A syringe pump system (2) comprises: a syringe (4) having a syringe sleeve (6) and a syringe plunger (8) which is movable in the syringe sleeve (6), wherein the syringe sleeve (6) has an opening (71) for receiving and dispensing a fluid; a switchover valve (40) which is fluidically connected to the opening (71) in the syringe sleeve (6); and a syringe pump body (16) which is designed to support the syringe (4) and the switchover valve (40); wherein the syringe pump body (16) has at least one drive (20, 22) which is designed to drive the syringe plunger (8) and/or the switchover valve (40). The switchover valve (40) has a switchover valve data memory (52) in which switchover valve data are stored. A processor (26) is provided in the syringe pump body (16) and is designed to read the switchover valve data from the switchover valve data memory (52). At least one interface (54, 58) is formed between the syringe pump body (16) and the switchover valve (40), which interface makes it possible to transmit the switchover valve data from the switchover valve data memory (52) to the processor (26) in the syringe pump body (16).
The invention relates to a combination sensor (2) for determining the pH value and oxygen content of a liquid (5) to be analysed, in particular in a bioreactor (3), comprising a measuring module (4), a signal processing module (6) and a coupling device (8) for coupling the measuring module (4) and the signal processing module (6) to one other. The measuring module (4) contains at least one optical waveguide (40) and a single-rod measuring chain having a reference half-cell (60) and a measuring half-cell (50), wherein the at least one optical waveguide (40) and the measuring half-cell (50) are arranged within the reference half-cell (60). The signal processing module (6) contains electronic components (41, 42, 44) which are designed to convert light signals transmitted through the optical waveguide (40) into electrical signals in order to make it possible to determine, from the light signals to be transmitted through the optical waveguide (40), the oxygen content of the liquid (5) to be analysed and to process electrical signals which are provided at a measuring electrode (54). The coupling device (8) has a first coupling part (81), which is provided on the measuring module (4), and a complementary second coupling part (82), which is provided on the signal processing module (6), wherein the first coupling part (81) and the second coupling part (82) can be releasably coupled to each other. The coupling device (8) is designed to transmit light signals transmitted through the optical waveguide (40) and electrical signals provided at the measuring electrode (54) from the measuring module (4) to the signal processing module (6) when the first coupling part (81) and the second coupling part (82) are coupled to one other.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/85 - Investigating moving fluids or granular solids
3.
LABORATORY MODULE COMPRISING A DELIVERY TRANSPORT DEVICE WITH TWO DELIVERY RECEIVING DEVICES, EACH OF WHICH IS DESIGNED TO RECEIVE AT LEAST ONE RESPECTIVE LABORATORY OBJECT
The invention relates to a laboratory module (56) comprising a delivery transport device (96), which can be moved along a delivery transport path (98), for transporting at least one laboratory object (158a, 158b, 158c) within the laboratory module (56) along the delivery transport path (98), said delivery transport device (96) having a delivery receiving assembly (104) designed to receive at least one laboratory object (158a, 158b, 158c). According to the invention, the delivery receiving assembly (104) has two delivery receiving devices (104a, 104b), each of which is designed to receive a respective laboratory object (158a, 158b, 158c) for a transport process carried out by means of the delivery transport device (96), wherein the two delivery receiving devices (104a, 104b) can be moved together along the delivery transport path (98).
The invention relates to a laboratory module (56a, 56b, 56c) comprising a transport assembly (99). The transport assembly (99) has a first and a second transport device (68, 96), wherein the first transport device (68) has a first receiving device (72), and the second transport device (96) has a second receiving device (102). The first receiving device (72) can be moved along a transport path (70), and the second receiving device (102) can be moved along a second transport path (98) which differs from the first transport path (70). The transport assembly (99) has a transfer region (176) in which the transport assembly (99) is designed to transfer a laboratory object (158a, 158b, 158c) between the first and second receiving device (72, 102). At least one of the first and second receiving devices (72, 102) can be driven so as to carry out a transfer movement at least in the transfer region (176), and the first and second receiving device (72, 102) can be moved past each other along a relative movement transfer path (TRB) in the transfer region (176). The transfer movement cancels a receiving engagement between the laboratory object (158a, 158b, 158c) and the receiving device which is dispensing the laboratory object and produces a receiving engagement between the laboratory object and the receiving device which is receiving the laboratory object.
The invention concerns a laboratory module rack (36) comprising at least two laboratory base modules (42) at a lower, base module level (38) and at least two laboratory working modules (56) at an upper, working module level (40) arranged above the base module level (38), wherein each laboratory working module (56) comprises a processing device (60) and a conveying assembly (99) having a first and a second conveying device (68, 96) for conveying a laboratory object at least towards the processing device (60), wherein the first conveying device (68) has a first receiving device (72) and the second conveying device (96) has a second receiving device (102) for receiving the laboratory object, for conveying the laboratory object, wherein the conveying assembly (99) has a transfer region (176) in which the conveying assembly (99) is configured to transfer a conveyed laboratory object between the first and second conveying devices (68, 96), wherein the at least two laboratory working modules (56) succeed one another along the direction of movement of the first conveying device (70) and have a common first conveying device (68) and in each case their own second conveying device (96) and in each case their own transfer region (176).
The invention relates to a laboratory module (56), comprising: a) a pipetting device (64) for aspirating and dispensing liquids; b) a set of different laboratory objects (158a, 158b, 158c), comprising a source vessel (158a), a target vessel (158c) and a pipette tip assembly (158b) having at least one pipette tip (184) as different laboratory objects (158a, 158b, 158c); and, c) a delivery transport device (96) which can be moved along a delivery transport path (98) for transporting laboratory objects (158a, 158b, 158c) at least into the working region (186) of the pipetting device (64), wherein the delivery transport device (96) is designed to transport a first sub-selection (157) comprising one or two different laboratory objects (158c), selected from the source vessel (158a), the target vessel (158c) and the pipette tip assembly (158b), from a transfer station (178) of the laboratory module (56) into the working region (186) of the pipetting device (64), and is further designed to transport a second sub-selection (158) comprising a laboratory object (158a, 158b) not contained in the first sub-selection (157), selected from the source vessel (158a), the target vessel (158c) and the pipette tip assembly (158b), from a supply station (182), which is different to the transfer station (178), into the working region (186) of the pipetting device (64).
The present invention relates to an ATR sensor (10) for determining the concentration of glucose in a fluid, comprising a sensor housing (12) in which at least the following sensor components are accommodated: an infrared radiation source (22); an ATR element (24) designed to transmit, with total internal reflection on at least one boundary surface of the ATR element (24), infrared radiation emitted by the infrared radiation source (22); at least one infrared detector (40) designed to sense infrared radiation transmitted by the ATR element (24) and to output a corresponding infrared measurement signal; and at least two infrared bandpass filters (36a, 36b) which are disposed between the ATR element (24) and the infrared detector (40), each of the infrared bandpass filters (36a, 36b) being designed such that it allows only infrared radiation having a wave number within a predefined wave number range (F1, F2) to pass. At a temperature of 37°C, a first of the infrared bandpass filters (36a) allows infrared radiation having a wave number in a first wave number range (F1) from 1005 cm-1to 1025 cm-1to pass. At a temperature of 37°C, a second of the infrared bandpass filters (36b) allows infrared radiation having a wave number in a second wave number range (F2) from 1075 cm-1 to 1095 cm-1 to pass.
G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
8.
SLIM ATR SENSOR WITH A MEASURING AND REFERENCE SIGNAL
An ATR sensor having a sensor housing, wherein at least the following sensor components are accommodated in the sensor housing: an infrared radiation source, an ATR element, wherein the ATR element is designed to transmit infrared radiation via reflection on at least one boundary surface of the ATR element; an infrared measuring sensor which detects infrared radiation emitted by the infrared radiation source after its transmission via the ATR element, and which outputs a measuring detection signal depending on the infrared radiation detected by the infrared measuring sensor; and infrared reference sensor which detects infrared radiation emitted by the infrared radiation source that is not transmitted by the ATR element, and which outputs a reference detection signal depending on the infrared radiation detected by the infrared reference sensor, the infrared radiation source being designed and arranged to radiate an infrared measuring radiation portion detected by the infrared measuring sensor in a measuring radiation direction, and to simultaneously radiate an infrared reference radiation portion detected by the infrared reference sensor in a reference radiation direction that is different to the measuring radiation direction.
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having reaction vessels (88) which are arranged in a matrix pattern in first rows (88a) and second rows (88b), wherein the first rows (88a) are parallel to one another, the second rows (88b) are parallel to one another, and the first and second rows intersect one another, wherein each reaction vessel (88) of the plurality of reaction vessels (88) arranged in a matrix pattern is located at an intersection point of a first and a second row (88a, 88b), wherein each reaction vessel (88) has an inlet port (104) and, at a distance therefrom, an outlet port (116), and ii. a magnetic device (70) having a movable magnet carrier assembly (72), wherein the number of matrix magnets (94) is less than the number of reaction vessels (88) of the plurality of reaction vessels (88), wherein two matrix magnets (94) are adjacent to each reaction vessel (88) of the plurality of reaction vessels (88). The magnet carrier assembly (72) carries a number of matrix magnets (94) that is greater than the sum of the first and second rows (88a, 88b), wherein the matrix magnets (94) each have a polarisation direction (94a) that is nonparallel to both the first rows (88a) and the second rows (88b) and that is non-orthogonal to both the first rows (88a) and the second rows (88b).
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having a reaction vessel assembly (86) with at least one reaction vessel (88), wherein the at least one reaction vessel (88) has an inlet end (102) with an inlet port (104) and an outlet end (106) that is located at a distance from the inlet end (102) and has an outlet port (116), ii. a dosing device (62a) having at least one dosing port (188) for delivering liquid (109) into at least one reaction vessel (88) of the reaction vessel device (18), wherein the dosing device (62a) is designed to deliver liquid via the dosing port (188) through the inlet port (104) in the at least one reaction vessel (88), and iii. a pressure modification device (62b), wherein the pressure modification device (62b) is designed to modify a gas pressure difference between an internal gas pressure in at least one reaction vessel (88) of the reaction vessel device (18) and an external gas pressure outside the at least one reaction vessel (88). The pressure modification device (62b) and the dosing device (62a) together form a combined supply device (62) that can be moved along a supply path (BP) and has: at least one gas outlet opening (190), which is distinct from the dosing port (188), for releasing gas; and the at least one dosing port (188).
