A method for producing a chain-shaped unsaturated carboxylic acid compound or a geometric isomer thereof, having at least two carbon-carbon double bonds, including the steps of: removing, from a chain-shaped unsaturated carboxylic acid compound or a geometric isomer thereof having an amino group and a carbon-carbon double bond at a terminus, that amino group, in the presence of phenylalanine ammonia lyase, and further forming a carbon-carbon double bond.
An object of the present invention is to provide a fluorescent probe that can be used in an enzyme activity detection method. According to the present invention, there is provided a fluorescent probe for detecting a hydrolase, the fluorescent probe containing a compound having at least one water-soluble substituent selected from the group consisting of —CO2H, —PO3H2, and —SO3H and represented by General Formula (II), or a salt thereof. The fluorescent probe of the present invention can be used in an enzyme activity detection method using a microdevice.
An object of the present invention is to provide a fluorescent probe that can be used in an enzyme activity detection method. According to the present invention, there is provided a fluorescent probe for detecting a hydrolase, the fluorescent probe containing a compound having at least one water-soluble substituent selected from the group consisting of —CO2H, —PO3H2, and —SO3H and represented by General Formula (II), or a salt thereof. The fluorescent probe of the present invention can be used in an enzyme activity detection method using a microdevice.
C12Q 1/37 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase faisant intervenir une peptidase ou une protéinase
C09K 11/06 - Substances luminescentes, p. ex. électroluminescentes, chimiluminescentes contenant des substances organiques luminescentes
The present disclosure relates to: a labeled collagen IVα1 protein; a labeled collagen IVα2 protein; nucleic acids encoding said proteins; and animals having said nucleic acids. The present disclosure also relates to a method for observing the labeled collagen IVα1 protein or the labeled collagen IVα2 protein in the animals.
This fluorescence observation device comprises: an excitation light source that irradiates an observation target with excitation light; an imaging unit that captures an observation image using fluorescence emitted by the observation target excited by the excitation light; a light guide optical system that guides the fluorescence to the imaging unit; a fluorescence filter that is disposed on the light incident side of the light guide optical system and transmits light in a wavelength range including the wavelength of the fluorescence; and a light shielding member disposed on the light incident side of the fluorescence filter. The light shielding member shields light incident on the fluorescence filter from a direction intersecting the normal of the fluorescence filter.
This method for determining the risk of a subject developing heart failure is characterized by: including a step for preparing a data list including effect alleles and effect sizes of genetic polymorphism, a step for acquiring genetic information on the subject, a step for calculating a heart failure risk score from genetic information of the subject based on information pertaining to effect alleles and effect sizes of genetic polymorphism in the data list, and a step for determining the risk of heart failure based on the risk score; the data list including genomic analysis results for heart failure in a European and American population, genomic analysis results for heart failure in a population other than Europeans and Americans, genomic analysis results on measurement values related to heart failure subtype, and genomic analysis results on diseases related to heart failure; and the risk score being a combination of the risk scores calculated from these data lists.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
6.
METHOD FOR IMPROVING DIFFERENTIATION EFFICIENCY OF PLURIPOTENT STEM CELLS
Provided is a method for inducing the differentiation of pluripotent stem cells which are obtained by suspension culture with high quality and/or high efficiency. The present invention pertains to a method for producing differentiated cells, the method comprising: a step in which thermal stimulation is applied to pluripotent stem cells after suspension culture of the pluripotent stem cells; a step in which the pluripotent stem cells are subsequently seeded in a culture medium that is different from a culture medium used in the suspension culture; and a step in which agregate mass formation and differentiation induction of the seeded pluripotent stem cells are performed.
This variable-wavelength light source includes: a light output unit that outputs light, the wavelength of the outputted light being variable; a first optical amplification unit that amplifies the light outputted by the light output unit; a filter unit that filters the light amplified by the first optical amplification unit; and a second optical amplification unit that amplifies the light filtered by the filter unit. The first optical amplification unit has a gain on a first-wavelength side that is higher than the gain on a second-wavelength side, the second wavelength being different from the first wavelength. The second optical amplification unit has a gain on the second-wavelength side that is higher than the gain on the first-wavelength side. The filter unit attenuates the natural radiation amplified light.
H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
G02F 1/365 - Optique non linéaire dans une structure de guide d'ondes optique
H01S 3/23 - Agencement de plusieurs lasers non prévu dans les groupes , p. ex. agencement en série de deux milieux actifs séparés
8.
WAVELENGTH CONVERSION OPTICAL SYSTEM AND PULSE LIGHT GENERATION DEVICE
This wavelength conversion optical system includes: a wavelength conversion element in which different light incident positions have different wavelength conversion bands; and a wavelength-specific optical path setting unit for adjusting an optical path for each wavelength band so that light to be converted to the intended wavelength band hits the corresponding incident position in the wavelength conversion element.
A scanning microscope disclosed herein comprises: a pulse light generation device (or a pulse light generation device) that emits excitation light toward a sample, wherein the excitation wavelength of the excitation light is switched for each pulse; and a detector that detects fluorescence from a cell mass S irradiated with the excitation light and outputs a detection signal. The sensor bandwidth of the detector is adjusted so that the detection signal attenuates within a pulse-off period of the excitation light.
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
The purpose of the present invention is to provide a polymer blend exhibiting excellent marine biodegradability even when containing a biodegradable resin having poor biodegradability in a marine environment. The present invention provides a marine biodegradable polymer blend comprising: a polyester-based polymer A having a structural unit (A) derived from a succinic acid, a structural unit (B) derived from a C7 or higher dicarboxylic acid, and a structural unit (C) derived from an aliphatic diol; and a biodegradable polymer B, wherein the polyester-based polymer A and the biodegradable polymer B are in a compatible or incompatible state.
A pulse light generation device 1 comprises: an oscillator 2 for oscillating an ultrashort pulse light L; a stretcher fiber 7 for widening the time width of the ultrashort pulse light L; a fiber amplifier 8 for amplifying the ultrashort pulse light L the time width of which has been widened by the stretcher fiber 7; and a compressor 9 for compressing the time width of the ultrashort pulse light L which has been amplified by the fiber amplifier 8. The stretcher fiber 7 is configured by combining a first fiber 71 for widening the time width of the ultrashort pulse light L with a first characteristic, and a second fiber 72 for widening the time width of the ultrashort pulse light L with a second characteristic which is different from the first characteristic.
H01S 3/10 - Commande de l'intensité, de la fréquence, de la phase, de la polarisation ou de la direction du rayonnement, p. ex. commutation, ouverture de porte, modulation ou démodulation
G02F 1/11 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments acousto-optiques, p. ex. en utilisant la diffraction variable par des ondes sonores ou des vibrations mécaniques analogues
The present invention provides: an agent for reducing the concentration of a protein in blood, the agent containing Pediococcus acidilactici; and a food, a feed, and a medicine each of which is for reducing the concentration of a protein in blood and contains the agent for reducing the concentration of a protein in blood or Pediococcus acidilactici.
A23L 33/135 - Bactéries ou leurs dérivés, p. ex. probiotiques
A23K 10/16 - Ajout de micro-organismes ou de leurs produits d’extraction, p. ex. de protéines provenant d’organismes unicellulaires, à des compositions de produits alimentaires
A61K 35/744 - Bactéries lactiques, p. ex. entérocoques, pédiocoques, lactocoques, streptocoques ou leuconostoques
A61P 3/00 - Médicaments pour le traitement des troubles du métabolisme
A61P 7/00 - Médicaments pour le traitement des troubles du sang ou du fluide extracellulaire
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
13.
POLYNUCLEOTIDE FOR TREATMENT OF NEURODEGENERATIVE DISEASE, VECTOR, CELL, PHARMACEUTICAL COMPOSITION, AND SCREENING METHOD
The purpose of the present invention is to provide a novel method for increasing the number of newly generated neurons in the adult brain, and to provide a polynucleotide, a vector, and a pharmaceutical composition for use in the method. The present invention provides: a polynucleotide characterized by including (A) the nucleic acid sequence of the Plagl2 gene, (B) an miR-shRNA (microRNA adapted short hairpin RNA) nucleic acid sequence for the Dyrk1a gene, and (C) a promoter sequence operatively connected to the nucleic acid sequences; a vector including the polynucleotide; and a pharmaceutical composition including the polynucleotide and the vector.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
C12N 15/113 - Acides nucléiques non codants modulant l'expression des gènes, p. ex. oligonucléotides anti-sens
To improve the luminous efficiency of a UV light-emitting device, the UV light-emitting devices disclosed herein have an AlGaN-based crystal or an InAlGaN-based crystal, and comprise an emission layer, at least one electron blocking layer, a first p-type doped layer, and a composition gradient layer in which the Al composition ratio varies depending on the position over a thickness direction of the layer stack, stacked in this order in the direction of the flow of electrons. The Al composition ratio varies depending on the position over the thickness direction in the composition gradient layer. The UV light-emitting devices are implemented as UV-region light-emitting diodes and laser diodes.
H10H 20/816 - Corps ayant des structures contrôlant le transport des charges, p. ex. couches semi-conductrices fortement dopées ou structures bloquant le courant
H10H 20/825 - Matériaux des régions électroluminescentes comprenant uniquement des matériaux du groupe III-V, p. ex. GaP contenant de l’azote, p. ex. GaN
A quantum device includes a filter having a plurality of notches in a first frequency band lower than a second frequency band, a first qubit that resonates in the first frequency band, and a second qubit that resonates in the second frequency band. The first qubit is input with a signal having a frequency at which the first qubit resonates via the filter to control a state of the first qubit when executing a one-qubit gating, and is input with a signal having a frequency at which the second qubit resonates via the filter to control a state of the second qubit according to a quantum state of the first qubit when executing a two-qubit gating.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
16.
