09 - Appareils et instruments scientifiques et électriques
Produits et services
Computer software and hardware for managing, integrating, monitoring, controlling, storing, analyzing and reporting data from environmental monitoring instruments; computer software and hardware for data management and process control for use in the field of facility monitoring
2.
POLYDISPERSED PARTICLE CHALLENGE SAMPLE VOLUME CALIBRATION OF OPTICAL PARTICLE COUNTERS
A method of calibrating an optical particle counter may include performing first and second calibration procedures. The first calibration procedure may include performing sensitivity calibration and/or channel size calibration of the optical particle counter under calibration using a monodispersed particle standard. The second calibration procedure may include sample volume calibration. The sample volume calibration may include: flowing a polydispersed particle calibration sample dispersed in a fluid through the optical particle counter under calibration to produce a first signal output; flowing the polydispersed particle calibration sample dispersed in the fluid through a reference optical particle counter to produce a reference signal output; comparing the first signal output with the reference signal output; and adjusting, in response to the comparing, an effective sample volume parameter stored in a computer readable memory of the optical particle counter under calibration.
A method of calibrating an optical particle counter may include performing first and second calibration procedures. The first calibration procedure may include performing sensitivity calibration and/or channel size calibration of the optical particle counter under calibration using a monodispersed particle standard. The second calibration procedure may include sample volume calibration. The sample volume calibration may include: flowing a polydispersed particle calibration sample dispersed in a fluid through the optical particle counter under calibration to produce a first signal output; flowing the polydispersed particle calibration sample dispersed in the fluid through a reference optical particle counter to produce a reference signal output; comparing the first signal output with the reference signal output; and adjusting, in response to the comparing, an effective sample volume parameter stored in a computer readable memory of the optical particle counter under calibration.
The present invention relates to interferometric detection of particles and optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided exhibiting enhanced alignment and stability for interferometric detection of particles and/or optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided that include compensation means for mitigating the impact of internal and external stimuli and changes in operating conditions that can degrade the sensitivity and reliability of particle detection via optical methods, including interferometric-based techniques and/or systems for optical detection of particles having size dimensions less than or equal to 100 nm.
Provided herein are systems and methods for sampling of controlled environments, including automated and/or robotically controlled sampling. The present systems and methods are useful for determining the presence of, quantity, size, concentration, viability, species or characteristics of particles, including viable biological particles, within a controlled environment. The described systems and methods may utilize rotational motion via robotics, automation and/or control systems to reduce, or eliminate, some or all of the steps carried out by human operators in traditional particle collection and/or analysis methodologies. The described systems and methods may rotational motion via robotics, automation and/or control systems to provide for particle sampling over time periods that are well-defined for an individual impactor and/or sequential sampling via a plurality of impactors.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
6.
ROBOTIC CONTROL FOR PARTICLE SAMPLING AND MONITORING
Provided herein are systems and methods for sampling of controlled environments, including automated and/or robotically controlled sampling. The present systems and methods are useful for determining the presence of, quantity, size, concentration, viability, species or characteristics of particles, including viable biological particles, within a controlled environment. The described systems and methods may utilize rotational motion via robotics, automation and/or control systems to reduce, or eliminate, some or all of the steps carried out by human operators in traditional particle collection and/or analysis methodologies. The described systems and methods may rotational motion via robotics, automation and/or control systems to provide for particle sampling over time periods that are well-defined for an individual impactor and/or sequential sampling via a plurality of impactors.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 15/0205 - Recherche de la dimension ou de la distribution des dimensions des particules par des moyens optiques
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 1/02 - Dispositifs pour prélever des échantillons
7.
PARTICLE SAMPLING SYSTEMS AND METHODS FOR ROBOTIC CONTROLLED MANUFACTURING BARRIER SYSTEMS
Provided herein are systems and methods allowing for automated sampling and/or analysis of controlled environments, for example, to determine the presence, quantity, size, concentration, viability, species or characteristics of particles within the environment. The described systems and methods may utilize robotics or automation or remove some or all of the collection or analysis steps that are traditionally performed by human operators. The methods and systems described herein are versatile and may be used with known particle sampling and analysis techniques and particle detection devices including, for example, optical particle counters, impingers and impactors.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 1/02 - Dispositifs pour prélever des échantillons
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/075 - Recherche de la concentration des suspensions de particules par des moyens optiques
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
Devices and methods for sampling, detecting and/or characterizing particles, for example, via collection, growth and analysis of viable biological particles such as microorganisms. Devices and methods of the invention include particle samplers and impactors including a sampling head comprising one or more intake apertures, a selectively removable cover, an impactor base connected to the sampling head, and one or more magnets fixed to the sampling head, the selectively removable cover and/or the impactor base. The one or more magnets allow for robotic manipulation of the impactor devices.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
An optical system for particle size and concentration analysis, includes: at least one laser that produces an illuminating beam; a focusing lens that focuses the illuminating beam on particles that move relative to the illuminating beam at known or pre-defined angles to the illuminating beam through the focal region of the focusing lens; and at least two forward-looking detectors, that detect interactions of particles with the illuminating beam in the focal region of the focusing lens. The focusing lens is a cylindrical lens that forms a focal region that is: (i) narrow in the direction of relative motion between the particles and the illuminating beam, and (ii) wide in a direction perpendicular to a plane defined by an optical axis of the system and the direction of relative motion between the particles and the illuminating beam. Each of the two forward-looking detectors is comprised of two segmented linear arrays of detectors.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Particle detectors for detecting airborne particles; biological detectors for detecting airborne biological organisms; instrumentation, namely, particle detectors for detecting, counting or sizing of contaminant particles and biological organisms, including airborne autofluorescent particles and inert particles; real-time particle monitors for airborne contaminants and biologics, including real-time inert particle monitors and real-time biological monitors; biofluorescent particle (BFP) detection systems measuring auto-fluorescent units (AFU).
11.
ENHANCED DUAL-PASS AND MULTI-PASS PARTICLE DETECTION
A particle detection system may include a light source, a first beam splitter, a particle interrogation zone, a reflecting surface, a second beam splitter, a first photodetector, and a second photodetector. The first beam splitter may be configured to split the source beam into an interrogation beam and a reference beam. The particle interrogation zone may be disposed in the path of the interrogation beam. The reflecting surface may be configured to reflect the interrogation beam back on itself. The second beam splitter may be configured to: (i) receive the reference beam and side scattered light from one or more particles interacting with the interrogation beam in the particle interrogation zone; and (ii) produce a first component beam and second component beam. The first photodetector may be configured to detect the first component beam. The second photodetector may be configured to detect the second component beam.
A particle detection system may include a light source, a first beam splitter, a particle interrogation zone, a reflecting surface, a second beam splitter, a first photodetector, and a second photodetector. The first beam splitter may be configured to split the source beam into an interrogation beam and a reference beam. The particle interrogation zone may be disposed in the path of the interrogation beam. The reflecting surface may be configured to reflect the interrogation beam back on itself. The second beam splitter may be configured to: (i) receive the reference beam and side scattered light from one or more particles interacting with the interrogation beam in the particle interrogation zone; and (ii) produce a first component beam and second component beam. The first photodetector may be configured to detect the first component beam. The second photodetector may be configured to detect the second component beam.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
G01N 21/63 - Systèmes dans lesquels le matériau analysé est excité de façon à ce qu'il émette de la lumière ou qu'il produise un changement de la longueur d'onde de la lumière incidente excité optiquement
G01N 21/94 - Recherche de souillures, p. ex. de poussières
13.
User access-restrictive systems and methods for operating particle sampling devices
Systems, methods, devices and software for operating particle sampling devices in a user-restrictive manner include a tag and a particle sampling device. The device includes a tag reader and a processor in communication with the tag reader. The processor: receives device configuration data and reads operational and/or user data from the tag having that data encoded thereon. Based on the data read from the tag, the processor may either grant or deny access to a user for performing device operations. Alternatively, for a headless particle sampling device configured for minimal user interaction during operation, the device is removably attached to a supporting structure proximate the tag positioned in or on the supporting structure. In the headless configuration, the processor reads device configuration parameters including network communication information from the tag following device power up. Embodiments of the disclosure facilitate various efficiency improvements for manufacturing operations reliant on particle sampling devices.
