In one approach, quantitative ultrasound imaging is altered to account for the effects of intervening tissue. The tissue layers between the transducer and the region are measured, and the measurement is input to a machine-learned model to quantify from signals for a region of interest and the measurement. This may provide more accurate quantification. In another approach, the region of interest (ROI) is automatically placed, such as through detection of anatomy (e.g., liver capsule), identification of and/or guidance to the field of view, and/or scoring of imaging of the anatomy. This ROI placement may avoid variability in quantification.
In a chip-on-array approach, acoustic and electronic modules are separately formed. The acoustic stack is connected to one interposer, and the electronics are connected to another interposer. Different connection processes (e.g., using low temperature bonding for the acoustic stack and higher temperature-based interconnect for the electronics) may be used. This arrangement may allow for different pitches of the transducer elements and the I/O of the electronics by staggering vias in the interposers. The two interposers are then connected to form the chip-on-array.
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
G01S 7/52 - Détails des systèmes correspondant aux groupes , , de systèmes selon le groupe
G01S 15/89 - Systèmes sonar, spécialement adaptés à des applications spécifiques pour la cartographie ou la représentation
H10N 30/05 - Fabrication de dispositifs piézo-électriques ou électrostrictifs multicouches ou de leurs parties constitutives, p. ex. en empilant des corps piézo-électriques et des électrodes
H10N 30/071 - Montage de parties piézo-électriques ou électrostrictives avec des éléments semi-conducteurs ou avec d’autres éléments de circuit sur un substrat commun
H10N 30/088 - Mise en forme ou usinage de corps piézo-électriques ou électrostrictifs par usinage par coupe ou découpage en dés
H10N 30/30 - Dispositifs piézo-électriques ou électrostrictifs à entrée mécanique et sortie électrique, p. ex. fonctionnant comme générateurs ou comme capteurs
H10N 30/50 - Dispositifs piézo-électriques ou électrostrictifs avec une structure empilée ou multicouche
H10N 30/87 - Électrodes ou interconnexions, p. ex. connexions électriques ou bornes
A system includes a gamma ray collimator including a plurality of collimator elements, each of the plurality of collimator elements associated with a respective set of image formation characteristics, wherein a first one of the plurality of collimator elements is removable from the collimator.
G21K 1/02 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant des diaphragmes, des collimateurs
G01T 1/161 - Applications au domaine de la médecine nucléaire, p. ex. comptage in vivo
Disclosed herein is a device for manufacturing a scintillator comprising a furnace that includes a furnace wall; a crucible with a shelf disposed on an outer periphery of the crucible; where the shelf comprises a channel that is operative to hold a molten material and deliver the molten material to the crucible through a porous wall; a first delivery arrangement that is operative to deliver a scintillation material precursor to the shelf; a second delivery arrangement that is operative to deliver a dopant precursor directly to the crucible; where the scintillation material precursor and the dopant precursor do not contact each other prior to being delivered to the crucible; and a heating coil disposed inside the furnace wall and outside both the crucible and the shelf; where the scintillation material precursor and the dopant precursor are melted via resistance heating of the crucible and the shelf.
In emission imaging, one, two, or a few topograms without a full CT scan are used to localize, such as through triangulation, and/or generate an attenuation map, such as based on model fitting. A limited radiation exposure, rather than a longer, larger full CT exposure, is needed to localize and/or provide attenuation correction for emission imaging, such as cardiac SPECT imaging.
Systems and methods for detecting subject motion within medical images based on trained deep learning processes are disclosed. In some examples, an image processing system receives positron emission tomography (PET) measurement data and co-modality measurement data from an image scanner. The image processing system generates PET images and co-modality images based on the PET measurement data and co-modality measurement data, respectively. Further, the image processing system inputs the PET images and the co-modality images to a first trained neural network, and generates first features of the PET measurement data and second features of the co-modality measurement data. The image processing system inputs the first features and the second features to a second trained neural network and, generates displacement data characterizing a displacement between the first features and the second features. Based on the displacement data, the image processing system generates display data for display.
G06F 3/14 - Sortie numérique vers un dispositif de visualisation
G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
An ultrasound modular front-end framework. An ultrasound modular front-end includes
a first ultrasound front-end circuit that generates digital ultrasound data, and a communication module that is configured to be communicatively coupled to an ultrasound probe and a main console. The main console constructs ultrasound images based on the digital ultrasound data. The ultrasound front-end circuit is disposed within a housing that is separate from a housing of the main console.
A method of identifying prompt gamma rays by triple-photon detection is disclosed. The method involves using two annihilation photons and a prompt gamma photon to determine the direction of the corresponding prompt gamma ray.
Systems and methods for optimizing an electro-anatomical model of an anatomical object of a patient are provided. 1) one or more input medical images of an anatomical object of a patient and 2) electrophysiological data associated with the anatomical object are received. An electro-anatomical model of the anatomical object is generated based on the one or more input medical images and the electrophysiological data. The electro-anatomical model is optimized based on one or more electrical conduction parameters for electrical pathways in the electro-anatomical model. The one or more electrical conduction parameters are continuous variables defined between a value representing no electrical conduction in the electrical pathways and a value representing full electrical conduction in the electrical pathways. The optimized electro-anatomical model is output.
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
A61B 5/319 - Circuits de simulation de signaux ECG
Systems and methods include acquisition of a computed tomography image of an object, determination of a linear attenuation coefficient map based on the computed tomography image, acquisition of positron emission tomography (PET) data of the object, determination of a histoimage of the object based on the PET data, determination of a scatter histoimage based on the histoimage and the linear attenuation coefficient map, determination of a scatter-corrected histoimage based on the histoimage and the scatter histoimage, and input of the computed tomography image and the scatter-corrected histoimage to a trained neural network to generate a PET image.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
Systems and methods for detecting multiple events during nuclear imaging scans, and for reconstructing images based on the detected events, are disclosed. In some embodiments, an image scanning system scans a subject, and generates a signal characterizing a detection event. The system applies a peak detection process to the signal and, based on the application of the peak detection process, detects a position of each of a plurality of peaks of the signal. Further, the system determines an amplitude of each of the peaks of the signal. The system also determines an energy value for each of the peaks based on applying a curve fitting process to the position and the amplitude of each of the peaks. The system may also determine a time-offset value for a peak based on its position in relation to a previous peak, and may transmit the energy values and corresponding times to generate time-coincident pairs for image reconstruction.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
12.
METHODS AND APPARATUS FOR MACHINE LEARNING BASED MEDICAL IMAGING EVENT DETECTION AND IMAGE RECONSTRUCTION
Systems and methods for detecting multiple events during nuclear imaging scans, and for reconstructing images based on the detected events, are disclosed. In some embodiments, an image scanning system scans a subject, and generates a signal characterizing a detection event. The system generates sampled data based on sampling the at least one signal. Further, the system applies a trained machine learning process to the sampled data. Based on the application of the trained machine learning process, the system generates pulse data characterizing a plurality of decoupled pulses. For example, the pulse data may characterize pulse energy values of each of the decoupled pulses, and corresponding times for each of the pulses. Further, the method includes transmitting the pulse data to generate time-coincident pairs for image reconstruction.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
13.
