical-shiplift mounting and positioning method. The method comprises: designing a vertical-shiplift mounting and positioning reference network by means of a structure arrangement position of a shiplift; then, by means of the cooperation between a plurality of total stations and reference points, sequentially determining reference positioning points for the axis of an unobstructed section of a base plate of the shiplift, and mounting and positioning control points, wherein when point positions are determined, a step-wise manner is used, and previously determined point positions are used as reference points to determine subsequent point positions; and sequentially embedding positioning reference point apparatuses and positioning control point apparatuses during point position determination, and positioning and mounting racks and nut columns by means of the determined reference positioning points and the determined mounting and positioning control points. The method involves highly technical content, a simple operation and safety, is time-saving and labor-saving, and can achieve high-precision positioning for on-site mounting, thereby ensuring that the device mounting accuracy meets the high standards and requirements, improving the engineering quality, and ensuring the safe operation quality of vertical liftships.
A urinary system catheter is covered by an ethanol extract of propolis on a surface of the urinary system catheter. The EEP is used as a coating material of the urinary system catheter to prepare an antimicrobial urinary system catheter. The EEP serving as a surface coating can enhance surface hydrophilicity of the urinary system catheter, and clinical operation of the urinary system catheter is facilitated. Meanwhile, the EEP serving as the surface coating can prevent a bacterial biofilm from being formed on the surface of the urinary system catheter, thereby possessing antimicrobial and anti-infective effects, and a high anti-scab capacity. In addition, propolis is a natural substance, has the advantages of good biocompatibility and low cost, and is suitable for mass production. The urinary system catheter prepared by using the EEP as the coating has a good application prospect.
A sulfinate glycosyl donor of formula I and a method for preparing same as well as use thereof in preparing a glycoside compound including a thioglycoside compound and a carbon glycoside compound are provided. The sulfinate glycosyl donor has a special sulfinate structure. When the sulfinate glycosyl donor is used as a raw material to prepare the glycoside compound, an additional initiator does not need to be added, such that the production cost is saved, the generation of byproducts is reduced, and the glycoside compound with a purity greater than 98% is obtained. The sulfinate glycosyl donor can be used in the preparation of the glycoside compound such as the thioglycoside compound and the carbon glycoside compound.
C07H 5/10 - Composés contenant des radicaux saccharide dans lesquels les liaisons carbone-oxygène ont été remplacées par le même nombre de liaisons carbone-hétéro-atomes à des atomes d'halogènes, d'azote, de soufre, de sélénium ou de tellure au soufre, au sélénium ou au tellure au soufre
A protein capable of inhibiting type I fimbriae of Escherichia coli (E. coli) is identified, where the protein is named as Type I fimbrial repressor (TIFR) protein, and is encoded by a TIfr gene with an ID of GW576_23830. A method is further provided for inhibiting the growth of type I fimbriae of an E. coli strain, in which the TIfr gene is transformed into the strain.
An automatic detection function-integrated detection apparatus includes a drill rod and an elastic water storage bag; two sides of the drill rod are a head region and a tail region, respectively; an interior of the drill rod has a water supply channel, a side wall of the drill rod is provided with a first channel, and a first valve is disposed in the first channel. The automatic detection function-integrated detection apparatus and method for the water flowing fractured zone may complete the detection of the water flowing fractured zone while drilling, and thus the labor intensity of workers may be reduced.
E21B 21/08 - Commande ou surveillance de la pression ou de l'écoulement du fluide de forage, p. ex. remplissage automatique des trous de forage, commande automatique de la pression au fond
A method for the glycosylation modification of proteins and/or polypeptides uses glycosyl sulfinate as a raw material. The method for glycosylation and modification is applicable not only to proteins and/or peptides containing disulfide bonds, but also to proteins and/or peptides containing sulfhydryl groups. The method is even applicable to proteins and/or peptides containing both disulfide bonds and sulfhydryl groups.
In a method for preparing an aryl carbon glycoside compound including a gliflozin drug, a sulfinate glycosyl donor represented by formula W is used as a raw material to prepare the aryl carbon glycoside compound including the gliflozin drug. The method does not need to use an additional initiator.
In a method for preparing an aryl carbon glycoside compound including a gliflozin drug, a sulfinate glycosyl donor represented by formula W is used as a raw material to prepare the aryl carbon glycoside compound including the gliflozin drug. The method does not need to use an additional initiator.
A soot-suppression flame-separation combustion device for combustion calorimetry and in-situ free radicals monitoring is mainly composed of a premixed combustion gas guide tube, an inner flame generating seat, an oxidation flame separation guide, and a sample combustion chamber. The inner flame generating seat is arranged in the premixed combustion gas guide tube, the oxidation flame separation guide is arranged on the premixed combustion gas guide outlet end of the premixed combustion gas guide tube, the sample combustion chamber is a cavity arranged inside the oxidation flame separation guide, and the oxidation flame separation guide is evenly arranged with at least 4 oxidation flame separation guide paths in a manner of surrounding the sample combustion chamber. The combustion device utilizes the special structure of the oxidation flame separation guide to suppress the generation of smoke and limit the smoke particles to a specific combustion area.
F23D 14/56 - Buses pour étaler la flamme sur une surface, p. ex. pour le décapage de matériaux solides, le durcissement de surface ou le chauffage de pièces à travailler
F23D 14/02 - Brûleurs à gaz avec prémélangeurs, c.-à-d. dans lesquels le combustible gazeux est mélangé à l'air de combustion en amont de la zone de combustion
G01N 25/22 - Recherche ou analyse des matériaux par l'utilisation de moyens thermiques en recherchant la production de quantités de chaleur, c.-à-d. la calorimétrie, p. ex. en mesurant la chaleur spécifique, en mesurant la conductivité thermique sur l'oxydation par combustion ou par catalyse, p. ex. des constituants des mélanges gazeux
32.
Supramolecular hydrogel for lipophilic drug delivery, a preparation method therefor, and use thereof
2 are each independently selected from palmitoyl or oleoyl, respectively. The hydrogel can be used as a drug delivery system, and encapsulate and load various medicaments. In particular, it has good controlled-release for hydrophobic medicaments.
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
The present invention relates to dental medical instruments, and specifically discloses an automatic grinding drill device for oral caries, including a mounting frame. Two retainers are arranged on the mounting frame, the bottom of the mounting frame is connected with a support plate through drive assemblies, a drill bit assembly is arranged at the bottom of the support plate, and a visual recognition module is also arranged on the support plate. The present invention has the advantage that the retainers keep a real-time relative static state with teeth of a patient during use, needing no frequent correction, so that operation steps are simplified.
A61C 1/05 - Machines dentaires à forer ou couper caractérisées par l'entraînement des outils dentaires à commande par turbine
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
14B flaky nanocrystallines having an average grain size in a length direction of 70 nm to 800 nm and an average grain size in a thickness direction of 30 nm to 200 nm; and the second phase includes at least one selected from the group consisting of an M-Cu phase and an M-Cu—O phase, M being at least one selected from the group consisting of Ca and Mg.
H01F 1/057 - Alliages caractérisés par leur composition contenant des métaux des terres rares et des métaux de transition magnétiques, p. ex. SmCo5 et des éléments IIIa, p. ex. Nd2Fe14B
B22F 1/00 - Poudres métalliquesTraitement des poudres métalliques, p. ex. en vue de faciliter leur mise en œuvre ou d'améliorer leurs propriétés
B22F 3/16 - Compactage et frittage par des opérations successives ou répétées
B22F 3/20 - Fabrication de pièces ou d'objets à partir de poudres métalliques, caractérisée par le mode de compactage ou de frittageAppareils spécialement adaptés à cet effet par extrusion
B22F 9/00 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet
B22F 9/04 - Fabrication des poudres métalliques ou de leurs suspensionsAppareils ou dispositifs spécialement adaptés à cet effet par des procédés physiques à partir d'un matériau solide, p. ex. par broyage, meulage ou écrasement à la meule
C22C 24/00 - Alliages à base d'un métal alcalin ou alcalino-terreux
C22C 38/00 - Alliages ferreux, p. ex. aciers alliés
C22C 38/10 - Alliages ferreux, p. ex. aciers alliés contenant du cobalt
H01F 41/02 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateursAppareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour la fabrication de noyaux, bobines ou aimants
35.