DECODING DEVICE, DECODING METHOD, PROGRAM, AND QUANTUM COMPUTER
A decoding device 1 decodes measurement results of a concatenated quantum code in which a plurality of quantum codes are concatenated, the decoding device including: a level 1 minimum distance candidate calculation unit 11 that, when the number of concatenated quantum codes is L, obtains a minimum distance, which is the minimum value of the Hamming distance between a code word and a measurement result, for each level 1 code block, and selects an encoded bit string corresponding to the minimum distance of each level 1 code block as a minimum distance candidate for each level 1 code block; a level i minimum distance candidate calculation unit 14 that, for i = 2,..., L, obtains the minimum distance for each level i code block by using a level (i-1) minimum distance and minimum distance candidate, for each level i encoded block consisting of a plurality of level (i-1) encoded blocks, and selects an encoded bit string corresponding to the minimum distance of each level i code block as a minimum distance candidate for each level i code block; and an output unit 20 that selects and outputs one of the level L minimum distance candidates.
H03M 13/19 - Correction d'une seule erreur sans utiliser les propriétés particulières des codes cycliques, p. ex. codes de Hamming, codes de Hamming étendus ou généralisés
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p. ex. codes de surface ou distillation d’état magique
1−xx2212−y−δyδ2222. X is at least one element selected from the group consisting of Cr, Sb, In, and V. The relationship 0 ≤ x ≤ 1 is satisfied. The relationships 0 < y ≤ 2 and 0 ≤ δ ≤ 1, or 0 ≤ y ≤ 2 and 0 < δ ≤ 1, are satisfied. The film has a film thickness of at least 1.0 nm and less than 70 μm.
This method for producing mesenchymal cells of the ventral hindgut mesoderm comprises: culturing pluripotent stem cells in an induction medium A containing a TGF-β inhibitor, a Wnt agonist, and a fibroblast growth factor to induce differentiation into epiblast-like cells; culturing the epiblast-like cells in an induction medium B containing a Wnt agonist, a fibroblast growth factor, and retinoic acid to induce differentiation into caudal epiblast-like cells; culturing the caudal epiblast-like cells in an induction medium C containing a Wnt agonist, a bone morphogenetic protein, and a TGF-β family member to induce differentiation into posterior primitive streak cells; and culturing the posterior primitive streak cells in an induction medium D containing a Wnt agonist, a fibroblast growth factor, a bone morphogenetic protein, and a hedgehog signaling agonist to induce differentiation into mesenchymal cells of the ventral hindgut mesoderm.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
19.
TRAVELLING-WAVE PARAMETRIC AMPLIFIER AND QUANTUM INFORMATION PROCESSING SYSTEM
There is provided a travelling-wave parametric amplifier including: a plurality of group cells each including a plurality of unit cells, wherein the plurality of unit cells include: a transmission line that extends along a predetermined direction; and non-linear inductance elements and shunt capacitors arranged along the transmission line, wherein a respective group cell of the plurality of group cells comprises a periodic structure in which the non-linear inductance elements and the shunt capacitors periodically change along the transmission line, and wherein the plurality of group cells comprise a modulation structure in which the non-linear inductance elements and the shunt capacitors modulate along the transmission line.
The present invention provides a catalyst-layer-equipped electrolyte membrane and an application of the same, said catalyst-layer-equipped electrolyte membrane comprising: an anode catalyst layer containing an ionomer and an anode catalyst component that is composed of iridium-containing manganese dioxide, the molar ratio of iridium to manganese in the anode catalyst component being 0.011-0.182, and the logarithm log(amount of ionomer/amount of anode catalyst component) of the ratio of the amount of the ionomer to the amount of the anode catalyst component being −1.40 to −0.46; a proton exchange membrane; and a cathode catalyst layer.
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
C25B 9/77 - Assemblages comprenant plusieurs cellules du type filtre-presse avec diaphragmes
C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
C25B 11/057 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau du substrat ou du support formé d’un seul élément ou composé
C25B 11/079 - Dioxyde de manganèseDioxyde de plomb
An object of the present invention is to provide a cell population suitable for transplant of retinal tissue and a method of production thereof. The present invention provides a cell population for transplant, comprising retinal cells with a modified bipolar cell-regulating gene and a method of production thereof.
In order to provide an IR-QCL element which utilizes the characteristics of a ZnO-based semiconductor material, the present disclosure discloses a quantum cascade laser element 1000 that has a plurality of unit structures 10U in each of which a well layer of ZnO or ZnMgO and a barrier layer of ZnMgO or MgO are alternately and repeatedly stacked. Each unit structure includes a light emitting layer 10E and a continuum layer 10C. The light emitting layer includes: an upstream well layer 10W1 that is composed of a step quantum well having a first layer and a second layer, which have different MgO composition ratios from each other; and a downstream well layer 10W2 that has a smaller MgO composition ratio than any of the first layer and the second layer.
H01S 5/347 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH] dans des composés AIIBVI, p. ex. laser ZnCdSe
23.
NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM, INFORMATION PROCESSING APPARATUS, AND PREDICTION CONTROL METHOD
A non-transitory computer-readable recording medium has stored therein a prediction control program that causes a computer to execute a process. The prediction control program is a prediction control program of a structure prediction model that predicts a three-dimensional structure of an organic compound from sequence information on the organic compound. The process comprises changing an intermediate feature value of the structure prediction model so that a difference between first limiting information and second limiting information different from the first limiting information is lessened, the first limiting information corresponding to a predicted structure output as a prediction result from the structure prediction model.
G16B 15/00 - TIC spécialement adaptées à l’analyse de structures moléculaires bidimensionnelles ou tridimensionnelles, p. ex. relations structurelles ou fonctionnelles ou alignement de structures
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
Provided are: a novel stem cell activator; a topical skin preparation containing the stem cell activator; and a skin cosmetic containing the stem cell activator. The stem cell activator according to the present invention contains, as an active ingredient, at least one compound selected from compounds represented by the following formula (1) (including optical isomers), salts of these compounds, and hydrates thereof. In the formula, R1and R2represent a hydrogen atom or a hydrocarbon group. R3 represents a hydrogen atom or an organic group. n represents an integer of 1 or more. The hydrocarbon group may be substituted.
A61K 31/662 - Acides du phosphore ou leurs esters ayant des liaisons P-C, p. ex. foscarnet, trichlorfon
A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
A61Q 19/00 - Préparations pour les soins de la peau
25.
SHEET-LIKE CELL CULTURE AND METHOD FOR PRODUCING SAME
To provide a method for producing a sheet-like cell culture showing a three-layer structure including a cell layer of superficial cells, a cell layer of intermediate cells, and a cell layer of basal cells, in this order. Provided is a method for producing a sheet-like cell culture that includes culturing a progenitor cell population in a second compartment separated from a first compartment via a porous member to form a sheet-like cell culture in the second compartment. The sheet-like cell culture includes a cell layer of superficial cells derived from the progenitor cell population, a cell layer of intermediate cells derived from the progenitor cell population, and a cell layer of basal cells derived from the progenitor cell population, in this order. The first compartment holds an induction medium containing retinoic acid, bone morphogenetic protein (BMP), and fibroblast growth factor (FGF).
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
A01K 67/0271 - Vertébrés chimériques, p. ex. comprenant des cellules exogènes
A61K 35/12 - Substances provenant de mammifèresCompositions comprenant des tissus ou des cellules non spécifiésCompositions comprenant des cellules souches non embryonnairesCellules génétiquement modifiées
A61L 27/36 - Matériaux pour prothèses ou pour revêtement de prothèses contenant des constituants de constitution indéterminée ou leurs produits réactionnels
A61L 27/40 - Matériaux composites, c.-à-d. en couches ou contenant un matériau dispersé dans une matrice constituée d'un matériau analogue ou différent
A61P 13/10 - Médicaments pour le traitement des troubles du système urinaire de la vessie
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
26.
CONCENTRATION DIFFERENCE POWER GENERATION SYSTEM, POWER GENERATION METHOD, AND METAMATERIAL ABSORBER
Provided is a concentration difference power generation system 100 which utilizes a concentration difference liquid including a first liquid 22 and a second liquid 42 having a concentration lower than that of the first liquid, in order to provide renewable energy power generation which utilizes sunlight and easily adapts power generation amount to demand. The first liquid is in contact with a metamaterial absorber 10. Upon irradiation with sunlight, the metamaterial absorber accelerates evaporation of a solvent from the first liquid in accordance with energy from the sunlight, and increases the concentration of the solute of the first liquid. The concentration difference power generation system additionally comprises, as needed: a first liquid storage unit 30 and an evaporation pool 20 for the first liquid 22; a second liquid storage unit 40 for supplying the second liquid 42; and a concentration difference power generation unit 50.
The present invention facilitates catalyst designing. A catalyst design system according to one embodiment of the present invention is a system for designing a catalyst that promotes a specific chemical reaction, and comprises: an acquisition unit that acquires information for identifying a chemical reaction that is specified by a user and that is to be promoted by the catalyst; an extraction unit that extracts, from a database, information pertaining to a molecular structure included in the chemical reaction identified on the basis of the acquired information, and a state quantity in the process of the chemical reaction; a learning unit that performs machine learning using the information pertaining to the molecular structure and the state quantity that have been extracted from the database, to generate a prediction model; a prediction unit that uses the prediction model to predict a state quantity from the information pertaining to the molecular structure specified by the user; and an identification unit that identifies a dominant factor of the predicted state quantity and displays the dominant factor.
G16C 20/10 - Analyse ou conception des réactions, des synthèses ou des procédés chimiques
G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie
28.