SYSTEMS AND METHODS FOR SUPER TIME-OF-FLIGHT RESOLUTION
Systems and methods of generating improved resolution histo-images are disclosed. A system includes a positron emission tomography (PET) imaging modality configured to execute a first scan to acquire a first PET dataset and a processor configured to back-project the first PET dataset to generate a first histo-image having a first resolution, input the first histo-image to a trained neural network, receive a second histo-image from the trained neural network, and input the second histo-image to a reconstruction process configured to generate a reconstructed PET image. The second histo-image has a second resolution higher than the first resolution. The second histo-image represents the first PET dataset.
G06T 3/4046 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement utilisant des réseaux neuronaux
G06T 3/4053 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement basé sur la super-résolution, c.-à-d. où la résolution de l’image obtenue est plus élevée que la résolution du capteur
14.
Artificial Intelligence-Assisted Contouring in Medical Imaging
For AI-assisted segmentation, when a user alters a segmentation of an object, indications of what is not desired (e.g., samples from where the segmentation border use to be but is no longer due to the change) are used to inform segmentation for non-changed regions. Negative and positive samples from a user alteration may be extracted. Information from these negative, with or without the positive samples, is used by a machine-learned model to re-segment the object. The user change is used to correct the segmentation even for non-changed regions, minimizing the amount of manual adjustment needed and providing segmentation specific to the user and/or purpose.
A framework for energy-resolved image reconstruction. The framework receives projection data representing emissions detected from a subject. The projection data may be formatted into energy-resolved data. Contribution coefficients of one or more components of the emissions may be determined based on the energy-resolved data. An image of the subject may be reconstructed using the contribution coefficients.
A framework for natural language processing for medical imaging. The framework may first receive a user request the includes natural language text. One or more imaging parameters may be generated in response to the user request using a trained large language model. A medical imaging task may be initiated based on the one or more imaging parameters. A response may then be generated based on results of the medical imaging task.
For cardiac flow detection in echocardiography, by detecting one or more valves, sampling planes or flow regions spaced from the valve and/or based on multiple valves are identified. A confidence of the detection may be used to indicate confidence of calculated quantities and/or to place the sampling planes.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
A cooling system for a medical imaging apparatus. The cooling system may include mounting rails circumferentially spaced on a backplane of a gantry of the medical imaging apparatus. Cooling structures may be slidably mounted on the mounting rails. At least one of the cooling structures includes a chill plate, at least one detector electronics assembly (DEA) thermally conductively coupled to the chill plate, and a cooling conduit thermally conductively coupled to the chill plate, wherein the cooling conduit receives a fluid coolant via a first connection and discharges the fluid coolant via a second connection.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
19.
ELECTROMAGNETIC INTERFERENCE (EMI) SHIELDING END CAP FOR AN EMI SHIELDING HOUSING
An enclosure for shielding electromagnetic interference (EMI). The enclosure includes an EMI shielding housing having a plurality of walls and at least one open end, wherein the walls define an internal cavity and wherein an inner surface of at least one wall includes an electrically conductive edge section located at the open end. The enclosure also includes an end cap that is removably attached to the open end, an electrically conductive foil element having a wiper contact and a resilient and electrically conductive EMI gasket located between the end cap and the foil element. The wiper contact and EMI gasket are folded such that the wiper contact is located between the EMI gasket and the edge section wherein the wiper contact makes electrical contact with the edge section and the EMI gasket is biased to push the wiper contact toward the edge section to maintain electrical contact.
H01R 13/6584 - Structure du blindage avec des moyens élastiques destinés à venir en contact avec le connecteur correspondant avec des organes élastiques conducteurs indépendants entre les organes de blindage correspondants formés par des organes élastomères conducteurs, p. ex. des joints plats ou des joints toriques
H01R 13/6582 - Structure du blindage avec des moyens élastiques destinés à venir en contact avec le connecteur correspondant
H01R 13/6583 - Structure du blindage avec des moyens élastiques destinés à venir en contact avec le connecteur correspondant avec des organes élastiques conducteurs indépendants entre les organes de blindage correspondants
G12B 17/02 - Écrans contre les champs électriques ou magnétiques, p. ex. ondes radio
20.
THREE DIMENSIONAL ORGAN RECONSTRUCTION FROM TWO DIMENSIONAL SPARSE IMAGING DATA
Systems and methods for three dimensional reconstruction from two dimensional imaging data. An neural implicit shape function model is used to regress a shape of an organ from two dimensional sparse imaging data. Contours of the organ are generated from the two dimensional sparse imaging data. The contours are used to train the neural implicit shape function model to regress the shape of the organ.
Acoustic absorbers are formed for ultrasound transducers. The acoustic absorber provides desired attenuation, impedance, and thermal conductivity qualities based on a filler of rubber, ceramic, and metal particles. The relative amounts of the different fillers may be adjusted to tune the acoustic attenuation, thermal conductivity, and/or acoustic impedance.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
B06B 1/06 - Procédés ou appareils pour produire des vibrations mécaniques de fréquence infrasonore, sonore ou ultrasonore utilisant l'énergie électrique fonctionnant par effet piézo-électrique ou par électrostriction
Systems and methods for correcting timing information associated with captured nuclear imaging data, and for reconstructing medical images based on the corrected timing information, are disclosed. In some embodiments, an image scanning system scans a subject, detects an event, and generates timing data for the detected event. The timing data includes a first number of bits, and characterizes a time that a crystal of the image scanning system detected the event. The image scanning system shifts the first number of bits by a predetermined amount to generate a second number of bits, where the second number of bits includes at least one bit representing a lower order time value than the least significant bit of the first number of bits of the timing data. Further, the image scanning system generates timing correction data for the event based on the second timing data.
Systems and methods include determination of an anatomical image of an object, input of the anatomical image to a trained neural network to generate a synthetic functional image, acquisition of molecular imaging data of the object based on acquisition parameters, reconstruction of a functional image based on the molecular imaging data, determination of a difference between the functional image and the synthetic functional image, change of one of the acquisition parameters based on the difference, acquisition of second molecular imaging data of the object based on the changed acquisition parameters, and reconstruction of a second functional image based on the second molecular imaging data.
Disclosed herein is a device for manufacturing a single crystal comprising: a furnace that includes a furnace wall; a crucible disposed on a first base plate within the furnace; where the first base plate has a porosity of 1 to 80 volume percent, based on a total volume of the first base plate; and where the first base plate does not comprise free flowing particles; an induction coil disposed inside the furnace wall and outside the crucible; and a refractory lining being disposed in an annulus between the furnace wall and the crucible.
Systems and methods include acquisition of an anatomical image of an object, acquisition of molecular imaging data of the object at the plurality of photon detectors, reconstruction of a functional image based on the molecular imaging data, input of the anatomical image and the functional image to a trained neural network to generate a second functional image, and presentation of the second functional image.