BIOLOGICAL VALVE MATERIAL, AND PREPARATION METHOD THEREFOR AND USE THEREOF
A biological valve material and preparation method therefor and use thereof are provided. The preparation method includes step S100: chemically grafting first carbon-carbon double bonds with amino groups on the biological material, in which at least an aldehyde-based cross-linking is present; step S200: performing polymerization of carbon-carbon double bonds under an action of an initiator to obtain the biological valve material. This method forms more and larger polymer cross-linked networks through dual cross-linking, improving the cross-linking degree and anti-calcification performance of the biological valve material. While introducing carbon-carbon double bonds, additional functional groups are introduced to endow the biological valve material with new characteristics and further improve the performance.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
Disclosed is a drug for lowing blood glucose and/or improving diabetic complications, belonging to the technical field of biomedicine. According to the present disclosure, the drug for lowing blood glucose and/or improving diabetic complications is nanoparticles formed by a component containing lipoic acid and/or lipoic acid derivatives. The lipoic acid nanoparticles not only can control blood glucose safely and long-term, but also can realize the prevention/treatment of diabetic complications through lowering blood glucose and inhibiting oxidative stress. This drug has good clinical prospect.
The present invention belongs to the technical field of medicine, and in particular relates to an efficient and low-toxicity anti-cancer combined drug and a pharmaceutical composition. Provided is the use of a guanidine compound combined with piperlongumine in the preparation of an anti-cancer drug. The guanidine compound can be selected from metformin. Compared with a single drug, the combined drug has a better anti-cancer activity. Furthermore, compared with platinum-based chemotherapeutic drugs, the combined drug regimen has the same tumor killing efficacy, but has no significant effect on the body weight, immune system, liver function, kidney function, etc., of mice, indicating that the toxicity and side effects of the combined drug regimen are significantly weaker than those of the platinum-based chemotherapeutic drugs. Therefore, the combined drug scheme has good application prospects.
A method and system for strategically solving an innovative design problem are provided. A target analysis tool is determined according to a to-be-solved problem. An initial model is generated based on the target analysis tool. A target model is determined according to an interaction relationship among elements in the initial model and the target analysis tool. A problem characterization result of the target model is generated according to a preset interaction relationship. Retrieval information is generated according to the problem characterization result, based on which the retrieval is performed in a preset database to obtain target data. Different analysis tools can be used to analyze different to-be-solved problems. The retrieval is performed based on the problem characterization result to obtain the solution to the to-be-solved problem.
A rolling and sliding adaptive device for guiding and fixing a drill pipe includes a mounting platform, where the mounting platform is provided with a through hole for the drill pipe to pass through. Multiple rolling and sliding support mechanisms are arranged around the through hole. The rolling and sliding support mechanisms each include a support seat. The support seat is provided with a contact element telescopic and swingable on the support seat. A telescopic drive mechanism is provided between the contact element and the support seat. The contact elements on the multiple rolling and sliding support mechanisms form a funnel-shaped structure with a large upper part and a small lower part around the through hole. The rolling and sliding adaptive device is used on a deep in-situ high-fidelity coring calibration platform for accurate positioning of an assembly process of a multi-section drill pipe bin.
A method and system for multi-participant based conceptual design information modeling. The method includes the following steps. Initial design information generated by a plurality of design participants involved in different design stages during conceptual design of a target product is acquired. The initial design information is screened to obtain target design information in a target carrier form according to a carrier form corresponding to the initial design information. Subject information is extracted from the target design information. Based on a plurality of visualized forms under a plurality of dimensions, a plurality of visualized views of the subject information are generated under the plurality of dimension. A visualized view corresponding to a display authority of a design participant is displayed on the graphical user interface. The design participant can modify the design information based on the visualized view to obtain a target design information model.
G06F 30/12 - CAO géométrique caractérisée par des moyens d’entrée spécialement adaptés à la CAO, p. ex. interfaces utilisateur graphiques [UIG] spécialement adaptées à la CAO
G06F 111/02 - CAO dans un environnement de réseau, p. ex. CAO coopérative ou simulation distribuée
41.
COMPOUNDS AND USE THEREOF IN TREATMENT OF HDHODH-MEDIATED DISEASES
The present application belongs to the technical field of medicines, and particularly relates to compounds and the use thereof in treatment of hDHODH-mediated diseases. The novel small molecule compounds of the present application are shown as formula I, have outstanding hDHODH enzyme inhibitory activity and can be used for treating various hDHODH-mediated diseases, including but not limited to tumors, autoimmune diseases, virus infection and other diseases.
C07D 401/14 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant au moins trois hétérocycles
C07D 403/14 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 403/04 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 519/00 - Composés hétérocycliques contenant plusieurs systèmes de plusieurs hétérocycles déterminants condensés entre eux ou condensés avec un système carbocyclique commun non prévus dans les groupes ou
Disclosed are a corona-resistant N-grade insulation paper for a variable frequency motor and a preparation method thereof. The insulation paper has a sandwich structure, aramid nanofibers and mica nanosheets are taken as a sandwich material of the sandwich structure, aramid nanofibers and silicon carbide nanowires being taken as upper and lower surface layer materials, and three layers of materials are electrostatically sprayed and thermo-compressed to prepare the insulation paper. According to the present disclosure, by introducing mica sheets and the silicon carbide nanowires into the aramid nanofibers, the highly ordered arrangement inside the sandwich structure is realized through electrostatic spraying, which improves the temperature resistance and corona resistance of the insulation paper.
D21H 27/38 - Papier particulier non prévu ailleurs, p. ex. obtenu par des procédés multi-étapes à plusieurs jets au moins une des feuilles ayant une composition fibreuse différente de celle des autres feuilles
D21F 11/00 - Procédés de fabrication de longueurs continues de papier ou de carton, ou de nappe humide pour la production de panneaux de fibres, sur des machines à papier
Disclosed are a method for preparing an anisotropic flake nanocrystalline rare earth permanent magnet material and a rare earth permanent magnet material. In the disclosure, the method includes: step 1, preparation of a precursor flake nanocrystal magnetic powder, where a number of grains of flake nanocrystals inside the precursor flake nanocrystalline magnetic powder accounts for not less than 85% of a total number of grains inside the precursor flake nanocrystalline magnetic powder; step 2, orientation treatment by hot deformation: subjecting the precursor flake nanocrystalline magnetic powder or a green body prepared from the precursor flake nanocrystalline magnetic powder to the hot deformation, such that flake nanocrystals are regularly arranged; and step 3, post-processing for optimizing orientation.
H01F 41/02 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateursAppareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour la fabrication de noyaux, bobines ou aimants
B22F 3/24 - Traitement ultérieur des pièces ou objets
C22C 38/00 - Alliages ferreux, p. ex. aciers alliés
H01F 1/057 - Alliages caractérisés par leur composition contenant des métaux des terres rares et des métaux de transition magnétiques, p. ex. SmCo5 et des éléments IIIa, p. ex. Nd2Fe14B
44.
MULTIPLE MIXED SAMPLE DIRECT RNA NANOPORE SEQUENCING METHOD AND SYSTEM
The invention relates to the field of sequencing, and particularly to a multiple mixed sample direct RNA nanopore sequencing method and system. The method relates to sequencing n types of test sample RNA polynucleotides (2≤n≤24, and n being an integer), and comprises: performing nanopore sequencing on sequencing structures corresponding to the n test sample RNA polynucleotides, and extracting corresponding electric-current signal data; segmenting the electric-current signal data of a barcode sequence therein, invoking a classification model to perform analysis, obtaining sequence information of the barcode sequence, and further obtaining classification information of the n test sample RNA polynucleotides; wherein a barcode sequence is specific to each test sample RNA polynucleotide, and the barcode sequence is selected from any one of SEQ ID NOs: 1-24. The provided method and system allow for simultaneously sequencing a plurality of biological samples on a single chip, thereby reducing the number of initially inputted biological samples and reducing the cost of multi-sample sequencing.
C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p. ex. séquençage par hybridation [SBH]
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
The present invention relates to the field of chemical medicines. Disclosed are a 1H-pyrrole-2-amide derivative and a use thereof. In order to obtain a specific inhibitor for an m6A-modified RNA reader protein YTHDC1 of AML, the present invention provides a 1H-pyrrole-2-amide derivative as shown in formula I, wherein said derivative has high inhibitory activity against YTHDC1. In-vitro experiments prove that said derivative can effectively inhibit the proliferation of acute myeloid leukemia cells, significantly arrest a cell cycle of the acute myeloid leukemia cells in the G0/G1 phase, and induce differentiation and apoptosis of the acute myeloid leukemia cells. A compound and a salt thereof or a pharmaceutical composition of the 1H-pyrrole-2-amide derivative of the present invention provide new options for anti-tumor drug development targeting YTHDC1 in the art, and have good application prospects.