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having a reaction vessel assembly (86) with at least one reaction vessel (88), wherein the at least one reaction vessel (88) has an inlet port (104) and, at a distance therefrom, an outlet port (116); ii. a useful-liquid receiving device (50) for receiving liquid dispensed through the outlet port (116) in the at least one reaction vessel (86), iii. a waste-liquid receiving device (46) for receiving liquid discharged through the outlet port (116) in the at least one reaction vessel (86), iv. a magnetic device (70) for generating a magnetic field in the at least one reaction vessel (88), v. a pressure modification device (62b) for modifying a gas pressure in at least one reaction vessel (88), and vi. a dosing device (62a) for delivering liquid (109) into at least one reaction vessel (88) of the reaction vessel device (18). Each of the devices listed in i. to v. is accommodated in an apparatus housing (12) of the liquid handling apparatus (10) so as to be movable relative to each of the other devices listed in i. to v., and each of the devices listed in i. to iv. and vi. is accommodated in the apparatus housing (12) so as to be movable relative to each of the other devices listed in i. to iv. and vi.
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having a reaction vessel holder (20) and at least one reaction vessel (88) for placement in the reaction vessel holder (20), wherein the at least one reaction vessel (88) has an inlet port (104) and, at a distance therefrom, an outlet port (116), ii. a useful-liquid receiving device (50) for receiving liquid dispensed through the outlet port (116) in the at least one reaction vessel (88), iii. a waste-liquid receiving device (46) for receiving liquid discharged through the outlet port (116) in the at least one reaction vessel (88), iv. a pressure modification device (62b), wherein the pressure modification device (62b) is designed to modify the internal gas pressure in at least one reaction vessel (88) of the reaction vessel device (18), v. a dosing device (62a) having at least one dosing opening (188) for delivering liquid (109) into at least one reaction vessel (88) of the reaction vessel device (18), and vi. a control device (40). The automated liquid handling apparatus (10) comprises a container sensor (92) which detects the arrangement of at least one reaction vessel (88) in the reaction vessel holder (20) and outputs a corresponding detection result to the control device (40).
A reaction vessel (88) for an automated liquid handling device extends along a virtual vessel axis (BA) between an input end (102), having an input opening (104), and an output end (106), having an output channel (108), wherein between the input opening (104) and the output channel (108) a receiving volume (112) is formed, wherein the output channel (108) has an inlet opening (114) on its channel end closer to the receiving volume (112) and has an output opening (116) on its channel end closer to the external environment of the reaction vessel (88), wherein the distance (D) to be measured along the vessel axis (BA) between the inlet opening (114) and the input opening (104) forms a reference dimension (RD) of the reaction vessel (88). A second tapering region (112b) has, at least in an inlet portion (126) closer to the inlet opening (114) than to the first tapering region (112a), a second taper angle (α2) in the range from 40° to 50° between the vessel axis (BA) and the inner wall surface (110a) over an axial extent of at least 3 % of the reference dimension (RD).
The invention relates to an automated liquid handling apparatus (10) for handling liquids (109), said apparatus comprising: i. a reaction vessel device (18) having a reaction vessel assembly (86) with a plurality of reaction vessels (88), wherein each reaction vessel (88) of the plurality of reaction vessels (88) has an outlet end (102) with an outlet port (104), ii. a waste-liquid receiving device (46) for receiving liquid discharged through the outlet port (104) in the reaction vessels (88) as handling waste, wherein the waste-liquid receiving device (46) comprises a waste collection container (45) with a receiving volume (45a) for receiving the handling waste from the plurality of reaction vessels (88) and comprises a waste container holder (28), and iii. a pressure modification device (62b), wherein the pressure modification device (62b) is designed to modify a gas pressure difference between an internal gas pressure in at least one reaction vessel (88) of the reaction vessel device (18) and an external gas pressure outside the at least one reaction vessel (88). The waste collection container (45) has a tray body (45c) and a container lid (45d) which is arranged on the tray body and covers at least most of the collection volume (45a) of the waste collection container.
The invention relates to a method for separating HMW DNA and/or UHMW DNA from a carrier member (8), to which the DNA is releasably attached, using a centrifugation container set (2) having at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and at least one collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) is separably plugged on the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) has a container wall (14), which surrounds a container interior (12), and a container base (16) having at least one outflow opening (20), wherein the outflow opening (20) forms at least one flow path (24) from the container interior (12) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel interior (42) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) for a fluid to be centrifuged, wherein the at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and the at least one collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) are geometrically coordinated with one another such that there is a free distance (a) from an outlet opening (22) of the outflow opening (20) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel base (44) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) in the direction of a main extension axis (H1) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h), wherein the free distance (a) is selected such that possible threads of the DNA detach from the outlet opening (22).
A turbidity sensor for detecting clouding of a fluid by particulates contained in the fluid, wherein the turbidity sensor includes a fluid detection region for the reception and metrological detection of fluid; a radiation source for emitting radiation into the fluid detection region; a first radiation sensor for detecting a first part of the radiation emitted by the radiation source; and a second radiation sensor, different from the first radiation sensor, for detecting a second part of the radiation emitted by the radiation source that is different from the first part, wherein at least a portion of the fluid detection region is located between the first radiation sensor and the second radiation sensor, the second radiation sensor is located in a beam path of the first part of the radiation emitted by the radiation source that is detected by the first radiation sensor.
The invention relates to an ATR sensor base assembly (10) comprising: - a measuring range assembly (14) comprising + an ATR element (26) and + a framing component (18) which frames the ATR element (26), wherein the ATR element (26) has a measurement interface (26a) which faces the external surroundings (U) of the measuring range assembly (14) and is accommodated on the framing component (18) in such a way that the measurement interface (26a) is exposed on the measuring range assembly (14) towards the external surroundings (U) of the measuring range assembly (14), - a porous separating component (22) which is designed to be detachably arranged on the measuring range assembly (14) so as to at least partially cover the measurement interface (26a), and - a holding component (20) which is designed to be detachably arranged on the measuring range assembly (14) so as to at least partially cover the porous separating component (22) and, when arranged, to exert a loading force (B) onto the separating component (22), which loading force acts in the direction of the measuring range assembly (14). According to the invention, the ATR sensor base assembly (10) comprises a magnet assembly (31) in such a way that the loading force (B) exerted onto the separating component (22) between the holding component (20) and the measuring range assembly (14) has at least one magnetic force component.
The present invention relates to a method for the quality-assessed metering by means of a pipetting device (10), the method comprising the following steps: - carrying out a metering process by moving a pipetting plunger (30), - recording the time curve of the working-gas pressure (44, 54) in a pipetting channel (12) during the metering process, - comparing the curve of the working-gas pressure (90) on the basis of the recorded time curve of the working-gas pressure (44, 64) with a predetermined target pressure value range (54, 74), and - outputting a quality assessment of the metering process on the basis of the result of the comparison step. According to the invention, in order to improve the quality assessment, the control device (38) carries out the following further steps while the pipetting channel (12) is filled exclusively with working gas as fluid: - carrying out corrective-pressure determination by moving the pipetting plunger (30), and - measuring a pressure of the working gas in the pipetting channel (12) as a corrective pressure during the corrective-pressure determination, wherein, prior to the comparison step, the control device (38) corrects the time curve of the working-gas pressure (44, 64) recorded during the metering process on the basis of the corrective pressure measured during the, so that the comparison step is carried out using the corrected time curve (90) of the working-gas pressure.
Proposed is an exchangeable pipette tip (10; 110; 210), wherein the pipette tip (10; 110; 210) extends along a channel axis (K), wherein the channel axis (K) defines an axial direction (a) running along the channel axis (K), radial directions (r) orthogonal with respect to the channel axis (K), and a circumferential direction (u) encircling the channel axis (K), wherein the pipette tip (10; 110; 210), at one axial longitudinal end thereof forming a coupling longitudinal end (12), has a coupling formation (40) which is designed for coupling to a counterpart coupling formation of a pipette device, wherein the pipette tip (10; 110; 210), at the longitudinal end thereof situated axially opposite the coupling longitudinal end (12) and forming a dosing longitudinal end (14), has a pipette opening (34) that is communicatively connected to a receiving space (36) designed for receiving liquid that is to be dosed, wherein the receiving space (36) of the pipette tip (10; 110; 210) is designed to taper toward the pipette opening (34), characterized in that at least one axial portion of the receiving space (36) is concave and forms a concave axial portion (26), such that an inner wall (11b) of the pipette tip (10; 110; 210) that radially delimits said portion is curved about at least one curvature axis (K3) running transversely with respect to the channel axis (K).
The invention relates to an electrochemical sensor having a porous diaphragm and an electrolyte formulation that comprises at least one solvent, at least one electrolyte from the group of alkali metal salts and at least one alkaline earth metal ion, and to an electrolyte formulation.
The invention relates to an ATR sensor (10) comprising a sensor housing (12), wherein at least the following sensor components are accommodated in the sensor housing (12): an infrared radiation source (22), an ATR element (24), wherein the ATR element (24) is designed to transmit infrared radiation via reflection on at least one boundary surface of the ATR element (24); an infrared measuring sensor (32) which detects infrared radiation emitted by the infrared radiation source (22) after its transmission via the ATR element (24), and which outputs a measuring detection signal depending on the infrared radiation detected by the infrared measuring sensor (32); and infrared reference sensor (34) which detects infrared radiation emitted by the infrared radiation source (22) that is not transmitted by the ATR element (24), and which outputs a reference detection signal depending on the infrared radiation detected by the infrared reference sensor (34). According to the invention, the infrared radiation source (22) is designed and arranged to radiate an infrared measuring radiation portion (56) detected by the infrared measuring sensor (32) in a measuring radiation direction, and to simultaneously radiate an infrared reference radiation portion (60) detected by the infrared reference sensor (34) in a reference radiation direction that is different to the measuring radiation direction.