A patient handling system (PHS) for a medical imaging system having a tunnel that extends through at least one scanning portion of the system. The PHS includes a first moveable pedestal that supports a detachable first pallet that includes a first patient. The first pedestal moves the first pallet through the tunnel to enable scanning of the first patient. The PHS also includes a second moveable pedestal located at a tunnel exit. The second pedestal attaches to the first pallet as the first pallet moves through the tunnel and the first pedestal subsequently detaches from the first pallet. The second pedestal then moves away from the tunnel exit to remove the first pallet from the tunnel. A second patient to be scanned is simultaneously prepared for scanning on a second pallet as the first pallet is moved through the tunnel in order to increase patient throughput through system.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A framework for aligning images from a multi-modality imaging system. A first image of a phantom positioned on a patient table may be acquired using a first camera of first modality in the multi-modality imaging system. The phantom may include first and second hot rods, as well as first, second and third cold rods. The first and second hot rods are disposed in a plane that is substantially orthogonal to a travel vector of the patient table, while the first and second cold rods are substantially orthogonal to the travel vector, and the third cold rod is substantially parallel to the travel vector. A second image of the phantom may be acquired using a second camera of second modality in the multi-modality imaging system. Misalignment parameters of the first and second cameras may be determined based on the first and second images.
A system to scan a region of a patient comprises determination of the region, acquisition of PET singles data from a plurality of photosensors, determination of PET singles data which is associated with the region, generation of PET coincidence data based on the PET singles data which is associated with the region, and generation of a PET image based on the PET coincidence data.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A system and method includes acquisition of nuclear imaging data, reconstruction of a three-dimensional image based on nuclear imaging data, input of the three-dimensional image to a trained convolutional network to either generate a linear attenuation correction map and a simulated computed tomography image based on the linear attenuation correction map or generate simulated computer tomography images directly, application of a segmentation algorithm to the simulated computed tomography image to generate a segmentation map, and display of the segmentation map.
For movement of medical sensors for medical imaging, an artificial intelligence (AI) is trained using a contrastive reinforcement learning (CRL) framework. Simulation may be used to provide the training data. For training, the sampling for a given input instance in CRL may use trajectories simulated from different patients for better contrast. CRL, with or without the simulation feature and/or the sampling feature, may provide more generalized navigation, such as in interventional or diagnostic settings.
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
Machine learning based systems and methods for improving attenuation and scatter correction and for estimating organ volume in medical images are disclosed. In some embodiments, a co-modality image, a non-attenuated corrected nuclear image, and an x-ray image are received. A first machine learning process is applied to the co-modality image to generate location data identifying feature locations. Further, a second machine learning process is applied to the non-attenuated corrected nuclear image, the x-ray image, and the location data to generate a segmentation mask. In addition, at least a third machine learning process is applied to the segmentation mask, the co-modality image, the non-attenuated corrected nuclear image, and the x-ray image to generate a plurality of synthetic images. Moreover, at least a fourth machine learning process is applied to the plurality of synthetic images to generate a final synthetic image.
G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
32.
UNINTERRUPTED COOLING SYSTEM FOR A DIAGNOSTIC MEDICAL IMAGING APPARATUS
A passive, uninterrupted cooling system continues to absorb waste heat generated with a diagnostic medical imaging system during a patient scan, in the event of a power failure incident or disruption of cooling water supply within an imaging facility. The passive, uninterrupted cooling system incorporates one or more phase change materials (PCMs) that maintain the cooling system temperature at material's melting temperature, while absorbing the imaging system's waste heat. This enables clinicians to complete an in-progress imaging scan of a patient within the scanning system's operational temperature specifications. In some embodiments, the PCMs absorb transient heat spikes generated during patient scans, in order to maintain a relatively consistent cooling system operational temperature. In some embodiments, the passive, uninterrupted cooling system is used to cool PET/CT, PET, or CT imaging systems.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A Positron Emission Tomography (PET) detector includes a sensor. The sensor includes a photodetector array, an anode summing circuit, a cathode summing circuit, and a processor. The photodetector array has a plurality of photodetectors arranged in a two-dimensional grid having rows and columns, each photodetector configured to generate an anode signal and a cathode signal in response to an event at the photodetector. The anode summing circuit is configured to determine a sum of anode currents generated by photodetectors within a column of the photodetector array. The cathode summing circuit is configured to determine a sum of cathode currents generated by photodetectors within a row of the photodetector array. The processor is configured to determine parameters of the event based on at least one of the sum of anode currents and the sum of cathode currents.
A threading machine performs a method for creating a continuous loop of twine. A plate has a first face, a second face opposite the first face, and a hole therethrough. A ring gear is disposed on the first face and rotates about a central axis aligned with the hole. A drive pulley unwinds the thread from a spool on the ring gear and through the central axis of the ring gear in a threading direction. The drive pulley directs the thread through the ring gear a plurality of times. The ring gear is held stationary as the drive pulley unwinds the thread during a first manufacturing step to form a core of the continuous loop and rotates as the drive pulley unwinds the thread during a second manufacturing step to wrap the thread around the core to form an outer wrap around the core.
Systems and methods that employ machine learning processes for generating medical images associated with a particular uptake time. For instance, the embodiments may apply machine learning processes to positron emission tomography (PET) images captured with a first uptake time to generate output images associated with a second uptake time. In some examples, a system receives PET measurement data characterizing a scanned image of a subject. The system also receives uptake time data characterizing a first uptake time of the scanned image. The system applies a trained machine learning process to the measurement data and the uptake time data and, based on the application of the trained machine learning process to the measurement data and the uptake time data, generates output image data characterizing an output image at a second uptake time. The second uptake time may be greater than the first uptake time of the originally captured PET images.
G06T 11/60 - Édition de figures et de texteCombinaison de figures ou de texte
G06V 10/771 - Sélection de caractéristiques, p. ex. sélection des caractéristiques représentatives à partir d’un espace multidimensionnel de caractéristiques
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
For robotically operating multiple catheters, a common interface is used for control of two or more different catheter robotics systems. Information is used from one catheter robotic system for control of the other robotic catheter system. The common interface provides for collaborative control. Since different robotic systems may be used for different catheters, the common interface allows for the same user input and control to be translated for robotic control using any of various catheters.
For emission tomography, a greater number of emissions are detected. To detect a greater number of emissions and provide better resolution than provided by a parallel hole collimator, the collimator is replaced by an attenuation object with exterior and interior edges. Rather than enforcing directionality, larger holes with different shapes may be used to allow a greater number of emissions to be detected. By moving the attenuation object, the differences in the shadows on the sensor may be used as a time-encoded aperture to reconstruct the source of emissions with greater resolution and sensitivity than where a fixed parallel hole collimator is used.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
38.
DISPLACEMENT MECHANISM FOR PATIENT CONTROLLED PLACEMENT AND REMOVAL OF AN OPTICAL DEVICE IN A CONFINED SPACE ENVIRONMENT
A method of placing an optical device onto a patient's eyes and removing the optical device from the patient's eyes when the patient is located in a patient bore of a medical imaging system having a confined headspace. The method includes providing a pneumatic device and a resilient element attached between an inner surface of the patient bore and the optical device wherein the resilient element extends through the pneumatic device and wherein the optical device is spaced apart from the patient's eyes in a first position. The pneumatic device is inflated to move the optical device to a second position wherein the optical device is placed on the patient's eyes. Inflation of the pneumatic device extends the resilient element and biases the resilient element to return to the first position. Air is vented from the pneumatic device to return the optical device to the first position.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
For predictive control of tendon-driven continuum mechanisms (TDCMs), a machine-learned model predicts future control of the motor or robot based on user commands to move the catheter. For example, a robotically operated catheter includes a TDCM. The machine-learned model, such as a recurrent neural network or another artificial intelligence, predicts future control. This prediction may account for the unknown environment using input of past states of the motor and/or position of the tip of the catheter or other steered device.