DEVICE FOR ENSURING RELIABILITY OF SERVICE BY DATA SCIENCE, METHOD FOR ENSURING RELIABILITY OF SERVICE BY DATA SCIENCE, AND COMPUTER PROGRAM FOR CAUSING COMPUTER TO EXECUTE SAID METHOD
Provided is a device for ensuring the reliability of a service by data science, the device comprising: an acquisition unit that, for each of a plurality of deviations considered to be likely to occur in a service, acquires grounds information indicating a plurality of grounds for resolving each deviation, the grounds information being agreed upon between a plurality of stakeholders who exchange the service; a generation unit that determines a plurality of first relationships between the plurality of grounds and mutually associates the plurality of grounds on the basis of the plurality of first relationships, thereby generating self-describing information units in which each deviation is accounted for; and a calculation unit that determines a plurality of second relationships between the plurality of self-describing information units generated for each of the plurality of deviations, calculates a feature amount for each of the plurality of self-describing information units, and mutually associates the plurality of feature amounts on the basis of the plurality of second relationships, thereby calculating a reliability feature amount representing the reliability of the service.
MOVING IMAGE PROCESSING DEVICE FOR PROVIDING MOVING IMAGE INDICATING BEAT OF MUSICAL PIECE, MOVING IMAGE PROCESSING METHOD, PROGRAM, AND INFORMATION RECORDING MEDIUM
A moving image processing device (101) provides a moving image indicating the beat of a musical piece being reproduced. A setting unit (102) sets a vicinity position in the vicinity of a predetermined position in a screen. An input unit (103) receives an input of a beat moving image reproduced in synchronization with the musical piece which is reproduced in accordance with a control signal output from a DJ controller. The beat moving image is a moving image in which a beat object associated with each beat of the musical piece moves in the screen, and the beat object associated with the relevant beat reaches the predetermined position in the screen at a beat timing at which the relevant beat of the musical piece is reproduced. Each time a frame of the beat moving image is input, a drawing unit (104) draws a timing object at the set vicinity position in the input frame. An output unit (105) outputs a frame in which the timing object is drawn as a frame of a timing moving image. If a detection unit (106), which may be omitted, detects a scratch operation, the drawing unit (104) also draws a scratch object.
The invention aims to provide a medicament having a superior anti-malignant tumor effect and a method for treating a malignant tumor therewith. In particular, the medicament contains a bacterium and a liposome encapsulating an anti-malignant tumor agent in combination.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/475 - QuinoléinesIsoquinoléines ayant un cycle indole, p. ex. yohimbine, réserpine, strychnine, vinblastine
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
According to an aspect, a fluorescence detection device includes: a light source configured to irradiate a sample with excitation light in a circularly polarized state; a sample holder configured to hold the sample; a cholesteric liquid crystal layer configured to transmit fluorescence emitted by the sample due to the excitation light and reflect the excitation light; and a sensor configured to detect the fluorescence transmitted through the cholesteric liquid crystal layer.
The present invention addresses the problem of providing a tough, fluorescent self-repairing elastomer. The present invention provides a copolymer having a first unit and a second unit that are at least two different types of olefin-derived repeating units, and a third unit that is at least one type of compound-derived repeating unit having at least one type of light-emitting unit in a side chain.
C08F 210/00 - Copolymères d'hydrocarbures aliphatiques non saturés contenant une seule liaison double carbone-carbone
C08F 212/00 - Copolymères de composés contenant un ou plusieurs radicaux aliphatiques non saturés, chaque radical ne contenant qu'une seule liaison double carbone-carbone et l'un au moins étant terminé par un noyau carbocyclique aromatique
C08F 212/14 - Monomères contenant un seul radical aliphatique non saturé contenant un cycle substitué par des hétéro-atomes ou des groupes contenant des hétéro-atomes
ATOM TRAP DEVICE, ATOM COOLING DEVICE, SPECTROSCOPIC DEVICE, OPTICAL LATTICE CLOCK, QUANTUM COMPUTER, COIL, ATOM TRAP METHOD, ATOM COOLING METHOD, AND SPECTROSCOPIC METHOD
This atom trap device 10 for trapping atoms comprises an atom trap unit 16 on which an atomic gas beam is incident. The atom trap unit 16 includes a plurality of optical elements that form a laser light group 18, and a magnetic field generation unit 22. The magnetic field generation unit 22 is provided with at least two spiral coils and, if necessary, a tapered solenoid coil, and optimizes a magnetic field in a guide direction. The spiral coils are configured so that the tip becomes thinner and the winding density becomes sparse as the atoms advance in the direction in which the atoms are guided. The spiral coils are arranged so as to face each other so that an interval therebetween becomes narrower as the atoms advance in the direction in which the atoms are guided. The tapered solenoid coil generates a magnetic field that optimizes the guiding of the atoms and the laser cooling during the guiding by adjusting the component in the direction in which the atoms of the magnetic field generated by the spiral coils are guided. The atom trap unit 16 may also include a baseball coil instead of the spiral coils and the tapered solenoid coil.
The purpose of the present invention is to provide a novel prophylactic and/or therapeutic agent for a neurodegenerative disease, which can increase the number of new neurons in an adult brain. The present invention is a prophylactic and/or therapeutic agent for a neurodegenerative disease, the agent containing, as an active ingredient, an inhibitor of any one of genes shown in table 1 or a protein derived from any one of the genes.
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61P 25/28 - Médicaments pour le traitement des troubles du système nerveux des troubles dégénératifs du système nerveux central, p. ex. agents nootropes, activateurs de la cognition, médicaments pour traiter la maladie d'Alzheimer ou d'autres formes de démence
The present invention relates to: a catalyst precursor for ammonia synthesis, the catalyst precursor including a nitrogen activation catalyst precursor loaded body (A1) in which a precursor of a catalyst component for activating nitrogen is supported by a carrier that is composed of a porous body that has a specific surface area of 1,000 m2/g or more, and a hydrogen activation catalyst precursor loaded body (B1) in which a precursor of a catalyst component for activating hydrogen is supported by a carrier that is different from the above-described carrier; and a catalyst for ammonia synthesis obtained by activating the catalyst precursor.
B01J 35/73 - Catalyseurs caractérisés par leur forme ou leurs propriétés physiques, en général caractérisés par leurs propriétés cristallines, p. ex. semi-cristallines ayant une structure cristalline bidimensionnelle stratifiée, p. ex. hydroxydes doubles lamellaires [HDL]
B01J 37/02 - Imprégnation, revêtement ou précipitation
A gate-definition type quantum-dot structure 1 includes: a quantum-well substrate for confining electrons in a quantum dot; a lead-inducing gate 12 for applying a voltage to a lead 17, which is a supply source of the electrons to the quantum dots, and extending the lead 17 to the vicinity of the quantum dots; a lead-quantum dot barrier-gate 13 for controlling entry and exit of the electrons between the lead 17 and the quantum dots; a plunger gate 14 for adjusting the number of the electrons in the quantum dot; an inter quantum-dot barrier-gate 15 for adjusting strength of tunnel coupling between the adjacent quantum dots; a screening gate 11 for shielding the voltage applied to the lead-quantum dot barrier-gate 13, the plunger gate 14, and the inter quantum-dot barrier-gate 15; and a charge meter for detecting the state of the quantum bit represented by the electrons confined in the quantum dot. The screening gate 11, the lead-inducing gate 12, the lead-quantum dot barrier-gate 13, the plunger gate 14, and the inter quantum-dot barrier-gate 15 are laminated on the quantum-well substrate. The lead 17 is tunnel-coupled with all the quantum dots.
H10D 62/81 - Corps semi-conducteurs, ou régions de ceux-ci, de dispositifs ayant des barrières de potentiel caractérisés par les matériaux de structures présentant des effets de confinement quantique, p. ex. des puits quantiques uniquesCorps semi-conducteurs, ou régions de ceux-ci, de dispositifs ayant des barrières de potentiel caractérisés par les matériaux de structures présentant une variation de potentiel périodique ou quasi-périodique
37.
FABRICATION METHOD FOR ELECTRIC CIRCUIT DEVICE, AND QUBIT DEVICE
Provided is a fabrication method for an electric circuit device, the fabrication method including forming a conductive layer on a substrate, forming a bottom resist layer on the conductive layer, forming a cover layer on the bottom resist layer, forming a top resist layer on the cover layer, forming a contact hole in the substrate by using the top resist layer as a mask, forming a first undercut structure by etching the bottom resist layer below the cover layer, and forming a contact metal layer on a sidewall of the contact hole and above a front surface of the substrate after the first undercut structure is formed.
The present disclosure provides at least one of an iridium-containing manganese oxide that exhibits high oxygen-generating electrode catalytic activity in a water electrolysis method, a catalyst that contains the same, an electrode that contains the catalyst, and a water electrolysis method that uses the electrode. With respect to the iridium-containing manganese oxide according to the present invention, the molar ratio of iridium to manganese is not less than 0.001 but 0.250 or less. In one embodiment, the manganese oxide is manganese dioxide that has a β-type crystal structure. In another embodiment, the ratio of the lattice constant in the a-axis direction to the lattice constant in the c-axis direction is not less than 1.420 but less than 1.521.
C25B 11/093 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un métal noble ou oxyde de métal noble et au moins un oxyde d’un métal non noble
A method for producing methacrylic acid, comprising: decarboxylating mesaconic acid or an isomer thereof in the presence of protocatechuate decarboxylase.
To attain the object of assisting childcare behaviors for promoting stopping of crying of an infant or sleep of an infant, included are: a sensor information acquisition unit (101) that acquires sensor information from a sensor that detects an infant's state; a calculation unit (103) that calculates, on the basis of the sensor information, at least one of heart rate information (IBI) and an infant state score (ISS); an output unit (104) that outputs, in real time, information indicating at least one of the IBI and the ISS; and a notification unit (105) that outputs notification information for notifying a user of a childcare behavior to be performed to promote stopping of crying of the infant or sleep of the infant on the basis of at least one of the length of time elapsed since start of holding and walking has been detected, the IBI, and the ISS.