G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
23.
COMBINATION ELECTRODE COMPRISING A DIAPHRAGM HAVING A CROSS-LINKED HYDROGEL, AND METHOD FOR PRODUCING THE COMBINATION ELECTRODE
The invention relates to a combination electrode (1) for measuring a working fluid, having a working electrode (2), a reference electrode (3), a diaphragm (10), and a first electrically conductive fluid (6), which is in contact with the reference electrode (3) and the diaphragm (10) such that the diaphragm (10) is connected to the reference electrode (3) in an electrically conductive manner via the first electrically conductive fluid (6), the diaphragm (10) having a cross-linked hydrogel and is stabilised by at least one support element. The invention also relates to a method for producing the combination electrode (1).
A spectroscopic sensor assembly for detecting at least one predefined analyte constituent of a measurement fluid, the sensor assembly including a sensor housing; a radiation source; a detector device; a barrier assembly, which is transmissive for measurement radiation and is impermeable to the analyte constituent; a polymer matrix, which absorbs and releases the analyte constituent; a reflector assembly, which has a signal side facing the polymer matrix and facing the barrier assembly; the reflector assembly has a passage extending through the reflector assembly, through which passage the analyte constituent is exchanged between a measurement environment and the polymer matrix, which polymer matrix is located on the signal side of the reflector assembly; the reflector assembly reflects incident measurement radiation back toward the apparatus portion; the sensor assembly having a spacing means different from the polymer matrix that is designed to prevent the reflector assembly from approaching the barrier assembly.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/85 - Investigating moving fluids or granular solids
25.
METHOD FOR ASSIGNING A PIPETTE TIP TO A PIPETTE TIP CLASS ON THE BASIS OF THE PNEUMATIC BEHAVIOUR THEREOF
A method for assigning a pipette tip to a certain class of pipette tips from a plurality of different pipette tip classes, the method including the following steps: coupling the pipette tip to a gas displacement device such that a device-side volume formed in the gas displacement device and a tip-side volume formed by the pipette tip communicate with each other, and thereby forming a measuring volume including the communicating volumes of the device-side volume and the tip-side volume; operating the gas displacement device and thereby changing the gas pressure in the measuring volume; detecting the gas pressure in the measuring volume over a detection time period; determining at least one absolute value of at least one characteristic variable characterizing the detected gas pressure; comparing the at least one determined absolute value with at least one predetermined calibration value; and, depending on the comparison result, assigning the pipette tip to a pipette tip class and outputting an item of class assignment information representing the assigned pipette tip class.
The invention relates to a method for separating HMW DNA and/or UHMW DNA from a carrier element (8), to which the DNA is removeably attached, using a centrifugation container set (2) with at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and at least one collection vessel 40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) is removeably attached to the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) has a container wall (14) surrounding a container interior (12) and a container base (16) with at least one out-flow opening (20), wherein the out-flow opening (20) forms at least one flow path (24) for a fluid to be centrifugated from the container interior (12) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel interior (42) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and the at least one collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) are geometrically coordinated with one another in such a way that there is a clear distance (a) from an outlet opening (22) of the out-flow opening (20) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel base (44) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) in the direction of a main extension axis (H1) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h), wherein the clear distance (a) is selected in such a way that any strands of the DNA are separated from the outlet opening (22).
A pipetting device for outputting amounts of a dosing fluid of less than 1 μl including a fluid volume; a pipetting plunger that can be moved along a plunger path, wherein a displacement of the pipetting plunger brings about a first pressure change in the fluid volume; a movement drive which is force-transmittingly connected to the pipetting plunger in order to drive the pipetting plunger such that it moves along the plunger path; a sound source which is designed to generate at least one sound impulse as a second pressure change in the fluid volume; and a control device which is designed to control the movement drive and the sound source, the pipetting device having a pipetting channel which extends along a channel axis and in which both the pipetting plunger is moveably accommodated along the channel axis as the plunger path and the fluid volume is accommodated, wherein the fluid volume includes a working gas which wets a plunger surface of the pipetting plunger, wherein, in addition, the sound source is designed and arranged to generate the at least one sound impulse in the working gas.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
28.
PIPETTING UNIT WITH CAPACITIVE LIQUID DETECTION, COMBINATION OF SUCH A PIPETTING UNIT AND A PIPETTING TIP, AND METHOD FOR CAPACITIVELY DETECTING PIPETTING LIQUID
A pipetting unit (2) with capacitive liquid detection comprises: a pressure tube (10); a shield (12) disposed around the pressure tube (10); a coupling (14) for temporarily attaching a pipetting tip (4) to the pipetting unit (2), wherein when the pipetting tip (4) is connected, an electrical connection is established between the pressure tube (10) and the pipetting tip (4); and an electric circuit (20) coupled to the pressure tube (10) and the shield (12), wherein the electric circuit (20) is configured to apply a time-variable electrical signal to the pressure tube (10), said time-variable electrical signal permitting a capacitive detection of a contact between the pipetting tip (4) and a pipetting liquid (112) when the pipetting tip (4) is connected, and wherein the electric circuit (20) is configured to connect the shield (12) to ground.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01F 23/263 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields by measuring variations in capacitance of capacitors
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
29.
TURBIDITY SENSOR, IN PARTICULAR FOR DETERMINING A CELL DENSITY OF A SUSPENSION
The present invention relates to a turbidity sensor (10) for detecting clouding of a fluid by particulates contained in the fluid, wherein the turbidity sensor (10) comprises: - a fluid detection region (14) for the reception and metrological detection of fluid; - a radiation source (54) for emitting radiation into the fluid detection region (14); - a first radiation sensor (32) for detecting a first part of the radiation emitted by the radiation source (54); and - a second radiation sensor (62), different from the first radiation sensor (32), for detecting a second part of the radiation emitted by the radiation source (54) that is different from the first part, wherein at least a portion of the fluid detection region (14) is located between the first radiation sensor (32) and the second radiation sensor (62). According to the invention, the second radiation sensor (62) is located in the beam path (OA) of the first part of the radiation emitted by the radiation source (54) that is detected by the first radiation sensor (32).
The present application relates to a pipetting device and a pipetting method for pipetting, therefore for aspirating and/or dispensing, a metered liquid using a working gas, independently of the flow- and/or wetting characteristics of the metered liquid, wherein a pipetting channel comprises a first working region, of which the known base temperature is in a lower base temperature range, and a second working region, of which the known working temperature is in a working temperature range that is increased with respect to the base temperature range.
A sensor arrangement includes a reaction subassembly having a housing and a detector subassembly. The housing is a layered component arrangement encompassing a luminophore-containing reaction laminate excitable, by irradiation with a first electromagnetic radiation of a first wavelength, to emit a second electromagnetic radiation of a second wavelength different from the first wavelength; and a temperature-detection laminate emitting an infrared radiation. The housing includes an opening for introducing a fluid, a reaction window and a temperature-sensing window. The reaction window transmits the first and second electromagnetic radiation, and the temperature-sensing window is penetrable by infrared radiation. The detector subassembly encompasses a radiation source emitting the first electromagnetic radiation, a radiation detector detecting the second electromagnetic radiation, and an infrared detector detecting, through the temperature detection window, the infrared radiation emitted from the temperature detection laminate. The reaction laminate and the temperature-detection laminate are embodied separately.
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
32.
SENSOR ASSEMBLY FOR SPECTROSCOPICALLY DETECTING SUBSTANCES
The present invention relates to a spectroscopic sensor assembly (10) for detecting at least one predefined analyte constituent of a measurement fluid, the sensor assembly (10) comprising: - a sensor housing (12); - a radiation source (64); - a detector device (66); - a barrier assembly (28), which is transmissive for measurement radiation and is impermeable to the analyte constituent; - a polymer matrix (40), which absorbs and releases the analyte constituent; - a reflector assembly (36, 136), which has a signal side (36b; 136b) facing the polymer matrix (40) and facing the barrier assembly (28); wherein the reflector assembly (36; 136) has at least one passage (54; 154) extending through the reflector assembly, through which passage the analyte constituent is exchanged between a measurement environment (M) and the polymer matrix (40), which polymer matrix is located on the signal side (36b; 136b) of the reflector assembly (10); and wherein the reflector assembly (10) reflects incident measurement radiation back toward the apparatus portion (18). According to the invention, the sensor assembly (10) has a spacing means (48) different from the polymer matrix (40), the spacing means being designed to prevent the reflector assembly (36; 136) from approaching the barrier assembly (28).
G01N 21/85 - Investigating moving fluids or granular solids
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
33.
METHOD AND SENSOR FOR DETERMINING A VALUE INDICATING THE IMPEDANCE OF A SUSPENSION
A method for determining a value indicative of the impedance of a suspension in the framework of impedance spectroscopy comprises the following steps: generating an excitation current through the suspension, oscillating at an excitation frequency; determining a first impedance measurement value on the basis of the excitation current and a first voltage at a first pair of measurement electrodes; determining a second impedance measurement value on the basis of the excitation current and a second voltage at a second pair of measurement electrodes; determining the value indicative of the impedance of the suspension by correlating the first impedance measurement and the second impedance measurement.
A liquid-metering device for discharging metered liquid in the nanometer range, includes a pipetting-tip receiving device defining, at least in a metering-ready operating position of the liquid-metering device, a receiving space that runs along a virtual receiving axis and is designed to receive a portion of a pipetting-tip. The liquid-metering device also includes a triggering plunger moveable relative to the pipetting-tip receiving device, between a standby position and a triggering position. The liquid-metering device also includes movement drive, which is coupled to the triggering plunger so as to transmit motion, and a control device for controlling operation of the movement drive. A first and second deformation formation define therebetween an axial longitudinal region of the receiving space as a deformation region, in which region the first and second formations can be brought closer or farther away to/from one another. The triggering plunger is located in the deformation region.
