Abstract

The present disclosure provides a novel synthetic intermediate of prostaglandin or an optically active substance thereof, and a production method that uses the same. More specifically, in the method according to the present disclosure for producing prostaglandin or an optically active substance thereof, a compound represented by any of general formulas (I) through (IV) or an optically active substance thereof is used as the synthetic intermediate.

IPC Classes  ?

• C07C 317/18 - SulfonesSulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
• C07C 45/64 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by introduction of functional groups containing oxygen only in singly bound form
• C07C 49/707 - Unsaturated compounds containing a keto group being part of a ring containing hydroxy groups a keto group being part of a three- to five-membered ring
• C07C 67/14 - Preparation of carboxylic acid esters from carboxylic acid halides
• C07C 69/63 - Halogen-containing esters of saturated acids
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
• C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
• C07D 295/26 - Sulfur atoms
• C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

Abstract

The present disclosure provides: a novel synthesis intermediate for beraprost or an optically active form thereof; and a production method using the synthesis intermediate. More specifically, in the present disclosure, a compound represented by general formula (I) or (II) or an optically active form thereof is used as a synthesis intermediate in the production of beraprost or an optically active form thereof.

IPC Classes  ?

• C07D 307/93 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
• A61K 31/343 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
• A61P 11/00 - Drugs for disorders of the respiratory system
• C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

Abstract

The present invention provides: industrially desirable and novel optically-active cyclopentenone derivatives; and a novel industrial manufacturing method. The novel optically-active cyclopentenone derivatives and method for manufacturing the same are, respectively: an intermediate for industrially desirable and novel prostaglandin derivatives and the like; and a method for manufacturing the same. It is expected that the present invention will be commercialized and industrialized.

IPC Classes  ?

• C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
• C07B 51/00 - Introduction of protecting groups or activating groups, not provided for in groups
• C07B 63/02 - PurificationSeparation specially adapted for the purpose of recovering organic compoundsStabilisationUse of additives by treatment giving rise to a chemical modification
• C12P 7/38 - Cyclopentanone- or cyclopentadione- containing products

Abstract

The present invention provides: industrially desirable and novel optically-active cyclopentenone derivatives; and a novel industrial manufacturing method. The novel optically-active cyclopentenone derivatives and method for manufacturing the same are, respectively: an intermediate for industrially desirable and novel prostaglandin derivatives and the like; and a method for manufacturing the same. It is expected that the present invention will be commercialized and industrialized.

IPC Classes  ?

• C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
• C12P 7/26 - Ketones

Abstract

A sulfenamide vulcanization accelerator is provided that acts satisfactorily slowly on a vulcanization reaction, produces no carcinogenic nitrosamine, and is free from environmental hygiene problems such as bioaccumulation. Also provided is an N-alkyl-N-t-butylbenzothiazole-2-sulfenamide represented by formula [I]. The vulcanization accelerator is a vulcanization accelerator for rubber, containing this compound. Furthermore provided is a process for producing the vulcanization accelerator. wherein R represents methyl, ethyl, n-propyl, or n-butyl.

IPC Classes  ?

• C07D 277/80 - Sulfur atoms attached to a second hetero atom to a nitrogen atom

Abstract

A sulfonamide-based vulcanization accelerator is provided which acts sufficiently slowly on a vulcanization reaction, generates no carcinogenic nitrosamine, and is free from hygienic or environmental problems such as bioaccumulation. Also provided is an N-alkyl-N-t-butylbenzothiazole-2-sulfenamide represented by formula (I). The vulcanization accelerator for rubbers contains this compound. Furthermore provided is a process for producing the same. [Chemical formula 1] [R represents methyl, ethyl, n-propyl, or n-butyl.]

IPC Classes  ?

• C07D 277/80 - Sulfur atoms attached to a second hetero atom to a nitrogen atom
• C08K 5/47 - Thiazoles
• C08L 21/00 - Compositions of unspecified rubbers