A dialysis apparatus including a dialyzer with an interior sectioned by a blood purification membrane into blood and dialysis flow paths, a blood circuit including vein and artery passages connected to the blood flow path, and a dialysis fluid circuit including a dialysis fluid supply and fluid retrieval passages connected to the dialysis fluid flow path. The apparatus includes a bypass passage allowing communication between the dialysis fluid supply and retrieval passages, a dialysis fluid supply open/close valve provided between a connection position at which the dialysis fluid supply passage is connected to the bypass passage and the dialyzer, a dialysis fluid discharge open/close valve provided between a connection position at which the dialysis fluid retrieval passage is connected to the bypass passage and the dialyzer, a pressurizing device for pressurizing the dialysis fluid circuit, and a depressurizing device for depressurizing the dialysis fluid circuit and a controlling device.
It is an object of the present invention to provide a drug for preventing or treating a liver disease associated with fibrosis, the drug containing microRNAs as an active ingredient. A pharmaceutical composition for preventing or treating a liver disease associated with fibrosis, the pharmaceutical composition containing at least one kind of microRNAs selected from miR 1237-5p, miR 204-3p, miR 7977, miR 6089, and miR 5787 as an active ingredient, is produced.
A61K 31/7088 - Composés ayant au moins trois nucléosides ou nucléotides
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
Sterilization is efficiently performed with a small amount of sterilizing agent. A first partition plate separating an upstream zone and a downstream zone is provided with an opening for allowing a container holding section that moves according to rotation of a fifth rotation wheel (transfer rotation wheel) to pass through, and the fifth rotation wheel is disposed across the upstream zone and the downstream zone. A first tunnel that allows the container holding section of the fifth rotation wheel to pass through is provided along a movement path of the container holding section, and a sterilizing nozzle for spraying a sterilizing agent toward the container holding section is provided inside the first tunnel. The first tunnel is provided in the downstream zone, at a position adjacent to the opening where the container holding section passes through at a time of entering the upstream zone from the downstream zone.
A container-sterilizer includes a rotating body and a manifold which are configured to rotate coaxially and integrally with a rotational shaft which is rotatably supported by a fixed member. Sterilizing nozzles to inject a sterilizing agent are connected to the manifold. A penetrating member attached to the fixed member is provided in the rotational shaft to pass through the rotational shaft to the manifold. The manifold has supply openings communicating with the sterilizing nozzles. The penetrating member has a shielding member which is provided in the manifold and which is configured to supply the sterilizing agent in the manifold to some supply openings among the plurality of sterilizing nozzles.
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
Provided is a hemodialysis device (1) for quickly stabilizing a replacement fluid when a pressure change suddenly occurs. The hemodialysis device (1) comprises: a replacement fluid passage (5) between a dialysate circuit (4) and a blood circuit (3), said dialysate circuit (4) and replacement fluid passage (5) each being provided with a first and a second flow rate restriction means (MV1, MV2); a connection portion pressure sensor (PG2) for measuring the pressure of a connection portion between a dialysate supply passage (14) and the replacement fluid passage (5); and a vein-side pressure sensor (PV) (blood circuit pressure measurement means) for measuring the pressure of the blood circuit (3). A control means (6) adjusts the opening degree of the second flow rate restriction means (MV2) a plurality of times on the basis of the measured pressure of the connection portion pressure sensor (PG2) and the measured pressure of the vein-side pressure sensor (PV) for one round, defined as being from when a supply compartment of a chamber provided to the dialysate circuit (4) is filled with fresh dialysate until all of the fresh dialysate in the supply compartment has been discharged.
A dialysis apparatus has a replenisher passage selectively connectable to an arterial side passage (pre-replenishment) or a venous side passage (post-replenishment) in a blood circuit. A supply side pressure sensor measures a pressure of a dialysate supply passage and a collection side pressure sensor measures a pressure of a dialysate collection passage. The connection passages each have one end communicating with the arterial side passage or the venous side passage of the blood circuit and another end connected to the dialysate collection passage. It is determined whether the replenisher passage is connected to the arterial side passage or the venous side passage, based on a differential pressure of pressures measured by the supply side pressure sensor and the collection side pressure sensor, in a state where a dialysate pump (liquid delivery device) causes dialysate to flow into the blood circuit from the replenisher passage.
A tube pump having a housing in which a large diameter flexible tube is arranged along a lateral wall formed to have a substantially horseshoe shape, and a roller that moves along the lateral wall of the housing. Between a blockage section which pressures and blocks the large diameter tube and a separation section shaped so as to gradually extend away from the rotation center, the lateral wall is provided with a pressure release section having an arc with a radius larger than the blockage section. While the roller is moving through the pressure release section, a communication opening is formed in the large diameter tube pressured by the roller so as to allow communication between a part positioned on an upstream side and a part positioned on a downstream side of the roller, while a size of the communication opening is maintained to constant.
An article conveyance apparatus conveys containers with carriers moved by a linear driving apparatus. The article conveyance apparatus includes a first upper side linear conveyance rail, a second lower side linear conveyance rail, a first delivery unit that is inverted while holding the carriers to deliver the carriers from a downstream end of the first conveyance rail to an upstream end of the second conveyance rail. A second delivery unit that is inverted while holding the plurality of carriers, delivers the carriers from a downstream end of the second conveyance rail to an upstream end of the first conveyance rail. An interval between the first conveyance rail (forward path) and the second conveyance rail (return path) is reduced as compared with an existing article conveyance apparatus.
A vessel sterilizer includes a gripper which is configured to hold a vessel having an opening facing upward, the endless conveyor being configured to move the gripper in a conveyance direction along a conveyance rout; a nozzle provided on the conveyance rout and configured to inject sterilizing gas from a spout provided at a bottom end of the nozzle toward the opening of the vessel to supply the sterilizing gas into the vessel; and a swing mechanism configured to horizontally swing the gripper forward in the conveyance direction when the vessel held by the gripper approaches the nozzle along the conveyance rout and configured to horizontally swing the gripper rearward in the conveyance direction when the vessel held by the gripper moves away from the nozzle.
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
A filling method includes storing liquid in a liquid tank; pressing a seal member of a filling head against a mouth of a vessel to seal the mouth; providing a liquid valve in a liquid passageway which connects an inside of the liquid tank to the vessel via the filling head; providing a gas valve in a gas passageway connecting a headspace of the liquid tank to the vessel via the filling head; providing a snifting valve in a snifting passage which connects the vessel to an outside via the filling head; detecting an amount of the liquid supplied to the vessel; and when the liquid is a non-fizzy liquid, opening the liquid valve to supply the liquid to the vessel while a compressor pressurizes the inside of the liquid tank, the gas valve is closed, the snifting valve is opened, and the mouth of the vessel is sealed.
A container supplying apparatus includes a supply conveyer conveying containers and a screw engaging with the containers on the supply conveyer and conveying the containers to a downstream side. The screw is divided into an upstream screw and a downstream screw rotationally driven by different servomotors. In a case where no container is supplied to a specific bottle table of a weighing and filling apparatus, the upstream screw is decelerated and is then accelerated relative to the downstream screw. As a result, an interval of the successive containers is expanded, and a large interval is maintained therebetween. This supplies no container to the specific bottle table of the weighing and filling apparatus.
B65G 33/04 - Transporteurs rotatifs à vis ou à hélice pour objets transportés entre une seule vis et des dispositifs de guidage
B65G 47/84 - Roues en forme d'étoiles ou dispositifs à courroies ou chaînes sans fin, les roues ou dispositifs étant dotés d'éléments venant en prise avec les objets
A genetically modified cell that can be mass-produced efficiently. The genetically modified cell production system includes a cell-processing isolator for seeding a T cell in a well plate (culture vessel) a cell culture incubator (cell storage) for holding the culture vessel in which the T cell has been seeded and culturing the T cell a virus-processing isolator (nucleic acid preparation isolator) for providing, to the well plate, a virus having a nucleic acid containing a gene to be introduced into a cell a virus storage (nucleic acid storage) for holding the well plate from the virus-processing isolator and a virus infection isolator (nucleic acid introduction isolator) for introducing the nucleic acid into the T cell by infecting the T cell with the virus.
C12M 1/42 - Appareils pour le traitement de micro-organismes ou d'enzymes au moyen d'énergie électrique ou ondulatoire, p. ex. magnétisme, ondes sonores
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/32 - Inoculateur ou échantillonneur du type à champs multiples ou en continu
A bonding apparatus provided with a gas supplying unit for causing an inert gas to be sprayed from a spray aperture provided adjacent to a holding section of the bonding head. The spray aperture is provided so as to surround the holding section of the bonding head, in which a portion of the slits is a wide slit set to a higher jet flow rate of the inert gas than narrow slits of another portion, and the inert gas sprayed from the wide slit and the narrow slits forms an air curtain that surrounds the bonding portion between the semiconductor chip and the substrate. The inert gas sprayed from the wide slit forms a flow that passes between the semiconductor chip and the substrate.
NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY (Japon)
SHIBUYA CORPORATION (Japon)
Inventeur(s)
Nakashima, Misako
Iohara, Koichiro
Yoneda, Kenji
Murai, Ryosuke
Nagai, Hiroyuki
Abrégé
A dentin regenerative cell culture that can bring about a rapid regeneration of dentin in a deficit region. In the treatment of a tooth using the dentin regenerative cell culture, a root canal where a pulpectomy has been performed is filled with a root canal filler containing dental pulp stem cells. The dentin regenerative cell culture is then implanted in the deficit region of dentin, and temporary sealing with a packing is carried out. The dentin regenerative cell culture is formed three-dimensionally in conformity with the shape of the deficit region with the coalescence of cell masses of a plurality of odontoblasts, and thus the dentin regeneration is well promoted. In addition, gaps between the dentin regenerative cell culture and biological tissue can be rapidly filled. Infection due to bacterial infiltration can thereby be prevented.
A61K 6/884 - Préparations pour la fabrication de dents artificielles, l’obturation ou le recouvrage des dents comprenant des résines naturelles ou synthétiques
A dialysis apparatus has a connection channel that communicatively connects a dialysate circuit and a blood circuit, and circulates dialysate from the dialysate circuit to the blood circuit via the connection channel during a priming operation. A blood pump has a tube attachment device that switches from an unattached state in which a tube is positioned outside a housing and permits liquid to circulate thereinside, to an attached state in which the tube is in the housing and a rotor compresses the tube. At the time of priming, the liquid feeding pump feeds dialysate from the dialysate circuit to the blood circuit via the connection channel. With the blood pump being in the unattached state, the dialysate is circulated past the blood pump, and then, with the blood pump in the attached state, the dialysate is circulated in a direction opposite to the blood pump.
A chuck for a capping machine includes a plurality of chuck members, a biasing member configured to bias the plurality of chuck members radially inward, an abutting portion configured to abut against a top face of a cap, and a plurality of chuck jaws provided on an inner surface of each of the plurality of chuck members to engage knurls of the cap. Each of the plurality of chuck jaws includes a leading flank and a trailing flank. An angle of the trailing flank with respect to an outer circumference of the cap is less than an angle of the leading flank with respect to the outer circumference of the cap.
B67B 3/20 - Fermeture des bouteilles, des bocaux ou des récipients analogues par application de capsules par application et rotation de capsules préalablement filetées
A liquid is efficiently suctioned and discharged from and to a container formed by a plurality of aligned storing portions for storing the liquid, using a plurality of nozzles. Provided is a liquid suction/discharge device including a container support device for supporting a culture container formed by a plurality of aligned storing portions, and a nozzle support device for supporting a plurality of nozzles in a state in which distal ends of the nozzles are directed downward. The nozzle support device includes a nozzle support member that swingably supports the plurality of nozzles using prescribed parts as support points, and the liquid suction/discharge device further includes a nozzle inclination device for causing each of the nozzles to be inclined with respect to the nozzle support member.
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
B67D 7/02 - Appareils ou dispositifs pour transférer des liquides à partir de récipients ou de réservoirs de stockage en vrac vers des véhicules ou des récipients portables, p. ex. pour la vente au détail pour transférer des liquides autres que des carburants ou des lubrifiants
A capping machine includes a gripper having a pair of gripping arms provided on an outer peripheral portion of a rotating body and configured to grip a cylindrical portion of a vessel, an opening and closing device configured to open and close the gripping arms, and a capping head liftably and rotatably provided on the rotating body. The gripping arms are arranged symmetrically with respect to a radius of the rotating body. The gripper has a protrusion for preventing the vessel from rotating on a vessel gripping surface of the gripping arms. The gripping arms have outer and inner gripping surfaces which are connected in a V shape. The protrusion is formed only on the inner gripping surface of a right gripping arm. A cap held by the capping head is screwed onto the vessel while sticking the protrusion into the cylindrical portion.
B67B 3/20 - Fermeture des bouteilles, des bocaux ou des récipients analogues par application de capsules par application et rotation de capsules préalablement filetées
19.
Exosome extraction device and exosome extraction method
A liquid containing exosomes is filtered through a first filter that has a hole diameter that passes the exosomes and blocks cells, and is then stored in a first storage unit (rough filtration step). Next, pressure is applied to the inside of the first storage unit to pump the liquid to a pre-filtration chamber in a second filter that blocks the exosomes so that water in the liquid is filtered out into a post-filtration chamber. The exosome-containing liquid that was not filtered out is returned to the first storage unit, thereby increasing the exosome concentration in the liquid for extraction (concentration step). The exosome-containing concentrate in the first storage unit is then filtered through a third filter having a hole diameter that passes the exosomes and blocks bacteria, and is sent to a recovery unit (sterilization filtration step).
B01D 29/56 - Filtres à éléments filtrants stationnaires pendant la filtration, p. ex. filtres à aspiration ou à pression, non couverts par les groupes Leurs éléments filtrants à plusieurs éléments filtrants caractérisés par leur agencement relatif montés en série
B01D 29/62 - Régénération de la substance filtrante dans le filtre
Weighing and filling apparatus for controlling filling device based on a container weight. A linear actuator for driving a drive shaft coupled to container support unit is included, a weight measuring unit determines the container weight from a detected height of the drive shaft detected by a height detecting unit and a drive signal of the linear actuator at the detected height. A first acceleration signal is calculated from a specified height of the container support unit set in advance and the height detected by the height detecting unit, a second acceleration signal is calculated from the container weight and an expected weight expected to be applied to the container support unit. The container support unit is kept at the specified height by a drive signal calculated from the first and second acceleration signals.
B67C 3/24 - Dispositifs pour supporter ou tenir les bouteilles
B67C 3/20 - Mise en bouteilles de liquides ou de semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analogues permettant la mesure des liquides à introduire, p. ex. quand on ajoute des sirops
B67C 3/22 - Mise en bouteilles de liquides ou de semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analogues Détails
G01B 21/08 - Dispositions pour la mesure ou leurs détails, où la technique de mesure n'est pas couverte par les autres groupes de la présente sous-classe, est non spécifiée ou est non significative pour mesurer la longueur, la largeur ou l'épaisseur pour mesurer l'épaisseur
G01G 7/00 - Appareils de pesée dans lesquels l'équilibrage est assuré par une action magnétique, électromagnétique ou électrostatique, ou par des moyens non prévus dans les groupes
B65B 3/28 - Dispositifs ou procédés pour régler la quantité de matériau fourni ou chargé par pesage
G01G 21/22 - Plateaux de pesée ou autres récipients de peséePlates-formes de pesée
G01G 17/06 - Appareils ou méthodes pour peser un produit ayant une forme ou des propriétés particulières pour peser des fluides, p. ex. des gaz, des produits pâteux et ayant les moyens de commander le remplissage ou la vidange
G01G 23/14 - Dispositifs pour déterminer le poids de la tare ou pour annuler la tare par remise à zéro, p. ex. par une opération mécanique
G01G 13/285 - Aménagements apportés à un mécanisme de pesée pour commander le remplissage ou la vidange automatique comportant la variation d'une variable électrique qui est utilisée pour commander le remplissage ou la vidange du récipient impliquant une comparaison avec une valeur de référence
According to the present invention, a genetically modified cell can be mass-produced efficiently. A genetically modified cell production system 1 includes: a cell-processing isolator 6 for seeding a T cell in a well plate (culture vessel); a cell culture incubator 14 (cell storage) for accommodating the culture vessel in which the T cell was seeded and culturing the T cell; a virus-processing isolator 5 (nucleic acid preparation isolator) for providing, to the well plate, a virus having a nucleic acid containing a gene to be introduced into a cell; a virus storage 13 (nucleic acid storage) for accommodating the well plate from the virus-processing isolator 5; and a virus infection isolator 6 (nucleic acid introduction isolator) for introducing the nucleic acid to the T cell by infecting the T cell with the virus.
To continue a series of cell treatments even in a case where a treatment has become impossible in any isolator, a cell treatment system is provided with at least two isolators that perform different treatments, such that a sequential series of cell treatments is performed in each of the isolators. The cell treatment system is provided with a first isolator that performs a first treatment, a second isolator that performs a second treatment different from the first treatment, and a common isolator capable of performing the first treatment and the second treatment.
NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY (Japon)
SHIBUYA CORPORATION (Japon)
Inventeur(s)
Nakashima Misako
Iohara Koichiro
Yoneda Kenji
Murai Ryosuke
Nagai Hiroyuki
Abrégé
Provided is a dentin regenerative cell culture 4 that can bring about the rapid regeneration of dentin in a deficit region 5. In the treatment of a tooth 1 using the dentin regenerative cell culture 4 according to the present invention, a root canal filler 3 containing dental pulp stem cells is filled into a root canal where a pulpectomy has been performed (FIG. 1a). The dentin regenerative cell culture 4 is then implanted in a deficit region 5 of the dentin 1a, and temporary sealing with a packing 6 is carried out. The dentin regenerative cell culture 4 forms three-dimensionally in conformity with the shape of the deficit region 5 with the coalescence of cell masses 10 of a plurality of odontoblasts, and thus the dentin regeneration is well promoted. In addition, gaps between the dentin regenerative cell culture 4 and biological tissue can be rapidly filled. Infection due to bacterial infiltration can thereby be prevented.
A61K 6/884 - Préparations pour la fabrication de dents artificielles, l’obturation ou le recouvrage des dents comprenant des résines naturelles ou synthétiques
A method for culturing bone marrow-derived mesenchymal stem cells which is capable of efficiently culturing the cells while minimizing the influence of animal-derived serum by use of a serum-free medium. The method includes inoculating cells extracted from a bone marrow fluid to a culture vessel, and performing medium replacement a plurality of times before initial passage, wherein in the inoculation, a medium supplemented with animal-derived serum is used, and in any of the plurality of times of medium replacement, the medium is exchanged with a serum-free medium without the use of the serum, followed by culture in the serum-free medium.
C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
C12N 5/00 - Cellules non différenciées humaines, animales ou végétales, p. ex. lignées cellulairesTissusLeur culture ou conservationMilieux de culture à cet effet
An assembling apparatus efficiently performs a recovery operation and a parts size change operation. A filling line (the assembling apparatus) has parts supply units that supply parts, assembling units that mount one of the parts to another part, and a conveying unit that individually moves carriers 12 capable of storing parts constituting an assembly. The parts supply units are provided at positions away from the assembling units, the assembling units are accommodated in an isolator having an interior maintained in an aseptic state, and gloves to perform an operation on the assembling units are provided on a side surface of the isolator. The supply units store the parts in one of the carriers, the carrier then moves into the isolator, and the assembling units take the part from the carrier, and mounts the part to the other part stored in the same carrier.
B23P 19/04 - Machines effectuant simplement l'assemblage ou la séparation de pièces ou d'objets métalliques entre eux ou des pièces métalliques avec des pièces non métalliques, que cela entraîne ou non une certaine déformationOutils ou dispositifs à cet effet dans la mesure où ils ne sont pas prévus dans d'autres classes pour assembler ou séparer des pièces
B65B 55/02 - Stérilisation, p. ex. de paquets finis
B65B 39/12 - Ajutages, entonnoirs ou guides pour introduire des objets ou matériaux dans les réceptacles ou les emballages pouvant se rapprocher ou s'éloigner du réceptacle ou de l'emballage durant le remplissage
A container processing system includes a filling apparatus and a sterilization apparatus, the filling apparatus including first processing units adapted to process a container held by a gripper at stop positions with a sixth rotating body being rotated while intermittently stopped, the sterilization apparatus including a servomotor adapted to stop the container held by a gripper at an appropriate processing position by driving a second rotating body. During one intermittent motion of the filling apparatus, the sterilization apparatus rotates the gripper of the second rotating body once and thereby moves the gripper from a receiving position for the container to the processing position, stops the gripper there, and then moves the gripper to a transfer position.
This heat-shrinking device for a heat shrinkable label is provided with: a container support means for supporting a container to which a heat shrinkable label is attached; a heating cylinder that is disposed below the container support means and that can house the container supported by the container support means; a heating means for heating the inside of the heating cylinder; a lifting-lowering means for lifting and lowering the container support means and the heating cylinder relatively to each other; and a control means for controlling the lifting-lowering means. The control means causes the lifting-lowering means to lift or lower the container support means and the heating cylinder relatively to each other so as to insert the bottom of the container from the upper end of the heating cylinder, and causes the label attached to the container to be heat-shrunk by positioning the container in the heating cylinder for a prescribed time through control of the speed of the lifting-lowering means.
B65B 53/02 - Contraction des enveloppes, des réceptacles, des couvercles de réceptacles ou des éléments destinés à fixer les couvercles des réceptacles, durant ou après l'emballage par la chaleur
B65B 53/04 - Contraction des enveloppes, des réceptacles, des couvercles de réceptacles ou des éléments destinés à fixer les couvercles des réceptacles, durant ou après l'emballage par la chaleur fournie par liquides
The present invention relates to a weighing and filling device 3 which controls a filling means 6 on the basis of a container weight measured by a weight measuring means. The weighing and filling device is provided with a linear actuator 12 which drives a drive shaft 11 coupled to a container support means 5. A weight measuring unit 9a (weight measuring means) obtains the container weight from a detected height of the drive shaft 11 detected by a height detecting means 13, and a drive signal of the linear actuator 12 at the detected height. The weighing and filling device calculates a first acceleration signal from a predetermined specified height of the container support means 5, and the detected height detected by the height detecting means 13, calculates a second acceleration signal from the container weight obtained by the weight measuring unit 9a and an assumed weight assumed to be acting on the container support means 5, and maintains the container support means 5 at the specified height by means of a drive signal calculated from the first and second acceleration signals. The container weight can be measured rapidly, and trouble when delivering the container can be prevented as far as possible.
B67C 3/20 - Mise en bouteilles de liquides ou de semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analogues permettant la mesure des liquides à introduire, p. ex. quand on ajoute des sirops
B65B 3/28 - Dispositifs ou procédés pour régler la quantité de matériau fourni ou chargé par pesage
G01G 7/00 - Appareils de pesée dans lesquels l'équilibrage est assuré par une action magnétique, électromagnétique ou électrostatique, ou par des moyens non prévus dans les groupes
A container conveyor system includes a first endless conveyor and a second endless conveyor. The first endless conveyor is provided with a plurality of neck grippers that holds the neck of a capped container and conveys the container held by the neck gripper by moving the neck gripper. The second endless conveyor is provided with a plurality of vertical grippers that comprises an upper grip member, which is liftable and abuts against the top of the cap of the container, and a support plate that supports the base of the container. The second endless conveyor conveys the container held by the upper grip member and the support plate by moving the vertical gripper. The container conveyor system conveys the container by transferring the container between the neck gripper and the vertical gripper.
B65G 17/12 - Transporteurs comportant un élément de traction sans fin, p. ex. une chaîne transmettant le mouvement à une surface porteuse de charges continue ou sensiblement continue, ou à une série de porte-charges individuelsTransporteurs à chaîne sans fin dans lesquels des chaînes constituent la surface portant la charge comprenant une série de porte-charges individuels fixés ou normalement fixés à l'élément de traction
B65G 47/52 - Dispositifs pour transférer objets ou matériaux entre transporteurs, p. ex. pour décharger ou alimenter
B65G 47/80 - Tables tournantes portant les objets ou matériaux à transférer, p. ex. combinées avec des lames ou des raclettes
B65G 47/90 - Dispositifs pour saisir et déposer les articles ou les matériaux
30.
Phototherapeutic apparatus and protocol setting method for phototherapeutic apparatus
PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY (Japon)
SHIBUYA CORPORATION (Japon)
Inventeur(s)
Morita, Akimichi
Sakano, Katsutoshi
Abrégé
Provided is a phototherapeutic apparatus including: a probe that is held and operated by a user and provided with a photo-irradiation unit that performs irradiation with light beams; and a body provided with a control unit that controls the light beams. The body is provided with a read unit that reads a treatment protocol registered in an IC card (mobile memory medium), and a monitor (operation indication unit) that indicates a region to be irradiated with the light beams to the user, the region being set in the treatment protocol, and the control unit causes the monitor to indicate the region to be irradiated and causes the photo-irradiation unit to perform the irradiation with the light beams at a set value set in the treatment protocol. It is possible to perform the irradiation with the light beams in accordance with the treatment protocol and safely use the phototherapeutic apparatus.