The invention relates to a pipetting device (10) for outputting amounts of a dosing fluid (32) of less than 1 µl, comprising: a fluid volume (39); a pipetting plunger (14) that can be moved along a plunger path, wherein a displacement of the pipetting plunger (14) brings about a first pressure change in the fluid volume (39); a movement drive (22) which is force-transmittingly connected to the pipetting plunger (14) in order to drive the pipetting plunger (14) such that it moves along the plunger path; a sound source (42) which is designed to generate at least one sound impulse as a second pressure change in the fluid volume (39); and a control device (24) which is designed to control the movement drive (22) and the sound source (42). According to the invention, the pipetting device (10) comprises a pipetting channel (11) which extends along a channel axis (K) and in which both the pipetting plunger (14) is moveably accommodated along the channel axis (K) as the plunger path and the fluid volume (39) is accommodated, wherein the fluid volume (39) comprises a working gas (34) which wets a plunger surface (14a) of the pipetting plunger (14), wherein, in addition, the sound source (42) is designed and arranged to generate the at least one sound impulse in the working gas (34).
a valve subassembly (63) which comprises a valve body (64) and a valve seat (66) and which is provided between the upstream and the downstream respiratory gas conduit (54, 58) in such a way that, in the context of a predetermined first respiratory gas overpressure in the upstream respiratory gas conduit (54) relative to the downstream respiratory gas conduit (58), it permits an expiratory respiratory gas flow from the upstream respiratory gas conduit (54) into the downstream respiratory gas conduit (58); and in the context of a predetermined second respiratory gas overpressure in the downstream respiratory gas conduit (58) relative to the upstream respiratory gas conduit (54), it blocks a gas flow from the downstream respiratory gas conduit (58) into the upstream respiratory gas conduit (54).
Provision is made according to the present invention that the exhalation valve arrangement (22) comprises a bypass chamber (74) which communicates in terms of flow mechanics with the upstream respiratory gas conduit (54) and which extends, proceeding from the upstream respiratory gas conduit (54), into the region of the downstream respiratory gas conduit (58) and is embodied there for attachment of a gas pressure sensor (80).
A pipette device comprises a pipette channel filled with compressible working gas, a pipette piston movable along the pipette path, a piston drive, which drives the pipette piston, a control device, a data memory connected to the control device for signal transmission, a pressure sensor which detects the pressure of the working gas and which is connected to the control device, a position sensor which detects a position of the pipette piston and which is connected to the control device. The control device is designed to determine a quality of a dispensing sequence on the basis of a target residual quantity value, which represents the target residual quantity of dosing liquid remaining in the pipette channel, of a working gas pressure and of an end position of the pipette piston, in each case after the end of the dispensing sequence, and to output the determined quality.
A pH combination electrode includes inner and outer tubes, working and reference electrodes, and a hydrogel diaphragm between the tubes. A seal is disposed inside the inner tube closer to a first inner tube end than to the second inner tube end. An extended reference chamber is formed inside the inner tube between the seal and the second inner tube end. A first conductive fluid is contained in the inner tube between the seal and the first inner tube end. A second conductive fluid is contained in the extended reference chamber and in a reference chamber formed between the inner and outer tubes. A through-hole in the inner tube allows the second conductive fluid to flow between the reference chamber and the extended reference chamber. The working electrode extends into the inner tube, through the seal and into the first conductive fluid. The reference electrode contacts the second conductive fluid.
A combination electrode includes a working electrode, a reference electrode, a hydrogel diaphragm, an outer tube and an inner tube. The working electrode is disposed in the inner tube. The reference electrode is disposed in a reference chamber formed between the inner tube and the outer tube. The hydrogel diaphragm seals the opening between an end of the outer tube and the inner tube when the hydrogel swells upon coming in contact with a first electrically conductive fluid that is introduced into the reference chamber. The diaphragm is coupled to the reference electrode in an electrically conductive manner through the first electrically conductive fluid, which contacts both the reference electrode and the diaphragm. The inner tube is closed by a glass membrane that is coupled to the working electrode in an electrically conductive manner through a second electrically conductive fluid that contacts both the glass membrane and the working electrode.
The invention relates to a sensor holder (10) for a sensor assembly (82), wherein the sensor holder (10) has a tube section (12) with an outer thread (22) formed thereon, wherein, as a securing thread (22), the outer thread (22) has a securing/releasing formation (60a, 60, b, 60c) in at least one peripheral section of a thread groove (22a), wherein the securing/releasing formation (60a, 60, b, 60c), wherein the securing/releasing formation (60a, 60, b, 60c) reduces the cross-sectional area (Q) of the thread groove (22a) in relation to a peripheral section of the thread groove (22a) that is free of the securing/releasing formation (60a, 60, b, 60c), wherein a material weakening (48) is formed in a region of weakness (46) of the sensor holder (10), wherein the region of weakness (46) includes the entire outer thread (22) and extends beyond the outer thread (22) by at least double the thread pitch of the outer thread (22) and axially in relation to a screw axis (S) of the outer thread (22) on both sides of the outer thread (22), wherein a direction of the material weakening (48), in which the material weakening (48) has its largest measurement, has an axial component (48a) and/or a component (48b) in the peripheral direction in relation to the screw axis (S) of the outer thread (22), wherein the at least one securing/releasing formation (60a, 60, b, 60c) is arranged in the axial extension region of the material weakening (48) and/or is arranged in the peripheral extension region of the material weakening (48).
The present invention relates to a method for assigning a pipette tip (26) to a certain class of pipette tips (26) from a plurality of different pipette tip classes, the method comprising the following steps: coupling the pipette tip (26) to a gas displacement device (12/14) such that a device-side volume (11a, 11b) formed in the gas displacement device (12, 14) and a tip-side volume (11c) formed by the pipette tip (26) communicate with each other, and thereby forming a measuring volume (40) comprising the communicating volumes of the device-side volume (11a, 11b) and the tip-side volume (11c); operating the gas displacement device (12, 14) and thereby changing the gas pressure in the measuring volume (40); detecting the gas pressure in the measuring volume (40) over a detection time period; determining at least one absolute value of at least one characteristic variable characterising the detected gas pressure; comparing the at least one determined absolute value with at least one predetermined calibration value; and, depending on the comparison result, assigning the pipette tip (26) to a pipette tip class and outputting an item of class assignment information representing the assigned pipette tip class.
A method is provided for degradation-compensated evaluation of detection signals of a sensor arrangement operating on the principle of luminescence quenching, which arrangement has a luminophore that degrades over time, an excitation radiation source, and at least one optical sensor. The luminophore radiates, in accordance with a response characteristic of the sensor arrangement, in reaction to irradiation with a predefined modulated excitation radiation and as a function of the extent of an interaction of the luminophore with a quencher substance that quenches the luminescence of the luminophore. A response radiation is detected by the at least one optical sensor. The sensor arrangement outputs a detected intensity value representing an intensity of the response radiation and a detected phase value representing a phase difference of the response radiation with respect to the modulation of the excitation radiation. A predetermined calibration value correlation is identified in consideration of the reference response characteristic.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/85 - Investigating moving fluids or granular solids
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
43.
DEVICE AND METHOD FOR REVERSIBLY IMMOBILISING BIOMOLECULES
A device for the reversible immobilization of biomolecules includes a container which can be filled with a liquid containing biomolecules and has an opening and a valve. The valve can be opened and closed by a closing mechanism for the controllable drainage of the liquid. Magnetic particles, to which the biomolecules can be immobilized can be arranged freely movable in the container. A magnet for fixing the magnetic particles in the container is arranged at the container, and the liquid can be removed from the container through the opening in the open state of the valve.
According to the invention, a laboratory system (100) for the automated measurement of the transmission of samples (17) comprises a support housing, a sample container (7) for receiving the samples (17) and a transport device (120) for transporting the sample container (7) in the support housing. The invention is characterised in that the laboratory system (100) further has a measuring device (9) for examining at least one sample (17) in the sample container (7) using an illumination device (20) and a detection device (30), the transport device (120) being configured to transport the measuring device (9) and the measuring device (9) being designed in two pieces such that the illumination device (20) and the detection device (30) can be separated and assembled by means of the transport device.
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
45.
PIPETTING UNIT WITH CAPACITIVE LIQUID DETECTION FUNCTION, COMBINATION OF SUCH A PIPETTING UNIT AND A PIPETTE TIP, AND METHOD FOR CAPACITIVELY DETECTING PIPETTING LIQUID
The invention relates to a pipetting unit (2) with a capacitive liquid detection function, comprising: a pressure tube (10); a shield (12) which is arranged about the pressure tube (10); a coupling (14) for temporarily securing a pipette tip (4) to the pipetting unit (2), wherein an electric connection is established between the pressure tube (10) and the pipette tip (4) when the pipette tip (4) is connected; and an electric circuit (20) which is coupled to the pressure tube (10) and the shield (12), wherein the electric circuit (20) is designed to apply an electric signal which can change over time to the pressure tube (10), said signal allowing a capacitive detection of a contact between the pipette tip (4) and the pipetting liquid (112) when the pipette tip (4) is connected, and the electric circuit (20) is designed to connect the shield (12) to ground.
G01F 23/26 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
46.
Pipetting device for pulsed pipetting with a pipetting piston movement controlled on the basis of a detection of the piston position
A pipetting device includes a pipetting channel at least partially filled with working gas, a pipetting tip accessible through a pipetting opening such that the volume of dosing liquid drawn into the receiving chamber can be varied by changing the pressure of the working gas in the receiving chamber, a pipetting piston for changing the pressure of the working gas and accommodated in the pipetting channel to be movable along the pipetting channel, a drive driving the pipetting piston to perform a movement along the pipetting channel, a control device controlling the drive, and a pressure sensor sensing the pressure of the working gas. The control device controls the drive to generate a pressure pulse in the pipetting channel based on the pressure signal output by the pressure sensor whereby the pressure of the working gas during the pulse follows a predefined working gas target pressure pulse curve.
A device for monitoring a biological process in a liquid medium includes a wall portion, a silanization layer and a sensor arrangement. The device attaches to a container of a bioreactor and can be used with disposable bioreactors. The wall portion is adapted to retain the liquid medium during operation of the bioreactor. A through-hole is disposed in the wall portion. A silanization layer covers the surface encircling the through-hole and the wall portion between the liquid medium and the wall portion. The sensor arrangement includes a glass layer, a substrate and an electrode. The glass layer is bonded by an adhesive to the silanization layer so as to cover the through-hole. The electrode is mounted on the substrate and measures electrical conductivity through the liquid medium. The sensor arrangement also includes an optical sensor that detects electromagnetic radiation that passes from the liquid medium through the glass layer.