Systems and methods for real time three-dimensional left atrial appendage (LAA) quantification. Deep learning is used to perform LAA segmentation, tracking and live quantification on critical measurement in 4D ultrasound sequences. The collected information may be used for device selection and anomaly detection to assist early-phase disease finding.
For single photon emission computed tomography (SPECT) detectors, an embedded capacitance material (ECM) is used in a printed circuit board (PCB) with the semiconductor detector. The high voltage (HV) filtering and/or blocking capacitors are formed from ECM. The ECM interferes less with the radiation or emissions to be detected by the semiconductor detector than a surface mounted capacitor
G01T 1/24 - Mesure de l'intensité de radiation avec des détecteurs à semi-conducteurs
H05K 1/18 - Circuits imprimés associés structurellement à des composants électriques non imprimés
H05K 1/16 - Circuits imprimés comprenant des composants électriques imprimés incorporés, p. ex. une résistance, un condensateur, une inductance imprimés
42.
USE OF BACKGROUND RADIATION-BASED TOF OFFSETS TO EVALUATE ANNIHILATION RADIATION-BASED TOF OFFSETS
Systems and methods include determination of a first time-of-flight offset for each of a plurality of crystals based on first annihilation radiation received by the plurality of crystals, determination of a second time-of-flight offset for each of the plurality of crystals based on radiation emitted by the plurality of crystals, determination, based on the second time-of-flight offsets, of a third time-of-flight offset for each of the plurality of crystals and associated with a response of the plurality of crystals to annihilation radiation, determination of whether the third time-of-flight offsets exceed a threshold, and, in response to a determination that the third time-of-flight offsets exceed the threshold, determine a fourth time-of-flight offset for each of the plurality of crystals based on second annihilation radiation received by the plurality of crystals.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
G01T 7/00 - Détails des instruments de mesure des radiations
43.
LESION LINKING USING ADAPTIVE SEARCH AND A SYSTEM FOR IMPLEMENTING THE SAME
Disclosed herein is a system for linking images of a lesion taken over different periods of time comprising an imaging device that is operative to image one or more lesions present in a living being. The imaging device takes a first image at a first point in time T1 and a second image at a second point in time T2. A microprocessor is operative to receive the first image and the second image and to perform an adaptive search on the respective images. The adaptive search comprises selecting a first voxel in a first lesion in the first image and radially searching for one or more second lesions in the second image that share one or more overlapping first voxels with the first lesion in the first image. A probability is assigned if there is an overlap between the first lesion and one or more second lesions. Each voxel in the first lesion based on the probability.
Systems and methods include acquisition of positron emission tomography (PET) data of a volume comprising blood and tissue, determination, from the acquired PET data, of a blood input function (BIF) from a time at which non-metabolized radionuclide tracer within the volume has reached a steady state between the blood and the tissue, and determination of parametric images based on the acquired PET data, the determined BIF and a parametric model which does not include BIF values prior to the time.
In one approach for surgical guidance with compounded ultrasound imaging, a neural field uses both probe tracking and ultrasound imaging to compound the ultrasound data into three-dimensions with alignment of the component fields of view. Accurate compounding is provided, and the compounding may operate in real-time. In another approach for visualization with pre-operative data, modeling (e.g., the neural field) from ultrasound is used to generate a 3D deformation field, which is then applied to the pre-operative data. The 3D deformation field may be applied in rendering rather than to the pre-operative volume dataset. This 3D deformation may be used in real-time, allowing for synchronized 3D ultrasound and 3D pre-operative imaging.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
The Trustees of The University of Pennsylvania (USA)
Inventeur(s)
Millardet, Mael
Matej, Samuel
Bharkhada, Deepak
Panin, Vladimir
Schaefferkoetter, Joshua
Abrégé
Systems and methods for reconstructing medical images based on the trained deep learning processes, and for training deep learning processes, are disclosed. In some examples, image measurement data is received. A histo-image is generated based on the image measurement data. Further, an attenuation map, such as a μ-map, is received. An attenuation histo-image is generated based on the attenuation map. Further, a trained machine learning process, such as a trained neural network, is applied to features generated from the histo-image and the attenuation histo-image. Based on the application of the machine learning process to the histo-image and the attenuation histo-image, output image data characterizing an image volume is generated. In some examples, a machine learning process is trained based on histo-images and corresponding attenuation histo-images. The trained machine learning process may be employed to reconstruct images, such as positron emission tomography (PET) images.
A Positron Emission Tomography system includes a circuit for a detector of the system. The detector includes an array of silicon photomultipliers. The circuit includes the array of silicon photomultipliers, an amplifier, and a transformer between the amplifier and the array of silicon photomultipliers. The array of silicon photomultipliers is connected between a first end of the transformer and a second end of the transformer. The array includes at least two silicon photomultipliers connected in series.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
48.
METHODS AND APPARATUS FOR DEEP LEARNING BASED IMAGE ALIGNMENT FOR IMAGE RECONSTRUCTION
Systems and methods for reconstructing medical images based on motion estimation are disclosed. Measurement data from positron emission tomography (PET) measurement data, and modality measurement data from an anatomy modality, such as computed tomography (CT) data, is received from an image scanning system. A trained deep learning process is applied to the PET measurement data and the modality measurement data to generate displacement vector field (DVF) data characterizing motion between the PET measurement data and the modality measurement data. A modality image is reconstructed from the modality measurement data, and the modality image is adjusted based on the DVF data. A PET image is then reconstructed from the PET measurement data and the adjusted modality image, and the PET image is adjusted based on a computed inverse of the DVF data. The adjusted PET image and the modality image spatially match, and are displayed.
The Trustees of The University of Pennsylvania (USA)
Inventeur(s)
Bharkhada, Deepak
Panin, Vladimir
Millardet, Mael
Abrégé
Systems and methods for training end-to-end deep learning reconstruction processes, and for reconstructing medical images based on the trained deep learning processes, are disclosed. In some examples, input projection data is received. An untrained machine learning process is applied to the input projection data and, based on the application of the machine learning process to the projection data, an output image is generated. Further, a forward projection process is applied to the output image and, based on the application of the forward projection process to the output image, forward projected image data is generated. A loss value is then determined based on the forward projected image data and the input projection data. The loss value is then compared to a threshold value to determine whether the machine learning process is trained. The trained machine learning process may be employed to reconstruct images, such as positron emission tomography (PET) images.
Provided is a data driven approach for identifying the motion-free (or quiescent) period for imaging the heart. This timing information is not readily available from a conventional electrocardiogram (ECG) trace. The method identifies the motion-free period on a beat-by-beat basis.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 5/113 - Mesure du mouvement du corps entier ou de parties de celui-ci, p. ex. tremblement de la tête ou des mains ou mobilité d'un membre se produisant au cours de la respiration
A61B 6/50 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des parties du corps spécifiquesAppareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations spécialement adaptés à des applications cliniques spécifiques
A framework for scheduling nuclear medicine scanning. The framework may search a database for a patient record of a previous patient that is most similar to a current patient based on first patient and scan attributes associated with the current patient. The patient record of the most similar patient includes second patient and scan attributes. In response to the first scan procedure associated with the current patient matching the second scan procedure of the patient record, a scan duration may be predicted based on the patient record to generate a predicted scan duration for the current patient.