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 207/416 - Pyrrolidines-2, 5 diones avec des hétéro-atomes ou des atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux autres atomes de carbone du cycle
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 409/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 413/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/12 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 417/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre et d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant au moins trois hétérocycles
C07D 413/14 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes d'azote et d'oxygène comme uniques hétéro-atomes du cycle contenant au moins trois hétérocycles
A61K 31/4439 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'azote comme hétéro-atome du cycle, p. ex. oméprazole
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/4025 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil non condensés et contenant d'autres hétérocycles, p. ex. cromakalim
A61K 31/4178 - 1,3-Diazoles non condensés et contenant d'autres hétérocycles, p. ex. pilocarpine, nitrofurantoïne
A61K 31/422 - Oxazoles non condensés et contenant d'autres hétérocycles
A61K 31/427 - Thiazoles non condensés et contenant d'autres hétérocycles
A61K 31/4155 - 1,2-Diazoles non condensés et contenant d'autres hétérocycles
A61K 31/4353 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/519 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime condensées en ortho ou en péri avec des hétérocycles
A61K 31/5383 - 1,4-Oxazines, p. ex. morpholine condensées en ortho ou en péri avec des systèmes hétérocycliques
A61K 31/506 - PyrimidinesPyrimidines hydrogénées, p. ex. triméthoprime non condensées et contenant d'autres hétérocycles
A61K 31/4525 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à cinq chaînons avec l'oxygène comme hétéro-atome du cycle
A61K 31/445 - Pipéridines non condensées, p. ex. pipérocaïne
A61K 31/5386 - 1,4-Oxazines, p. ex. morpholine condensées en spiro ou formant une partie de systèmes cycliques pontés
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A composite insulating material based on dielectrophoretic force orientation and its preparation method are provided. The method includes: S1, preparing dielectric composite microspheres with a dielectric epoxy resin as a core and a hexagonal boron nitride sheet as a shell; S2, dispersing the hexagonal boron nitride sheet and the dielectric composite microspheres in an organic solvent to obtain a dispersion liquid, and adding an epoxy resin, an epoxy resin curing agent, and an epoxy resin accelerator to the dispersing liquid, and evaporating the organic solvent to obtain a composite substrate; S3, pouring the composite substrate into a container, wherein an upper surface and a lower surface of the container are connected with electrodes, respectively, transferring the container to a vacuum oven, and connecting a power supply of the container to adjust a voltage amplitude and a frequency of the electrodes, conducting dielectrophoretic force orientation on the dielectric composite microspheres in the composite substrate, so as to cause the dielectric composite microspheres to arrange along a direction of electric field; S4, increasing a temperature of the container to cure the composite substrate, cutting off the power supply to the container after curing, and obtaining the composite insulating material.
C09C 3/00 - Traitement, en général, de substances inorganiques, autres que des charges fibreuses, pour améliorer leurs propriétés de pigmentation ou de charge
47.
Bifunctional and flexible hydrogel optical fiber, preparation method and application thereof
Synechococcus cells, PEGDA, gelatin methacrylate (GelMA), anhydrous strontium chloride and DMPA; and raw materials of a cladding include PEGDA, methacrylamide, sodium alginate and DMPA. A continuous and controllable direct oxygen supply function is provided through an optical fiber structure.
G02B 1/04 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de substances organiques, p. ex. plastiques
The present invention provides a modified cross-linked polyethylene and a preparation method therefor, and a recycled product and a preparation method therefor. The preparation method for the modified cross-linked polyethylene includes: milling waste cross-linked polyethylene by using a solid-phase force chemical reactor, and then using asphalt as a plasticizer for plasticization to obtain the modified cross-linked polyethylene. The plasticization treatment enables the decross-linked waste cross-linked polyethylene/asphalt material obtained after milling to have excellent processing fluidity, and thus, the decross-linked waste cross-linked polyethylene/asphalt material is suitable for preparing high-performance recycled products in various thermoplastic processing processes. The waste ultrafine cross-linked polyethylene powder subjected to asphalt plasticization can be formed in a compressive force field having a high pressure, and can also be suitable for thermoplastic extrusion processing of a low shear force field. The prepared recycled product has good mechanical properties.
C08L 23/26 - Compositions contenant des homopolymères ou des copolymères d'hydrocarbures aliphatiques non saturés ne possédant qu'une seule liaison double carbone-carboneCompositions contenant des dérivés de tels polymères modifiées par post-traitement chimique
B29B 7/42 - MélangeMalaxage continu, avec dispositifs mécaniques de mélange ou de malaxage avec dispositifs de mélange ou de malaxage mobiles rotatifs avec un seul arbre à vis ou à vis sans fin
B29B 7/46 - MélangeMalaxage continu, avec dispositifs mécaniques de mélange ou de malaxage avec dispositifs de mélange ou de malaxage mobiles rotatifs avec plus d'un arbre
Disclosed is a system and a method for monitoring and adjusting a harmonic emission level of an industrial load. The method may include obtaining a grid load for a current time period, and determining, for each of at least one type of industrial load, a generalized probabilistic model for the industrial load by obtaining harmonic monitoring data of the industrial load at a preset frequency, determining a harmonic characteristic dataset for the industrial load, constructing an initial generalized probabilistic model for target harmonic data, and obtaining the generalized probabilistic model for the target harmonic data. The method may further include determining a harmonic impact factor of the industrial load, and in response to determining that the harmonic impact factor of the industrial load satisfies a first preset condition, generating and sending an adjustment instruction to a control device to adjust the at least one type of industrial load.
H02J 13/00 - Circuits pour pourvoir à l'indication à distance des conditions d'un réseau, p. ex. un enregistrement instantané des conditions d'ouverture ou de fermeture de chaque sectionneur du réseauCircuits pour pourvoir à la commande à distance des moyens de commutation dans un réseau de distribution d'énergie, p. ex. mise en ou hors circuit de consommateurs de courant par l'utilisation de signaux d'impulsion codés transmis par le réseau
G06F 17/18 - Opérations mathématiques complexes pour l'évaluation de données statistiques
50.
Coupling numerical simulation method for site selection of underground salt cavern hydrogen storage
The disclosure relates to the field of underground salt cavern energy storage, and discloses a coupling numerical simulation method for site selection of an underground salt cavern hydrogen storage, which specifically comprises the following. Geological data of an area where the salt cavern hydrogen storage is to be established is obtained. A three-dimensional model is established and grid meshing is performed. An initial coupling field is established and balanced based on the geological model, and then excavation simulation of the salt cavern hydrogen storage is performed. A geological model after excavation and related parameter values thereof are imported into TOUGH2MP software, a stress model in FLAC3D software is coupled with hydraulic and thermal models in the TOUGH2MP software to simulate a stress, hydraulic, and thermal coupling behavior process of rock layers around the salt cavern hydrogen storage in the area, and a coupled simulation result is obtained.
G06F 30/23 - Optimisation, vérification ou simulation de l’objet conçu utilisant les méthodes des éléments finis [MEF] ou les méthodes à différences finies [MDF]
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
21421414B flaky nanocrystals in the length direction is 70-800 nm, and the average grain size thereof in the thickness direction is 30-200 nm; and the second phase comprises at least one of an M-Cu phase and an M-Cu-O phase, wherein M is at least one of Ca and Mg. In the present invention, a rare earth oxide at an RE-Fe-B magnetic powder interface is reduced by using Ca and/or Mg in an M-Cu alloy, such that the distribution of the rare earth-rich phase can be improved, and the grains of the main-phase nanocrystals can be refined; in addition, the second phase distributed at the magnetic powder interface inhibits the formation of coarse grains at the magnetic powder interface, such that the microstructure of the magnet is optimized, and the coercive force is improved.
H01F 1/057 - Alliages caractérisés par leur composition contenant des métaux des terres rares et des métaux de transition magnétiques, p. ex. SmCo5 et des éléments IIIa, p. ex. Nd2Fe14B
52.
