A system and method for diagnosing infectious disease using integrated surface acoustic wave sensor technology includes an efficient, low-cost integrated surface acoustic wave (SAW) or bulk acoustic biosensor-based system for point-of-care diagnostics. The SAW or bulk acoustic biosensor, sample receiving portions and interface portions of the system are configured on a disposable cartridge.
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
2.
COMPOSITIONS AND SURFACE ACOUSTIC WAVE BASED METHODS FOR IDENTIFYING INFECTIOUS DISEASE
The disclosure relates to systems and devices for diagnosing infectious disease (e.g., bacterial or viral infections). More particularly, the disclosure relates to acoustic sensors for detecting infectious disease caused by viral infections (e.g., coronavirus, rhinovirus, influenza, etc.).
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
3.
INTEGRATED SURFACE ACOUSTIC WAVE BIOSENSOR SYSTEM FOR POINT-OF-CARE-DIAGNOSTIC USE
A system and method for diagnosing infectious disease using integrated surface acoustic wave sensor technology includes an efficient, low-cost integrated surface acoustic wave (SAW) biosensor based system for point-of-care diagnostics. The SAW biosensor, sample receiving portions and interface portions of the system are configured on a disposable cartridge.
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
4.
INTEGRATED SURFACE ACOUSTIC WAVE BIOSENSOR SYSTEM FOR POINT-OF-CARE-DIAGNOSTIC USE
A system and method for diagnosing infectious disease using integrated surface acoustic wave sensor technology includes an efficient, low-cost integrated surface acoustic wave (SAW) biosensor based system for point-of-care diagnostics. The SAW biosensor, sample receiving portions and interface portions of the system are configured on a disposable cartridge.
The disclosure relates to systems and devices for diagnosing infectious disease (e.g., bacterial or viral infections). More particularly, the disclosure relates to acoustic sensors for detecting infectious disease caused by viral infections (e.g., coronavirus, rhinovirus, influenza, etc.).
C12Q 1/70 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des virus ou des bactériophages
6.
MULTIPLEXING SURFACE ACOUSTIC WAVE SENSORS WITH DELAY LINE CODING
A multiplexing surface acoustic wave (SAW) device for simultaneous excitation of SAW sensors or simultaneous sensing of multiple analytes, targets or bio-agents. The device includes a plurality of SAW sensors arranged in an array. Each sensor has a delay line and each of the delay lines are different in length. The sensors of the multiplexing SAW device are excited simultaneously to generate an array of surface acoustic waves propagating along the delay lines of each SAW sensor. Because the length of each delay line is different for each SAW sensor, the propagation time of the surface acoustic waves varies in based at least in part on the length variation. A compressed pulse train can be generated with a specific time delay according to the length difference of delay lines. Phase or other information of the compressed pulse can be extracted.
Various liquid cells for use in surface acoustic wave-based sensors are disclosed. The sensor can include a substrate, at least one sensor element, and at least one pair of electrical components. The electrical components can be located on opposite ends of the sensor element. The liquid cell can include a top layer that is configured to cover at least a portion of the pair of electrical components. The liquid cell can also include a fluidic channel. The fluidic channel can be configured to receive a liquid media and is arranged not intersect with any of the pair of electrical components. The liquid cell can also include a plurality of peripheral walls that are configured to form a plurality of air pockets. Each of the plurality of air pockets are configured to form virtual non-physical walls to prevent the liquid media from contacting the at least one sensor element.
G01N 29/036 - Analyse de fluides en mesurant la fréquence ou la résonance des ondes acoustiques
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
8.
BIOACTIVE COATING FOR SURFACE ACOUSTIC WAVE SENSOR
An acoustic wave biosensor component is provided. The acoustic wave biosensor comprising a piezoelectric substrate with or without 3D matrix microstructure to increase the surface of the effective sensing area and an anchor substance covalently bound to a surface of the piezoelectric substrate, and the anchor substance can bind to a capture reagent. A process for fabricating the 3D biosensor surface and component coating the surface of a piezoelectric material with bioactive film comprising an anchor substance is also provided.
An acoustic wave biosensor component is provided. A method of amplifying the biosensor signal is also provided, including applying a polymer or metallic material to the analyte after the analyte is attached to the capture agent on the biosensor.