G16H 40/20 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour la gestion ou l’administration de ressources ou d’établissements de soins de santé, p. ex. pour la gestion du personnel hospitalier ou de salles d’opération
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 50/70 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour extraire des données médicales, p. ex. pour analyser les cas antérieurs d’autres patients
52.
METHODS AND APPARATUS FOR MULTI-SPATIAL GUIDED IMAGE RECONSTRUCTION
Systems and methods for reconstructing medical images are disclosed. Measurement data from positron emission tomography (PET) data, and measurement data from an anatomy modality, such as magnetic resonance (MR) data, is received from an image scanning system. A PET image is generated based on the PET measurement data, and a plurality of anatomy images are generated based on the anatomy measurement data. The plurality of anatomy images include voxels of differing spatial resolutions. A multi-spatial image reconstruction process is applied to the PET measurement data and the plurality of anatomy images. Based on the application of the image reconstruction process, image volume data characterizing a reconstructed medical image is generated. The reconstructed medical image may be displayed to a medical professional for diagnosis.
The power supply in ultrasound imaging includes a switched capacitance. The capacitance is switched on to provide power during generation of pushing pulses for elasticity imaging and is switched off during other modes of imaging.
A gantry tube for a magnetic resonance/positron emission tomography imaging system. The gantry tube includes a first tube located within a second tube, wherein the first tube is oriented about a longitudinal axis of the system. The gantry tube also includes a plurality of wall elements that extend between the first and second tubes, wherein the walls and first and second tubes form a plurality of channels that extend in an axial direction substantially parallel to the longitudinal axis wherein each channel is configured to hold a PET detector of the imaging system. A PET detector is inserted into or removed from an associated channel in an axial direction from either a first end or a second end of the gantry tube.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
For view-dependent control, different desired imaging catheter views are defined. A robotic catheter system may alter from one view to another view based on activation but otherwise hands-free by the operator. This pre-definition of views and swapping views intra-operatively provides procedure monitoring information while avoiding radiation and minimizing interruption of the procedure (e.g., needle placement and puncture).
A61M 25/01 - Introduction, guidage, avance, mise en place ou maintien en position des cathéters
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
A61B 34/10 - Planification, simulation ou modélisation assistées par ordinateur d’opérations chirurgicales
Systems and methods for segmenting one or more lesions from medical image patches are provided. An input medical image patch depicting one or more lesions is received. The one or more lesions are segmented from the input medical image patch using a plurality of machine learning based segmentation networks to respectively generate a plurality of initial segmentation masks. Each of the plurality of machine learning based segmentation networks is trained to segment lesions from patches with a different field of view size. A final segmentation mask of the one or more lesions is generated based on the plurality of initial segmentation masks. The final segmentation mask of the one or more lesions is output.
For robust view classification and measurement estimation in sequential ultrasound imaging, the classification and/or measurements for a given image or sequence of images are gated. To prevent oscillation in results, the gating provides consistent output.
Systems and methods for converting medical imaging metadata from a first format to a second format are provided. Medical imaging metadata in a first format and instructions are received. The medical imaging metadata is converted from the first format to a second format based on the instructions using a machine learning based model. The medical imaging metadata in the second format is output.
G16H 30/40 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le traitement d’images médicales, p. ex. l’édition
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
For SPECT reconstruction, zonal reconstruction is provided intra-modally. Rather than or in addition to using CT for structure, SPECT data from one energy may be used to provide structural information or zones for another energy. The zonal reconstruction may be combined with model-based multi-energy image formation. Multi-spectral, zonal reconstruction is used as an intra-modal imaging approach.
A framework for calibrating activity concentration uptake. The framework generates a pattern that represents a volume of interest. A three-dimensional (3D) phantom may be printed based on the pattern. Activity concentration uptake in the volume of interest may then be calibrated by using the 3D phantom.
A framework for distributed medical image acquisition. An optimal configuration of one or more mobile imaging systems to address a clinical task is determined. The one or more mobile imaging systems may be dispatched in accordance with the optimal configuration to perform medical image acquisition of a patient to generate medical image data. Image reconstruction may then be performed based on the medical image data.
A system to scan a region of a patient comprises performance of a positron emission tomography (PET) scan using a PET imaging system to acquire raw PET data comprising a plurality of coincidence events, the raw PET data comprising a first one or more portions corresponding to the region and a second one or more portions not corresponding to the region, determination of the first one or more portions corresponding to the region, and reconstruction of the raw PET data into a PET image of the region using only the first one or more portions of the raw PET data corresponding to the region.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
An imaging system comprising a magnetic resonance imaging system with a gradient coil (3) arrangement configured to produce a varying magnetic gradient field during operation, the medical imaging system comprising one or several printed circuit boards arranged such that they are within the magnetic gradient field of the magnetic resonance imaging system during operation, each circuit board having at least one conducting layer (6), in particular a copper layer, wherein at least one of the circuit boards comprises a mesh (7) of holes that spreads over at least a partial region of the conducting layer (6).
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 5/055 - Détection, mesure ou enregistrement pour établir un diagnostic au moyen de courants électriques ou de champs magnétiquesMesure utilisant des micro-ondes ou des ondes radio faisant intervenir la résonance magnétique nucléaire [RMN] ou électronique [RME], p. ex. formation d'images par résonance magnétique
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
For correction of motion in single photon emission computed tomography (SPECT) imaging, extra modal information is used to delineate different regions in a patient. Motion in these different regions as reflected in SPECT data is determined. These regional motions are used for motion correction. Statistical measurements for the SPECT data of the different regions may be used to weight the regional motions.
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
65.
IMAGE CLASSIFICATION-DEPENDENT USER INTERFACE IN ULTRASOUND IMAGING
For a classification-dependent user interface in ultrasound imaging with an ultrasound scanner, the ultrasound scanner classifies a view represented in an image. The user interface changes according to the view, allowing one or a few user inputs to be used for different user options or behavior combinations appropriate for the classified anatomy. The context from imaging alters the behavior of a given user input element of the user interface.
G06V 10/25 - Détermination d’une région d’intérêt [ROI] ou d’un volume d’intérêt [VOI]
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
Systems and methods to estimate mean randoms include acquisition of list mode data describing true coincidences and delay coincidences detected during a scan of an object, determination of a plurality of time periods of the scan based on a distance moved by a bed supporting the object during each of the plurality of time periods, determination, for each crystal and for each of time period, of delay coincidences including the crystal based on the list mode data, determination, for each crystal, of a singles rate associated with each time period based on the delay coincidences determined for the crystal over the time period, determination, for each time period, of estimated mean randoms for each crystal pair based on the singles rate associated with the time period, and reconstruction of an image of the object based on the estimated mean randoms for each time period and the detected true coincidences.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
G01T 1/36 - Mesure de la distribution spectrale des rayons X ou d'une radiation nucléaire
A patient handling systems (PHS) for medical imaging apparatus positions a patient on a patient bed in and out of an imaging field of view. A trolley carrying the patient bed translates linearly on a frame. The weight load of the patient bed is transferred to the frame along a load direction. The system incorporates a linear motor, having a rotor coupled to the trolley and a linear stator coupled to the frame in mutually opposed orientation, separated by a motor gap. The system also incorporates a linear motion encoder, having a sensing head coupled to the trolley and a linear encoder tape coupled to the frame in mutually opposed orientation, separated by a sensor gap. Both the motor and sensor gaps are oriented parallel to the weight load direction, to reduce likelihood of either gap variation attributable to load deflection of the frame.