Thermochromic silicone rubber composite heat dissipation pad and preparation method thereof
A silicone rubber composite heat dissipation pad and a preparation method thereof are provided. The method includes: dispersing hydroxyl-functionalized boron nitride nanosheet powder into deionized water, pouring it into a specialized container, pre-freezing it using liquid nitrogen, and then freeze-drying it to obtain a boron nitride nanosheet skeleton arranged in a horizontal direction; uniformly dispersing thermochromic nanoparticles in acetone to obtain a dispersion, mixing the dispersion with liquid silicone rubber and stirring until acetone is completely evaporated, then adding a curing agent to obtain a liquid silicone rubber pre-cure solution; pouring the liquid silicone rubber pre-cure solution into a container containing the boron nitride nanosheet skeleton, so that the liquid silicone rubber pre-cure solution is fully immersed in an interior of the boron nitride nanosheet skeleton; and then curing is carried out by elevating the temperature to obtain the heat dissipation pad.
C08K 9/02 - Ingrédients traités par des substances inorganiques
C08K 9/04 - Ingrédients traités par des substances organiques
C09C 3/00 - Traitement, en général, de substances inorganiques, autres que des charges fibreuses, pour améliorer leurs propriétés de pigmentation ou de charge
C09C 3/04 - Traitement physique, p. ex. broyage, traitement par des vibrations ultrasoniques
C09C 3/08 - Traitement par des composés organiques de bas poids moléculaire
C09K 9/00 - Substances devenant sombres, c.-à-d. substances pour lesquelles la gamme de longueurs d'onde absorbées est modifiée par excitation avec une énergie sous une forme quelconque
A chrome-free tanning process of an ecological leather is characterized by a TWS+sodium lignosulfonate+TWLZ ternary tanning process system. The sodium lignosulfonate added can not only have a fixation effect on a TWS tanning agent to make the TWS tanning not undergo detanning at a low pH, but also significantly improve the uniformity of distribution of a TWLZ tanning agent in a hide/skin and promote the formation of a stable cross-linked network structure by the TWLZ tanning agent in a collagen fiber, which effectively overcomes the defects of tanning performance of the existing tanning systems to obtain a leather with uniform and sufficient tanning, a high isoelectric point, a strong electropositivity, excellent absorption for post-tanning chemicals, and a prominent softness, and gives a leather a wide use range and a high quality.
An assembly method for a deep in-situ high-fidelity coring calibration platform includes the following steps: S1: fixing a core bin assembly subsystem on a preset ground foundation and fixing a simulator of a core bin on a mounting base plate of the core bin assembly subsystem; S2: driving a cylinder and driving the mounting base plate to move to a preset position; S3: driving a servo motor and controlling two clips to move close to each other; S4: fixing a drill pipe bin assembly subsystem on the ground foundation; S5: assembling multiple sections of a drill pipe bin in turn; aligning and connecting a bottom of the drill pipe bin to the simulator, and aligning and communicating the top of the drill pipe bin with the lower part of an adaptive drill pipe guide structure; and S6: driving the adaptive drill pipe guide structure to perform accurate positioning.
B23P 19/04 - Machines effectuant simplement l'assemblage ou la séparation de pièces ou d'objets métalliques entre eux ou des pièces métalliques avec des pièces non métalliques, que cela entraîne ou non une certaine déformationOutils ou dispositifs à cet effet dans la mesure où ils ne sont pas prévus dans d'autres classes pour assembler ou séparer des pièces
B23P 19/10 - Alignement de pièces qui doivent être assemblées entre elles
E21B 41/00 - Matériel ou accessoires non couverts par les groupes
G01M 99/00 - Matière non prévue dans les autres groupes de la présente sous-classe
E21B 25/00 - Appareils pour recueillir ou retirer des carottes intactes, p. ex. tubes carottiers ou extracteurs de carottes
55.
Real-time temperature-pressure detection and rapid processing system for calibration platform
A real-time temperature-pressure detection and rapid processing system for a calibration platform, comprises an inner return pipe, and a water supply pipe is provided therein with an inner water supply pipe. An outer wall of the inner water supply pipe is connected with an inner wall of the water supply pipe through multiple springs. An outer wall of the inner return pipe is connected with an inner wall of a return pipe through multiple springs. The return pipe and the water supply pipe are made of a thermosetting polymer material. The multiple springs, the inner water supply pipe, and the inner return pipe are covered with a heat conducting material. The system further includes a temperature-pressure detection assembly. The assembly includes multiple infrared sensors arranged at two sides of the return pipe and the water supply pipe, a booster pump, a heater, and infrared sensors connected with a control unit.
The present invention provides a use of aescin and/or an aescin salt compound as an adjuvant in a vaccine. The results of animal experiments show that the combination of aescin and an antigen can increase the antibody levels of sera IgG, IgG1, and IgG2a, i.e., enhance both humoral and cellular immune responses, and can be used as an adjuvant in a vaccine.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
The present application relates to the technical field of biomedicine, and provides a use of a transfection complex containing aescin and/or a salt compound thereof in transfection promotion. The present application provides a transfection complex containing an aescin compound (aescin and/or an aescin salt compound). The complex is used for delivering a nucleic acid to improve the transfection efficiency, and the delivered nucleic acid comprises deoxyribonucleic acid (DNA) and/or ribonucleic acid (RNA). The present application further discloses that the transfection complex in which the aescin compound is used in combination with other non-viral vectors is used for transfection. In the present application, it is found for the first time that aescin and/or the aescin salt compound in transfection can effectively improve the transfection capability of a carrier and can be used in nucleic acid drugs.
A61K 47/28 - Stéroïdes, p. ex. cholestérol, acides biliaires ou acide glycyrrhétinique
A61K 31/711 - Acides désoxyribonucléiques naturels, c.-à-d. contenant uniquement des 2'-désoxyriboses liés à l'adénine, la guanine, la cytosine ou la thymine et ayant des liaisons 3'-5' phosphodiester
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
A61K 31/713 - Acides nucléiques ou oligonucléotides à structure en double-hélice
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
The present disclosure provides a method for improving a biological nitrogen removal effect of low-temperature sewage, and relates to the technical field of sewage treatment. In the present disclosure, the method is implemented by adding an exogenous signal molecule. The exogenous signal molecule can intervene in a quorum sensing (QS) phenomenon among microorganisms, and can also reduce mixed liquor suspended solids (MLSS), reduce an amount of remaining sludge, and reduce a cost of sludge treatment while effectively improving the low-temperature nitrogen removal effect.
Disclosed is a system and a method for controlling a multi-stage voltage sag. The system includes a power quality monitoring device with a processor, a voltage sag analysis device, a voltage sag data storage device, and an early warning device. The power quality monitoring device is configured to read voltage sag data and fault clearing information and send the voltage sag data to a power terminal device. The voltage sag analysis device is configured to determine a cause of the multi-stage voltage sag at different grid locations; determine an updated value of a fault clearing time of a relay protection device and retrofit location information of an electric power stabilizing device; control a corresponding relay protection device to adjust a count of capacitors and types of the capacitors to be connected to a circuit; and issue an early warning notification of retrofitting the electric power stabilizing device to a user.
H02J 13/00 - Circuits pour pourvoir à l'indication à distance des conditions d'un réseau, p. ex. un enregistrement instantané des conditions d'ouverture ou de fermeture de chaque sectionneur du réseauCircuits pour pourvoir à la commande à distance des moyens de commutation dans un réseau de distribution d'énergie, p. ex. mise en ou hors circuit de consommateurs de courant par l'utilisation de signaux d'impulsion codés transmis par le réseau
A high-temperature superconducting flux pump system comprises a flux pump body, a superconducting load, and a stator group. A double-pancake coil group comprises at least one double-pancake coil. The stator group comprises at least one stator. The flux pump body has an air gap for receiving the stator group. The superconducting load and the stator group are connected to form a closed circuit. The high-temperature superconducting flux pump system has a simpler structure, solves the problem of low charging rate of magnets, and greatly reduces the power cost without changing the magnet structure and winding cost.
Disclosed is a preparation method of a plant biomass-based active tanning agent. Under a low-temperature reaction condition, cyanuric chloride and a plant biomass compound are used to synthesize an environment-friendly plant biomass-based active tanning agent through a nucleophilic substitution reaction. The active tanning agent obtained in the present disclosure appears as a white or light brown emulsion at room temperature, and has substantial active groups such as hydroxyl groups, carboxyl groups and ester groups introduced into its structure, thus endowing leathers with desirable hydrothermal stability and physical properties and having a desirable synergistic effect with metal tanning agents. Meanwhile, health and environment risks caused by hexavalent chromium and free formaldehyde in leathers are avoided.