H04W 12/47 - Dispositions de sécurité utilisant des modules d’identité utilisant la communication en champ proche [NFC] ou des modules d’identification par radiofréquence [RFID]
H04W 12/63 - Sécurité dépendant du contexte dépendant de la localisationSécurité dépendant du contexte dépendant de la proximité
09 - Appareils et instruments scientifiques et électriques
Produits et services
Particle detectors for detecting airborne particles; biological detectors for detecting airborne biological organisms; instrumentation, namely, particle detectors for detecting, counting or sizing of contaminant particles and biological organisms, including airborne autofluorescent particles and inert particles; real-time particle monitors for airborne contaminants and biologics, including real-time inert particle monitors and real-time biological monitors; biofluorescent particle (BFP) sensors and detectors that measure auto-fluorescent units
15.
OPTICAL ISOLATOR STABILIZED LASER OPTICAL PARTICLE DETECTOR SYSTEMS AND METHODS
A particle detection system may include a laser optical source providing a beam of electromagnetic radiation, one or more beam shaping elements for receiving the beam of electromagnetic radiation, an optical isolator disposed in the path of the beam, a particle interrogation zone disposed in the path of the beam, wherein particles in the particle interrogation zone interact with the beam of electromagnetic radiation, and a first photodetector configured to detect light scattered and/or transmitted from the particle and a controller configured to adjust the beam power based on a signal from the second photodetector, wherein the optical isolator is configured to filter optical feedback.
A particle detection system may include a laser optical source providing a beam of electromagnetic radiation, one or more beam shaping elements for receiving the beam of electromagnetic radiation, an optical isolator disposed in the path of the beam, between the laser source and the one or more beam shaping elements, a particle interrogation zone disposed in the path of the beam, wherein particles in the particle interrogation zone interact with the beam of electromagnetic radiation, and a first photodetector configured to detect light scattered and/or transmitted from the particle interrogation zone, a second photodetector configured to monitor power of the beam, and a controller configured to adjust the beam power based on a signal from the second photodetector, wherein the optical isolator is configured to filter optical feedback from the particle detection system out of an optical path leading to the second photodetector. The particle detection system may be configured to have a lower detection limit of 5 nm to 50 nm effective particle diameter. The laser optical source may have a laser power of 300 milliwatts to 100 watts.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G02F 1/09 - Dispositifs ou dispositions pour la commande de l'intensité, de la couleur, de la phase, de la polarisation ou de la direction de la lumière arrivant d'une source lumineuse indépendante, p. ex. commutation, ouverture de porte ou modulationOptique non linéaire pour la commande de l'intensité, de la phase, de la polarisation ou de la couleur basés sur des éléments magnéto-optiques, p. ex. produisant un effet Faraday
Disclosed is a liquid impinger, for example a liquid impinger, particularly a disposable liquid impinger. The liquid impinger comprises, for example, at least one nozzle positioned in the interior and attached to the bottom portion. In some aspects, the liquid impinger comprises a polymeric material. Also disclosed are methods of making the liquid impinger comprising, for example, forming at least two components, assembling the at least two components into the liquid impinger, filling the liquid impinger with liquid, and exposing the filled liquid impinger to radiation for sterilization prior to use. Also disclosed are methods of using the liquid impinger, for example, by transporting a gas comprising analytes through the liquid impinger and transferring at least a portion of the analytes from the gas into the liquid contained therein. The method further comprises, for example, after transferring analytes form the gas into the liquid, incubating and/or detecting at least a portion of the analytes in the liquid without removing the liquid from the liquid impinger.
Disclosed is a liquid impinger, for example a liquid impinger, particularly a disposable liquid impinger. The liquid impinger comprises, for example, at least one nozzle positioned in the interior and attached to the bottom portion. In some aspects, the liquid impinger comprises a polymeric material. Also disclosed are methods of making the liquid impinger comprising, for example, forming at least two components, assembling the at least two components into the liquid impinger, filling the liquid impinger with liquid, and exposing the filled liquid impinger to radiation for sterilization prior to use. Also disclosed are methods of using the liquid impinger, for example, by transporting a gas comprising analytes through the liquid impinger and transferring at least a portion of the analytes from the gas into the liquid contained therein. The method further comprises, for example, after transferring analytes form the gas into the liquid, incubating and/or detecting at least a portion of the analytes in the liquid without removing the liquid from the liquid impinger.
Disclosed is a method for detecting and/or growing particles, comprising controlling the surface area exposed to the saturator region by monitoring at least one of a depth of the working liquid on the saturator surface, the surface area exposed to the saturator region, or a volume of the working liquid on the saturator surface. Also disclosed is an apparatus or system for detecting and/or growing particles, comprising a fluidics system configured to control the surface area exposed to the saturator region by monitoring at least one of a depth of the working liquid on the saturator surface, the surface area exposed to the saturator region, or a volume of the working liquid on the saturator surface. Certain aspects do not employ one or more porous structures for vapor generation, nor a separate carrier fluid flow or inlet comprising a carrier fluid and vaporized working liquid for combining with the sample flow in the saturator region.
F25J 3/08 - Séparation des impuretés gazeuses des gaz ou des mélanges gazeux
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/06 - Recherche de la concentration des suspensions de particules
B05C 3/02 - Appareillages dans lesquels un ouvrage est mis en contact avec une grande quantité de liquide ou autre matériau fluide l'ouvrage étant immergé dans le liquide ou autre matériau fluide
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
B01D 47/05 - Séparation de particules dispersées dans l'air, des gaz ou des vapeurs en utilisant un liquide comme agent de séparation par condensation de l'agent de séparation
B01D 53/18 - Unités d'absorptionDistributeurs de liquides
Modular docking station and methods for sampling and monitoring gas and other fluids, where a sampling device is able to be removably attached to the docking station, thereby allowing the sampling device to be replaced without having to remove or disconnect the docking station from the rest of the sampling system. This allows the docking station to remain connected to the rest of the system with minimal or no interruption and reduces maintenance costs and time when replacing the sampling device.
A manifold system and methods of collecting samples, where the manifold system comprises multiple input sample ports and a preferably rotatable flow focusing element. The manifold system is able to sample aerosols and gases from multiple sample points, such as from cleanrooms and manufacturing environments, for collection and analysis. The flow focusing element reduces cross talk and cross contamination of particles, including nanoparticles, between different samples.
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
Disclosed is a method for detecting and/or growing particles, comprising controlling the surface area exposed to the saturator region by monitoring at least one of a depth of the working liquid on the saturator surface, the surface area exposed to the saturator region, or a volume of the working liquid on the saturator surface. Also disclosed is an apparatus or system for detecting and/or growing particles, comprising a fluidics system configured to control the surface area exposed to the saturator region by monitoring at least one of a depth of the working liquid on the saturator surface, the surface area exposed to the saturator region, or a volume of the working liquid on the saturator surface. Certain aspects do not employ one or more porous structures for vapor generation, nor a separate carrier fluid flow or inlet comprising a carrier fluid and vaporized working liquid for combining with the sample flow in the saturator region.
A manifold system and methods of collecting samples, where the manifold system comprises multiple input sample ports and a preferably rotatable flow focusing element. The manifold system is able to sample aerosols and gases from multiple sample points, such as from cleanrooms and manufacturing environments, for collection and analysis. The flow focusing element reduces cross talk and cross contamination of particles, including nanoparticles, between different samples.
Modular docking station and methods for sampling and monitoring gas and other fluids, where a sampling device is able to be removably attached to the docking station, thereby allowing the sampling device to be replaced without having to remove or disconnect the docking station from the rest of the sampling system. This allows the docking station to remain connected to the rest of the system with minimal or no interruption and reduces maintenance costs and time when replacing the sampling device.
G01N 21/3504 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant la lumière infrarouge pour l'analyse des gaz, p. ex. analyse de mélanges de gaz
G01N 21/39 - CouleurPropriétés spectrales, c.-à-d. comparaison de l'effet du matériau sur la lumière pour plusieurs longueurs d'ondes ou plusieurs bandes de longueurs d'ondes différentes en recherchant l'effet relatif du matériau pour les longueurs d'ondes caractéristiques d'éléments ou de molécules spécifiques, p. ex. spectrométrie d'absorption atomique en utilisant des lasers à longueur d'onde réglable
25.
Particle sampling systems and methods for robotic controlled manufacturing barrier systems
Provided herein are systems and methods allowing for automated sampling and/or analysis of controlled environments, for example, to determine the presence, quantity, size, concentration, viability, species or characteristics of particles within the environment. The described systems and methods may utilize robotics or automation or remove some or all of the collection or analysis steps that are traditionally performed by human operators. The methods and systems described herein are versatile and may be used with known particle sampling and analysis techniques and particle detection devices including, for example, optical particle counters, impingers and impactors.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 1/02 - Dispositifs pour prélever des échantillons
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
26.