A system for synthesizing medical images including synthesizing medical abnormalities has multiple diffusion model based denoising stages. At a first denoising stage, a machine-learned network denoises a first noise input to obtain an abnormality spatial mask detailing positional and structural characteristics of the synthesized medical abnormality. At a second denoising stage, a machine-learned network denoises a second noise input based on the abnormality spatial mask and a pre-abnormality image to obtain a synthesized medical image that corresponds to the pre-abnormality image with the synthesized medical abnormality inserted consistent with the abnormality spatial mask.
G16H 30/20 - TIC spécialement adaptées au maniement ou au traitement d’images médicales pour le maniement d’images médicales, p. ex. DICOM, HL7 ou PACS
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
A framework for continuously monitored remote power shutdown. In accordance with one aspect, a monitoring circuit is coupled to a power removal circuit. The monitoring includes an impedance device and a current detection device coupled to the impedance device. The current detection device generates an output signal indicative of circuit integrity of the power removal circuit.
H02H 3/08 - Circuits de protection de sécurité pour déconnexion automatique due directement à un changement indésirable des conditions électriques normales de travail avec ou sans reconnexion sensibles à une surcharge
H02H 1/00 - Détails de circuits de protection de sécurité
70.
DEEP LEARNING FOR REGISTERING ANATOMICAL TO FUNCTIONAL IMAGES
A framework for registering anatomical to functional images using deep learning. In accordance with one aspect, the framework extracts features by applying an anatomical image and a corresponding functional image as input to a first trained convolutional neural network. A deformation field is estimated by applying the extracted features as input to a second trained convolutional neural network. The deformation field may then be applied to the anatomical image to generate a registered anatomical image.
G06T 3/40 - Changement d'échelle d’images complètes ou de parties d’image, p. ex. agrandissement ou rétrécissement
G06T 7/30 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images
G06V 10/44 - Extraction de caractéristiques locales par analyse des parties du motif, p. ex. par détection d’arêtes, de contours, de boucles, d’angles, de barres ou d’intersectionsAnalyse de connectivité, p. ex. de composantes connectées
71.
MULTI-PLANE-BASED CARDIAC WALL MOTION DETECTION IN MEDICAL ULTRASOUND
To improve the data quality in detecting cardiac wall motion, regions of abnormal wall motion are detected from a view. The scan settings are then changed to focus scanning on each region, providing improved data such as data with more speckle being present. The scan settings may include changing an orientation of the scan plane, reducing out-of-plane motion, and/or increasing speckle content. The improved data is used to more accurately determine strain.
Provided is a cooling fan assembly for a nuclear imaging system where the fan assembly can include a fan, an air inlet opening, an air outlet opening, and a honeycomb structured sheet mounted across the air inlet opening, whereby when the fan is in operation and air is flowing through the air inlet opening, the honeycomb structured sheet facilitates laminar flow of the air at the air inlet opening and attenuates acoustic noise generated by the fan.
F24F 13/08 - Organes de réglage de l'écoulement d'air, p. ex. persiennes, grilles, volets ou plaques directrices
F24F 13/24 - Moyens pour éviter ou supprimer le bruit
F02C 7/045 - Entrées d'air pour ensembles fonctionnels de turbines à gaz ou de propulsion par réaction comportant des dispositifs destinés à supprimer le bruit
F02C 7/055 - Entrées d'air pour ensembles fonctionnels de turbines à gaz ou de propulsion par réaction comportant des dispositifs pour empêcher la pénétration d'objets ou de particules endommageantes comportant des grilles, des écrans ou des dispositifs protecteurs
Systems and methods to partially-gate PET data include acquisition of first data describing a plurality of coincidences detected during a scan of an object, each of the plurality of coincidences associated with a coincidence time and a line of response, determination of lines of response which pass through a region of the object, determination of time periods of motion of the region, modification of the first data to remove coincidences which are associated with the determined lines of response and which are associated with coincidence time during the determined time periods of motion of the region, reconstruction of an image of the object based on the modified first data, and display of the image.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés contenant au moins une liaison peptidique anormale
A61K 38/00 - Préparations médicinales contenant des peptides
C07D 207/16 - Atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
C07D 209/48 - Iso-indolesIso-indoles hydrogénés avec des atomes d'oxygène en positions 1 et 3, p. ex. phtalimide
C07D 233/78 - Radicaux substitués par des atomes d'oxygène
C07D 233/96 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
C07D 239/60 - Trois atomes d’oxygène ou de soufre ou plus
C07D 263/34 - Composés hétérocycliques contenant des cycles oxazole-1, 3 ou oxazole-1, 3 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
C07D 277/56 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 403/06 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée ne contenant que des atomes de carbone aliphatiques
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07K 5/062 - Dipeptides la chaîne latérale du premier amino-acide étant acyclique, p. ex. Gly, Ala
C07K 5/072 - Dipeptides la chaîne latérale du premier amino-acide contenant plus de groupes carboxyle que de groupes amino, ou leurs dérivés, p. ex. Asp, Glu, Asn
75.
A METHOD FOR ORTHO-POSITRONIUM DETECTION AND IMAGING USING A TIME-OF-FLIGHT POSITRON EMISSION TOMOGRAPH
A device for measuring the health of a tissue and a method of use. The device includes a plurality of sensors for detecting an event related to decay of a positron emitted from a pharmaceutical radionuclide in the tissue, and a processor. The processor measures a first count rate indicative of three photon emission related to a first decay mode of the positron, measures a second count rate indicative of two photon emission related to a second decay mode of the positron, applies a scatter correction factor to each of the first count rate and the second count rate to account for scattered and attenuated annihilation photons in the tissue, determines a ratio of the first count rate to the second count rate, determine a decay lifetime for ortho-positronium (o-Ps) based on the ratio, and determines the health of the tissue based on the decay lifetime for o-Ps.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
76.
PET IMAGING USING MULTIPLE ORGAN SPECIFIC SHORT CT SCANS
A method of minimizing a patient's exposure to CT scan radiation during the mu-map generation process in a long axial field of view (FOV) PET scan includes performing a long axial FOV PET scan on a patient; performing one or multiple truncated FOV CT scan of a region in the patient's body in which the organs of interest lies; generating a truncated mu-map covering the truncated CT FOV; and generating a mu-map for the whole long axial FOV of the PET scan by extending the truncated mu-map generated from the truncated FOV CT scan by estimating the missing mu-map data using the PET data.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
For testing or production of a semiconductor-based detector in SPECT, an interposer, such as elastomeric device with conductors, is sandwiched between a carrier and the semiconductor detector. The conductors allow for temporary separate connections of detector electrodes to signal processing circuitry, providing for testing of the detector operating with the signal processing circuitry. The interposer provides separate electrical connections for testing but may also be used in a final, fully integrated detector for use in a SPECT system.