The present application relates to a pipetting device (10) and a pipetting method for pipetting, therefore for aspirating and/or dispensing, a metered liquid (32) using a working gas, independently of the flow- and/or wetting characteristics of the metered liquid (32), wherein a pipetting channel (12) comprises a first working region (AB1), of which the known base temperature (T∞) is in a lower base temperature range, and a second working region (AB2), of which the known working temperature (TAB2) is in a working temperature range that is increased with respect to the base temperature range.
G01N 11/08 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture by measuring pressure required to produce a known flow
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
49.
Pipetting device with a stator magnet assembly, which can be used on both sides, as part of a linear-motor drive of a pipetting unit
A pipetting device includes pipetting unit(s), a guide assembly with at least one guide rail on which the pipetting unit(s) is guided in order to be moved along a movement axis, and a linear drive assembly, by which the pipetting unit(s) can be driven in order to be moved along the movement axis. The linear drive device has a stationary stator, and the at least one pipetting unit forms a linear drive assembly rotor which can be moved along the movement axis relative to the stator. The pipetting device also has at least two rotor magnet assemblies which interact with the same common stator magnet assembly so as to generate a drive force and which are arranged at a distance from one another along a spacing axis that is orthogonal to the movement axis. The common stator magnet assembly is located between the at least two rotor magnet assemblies.
The invention relates to an impedance spectroscopy sensor (10), comprising: a carrier plate (12) having a media side (14) facing a medium during the measuring operation and having a connection side (16) opposite the media side (14) for electrically conductively connecting a control and/or evaluation electronics system (39); through-openings (72-82) which run between the media side (14) and the connection side (14), penetrating the carrier plate (12); a plurality of electrically conductive sensor surfaces (46-56) on the media side (14), which are at least partially exposed; and a plurality of electrical contact surfaces (22-36, 40, 42) on the connection side (16), which are at least partially exposed on the connection side (16); wherein at least one portion of the electrical contact surfaces (22-36, 40, 42) are electrically conductively connected to the sensor surfaces (46-56) on the media side (14) via the through-openings (72-82). According to the invention, a media cover layer (70) is applied at least to the media side (14), which has recesses (58-68) in the extension region of the sensor surfaces (46-56) penetrating the media cover layer (70) in the thickness direction, and which covers at least one portion of the through-openings (72-82) and a respective conductor path section coming from a through-opening (72-82).
G01N 27/02 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
G01N 27/07 - Construction of measuring vesselsElectrodes therefor
G01N 27/22 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
45 - Legal and security services; personal services for individuals.
Goods & Services
Apparatus, instruments and cables for electricity; Measuring, detecting and monitoring instruments, indicators and controllers; Scientific research and laboratory apparatus, educational apparatus and simulators; Electrodes; Cathodes; Sensors, detectors and monitoring instruments; Scientific apparatus and instruments; Inspecting apparatus and instruments; Measuring devices; Analysis and diagnostic apparatus, not for medical purposes; Diaphragms for scientific apparatus; Apparatus for recording, transmitting or reproduction of sounds, images or data; Data carriers for recording images, sound and data; Recorded content; Information technology and audiovisual equipment; Electric control apparatus; Software; Computers; Data processing equipment; Computer peripheral devices; Parts and accessories for all the aforesaid goods, included in this class. Medical and veterinary apparatus and instruments; Membranes for filtration [medical]; Electrodes for use with medical apparatus; Electrodes for medical use; Measuring devices for medical use; Measuring instruments adapted for medical use; Electrodes for picking up biological parameters; Non-selective electrodes being chemically sensitive probes [for medical use]; Diagnostic, examination, and monitoring equipment; Medical analytical apparatus for medical purposes; Parts and accessories for all the aforesaid goods, included in this class. Licensing authority services; Issuing of licences for computer software; Licensing of technology.
52.
Method and sensor for determining the permittivity of a cell population
A method for determining a value indicative of the permittivity of a cell population in the context of impedance spectroscopy comprises the following steps: generating an excitation current through the cell population, which oscillates with an excitation frequency; measuring a voltage in the cell population between a first measuring electrode (12) and a second measuring electrode (14); sampling the excitation current, wherein first sampled values for the excitation current are generated; sampling the voltage between the first measuring electrode (12) and the second measuring electrode (14), wherein second sampled values for the voltage between the first measuring electrode and the second measuring electrode are generated; and determining the value indicative of the permittivity of the cell population on the basis of the first sampled values and the second sampled values.
The present invention relates to a pipette device with a pipette channel which extends along a channel axis defining an axial direction and which passes through a channel component arrangement which, at a coupling longitudinal end, has a coupling configuration for the releasable coupling of a pipette tip. The coupling configuration has a locking component with a radially outwardly facing engagement surface arrangement, which is movable between a locking position more radially remote from the channel axis and an unlocking position lying radially closer to the channel axis. The coupling configuration has a sealing component separate from the locking component, and that the actuator drive has a switchable magnetic field source and a reaction component which is movable by the locally changing magnetic field thereof and which is connected to the locking actuator in such a way as to transmit movement.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
54.
Integrated motor cassette for connection to and for use in a pipetting system, pipetting system, and method for exchanging an integrated motor cassette of a pipetting system
An integrated motor cartridge (2) for connection to and for use in a pipetting system comprises a housing (4); a guide tube (14); a piston (16) provided with a plurality of permanent magnets (18), the piston having a pressure tube facing side and a pressure tube distal side, the piston being arranged in the guide tube and the piston having at least one seal (24) with respect to the guide tube; and a coil assembly (20) by means of which the piston can be moved in the guide tube when power is supplied to the coil assembly; wherein the guide tube, the piston and the coil assembly are arranged in the housing. The integrated motor cartridge further comprises a pressure tube connection (6) by means of which the guide tube, on the pressure tube facing side of the piston, can be connected to a pressure tube of the pipetting system in a gastight manner; and a power connection (8) which is coupled to the coil assembly and adapted to be coupled to a power supply arranged outside of the integrated motor cartridge; wherein the integrated motor cartridge can be introduced into and removed from the pipetting system as a unit.
A pipetting apparatus (10) having a guidance frame (12) having a first linear guidance rail (52) and having a second linear guidance rail (56), the first and the second linear guidance rail (52, 56) proceeding parallel to one another along a displacement axis (VL) and being provided at a distance from one another orthogonally to the displacement axis (VL), and having a pipetting channel (14) which extends along a channel axis (K14) that is nonparallel, preferably orthogonal, to the displacement axis (VL) and which is guided displaceably along the displacement axis (VL) with a first bearing component (54) on the first linear guidance rail (52) and with a second bearing component (58) on the second linear guidance rail (56), is characterized in that the first and the second bearing component (54, 58) are arranged with a spacing (A) from one another along the displacement axis (VL).
A pipetting device (10) comprising - a workspace (14) over a work surface (18) which is configured for the provision of laboratory material (20), - at least one pipetting channel (36) which is movable relative to the work surface (18), wherein the pipetting channel (36) is both movable parallel to the work surface (18) and also capable of being moved closer to and away from the work surface (18), wherein the pipetting channel (36) is designed to dispense dosing liquid into, and/or receive dosing liquid from, at least one vessel (26, 28) encompassed by the laboratory material (20) in the workspace (14), - a sensor device (42) which is designed to detect at least one physical variable · of a section of the pipetting device (10) and/or · of laboratory material (20) provided in the workspace (14) and/or · of a dosing liquid and/or · of a gas surrounding the pipetting device (10), and - an electronic data processing device (70) which is configured for processing operating data and/or state data of the pipetting device (10). According to the invention, it is provided that the sensor device (42) has a transmitter (62) which is designed to transmit signals from the sensor device (42) wirelessly to the electronic data processing device (70), and that the electronic data processing device (70) has a receiver (64) which is designed to wirelessly receive signals from the sensor device (42).
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
The invention relates to a combination pH electrode (1) having: an inner tube (5) which has a first inner tube longitudinal end (19), which is closed, and a second inner tube longitudinal end (20); a first seal (12), which is situated in the inner tube and seals off the first inner tube longitudinal end; a first electrically conductive fluid (6), which is situated in the inner tube between the first inner tube longitudinal end and the first seal; an outer tube (4), which is situated around the inner tube and delimits a reference chamber (21) situated between the outer tube and the inner tube; a through-hole (10), which is situated in the inner tube between the first seal and the second inner tube longitudinal end and fluidically connects the reference chamber to an extended reference chamber (22), which is situated inside the inner tube in a region between the first seal and the second inner tube longitudinal end; a second electrically conductive fluid (7), which is situated in the reference chamber and the extended reference chamber; a working electrode (2), which extends into the first conductive fluid via the first seal; and a reference electrode (3), which is in contact with the second conductive fluid. The outer tube (4) has a first outer tube longitudinal end (23) in the region of the first inner tube longitudinal end (19), and the combination pH electrode (1) has a diaphragm (14), preferably a hydrogel, in the region of the first outer tube longitudinal end (23), said diaphragm being designed to keep the second electrically conductive fluid (7) in the reference chamber (21). The inner tube (5) has a glass membrane (9) in the region of the first inner tube longitudinal end (19).
The invention relates to a combination electrode (1), preferably a pH glass electrode, for measuring a fluid to be measured, having a working electrode (2), a reference electrode (3), a diaphragm (10), preferably containing a thermoplastic polyurethane block copolymer, and a first electrically conductive fluid (6), which is in contact with the reference electrode (3) and the diaphragm (10) such that the diaphragm (10) is connected to the reference electrode (2) in an electrically conductive manner via the first electrically conductive fluid (6), the diaphragm (10) having a hydrogel. The invention further relates to a method for producing the combination electrode (1).