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/16 - Dispositifs pour la psychotechnieTest des temps de réaction
G16H 10/60 - TIC spécialement adaptées au maniement ou au traitement des données médicales ou de soins de santé relatives aux patients pour des données spécifiques de patients, p. ex. pour des dossiers électroniques de patients
G16H 20/70 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies mentales, p. ex. la thérapie psychologique ou le training autogène
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
41.
TERAHERTZ WAVE DIFFUSER AND METHOD FOR MANUFACTURING THE SAME
This invention disrupts a phase of an incident THz wave. An embodiment of the present disclosure provides a terahertz wave diffuser 100 comprising a dispersion medium 2 and a particulate dispersoid 10. The dispersion medium transmits the incident terahertz wave. The particulate dispersoid is made up of particles 1 each comprising a microstructure and a material responding to the incident terahertz wave, and is supported by being dispersed in the dispersion medium. The present disclosure also provides a method for manufacturing the terahertz wave diffuser.
H01P 11/00 - Appareils ou procédés spécialement adaptés à la fabrication de guides d'ondes, résonateurs, lignes ou autres dispositifs du type guide d'ondes
H05K 9/00 - Blindage d'appareils ou de composants contre les champs électriques ou magnétiques
42.
NATIVE DELIVERY OF BIOMOLECULES INTO PLANT CELLS USING IONIC COMPLEXES WITH CELL-PENETRATING PEPTIDES
The invention relates to a complex comprising a first component: (i) a carrier peptide comprising a cell-penetrating sequence and a polycation sequence: and a second component (ii) a ribonucleic acid (RNA), PNA and/or protein, wherein the carrier peptide is a cyclic peptide comprising at least 2 cysteine residues bridged by a disulphide bond.
Provided is a method for visualizing the denatured state or aggregated state of proteins as a means for detecting denatured or aggregated proteins with high sensitivity, which can be applied even to a protein mixed system, the method comprising a steps of bringing a protein into contact with a nitrobenzoxadiazole derivative, and a steps of detecting the fluorescence of a reaction product of the nitrobenzoxadiazole derivative and the protein.
C07D 271/12 - Composés hétérocycliques contenant des cycles à cinq chaînons comportant deux atomes d'azote et un atome d'oxygène comme uniques hétéro-atomes du cycle condensés avec des carbocycles ou avec des systèmes carbocycliques
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
44.
METHOD FOR PRODUCING MODIFIED NUCLEIC ACID MOLECULE-PEPTIDE COMPLEX, NUCLEIC ACID DISPLAY METHOD OR RIBOSOME DISPLAY METHOD
The method of the present disclosure is a method for producing a modified nucleic acid molecule-peptide complex in which a functional molecule has been introduced into the peptide moiety of a nucleic acid molecule-peptide complex in which a nucleic acid molecule and a peptide encoded by the nucleic acid molecule are linked.
A storage device (10) for storing a target substance (1), which is an irradiation target of a particle beam, comprises: a target container (3) in which an internal space (3a) having an upper opening (3a1) and a lower bottom surface (3a2) is formed; and a sealing member (5a) which is attached to the target container (3) so as to close the opening (3a1) and seal the internal space (3a), and can transmit the particle beam. The bottom surface (3a2) includes a recess (D) recessed downward, and the target substance (1) is disposed in the recess (D).
G21G 1/10 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p. ex. production d'isotopes radioactifs à l'extérieur des réacteurs nucléaires ou des accélérateurs de particules par bombardement avec des particules électriquement chargées
G21G 1/08 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p. ex. production d'isotopes radioactifs à l'extérieur des réacteurs nucléaires ou des accélérateurs de particules par irradiation par des neutrons accompagnée de fission nucléaire
A neutron convergence device (1) comprises a plurality of units (10) connected in the axial direction and a neutron supermirror having a prescribed rotational curved surface shape. Each of the plurality of units (10) includes: a plurality of mirror segments (121) forming a mirror part (12) that constitutes a part of the neutron supermirror having the prescribed curved surface shape; a vacuum chamber (11); and a coupling flange (13) to which the plurality of mirror segments (121) and the vacuum chamber (11) are attached. Each of the plurality of mirror segments (121) is provided with a flange part (122) at one end, and the vacuum chamber (11) is provided with a first flange part (112) at one end and a second flange part (113) at the other end.
G21K 1/06 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant la diffraction, la réfraction ou la réflexion, p. ex. monochromateurs
B23B 5/00 - Machines ou dispositifs à tourner spécialement conçus pour un travail particulierAccessoires correspondants spécialement conçus à cet effet
B24B 29/02 - Machines ou dispositifs pour polir des surfaces de pièces au moyen d'outils en matière souple ou flexible avec ou sans application de produits de polissage solides ou liquides conçus pour pièces particulières
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
The present invention aims to provide an NKT cell ligand-containing preparation that can artificially activate NKT cells in a living body and is useful as an anti-malignant tumor agent and the like.
The present invention aims to provide an NKT cell ligand-containing preparation that can artificially activate NKT cells in a living body and is useful as an anti-malignant tumor agent and the like.
A liposome composition containing a glycolipid selected from the group consisting of a compound represented by the formula (I), a compound represented by the formula (II), and salts thereof:
the formula (I):
The present invention aims to provide an NKT cell ligand-containing preparation that can artificially activate NKT cells in a living body and is useful as an anti-malignant tumor agent and the like.
A liposome composition containing a glycolipid selected from the group consisting of a compound represented by the formula (I), a compound represented by the formula (II), and salts thereof:
the formula (I):
wherein each symbol is as defined in the specification, the formula (II):
The present invention aims to provide an NKT cell ligand-containing preparation that can artificially activate NKT cells in a living body and is useful as an anti-malignant tumor agent and the like.
A liposome composition containing a glycolipid selected from the group consisting of a compound represented by the formula (I), a compound represented by the formula (II), and salts thereof:
the formula (I):
wherein each symbol is as defined in the specification, the formula (II):
wherein each symbol is as defined in the DESCRIPTION.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/7032 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un polyol, c.-à-d. composés ayant plusieurs groupes hydroxyle, libres ou estérifiés, y compris le groupe hydroxyle impliqué dans la liaison glycosidique, p. ex. monoglucosyl-diacylglycérides, acide lactobionique, gangliosides
A61K 39/00 - Préparations médicinales contenant des antigènes ou des anticorps
To provide a method for producing induced pluripotent stem cells (iPS cells) that can initialize somatic cells without using feeder cells or a substrate. For production of iPS cells, the following steps are carried out: I. introducing an initialization gene into a somatic cell; and II. performing initialization and amplification culture of the cell into which the gene has been introduced, in a liquid medium comprising at least one of a protein kinase Cβ (PKCβ) inhibitor and a WNT inhibitor under a suspension culture condition.
Magneto-Optical Trap Device, Physics Package, Physics Package for Optical Lattice Clock, Physics Package for Atomic Clock, Physics Package for Atomic Interferometer, Physics Package for Quantum Information Processing Device, and Physics Package System
In this magneto-optical trap device, five laser beams are irradiated in a trap space in which atoms are trapped. Of the five laser beams, three laser beams (laser beams a1, a2, a3) pass through the inside of the same plane (Z plane) and are irradiated in the trap space. The two laser beams that intersect that plane (laser beams a4, a5) are irradiated in the trap space. The laser beam a1 is used together as a slowing laser beam b for Zeeman slower.
G04F 5/14 - Appareils pour la production d'intervalles de temps prédéterminés, utilisés comme étalons utilisant des horloges atomiques
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
H03L 7/26 - Commande automatique de fréquence ou de phaseSynchronisation utilisant comme référence de fréquence les niveaux d'énergie de molécules, d'atomes ou de particules subatomiques
Provided is a novel compound having excellent antiviral activity. Provided is a compound represented by formula (I) (In the formula, R2and R1or R3, together with a carbon atom on the benzene ring to which these are bonded, form a carbon ring or heterocycle condensed with the benzene ring. R1or R3that does not form said ring, R4, R5, R6and R71-62-61-61-61-61-6 alkoxy-carbonyl group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted acyl group). Also provided is an antiviral agent containing said compound.
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
C01F 11/00 - Composés du calcium, du strontium ou du baryum
C04B 35/01 - Produits céramiques mis en forme, caractérisés par leur compositionCompositions céramiquesTraitement de poudres de composés inorganiques préalablement à la fabrication de produits céramiques à base d'oxydes
C25B 13/07 - DiaphragmesÉléments d'espacement caractérisés par le matériau à base de matériaux inorganiques à base de céramiques
H01B 1/06 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisésEmploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques
H01B 1/08 - Conducteurs ou corps conducteurs caractérisés par les matériaux conducteurs utilisésEmploi de matériaux spécifiés comme conducteurs composés principalement d'autres substances non métalliques oxydes
H01B 13/00 - Appareils ou procédés spécialement adaptés à la fabrication de conducteurs ou câbles
H01M 8/12 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé
H01M 8/124 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par le procédé de fabrication ou par le matériau de l’électrolyte
H01M 8/1246 - Éléments à combustible avec électrolytes solides fonctionnant à haute température, p. ex. avec un électrolyte en ZrO2 stabilisé caractérisés par le procédé de fabrication ou par le matériau de l’électrolyte l'électrolyte étant constitué d’oxydes
A molecular dynamics computation device includes a processor that executes a procedure. The procedure includes: executing machine learning of a first force field for predicting energy for an input structure using, as training data, a structure of a coarse-grained model resulting from coarse-graining an all-atom model sampled by molecular dynamics computation based on an all-atom force field and an energy corresponding to the all-atom model structure; and computing molecular dynamics of a coarse-grained model based on a second force field obtained by combining the first force field that has been subjected to machine learning and an energy based on a coarse-grained model structure.