Compounds for targeting and agents for imaging, prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents, as well as methods for imaging PSMA are also disclosed. The imaging agents disclosed are suitable for PET and SPECT imaging.
C07K 5/02 - Peptides ayant jusqu'à quatre amino-acides dans une séquence entièrement déterminéeLeurs dérivés contenant au moins une liaison peptidique anormale
A61K 38/00 - Préparations médicinales contenant des peptides
C07D 207/16 - Atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile
C07D 209/48 - Iso-indolesIso-indoles hydrogénés avec des atomes d'oxygène en positions 1 et 3, p. ex. phtalimide
C07D 233/78 - Radicaux substitués par des atomes d'oxygène
C07D 233/96 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques
C07D 239/60 - Trois atomes d’oxygène ou de soufre ou plus
C07D 263/34 - Composés hétérocycliques contenant des cycles oxazole-1, 3 ou oxazole-1, 3 hydrogéné non condensés avec d'autres cycles comportant deux ou trois liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec des hétéro-atomes ou avec des atomes de carbone comportant trois liaisons à des hétéro-atomes, avec au plus une liaison à un halogène, p. ex. radicaux ester ou nitrile, liés directement aux atomes de carbone du cycle
C07D 277/56 - Atomes de carbone comportant trois liaisons à des hétéro-atomes avec au plus une liaison à un halogène
C07D 401/12 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 403/06 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne carbonée ne contenant que des atomes de carbone aliphatiques
C07D 403/12 - Composés hétérocycliques contenant plusieurs hétérocycles, comportant des atomes d'azote comme uniques hétéro-atomes du cycle, non prévus par le groupe contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07D 405/12 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une chaîne contenant des hétéro-atomes comme chaînons
C07K 5/062 - Dipeptides la chaîne latérale du premier amino-acide étant acyclique, p. ex. Gly, Ala
C07K 5/072 - Dipeptides la chaîne latérale du premier amino-acide contenant plus de groupes carboxyle que de groupes amino, ou leurs dérivés, p. ex. Asp, Glu, Asn
A framework for attenuation correction. An attenuation map may be generated by applying a non-attenuation corrected emission image to one or more trained artificial neural networks. Attenuation correction may be performed on the non-attenuation corrected emission image by using the attenuation map.
A cooling system for cooling a component of an imaging system located in a scan room. The system includes inlet, outlet and return channels. A portion of warm outlet air from a component outlet flows in the return channel to provide warm recirculated air to a mixing zone in the inlet channel. A fan located in the inlet channel draws scan room air into the inlet channel to mix with the warm recirculated air in the mixing zone to form mixed air that flows over the component to cool the component and wherein the mixed air absorbs heat that warms the mixed air to form the warm outlet air. A valve located in the return channel restricts or allows additional warm recirculated air to flow to the mixing zone to mix with the scan room air to maintain a desired control temperature for the cooling system.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
Ottawa Heart Institute Research Corporation (Canada)
Inventeur(s)
Casey, Michael E.
Dekemp, Robert
Abrégé
A system and method include acquisition of emission data from an object while a radioactive tracer is present in the object, determination of first parameters of a first Gaussian distribution representing a positron range distribution of the radioactive tracer, determination of second parameters of a second Gaussian distribution associated with imaging characteristics of the imaging system, generation of a system matrix based on the first parameters and the second parameters, reconstruction of a three-dimensional image based on the emission data and the system matrix, and display of the three-dimensional image.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
Disclosed herein is a furnace and a method of growing a high temperature oxide crystal. The furnace includes a cylindrical furnace wall, an induction coil disposed within the cylindrical furnace wall, a quartz tube disposed within the induction coil, a refractory lining disposed within the quartz tube, and a crucible disposed within the refractory lining, the crucible including a melt therein. A lid placed on the crucible. An asymmetric configuration of at least one of the crucible, the refractory lining, the quartz tube, the induction coil and the lid within the cylindrical furnace wall creates a thermal gradient that causes a cold spot in the melt to migrate from a first location to a second location of the melt. A rod having a seed crystal at an end thereof is lowered into the crucible to draw a boule from the melt via the seed crystal from the first location.
Systems and methods for generating attenuation maps for reconstructing medical images are disclosed. In some examples, measurement data, such as positron emission tomography (PET) data or single-photon emission computed tomography (SPECT) data, is received for a subject. A machine learning process is applied to the measurement data to generate initial synthetic images for multiple values of an imaging parameter. Further, patient data is received and classified to determine an object imaged with the subject. A second medical image is selected that includes the object, and a region-of-interest (ROI) of the initial synthetic images is determined. Further, based on the ROI an anatomical mask is generated for each initial synthetic image. A second image-to-image network process is applied to the patient data, the second medical image, a portion of each initial synthetic image that includes the ROI, and the corresponding anatomical mask to generate a final synthetic image.
2(1-a-b-c-d)2a2b2c 2d(1-x+y)y5(1-z), 5(1-z), wherein Lu is lutetium; A comprises a trivalent ionic substitution selected from La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Sc, Y, Al, Ga, B, In, Bi, Sb, Au, Rh, or a combination thereof; B comprises a non-trivalent ionic substitution selected from Mg, Ca, Sr, Ba, Li, Na, K, Rb, Mn, Cu, Zn, or a combination thereof; C comprises an activating cation substitution selected from Ce3+, Ce4+, Pr3+, or a combination thereof; D comprises a monovalent halogen anion substitution selected from F, Cl, Br, or a combination thereof; E comprises a trivalent ion substitution selected from La, Sc, Y, Al, Ga, In, B, In, Bi, Sb, Au, Rh, or any combination of thereof.
G01T 1/202 - Mesure de l'intensité de radiation avec des détecteurs à scintillation le détecteur étant du cristal
C09K 11/77 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances inorganiques luminescentes contenant des métaux des terres rares
A furnace and a method of growing a high temperature oxide crystal in the furnace. The furnace includes a crucible having a melt therein and a heating element for generating heat in the melt. A thermal element within the furnace produces a thermal gradient within the melt to draw a cold spot of a convection cell of the melt away from a seed location of the crucible. A seed crystal is drawn from the melt at the seed location to form a boule to grow the high temperature oxide crystal.
A furnace and a method of growing a high temperature oxide crystal in the furnace. The furnace includes a crucible having a melt therein and a heating element for generating heat in the melt. A thermal element within the furnace produces a thermal gradient within the melt to draw a cold spot of a convection cell of the melt away from a seed location of the crucible. A seed crystal is drawn from the melt at the seed location to form a boule to grow the high temperature oxide crystal.