The present invention relates to the field of chemical medicines, and provides a novel heterocyclic compound, a preparation method therefor, and a use thereof. The structure of the heterocyclic compound is as shown in formula (I). The compound provided in the present invention can effectively inhibit the proliferation of squamous cell carcinoma, and provides a new choice for preparing drugs for preventing and/or treating squamous cell carcinoma.
The present invention belongs to the field of chemical drugs, and provides a 5-fluorouracil derivative and an anti-tumor use thereof. The structure of the 5-fluorouracil derivative is represented by formula (I). The compound provided by the present invention can effectively inhibit the proliferation of squamous cell carcinoma. Moreover, the inhibitory effect of compound (3a) is significantly better than that of 5-fluorouracil. The present invention provides a new option for preparing drugs for preventing and/or treating squamous cell carcinoma.
C07D 239/553 - Deux atomes d'oxygène liés par une liaison double ou sous forme de radicaux hydroxyle non substitués avec d'autres hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, liés directement aux atomes de carbone du cycle avec des atomes d'halogène ou avec des radicaux nitro liés directement aux atomes de carbone du cycle, p. ex. fluoro-uracile
The present invention belongs to the field of animal gas anesthesia, and provides a quantitative and precise gas anesthesia method and device for experimental animals. The quantitative and precise gas anesthesia device for experimental animals includes an anesthetic fluid tank, a drainage tube, catheters, closed animal anesthetic tanks, and a recycling container, where anesthetic fluid is put into the anesthetic fluid tank, the bottom of the anesthetic fluid tank is connected to an inlet of the drainage tube, a set of holes are evenly arranged in the drainage tube, each hole is connected to an inlet of each catheter, and outlets of the catheters extend into the closed animal anesthetic tanks.
The present disclosure relates to a liquid-cooling radiating pipe and a vacuum interrupter with a built-in liquid-cooling radiating pipe, belonging to the field of vacuum circuit breakers. Based on an original structure of an vacuum interrupter, a liquid-cooling radiating pipe of a Tesla valve structure is arranged in a conductive rod of the vacuum interrupter with the built-in liquid-cooling radiating pipe, and liquid metal is used as a circulating coolant in the liquid-cooling radiating pipe, and by using the self-circulating flow of the liquid metal in the pipeline, the capacity of the conductive rod to dissipate heat to the outside is significantly increased, and the problem of excessive internal temperature rise of a vacuum circuit breaker is effectively solved.
The present invention relates to a transdermal photocuring forming hydrogel with biological activity. The hydrogel can release recombinant collagen with biological activity, the recombinant collagen includes a sequence as shown in SEQ ID No. 1, an amino acid sequence of the recombinant collagen includes N basic repetitive units, and each basic repetitive unit includes n1 of the following characteristic amino acid sequences: “G-Xaa1-Xaa2-G-E-Xaa3”; the 3′ end and the 5′ end of the basic repetitive unit are connected to form the above characteristic amino acid sequence. The recombinant collagen provided by the present invention has relatively obvious integrin binding activity, and has the effects of promoting cell adhesion, proliferation and differentiation. The hydrogel of the present invention has good biocompatibility and stable quality, which can be cured and formed in situ in a transdermal photo-crosslinking manner after injection, with simple, convenient and controllable operation.
The present invention relates to the field of polymer synthesis, and relates to a high-whiteness and low-impurity-content polyarylether and a preparation method therefor. The present invention provides a preparation method for high-whiteness and low-impurity-content polyarylether. The preparation method comprises the following steps: 1) performing a dehydration reaction; 2) first-time solvent recycling; 3) performing solvent recycling and resin purification by means of an extraction method; 4) performing auxiliary agent recycling, resin washing, and washing water purification; and 5) electrolyzing sodium chloride. Compared with traditional processes, the method of the present invention can greatly improve the purity and whiteness of obtained resin, the whiteness being greater than or equal to 85, and the impurity content (comprising volatile matter and ash content) being less than or equal to 12 ppm, and is more conducive to product purification and adaptation to subsequent application requirements in high-end fields; and as high-grade resin, the invention fills a gap domestically and is used for preparing high-quality workpieces such as special thermoplastic composite materials for large aircrafts and special materials for radars and stealth aircraft parts, achieving the effects of reducing costs and improving efficiency.
xyz100-x-y-z100-x-y-z, wherein x, y and z respectively represent the atomic numbers of V, Ti, Fe and M, with the value of x being in the range of 60-85, the value of y being in the range of 10-20, and the value of z being in the range of 0-6; and M is one or more of Cr, Mn, Al, and RE, with RE being a rare-earth metal. In a vanadium-based hydrogen storage alloy prepared from a high-vanadium iron alloy, the vanadium content can be controlled to be 60-85 mol%, such that the vanadium-based hydrogen storage alloy has good cycling stability, the attenuation of the hydrogen release amount in the first 10 hydrogen absorption and desorption cycles is only less than or equal to 3%, thereby overcoming the problem of the attenuation being overly fast during the initial stage of the hydrogen absorption and desorption cycles in a low-vanadium alloy (the vanadium content being less than 60 mol%), and greatly reducing the processing cost of the high-vanadium solid solution type hydrogen storage alloy.
Disclosed are a preparation method for a flaky anisotropic nanocrystalline rare earth permanent magnet material, and a rare earth permanent magnet material. The preparation method of the present invention comprises: S1. Preparing precursor flaky nanocrystalline magnetic powder: the proportion of crystal grains of flaky nanocrystal in the prepared precursor flaky nanocrystalline magnetic powder being 85% or above; S2. Thermal deformation machining orientation processing: performing thermal deformation machining on the precursor flaky nanocrystalline magnetic powder or on a blank prepared from the precursor flaky nanocrystalline magnetic powder, giving the flaky nanocrystals a regular arrangement; S3. Orientation optimization post-processing. The preparation method provided in the present invention involves performing thermal deformation machining on a precursor flaky nanocrystalline magnetic powder, the orientation of the poles of the flaky nanocrystals being easy to rotate during the thermal deformation machining process, performing orientation optimization post-processing, and obtaining an anisotropic rare earth permanent magnet material having excellent magnetic properties. The process is simple, easy to control, has high production efficiency, and is suited to industrial batch production.
H01F 1/057 - Alliages caractérisés par leur composition contenant des métaux des terres rares et des métaux de transition magnétiques, p. ex. SmCo5 et des éléments IIIa, p. ex. Nd2Fe14B
70.
BIOLOGICAL VALVE MATERIAL BASED ON ALDEHYDE GROUP CROSSLINKING, PREPARATION METHOD THEREFOR, AND USE THEREOF
A biological valve material based on aldehyde group crosslinking, a preparation method therefor, and use thereof. The preparation method comprises: step S110, contacting a biological material with an aldehyde group crosslinking agent solution for crosslinking; step S120, soaking the biological material treated by step S110 in a solution containing a first functional monomer, and carrying out a reaction to introduce a first carbon-carbon double bond, wherein the first functional monomer has the first carbon-carbon double bond and an oxiranyl group; step S130, soaking the biological material treated by step S120 in a solution containing a second functional monomer, wherein the second functional monomer has a second carbon-carbon double bond; and step S200, carrying out a polymerization reaction of the carbon-carbon double bonds under the action of an initiator to obtain the biological valve material. The method yields more larger polymer crosslinking networks by means of two rounds of crosslinking, thus increasing the degree of crosslinking of the biological material and improving anti-calcification performance.
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
C08F 220/32 - Esters contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle contenant des radicaux époxyde
71.
METHOD FOR PREPARING BIOLOGICAL VALVE MATERIAL BY COPOLYMERIZATION AND CROSSLINKING, BIOLOGICAL VALVE MATERIAL, AND USE
A method for preparing a biological valve material by copolymerization and crosslinking, a biological valve material, and use. The preparation method comprises: step S110, contacting a biological material with an aldehyde group crosslinking agent solution for crosslinking; step S120, soaking the biological material treated by step S110 in a solution containing a first functional monomer, and carrying out a chemical reaction to introduce a first carbon-carbon double bond, wherein the first functional monomer has the first carbon-carbon double bond and an oxiranyl group; step S130, soaking the biological material treated by step S120 in a solution containing a second functional monomer, wherein the second functional monomer has a second carbon-carbon double bond and a functional group B; step S200, carrying out a polymerization reaction of the carbon-carbon double bonds under the action of an initiator to obtain the biological valve material. According to the method, an additional functional group is introduced while the second carbon-carbon double bond is introduced, so that the biological material can be endowed with new properties.