G06F 30/27 - Optimisation, vérification ou simulation de l’objet conçu utilisant l’apprentissage automatique, p. ex. l’intelligence artificielle, les réseaux neuronaux, les machines à support de vecteur [MSV] ou l’apprentissage d’un modèle
53.
METHOD FOR ASSISTING DIAGNOSIS OF SECONDARY PROGRESSIVE MULTIPLE SCLEROSIS, AND METHOD FOR SCREENING FOR THERAPEUTIC AGENT FOR MULTIPLE SCLEROSIS
NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY (Japon)
RIKEN (Japon)
Inventeur(s)
Yamamura Takashi
Sato Wakiro
Takewaki Daiki
Suda Wataru
Masuoka Hiroaki
Kiguchi Yuya
Kurokawa Rina
Ogata Yusuke
Abrégé
The present invention relates to a method for assisting the diagnosis of secondary progressive multiple sclerosis, the method including: a step in which the relative abundance of Tyzzerella nexilis in a fecal sample collected from a subject is measured; and a step in which, when the relative abundance of Tyzzerella nexilis is larger than that in a fecal sample collected from a normal person, it is determined that the subject has been affected with or is potentially affected with secondary progressive multiple sclerosis. The Tyzzerella nexilis is a bacterium that carries genome DNA having a 97% or higher average nucleotide identity with the nucleotide sequence for the genome DNA represented by SEQ ID NO: 1.
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61P 25/00 - Médicaments pour le traitement des troubles du système nerveux
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
The present invention provides a system for quantifying the effects of a change of a condition pertaining to a subject for a prescribed period, wherein the change, which occurs for the prescribed period, includes at least a change from a first condition to a second condition. The system comprises: a reception means which receives data measured from the subject, the data including first data measured from the subject in the first condition and second data measured from the subject in the second condition; a derivation means which derives, from the received data, at least a first component that represents an accumulation of a load on the subject for the prescribed period and a second component that varies following the change; and an output means which outputs at least one of the derived first component and second component.
G16H 50/30 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le calcul des indices de santéTIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour l’évaluation des risques pour la santé d’une personne
55.
TRANSLUCENT MAGNETIC MATERIAL, OPTICAL ELEMENT AND OPTICAL DEVICE
The present invention provides a translucent magnetic material having excellent optical characteristics. The translucent magnetic material comprises a plurality of magnetic particles which include a plurality of FeCo particles, and a translucent material in which the plurality of magnetic particles are dispersed. The translucent material includes a ceramic material which contains a compound of fluorine and at least one element from among group III, group IV and group V, and a metal material which is disposed in a region between the plurality of FeCo particles and the ceramic material.
G02F 1/09 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments magnéto-optiques, p. ex. produisant un effet Faraday
C23C 14/14 - Matériau métallique, bore ou silicium
G02B 5/00 - Éléments optiques autres que les lentilles
G02B 27/28 - Systèmes ou appareils optiques non prévus dans aucun des groupes , pour polariser
H01F 1/00 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques
H01F 1/20 - Aimants ou corps magnétiques, caractérisés par les matériaux magnétiques appropriésEmploi de matériaux spécifiés pour leurs propriétés magnétiques en matériaux inorganiques caractérisés par leur coercivité en matériaux magnétiques doux métaux ou alliages sous forme de particules, p. ex. de poudre
H01F 10/16 - Métaux ou alliages contenant du cobalt
H01F 41/18 - Appareils ou procédés spécialement adaptés à la fabrication ou à l'assemblage des aimants, des inductances ou des transformateursAppareils ou procédés spécialement adaptés à la fabrication des matériaux caractérisés par leurs propriétés magnétiques pour appliquer des pellicules magnétiques sur des substrats par pulvérisation cathodique
56.
CONTAINER FOR PRODUCING TENSION-APPLIED THREE-DIMENSIONAL ARTIFICIAL SKIN AND PRODUCTION METHOD THEREOF
The culture insert container has a lower culture container having a bottom portion equipped with a porous membrane and a sidewall, and having an upper insertion fixture having a cylindrical sidewall that is inserted into said lower culture container. The cylindrical sidewall has a land arranged so as to protrude from a top end of the sidewall of the lower culture container at a location such as will cause a top surface of said porous membrane and a bottom end portion of the cylindrical sidewall which is inserted within the lower culture container to be maintained in a noncontacting state. A land is arranged at an outer surface of the cylindrical sidewall so as to cause a constant distance to be maintained between an inner surface of the sidewall of the lower culture container and the outer surface of the cylindrical sidewall.
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12M 3/00 - Appareillage pour la culture de tissus, de cellules humaines, animales ou végétales, ou de virus
C12N 5/071 - Cellules ou tissus de vertébrés, p. ex. cellules humaines ou tissus humains
57.
Atom Beam Generation Device, Physics Package, Physics Package for Optical Lattice Clock, Physics Package for Atomic Clock, Physics Package for Atomic Interferometer, Physics Package for Quantum Information Processing Device, and Physics Package System
An atom beam generation device includes an atomic oven including a reservoir in which a sample is contained, a deceleration unit, and coil units. The deceleration unit includes a bore through which an atomic beam and a slowing laser beam pass, and decelerates an atomic beam emitted from the atomic oven by means of slowing laser beam and a magnetic field. The coil units supply Joule heat to the atomic oven, and generate a magnetic field in the deceleration unit.
A learning method includes: causing an observer to perceive information to be compared by the observer from among a plurality of pieces of perceivable information; acquiring evaluation for the information made by the observer; and rating the plurality of pieces of information based on the evaluation made by the observer for the plurality of pieces of information acquired by a plurality of repetitions of the causing the observer to perceive the information and the acquiring the evaluation.
An object of the present invention is to provide a method capable of detecting activity of an enzyme that strictly recognizes a substrate, such as acetylcholinesterase (AChE). There is provided a method for detecting activity of an enzyme in a biological sample using a microdevice, the method including a step of bringing the biological sample into contact with a substrate analog or a natural substrate, and a compound represented by General Formula (I) below or a salt thereof, wherein the substrate analog or the natural substrate generates a compound A having a thiol group (R—SH), a selenol group (R—SeH), or a poly sulfur atom (R—(S)n-H) (R is a hydrogen atom or an alkyl group, and n is 1 to 5) by a reaction with the enzyme, and fluorescence is observed or measured, the fluorescence being emitted or enhanced from a fluorescent product generated by the reaction of the compound represented by General Formula (I) or the salt thereof with the thiol group, the selenol group, or the poly sulfur atom.
G01N 21/77 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique
C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
C12Q 1/34 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase
C12Q 1/46 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir une hydrolase une estérase une cholinestérase
60.
LIGHT EMITTING ELEMENT AND METHOD FOR MANUFACTURING SAME
For the purpose of improving the luminous efficiency of a light emitting element by increasing conduction characteristics, a light emitting element 100 according to an embodiment of the present disclosure includes an AlGaN-based crystal or an InAlGaN-based crystal, and is provided with a light emitting layer 134, at least one electron blocking layer 138, a first Mg-doped layer 140, and a dam layer 150, which are sequentially stacked in this order in the direction of the flow of electrons. The dam layer 150 has a higher Al composition ratio than the first Mg-doped layer. Another embodiment of the present disclosure provides a method for manufacturing a light emitting element that is provided with an Mg-doped layer of any one of a GaN-based crystal, InGaN-based crystal, AlGaN-based crystal, and InAlGaN-based crystal, the method including an activation step for causing an electron catalytic reaction in a first Mg-doped layer so as to activate Mg into an ionized acceptor.
H10H 20/825 - Matériaux des régions électroluminescentes comprenant uniquement des matériaux du groupe III-V, p. ex. GaP contenant de l’azote, p. ex. GaN
H10H 20/816 - Corps ayant des structures contrôlant le transport des charges, p. ex. couches semi-conductrices fortement dopées ou structures bloquant le courant
61.
ALGAN-BASED DEEP ULTRAVIOLET LED AND METHOD FOR MANUFACTURING THE SAME
The present invention enhances light extraction efficiency (LEE) in a 230 nm band UVC-LED. This AlGaN-based deep ultraviolet LED having a light emission wavelength λ has a photonic crystal periodic structure in a thickness direction, wherein the distance between an upper part of a quantum well layer and a bottom part of the photonic crystal periodic structure substantially satisfies a resonance condition λ/n of free end reflection. Here, n is the weighted average refractive index of a layer structure existing between the upper part of the quantum well layer and the bottom part of the photonic crystal periodic structure.
H01L 33/10 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les corps semi-conducteurs ayant une structure réfléchissante, p.ex. réflecteur de Bragg en semi-conducteur
H01L 33/32 - Matériaux de la région électroluminescente contenant uniquement des éléments du groupe III et du groupe V de la classification périodique contenant de l'azote
The present invention addresses the problem of elucidating the function of human Mhr1 and providing a method for improving mitochondrial function. Provided is a method for promoting mitochondrial DNA homoplasmy formation or for improving mitochondrial function, the method including introducing a protein having 80% or higher sequence identity with the amino acid sequence represented by SEQ ID NO: 1 or DNA or mRNA encoding a protein having 80% or higher sequence identity with the amino acid sequence represented by SEQ ID NO: 1 into a cell.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
C12N 5/10 - Cellules modifiées par l'introduction de matériel génétique étranger, p. ex. cellules transformées par des virus
A superconducting coil device includes a superconducting coil and adhesive layer. The superconducting coil includes a superconducting wire wound into a coil shape. An electrical conductivity is imparted to the adhesive layer. The adhesive layer constitutes at least a part of a current bypass for the superconducting coil. The adhesive layer includes a binder. The adhesive layer includes a resistance-decrease suppression structure that imparts the electrical conductivity to the adhesive layer while suppressing a decrease in contact resistance with the superconducting wire.