B65G 47/49 - Dispositifs pour décharger les objets ou matériaux des transporteurs avec distribution, p. ex. automatique, aux points voulus selon des marques de destination portées soit par les objets, soit par les porte-charges sans contact matériel entre l'objet ou porte-charges et le dispositif automatique de commande
B65G 47/42 - Dispositifs pour décharger les objets ou matériaux des transporteurs actionnés par les objets ou matériaux transportés et déchargés
B65G 47/84 - Roues en forme d'étoiles ou dispositifs à courroies ou chaînes sans fin, les roues ou dispositifs étant dotés d'éléments venant en prise avec les objets
B65G 47/64 - Changement de voies des transporteurs
B65G 23/32 - Mécanismes d'entraînement pour transporteurs sans finDispositions de tension des courroies ou des chaînes pour assurer l’entraînement en plusieurs points espacés sur la longueur des transporteurs
B65G 13/06 - Dispositifs d'entraînement des rouleaux
B65G 41/00 - Châssis ou bases de support pour transporteurs dans leur ensemble, p. ex. châssis transportables
B65G 23/23 - Aménagements ou installations des moteurs d'entraînement de moteurs électriques linéaires
A filling system includes a conveyance chamber that conveys vessels, a filling chamber provided with a filling head that fills content into the vessels, a pressure control means that controls the pressure conditions of each chamber, an intermediate chamber that is provided between the conveyance chamber and the filling chamber, and a shutter that can separate the conveyance chamber and the intermediate chamber. When the filling chamber is separated by the shutter, the pressure control means controls the pressure of the intermediate chamber to become lower than the pressure of the conveyance chamber and the filling chamber.
B65B 3/04 - Procédés ou moyens pour charger le matériau dans les réceptacles ou récipients
B67C 3/00 - Mise en bouteilles des liquides ou des semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou des semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analoguesRemplissage des fûts ou barriques avec des liquides ou des semi-liquides
A filling system includes a conveyance chamber in which a center wheel for conveying vessels is housed inside, a filling chamber where filling machines are housed inside, an inlet/outlet wheel that transfers the vessels from the center wheel to the filling machine, an opening that allows conveyance of the vessels, and a shutter that closes the opening. The inlet/outlet wheel includes grippers configured from a fixed section and a movable section. The movable section can be raised or lowered with respect to the rotational axis of the inlet/outlet wheel. When the shutter closes the opening, movable section is raised or lowered by a predetermined amount relative to the fixed section, after which the movable section is rotated by a predetermined amount to a position where it does not interfere with the shutter.
B65B 3/04 - Procédés ou moyens pour charger le matériau dans les réceptacles ou récipients
B67C 3/22 - Mise en bouteilles de liquides ou de semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analogues Détails
B67C 3/24 - Dispositifs pour supporter ou tenir les bouteilles
B67C 7/00 - Opérations combinées de lavage, remplissage et fermeture des bouteillesProcédés ou dispositifs combinant au moins deux de ces opérations
B67C 3/00 - Mise en bouteilles des liquides ou des semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou des semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analoguesRemplissage des fûts ou barriques avec des liquides ou des semi-liquides
B65B 43/46 - Alimentation ou positionnement des sacs, boîtes ou cartons en position dilatée, ouverte ou deboutAlimentation des réceptacles préformés rigides, p. ex. boîtes en fer-blanc, capsules, tubes en verre, flacons, vers la position d'empaquetageMise en place des réceptacles ou récipients au poste de remplissageMaintien des réceptacles ou récipients pendant le remplissage en se servant de griffes
B67C 3/28 - Dispositifs de commande du débit, p. ex. en utilisant des soupapes
A filling system includes a center wheel that conveys vessels, a first filler provided with a plurality of filling heads, a second filler provided with a plurality of filling heads and arranged downstream from the first filler, a first inlet wheel that receives the vessels from the center wheel and supplies the vessels to the first filler, and a second inlet wheel that receives the vessel from the center wheel and supplies the vessels to the second filler. Operation modes are switchable between a first operation mode that conveys the vessels to the first filler and a second operation mode that conveys the vessels to the second filler instead of conveying to the first filler by controlling the reception of the vessels at the first and second inlet wheels.
B67C 3/00 - Mise en bouteilles des liquides ou des semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou des semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analoguesRemplissage des fûts ou barriques avec des liquides ou des semi-liquides
B65B 3/04 - Procédés ou moyens pour charger le matériau dans les réceptacles ou récipients
B67C 7/00 - Opérations combinées de lavage, remplissage et fermeture des bouteillesProcédés ou dispositifs combinant au moins deux de ces opérations
B67C 3/02 - Mise en bouteilles de liquides ou de semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analogues
This dialysis device is configured so that residual liquid in a powder container 42 and a bypass path 51 can be drained. Accordingly, the dialysis device is provided with: a first liquid draining path 71 connecting a clean water supply path 31 to a stock solution supply path 44 on the upstream side of a liquid feed pump 33; a second liquid draining path 72 connecting the clean water supply path to a dialysate discharge path 32 on the downstream side of the liquid feed pump; and an opening path 77 allowing a branch path 43 to communicate with the outer space by opening an on-off valve 78. By opening the on-off valve of the opening path and actuating the liquid feed pump, a liquid in the powder container 42 and a liquid in the bypass path 51 can be discharged through the first liquid draining path and the second liquid draining path.
B01F 35/221 - Commande ou régulation des paramètres de fonctionnement, p. ex. du niveau de matière dans le mélangeur, de la température ou de la pression
B01F 101/00 - Mélange caractérisé par la nature des matières mélangées ou par le domaine d'application
a of the main connection part 6 on the work space W side. A manual incubator 3 (first auxiliary aseptic device) includes a first auxiliary connection part 7 connectable with the main connection part 6 of the main isolator 2, and an automatic incubator 4 and a housing container 5 (second auxiliary aseptic devices) each include a second auxiliary connection part 8 smaller than the first auxiliary connection part 7. In addition, an external blockage member 9 configured to externally block the opening O of the main connection part 6 is provided.
B25J 21/02 - Boîtes à gants, c.-à-d. enceintes dans lesquelles les manipulations sont exécutées par des mains humaines dans des gants faisant partie de la paroi de l'enceinteGants de boîtes à gants
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
B25J 21/00 - Enceintes à dispositifs de manipulation intégrés
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
A filling valve for filling liquid into a bottle is provided that comprises a nozzle having an outlet on its bottom end and a seat on its interior surface, a stem arranged inside the nozzle and having a plug provided on its outer periphery, a helical vane provided on the outer periphery of the stem for inducing a spiral flow, and a bevel with expanding diameter in the downward direction is provided at the bottom end of the stem. The filling valve is closed when the stem descends and the plug makes contact with the seat. The filling valve is opened when the stem ascends and the plug separates from the seat. The bevel is extended below the outlet when the plug is opened. The liquid revolved via the helical vane and ejected from the outlet is spread by the bevel toward a bottle finish or neck.
Endotoxin is detected by electrochemical measurement. A detection device 15 of endotoxin detects endotoxin contained in a fluid to be tested (for example, a dialysate) specifically in the following manner. First, the fluid to be tested is brought into contact with an adsorbent 17 that adsorbs endotoxin to cause the adsorbent 17 to adsorb the endotoxin. Then, a basic solution is brought into contact with the adsorbent 17 to desorb the endotoxin. Electrochemical measurement of the basic solution containing the desorbed endotoxin is performed. The endotoxin can be detected by the electrochemical measurement with high sensitivity at low cost.
G01N 33/49 - Analyse physique de matériau biologique de matériau biologique liquide de sang
G01N 33/579 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir un lysat de limulus
A surface treatment method and a surface treatment device 2 for a resin vessel 1 forms a coating or performs surface modification on the surface of the resin vessel 1. In a sterilized environment as well as an environment with a pressure equal to or higher than the atmospheric pressure, a material for the coating or the surface modification is attached to at least one of an inner surface and an outer surface of the resin vessel 1, and the resin vessel 1, to which the material is attached, is irradiated with an electron beam to perform the coating or the surface modification. It is possible to form the coating or perform the surface modification on the resin vessel at a high speed.
