The present disclosure describes a method which outlines a process for conversion of CBD to a Δ9-tetrahydrocannabinol (Δ9-THC) compound or derivative thereof involving treating a naturally produced CBD intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the Δ9-tetrahydrocannabinol compound or derivative thereof at a relatively high concentration. The source of the CBD is from industrial hemp having less than 0.3% Δ9-THC and extracting and purifying a CBD distillate or isolate or a combination thereof. This procedure will produce Δ9-THC that is essentially free from any other cannabinoids other than some trace amounts of the initial CBD starting material, or about 95% Δ9-THC and 2-4% CBD. Another aspect of the present invention relates to a process for further purification and enrichment of the Δ9-THC using distillation and collecting an essentially pure fraction of Δ9-THC using additional distillation or enrichment form of purification. Included are methods and processes to scale the reaction from the lab to large scale manufacturing. Included are methods for adding a molecule marker to authenticate high purity Δ9-THC products. Formulations and uses for pharmaceuticals, nutraceuticals, food products, and topicals are also provided.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
B01D 11/04 - Solvent extraction of solutions which are liquid
B01D 15/08 - Selective adsorption, e.g. chromatography
B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
C07C 37/74 - SeparationPurificationStabilisationUse of additives by physical treatment by distillation
C07D 311/78 - Ring systems having three or more relevant rings
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
B01D 1/08 - Evaporators with vertical tubes with short tubes
B01D 11/04 - Solvent extraction of solutions which are liquid
B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
C07D 311/78 - Ring systems having three or more relevant rings
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
B01D 1/08 - Evaporators with vertical tubes with short tubes
B01D 11/04 - Solvent extraction of solutions which are liquid
B01D 39/20 - Other self-supporting filtering material of inorganic material, e.g. asbestos paper or metallic filtering material of non-woven wires
B01J 31/14 - Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
C07C 37/74 - SeparationPurificationStabilisationUse of additives by physical treatment by distillation
C07D 311/78 - Ring systems having three or more relevant rings
The present invention describes a process to isomerize industrial hemp derived Cannabidiol (CBD) to a pure Δ8-tetrahydrocannabinol (Δ8-THC) extract. This procedure will produce Δ8-tetrahydrocannabinol that is essentially free from any detectable levels of Δ9-tetrahydrocannabinol (Δ9-THC). Included in this filing are methods and processes to scale the reaction from the lab to process to large scale manufacturing. Additionally, the resulting extract from said methods and processes consists of higher purity than previously reported in the art and greater efficiency compared to prior art.
C07B 63/02 - PurificationSeparation specially adapted for the purpose of recovering organic compoundsStabilisationUse of additives by treatment giving rise to a chemical modification
C07B 41/06 - Formation or introduction of functional groups containing oxygen of carbonyl groups
C07B 41/04 - Formation or introduction of functional groups containing oxygen of ether, acetal or ketal groups
C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
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