DETECTION SCHEME FOR PARTICLE SIZE AND CONCENTRATION MEASUREMENT
The present invention provides a system and method of particle size and concentration measurement that comprises the steps of: providing a focused, synthesized, structured laser beam, causing the beam to interact with the particles, measuring the interaction signal and the number of interactions per unit time of the beam with the particles, and using algorithms to map the interaction signals to the particle size and the number of interactions per unit time to the concentration.
Provided herein are optical systems and methods for detecting and characterizing particles. Systems and method are provided which increase the sensitivity of an optical particle counter and allow for detection of smaller particles while analyzing a larger fluid volume. The described systems and methods allow for sensitive and accurate detection and size characterization of nanoscale particles (e.g., less than 50 nm, optionally less than 20 nm, optionally less than 10 nm) for large volumes of analyzed fluids.
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
09 - Appareils et instruments scientifiques et électriques
37 - Services de construction; extraction minière; installation et réparation
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer software and hardware for use in sensing,
monitoring, and analyzing various solid, liquid and gaseous
contaminants; software and hardware for counting contaminant
particles; software and hardware for monitoring polishing
and planarization slurries; software and hardware for
continuous monitoring of hydrogen peroxide concentrations;
cleanliness testing stations comprised in part of computer
hardware, computer software, or computer peripherals. Installation, maintenance and repair services, namely,
installation, maintenance and repair of computer hardware
for: sensing, monitoring, and analyzing various solid,
liquid and gaseous contaminants. Education and training services, namely, offering training
programs and seminars tailored to the operation,
maintenance, repair and calibration of systems for: sensing,
monitoring, and analyzing various solid, liquid and gaseous
contaminants. Installation, maintenance and repair services, namely,
installation, maintenance and repair of computer software
for: sensing, monitoring, and analyzing various solid,
liquid and gaseous contaminants; sensing, monitoring, and
analyzing hydrogen peroxide concentrations; counting
contaminant particles; monitoring polishing and
planarization slurries; and cleanliness testing; development
of computer programs for manufacturing process
characterization and design relating to contaminants,
cleanliness, and hydrogen peroxide concentrations;
development of computer programs for trouble shooting of
manufacturing processes relating to contaminants,
cleanliness, and hydrogen peroxide concentrations;
development of computer programs for design of product
validity procedures, testing methods and techniques related
to contaminants, cleanliness, and hydrogen peroxide
concentrations; development of computer programs for
manufacturing site surveys related to contaminants,
cleanliness, and hydrogen peroxide concentrations;
development of computer programs for on-site testing for
contaminants, cleanliness, and hydrogen peroxide
concentrations; development of computer programs for
microcontamination testing services; development of computer
programs for laboratory testing for contaminants,
cleanliness and hydrogen peroxide concentrations; sensing,
monitoring, and analyzing hydrogen peroxide concentrations;
counting contaminant particles; monitoring polishing and
planarization slurries; and cleanliness testing; sensing,
monitoring, and analyzing hydrogen peroxide concentrations;
counting contaminant particles; monitoring polishing and
planarization slurries; and cleanliness testing.
29.
Calibration verification for optical particle analyzers
Provided are particle analyzers and related methods for verifying calibration status of the particle analyzer, including independently of the presence or absence of particles. The method and analyzers include use of distinct and non-interfering time frequency domains: a middle frequency time domain and a low frequency time domain, and optionally a high frequency time domain. The high frequency time domain generates a laser facet drive current frequency modulation to prevent the laser facet from spatial-mode hopping. The middle frequency time domain is for particle detection. The low frequency time domain is for calibration status, including laser-pulse-light self-diagnostics, for the health or calibration status of the analyzer. By carefully selecting the frequency time domain ranges, there is non-interference, with the ability to self-diagnose the instrument that is particle-independent.
Particle detection systems and methods are disclosed. In one embodiment, a particle detection system comprises an incident beam light source that emits an incident beam, a particle interrogation zone disposed in the path of the incident beam, a photodetector disposed to detect the incident beam after passing through the particle interrogation zone, a pump beam light source for emitting a pump beam, the pump beam being targeted at the particle interrogation zone, wherein the incident beam, the pump beam, and photodetector are arranged such that the photodetector is configured to detect a combination of light from the incident beam, scattered light due to incident beam scattering in the particle interrogation zone, and scattered light due to pump beam scattering in the particle interrogation zone.
Particle detection systems and methods are disclosed. In one embodiment, a particle detection system comprises an incident beam light source that emits an incident beam, a particle interrogation zone disposed in the path of the incident beam, a photodetector disposed to detect the incident beam after passing through the particle interrogation zone, a pump beam light source for emitting a pump beam, the pump beam being targeted at the particle interrogation zone, wherein the incident beam, the pump beam, and photodetector are arranged such that the photodetector is configured to detect a combination of light from the incident beam, scattered light due to incident beam scattering in the particle interrogation zone, and scattered light due to pump beam scattering in the particle interrogation zone.
The invention generally provides devices and methods for particle detection for minimizing human-caused contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Methods of the invention may incorporate wirelessly transmitting an alarm signal from a particle detector to a remote device, replicating a graphical user interface of the particle detector on an electronic display of the remote device, and passing one or more user instructions from the remote device to the particle detector via the replicate graphical interface of the remote device.
Devices and methods for sampling, detecting and/or characterizing particles, for example, via collection, growth and analysis of viable biological particles such as microorganisms. Devices and methods of the invention include particle samplers and impactors including a sampling head comprising one or more intake apertures, a selectively removable cover, an impactor base connected to the sampling head, and one or more magnets fixed to the sampling head, the selectively removable cover and/or the impactor base. The one or more magnets allow for robotic manipulation of the impactor devices.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
G01N 1/20 - Dispositifs pour prélever des échantillons à l'état liquide ou fluide pour matériau coulant ou s'éboulant
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 21/95 - Recherche de la présence de criques, de défauts ou de souillures caractérisée par le matériau ou la forme de l'objet à analyser
G01N 33/579 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir un lysat de limulus
Devices and methods for sampling, detecting and/or characterizing particles, for example, via collection, growth and analysis of viable biological particles such as microorganisms. Devices and methods of the invention include particle samplers and impactors including a sampling head comprising one or more intake apertures, a selectively removable cover, an impactor base connected to the sampling head, and one or more magnets fixed to the sampling head, the selectively removable cover and/or the impactor base. The one or more magnets allow for robotic manipulation of the impactor devices.
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
C12Q 1/04 - Détermination de la présence ou du type de micro-organismeEmploi de milieux sélectifs pour tester des antibiotiques ou des bactéricidesCompositions à cet effet contenant un indicateur chimique
The present invention relates to interferometric detection of particles and optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided exhibiting enhanced alignment and stability for interferometric detection of particles and/or optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided that include compensation means for mitigating the impact of internal and external stimuli and changes in operating conditions that can degrade the sensitivity and reliability of particle detection via optical methods, including interferometric-based techniques and/or systems for optical detection of particles having size dimensions less than or equal to 100 nm.
Provided herein are particle detection systems, and related methods configured to characterize a liquid sample, comprising: a first probe configured to determine a first parameter set of a plurality of first particles in a liquid sample, the first particles characterized by a size characteristic selected from a first size range; wherein the first parameter set comprises a first size distribution and a first concentration; and a second probe configured to determine a second parameter set of one or more second particles in the liquid sample, the second particles being characterized by a size characteristic selected from a second size range; wherein the second parameter set comprises a second size distribution and a second concentration.
The present invention relates to interferometric detection of particles and optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided exhibiting enhanced alignment and stability for interferometric detection of particles and/or optical detection of particles having size dimensions less than or equal to 100 nm. Systems and methods are provided that include compensation means for mitigating the impact of internal and external stimuli and changes in operating conditions that can degrade the sensitivity and reliability of particle detection via optical methods, including interferometric-based techniques and/or systems for optical detection of particles having size dimensions less than or equal to 100 nm.
Provided are particle analyzers and related methods for verifying calibration status of the particle analyzer, including independently of the presence or absence of particles. The method and analyzers include use of distinct and non-interfering time frequency domains: a middle frequency time domain and a low frequency time domain, and optionally a high frequency time domain. The high frequency time domain generates a laser facet drive current frequency modulation to prevent the laser facet from spatial-mode hopping. The middle frequency time domain is for particle detection. The low frequency time domain is for calibration status, including laser-pulse-light self-diagnostics, for the health or calibration status of the analyzer. By carefully selecting the frequency time domain ranges, there is non-interference, with the ability to self-diagnose the instrument that is particle-independent.