The invention relates to a liquid-metering device (10) for ballistically discharging a discrete metered amount of metered liquid in a metering volume range of 0.3 nl to 900 nl from a metered-liquid reservoir, said device comprising: - a pipetting-tip receiving device (14), which defines, at least in a metering-ready operating position of the liquid-metering device (10), a receiving space (40) that runs along a virtual receiving axis (A) and is designed to receive a portion of a pipetting tip (42); - a triggering plunger (26), which is movable relative to the pipetting-tip receiving device (14) and can be moved between a standby position in which it is further retracted from the receiving space (40) and a triggering position in which it protrudes further into the receiving space (40); - a movement drive (30), which is coupled to the triggering plunger (26) so as to transmit motion; and - a control device (28) for controlling the operation of the movement drive (30). According to the invention, the liquid-metering device (10) has a first deformation formation (46) and a second deformation formation (48), the first deformation formation (46) and the second deformation formation (48) defining therebetween an axial longitudinal region of the receiving space (40) as a deformation region (44), in which region the first deformation formation (46) and the second deformation formation (48) can be brought closer to one another and moved away from one another, the triggering plunger (26) being located in the deformation region (44) of the receiving space (40) when the triggering plunger is in the triggering position.
The invention relates to a method for determining the volume of a liquid (5), said method comprising the steps: a) providing a liquid receiving layer, which has a surface (4), b) dispensing a desired volume of the liquid (5) from a dispensing device onto the surface (4) of the liquid receiving layer, wherein a spot (6) is created on the surface (4) of the liquid receiving layer as a result of the liquid (5) being adsorbed by the liquid receiving layer, and the spot (6) has different optical properties as compared to regions of the liquid receiving layer that are free of the liquid (5), c) recording an image of the spot (6), d) determining the surface area of the spot (6), and e) drawing a conclusion, based on the surface area of the spot (6), about the actual volume of the liquid (5) dispensed in step b). The invention furthermore relates to a pipetting robot designed to carry out the method.
The invention relates to a method for determining a value indicating the impedance of a suspension, as part of impedance spectroscopy, comprising the following steps: generating an excitation current oscillating at an excitation frequency through the suspension; determining a first impedance measurement value on the basis of the excitation current and a first voltage on a first pair of measurement electrodes; determining a second impedance measurement value on the basis of the excitation current and a second voltage on a second pair of measurement electrodes; determining the value indicating the impedance of the suspension by correlating the first impedance measurement value and the second impedance measurement value.
A magnetic isolating apparatus (10) for isolating magnetic particles (66) from a suspension has an immersion section (30) which is designed to be temporarily immersed in the suspension, a guide apparatus (16) which extends along a guide path (F), a magnet arrangement (18) which is guided by the guide apparatus (16) such that it can be moved between an active position which is situated close to the immersion section (30) and an inactive position which is positioned further away from the immersion section (30) along the guide path (F), so that a magnetic field in the region of the immersion section (30) can be changed by moving the magnet arrangement (18) between the active position and the inactive position, and a drive apparatus (22, 50) by which the magnet arrangement (18) can be driven to move at least in a direction between the active position and the inactive position, wherein the drive apparatus (22, 50) is coupled in a non-physical manner to the magnet arrangement (18) by a force field and/or a fluid so as to transmit drive force.
A pipette device (10) comprises a pipette channel (11) which extends along a channel path (K) and which is filled with compressible working gas (34), a pipette piston (14) movable along the pipette path (K), a piston drive (20), which drives the pipette piston (14) in a movement along the channel path (K), a control device (24), a data memory (25) connected to the control device (24) for signal transmission, a pressure sensor (38) which detects the pressure of the working gas (34) and which is connected to the control device (24), a position sensor (17) which detects a position of the pipette piston (14) and which is connected to the control device (24), wherein the control device (24) is designed to drive the pipette piston (14) in a pulsed dispensing movement for individual volume dispensing an individual volume (36) of not more than 1 µl, wherein an overpressure pulse with a duration of not more than 50 ms is generated in the working gas (34) by the two oppositely directed movement portions of the dispensing movement for individual volume dispensing. According to the invention, the control device (24) is designed to determine a quality of a dispensing sequence on the basis of a target residual quantity value, which represents the target residual quantity of dosing liquid (33) remaining in the pipette channel (11), of a working gas pressure and of an end position (P2) of the pipette piston (14), in each case after the end of the dispensing sequence, and to output the determined quality.
Method for contactlessly determining the position of a driven rotor of an electric motor, electric motor, and pipetting system for aspirating and dispensing pipetting liquid having such an electric motor
There is provided a method for contactless determination of the position of a driven moving portion (4) of an electric motor (2) by means of a plurality of magnetic field sensors (8), wherein the moving portion is movably arranged with respect to a stator (6) and has a plurality of permanent magnets (40) which generate a moving-portion magnetic field having a plurality of periodically spaced apart maxima, and wherein the plurality of magnetic field sensors are arranged along a movement path (43) of the moving portion. The method comprises the following steps: by means of the plurality of magnetic field sensors, determining a plurality of measured values (70) for a momentary magnetic field that is generated by the plurality of permanent magnets and dependent on the position of the moving portion, determining a specific spectral signal component (74) from the plurality of measured values (70), the specific spectral signal component having the spatial frequency corresponding to the distance between adjacent like maxima of the moving-portion magnetic field, and determining the position of the driven moving portion by means of the specific spectral signal component.
G01D 5/14 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage
G01R 33/00 - Arrangements or instruments for measuring magnetic variables
b), the infrared radiation (I) emitted from the temperature-detection laminate (64).
Provision is made according to the present invention that the reaction laminate (62) and the temperature-detection laminate (64) are embodied separately from one another.
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
66.
Fluid supply interface having a safety valve for a cell culture system, use of such a fluid supply interface for managing cell culture containers, and cell culture management system
A fluid supply interface includes at least one supply coupling configuration, at least one discharge coupling configuration, at least one user coupling configuration, and a fluid conduit that connects the supply, discharge, and user coupling configurations to one another. A supply valve is capable of having fluid flow through it or is blocked for flow through it. A discharge valve is capable of having fluid flow through it or is blocked for flow through it. The supply valve is preloaded into a blocking position that prevents flow, and opens by means of a sufficiently large pressure difference between the two sides of the supply valve, against the preload force, for flow through in a direction from the supply coupling configuration toward the fluid conduit. The discharge valve likewise being preloaded into a closed position that prevents flow through it.
The invention relates to a device (1) for monitoring a biological process in a liquid medium, comprising a wall section (2) which is designed to hold the medium during the operation of the device (1), a silanizing layer (3), an adhesive (7), and a sensor assembly (12). The wall section (2) has a passage hole (10), the silanizing layer (3) is applied directly onto the wall section (2) and completely around the passage hole (10), the sensor assembly (12) has a support which has a glass layer (6), and the adhesive (7) sealingly adheres the silanizing layer (3) to the glass layer (6). The invention additionally relates to a bioreactor comprising the device (1) and a container and to a method for producing the device (1).
The invention relates to pipetting device (10) for the pulsed pipetting of dosing liquids in small dose volumes of less than 2 μΙ, the pipetting device (10) comprising: - a pipetting channel (11) at least partially filled with working gas (34); - a pipetting tip (26) which is accessible through a pipetting opening (30) such that the volume of dosing liquid drawn into the receiving chamber through the pipetting opening (30) can be varied by changing the pressure of the working gas in the receiving chamber; - a pipetting piston (14) for changing the pressure of the working gas (34) and accommodated in the pipetting channel so as to be movable along the pipetting channel (11); a drive (20) for driving the pipetting piston (14) to perform a movement along the pipetting channel (11); - a control device (24) for controlling the drive (20); and - a pressure sensor (38) for sensing the pressure of the working gas, the control device (24) being configured to control the drive (20) in order to generate a pressure pulse in the pipetting channel (11) with a maximum pulse duration of 40 ms on the basis of the pressure signal output by the pressure sensor (38) in such a way that the pressure of the working gas (34) during the pulse follows a predefined working gas target pressure pulse curve.
A pipetting apparatus and method for pulsed dispensing of small metered-liquid doses of no more than 1 μl. The apparatus includes a pipetting conduit at least partly filled with working gas, a pressure-modifying apparatus for modifying the pressure of the working gas, and a control apparatus for applying control to the pressure-modifying apparatus. The control apparatus can control the pressure-modifying apparatus so as to generate in the pipetting conduit, with respect to a reference holding pressure in the pipetting conduit which is necessary for immovable holding of the metered-liquid quantity, an overpressure pulse having a pulse duration of no more than 40 ms.
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
70.
METHOD FOR DEGRADATION-COMPENSATED EVALUATION OF LUMINESCENCE SENSOR DETECTION SIGNALS, AND EVALUATION APPARATUS THEREFOR
A method for a degradation-compensated evaluation of detection signals of a sensor arrangement (10) operating according to the principle of luminescence quenching, said sensor arrangement comprising a luminophore (33), an excitation radiation source (46) and an optical sensor (50), wherein, as a reaction to irradiation by a modulated excitation radiation (E1), the luminophore emits a response radiation (E2) depending on the extent of an interaction of the luminophore with a luminescence-quenching quencher substance (Q) and according to a sensor arrangement-typical response characteristic (62, 64, 66, 70, 72, 74), said response radiation being detected by the sensor, wherein the sensor arrangement outputs a detected intensity value and a detected phase value as detection signals, wherein, for an implemented detection of a response radiation, a deviation in terms of magnitude of one of the detected values of detected intensity value and detected phase value is reduced in terms of magnitude according to the stipulation of both the detected intensity value and the detected phase value, said deviation being based on a degradation-based change in the response characteristic at the time of the implemented detection in respect of a reference response characteristic, which is based on a calibration of the sensor arrangement, and hence a degradation-compensated detected value is ascertained, wherein a result value of the implemented detection related to the quencher substance is determined according to the stipulation of a predetermined calibration value relationship, ascertained taking into account the reference response characteristic, on the basis of the degradation-compensated detected value.
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/85 - Investigating moving fluids or granular solids
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
71.