B29C 71/04 - Post-traitement d'objets sans modification de leur formeAppareils à cet effet par énergie ondulatoire ou rayonnement corpusculaire
A61L 2/08 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des phénomènes physiques des radiations
B05D 7/22 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers à des surfaces internes, p. ex. à l'intérieur de tubes
B05D 3/06 - Traitement préalable des surfaces sur lesquelles des liquides ou d'autres matériaux fluides doivent être appliquésTraitement ultérieur des revêtements appliqués, p. ex. traitement intermédiaire d'un revêtement déjà appliqué, pour préparer les applications ultérieures de liquides ou d'autres matériaux fluides par exposition à des rayonnements
B29C 35/08 - Chauffage ou durcissement, p. ex. réticulation ou vulcanisation utilisant l'énergie ondulatoire ou un rayonnement corpusculaire
B05D 7/02 - Procédés, autres que le flocage, spécialement adaptés pour appliquer des liquides ou d'autres matériaux fluides, à des surfaces particulières, ou pour appliquer des liquides ou d'autres matériaux fluides particuliers à des substances macromoléculaires, p. ex. à du caoutchouc
09 - Appareils et instruments scientifiques et électriques
Produits et services
Laboratory apparatus and instruments for laboratory and research use, namely, robotic cell culture systems comprised of robot, and chamber; laboratory apparatus and instruments for microorganism, bacteria and cell culture, namely, robotic microorganism, bacteria and cell culture systems comprised of robot, and chamber
In an aeration method for an isolator system, an incubator is connected to an isolator through a chamber. After closing a door at each sidewall of the chamber, a decontaminating gas is supplied to the chamber through gas supply passages to decontaminate the inside thereof. Next, air is supplied into the chamber through the gas supply passages and an initial aeration is carried out by discharging the decontamination gas through a gas discharge passage. Then, after a door between the isolator and the chamber is opened, and blowers are stopped, gas at a positive pressure in the isolator is introduced into the chamber. The decontaminating gas in the chamber is rapidly discharged to an outside through the gas supply passages and the gas discharge passage, and aeration in the chamber is completed.
The time required for aeration of the chamber can be drastically reduced as compared with conventional aeration processes.
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
A schedule management system 1 having isolators 3 (production facilities) and a main control device 4 for managing a production schedules of all the isolators 3. The production process of each isolator constituting the production schedule has a plurality of sub-processes, the production status being determined in the sub-process. The main control device 4 adds a new separating operation to the passage process and performs an update when the main control device 4 obtains a determination result that the separation of cells in a separation state confirmation operation (sub-process) in the passage process is insufficient while a passage process for cells A is being carried out in the isolators. The main control device 4 alters the start time of a culture medium exchange process for other cells B different from the updated passage operation, and updates the production schedule.
G06Q 10/06 - Ressources, gestion de tâches, des ressources humaines ou de projetsPlanification d’entreprise ou d’organisationModélisation d’entreprise ou d’organisation
b.
The idler wave L2 enters as the seed beam L2′ together with the pumping beam L1′ into the nonlinear crystal and thus a terahertz wave with a large output and including a plurality of wavelengths can be generated.
A filling nozzle provided with a filling cylinder, an air-injection cylinder, and an air-supply unit. The filling cylinder is configured such that an auger rotates about the axis thereof to discharge powder through an opening provided at the lower end of the filling cylinder. The air-injection cylinder is fitted to the exterior of the filling cylinder to form an annular space between the filling cylinder and the air-injection cylinder. The air-supply unit supplies air in the annular space. A tip portion of the air-injection cylinder extends downward below the opening and has an air-discharge mouth formed in a tapered shape such that the tip portion has a diameter smaller than that of the opening.
B65B 1/16 - Procédés ou moyens pour remplir les réceptacles ou les récipients avec le matériau par des moyens pneumatiques, p. ex. par aspiration
B65B 1/12 - Procédés ou moyens pour remplir les réceptacles ou les récipients avec le matériau par alimenteurs rotatifs du type à vis
B65B 39/02 - Ajutages, entonnoirs ou guides, expansibles ou rétractables
B65B 39/12 - Ajutages, entonnoirs ou guides pour introduire des objets ou matériaux dans les réceptacles ou les emballages pouvant se rapprocher ou s'éloigner du réceptacle ou de l'emballage durant le remplissage
45.
METHOD AND APPARATUS BOTH FOR PRODUCING CELL AGGREGATE STRUCTURE
A method for producing a cell aggregate structure comprises: a supply step of holding a cell agglutinate clump 2 on a holding section H composed of multiple pins 16 that are provided so as to stand in a culture vessel 3; a culturing step of culturing the cell agglutinate clump 2 held on the holding section H to form a cell aggregate structure (an adhesion pad 4); a detachment step of detaching the adhesion pad 4 formed in the culturing step from the holding section H; and an injection step of injecting an injectant into the adhesion pad 4 detached in the detachment step through through-holes 4a that are formed by the pins 16 and open into the adhesion pad 4. It becomes possible to produce a cell aggregate structure having a desired shape and a desired dimension.
A pumping beam L1 is caused to be incident on an end surface 4A of a nonlinear crystal 4, and a seed beam L2, the diameter of which is increased by a concave lens 6, is collected and adjusted into a collimated beam by a convex lens 7 and caused to be incident on the end surface 4A described above. The pumping beam L1 and the seed beam L2 are caused to be incident on the end surface 4A with the pumping beam L1 and the seed beam L2 superimposed on each other, whereby the nonlinear crystal 4 generates a terahertz wave TH.
A terahertz wave generator 1 includes a nonlinear crystal 4, which is capable of generating a terahertz wave TH, a pumping beam emitter 2, which emits a pumping beam L1, a seed beam emitter 3, which is disposed so as to be parallel to a nonlinear crystal 4 and emits a seed beam L2, a first total reflection mirror 17 and a second total reflection mirror 18, which successively reflect the seed beam L2 emitted from the seed beam emitter 3 to cause the seed beam L2 to be incident on the nonlinear crystal 4, and a convex lens 6, which collects the seed beam L2.
This filling system 10 is provided with: a centre wheel 18 for conveying containers V; a first filler 12 having, provided thereto, a plurality of filling heads; a second filler 14 which is provided further downstream than the first filler 12, and which has, provided thereto, a plurality of filling heads; a first supply wheel 12A which receives the containers V from the centre wheel 18, and supplies the containers V to the first filler 12; and a second supply wheel 14A which receives the containers V from the centre wheel 18, and supplies the containers V to the second filler 14. By controlling the reception of the containers V by the first and second supply wheels 12A, 14A, the operation mode can be switched between a first operation mode in which the containers V are conveyed to the first filler 12, and a second operation mode in which the containers V are conveyed to the second filler 14 without being conveyed to the first filler 12.
B65B 3/04 - Procédés ou moyens pour charger le matériau dans les réceptacles ou récipients
B67C 3/00 - Mise en bouteilles des liquides ou des semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou des semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analoguesRemplissage des fûts ou barriques avec des liquides ou des semi-liquides
B67C 7/00 - Opérations combinées de lavage, remplissage et fermeture des bouteillesProcédés ou dispositifs combinant au moins deux de ces opérations
This filling system 10 is provided with: a conveyance chamber 19 in which containers V are conveyed; a filling chamber 30 in which a filling head 38 for filling the containers V with contents is disposed; a pressure control means 44 for controlling the pressure state between each of the chambers; an intermediate chamber 36 provided between the conveyance chamber 19 and the filling chamber 30; and a shutter 40 which is capable of partitioning the conveyance chamber 19 and the intermediate chamber 36. When the filling chamber 30 is partitioned by the shutter 40, the pressure control means 44 controls the pressure of the intermediate chamber 36 so as to be lower than the pressures of the conveyance chamber 19 and the filling chamber 30.
B67C 3/00 - Mise en bouteilles des liquides ou des semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou des semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analoguesRemplissage des fûts ou barriques avec des liquides ou des semi-liquides
B65B 3/04 - Procédés ou moyens pour charger le matériau dans les réceptacles ou récipients
This filling system (10) is provided with: a conveyance chamber (19) in which a centre wheel (18) for conveying containers is accommodated; a filling chamber (30) in which filling machines are accommodated; a supply/discharge wheel (34) which transfers the containers from the centre wheel (18) to the filling machines; an opening which allows the containers to be conveyed; and a shutter (40) which closes the opening. The supply/discharge wheel (34) is provided with grippers (34G) comprising a fixed block (340) and a movable block (341). The movable block (341) is capable of being raised and lowered with respect to the rotational axis of the supply/discharge wheel (34). When the shutter (40) closes the opening, the movable block (341) is raised or lowered by a prescribed amount relative to the fixed block (340). The movable block (341) is subsequently rotated a prescribed amount to a position in which the movable block does not interfere with the shutter (40).
B67C 3/00 - Mise en bouteilles des liquides ou des semi-liquidesRemplissage des bocaux ou bidons avec des liquides ou des semi-liquides en utilisant des appareils de mise en bouteilles ou des appareils analoguesRemplissage des fûts ou barriques avec des liquides ou des semi-liquides
B65B 3/04 - Procédés ou moyens pour charger le matériau dans les réceptacles ou récipients
51.