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
09 - Appareils et instruments scientifiques et électriques
37 - Services de construction; extraction minière; installation et réparation
Produits et services
Air contamination particle counters; Aerosol manifold particle counters for monitoring airborne particles Installation, repair and maintenance of particle counters
43.
MOBILE MONITORING DEVICE FOR CONTROLLED CONTAMINATION AREAS
A mobile monitoring device for monitoring controlled contamination areas may include a motorized mobile structure, a sampling unit, and a central management and control unit. The motorized mobile structure is configured to move within an area to be monitored. The sampling unit is positioned on said mobile structure, and configured to perform sampling operations of air and/or surfaces of said area and obtain sampling data. The central management and control unit is operatively connected to the mobile structure and to said sampling unit. The mobile structure may be controlled by the central unit to reach predefined points of the area to be monitored. The sampling unit may be selectively activated and/or deactivated by said central unit in correspondence with said predefined starting points of said sampling operations
G05D 1/00 - Commande de la position, du cap, de l'altitude ou de l'attitude des véhicules terrestres, aquatiques, aériens ou spatiaux, p. ex. utilisant des pilotes automatiques
A47L 9/28 - Montage de l'équipement électrique, p. ex. adaptation ou fixation à l'aspirateurCommande des aspirateurs par des moyens électriques
44.
Detecting nanoparticles on production equipment and surfaces
Provided herein is a particle analyzer that is operably connected to a probe unit that is capable of both dislodging particles from a surface and sampling the particles after they have been dislodged. The devices and methods described herein may be lightweight and/or handheld, for example, so that they may be used within a cleanroom environment to clean and sample permanent surfaces and tools. The devices may include optical particle counters that use scattered, obscured or emitted light to detect particles, including condensation particle counting systems or split detection optical particle counters to increase the sensitivity of the device and thereby facilitate detection of smaller particles, while avoiding the increased complexity typically required for the detection of nanoscale particles, such as particles less than 100 nm in effective diameter.
B82Y 35/00 - Procédés ou appareils pour la mesure ou l’analyse des nanostructures
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
45.
Mobile monitoring device for controlled contamination areas
A mobile monitoring device for monitoring controlled contamination areas may include a motorized mobile structure, a sampling unit, and a central management and control unit. The motorized mobile structure is configured to move within an area to be monitored. The sampling unit is positioned on said mobile structure, and configured to perform sampling operations of air and/or surfaces of said area and obtain sampling data. The central management and control unit is operatively connected to the mobile structure and to said sampling unit. The mobile structure may be controlled by the central unit to reach predefined points of the area to be monitored. The sampling unit may be selectively activated and/or deactivated by said central unit in correspondence with said predefined starting points of said sampling operations.
The invention generally provides devices and methods for particle detection for minimizing human-caused contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Methods of the invention may incorporate wirelessly transmitting an alarm signal from a particle detector to a remote device, replicating a graphical user interface of the particle detector on an electronic display of the remote device, and passing one or more user instructions from the remote device to the particle detector via the replicate graphical interface of the remote device
G06F 3/048 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI]
G08B 19/00 - Alarmes réagissant à plusieurs conditions différentes, indésirables ou anormales, p. ex. cambriolage et incendie, température anormale et débit d'écoulement anormal
G06F 3/041 - Numériseurs, p. ex. pour des écrans ou des pavés tactiles, caractérisés par les moyens de transduction
The invention generally provides systems and methods for particle detection for minimizing microbial growth and cross-contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. In some embodiments, systems of the invention incorporate a housing having an outer surface being a first antimicrobial surface and a touchscreen being a second antimicrobial surface. In some embodiments, substantially all of the outer surfaces of the system are antimicrobial surfaces. In some embodiments, the first antimicrobial surface may comprise an Active Screen Plasma alloyed layer. In some embodiments, the housing may comprise a molded polymer substrate and a metal coating layer bonded to the molded polymer substrate such that at least some exterior surfaces of the housing are metal coated surfaces.
B05D 5/00 - Procédés pour appliquer des liquides ou d'autres matériaux fluides aux surfaces pour obtenir des effets, finis ou des structures de surface particuliers
B32B 7/02 - Propriétés physiques, chimiques ou physicochimiques
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
The invention generally provides systems and methods for particle detection for minimizing microbial growth and cross-contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. In some embodiments, systems of the invention incorporate a housing having an outer surface being a first antimicrobial surface and a touchscreen being a second antimicrobial surface. In some embodiments, substantially all of the outer surfaces of the system are antimicrobial surfaces. In some embodiments, the first antimicrobial surface may comprise an Active Screen Plasma alloyed layer. In some embodiments, the housing may comprise a molded polymer substrate and a metal coating layer bonded to the molded polymer substrate such that at least some exterior surfaces of the housing are metal coated surfaces.
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
49.
Particle detectors with remote alarm monitoring and control
The invention generally provides devices and methods for particle detection for minimizing human-caused contamination in manufacturing environments requiring low levels of microbes, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Methods of the invention may incorporate wirelessly transmitting an alarm signal from a particle detector to a remote device, replicating a graphical user interface of the particle detector on an electronic display of the remote device, and passing one or more user instructions from the remote device to the particle detector via the replicate graphical interface of the remote device.
Described herein are monitoring systems and methods, including for airborne molecular contamination (AMC), that combine a sampler, such as an impinger or sorbent tube with a real time analyzer, such as an ion mobility spectrometer (IMS) or optical particle counter. The system may allow for selective sampling in which the sampler is only exposed to the target fluid during periods in which the real time analyzer detects analytes, such as molecular contamination or particles, meeting particular criteria such the composition and/or concentration of analytes. The invention also includes impinger systems having a sampler reservoir comprising an anion leaching resistant material characterized by low anion leach rates in the presence of deionized water.
Described herein are monitoring systems and methods, including for airborne molecular contamination (AMC), that combine a sampler, such as an impinger or sorbent tube with a real time analyzer, such as an ion mobility spectrometer (IMS) or optical particle counter. The system may allow for selective sampling in which the sampler is only exposed to the target fluid during periods in which the real time analyzer detects analytes, such as molecular contamination or particles, meeting particular criteria such the composition and/or concentration of analytes. The invention also includes impinger systems having a sampler reservoir comprising an anion leaching resistant material characterized by low anion leach rates in the presence of deionized water.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 1/02 - Dispositifs pour prélever des échantillons
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
52.
USER ACCESS-RESTRICTIVE SYSTEMS AND METHODS FOR OPERATING PARTICLE SAMPLING DEVICES
Systems, methods, devices and software for operating particle sampling devices in a user-restrictive manner include a tag and a particle sampling device. The device includes a tag reader and a processor in communication with the tag reader. The processor: receives device configuration data and reads operational and/or user data from the tag having that data encoded thereon. Based on the data read from the tag, the processor may either grant or deny access to a user for performing device operations. Alternatively, for a headless particle sampling device configured for minimal user interaction during operation, the device is removably attached to a supporting structure proximate the tag positioned in or on the supporting structure. In the headless configuration, the processor reads device configuration parameters including network communication information from the tag following device power up. Embodiments of the disclosure facilitate various efficiency improvements for manufacturing operations reliant on particle sampling devices.
Systems, methods, devices and software for operating particle sampling devices in a user-restrictive manner include a tag and a particle sampling device. The device includes a tag reader and a processor in communication with the tag reader. The processor: receives device configuration data and reads operational and/or user data from the tag having that data encoded thereon. Based on the data read from the tag, the processor may either grant or deny access to a user for performing device operations. Alternatively, for a headless particle sampling device configured for minimal user interaction during operation, the device is removably attached to a supporting structure proximate the tag positioned in or on the supporting structure. In the headless configuration, the processor reads device configuration parameters including network communication information from the tag following device power up. Embodiments of the disclosure facilitate various efficiency improvements for manufacturing operations reliant on particle sampling devices.