Permanent-magnet piston assembly comprising an exoskeleton which holds permanent-magnet arrangements for a pipetting apparatus
Described is an oxygen permeable layer for detection of molecular oxygen, wherein the layer has a carrier material in which at least one particle is comprised, wherein the carrier material is polyvinylidene fluoride or a copolymer of polyvinylidene fluoride, and the particle comprises a polymer or a copolymer, wherein the polymer or copolymer of the particle has a chemically covalently bonded indicator compound for detection of molecular oxygen. In addition, a multilayer system for detection of molecular oxygen is described. Also described are a method for producing the layer, and the use of the layer or of the multilayer system for detection of molecular oxygen.
G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators
C08L 27/16 - Homopolymers or copolymers of vinylidene fluoride
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
A method for determining a value indicating the permittivity of a cell population through impedance spectroscopy has the following steps: generating an excitation current oscillating with an excitation frequency through the cell population; measuring a voltage in the cell population between a first measuring electrode (12) and a second measuring electrode (14); scanning the excitation current, wherein first scan values for the excitation current are generated; scanning the voltage between the first measuring electrode (12) and the second measuring electrode (14), wherein second scan values for the voltage between the first measuring electrode and the second measuring electrode are generated; and determining the value indicating the permittivity of the cell population based on the first scan values and the second scan values.
The invention relates to a pipetting device (10) comprising: - at least one pipetting unit (24, 26, 28, 30), - a guide assembly (23) with at least one guide rail (16, 18, 20, 22), on which the at least one pipetting unit (24, 26, 28, 30) is guided in order to be moved along a movement axis (B), and - a linear drive assembly (59), by means of which the at least one pipetting unit (24, 26, 28, 30) can be driven in order to be moved along the movement axis (B), wherein the linear drive device (59) has a stationary stator (42, 44), and the at least one pipetting unit (24, 26, 28, 30) forms a linear drive assembly (59) rotor which can be moved along the movement axis (B) relative to the stator (42, 44). The stator (42, 44) has a stator magnet assembly (45, 46), and the stator magnet assembly (45, 46) comprises a plurality of magnets (48) which are arranged one after the other along the movement axis (B) with alternating polarization directions (P). The rotor has at least one electromagnetic rotor magnet assembly (58, 60) which lies opposite the stator magnet assembly (45) along a gap axis (G) that is orthogonal to the movement direction (B). According to the invention, the pipetting device (10) has at least two rotor magnet assemblies (58, 60) which interact with the same common stator magnet assembly (45) so as to generate a drive force and which are arranged at a distance from one another along a spacing axis (A) that is orthogonal to the movement axis (B), said common stator magnet assembly (45) being located between the at least two rotor magnet assemblies (58, 60).
The present invention relates to a pipette device with a pipette channel (18) which extends along a channel axis (K) defining an axial direction and which passes through a channel component arrangement (20) which, at a coupling longitudinal end (30), has a coupling configuration (22) for the releasable coupling of a pipette tip (24), wherein the coupling configuration (22) has a locking component (44) with a radially outwardly facing engagement surface arrangement (48), which is movable between a locking position more radially remote from the channel axis (K) and an unlocking position lying radially closer to the channel axis (K), wherein the pipette device moreover has a locking actuator (60) which is adjustable between an engagement position, in which the locking actuator (60) prevents a movement of the engagement surface arrangement (48) from the locking position to the unlocking position, and a release position, in which the locking actuator (60) permits adoption of the unlocking position by the engagement surface arrangement (48), wherein the pipette device moreover has an actuator drive (66) which drives the locking actuator (60) at least in a direction of movement for adjustment between engagement position and release position. According to the invention, provision is made that the coupling configuration (22) has a sealing component (34) separate from the locking component (44), and that the actuator drive (66) has a switchable magnetic field source (68) and a reaction component (72) which is movable by the locally changing magnetic field thereof and which is connected to the locking actuator (60) in such a way as to transmit movement.
The invention relates to a device (1) for determining the volume of a liquid, said device comprising a plate (3) provided with at least one measuring system (5). Each measuring system (5) comprises a liquid store (7) and a plurality of measuring channels (9) that each have an inlet (13) and an end (15), and the measuring channels (9) of each measuring system (5) extend with the inlet (13) thereof from the corresponding liquid store (7).
A method is provided for calibrating impedance-spectroscopic biomass sensors that are embodied to detect information regarding the quantity and/or size of living cells in a biomass by means of an electric field having a periodically changing field direction
A calibration suspension encompasses an electrically conductive viscously flowable or viscoelastic carrier substance and electrically conductive solid particles and/or solid semiconductor particles received therein.
An electric field is generated having a periodically changing field direction, which acts on the calibration suspension.
At least one permittivity value is detected, respectively representing a permittivity of the calibration suspension, in a context of at least two electric fields having different field direction change frequencies.
A difference value is ascertained that represents a difference between the detected permittivity values.
The difference value is compared with a reference value associated with the calibration suspension.
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V. (Germany)
Inventor
Kissling, Tom
Grosch, Jens
Zumstein, Thomas
Traube, Andrea
Etzold, Carsten
Seiler, Tobias
Abstract
A cell separation apparatus a container for reception of a cell suspension and a conduit connected to the container for the conveyance of cell suspension out of the container. The conduit extends along a notional conduit path passing centrally through the conduit, the conduit path defining in the conduit an axial direction proceeding along the conduit path, a radial direction orthogonal to the conduit path, and a circumferential direction proceeding around the conduit path. A segment of the conduit constitutes a turbulent flow segment including a flow configuration. The flow configuration includes at least two axial configuration segments located axially behind one another to accelerate a cell suspension.
C12M 1/00 - Apparatus for enzymology or microbiology
79.
INTEGRATED MOTOR CASSETTE FOR CONNECTION TO AND FOR USE IN A PIPETTING SYSTEM, PIPETTING SYSTEM, AND METHOD FOR EXCHANGING AN INTEGRATED MOTOR CASSETTE OF A PIPETTING SYSTEM
The invention relates to an integrated motor cassette (2) for connection to and for use in a pipetting system comprises: a housing (4); a guide tube (14); a piston (16) provided with a plurality of permanent magnets (18), the piston having a pressure-tube-facing side and a pressure-tube-opposite side, the piston being arranged in the guide tube and the piston having at least one seal (24) with respect to the guide tube; and a coil assembly (20), by means of which the piston can be moved in the guide tube when power is supplied to the coil assembly. The guide tube, the piston and the coil assembly are arranged in the housing. The integrated motor cassette also comprises a pressure-tube connection (6), by means of which the guide tube, on the pressure-tube-facing side of the piston, can be connected gas-tight to a pressure tube of the pipetting system, and a power connection (8), which is coupled to the coil assembly and can be coupled to a power supply arranged outside of the integrated motor cassette. The integrated motor cassette can be inserted into and removed from the pipetting system as a unit.
A laboratory container, in particular a cell culture container, includes a container volume which is surrounded by a container body and which can be accessed from the outside through a container opening of the container body. The container has a fluid line which communicates with the container volume and which comprises a valve arrangement. The fluid line is designed to conduct fluid in order to discharge and/or introduce fluid out of and/or into the container volume. The fluid line can be selectively released in order to conduct a fluid or blocked by the valve arrangement, and the container additionally has a gas balancing opening, through which gas can be introduced into or discharged out of the container volume in counterflow to a possible fluid flow in the fluid line. The gas compensating opening is surrounded by a channel wall, said line channel running from the gas balancing opening into the container volume and opening into said container volume.
The invention relates to a liquid supply interface for a cell culture system for supplying cell cultures found in different cell culture containers with a nutrient medium, wherein the liquid supply interface comprises: a housing defining a flow area; a first connection formation for the liquid-transferring connection of a first fluid line to the housing; a second connection formation formed separately from the first for the liquid-transferring connection of a second fluid line to the housing; a third connection formation formed separately from the first two for the liquid-transferring connection of the housing to a third fluid line; a coupling formation formed separately from the connection formations, which is formed for the producible and detachable liquid-transferring coupling contact according to the operation, with a corresponding counter-coupling formation of a cell culture container.
The invention relates to a liquid supply interface for a cell culture system for supplying cell cultures found in different cell culture containers with a nutrient medium, wherein the liquid supply interface comprises: a housing defining a flow area; a first connection formation for the liquid-transferring connection of a first fluid line to the housing; a second connection formation formed separately from the first for the liquid-transferring connection of a second fluid line to the housing; a third connection formation formed separately from the first two for the liquid-transferring connection of the housing to a third fluid line; a coupling formation formed separately from the connection formations, which is formed for the producible and detachable liquid-transferring coupling contact according to the operation, with a corresponding counter-coupling formation of a cell culture container.
F16K 31/02 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic
C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
83.
METHOD FOR CONTACTLESSLY DETERMINING THE POSITION OF A DRIVEN ROTOR OF AN ELECTRIC MOTOR, ELECTRIC MOTOR, AND PIPETTING SYSTEM FOR ASPIRATING AND DISPENSING PIPETTING LIQUID HAVING SUCH AN ELECTRIC MOTOR
A method for contactlessly determining the position of a driven rotor (4) of an electric motor (2) by means of a plurality of magnetic field sensors (8) is provided, wherein the rotor is movably arranged with respect to a stator (6) and has a plurality of permanent magnets (40) which generate a rotor magnetic field having a plurality of maxima which are periodically spaced apart, and wherein the plurality of magnetic field sensors are arranged along a movement path (43) of the rotor. The method has the following steps of: by means of the plurality of magnetic field sensors, determining a plurality of measured values (70) for an instantaneous magnetic field which is dependent on the position of the rotor and is generated by the plurality of permanent magnets; determining a specific spectral signal component (74) from the plurality of measured values, wherein the specific spectral signal component has that spatial frequency which corresponds to the distance between adjacent identical maxima of the rotor magnetic field; and determining the position of the driven rotor by means of the specific spectral signal component.
F16K 31/08 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a magnet using a permanent magnet
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
F16K 31/06 - Operating meansReleasing devices electricOperating meansReleasing devices magnetic using a magnet
H02K 41/03 - Synchronous motorsMotors moving step by stepReluctance motors
H02K 11/215 - Magnetic effect devices, e.g. Hall-effect or magneto-resistive elements
G01D 5/20 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using electric or magnetic means influencing the magnitude of a current or voltage by varying inductance, e.g. by a movable armature
A description is given of a method for producing a portion unit from a gel-like carrier material with at least one biological cell, which is embedded in the carrier material, or at least one cell organelle, which is embedded in the carrier material. Also described is a portion unit that can be obtained by the method. Furthermore, various uses of the portion unit are described.