CELL CULTURE MEDIUM AND METHOD FOR CULTURING CELLS
The object of the present invention is to provide a medium containing a specific cytokine and thus capable of growing and culturing many cells in a short period of time. The present invention pertains to a cell culture medium for proliferating and culturing cells, the medium containing MIG and I-309.
A61K 35/24 - MucusGlandes des muqueusesBoursesLiquide synovialLiquide articulaireExcretaLiquide céphalorachidien
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
In an operating room 8, about 40 mL of the bone marrow fluid 10 of a patient is sampled and housed in a collection tube 11. Then, the collection tube 11 is conveyed into an isolator 2 in a sterile state. In the isolator 2, the bone marrow fluid 10 in the collection tube 11 is pipetted into test tubes 13, culture tubes 14, etc. To the bone marrow fluid 10 in the culture tubes 14, an erythrocyte sedimentation agent is added. After thus precipitating erythrocytes, the supernatant is collected. From the collected supernatant, a bone marrow cell-containing fraction for liver regeneration is concentrated. The obtained concentrate is pipetted into flasks 5 (culture containers). Then, the flasks 5 are conveyed into an incubator 4 to start cell incubation. From the isolator 1, test tubes 13 and 16 are taken out. The bone marrow fluid 10 in the test tubes 13 and 16 and the concentrate are subjected to a safety inspection, etc. Thus, the safety of the bone marrow fluid 10 sampled from the patient can be inspected immediately after starting the incubation.
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
A61P 9/10 - Médicaments pour le traitement des troubles du système cardiovasculaire des maladies ischémiques ou athéroscléreuses, p. ex. médicaments antiangineux, vasodilatateurs coronariens, médicaments pour le traitement de l'infarctus du myocarde, de la rétinopathie, de l'insuffisance cérébro-vasculaire, de l'artériosclérose rénale
A61P 13/12 - Médicaments pour le traitement des troubles du système urinaire des reins
C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
This dialysis device is configured so that residual liquid in a powder container 42 and a bypass path 51 can be withdrawn. Accordingly, the dialysis device is provided with: a first liquid withdrawal path 71 connecting a clean water supply path 31 to a stock solution supply path 44 on the upstream side of a liquid feed pump 33; a second liquid withdrawal path 72 connecting the clean water supply path to a dialysate discharge path 32 on the downstream side of the liquid feed pump; and an opening path 77 allowing a branch path 43 to communicate with the outer space by opening an opening/closing valve 78. By opening the opening/closing valve of the opening path and actuating the liquid feed pump, a liquid in the powder container 42 and a liquid in the bypass path 51 can be discharged through the first liquid withdrawal path and the second liquid withdrawal path. It is possible to prevent the liquid in the powder container 42 and the bypass path 51 from leaking to the outside when the powder container 42 is removed from the branch path 43 and the stock solution supply path 44 or when the bypass path 51 is detached from the branch path and the stock solution supply path.
An isolator comprises a manipulation chamber isolated from the external atmosphere, a door for opening and closing a portal formed on the manipulation chamber, a linear guide mechanism for guiding a linear motion of a front-side edge of the door along the portal, and a rotation guide mechanism defining a rotation of the door about an axis coinciding with the front-side edge. The door is closed by positioning the front-side edge at the front side of the manipulation chamber, and the door is opened inward into the manipulation chamber by moving the front-side edge toward the back side while rotating the door about the front-side edge.
B25J 21/02 - Boîtes à gants, c.-à-d. enceintes dans lesquelles les manipulations sont exécutées par des mains humaines dans des gants faisant partie de la paroi de l'enceinteGants de boîtes à gants
E05D 15/30 - Suspensions pour battants portés sur des bras mobiles dans un plan horizontal à bras pivotants et guides coulissants
E05D 15/58 - Suspensions pour battants à mouvements successifs différents à mouvements aussi bien de "va-et-vient" que coulissant
E05D 15/36 - Suspensions pour battants se déplaçant le long de glissières disposées de manière qu'un élément-guide du battant se déplace dans un sens sensiblement perpendiculaire au mouvement d'un autre élément-guide
55.
METHOD AND DEVICE FOR FRUIT VEGETABLE STERILIZATION
A method for fruit vegetable sterilization wherein a strawberry 1 (fruit vegetable), which has a hull 1b sticking thereto and is housed in a package P, is sterilized by irradiating with an electron beam W, and a device therefor. The incident electron beam W is allowed to enter from the direction of the hull 1b sticking to the strawberry 1 so that the part of the strawberry 1 in the shadow of the hull 1b is sterilized. Upon the sterilization, the strawberry 1 is housed in a standing state in the package P. Alternatively, the electron beam is magnetically polarized so as to allow the incident electron beam to enter the package from the direction of the hull. This method can extend the storage period of fruit vegetables.
A23L 3/26 - Conservation des aliments ou produits alimentaires, en général, p.ex. pasteurisation ou stérilisation, spécialement adaptée aux aliments ou produits alimentaires par irradiation sans chauffage
PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (Japon)
BIOMEDICA SOLUTIONS CO., LTD. (Japon)
SHIBUYA CORPORATION (Japon)
Inventeur(s)
Taniguchi, Hideki
Takebe, Takanori
Sekine, Keisuke
Nakao, Atsushi
Hiromatsu, Takashi
Sunayama, Hironobu
Nishimura, Tetsuya
Abrégé
An operation isolator forms an aseptic space. An incubator is connected to the operation isolator, in which cells are stored and cultured. A storage chamber stores articles used in the operation isolator. In order to carry articles from the outside into the storage chamber, a decontamination pass-box is provided. The storage chamber and the operation isolator are directly or indirectly connected to each other.
b; and an unfiltered fluid lead-out port 55 through which unfiltered fluid is lead out from the upper part of the housing to a waste fluid flow path 57. When removing the filter from a dialysis fluid circuit 4, fluid is suctioned from the inside of the housing via the upstream-side flow path by using fluid suction means 64A, and a gas is caused to flow into the housing from at least either one of the waste fluid flow path and the downstream-side flow path by using gas inflow means 65. The fluid may be suctioned from the downstream-side flow path and the gas may be caused to flow in from the upstream-side flow path, or the fluid may be suctioned from the waste fluid flow path and the gas may be caused to flow in from the downstream-side flow path. Residual fluid in the filter can be reduced.
B01D 65/00 - Accessoires ou opérations auxiliaires, en général, pour les procédés ou les appareils de séparation utilisant des membranes semi-perméables
An isolator system 1 includes: a main isolator 3 in which an aseptic state is maintained and which is for performing an aseptic operation; an incubator 4 in which the aseptic state is maintained and which is connected to the main isolator 3 and is for culturing cells and the like; decontamination means 35 for decontaminating the inside of the main isolator 3; and a decontamination station 9 that decontaminates the inside of the incubator 4. The isolator system 1 further includes a blocking member 30 for sealing a connection port 13 from the outside, the port being provided in the main isolator 3 and being for connection with the incubator 4. When the inside of the main isolator 3 is decontaminated, the connection port 13 is sealed from the outside with the blocking member 30. The isolator system that can efficiently decontaminate the main isolator and the subisolator connected to this main isolator can be provided.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
Method for evaluating mesenchymal stem cell activity, method for culturing mesenchymal stem cells, method for producing therapeutic agent for liver dysfunction, and therapeutic agent for liver dysfunction
A method for evaluating the activity level of mesenchymal stem cells, and a method for culturing mesenchymal stem cells using the evaluation method in the field of culturing mesenchymal stem cells for regenerative medicine, and further, a method for producing a therapeutic agent for liver dysfunction and a therapeutic agent for liver dysfunction. This method for evaluating mesenchymal stem cell activity has an assay step for assaying the amount of adenylate kinase 4 (AK4) in the mesenchymal stem cells; and a determination step for determining the activity level of the mesenchymal stem cells from the assayed amount of adenylate kinase 4.
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
60.
VITRIFICATION STABILIZER FOR ANIMAL CELL CRYOPRESERVATION FLUID
JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (Japon)
SHIBUYA CORPORATION (Japon)
Inventeur(s)
Matsumura,kazuaki
Naka,toshiaki
Abrégé
Provided are a vitrification stabilizer for an animal cell cryopreservation fluid, and an animal cell cryopreservation fluid which exhibits superior vitrification capabilities due to the animal cell cryopreservation fluid containing the vitrification stabilizer for an animal cell cryopreservation fluid. The vitrification stabilizer for an animal cell cryopreservation fluid contains: an amphoteric polymer compound selected from the group consisting of (a) a carboxylated amphoteric polymer compound obtained by reacting ε-poly-L-lysine with butyl succinic anhydride, (b) a carboxylated amphoteric polymer compound obtained by reacting ε-poly-L-lysine with butyl succinic anhydride and succinic anhydride, or (c) a carboxylated amphoteric polymer compound obtained by reacting ε-poly-L-lysine with a compound represented by formula I; and (d) a sucrose polymer macromolecule to which epichlorohydrin has been crosslinked.