An acoustic wave biosensor component is provided. A method of amplifying the biosensor signal is also provided, including applying a polymer or metallic material to the analyte after the analyte is attached to the capture agent on the biosensor.
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
11.
BIOACTIVE COATING FOR SURFACE ACOUSTIC WAVE SENSOR
An acoustic wave biosensor component is provided. The acoustic wave biosensor comprising a piezoelectric substrate with or without 3D matrix microstructure to increase the surface of the effective sensing area and an anchor substance covalently bound to a surface of the piezoelectric substrate, and the anchor substance can bind to a capture reagent. A process for fabricating the 3D biosensor surface and component coating the surface of a piezoelectric material with bioactive film comprising an anchor substance is also provided.
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
G01N 33/566 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet utilisant un support spécifique ou des protéines réceptrices comme réactifs pour la formation de liaisons par ligand
G01R 19/22 - Dispositions pour procéder aux mesures de courant ou de tension ou pour en indiquer l'existence ou le signe utilisant la conversion d'un courant alternatif en courant continu
12.
MULTIPLEXING SURFACE ACOUSTIC WAVE SENSORS WITH DELAY LINE CODING
A multiplexing surface acoustic wave (SAW) device for simultaneous excitation of SAW sensors or simultaneous sensing of multiple analytes, targets or bio-agents. The device includes a plurality of SAW sensors arranged in an array. Each sensor has a delay line and each of the delay lines are different in length. The sensors of the multiplexing SAW device are excited simultaneously to generate an array of surface acoustic waves propagating along the delay lines of each SAW sensor. Because the length of each delay line is different for each SAW sensor, the propagation time of the surface acoustic waves varies in based at least in part on the length variation. A compressed pulse train can be generated with a specific time delay according to the length difference of delay lines. Phase or other information of the compressed pulse can be extracted.
H01L 41/04 - DISPOSITIFS À SEMI-CONDUCTEURS; DISPOSITIFS ÉLECTRIQUES À L'ÉTAT SOLIDE NON PRÉVUS AILLEURS - Détails - Détails d'éléments piézo-électriques ou électrostrictifs
H01L 41/08 - Eléments piézo-électriques ou électrostrictifs
G01N 29/00 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet
13.
METHODS AND APPARATUS FOR INTERFACING SENSORS WITH FLUID MATERIALS
Various liquid cells for use in surface acoustic wave-based sensors are disclosed. The sensor can include a substrate, at least one sensor element, and at least one pair of electrical components. The electrical components can be located on opposite ends of the sensor element. The liquid cell can include a top layer that is configured to cover at least a portion of the pair of electrical components. The liquid cell can also include a fluidic channel. The fluidic channel can be configured to receive a liquid media and is arranged not intersect with any of the pair of electrical components. The liquid cell can also include a plurality of peripheral walls that are configured to form a plurality of air pockets. Each of the plurality of air pockets are configured to form virtual non-physical walls to prevent the liquid media from contacting the at least one sensor element.
Biosensor components (chips) are described based on direct biocoating processes that result in the tenacious and stable, noncovalent (believed to be chemisorptive) binding of anchor substances such as avidin(s) other proteins having specific binding partners or oligo- or poly-nucleotides onto any piezo-electrically active crystal surface. The resulting platform technology can be developed for a variety of biosensors with specific applications in biological assays. The table mono layers of the anchor substances forms reactive layers, ready to bind a capture reagent such as a biot-inylated antibody for capture and detection of analytes in biologic fluid samples. Although the processes described herein can be performed on any type of piezoelectric material in any number of configurations, some embodiments are directed to a biosensor with the foregoing biocoating onto a particular acoustic plate mode biosensor and where the interdigitated transducers (IDTs) are present on the opposite side of the crystal's biocoated film.
