The present invention relates to the development of a new live fowl typhoid (FT) vaccine candidate against Salmonella Gallinarum (SG), with two independent attenuating mutations based on metabolic drift (MD), spontaneous chromosomal mutations. Such vaccine candidate fulfills the security demand of the World Health Organization (WHO). The vaccine proved to be genetically stable, safe and effective in experimental studies. This attenuated vaccine strain is designed sufficiently invasive to induce immunity in poultry, in particular chickens, and the vaccinated animals were protected against experimental SG challenge. The vaccine can be used for chicken and can be administered orally which is an easy and cost effective alternative to injection.
Described is a method for the generation of a live vaccine containing stable bacteria carrying at least three attenuating mutations and a vaccine containing bacteria obtained by said method.
The invention relates to a new use of antioxidants for improving animal health. In particular, as a result of using antioxidants and also substances with an antioxidative effect, an increase or improvement in the endogenous radical defence system, a reduction in inflammatory processes and/or a prevention of and/or reduction in fertility problems is achieved.
COMPOSITION COMPRISING AN AGENT FOR STABILIZING ACTIVE SUBSTANCES IN DRINKING WATER, EFFERVESCENT MIXTURE, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF
Disclosed is a method for producing saponified, carotenoid-containing oleoresin, in which unsaponified, carotenoid-containing oleoresin is intensely mixed with a solid, small-sized and/or powdery alkali metal hydroxide, and the oleoresin is saponified during said process.