METHOD FOR PREPARING BIOLOGICAL VALVE MATERIAL BY MEANS OF DOUBLE-BOND POLYMERIZATION AFTER ALDEHYDE CROSSLINKING, AS WELL AS BIOLOGICAL VALVE MATERIAL AND USE
Provided are a method for preparing a biological valve material by means of double-bond polymerization after aldehyde crosslinking, as well as the biological valve material and use. The preparation method comprises: step S110, contacting a biological material with an aldehyde crosslinking agent solution for crosslinking; step S120, soaking the biological material treated in step S110 in a solution containing a first functional monomer, and linking a first carbon-carbon double bond in the reaction, wherein the first functional monomer has the first carbon-carbon double bond and an oxirane group; and step S200, under the action of an initiator, carrying out a polymerization reaction on carbon-carbon double bonds to obtain the biological valve material. After the double bonds are introduced into the glutaraldehyde-crosslinked biological valve material, polymerization of the double bonds is further initiated, such that the stability of the glutaraldehyde-crosslinked material is improved, and a calcification risk caused by structural degradation is further lowered, thereby having certain anti-calcification capacity.
Disclosed is use of SlPIF4 as a negative regulatory factor in the improvement of melatonin content of tomato fruits. The content of melatonin in the tomato fruits is reduced by means of the overexpression of an SlPIF4 gene driven by a constitutive promoter 35S in tomatoes, and the increase in melatonin content in interfered and knocked-out strains indicates that the SlPIF4 as the negative regulatory factor inhibits the synthesis of melatonin; therefore, the melatonin synthesis can be significantly improved by interfering and knocking out the SlPIF4 gene, and the present invention can be applied to synthetic biology research and genetic breeding quality improvement of tomato melatonin.
A shear testing system and method of thermo-seepage-mechanical field and engineering disturbance coupling under deep and complex condition are provided. The shear testing system can be used in conjunction with an axial pressure application device to simplify the structure, save costs, and facilitate a triaxial confining pressure—temperature—axial pressure—torsional shear coupled test on a rock specimen. The shear testing system can achieve the following three purposes. First, the shear testing system can convert an axial pressure into a torsional shear force through a transmission mechanism of a power conversion assembly. Second, the shear testing system can apply an axial pressure to the rock specimen fixed between two specimen fixing heads, through a pressure shaft of an axial pressure mechanism. Third, the shear testing system can apply a triaxial confining pressure and a temperature field to the rock specimen.
G01N 3/24 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique en appliquant des efforts permanents de cisaillement
G01N 3/16 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression appliqués par un mécanisme
121231231233 may connected to an adjacent group to form a ring. The organic compound exhibits good light-emitting performance, and is therefore applicable to organic electroluminescent devices, improving device performance.
An ultra-thin high-strength proton exchange membrane, and a preparation method therefor and the use thereof. The ultra-thin high-strength proton exchange membrane is a membrane obtained by uniformly coating a Nafion dispersion on the surface of an ultra-thin polyethylene film having an ultra-high molecular weight. The ultra-thin high-strength proton exchange membrane has both high strength and good proton exchange performance, and has a very small internal resistance and a tensile strength up to 80 MPa.
The present invention relates to the technical field of waterborne synthetic leather manufacture, and specifically, provides a novel Pickering foam templating-based method for preparing a waterborne polyurethane (WPU) synthetic leather foaming layer. The method provided comprises: mixing a WPU emulsion and a waterborne cross-linking agent to obtain mixed WPU slurry; mixing the mixed WPU slurry and hydrophobic solid particles, and then emulsifying and dispersing the mixture to obtain Pickering water-based foam slurry; and drying the Pickering water-based foam slurry to obtain the WPU synthetic leather foaming layer. According to the preparation method provided by the present invention, polyurethane latex particles and the hydrophobic solid particles are jointly adsorbed and dried on a water-gas interface to form a double-layer solid particle film having a Janus structure, so that the obtained Pickering foam has high stability in the drying process, uniform cells, good hand feeling, good mechanical properties, and good sanitary performance.
C08J 9/28 - Mise en œuvre de substances macromoléculaires pour produire des matériaux ou objets poreux ou alvéolairesLeur post-traitement par élimination d'une phase liquide d'un objet ou d'une composition macromoléculaire, p. ex. par séchage du coagulum
D06N 3/14 - Cuir artificiel, toile cirée ou matériau similaire obtenu par enduction de nappes fibreuses avec une substance macromoléculaire, p. ex. avec des résines, du caoutchouc ou leurs dérivés avec des composés macromoléculaires obtenus autrement que par des réactions faisant intervenir uniquement des liaisons non saturées carbone-carbone avec des polyuréthanes
C08L 5/08 - ChitineSulfate de chondroïtineAcide hyaluroniqueLeurs dérivés
78.
STRUCTURE AND METHOD FOR EXCITATION ACROSS DEWAR WALL, AND MAGNETICALLY CONDUCTIVE MIDDLEWARE
The present invention relates to the technical field of superconducting excitation, and in particular to a structure and method for excitation across a Dewar wall, and a magnetically conductive middleware. The structure for excitation across a Dewar wall comprises a flux pump, a superconducting stator, a magnetic yoke and a superconducting load. The flux pump is arranged outside a Dewar. The superconducting stator the superconducting load are connected to each other so as to form a closed loop, and are arranged in the Dewar along with the magnetic yoke. The magnetic yoke and the flux pump are closely adjacent to the same Dewar wall area, and the superconducting stator is located in an air gap between the magnetic yoke and the flux pump. The magnetically conductive middleware comprises a carrier and a magnetically conductive element embedded in the carrier, the carrier being made of a non-ferromagnetic material. The method for excitation across a Dewar wall comprises: generating an alternating traveling wave magnetic field by means of a flux pump arranged outside a Dewar; the alternating traveling wave magnetic field being transmitted into the Dewar; and exciting a superconducting stator by means of the alternating traveling wave magnetic field. In the present invention, the flux pump is arranged outside the cryogenic vacuum Dewar, such that the flux pump has more heat dissipation mode options, and the size limit of the flux pump can also be ameliorated.
The present invention provides a transdermal photocuring forming hydrogel with biological activity, and a preparation method therefor and use thereof. The hydrogel can release a recombinant collagen with biological activity. The recombinant collagen comprises a sequence set forth in SEQ ID No. 1. An amino acid sequence of the recombinant collagen comprises N basic repeating units. Each of the basic repeating units comprises n1 characteristic amino acid sequences as follows: "G-Xaa1-Xaa2-G-E-Xaa3"; the 3' end and the 5' end of the basic repeating unit are connected to form the described characteristic amino acid sequence. The recombinant collagen has relatively significant integrin binding activity and has the effects of promoting cell adhesion, proliferation, and differentiation. The hydrogel has good biocompatibility and stable quality, can be cured and formed in situ in a transdermal photo-crosslinking mode after injection, is simple and controllable to operate, and meets the clinical filling requirement for irregular defects, thereby achieving a better soft tissue filling effect.
The present invention discloses a recombinant collagen protein and its use in the cartilage repair matrix. The present invention discloses a recombinant collagen protein which contains the sequence shown in SEQ ID No. 1; the amino acid sequence of the stated recombinant collagen protein comprises N basic repetitive units; the basic repetitive unit contains n1 amino acid sequences with the following characteristic: G-Xaa1-Xaa2-G-E-Xaa3; the 3′ end and the 5′ end of the basic repetitive unit are connected to form the amino acid sequence with the above characteristic. The recombinant collagen protein claimed by the present invention has significant integrin binding activity, has the effect of promoting cell adhesion, proliferation, differentiation, and repairing cartilage tissue defects, etc, and it has promising prospects for application.
A recombinant collagen and the use thereof in cartilage repair matrix. The recombinant collagen comprises a sequence as shown in SEQ ID No.1; the amino acid sequence of the recombinant collagen comprises N basic repeating units, and the basic repeating units contain N1 characteristic amino acid sequences as follows: "G-Xaa1-Xaa2-G-E-Xaa3"; and the 3' ends and the 5' ends of the basic repeating units are linked to form the above-mentioned characteristic amino acid sequence. The recombinant collagen has obvious integrin binding activity, has the effects of promoting cell adhesion, proliferation, differentiation, repairing defects of the cartilage tissue, etc., and has good application prospects.