G01N 33/543 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet avec un support insoluble pour l'immobilisation de composés immunochimiques
H01L 41/113 - Eléments piézo-électriques ou électrostrictifs à entrée mécanique et sortie électrique
H01L 41/253 - Traitement de dispositifs ou de leurs parties constitutives afin de modifier une propriété piézo-électrique ou électrostrictive, p.ex. les caractéristiques de polarisation, de vibration ou par réglage du mode
B05D 3/14 - Traitement préalable des surfaces sur lesquelles des liquides ou d'autres matériaux fluides doivent être appliquésTraitement ultérieur des revêtements appliqués, p. ex. traitement intermédiaire d'un revêtement déjà appliqué, pour préparer les applications ultérieures de liquides ou d'autres matériaux fluides par des moyens électriques
G01D 5/14 - Moyens mécaniques pour le transfert de la grandeur de sortie d'un organe sensibleMoyens pour convertir la grandeur de sortie d'un organe sensible en une autre variable, lorsque la forme ou la nature de l'organe sensible n'imposent pas un moyen de conversion déterminéTransducteurs non spécialement adaptés à une variable particulière utilisant des moyens électriques ou magnétiques influençant la valeur d'un courant ou d'une tension
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
G01N 29/34 - Génération des ondes ultrasonores, sonores ou infrasonores
G01N 33/569 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour micro-organismes, p. ex. protozoaires, bactéries, virus
15.
BIOCOATED PIEZOELECTRIC BIOSENSOR PLATFORM FOR POINT-OF-CARE DIAGNOSTIC USE
Biosensor components (chips )are described based on direct biocoating processes that result in the tenacious and stable, noncovalent (believed to be chemisorptive) binding of anchor substances such as avidin(s) other proteins having specific binding partners or oligo- or poly-nucleotides onto any piezoelectrically active crystal surface. The resulting platform technology can be developed for a variety of biosensors with specific applications in biological assays. The table monolayers of the anchor substances forms reactive layers, ready to bind a capture reagent such as a biotinylated antibody for capture and detection of analytes in biologic fluid samples. Although the processes described herein can be performed on any type of piezoelectric material in any number of configurations, some embodiments are directed to a biosensor with the foregoing biocoating onto a particular acoustic plate mode biosensor and where the interdigitated transducers (IDTs) are present on the opposite side of the crystal's biocoated film.
An integrated multiplexed acoustic wave biosensor chip system with enhanced sensitivity has been developed. The biosensor system incorporates one or more microfluidic channels, coated with target-specific binding films enabling rapid and early detection of viral, bacterial or parasitic targets such as Dengue virus and sexually transmitted diseases in specimens from potentially infected patients. The biosensors are used in portable analytical systems that are suitable for real-time point of care (POC) clinical diagnosis in cost sensitive and/or resource limited settings. The highly sensitive biosensors utilize thinned single crystal piezoelectric substrates that propagate layer guided shear horizontal acoustic plate mode (LG-SH-APM) waves in sensing regions bearing immobilized binders that provide simultaneous and direct detection of mass changes due to multiple bound target pathogens or molecules.
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
G01N 30/00 - Recherche ou analyse de matériaux par séparation en constituants utilisant l'adsorption, l'absorption ou des phénomènes similaires ou utilisant l'échange d'ions, p. ex. la chromatographie
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
17.
INTEGRATED SURFACE ACOUSTIC WAVE BIOSENSOR SYSTEM FOR POINT-OF-CARE-DIAGNOSTIC USE
A system and method for diagnosing infectious disease using integrated surface acoustic wave sensor technology includes an efficient, low-cost integrated surface acoustic wave (SAW) biosensor based system for point-of-care diagnostics. The SAW biosensor, sample receiving portions and interface portions of the system are configured on a disposable cartridge.
G01N 29/22 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet Détails
18.
BIOCOATED PIEZOELECTRIC BIOSENSOR PLATFORM FOR POINT-OF-CARE DIAGNOSTIC USE
Biosensor components (chips )are described based on direct biocoating processes that result in the tenacious and stable, noncovalent (believed to be chemisorptive) binding of anchor substances such as avidin(s) other proteins having specific binding partners or oligo- or poly-nucleotides onto any piezoelectrically active crystal surface. The resulting platform technology can be developed for a variety of biosensors with specific applications in biological assays. The table monolayers of the anchor substances forms reactive layers, ready to bind a capture reagent such as a biotinylated antibody for capture and detection of analytes in biologic fluid samples. Although the processes described herein can be performed on any type of piezoelectric material in any number of configurations, some embodiments are directed to a biosensor with the foregoing biocoating onto a particular acoustic plate mode biosensor and where the interdigitated transducers (IDTs) are present on the opposite side of the crystal's biocoated film.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
G01N 29/00 - Recherche ou analyse des matériaux par l'emploi d'ondes ultrasonores, sonores ou infrasonoresVisualisation de l'intérieur d'objets par transmission d'ondes ultrasonores ou sonores à travers l'objet
brevets