H04W 12/00 - Dispositions de sécuritéAuthentificationProtection de la confidentialité ou de l'anonymat
H04W 12/033 - Protection de la confidentialité, p. ex. par chiffrement du plan utilisateur, p. ex. trafic utilisateur
H04W 12/47 - Dispositions de sécurité utilisant des modules d’identité utilisant la communication en champ proche [NFC] ou des modules d’identification par radiofréquence [RFID]
H04W 12/63 - Sécurité dépendant du contexte dépendant de la localisationSécurité dépendant du contexte dépendant de la proximité
Provided herein are optical systems and methods for detecting and characterizing particles. Systems and method are provided which increase the sensitivity of an optical particle counter and allow for detection of smaller particles while analyzing a larger fluid volume. The described systems and methods allow for sensitive and accurate detection and size characterization of nanoscale particles (e.g., less than 50 nm, optionally less than 20 nm, optionally less than 10 nm) for large volumes of analyzed fluids.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
56.
PARTICLE DETECTION SYSTEMS AND METHODS FOR ON-AXIS PARTICLE DETECTION AND/OR DIFFERENTIAL DETECTION
Provided herein are optical systems and methods for detecting and characterizing particles. Systems and method are provided which increase the sensitivity of an optical particle counter and allow for detection of smaller particles while analyzing a larger fluid volume. The described systems and methods allow for sensitive and accurate detection and size characterization of nanoscale particles (e.g., less than 50 nm, optionally less than 20 nm, optionally less than 10 nm) for large volumes of analyzed fluids.
An optical system for particle size and concentration analysis, includes: at least one laser that produces an illuminating beam; a focusing lens that focuses the illuminating beam on particles that move relative to the illuminating beam at known or pre-defined angles to the illuminating beam through the focal region of the focusing lens; and at least two forward-looking detectors, that detect interactions of particles with the illuminating beam in the focal region of the focusing lens. The focusing lens is a cylindrical lens that forms a focal region that is: (i) narrow in the direction of relative motion between the particles and the illuminating beam, and (ii) wide in a direction perpendicular to a plane defined by an optical axis of the system and the direction of relative motion between the particles and the illuminating beam. Each of the two forward-looking detectors is comprised of two segmented linear arrays of detectors.
37 - Services de construction; extraction minière; installation et réparation
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Installation, maintenance and repair services, namely, installation, maintenance and repair of computer hardware for sensing, monitoring, and analyzing various solids, liquid and gaseous contaminants, and hydrogen peroxide concentrations, counting contaminant particles, monitoring of polishing and planarization slurries, and cleanliness testing Education and training services, namely, offering training programs and seminars tailored to the operation, maintenance, repair and calibration of systems for sensing, monitoring, and analyzing various solid, liquid and gaseous contaminants, and hydrogen peroxide concentrations, counting contaminant particles, monitoring of polishing and planarization slurries, and cleanliness testing Installation, maintenance and repair services, namely, installation, maintenance and repair of computer software for sensing, monitoring, and analyzing various solid, liquid and gaseous contaminants, and hydrogen peroxide concentrations, counting contaminant particles, monitoring of polishing and planarization slurries, and cleanliness testing; development of computer programs for manufacturing process characterization and design relating to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for trouble shooting of manufacturing processes relating to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for design of product validity procedures, testing methods and techniques related to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for manufacturing site surveys related to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for on-site testing for contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for microcontamination testing; development of computer programs for laboratory testing for contaminants, cleanliness and hydrogen peroxide concentrations
Provided herein are systems and methods allowing for automated sampling and/or analysis of controlled environments, for example, to determine the presence, quantity, size, concentration, viability, species or characteristics of particles within the environment. The described systems and methods may utilize robotics or automation or remove some or all of the collection or analysis steps that are traditionally performed by human operators. The methods and systems described herein are versatile and may be used with known particle sampling and analysis techniques and particle detection devices including, for example, optical particle counters, impingers and impactors.
Provided are particle analyzers and related methods for verifying calibration status of the particle analyzer. The method includes the steps of providing an optical particle analyzer and modulating a power applied to a source of EMR. The method includes the steps of, in response to the modulating step, inducing a detector signal waveform and analyzing the detector signal waveform to determine a value of at least one diagnostic parameter associated with one or more of the source of EMR, an optical assembly, a chamber, a detector, and an optical collection system of the optical particle analyzer. The method includes the step of determining a calibration status of the optical particle analyzer based on the one or more determined values of the at least one diagnostic parameter.
Provided herein are particle detection systems, and related methods configured to characterize a liquid sample, comprising: a first probe configured to determine a first parameter set of a plurality of first particles in a liquid sample, the first particles characterized by a size characteristic selected from a first size range; wherein the first parameter set comprises a first size distribution and a first concentration; and a second probe configured to determine a second parameter set of one or more second particles in the liquid sample, the second particles being characterized by a size characteristic selected from a second size range; wherein the second parameter set comprises a second size distribution and a second concentration.
Provided herein are systems and methods allowing for automated sampling and/or analysis of controlled environments, for example, to determine the presence, quantity, size, concentration, viability, species or characteristics of particles within the environment. The described systems and methods may utilize robotics or automation or remove some or all of the collection or analysis steps that are traditionally performed by human operators. The methods and systems described herein are versatile and may be used with known particle sampling and analysis techniques and particle detection devices including, for example, optical particle counters, impingers and impactors.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
64.
Slurry monitor coupling bulk size distribution and single particle detection
Provided herein are particle detection systems, and related methods configured to characterize a liquid sample, comprising: a first probe configured to determine a first parameter set of a plurality of first particles in a liquid sample, the first particles characterized by a size characteristic selected from a first size range; wherein the first parameter set comprises a first size distribution and a first concentration; and a second probe configured to determine a second parameter set of one or more second particles in the liquid sample, the second particles being characterized by a size characteristic selected from a second size range; wherein the second parameter set comprises a second size distribution and a second concentration.
Provided are particle analyzers and related methods for verifying calibration status of the particle analyzer. The method includes the steps of providing an optical particle analyzer and modulating a power applied to a source of EMR. The method includes the steps of, in response to the modulating step, inducing a detector signal waveform and analyzing the detector signal waveform to determine a value of at least one diagnostic parameter associated with one or more of the source of EMR, an optical assembly, a chamber, a detector, and an optical collection system of the optical particle analyzer. The method includes the step of determining a calibration status of the optical particle analyzer based on the one or more determined values of the at least one diagnostic parameter.
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/06 - Recherche de la concentration des suspensions de particules
H01S 3/00 - Lasers, c.-à-d. dispositifs utilisant l'émission stimulée de rayonnement électromagnétique dans la gamme de l’infrarouge, du visible ou de l’ultraviolet
66.
DETECTING NANOPARTICLES ON PRODUCTION EQUIPMENT AND SURFACES
Provided herein is a particle analyzer that is operably connected to a probe unit that is capable of both dislodging particles from a surface and sampling the particles after they have been dislodged. The devices and methods described herein may be lightweight and/or handheld, for example, so that they may be used within a cleanroom environment to clean and sample permanent surfaces and tools. The devices may include optical particle counters that use scattered, obscured or emitted light to detect particles, including condensation particle counting systems or split detection optical particle counters to increase the sensitivity of the device and thereby facilitate detection of smaller particles, while avoiding the increased complexity typically required for the detection of nanoscale particles, such as particles less than 100 nm in effective diameter.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c.-à-d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
67.
Fluid refractive index optimizing particle counter
Provided herein are systems and methods of optical particle counters which account and adjust for the refractive index of the carrier fluid being analyzed. The provided systems are robust and may be implemented in a variety of optical particle counters including obscured light, reflected light, emitted light and scattered light particle counters. The described systems may be useful with any fluid, including gases or liquids. In some cases, the system can account for the differences in refractive index between two liquids, for example, ultrapure water and an acid, such as sulfuric, hydrochloric, hydrofluoric, acetic, phosphoric, chromic phosphoric, and the like. By accounting for the refractive index of the carrier fluid, the described systems and methods are also more sensitive and able to more accurately detect and characterize smaller particles, including nanoscale sized particles.
Provided herein is a particle analyzer that is operably connected to a probe unit that is capable of both dislodging particles from a surface and sampling the particles after they have been dislodged. The devices and methods described herein may be lightweight and/or handheld, for example, so that they may be used within a cleanroom environment to clean and sample permanent surfaces and tools. The devices may include optical particle counters that use scattered, obscured or emitted light to detect particles, including condensation particle counting systems or split detection optical particle counters to increase the sensitivity of the device and thereby facilitate detection of smaller particles, while avoiding the increased complexity typically required for the detection of nanoscale particles, such as particles less than 100 nm in effective diameter.