In a terahertz wave generation apparatus including a first non-linear optical crystal 3 on which first laser L1 and second laser L2 from laser generation means 2 are incident to generate terahertz wave TH1, the laser generation means includes a second non-linear optical crystal 7 on which laser having the same wavelength as that of the second laser is incident to generate idler light L1 including a plurality of wavelengths, and makes the idler light L1 generated from the second non-linear optical crystal incident on the first non-linear optical crystal as the first laser L1, to generate terahertz wave including a plurality of wavelengths from the first non-linear optical crystal 3, and wavelength selection means including a transmission section which transmits an idler light having the specific wavelength in the idler light including the plurality of wavelengths can be provided, as needed. Thus, terahertz wave having a high output power and including a plurality of wavelengths can be obtained, and the wavelength selection means easily obtains a required terahertz wave having the specific wavelength.
G02F 1/39 - Optique non linéaire pour la génération ou l'amplification paramétrique de la lumière, des infrarouges ou des ultraviolets
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
G02F 2/02 - Changement de fréquence de la lumière, p. ex. par compteurs quantiques
a maintained in a sterile state, first and second robots 6 and 7 are arranged so that the movable ranges thereof partially overlap each other, and such that liquid supply means 10 which supplies liquids, containing a culture medium and liquid medicine, to containers held by the robots, and temporary placement sections (handing-over table 42, centrifuge tube holder 43, and heated room 44), each of which hands over the containers between the first and second robots, are provided in the movable ranges of the first and second robots, which ranges overlap each other.
The first robot takes out the containers housed in housing means (rotary stocker 8), and the second robot holds and transports the containers handed over from the first robot via the temporary placement section.
The cultivating operation can be efficiently performed.
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
G01N 35/02 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet en utilisant une série de récipients à échantillons déplacés par un transporteur passant devant un ou plusieurs postes de traitement ou d'analyse
G01N 35/10 - Dispositifs pour transférer les échantillons vers, dans ou à partir de l'appareil d'analyse, p. ex. dispositifs d'aspiration, dispositifs d'injection
C12M 1/02 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens d'agitationAppareillage pour l'enzymologie ou la microbiologie avec des moyens d'échange de chaleur
C12M 1/24 - Appareillage pour l'enzymologie ou la microbiologie en forme de tube ou de bouteille
A decontamination operation chamber is partitioned into a first operation chamber and a second operation chamber. A connecting portion that connects the first operation chamber and the second operation chamber can be closed. The pressure of the first operation chamber and the second operation chamber is adjusted by a pressure-adjusting mechanism. When the connecting portion is opened and the first operation chamber and the second operation chamber are connected, an inlet portion for the first operation chamber and an outlet portion for the second operation chamber are closed and air flow is generated from the second operation chamber to the first operation chamber by the pressure-adjusting mechanism. When carrying an object into an aseptic manipulation chamber, the object is housed in the first operation chamber and a first decontamination operation is performed, then the object is transferred to the second operation chamber and a second decontamination operation is performed.
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
F24F 3/16 - Systèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par purification, p. ex. par filtrageSystèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par stérilisationSystèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par ozonisation
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
A sterile work can be applied by a worker 29 to cells or the like through a glove 28 provided in an isolator 15. A work headset 31 outputting a work procedure of the sterile work vocally is prepared for the worker, and a check input device 39 is prepared for a checker 36. A management device 12 outputs the work procedure of the sterile work this time vocally to the work headset. When the fact that the worker has normally performed the sterile work this time is checked by the checker, and when the fact is input from the check input device to the management device, the management device performs the subsequent work procedure. Since the sterile work by the worker 29 can be monitored by the checker 36, a wrong work can be prevented from being performed.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
F24F 3/16 - Systèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par purification, p. ex. par filtrageSystèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par stérilisationSystèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par ozonisation
The present invention pertains to a schedule management system 1 having a plurality of isolators 3 (production facilities) and a main control device 4 for managing the production schedules of all the isolators 3. The production process of each isolator constituting the production schedule is composed of a plurality of sub-processes, the production of a product being determined in the sub-processes. The main control device 4 adds a new separation operation to the passage process and performs an update when the main control device 4 obtains a determination result that the separation of cells in a separation state confirmation operation (sub-process) in the passage process is insufficient while a passage process for cells A is being carried out in the isolators. Furthermore, the main control device 4 alters the start time of a culture medium exchange process for other cells B different from the updated passage operation, and updates the production schedule. The production schedule can be automatically managed.
An incubator 1 includes a cultivating chamber 4 for cultivating culture in a plurality of containers 3 and a supply device 5 provided outside the cultivating chamber 4 and supplying steam into the cultivating chamber 4 for humidification. The supply device 5 includes a supply chamber 5A in which a tray 42 for reserving water is accommodated and an ultrasonic atomizing device 43 for atomizing water. The water in the tray 42 is easily made into steam by the ultrasonic atomizing device 43, passes through an HEPA filter 45 provided in an opening portion 5B and is supplied into the circulation passage 37 of the cultivating chamber 4.
An aseptic manipulation system comprises first and second operation chambers, an aseptic manipulation chamber, and a control unit. The control unit controls the ventilation of the first operation chamber for more than a first specified number of times, after an object is introduced into the first operation chamber, and ventilates the second operation chamber for more than a second specified number of times that is greater than the first specified number of times, after the object is transferred into the second operation chamber from the first chamber.
B25J 21/02 - Boîtes à gants, c.-à-d. enceintes dans lesquelles les manipulations sont exécutées par des mains humaines dans des gants faisant partie de la paroi de l'enceinteGants de boîtes à gants
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
A61L 2/24 - Appareils utilisant des opérations programmées ou automatiques
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
68.
Cell peeling identification device and cell peeling identification method
The present invention relates to a cell peeling recognizing device and a cell peeling recognizing method.
a recognizes the peeled state of cells C by comparing various sets of the captured imaging data. The peeled state of cells in the culture vessel can be determined with high precision.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
G01J 1/42 - Photométrie, p. ex. posemètres photographiques en utilisant des détecteurs électriques de radiations
G01N 33/483 - Analyse physique de matériau biologique
PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY (Japon)
BIOMEDICA SOLUTION CO., LTD. (Japon)
SHIBUYA CORPORATION (Japon)
Inventeur(s)
Taniguchi Hideki
Takebe Takanori
Sekine Keisuke
Nakao Atsushi
Hiromatsu Takashi
Sunayama, Hironobu
Nishimura, Tetsuya
Abrégé
A work isolator 21 forms an aseptic space. An incubator 33 is connected to the work isolator 21, and stores and cultures cells. A storage chamber 52 stores an article used in the work isolator 21. A decontamination pass box 51 is provided for bringing an article into the storage chamber 52 from outside. The storage chamber 52 and the work isolator 21 are directly or indirectly linked.
A filter CF1 for filtering dialysis fluid comprises the following: a housing 52 inside of which a filter material 51 is accommodated and which is vertically long; an introduction port 53 that is disposed in the lower part of the housing and that introduces dialysis fluid from an upstream-side flow path 23a; a filtered fluid lead-out port 54 through which filtered dialysis fluid, which has passed through the filter material, is lead out from the upper part of the housing to a downstream-side flow path 23b; and an unfiltered fluid lead-out port 55 through which unfiltered fluid is lead out from the upper part of the housing to a waste fluid flow path 57. When removing the filter from a dialysis fluid circuit 4, fluid is suctioned from the inside of the housing via the upstream-side flow path by using a fluid suction means 64A, and a gas is caused to flow into the housing from the waste fluid flow path and/or the downstream-side flow path by using a gas inflow means 65. The fluid may be suctioned from the downstream-side flow path and the gas may be caused to flow in from the upstream-side flow path, or the fluid may be suctioned from the waste fluid flow path and the gas may be caused to flow in from the downstream-side flow path. Residual fluid in the filter can be reduced.
A61M 1/14 - Systèmes de dialyseReins artificielsOxygénateurs du sang
71.