An objective of the present invention is to provide at least one among: an electrode containing a manganese oxide which suppresses the elution of manganese during water electrolysis without reducing hydrogen productivity; and a method for manufacturing the electrode. The electrode includes a conductive substrate, and an oxygen generating electrode catalyst containing iridium-manganese oxide. The content of iridium per geometric area of the conductive substrate is less than 10 μg/cm2.
C25B 11/093 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un métal noble ou oxyde de métal noble et au moins un oxyde d’un métal non noble
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
C25B 9/23 - Cellules comprenant des électrodes fixes de dimensions stablesAssemblages de leurs éléments de structure avec des diaphragmes comprenant des membranes échangeuses d'ions dans ou sur lesquelles est incrusté du matériau pour électrode
Provided is a device for estimating the atomic structure of a biomolecule, the device comprising: a generation unit that generates an image generated on the basis of a target biomolecule; an acquisition unit that acquires a plurality of first candidate structure images on the basis of two-dimensional projection images from a plurality of atomic structures prepared; a global search unit that, on the basis of the similarity between the generated image and the candidate structure images, selects, as a basic candidate structure, a structure having a high degree of structural similarity and/or molecular orientation similarity to the target biomolecule from among the plurality of atomic structure candidate structures; and a local search unit that acquires a plurality of second candidate structure images on the basis of two-dimensional projection images of a plurality of modified atomic structures obtained by modifying the basic candidate structure, and selects, on the basis of the similarity between the second candidate structure images and the generated image, a structure having a high degree of structural similarity and/or molecular orientation similarity to the target biomolecule from among the modified atomic structures.
G16C 10/00 - Chimie théorique computationnelle, c.-à-d. TIC spécialement adaptées aux aspects théoriques de la chimie quantique, de la mécanique moléculaire, de la dynamique moléculaire ou similaires
G16C 20/40 - Recherche de structures chimiques ou de données physicochimiques
This inspecting device is a device for inspecting an inner circumferential surface of an object under inspection that has a cylindrical shape. The device comprises: an inspecting unit for emitting terahertz waves toward the inner circumferential surface and detecting reflected waves of the terahertz waves; and a distance measuring unit for measuring the distance between the inspecting unit and the inner circumferential surface. The inspection target and the distance measuring unit are caused to rotate in the circumferential direction of the object under inspection. Further, the relative axial position of the inspecting unit with respect to the object under inspection is adjusted. Further, the position of the inspecting unit in a plane intersecting the axial direction of the object under inspection can be adjusted. Control of the position adjustment mechanism is performed on the basis of the measurement result from the distance measuring unit such that the center of rotation of a rotation unit is positioned on the central axis of the object under inspection.
G01B 15/04 - Dispositions pour la mesure caractérisées par l'utilisation d'ondes électromagnétiques ou de radiations de particules, p. ex. par l'utilisation de micro-ondes, de rayons X, de rayons gamma ou d'électrons pour mesurer des contours ou des courbes
67.
FILTER CIRCUIT, QUANTUM DEVICE, QUANTUM COMPUTER, FILTER CIRCUIT MANUFACTURING METHOD, FILTER CIRCUIT ASSEMBLY METHOD, READOUT FREQUENCY FILTERING METHOD, AND QUANTUM BIT DISPERSIVE READOUT METHOD
A filter circuit 1 comprises: a readout resonator 11 that is coupled to data quantum bits; and a filter resonator 12 that is configured and is coupled to an observation line. The readout resonator 11 and the filter resonator 12 are electrically and magnetically coupled by using capacitive coupling and inductive coupling in parallel.
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
G06N 10/70 - Correction, détection ou prévention d’erreur quantique, p. ex. codes de surface ou distillation d’état magique
Provided is an electrode exhibiting high oxygen generating electrode catalytic activity as compared with conventional electrodes using manganese-based oxide as an oxygen generating electrode catalyst.
C25B 11/093 - Électrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé d’au moins un élément catalytique et d’au moins un composé catalytiqueÉlectrodes comportant des électro-catalyseurs sur un substrat ou un support caractérisées par le matériau électro-catalytique formé de plusieurs éléments catalytiques ou composés catalytiques au moins un métal noble ou oxyde de métal noble et au moins un oxyde d’un métal non noble
C25B 1/04 - Hydrogène ou oxygène par électrolyse de l'eau
C25B 9/00 - Cellules ou assemblages de cellulesÉléments de structure des cellulesAssemblages d'éléments de structure, p. ex. assemblages d'électrode-diaphragmeCaractéristiques des cellules relatives aux procédés
C25B 11/042 - Électrodes à base d’un seul matériau
C25B 11/052 - Électrodes comportant un substrat et un ou plusieurs revêtements électro-catalytiques
C25B 11/079 - Dioxyde de manganèseDioxyde de plomb
(1) The purpose of the present invention is to provide an antitumor agent in which an effect of an immune checkpoint inhibitor is enhanced. (2) The purpose of the present invention is also to provide a drug that could exhibit an effect even under conditions in which no antigen is present. (1) Provided is an antitumor agent obtained by combining an immune checkpoint inhibitor with an NKT cell ligand-containing liposome composition. (2) Also provided is a liposome composition containing an NKT cell ligand and an antigen.
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 31/7032 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un polyol, c.-à-d. composés ayant plusieurs groupes hydroxyle, libres ou estérifiés, y compris le groupe hydroxyle impliqué dans la liaison glycosidique, p. ex. monoglucosyl-diacylglycérides, acide lactobionique, gangliosides
In order to achieve a charged particle beam sensor capable of measuring beam position with high linearity, provided is a charged particle beam sensor comprising a plurality of electrodes 1-8 that cover a right cylinder side surface. The plurality of electrodes are insulated from each other by a plurality of separation curves which each draw, with respect to a direction along the axis of the right cylinder side surface, a curve from the minimum value to the maximum value of a sine wave relating to a rotation angle in any rotation direction around the axis of the right cylinder side surface. The charged particle beam is disposed so as to pass through the inside of the right cylinder side surface. In a measurement data processing method, a signal wave second-order integral value is calculated.
G01T 1/29 - Mesure effectuée sur des faisceaux de radiations, p. ex. sur la position ou la section du faisceauMesure de la distribution spatiale de radiations
71.
METHOD FOR ACQUIRING VALUE OF AUTONOMIC NERVOUS SYSTEM INDEX FOR EVALUATING MENTAL STATE OF SUBJECT, AND METHOD, SYSTEM, AND PROGRAM FOR EVALUATING MENTAL STATE OF SUBJECT
The present invention provides a method for acquiring the value of an autonomic nervous system index for evaluating the mental state of a subject. The method comprises acquiring the value of the autonomic nervous system index of the subject at a first time point and a second time point. The autonomic nervous system index or a calculated value thereof serves as an index of the mental state of the subject. The method is characterized in that the sleep state of the subject at the first time differs from at the second time point. The present invention also provides a method, for example, for evaluating the mental state of a subject on the basis of an acquired value of an autonomic nervous system index or a calculated value thereof.
The purpose of the present invention is to provide a novel HVEM-binding protein. The present invention provides a human HVEM-binding protein comprising at least one immunoglobulin single variable region, wherein: the immunoglobulin single variable region includes complementarity determining regions 1-3 which have the amino acid sequence of SEQ ID NO: 1, the amino acid sequence of SEQ ID NO: 2, and the amino acid sequence of SEQ ID NO: 3, respectively; and the immunoglobulin single variable region is a humanized VHH. The protein according to the present invention may further comprise a human immunoglobulin Fc region or a human serum albumin-binding protein, and the immunoglobulin Fc region may be an Fc region of human IgG4.
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
A61K 39/395 - AnticorpsImmunoglobulinesImmunsérum, p. ex. sérum antilymphocitaire
A61K 45/00 - Préparations médicinales contenant des ingrédients actifs non prévus dans les groupes
A61K 47/68 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un anticorps, une immunoglobuline ou son fragment, p. ex. un fragment Fc
A film deposition method including installing a substrate on a turntable of a spin coating device such that a first main surface faces the turntable, and adding a first liquid having viscosity dropwise onto a second main surface of the substrate; holding the substrate in the same state until the first liquid added dropwise reaches the first main surface side from the second main surface side through a through-hole; otating the substrate together with the turntable; and heating the first liquid together with the substrate.
A method of producing radionuclides includes installation, irradiation, transport, and trapping steps. In the installation step, a target material containing a target nuclide is placed inside a target chamber. In the irradiation step, at least a portion of the target material is irradiated with a quantum beam. In the transport stage, a carrier gas is supplied to the inside of the target chamber and an ambient gas around the target material is sent to the outside of the target chamber through an exhaust pipe. In the trapping step, a trap device connected to the exhaust pipe is configured to trap the radionuclides produced from the target nuclide from the ambient gas. In some cases, a target holding device for quantum beam irradiation comprising a target material container and a rotational drive mechanism is also provided, as well as a quantum beam irradiation system. An example target material container is rotatable.
G21G 1/04 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p. ex. production d'isotopes radioactifs à l'extérieur des réacteurs nucléaires ou des accélérateurs de particules
G21G 1/00 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p. ex. production d'isotopes radioactifs
G21K 5/08 - Supports pour cibles ou pour objets à irradier
The present invention provides a plant root system morphology control means which is effective and easy to use. The present invention provides a plant root system morphology control agent comprising 2-aminopimelic acid or a salt or ester thereof.