B82Y 35/00 - Procédés ou appareils pour la mesure ou l’analyse des nanostructures
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
69.
FLUID REFRACTIVE INDEX OPTIMIZING PARTICLE COUNTER
Provided herein are systems and methods of optical particle counters which account and adjust for the refractive index of the carrier fluid being analyzed. The provided systems are robust and may be implemented in a variety of optical particle counters including obscured light, reflected light, emitted light and scattered light particle counters. The described systems may be useful with any fluid, including gases or liquids. In some cases, the system can account for the differences in refractive index between two liquids, for example, ultrapure water and an acid, such as sulfuric, hydrochloric, hydrofluoric, acetic, phosphoric, chromic phosphoric, and the like. By accounting for the refractive index of the carrier fluid, the described systems and methods are also more sensitive and able to more accurately detect and characterize smaller particles, including nanoscale sized particles.
09 - Appareils et instruments scientifiques et électriques
Produits et services
(1) Particle detectors for detecting airborne particles; biological detectors for detecting airborne biological organisms; instrumentation, namely, particle detectors for detecting, counting, sizing and combinations of detecting, counting, and sizing of contaminant particles and biological organisms, namely airborne autofluorescent particles and inert particles; real-time particle monitors for airborne contaminants and biologics, namely real-time inert particle monitors and real-time biological monitors; biofluorescent particle (BFP) detection systems measuring auto-fluorescent units (AFU).
71.
Microbial air sampler integrating media plate and sample collection device
The invention generally provides devices and methods for sampling, detecting and/or characterizing particles, for example, via collection, growth and analysis of viable biological particles such as microorganisms. Devices and methods of the invention include particle samplers and impactors for collecting and/or analyzing biological particles in manufacturing environments requiring low levels of particles, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Devices and methods of the invention incorporate an integrated sampler and impact surface, such as the receiving surface of a growth media, in a manner to minimize, or entirely eliminate, risks associated with user handling, such as the occurrence of false positive determinations due to contamination of the impact surface during particle sampling, growth or analysis processes.
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/12 - Appareillage pour l'enzymologie ou la microbiologie avec des moyens de stérilisation, filtration ou dialyse
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
72.
Automatic power control liquid particle counter with flow and bubble detection systems
The systems and methods provided herein relate generally to the improvement of data quality in optical liquid particle counters and control of optical particle counters to achieve longer expected lifetime, for example by avoiding damage caused by electromagnetic radiation and heat. The systems and methods incorporate sensors which characterize the fluid flowing through the flow cell, thereby enhancing accuracy and reducing the number of false positives.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01F 1/704 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu utilisant des zones marquées ou non homogènes de l’écoulement de fluide, p. ex. des variations statistiques d'un paramètre du fluide
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
H05B 47/105 - Commande de la source lumineuse en réponse à des paramètres détectés
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
73.
Firmware design for facility navigation, and area and location data management of particle sampling and analysis instruments
Provided herein are methods and devices that allow for efficient management of many different sampling locations within a facility. A method for operating a biological sampler, a particle counter, and like air sampling, analysis, and/or monitoring equipment or instrumentation is described, such as by sampling an environment at a sampling position with the biological sampler and storing sample data and other useful information in memory in association with unique identifier(s) including sampling location(s) for the samples. Also provided are associated devices for carrying out the methods.
G06F 3/0484 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] pour la commande de fonctions ou d’opérations spécifiques, p. ex. sélection ou transformation d’un objet, d’une image ou d’un élément de texte affiché, détermination d’une valeur de paramètre ou sélection d’une plage de valeurs
G06F 3/0482 - Interaction avec des listes d’éléments sélectionnables, p. ex. des menus
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01C 21/20 - Instruments pour effectuer des calculs de navigation
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G06F 3/0488 - Techniques d’interaction fondées sur les interfaces utilisateur graphiques [GUI] utilisant des caractéristiques spécifiques fournies par le périphérique d’entrée, p. ex. des fonctions commandées par la rotation d’une souris à deux capteurs, ou par la nature du périphérique d’entrée, p. ex. des gestes en fonction de la pression exercée enregistrée par une tablette numérique utilisant un écran tactile ou une tablette numérique, p. ex. entrée de commandes par des tracés gestuels
G01N 35/00 - Analyse automatique non limitée à des procédés ou à des matériaux spécifiés dans un seul des groupes Manipulation de matériaux à cet effet
G01N 1/02 - Dispositifs pour prélever des échantillons
G06F 3/04842 - Sélection des objets affichés ou des éléments de texte affichés
An optical system for particle size and concentration analysis, includes: at least one laser that produces an illuminating beam; a focusing lens that focuses the illuminating beam on particles that move relative to the illuminating beam at known or pre-defined angles to the illuminating beam through the focal region of the focusing lens; and at least two forward- looking detectors, that detect interactions of particles with the illuminating beam in the focal region of the focusing lens. The focusing lens is a cylindrical lens that forms a focal region that is: (i) narrow in the direction of relative motion between the particles and the illuminating beam, and (ii) wide in a direction perpendicular to a plane defined by an optical axis of the system and the direction of relative motion between the particles and the illuminating beam. Each of the two forward-looking detectors is comprised of two segmented linear arrays of detectors.
09 - Appareils et instruments scientifiques et électriques
Produits et services
software for environmental monitoring applications, including within the pharmaceutical industry; software to analyze and manage data from particle detectors, counters, or analyzers; software for real-time trending, automated investigations and root cause analysis to facilitate identification of high risk areas in production processes and to assist in a risk scoring process
Apparatuses for increasing the effective size of gas-entrained particles in a particle detector are disclosed. In one embodiment, an apparatus comprises an evaporation chamber, a condenser in fluid communication with the evaporation chamber, and an inlet in fluid communication with the condenser for receiving a stream of sample gas containing gas-entrained particles. The evaporation chamber includes a heating element and a porous support surrounding the heating element. The porous support carries thereon a working fluid, and the heating element vaporizes the working fluid to form vapor within the evaporation chamber. The porous support may include a portion which extends into a working fluid reservoir.
B05C 3/00 - Appareillages dans lesquels un ouvrage est mis en contact avec une grande quantité de liquide ou autre matériau fluide
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
B01D 5/00 - Condensation de vapeursRécupération de solvants volatils par condensation
G01N 15/06 - Recherche de la concentration des suspensions de particules
B05C 3/02 - Appareillages dans lesquels un ouvrage est mis en contact avec une grande quantité de liquide ou autre matériau fluide l'ouvrage étant immergé dans le liquide ou autre matériau fluide
G01N 33/00 - Recherche ou analyse des matériaux par des méthodes spécifiques non couvertes par les groupes
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
77.
Automatic power control liquid particle counter with flow and bubble detection systems
The systems and methods provided herein relate generally to the improvement of data quality in optical liquid particle counters and control of optical particle counters to achieve longer expected lifetime, for example by avoiding damage caused by electromagnetic radiation and heat. The systems and methods incorporate sensors which characterize the fluid flowing through the flow cell, thereby enhancing accuracy and reducing the number of false positives.
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01F 1/704 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu utilisant des zones marquées ou non homogènes de l’écoulement de fluide, p. ex. des variations statistiques d'un paramètre du fluide
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
The systems and methods provided herein relate generally to the prevention of migration of condensate in a condensation particle counter between components designed to handle condensate (e.g. saturator, condenser, condensate reservoir) and components which may be damaged by the condensate (e.g. detection and flow control devices).
G01N 1/00 - ÉchantillonnagePréparation des éprouvettes pour la recherche
G01N 15/06 - Recherche de la concentration des suspensions de particules
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
79.
SYSTEMS AND METHODS FOR ISOLATING CONDENSATE IN A CONDENSATION PARTICLE COUNTER
The systems and methods provided herein relate generally to the prevention of migration of condensate in a condensation particle counter between components designed to handle condensate (e.g. saturator, condenser, condensate reservoir) and components which may be damaged by the condensate (e.g. detection and flow control devices).
B01D 53/18 - Unités d'absorptionDistributeurs de liquides
B01D 47/05 - Séparation de particules dispersées dans l'air, des gaz ou des vapeurs en utilisant un liquide comme agent de séparation par condensation de l'agent de séparation
B05C 3/02 - Appareillages dans lesquels un ouvrage est mis en contact avec une grande quantité de liquide ou autre matériau fluide l'ouvrage étant immergé dans le liquide ou autre matériau fluide
F25J 3/08 - Séparation des impuretés gazeuses des gaz ou des mélanges gazeux
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/06 - Recherche de la concentration des suspensions de particules
G05D 23/22 - Commande de la température caractérisée par l'utilisation de moyens électriques avec un élément sensible présentant une variation de ses propriétés électriques ou magnétiques avec les changements de température l'élément sensible étant un thermocouple
G05D 23/24 - Commande de la température caractérisée par l'utilisation de moyens électriques avec un élément sensible présentant une variation de ses propriétés électriques ou magnétiques avec les changements de température l'élément sensible ayant une résistance variant avec la température, p. ex. une thermistance
80.