C30B 35/00 - Appareillages non prévus ailleurs, spécialement adaptés à la croissance, à la production ou au post-traitement de monocristaux ou de matériaux polycristallins homogènes de structure déterminée
C30B 11/00 - Croissance des monocristaux par simple solidification ou dans un gradient de température, p. ex. méthode de Bridgman-Stockbarger
Disclosed herein is a furnace and a method of growing a high temperature oxide crystal. The furnace includes a cylindrical furnace wall, an induction coil disposed within the cylindrical furnace wall, a quartz tube disposed within the induction coil, a refractory lining disposed within the quartz tube, and a crucible disposed within the refractory lining, the crucible including a melt therein. A lid placed on the crucible. An asymmetric configuration of at least one of the crucible, the refractory lining, the quartz tube, the induction coil and the lid within the cylindrical furnace wall creates a thermal gradient that causes a cold spot in the melt to migrate from a first location to a second location of the melt. A rod having a seed crystal at an end thereof is lowered into the crucible to draw a boule from the melt via the seed crystal from the first location.
C30B 35/00 - Appareillages non prévus ailleurs, spécialement adaptés à la croissance, à la production ou au post-traitement de monocristaux ou de matériaux polycristallins homogènes de structure déterminée
Disclosed herein is a device for manufacturing a single crystal comprising a furnace that includes a furnace wall; a quartz tube disposed concentrically within the furnace wall; an induction coil disposed in an annulus between the quartz tube and the furnace wall; a crucible disposed at a bottom surface of the furnace within the quartz tube; where the crucible includes a wall extending upward from a bottom crucible surface; and a refractory lining being disposed in an annulus between the quartz tube and the crucible; where a portion of the refractory lining has a different composition, property, geometry, or a combination thereof from the remainder of the crucible.
C30B 35/00 - Appareillages non prévus ailleurs, spécialement adaptés à la croissance, à la production ou au post-traitement de monocristaux ou de matériaux polycristallins homogènes de structure déterminée
C30B 15/10 - Creusets ou récipients pour soutenir le bain fondu
C30B 15/14 - Chauffage du bain fondu ou du matériau cristallisé
A crystal growth station includes a crystal pulling assembly having a rotatable pulling shaft and a furnace chamber having an internal area configured to hold a crystal growth chamber which is configured to receive the rotatable pulling shaft. The furnace chamber includes a cover configured to cover the crystal growth station and heating system configured to heat the internal area. At least one of the cover and the heating system includes at least one quick connect fixture.
A crystal growth station includes an adjustable crystal pulling system that implements an adjustment assembly and a motion head coupled to the adjustment assembly. The crystal growth station further includes a moveable furnace chamber configured to be displaced with respect to a docking area of the adjustable crystal pulling system. The adjustment assembly adjusts a position of the motion head with respect to the docking area.
A crystal growth station includes a crystal pulling assembly having a rotatable pulling shaft and a furnace chamber having an internal area configured to hold a crystal growth chamber which is configured to receive the rotatable pulling shaft. The furnace chamber includes a cover configured to cover the crystal growth station and heating system configured to heat the internal area. At least one of the cover and the heating system includes at least one quick connect fixture.
A system and method include generation of a first tomographic image of a subject based on first gamma rays detected by the detector while the detector is disposed at a first position with respect to the subject, generation of a second tomographic image of the subject based on second gamma rays detected by the detector while the detector is disposed at a second position with respect to the subject, identification of one or more structures of the subject depicted in the first tomographic image and the second tomographic image, and generation of a composite tomographic image based on the first tomographic image, the second tomographic image, and the identified one or more structures.
A61B 6/00 - Appareils ou dispositifs pour le diagnostic par radiationsAppareils ou dispositifs pour le diagnostic par radiations combinés avec un équipement de thérapie par radiations
A61B 6/46 - Agencements pour l’interface avec l’opérateur ou avec le patient
93.
CRYSTAL GROWTH STATION INCLUDING ADJUSTABLE CRYSTAL PULLING ASSEMBLY TO FACILITATE RAPID PRODUCTION
A crystal growth station includes an adjustable crystal pulling system that implements an adjustment assembly and a motion head coupled to the adjustment assembly. The crystal growth station further includes a moveable furnace chamber configured to be displaced with respect to a docking area of the adjustable crystal pulling system. The adjustment assembly adjusts a position of the motion head with respect to the docking area.
Disclosed herein is a device for producing a single crystal comprising a furnace, where the furnace comprises a furnace wall, a furnace base plate and a furnace cover; the furnace wall being disposed between the furnace base plate and the furnace cover; a growth chamber comprising an outer tube, a growth chamber bottom plate and a growth chamber top plate; where the furnace cover has an opening through which the growth chamber protrudes and where the growth chamber is operative to contain a crucible that contains a melt for manufacturing the single crystal; a pull rod that contacts the melt to produce a crystal boule; and a conduit disposed between the furnace wall and the outer tube of the growth chamber; where the conduit is operative to transport an inert gas through the furnace to heat the inert gas and to deposit the heated inert gas into the growth chamber.
A system and method includes identification of a first plurality of projection images of an object acquired by an imaging system, each of the first projection images associated with a respective one of a plurality of projection angles, reconstruction of a three-dimensional image of the object based on the first projection images, forward-projection of the three-dimensional image at the plurality of projection angles to generate second projection images, each of the second projection images associated with a respective one of the projection angles, determination of a first CDF image for a first one of the projection angles based on a first one of the first projection images a second one of the second projection images, determination of pixels of the first CDF image corresponding to differences, and combination of the determined pixels with the first one of the first projection images to generate a first combined image.
G06T 1/00 - Traitement de données d'image, d'application générale
G06T 7/32 - Détermination des paramètres de transformation pour l'alignement des images, c.-à-d. recalage des images utilisant des procédés basés sur la corrélation
For robotically operating a catheter, a robotic catheter system controls navigation along a trajectory. The trajectory defines the movement, allowing the robotic catheter system to navigate the catheter with less or no user intervention. The catheter is controlled in a way allowing the operator focus less on the catheter, avoiding or limiting parking or retracting.
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
A61B 8/00 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores
A61B 8/12 - Diagnostic utilisant des ondes ultrasonores, sonores ou infrasonores dans des cavités ou des conduits du corps, p. ex. en utilisant des cathéters
For larger FOV in a gamma camera, multiple solid-state detectors are tiled. The edge pixels of the pixelated detectors are smaller than interior pixels so that the pitch of the pixels or anodes is constant across the tiled detectors. The constant pitch occurs where pairs of edge pixels combined from different detectors contribute the pitch or area of an interior pixel. As a result of this optimized edge pixel pairing and corresponding regular pitch across the tiles, the spectral and other performance is less degraded.
A method and system are disclosed for testing functionality of a software program based on at least one modification to a software code of the software program. In one embodiment, the method includes: receiving software code of software program from one or more sources; identifying functions within the software code of the software program affected by the modification of software code; simulating the identified functions of the software program using digital twin; determining workflows of the software program based on the simulation of digital twin; identifying at least one impacted workflow from determined workflows based on one or more requirements of software program; and executing at least one impacted workflow critical to the functionality of the software program for testing the functionality of software program.
For clutter reduction in ultrasound elasticity imaging, the contribution of clutter to different frequency components (e.g., the transmit fundamental and the propagation generated second harmonic) is different. As a result, a difference in displacements determined at the different frequency bands is used to reduce clutter contribution to displacements used for elasticity imaging.
For assessment of a gamma camera, segmentation of a flood image provides location and size information, providing information for different types of artifacts. A machine-learned model generates an assessment based on input features of the flood image and/or segmentation results. This assessment accounts for size, magnitude, location, and/or type of uniformity.