The present invention provides a method for preparing battery-grade anhydrous iron phosphate from liquid crude monoammonium phosphate, and belongs to the technical field of chemical industry production. In the present invention, ferrous sulfate solution and liquid crude monoammonium phosphate are used as raw materials, and ferrous iron is oxidized to ferric iron and separates out iron phosphate precipitate under the action of an oxidizing agent to obtain iron phosphate intermediate slurry; and then battery-grade anhydrous iron phosphate is finally obtained through solid-liquid separation, washing, aging, solid-liquid separation, washing, drying, dehydration and breaking up. The method provided by the present invention realizes the resource utilization of liquid crude monoammonium phosphate, has simple process and convenient operation and produces less waste water.
A bottom cylinder for a high-temperature and high-pressure environment simulator of a high-fidelity corer is provided. The bottom cylinder includes a cylinder barrel. The bottom of the cylinder barrel is provided with a cylinder base. The piston is provided inside the cylinder barrel and divides an inner cavity of the cylinder barrel into a rodless cavity and a rod cavity. The piston is provided with a piston rod. The outer wall of the cylinder barrel is provided with an oil inlet hole communicated with the rodless cavity, an oil outlet hole communicated with the rod cavity, and a reserved hole. The lower end surface of the piston is provided with a first buffer ring, and the upper surface of the cylinder base is provided with a second buffer ring mated with the first buffer ring. The bottom cylinder is applied to the simulator for oil and gas resource exploitation.
F15B 15/14 - Dispositifs actionnés par fluides pour déplacer un organe d'une position à une autreTransmission associée à ces dispositifs caractérisés par la structure de l'ensemble moteur le moteur étant du type à cylindre droit
F15B 15/22 - Autres parties constitutives pour accélérer ou ralentir le mouvement
SICHUAN PROVINCIAL INSTITUTE OF FORESTRY AND GRASSLAND INVENTORY AND PLANNING (Chine)
Inventeur(s)
Gao, Fei
Li, Nana
Li, Beibei
Li, Tao
Abrégé
A forest stand canopy density measurement method, comprising the following steps: (1) determining a measurement region, and using a flight route passing over the measurement region as a canopy density measurement transect line; (2) carrying an active ranging module on an aircraft, starting the active ranging module, the aircraft executing flight and measurement according to the flight route, measuring a laser ranging distance at each sampling point, and storing sampling point coordinates (x1, y1, z1; x2, y2, z2; xn, yn, zn) of the active ranging module; and (3) comparing the sampling point coordinates (x1, y1, z1; x2, y2, z2; xn, yn, zn) of the active ranging module with take-off point coordinates to obtain height values of the aircraft; calculating the difference between the laser ranging distance (H1, H2, H3) of each sampling point and the corresponding aircraft height, determining whether the difference is greater than a set threshold (F), if yes, determining that no coverage is present at the sampling point, and if not, determining that coverage is present at the sampling point; gathering the results of all sampling points, and calculating the forest stand canopy density. The method has reliable measurement accuracy, a high measurement speed, and a simple measurement process, and can quickly complete forest stand canopy density measurement in batches.
The invention provides a method for evaluating deep-buried tunnel blasting parameters, and belongs to the technical field of mine engineering. The method comprises: setting multiple diverse blasting schemes; selecting a plurality of test sections with the same geological characteristics, the number of the test sections corresponding to the number of the blasting schemes; blasting the test sections using the blasting schemes, and obtaining diversified monitoring data of each test section; and comparing the diversified monitoring data to select the optimal blasting schemes for the test sections. According to the method for evaluating the deep-buried tunnel blasting parameters, by implementing different blasting schemes in test sections with the same geological characteristics, diversified monitoring data of the test sections are obtained and compared to select the optimal blasting schemes for the test sections, so as to ensure the safety and quality of blasting excavation of deep-buried tunnels.
Provided is a method for the glycosylation modification of proteins and/or polypeptides, belonging to the technical field of medicinal chemistry. Using glycosyl sulfinate as a raw material, a method for the glycosylation modification of proteins and/or polypeptides is provided. Reaction raw materials of the present method are easy to obtain, the reaction conditions are mild, the reaction time is short, and the reaction process is controllable. The obtained glycosylation-modified proteins and/or polypeptides have high yield and high purity. The method for glycosylation modification is applicable not only to proteins and/or peptides containing disulfide bonds, but also to proteins and/or peptides containing sulfhydryl groups. The method is even applicable to proteins and/or peptides containing both disulfide bonds and sulfhydryl groups. The application prospects are broad.
C07H 1/00 - Procédés de préparation des dérivés du sucre
C07H 5/10 - Composés contenant des radicaux saccharide dans lesquels les liaisons carbone-oxygène ont été remplacées par le même nombre de liaisons carbone-hétéro-atomes à des atomes d'halogènes, d'azote, de soufre, de sélénium ou de tellure au soufre, au sélénium ou au tellure au soufre
The present disclosure provides a dental bleaching guide plate, including a first plate and a second plate, wherein the first plate and the second plate are abutted to form an enclosed deep groove structure, the first plate is provided with a guide hole, a spacing between two opposite side surfaces of the first plate and the second plate is greater than an outer diameter of a neck of a tooth, and there is a gap between the side surfaces of the first plate and the second plate and side surfaces of the tooth. The guide plate can be sleeved onto an exterior of a tooth to inhibit a bleaching agent from coming into contact with other teeth. In addition, a range and an amount of applying a bleaching agent can be accurately controlled, partitioned coloration and bleaching can be implemented, and an administration position can be accurately located.
The present invention belongs to the technical field of superconducting magnet excitation systems and relates to a split-type alternating current winding, a magnetic flux pump, and a superconducting magnetic flux pump system. The split-type alternating current winding comprises an alternating current winding main body and magnetically conductive teeth; the alternating current winding main body comprises main body teeth; one end of each magnetically conductive tooth is connected to a main body tooth, and the other ends of the magnetically conductive teeth come together in the direction of extension of the main body teeth. The magnetic flux pump comprises the split-type alternating current winding, a direct current winding, and a magnetic yoke; and an air gap is formed between the magnetic yoke and the magnetically conductive teeth of the split type alternating current winding. In the present invention, a split-type alternating current winding is utilized, the problem of tooth expansion and deformation of the alternating current winding is solved, and the difficulty of coil winding is reduced; by adjusting the width of the main body teeth, the ampere-turns of the alternating current winding is improved, and the output performance of the magnetic flux pump is improved; the magnetically conductive teeth are used to guide and concentrate an alternating magnetic field, an output waveform of the magnetic flux pump is adjusted, and the output performance of the magnetic flux pump system is improved.
The present invention relates to the technical field of antibacterial agent preparation, and in particular to an antibacterial finishing agent and a preparation method therefor and a use thereof. The antibacterial finishing agent is prepared by dissolving a polymeric guanidine antibacterial agent, a cyanate monomer, imidazolidinyl urea, a dispersing agent, and an acid in deionized water, carrying out ultrasonic dispersion for 1 h to obtain a dispersion liquid, heating the dispersion liquid in a water bath to 30-80°C, reacting for 5-24 h, cooling to room temperature, and then performing filtering. The antibacterial finishing agent can be simply synthesized, has a water-soluble characteristic, and can be well combined with fabric, such that antibacterial fabric prepared from the antibacterial finishing agent has broad-spectrum, efficient, and lasting antibacterial performance, and is more washable and free of cleaning limitation of anionic detergents compared with some existing commercially available antibacterial fabric products.
D06M 15/37 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone
C08G 73/00 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant de l'azote, avec ou sans oxygène ou carbone, non prévus dans les groupes
Disclosed in the present invention are a desalination-free in-situ direct electrolytic hydrogen production device for a non-pure-water solution, and a use method. The desalination-free in-situ direct electrolytic hydrogen production device comprises an electrolysis system, a water vapor mass transfer layer, a collecting device and a containing device for containing a self-driving electrolyte solution, wherein the water vapor mass transfer layer isolates the electrolysis system from a non-pure-water solution to be electrolyzed, and the water vapor mass transfer layer can make water molecules of said non-pure-water solution enter the electrolysis system by means of phase change migration and can prevent solid and liquid substances in the non-pure-water solution from passing through; and the collecting device is in communication with the electrolysis system and is used for respectively collecting hydrogen and oxygen generated by electrolysis. The present invention solves the problems of incapability of in-situ hydrogen production due to space-time limitations, low electrolytic efficiency, high energy consumption, great increase of cost, catalyst corrosion, membrane blockage, etc., in the existing direct hydrogen production technology for a non-pure-water solution.