A01N 37/44 - Biocides, produits repoussant ou attirant les animaux nuisibles, ou régulateurs de croissance des végétaux, contenant des composés organiques comportant un atome de carbone possédant trois liaisons à des hétéro-atomes, avec au plus deux liaisons à un halogène, p. ex. acides carboxyliques contenant au moins un groupe carboxylique ou un thio-analogue, ou un de leurs dérivés, et un atome d'azote lié au même squelette carboné par une liaison simple ou double, cet atome d'azote ne faisant pas partie d'un dérivé ou d'un thio-analogue d'un groupe carboxylique, p. ex. acides aminocarboxyliques
A01G 7/06 - Traitement des arbres ou des plantes en cours de croissance, p. ex. pour prévenir la décomposition du bois, pour teinter les fleurs ou le bois, pour prolonger la vie des plantes
A01H 3/04 - Procédés de modification des phénotypes par traitement au moyen de produits chimiques
A01P 21/00 - Régulateurs de croissance des végétaux
76.
DATA INTEGRATION APPARATUS, DATA INTEGRATION METHOD AND PROGRAM, AND DIGITAL CITY CREATION SYSTEM
A data integration apparatus according to one embodiment includes a controller including a platform for automatically performing a type conversion of an object, an acquisition unit, an interpreter, and an integrator. The acquisition unit acquires each data as a graph in which an object of the platform is a constituent element, or as a collection of information in a language format in which an object is associated with a word. The interpreter performs an interpretation process for converting the constituent element of the graph into a type on a hyponymy-side. The integrator performs an integration process for holding information generated by the interpretation process and information acquired by the acquisition unit, and reflecting the information on the graph. The data integration apparatus operates when the controller repeatedly and automatically performs the interpretation process and the integration process.
G06F 30/12 - CAO géométrique caractérisée par des moyens d’entrée spécialement adaptés à la CAO, p. ex. interfaces utilisateur graphiques [UIG] spécialement adaptées à la CAO
G06F 30/13 - Conception architecturale, p. ex. conception architecturale assistée par ordinateur [CAAO] relative à la conception de bâtiments, de ponts, de paysages, d’usines ou de routes
Provided is an LED having a quantum well structure and comprising: a quantum well layer having a composition AlaGa1-aN (aluminum gallium nitride) (0 < a < 1); and a high-level layer that has a composition AlbGa1-bN (a < b ≤ 1), is adjacent to the quantum well layer, and has an energy level higher than that of the quantum well layer. ΔX, which is the difference between a and b, and the width D [nm] of the quantum well layer satisfy [relational expression 1] D = k/ΔX (where, in the relational expression 1, D > 3, 0 < ΔX < 0.15, and 0.45 ≤ k ≤ 1.25 (unit of the coefficient k is [nm])).
H01L 33/06 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les corps semi-conducteurs ayant une structure à effet quantique ou un superréseau, p.ex. jonction tunnel au sein de la région électroluminescente, p.ex. structure de confinement quantique ou barrière tunnel
H01L 33/14 - DISPOSITIFS À SEMI-CONDUCTEURS NON COUVERTS PAR LA CLASSE - Détails caractérisés par les corps semi-conducteurs ayant une structure contrôlant le transport des charges, p.ex. couche semi-conductrice fortement dopée ou structure bloquant le courant
H01L 33/32 - Matériaux de la région électroluminescente contenant uniquement des éléments du groupe III et du groupe V de la classification périodique contenant de l'azote
H01S 5/343 - Structure ou forme de la région activeMatériaux pour la région active comprenant des structures à puits quantiques ou à superréseaux, p. ex. lasers à puits quantique unique [SQW], lasers à plusieurs puits quantiques [MQW] ou lasers à hétérostructure de confinement séparée ayant un indice progressif [GRINSCH] dans des composés AIIIBV, p. ex. laser AlGaAs
The present invention pertains to: a guide RNA having, on the 5' side of a spacer sequence, a repeat sequence that is cleaved through processing for forming a cascade complex, and not having a repeat sequence or having a sequence that is not cleaved through processing for forming a cascade complex, on the 3' side of the spacer sequence; and a type-I CRISPR-Cas system using the guide RNA.
A sample preparation system (100) includes a position identification section (34) that associates a plurality of cells constituting a cell group with the respective plurality of cells constituting the cell group in which at least a part of junctions between adjacent ones of the plurality of cells is disconnected, in a dispersion process of (i) disconnecting at least the part of the junctions between the adjacent ones of the plurality of cells in the cell group in which the plurality of cells are joined to each other and (ii) dispersing the cell group. This allows the realization of a technique of collecting a cell and specifying the position of the collected cell in an original cell group.
An observation device includes a neutron emission device, a detection device, and a data processing device. The neutron emission device emits neutrons to an inspection object. The detection device detects exit neutrons from the inspection object at one set of detection positions in a peripheral direction around the inspection object, outside the inspection object, and measures the number of the detected exit neutrons for each of the detection positions. The data processing device generates reconstructed cross-sectional data by performing reconstruction processing based on the number of the detected exit neutrons at each of the one set of detection positions. The reconstructed cross-sectional data represent a two-dimensional distribution of a neutron reaction rate in an imaginary cross-section of the inspection object.
G01N 23/05 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et formant des images des matériaux en utilisant des neutrons
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (Japon)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventeur(s)
Yamamoto Michihisa
Takada Shintaro
Bauerle Christopher
Abrégé
Provided is a quantum computer, including: an input unit for inputting an electron wave packet; a propagation unit that propagates the electron wave packet in a predetermined direction and has a loop-like loop path; and a qubit generation unit that generates a time-bin qubit by using the electron wave packet.
G06N 10/20 - Modèles d’informatique quantique, p. ex. circuits quantiques ou ordinateurs quantiques universels
G06N 10/40 - Réalisations ou architectures physiques de processeurs ou de composants quantiques pour la manipulation de qubits, p. ex. couplage ou commande de qubit
Provided is a method for efficiently preparing a library. The method for preparing a library includes the steps of (a) synthesizing single-stranded cDNA from 10 pg or more of template RNA; (b) synthesizing double-stranded cDNA from the single-stranded cDNA; and (c) preparing a library using the double-stranded cDNA that is unpurified.
NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (Japon)
RIKEN (Japon)
Inventeur(s)
Furukawa Taiki
Oyama Shintaro
Yokota Hideo
Abrégé
This information processing device is provided with a state information acquisition unit and an analysis processing unit. The state information acquisition unit continuously acquires objective state information of a patient suffering from a disease, and subjective state information based on the patient's subjectivity. On the basis of the objective state information and the subjective state information, and using a predetermined information processing technique, the analysis processing unit continuously executes predetermined analysis processing including setting of a policy recommended to be executed by the patient in order to improve the symptom of the disease, and outputs the result of the analysis processing in a manner that can be perceived by the patient.
G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
G16H 50/20 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour le diagnostic assisté par ordinateur, p. ex. basé sur des systèmes experts médicaux
84.
ESTIMATION DEVICE, ESTIMATION SYSTEM, ESTIMATION METHOD, AND PROGRAM
Provided is an estimation device comprising a control unit that executes an estimation process for estimating dynamic information, which is information relating to the behavior of platelets, on the basis of video data from a video showing the flow of platelets in the blood. In the estimation process, the control unit executes a correlation acquisition process for, on the basis of the video data, acquiring information indicating a correlation among frames, from among a plurality of frames included in the video, satisfying the condition that a difference in time indicated by a time code is smaller than a preset time difference, and estimates the dynamic information on the basis of the result of the correlation acquisition process.
G06V 10/62 - Extraction de caractéristiques d’images ou de vidéos relative à une dimension temporelle, p. ex. extraction de caractéristiques axées sur le tempsSuivi de modèle
85.
COMPOSITION FOR DECOMPOSITION OF TRYPSIN OR TMPRSS2
A composition for decomposition of trypsin or TMPRSS2 containing, as an active ingredient, bacteria that have 00502 protein, or a protein having 30% or higher sequence identity with an amino acid sequence of the 00502 protein and having a trypsin-binding ability; or bacteria that have 00509 protein, or a protein having 30% or higher sequence identity with an amino acid sequence of the 00509 protein and having a trypsin-binding ability.
The preventive or therapeutic agent for benign adult familial myoclonus epilepsy (BAFME) of the present invention contains an antisense oligonucleotide containing at least one of the base sequences of SEQ ID NOS: 1 to 4. Among the antisense oligonucleotides, oligonucleotide consisting of at least one of the base sequences of SEQ ID NOS: 1 to 4 may contain at least one RNase H inactive type nucleotide analog. The RNase H inactive type nucleotide analog may be β-D-oxy-L-LNA, β-D-ENA, R type cEt, 2′-OMe-nucleotide analog, and/or MOE-nucleotide analog.
Provided are: a composition for ammonia storage and an ammonia bonding composition, with which ammonia can be stored relatively easily under mild conditions and can be stored with high safety; and an ammonia storage device and an ammonia storage method, which use same. The composition for ammonia storage contains a compound for ammonia storage which is represented by any of specific formulae (I-a) to (I-c). In addition, the ammonia bonding composition contains said composition for ammonia storage and is obtained by bonding the compound to an ammonia molecule and a water molecule. In addition, the ammonia storage device, the ammonia storage method and an ammonia molecule removal method use the foregoing.
The present invention relates to a method for conducting phylogenetic analysis of cells. The method of the present invention includes steps of: (1) comparing, for a plurality of single cells derived from the same individual, the RNA sequence data of the transcriptome of each single cell with the corresponding genome sequence data, and then screening for a site where the RNA sequence differs from the genome sequence; (2) screening the sites identified by screening in step (1) for a site where three or more single nucleotide polymorphisms are detected, as a site of somatic mutation; and (3) generating a cell lineage tree based on the nucleotide sequence information of the site of somatic mutation obtained in step (2).