METHOD FOR EVALUATING MESENCHYMAL STEM CELL ACTIVITY, METHOD FOR CULTURING MESENCHYMAL STEM CELLS, METHOD FOR PRODUCING THERAPEUTIC AGENT FOR LIVER DYSFUNCTION, AND THERAPEUTIC AGENT FOR LIVER DYSFUNCTION
The present invention relates to a method for evaluating the extent of mesenchymal stem cell activity, and a method for culturing mesenchymal stem cells using the evaluation method in the field of culturing mesenchymal stem cells for regenerative medicine, and further, a method for producing a therapeutic agent for liver dysfunction and a therapeutic agent for liver dysfunction. This method for evaluating mesenchymal stem cell activity comprises an assay step for assaying the amount of adenylate kinase 4 (AK4) in mesenchymal stem cells and an assessment step for assessing the extent of mesenchymal stem cell activity from the assayed amount of AK4. In this method the extent of mesenchymal stem cell activity can be evaluated from the assayed amount of AK4, for instance, if the extent of mitochondrial activity of mesenchymal stem cells is high the mesenchymal stem cells can be evaluated as ideal for use as a therapeutic drug, while if mitochondrial activity of the mesenchymal stem cells is low and aging does not proceed, the mesenchymal stem cells can be evaluated as suitable for subculture.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61K 35/28 - Moelle osseuseCellules souches hématopoïétiquesCellules souches mésenchymateuses de toutes origines, p. ex. cellules souches dérivées de tissu adipeux
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61P 1/16 - Médicaments pour le traitement des troubles du tractus alimentaire ou de l'appareil digestif des troubles de la vésicule biliaire ou du foie, p. ex. protecteurs hépatiques, cholagogues, cholélitholytiques
C12Q 1/48 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une transférase
An automatic culturing device having provided therein: a liquid supply means (10) arranged inside a work chamber (2a) maintained in a sterile state, said arrangement being such that part of the movement range for first and second robots (6, 7) overlaps, said liquid supply means supplying liquid including a culture medium or a liquid drug to containers held by the robots, in the overlapping movement range of the first and second robots; and a temporary placement section (handing over table (42), centrifuge tube holder (43), heated room (44)) for the handing over of the containers between the first and second robots. The first robot takes out the containers which have been housed inside a housing means (rotary stocker (8)) and the second robot holds and moves the containers handed over from the first robot via the temporary placement section. Efficient culturing can occur.
An isolator (2) has at least two communication ports (2dA, 2dB) and couples incubators (4) to each communication port via a coupling member (114 (connection means (111)). In a state in which one communication port (2dA) and a loading port (4d) of the incubator (4) connected to same are open and a work chamber (2a) and the inside of the incubator (4) can be connected, the other communication port (2dB) and the loading port (4d) of the other incubator (4) are closed, a decontamination gas is supplied to a decontamination space (S) formed on the inside of the coupling member, and a section exposed to the decontamination space is decontaminated. Efficient culturing can occur.
A decontamination operation room (30) is partitioned into a first operation room (31) and a second operation room (32). A connecting section that connects the first operation room and the second operation room can be closed. The pressure of the first operation room (31) and the second operation room (32) is adjusted by a pressure adjustment means. When the connection section is opened and the first operation room (31) and the second operation room (32) are connected, an inlet for the first operation room (31) and an outlet for the second operation room (32) are closed and air flow is generated from the second operation room (32) to the first operation room (31) by the pressure adjustment means. When carrying an article (A) into a sterilized work room (10), the article (A) is housed in the first operation room (31) and a first decontamination operation is performed, then the article (A) is transferred to the second operation room (32) and a second decontamination operation is performed.
A61L 2/20 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet utilisant des substances chimiques des substances gazeuses, p. ex. des vapeurs
The sterile work system is configured so that a worker (29) can perform sterile work on cells, etc. via gloves (28) that are provided in an isolator (15). A work headset (31) for voice output of the sterile work procedure is provided for the worker and a verification input device (39) is provided for a verifier (36). A management device (12) vocally outputs the current sterile work procedure to the work headset. When the verifier confirms that the worker has performed the current sterile work normally and this is input to the management device from the verification input device, the management device executes the next work procedure. Because the sterile work of the worker (29) can be monitored by the verifier (36), it is possible to keep incorrect work from being performed.
Beer brewing machines and structural parts and fittings therefor; brewing machines for making alcoholic beverages and structural parts and fittings therefor; automatic industrial labeling machines for applying labels to containers and bottles; food or beverage processing machines and apparatus, namely, filling machines for foods and beverages; food or beverage processing machines and apparatus, namely, bottle filling machines for foods and beverages; packaging machines; wrapping machines; loading and unloading machines; laser machines for cutting, marking, and engraving fabric designed for installation directly above embroidery machines; semiconductor manufacturing machines and parts thereof; bottling machines, namely, bottle washers, bottle fillers and bottle cappers, all sold as a unit; bottle capper machines; bottle washing machines; machines for the industrial production of pharmaceuticals, namely, vial washer, ampoule washer, syringe washer, filling/stoppering machine, freeze dryer loader and unloader, aluminum over capping machine, rubber stopper rinser, packaging handling machine, formulation machine, isolators, siliconizing unit, sheath stoppering machine, vacuum stoppering machine, sealing machine for freeze dried products, tray loader, and final packaging machine; machines for filling capsules, vials, ampoules, and suppositories; packaging machines for packaging blister cards and cartons and bottles; packaging systems consisting of several packaging machines, particularly for packaging oblong objects, namely, ampoules, small flasks and syringes for the pharmaceutical industry; machines for manufacturing packaging material such as collapsible boxes or cushioning packaging material; Industrial trash compacting machines; washing machine for industrial parts; machines for cleaning and stripping surfaces using high-speed water jet; cutting machines; vehicle washing installations; machines for blast cleaning a surface; machines for cleaning surfaces using high pressure water; organic waste processing machines, namely, waste crushing machines; agricultural machines, namely, cultivators, harvesters, disk harrows, and seeders; agricultural machines, namely, reapers Decontamination machines and apparatus to be used in the process of manufacturing of pharmaceuticals for decontamination of aseptic pharmaceutical manufacturing environments for sterilization purposes, namely, isolator systems for isolating the exterior environment or persons physically to decontaminate them and eliminate risk of pollution, which isolator systems comprised of machines and apparatus for filtering air and emitting gas, and clean rooms; decontamination machines and apparatus to be used for sterilization purposes in the process of manufacturing of pharmaceuticals, namely, sterilizers for decontamination; machines used for sterilization purposes in the process of the industrial production of pharmaceuticals
Beer brewing machines and structural parts and fittings therefor; brewing machines for making alcoholic beverages and structural parts and fittings therefor; automatic industrial labeling machines for applying labels to containers and bottles; food or beverage processing machines and apparatus, namely, filling machines for foods and beverages; food or beverage processing machines and apparatus, namely, bottle filling machines for foods and beverages; packaging machines; wrapping machines; loading and unloading machines; laser machines for cutting, marking, and engraving fabric designed for installation directly above embroidery machines; semiconductor manufacturing machines and parts thereof; bottling machines, namely, bottle washers, bottle fillers and bottle cappers, all sold as a unit; bottle capper machines; bottle washing machines; machines for the industrial production of pharmaceuticals, namely, vial washer, ampoule washer, syringe washer, filling/stoppering machine, freeze dryer loader and unloader, aluminum over capping machine, rubber stopper rinser, packaging handling machine, formulation machine, isolators, siliconizing unit, sheath stoppering machine, vacuum stoppering machine, sealing machine for freeze dried products, tray loader, and final packaging machine; machines for filling capsules, vials, ampoules, and suppositories; packaging machines for packaging blister cards and cartons and bottles; packaging systems consisting of several packaging machines, particularly for packaging oblong objects, namely, ampoules, small flasks and syringes for the pharmaceutical industry; machines for manufacturing packaging material such as collapsible boxes or cushioning packaging material; Industrial trash compacting machines; washing machine for industrial parts; machines for cleaning and stripping surfaces using high-speed water jet; cutting machines; vehicle washing installations; machines for blast cleaning a surface; machines for cleaning surfaces using high pressure water; organic waste processing machines, namely, waste crushing machines; agricultural machines, namely, cultivators, harvesters, disk harrows, and seeders; agricultural machines, namely, reapers Decontamination machines and apparatus to be used in the process of manufacturing of pharmaceuticals for decontamination of aseptic pharmaceutical manufacturing environments for sterilization purposes, namely, isolator systems for isolating the exterior environment or persons physically to decontaminate them and eliminate risk of pollution, which isolator systems comprised of machines and apparatus for filtering air and emitting gas, and clean rooms; decontamination machines and apparatus to be used for sterilization purposes in the process of manufacturing of pharmaceuticals, namely, sterilizers for decontamination; machines used for sterilization purposes in the process of the industrial production of pharmaceuticals
Sterilization units for medical instruments; sterilized gas generators for medical instruments Sterilizers not for medical purposes; sterilized gas generators not for medical purposes