AUTOMATIC POWER CONTROL LIQUID PARTICLE COUNTER WITH FLOW AND BUBBLE DETECTION SYSTEMS
The systems and methods provided herein relate generally to the improvement of data quality in optical liquid particle counters and control of optical particle counters to achieve longer expected lifetime, for example by avoiding damage caused by electromagnetic radiation and heat. The systems and methods incorporate sensors which characterize the fluid flowing through the flow cell, thereby enhancing accuracy and reducing the number of false positives.
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 21/49 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide
G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
B01J 19/12 - Procédés utilisant l'application directe de l'énergie ondulatoire ou électrique, ou un rayonnement particulaireAppareils à cet usage utilisant des radiations électromagnétiques
81.
Active filtration system for controlling cleanroom environments
This invention is in the field of systems and methods for controlling contamination in high purity environments. This invention relates generally to particulate filtering and treatment of molecular contamination and process gases in enclosures, such as cleanrooms, contamination controlled manufacturing environments, mini-environments, isolators, glove boxes and restricted air barrier systems (RABS). The invention is capable of chemically transforming molecular contamination and process gases into less reactive or inert reaction products while at the same time decreasing the level of biological and nonbiological particulates.
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
B01D 53/82 - Procédés en phase solide avec des réactifs à l'état stationnaire
A61L 9/12 - Appareils, p. ex. supports, à cet effet
B01D 53/72 - Composés organiques non prévus dans les groupes , p. ex. hydrocarbures
B01D 53/32 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par effets électriques autres que ceux prévus au groupe
A61L 9/00 - Désinfection, stérilisation ou désodorisation de l'air
B01D 53/46 - Élimination des composants de structure définie
The present invention provides a system and method of particle size and concentration measurement that comprises the steps of: providing a focused, synthesized, structured laser beam, causing the beam to interact with the particles, measuring the interaction signal and the number of interactions per unit time of the beam with the particles, and using algorithms to map the interaction signals to the particle size and the number of interactions per unit time to the concentration.
G01N 15/10 - Recherche de particules individuelles
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
84.
Laser noise detection and mitigation in particle counting instruments
This invention relates to optical particle counters and methods capable of effectively distinguishing signals generated from particle light scattering from sources of noise. Embodiments of the invention, for example, use multisensory detector configurations for identifying and distinguishing signals corresponding to fluctuations in laser intensity from signals corresponding to particle light scattering for the detection and characterization of submicron particles. In an embodiment, for example, methods and systems of the invention compare signals from different detector elements of a detector array to identify and characterize noise events, such as noise generated from laser intensity instability, thereby allow for the detection and characterization of smaller particles. The system and methods of the present invention, thus, provide an effective means of reducing false positives caused by noise or interference while allowing for very sensitive particle detection.
G01N 21/00 - Recherche ou analyse des matériaux par l'utilisation de moyens optiques, c.-à-d. en utilisant des ondes submillimétriques, de la lumière infrarouge, visible ou ultraviolette
G01N 21/53 - Dispersion, c.-à-d. réflexion diffuse dans un corps ou dans un fluide dans un courant de fluide, p. ex. dans la fumée
G01N 15/14 - Techniques de recherche optique, p. ex. cytométrie en flux
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
G01N 15/10 - Recherche de particules individuelles
85.
LASER NOISE DETECTION AND MITIGATION IN PARTICLE COUNTING INSTRUMENTS
This invention relates to optical particle counters and methods capable of effectively distinguishing signals generated from particle light scattering from sources of noise. Embodiments of the invention, for example, use multisensory detector configurations for identifying and distinguishing signals corresponding to fluctuations in laser intensity from signals corresponding to particle light scattering for the detection and characterization of submicron particles. In an embodiment, for example, methods and systems of the invention compare signals from different detector elements of a detector array to identify and characterize noise events, such as noise generated from laser intensity instability, thereby allow for the detection and characterization of smaller particles. The system and methods of the present invention, thus, provide an effective means of reducing false positives caused by noise or interference while allowing for very sensitive particle detection.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Scientific apparatus for diagnostic testing of biological
samples, namely, reagents and devices for the detection and
characterization of biological contaminants on surfaces for
use in life sciences clean room and manufacturing
applications.
This invention is in the field of systems and methods for controlling contamination in high purity environments. This invention relates generally to particulate filtering and treatment of molecular contamination and process gases in enclosures, such as cleanrooms, contamination controlled manufacturing environments, mini-environments, isolators, glove boxes and restricted air barrier systems (RABS). The invention is capable of chemically transforming molecular contamination and process gases into less reactive or inert reaction products while at the same time decreasing the level of biological and nonbiological particulates.
B01D 53/46 - Élimination des composants de structure définie
A61L 2/00 - Procédés ou appareils de désinfection ou de stérilisation de matériaux ou d'objets autres que les denrées alimentaires ou les lentilles de contactAccessoires à cet effet
A61L 9/00 - Désinfection, stérilisation ou désodorisation de l'air
B01D 53/32 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par effets électriques autres que ceux prévus au groupe
B01D 53/72 - Composés organiques non prévus dans les groupes , p. ex. hydrocarbures
88.
ACTIVE FILTRATION SYSTEM FOR CONTROLLING CLEANROOM ENVIRONMENTS
This invention is in the field of systems and methods for controlling contamination in high purity environments. This invention relates generally to particulate filtering and treatment of molecular contamination and process gases in enclosures, such as cleanrooms, contamination controlled manufacturing environments, mini-environments, isolators, glove boxes and restricted air barrier systems (RABS). The invention is capable of chemically transforming molecular contamination and process gases into less reactive or inert reaction products while at the same time decreasing the level of biological and nonbiological particulates.
F24F 3/16 - Systèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par purification, p. ex. par filtrageSystèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par stérilisationSystèmes de conditionnement d'air dans lesquels l'air conditionné primaire est fourni par une ou plusieurs stations centrales aux blocs de distribution situés dans les pièces ou enceintes, blocs dans lesquels il peut subir un traitement secondaireAppareillage spécialement conçu pour de tels systèmes caractérisés par le traitement de l'air autrement que par chauffage et refroidissement par ozonisation
F24F 7/06 - Ventilation avec réseau de gaines à circulation d'air forcée, p. ex. par un ventilateur
The invention provides devices and methods for sampling, detecting and/or characterizing particles. Devices and methods of the invention, including particle samplers, impactors and counters, include a filter component for removing particles in the exhaust flow of the device, for example, to eliminate or minimize the potential for the device itself to provide source of particles in an environment undergoing particle monitoring. This aspect of the present devices and methods is particularly useful for monitoring particles in manufacturing environments requiring low levels of particles, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products.
Provided are systems and methods for accurate sensing of particle concentrations in fluids by employing a particle impactor system that allows for collection, growth and analysis of biological particles. The disclosed systems and methods make use of a pressure based flow sensor which permits the particle impactor system systems to accurately and reliably provide measurements of biological particle concentrations in the ambient environment. By incorporation of pressure sensors and pressure measurements into the flow measurement techniques, embodiments provide for the ability to use a particle impactor system to accurately measure environmental biological particle concentrations at a variety of atmospheric pressure conditions, such as at high altitude or with minimal perturbation from atmospheric weather conditions, without requiring recalibration or other adjustment of the sensors and control systems.
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01F 1/34 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques en mesurant la pression ou la différence de pression
G01F 1/28 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques par détection des effets dynamiques de l’écoulement par débitmètre à force d'entraînement, p. ex. du type à palette ou à poussée
G01F 1/76 - Dispositifs pour mesurer le débit massique d'un fluide ou d'un matériau solide fluent
G01F 1/36 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques en mesurant la pression ou la différence de pression la pression ou la différence de pression étant produite par une contraction de la veine fluide
Provided are systems and methods for accurate sensing of particle concentrations in fluids by employing a particle impactor system that allows for collection, growth and analysis of biological particles. The disclosed systems and methods make use of a pressure based flow sensor which permits the particle impactor system systems to accurately and reliably provide measurements of biological particle concentrations in the ambient environment. By incorporation of pressure sensors and pressure measurements into the flow measurement techniques, embodiments provide for the ability to use a particle impactor system to accurately measure environmental biological particle concentrations at a variety of atmospheric pressure conditions, such as at high altitude or with minimal perturbation from atmospheric weather conditions, without requiring recalibration or other adjustment of the sensors and control systems.