An electrolytic hydrogen production system not requiring pure water. The system comprises an energy supply module, an electrolytic hydrogen production module and an electrolyte circulation regeneration module, wherein the energy supply module is connected to the electrolytic hydrogen production module, and the electrolyte circulation regeneration module is connected to the electrolytic hydrogen production module. The electrolyte circulation regeneration module comprises a no-energy-consumption mass transfer device, and only impurity-free water is supplemented to an electrolyte in a no-energy-consumption mass transfer device. The present invention can realize internal self-circulation of an electrolyte, and it is not necessary to supplement an additional electrolyte and purified water to the electrolyte.
The present invention belongs to the technical field of electrolytic hydrogen production, and particularly relates to a direct air electrolysis hydrogen production system. The system comprises an energy supply module, an electrolytic hydrogen production module, an electrolyte circulation regeneration module and a water vapor self-capture module, wherein the energy supply module is connected to the electrolytic hydrogen production module; the electrolytic hydrogen production module comprises an electrolytic cell; and the electrolyte circulation regeneration module is connected to both the electrolytic hydrogen production module and the water vapor self-capture module. By means of the system, direct air electrolysis hydrogen production can be realized; moreover, the electrolysis energy consumption is equivalent to the energy consumption of hydrogen production by industrial electrolysis of purified water, and there is no need for the additional energy consumption of desalinating/purifying a non-pure water solution and capturing moisture in the air. The system greatly broadens the range of hydrogen energy sources, without being limited by space and time, thereby providing technical support for future distributed hydrogen energy layout.
Disclosed is a multi-stage pore hydrogel medicament sustained-release system based on natural polyphenol, which relates to the field of drug delivery. The system comprises a hydrogel matrix and a supramolecular filler. The supramolecular filler is a complex of a natural bio-based polymer and metal ions. The natural bio-based polymer is selected from one of natural polyphenol, dopamine and derivatives thereof, polysaccharide biomass and protein biomass. The hydrogel matrix is one of chitosan, carboxymethyl chitosan, sodium alginate, carboxymethyl cellulose, hyaluronic acid, collagen, gelatin and agarose. The metal ions are one kind of cations of Al, Fe, Zn, Mn, Ni, Co and V. The supramolecular filler based on the natural bio-based polymer is formed in situ in a hydrogel, and is used for regulating and controlling pores of the hydrogel and generating interactions with different medicaments, so that the release rate of the medicament is adjusted. The supramolecular filler is low in cost and free of toxic and side effects.
5+ doping improves the temperature stability of the ceramics by providing a domain wall pinning effect. This result demonstrates the promise of potassium sodium bismuth niobate tantalate zirconate ferrite ceramics for a wide range of applications, including sensors, actuators, and other electronic devices.
C04B 35/495 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes à base d'oxydes de vanadium, de niobium, de tantale, de molybdène ou de tungstène ou de leurs solutions solides avec d'autres oxydes, p. ex. vanadates, niobates, tantalates, molybdates ou tungstates
C04B 35/626 - Préparation ou traitement des poudres individuellement ou par fournées
An integrated acoustic detection and rock direct tensile test machine includes a support frame. A top of the support frame is provided with a top plate and a bearing plate is provided above the top plate. The bearing plate is provided with force transferring rods, lower ends of which are provided with a tensile base. A top of the tensile base is provided with a lower clamp holder and a bottom of the top plate is provided with an upper clamp holder. An upper channel is provided inside the upper clamp holder. The upper channel is provided with an acoustic transmitting probe. A lower channel is provided inside the lower clamp holder. One end of the lower channel is communicated with the outside, the other end is provided with an acoustic receiving probe. The lower channel extends to a bottom of a clamping chamber of the lower clamp holder.
G01N 3/06 - Adaptations particulières des moyens d'indication ou d'enregistrement
G01N 3/08 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression
A rock direct tensile test platform suitable for all material test machines includes a support frame. A top of the support frame is fixed with a top plate, and a bearing plate is provided above the top plate. The bearing plate is provided with a plurality of vertical force transferring rods. The force transferring rods vertically penetrate through the top plate and have a sliding fit with the top plate. Lower ends of the force transferring rods are provided with a tensile base. A top of the tensile base is provided with a lower clamp holder. A bottom of the top plate is provided with an upper clamp holder, and a clamp center of the upper clamp holder coincides with a clamp center of the lower clamp holder.
G01N 3/16 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression appliqués par un mécanisme
97.
NATURAL-POLYPHENOLS-BASED MULTI-STAGE POROUS HYDROGEL SUSTAINED RELEASE DRUG DELIVERY SYSTEM AND ITS PREPARATION METHOD
This invention discloses a natural polyphenols-based, multi-stage porous hydrogel sustained release drug delivery system, which relates to the field of drug delivery. It consists of the hydrogel matrix and the supramolecular filler, which is a complex of natural bio-based polymers and metal ions. The natural bio-based polymer can be natural polyphenols, dopamine or its derivatives, polysaccharide biomass, or protein biomass. The hydrogel matrix can be chitosan, carboxymethyl chitosan, sodium alginate, carboxymethyl cellulose, hyaluronic acid, collagen, gelatin, or agarose. The metal ion can be one of the cations of Al, Fe, Zn, Mn, Ni, Co, or V. By this invention, the supramolecular filler based on natural bio-based polymer can form in situ in the hydrogel, to regulate the pores of the hydrogel and interact with different drugs, thus adjusting the drug release rate.
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
98.
ELASTIC WAVE AND TENSILE DAMAGE TESTING SYSTEM OF ROCK COUPLED WITH SEEPAGE IN DEEP EARTH COMPLEX ENVIRONMENT
A direct tensile and acoustic testing machine under rock seepage includes a sample and a support frame. A top of the support frame is fixed with a top plate, a bearing plate is provided above the top plate, the bearing plate is provided with a plurality of vertical force transferring rods, the force transferring rods vertically penetrate through the top plate and sliding fit with the top plate, lower ends of the force transferring rods are provided with a tensile base, a top of the tensile base is provided with a lower clamp holder, a bottom of the top plate is provided with an upper clamp holder, and a clamp center of the upper clamp holder overlaps with a clamp center of the lower clamp holder. An acoustic component and a seepage component are provided in the upper clamp holder and the lower clamp holder.
G01N 3/08 - Recherche des propriétés mécaniques des matériaux solides par application d'une contrainte mécanique par application d'efforts permanents de traction ou de compression
99.
SEEPAGE AND ACOUSTIC WAVE COUPLING SYSTEM FOR ROCK TENSILE TESTING
Research Institute of Petroleum Exploration & Development, PetroChina Company Limited (Chine)
Sichuan University (Chine)
Inventeur(s)
Liu, Mancang
Qiu, Xiaosong
Liu, Jianfeng
Su, Yunhe
Wu, Zhide
Wang, Lu
Xu, Shujuan
Lai, Xin
Yang, Jianxiong
Xu, Huining
Pei, Jianliang
Wei, Jinbing
Abrégé
A clamping triaxial seepage and acoustic coupling rock tensile testing machine includes a sample and a scaffold-type tensile testing device. The scaffold-type tensile testing device has an upper chuck and a lower chuck. The upper chuck has an acoustic transmitting channel, one end of which communicating with the outside, and the other end of which having an acoustic transmitting probe. The lower chuck has an acoustic receiving channel, one end of which communicating with the outside, and the other end having acoustic receiving probe. An upper end face of the sample has with a seepage outflow hole while the upper chuck has a seepage outflow channel connected with the seepage outflow hole. A lower end face of the sample has a seepage inflow hole while the lower chuck has a seepage entry channel is connected with the seepage inflow hole.
G01N 29/14 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet utilisant des techniques d'émission acoustique
G01N 29/28 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails pour établir le couplage acoustique
The present invention provides a compound represented by formula I, or a pharmaceutically acceptable salt thereof, or a stereoisomer thereof, or a solvate thereof, or a prodrug thereof, or a metabolite thereof, or a deuterated compound thereof. The compound of the present invention takes effect quickly when being used for local anesthesia, the anesthesia effect lasts longer after single administration, and in infiltration anesthesia and block anesthesia, the compound has a long local anesthesia effect even in an inflammatory state, thereby solving the problem of side effects caused by the current use of local anesthetics combined with adrenaline, and achieving better safety. The compound provided by the present invention can be used for preparing safe and long-lasting local anesthetics, and has the advantages of a long local anesthesia effect, less nerve damage, high safety and an anti-inflammatory effect.
brevets