Provided is a technique for examining an autoimmune disease. This method for examining an autoimmune disease involves (1) a step for examining the presence or absence of endogenous human herpesvirus 6B in genomic DNA of a biological sample sampled from a subject.
Provided is a novel drug for tumor therapy which targets an S1P signaling pathway. A tumor therapeutic agent according to one embodiment of the present invention which comprises a complex that includes an acrolein reaction site having a chemical structure represented by formula (1), and a detachment site, wherein the detachment site is bonded to the acrolein reaction site via a linker that can be cleaved by a reaction between the acrolein reaction site and acrolein, and the detachment site includes a chemical structure of a compound which exhibits an activity for inhibiting sphingosine-1-phosphate signal transduction in a cell.
The present invention aims to provide a method for suppressing differentiation of ganglion cell, amacrine cell, horizontal cell and/or bipolar cell in a neural retina tissue containing photoreceptor precursor and/or photoreceptor, and the like. A method for suppressing differentiation of a ganglion cell, an amacrine cell, a horizontal cell and/or a bipolar cell in a neural retinal tissue containing a photoreceptor precursor and/or a photoreceptor, including a step of culturing a retinal tissue comprising a neural retinal progenitor cell and in any stage between a differentiation stage immediately after emergence of a ganglion cell and a differentiation stage where emergence rate of a cone photoreceptor precursor reaches maximum in a medium containing a thyroid gland hormone signal transduction pathway agonist.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
92.
FOOD QUALITY MONITORING APPARATUS AND FOOD QUALITY MONITORING METHOD
A quality monitoring apparatus (10) is provided with a quality measurement device (30) that irradiates a food (1) with an electromagnetic wave, and measures an index value indicating the quality state of the food (1) on the basis of the response of the food (1) to the irradiation. The quality measurement device (30) is provided with a Raman scattered light measurement device (30A) that irradiates a food with laser light as an electromagnetic wave, and measures, as an index value, a value related to the intensity of Raman scattered light generated from the food 1 with respect to the laser light. Alternatively, the quality measurement device (30) is provided with a terahertz wave measurement device (30B) that irradiates the food (1) with a terahertz wave as an electromagnetic wave, and measures, as an index value, a value related to the absorption rate of the terahertz wave in the food (1).
A23L 5/30 - Traitement physique, p. ex. par des moyens électriques ou magnétiques, par énergie ondulatoire ou par irradiation
F24C 7/04 - Poêles ou fourneaux chauffés à l’électricité dans lesquels la chaleur est rayonnée directement par l'élément chauffant
G01N 21/3586 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant la lumière de l'infrarouge lointainCouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge en utilisant un rayonnement térahertz par spectroscopie térahertz dans le domaine temporel [THz-TDS]
93.
METHOD FOR MATURING CARDIOMYOCYTES, AND METHOD FOR PRODUCING MATURED CARDIOMYOCYTES
A method for producing matured cardiomyocytes, the method comprising: a preparation step for preparing a sample containing immature cardiomyocytes; and a pressure loading step for continuously or intermittently applying hydrostatic pressure to the sample.
In one embodiment of the present disclosure, in order to increase production efficiency of astatine (At)-211, provided is a method for producing At by α-particle beam irradiation, and the method includes: an installation step S32 for receiving and arranging, in a housing part of a target material container (3), a target material (4) containing bismuth (Bi)-209; a rotation drive irradiation step S40 for irradiating at least a portion of the target material (4) with an α-particle beam (2) while rotating the target material container (3) around a rotation axis; a transportation step S46, after said step S40, for supplying a carrier gas and sending, through an exhaust pipe, an atmospheric gas around the target material; and a collection step S46 for collecting, from the atmospheric gas, astatine-211 generated from Bi by the irradiating with the α-particle beam. In a preferred embodiment of the present disclosure, the rotation drive irradiation step is performed with Bi of the target material in a solid state. Further, in a preferred embodiment of the present disclosure, the target material container is heated to a temperature higher than the melting point of Bi and lower than the boiling point of Bi in either or both of the transportation step or the collection step.
G21K 5/08 - Supports pour cibles ou pour objets à irradier
G21G 1/10 - Dispositions pour la conversion des éléments chimiques par rayonnement électromagnétique, radiations corpusculaires ou bombardement par des particules, p. ex. production d'isotopes radioactifs à l'extérieur des réacteurs nucléaires ou des accélérateurs de particules par bombardement avec des particules électriquement chargées
G21K 1/00 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer
95.
CELL LABELING MOLECULE AND METHOD FOR ANALYZING CELL
A cell labeling molecule comprising a particle 101 having an identifiable property, an identification sequence 102 that is identifiable and corresponds to the property of the particle 101, a cleavable linker 103 that binds the particle 101 and the identification sequence 102, and a binding molecule 104 for binding to a cell, the binding molecule being bound to the identification sequence 102.
G01N 33/58 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des substances marquées
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
Provided is an ATAC-seq method including: step (a) for contacting a transposome with a chromatin and tagmenting an open chromatin region to obtain a population of tagmented DNA fragments, wherein the transposome is a complex in which a DNA fragment having a transposase binding sequence and a desired nucleotide sequence is bound to the transposase bound, and each of the tagmented DNA fragments has the desired nucleotide sequence at the end; step (b) for amplifying and sequencing the population of the tagmented DNA fragments to obtain a population of reads; and step (c) for analyzing the population of the reads. In this ATAC-seq method, the desired nucleotide sequence includes a nucleotide sequence for amplification and a recognition sequence in this order in the 5'- to 3'-direction, and the amplification of the population of the tagmented DNA fragments is performed using a primer specific to a target region on the genomic DNA and a primer specific to the nucleotide sequence for amplification.
The present invention relates to a method for labeling a cell with a barcode. The method for labeling a cell with a barcode of the invention includes (1) for a cell group containing a plurality of single cells, directly or indirectly bringing a cell surface protein of the cell into contact with a modified barcode; or (2) directly or indirectly bringing a cell surface protein of a single cell into contact with a modified barcode.
C12Q 1/6876 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes
C12Q 1/6804 - Analyse d’acides nucléiques utilisant des immunogènes
C12Q 1/6874 - Méthodes de séquençage faisant intervenir des réseaux d’acides nucléiques, p. ex. séquençage par hybridation [SBH]
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
98.
LIQUID JET GENERATION DEVICE AND X-RAY SPECTROSCOPIC DEVICE
A liquid jet generation device 100 according to the present embodiment generates and recovers a jet of a liquid in a vacuum, and comprises: a vacuum chamber 70; a discharge device 10 that discharges a liquid into the vacuum chamber; a catcher assembly 20 that has a skimmer 21 for recovering the liquid discharged from the discharge device; and a first positioning device 30 that positions the catcher assembly with respect to the liquid. It is thereby possible to form a liquid jet in a vacuum and recover the liquid from the vacuum.
G01N 1/28 - Préparation d'échantillons pour l'analyse
B05B 1/14 - Buses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage avec des orifices de sortie multiplesBuses, têtes de pulvérisation ou autres dispositifs de sortie, avec ou sans dispositifs auxiliaires tels que valves, moyens de chauffage avec des filtres placés dans ou à l'extérieur de l'orifice de sortie
B05C 11/00 - Parties constitutives, détails ou accessoires non prévus dans les groupes
B05C 11/10 - Stockage, débit ou réglage du liquide ou d'un autre matériau fluideRécupération de l'excès de liquide ou d'un autre matériau fluide
G01N 23/083 - Recherche ou analyse des matériaux par l'utilisation de rayonnement [ondes ou particules], p. ex. rayons X ou neutrons, non couvertes par les groupes , ou en transmettant la radiation à travers le matériau et mesurant l'absorption le rayonnement consistant en rayons X
G21K 1/06 - Dispositions pour manipuler des particules ou des rayonnements ionisants, p. ex. pour focaliser ou pour modérer utilisant la diffraction, la réfraction ou la réflexion, p. ex. monochromateurs
G21K 5/02 - Dispositifs d'irradiation n'ayant aucun moyen pour former le faisceau
G21K 5/10 - Dispositifs d'irradiation pourvus de dispositions permettant un mouvement relatif entre la source du rayonnement et l'objet à irradier
Provided is a system comprising a management server, a robot, and a sensor that measures an environment including a space of an action range of the robot. The management server is provided with: a reception unit that receives a mission; and a command unit that generates a command on the basis of the mission and transmits the command to the robot. The command includes a first command representing a state after execution of the mission. The robot is provided with: a state specification unit that specifies an environmental state of the robot including a state of an article handled by the robot on the basis of measurement data of the sensor; and an instruction unit that receives the command and drives the robot so that the state of the robot approaches a state represented by the command on the basis of the difference between the specified state and the state represented by the command.
A feature extraction device extract features of a target from a plurality of images related to the target. The image processor calculates, using an image model, a likelihood of the inputted image belonging to a first image class, and a feature parameter of the inputted image. A feature processor that inputs an image included in the inputted image group into the image processor to calculate the likelihood and the feature parameter, selects, based on the calculated likelihood, a predetermined number of representative images from the inputted image group, and outputs, as feature information of the image group, the feature parameter calculated for the selected predetermined number of representative images. A classification processor is an additional element, inputs a target image group related to a target to the feature processor, and predicts, from the outputted feature information and using a classification model, whether the target belongs to a first target class. Here, an image belonging to the first image class corresponds to the target belonging to the first target class.
G06V 10/764 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant la classification, p. ex. des objets vidéo
G06V 10/77 - Traitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
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