G01F 1/28 - Mesure du débit volumétrique ou du débit massique d'un fluide ou d'un matériau solide fluent, dans laquelle le fluide passe à travers un compteur par un écoulement continu en utilisant des effets mécaniques par détection des effets dynamiques de l’écoulement par débitmètre à force d'entraînement, p. ex. du type à palette ou à poussée
G01F 1/76 - Dispositifs pour mesurer le débit massique d'un fluide ou d'un matériau solide fluent
92.
Particle impactor with selective height adjustment
Provided are impactors for detecting biologics having an adjustable separation distance between an impact surface and the intake aperture, including the exit of the intake aperture. The impactor has a sampling head having at least one intake aperture and an exit, an impactor base comprising an impact surface, wherein the impact surface opposibly faces the sampling head exit and is separated from the exit by a separation distance. The separation distance is continuously adjustable between a minimum separation distance and a maximum separation distance and can accommodate impact surfaces having different heights by positioning the impact surface, irrespective of height of the impact surface, at an optimal separation distance from the sample intake aperture, such as by a rotation-type mechanism with a change in distance indication provided to a user by a separation distance step indicator.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
The invention provides devices and methods for sampling, detecting and/or characterizing particles. Devices and methods of the invention, including particle samplers, impactors and counters, include a filter component for removing particles in the exhaust flow of the device, for example, to eliminate or minimize the potential for the device itself to provide source of particles in an environment undergoing particle monitoring. This aspect of the present devices and methods is particularly useful for monitoring particles in manufacturing environments requiring low levels of particles, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products.
Provided are impactors for detecting biologics having an adjustable separation distance between an impact surface and the intake aperture, including the exit of the intake aperture. The impactor has a sampling head having at least one intake aperture and an exit, an impactor base comprising an impact surface, wherein the impact surface opposibly faces the sampling head exit and is separated from the exit by a separation distance. The separation distance is continuously adjustable between a minimum separation distance and a maximum separation distance and can accommodate impact surfaces having different heights by positioning the impact surface, irrespective of height of the impact surface, at an optimal separation distance from the sample intake aperture, such as by a rotation-type mechanism with a change in distance indication provided to a user by a separation distance step indicator.
Provided herein are methods and devices that allow for efficient management of many different sampling locations within a facility. A method for operating a biological sampler is described, such as by sampling an environment at a sampling position with the biological sampler and associating the sampling position with a unique identifier, wherein the unique identifier comprises an area and a location. Also provided are associated devices for carrying out the methods.
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
B01D 45/08 - Séparation de particules dispersées dans des gaz ou des vapeurs par gravité, inertie ou force centrifuge par inertie par projection contre les diaphragmes séparateurs
09 - Appareils et instruments scientifiques et électriques
37 - Services de construction; extraction minière; installation et réparation
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Computer software and hardware for use in sensing, monitoring and analyzing various solid, liquid and gaseous contaminants; software and hardware for counting contaminant particles; software and hardware for monitoring polishing and planarization slurries; software and hardware for continuous monitoring of hydrogen peroxide concentrations; cleanliness testing stations comprised in part of computer hardware, computer software, or computer peripherals. Installation, maintenance and repair services, namely, installation, maintenance and repair of computer hardware for: sensing, monitoring, and analyzing various solid, liquid and gaseous contaminants, sensing, monitoring, and analyzing hydrogen peroxide concentrations, counting contaminant particles, monitoring polishing and planarization slurries, and cleanliness testing. Education and training services, namely, offering training programs and seminars tailored to the operation, maintenance, repair and calibration of systems for: sensing, monitoring, and analyzing various solid, liquid and gaseous contaminants, sensing, monitoring, and analyzing hydrogen peroxide concentrations, counting contaminant particles, monitoring polishing and planarization slurries, and cleanliness testing. Installation, maintenance and repair services, namely, installation, maintenance and repair of computer software for: sensing, monitoring, and analyzing various solid, liquid and gaseous contaminants, sensing, monitoring, and analyzing hydrogen peroxide concentrations, counting contaminant particles, monitoring polishing and planarization slurries, and cleanliness testing; development of computer programs for manufacturing process characterization and design relating to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for trouble shooting of manufacturing processes relating to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for design of product validity procedures, testing methods and techniques related to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for manufacturing site surveys related to contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for on-site testing for contaminants, cleanliness, and hydrogen peroxide concentrations; development of computer programs for microcontamination testing services; development of computer programs for laboratory testing for contaminants, cleanliness and hydrogen peroxide concentrations.
97.
Microbial air sampler integrating media plate and sample collection device
The invention generally provides devices and methods for sampling, detecting and/or characterizing particles, for example, via collection, growth and analysis of viable biological particles such as microorganisms. Devices and methods of the invention include particle samplers and impactors for collecting and/or analyzing biological particles in manufacturing environments requiring low levels of particles, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Devices and methods of the invention incorporate an integrated sampler and impact surface, such as the receiving surface of a growth media, in a manner to minimize, or entirely eliminate, risks associated with user handling, such as the occurrence of false positive determinations due to contamination of the impact surface during particle sampling, growth or analysis processes.
09 - Appareils et instruments scientifiques et électriques
Produits et services
Computer hardware for use in sensing, monitoring, and analyzing various solid, liquid and gaseous contaminants; computer hardware for use in counting contaminant particles; computer hardware for monitoring polishing and planarization slurries; computer hardware for continuous monitoring of hydrogen peroxide concentrations; cleanliness testing stations comprised in part of computer hardware or computer peripherals
The invention generally provides devices and methods for sampling, detecting and/or characterizing particles, for example, via collection, growth and analysis of viable biological particles such as microorganisms. Devices and methods of the invention include particle samplers and impactors for collecting and/or analyzing biological particles in manufacturing environments requiring low levels of particles, such as cleanroom environments for electronics manufacturing and aseptic environments for manufacturing pharmaceutical and biological products, such as sterile medicinal products. Devices and methods of the invention incorporate an integrated sampler and impact surface, such as the receiving surface of a growth media, in a manner to minimize, or entirely eliminate, risks associated with user handling, such as the occurrence of false positive determinations due to contamination of the impact surface during particle sampling, growth or analysis processes.
The invention provides a method for obtaining aerosol particle size distributions with a scanning mobility particle sizer (SMPS) device comprising a differential mobility analyzer (DMA); which method comprises the stages: (i) collecting a first data set of particle concentrations vs. size for a size range from a predetermined minimal size Dmin to an intermediate size Dt by varying a voltage applied to a DMA column of an SMPS from Vmin to Vt1 at a first sheath flow rate Qsh1; (ii) changing the sheath flow rate from the first sheath flow rate Qsh1 to a second sheath flow rate Qsh2; (iii) collecting a second data set of particle concentrations vs. size for a size range from the intermediate size Dt to a predetermined maximum size Dmax by varying the voltage applied to the DMA column of the SMPS from Vt2 to Vmax at the second sheath flow rate Qsh2; (iv) convolving the first data set from stage (i) using an apparatus function of the DMA and the sheath flow rates Qsh1 and Qsh2 in stage (ii); (v) combining the convolved data set from stage (iv) with the second data set from stage (iii) to form a merged data set corresponding to the size distribution from Dmin to Dmax; and (vi) deconvolving the merged data set to provide a size distribution for the full size range Dmin to Dmax. Also provided are a DMA, SMPS or Fast Mobility Particle Sizer (FMPS) apparatus set up to perform the method.
G01N 1/22 - Dispositifs pour prélever des échantillons à l'état gazeux
G01N 15/02 - Recherche de la dimension ou de la distribution des dimensions des particules
G01N 27/62 - Recherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant l'ionisation des gaz, p. ex. des aérosolsRecherche ou analyse des matériaux par l'emploi de moyens électriques, électrochimiques ou magnétiques en recherchant les décharges électriques, p. ex. l'émission cathodique
G01N 15/00 - Recherche de caractéristiques de particulesRecherche de la perméabilité, du volume des pores ou de l'aire superficielle effective de matériaux poreux