The invention relates to a sensor assembly (50) comprising a reaction module (72) with a housing (52) and with a detector module (54), wherein a layered component assembly (60) is provided in the housing (52) and comprises: - a luminophore-containing reaction layer body (62), which can be excited by irradiation with a first electromagnetic radiation of a first wavelength so as to emit a second electromagnetic radiation of a second wavelength different from the first wavelength, and - an infrared-radiation-emitting temperature detection layer body (64), the housing (52) comprising an opening (78a, 78b), through which a fluid can be introduced, the housing (52) comprising a reaction window (66a) and a temperature detection window (66b) arranged in a manner physically distanced therefrom, the reaction window (66a) transmitting the first electromagnetic radiation (E1) and the second electromagnetic radiation (E2), and it being possible for infrared radiation (I) to penetrate through the detection window (66b), the detector module (54) comprising: - a radiation source (82), which is designed to emit the first electromagnetic radiation (E1), - a radiation detector (86), which is designed to detect the second electromagnetic radiation (E2), and - an infrared detector (90), which is designed to detect the infrared radiation (I) emitted by the temperature detection layer body (64) through the temperature detection window (66b). According to the invention the reaction layer body (62) and the temperature detection layer body (64) are formed separately from one another.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
86.
PIPETTING DEVICE FOR PULSED PIPETTING WITH A PIPETTING PISTON MOVEMENT REGULATED ON THE BASIS OF A DETERMINATION OF THE WORKING GAS PRESSURE
The invention relates to pipetting device (10) for the pulsed pipetting of dosing liquids in small dose volumes of less than 2 μΙ, wherein the pipetting device (10) comprises: a pipetting channel (11) at least partially filled with working gas (34), a pipetting tip (26), which is accessible through a pipetting opening (30), such that the volume of dosing liquid drawn into the receiving chamber through the pipetting opening (30) can be varied by means of a change in the pressure of the working gas in the receiving chamber, a pipetting piston (14) for changing the pressure of the working gas (34) and accommodated in the pipetting channel so as to be capable of movement along the pipetting channel (11), a motion drive (20) to drive the pipetting piston (14) for movement along the pipetting channel (11), a control device (24) for controlling the motion drive (20), and a pressure sensor (38) for determining the pressure of the working gas, wherein the control device (24) is designed to control the motion drive (20) in order to generate a pressure pulse in the pipetting channel (11) with a pulse duration of no longer than 40 ms on the basis of the pressure signal output by the pressure sensor (38) in such a manner that the pressure of the working gas (34) during the pulse follows a predefined working gas target pressure pulse characteristic.
A pipetting device has a pipetting channel extending along a channel path, in which a piston is accommodated to be movable along the channel path to change the pressure of a working gas that wets the piston on a dosing side facing the dosing liquid. The pipetting device includes a movement drive for driving the piston along the channel path and a control unit configured to operate the movement drive for pipetting a predetermined single dosing volume of less than 5 μl with the piston moving in the pipetting direction and its dosing side end face sweeping over a pipetting volume which is not less than 1.4 times greater than the single dosing volume, and subsequently moving in a counter pipetting direction and its dosing side end face sweeping over a counter pipetting volume, wherein not more than 50 ms elapse between beginning control signals.
The invention relates to a pipetting device (10) for dispensing small doses (36) of a metering liquid of not more than 1 μΙ in a pulsed manner from a larger metering liquid quantity (32) which is provided in the pipetting device (10) using a pressure-variable working gas (34), comprising the following: - a pipetting channel (11) which is at least partly filled with working gas (34), - a pressure-changing device (14, 22) for changing the pressure of the working gas (34), and - a controller (24) for actuating the pressure-changing device (14, 22). The controller (24) is designed to actuate the pressure-changing device (14, 22) relative to a pipetting channel (11) holding reference pressure required to hold the metering liquid quantity (32) still in order to generate an overpressure pulse in the pipetting channel (11) with a pulse duration of no more than 40 ms. According to the invention, the controller (24) is additionally designed to actuate the pressure-changing device (14, 22) relative to the holding reference pressure prior to generating the overpressure pulse in the pipetting channel (11) so as to generate a negative pressure.
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
89.
PERMANENT-MAGNET PISTON ASSEMBLY COMPRISING AN EXOSKELETON WHICH HOLDS PERMANENT-MAGNET ARRANGEMENTS FOR A PIPETTING APPARATUS
A permanent-magnet piston assembly (10) for a pipetting apparatus, wherein the piston assembly (10) extends along a piston axis (K) and has a plurality of permanent-magnet arrangements (14a-14m) which are arranged one behind the other along the piston axis (K) with alternately opposite polarization directions in such a way that, for in each case two permanent-magnet arrangements (14i, 14j) which immediately follow one another along the piston axis (K), the magnet poles, which are closest to one another along the piston axis (K), of different permanent-magnet arrangements (14a-14m) which follow one another are the same, is characterized in that the piston assembly (10) comprises an enveloping tube (12) which extends along the piston axis (K) as tube axis (H) and in which the plurality of permanent-magnet arrangements (14a-14m) are held.
The invention relates to a pipetting device for aspirating and dispensing metering liquids, comprising the following: - at least one guide tube (30) which extends along a cylinder axis (Z), said cylinder axis (Z) defining an axial direction that runs along the longitudinal direction of the cylinder axis, a radial direction that runs orthogonally thereto, and a circumferential direction that runs circumferentially around the cylinder axis, - a piston (10) which is received in the guide tube (30) in an axially movable manner relative to the guide tube, - a coupling formation which is designed to temporarily or permanently couple a pipetting tip, and - a drive device (32) for driving the piston (10) in an axial direction relative to the guide tube (30), wherein the guide tube (30) has a coupling-side longitudinal end (48) which is positioned closer to the coupling formation and a maintenance-side longitudinal end (50) which is opposite the coupling-side longitudinal end (48) and which is positioned farther from the coupling formation. The piston (10) comprises at least one permanent magnet (14a,... 14m), and the drive device (32) has a coil assembly (32) which at least partly surrounds the guide tube (30) in the circumferential direction and which can be energized. The maintenance-side longitudinal end (50) of the guide tube (30) is open or is closed in an openable manner by a lid (52) which is intended to be releasable such that a piston (10) removal longitudinal end (54) positioned closer to the maintenance-side longitudinal end (50) of the guide tube (30) can be moved axially out of the guide tube by an external magnetic field.
What is described is an oxygen-permeable layer for detection of molecular oxygen, wherein the layer includes a carrier material encompassing at least one particle, wherein the carrier material is polyvinylidene fluoride or a copolymer of polyvinylidene fluoride and the particle comprises a polymer or a copolymer, wherein the polymer or copolymer of the particle includes a chemically covalently bonded indicator compound for detection of molecular oxygen. Additionally described is a multilayer system for detection of molecular oxygen. Also described are a process for producing the layer, and the use of the layer or of the multilayer system for detection of molecular oxygen.
C08L 27/16 - Homopolymers or copolymers of vinylidene fluoride
C09D 127/16 - Homopolymers or copolymers of vinylidene fluoride
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
92.
MAGNETIC ISOLATING APPARATUS WITH NON-PHYSICAL COUPLING BETWEEN A MAGNET ARRANGEMENT AND THE MOVEMENT DRIVE OF SAID MAGNET ARRANGEMENT
A magnetic isolating apparatus (10) for isolating magnetic particles (66) from a suspension has an immersion section (30) which is designed to be temporarily immersed in the suspension, a guide apparatus (16) which extends along a guide path (F), a magnet arrangement (18) which is guided by the guide apparatus (16) such that it can be moved between an active position which is situated close to the immersion section (30) and an inactive position which is positioned further away from the immersion section (30) along the guide path (F), so that a magnetic field in the region of the immersion section (30) can be changed by moving the magnet arrangement (18) between the active position and the inactive position, and a drive apparatus (22, 50) by which the magnet arrangement (18) can be driven to move at least in a direction between the active position and the inactive position, wherein the drive apparatus (22, 50) is coupled in a non-physical manner to the magnet arrangement (18) by a force field and/or a fluid so as to transmit drive force.
An autonomous device for detecting characteristics of a medium to be measured is disclosed. The device includes a sensor, a first microcontroller and a second microcontroller. The first microcontroller has a memory which is not resistant against gamma radiation during the sterilization of the device and the second microcontroller has a memory which is resistant against gamma radiation during the sterilization of the device.
G11C 11/412 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using semiconductor devices using transistors forming cells with positive feedback, i.e. cells not needing refreshing or charge regeneration, e.g. bistable multivibrator or Schmitt trigger using field-effect transistors only
A61L 2/00 - Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lensesAccessories therefor
B65B 55/16 - Sterilising contents prior to, or during, packaging by irradiation
94.
PIPETTING DEVICE HAVING A DISPLACEABLE PIPETTING CHANNEL HAVING ENLARGED SUPORTING LOCATION SPACING
The invention relates to a pipetting device (10) comprising a guide frame (12) having a first linear guide rail (52) and having a second linear guide rail (56), the first and the second linear guide rail (52, 56) extending parallel to each other along a displacement axis (VL) and being provided orthogonally with respect to the displacement axis (VL) spaced apart from each other, and comprising a pipetting channel (14), which extends along a preferably orthogonal channel axis (K14), which is not parallel to the displacement axis (VL) and which is displaceably guided along the displacement axis (VL) by a first supporting component (54) on the first linear guide rail (52) and by a second supporting component (58) on the second linear guide rail (56). Said pipetting device is characterized in that the first and the second supporting component (54, 58) are arranged along the displacement axis (VL) at a distance (A) from each other.
A fluid supply interface (10) has: • - a supply coupling formation, a discharge coupling formation, consumer coupling formation, a fluid duct, a supply valve, a discharge valve • which connects the supply coupling formation, the discharge coupling formation and the consumer coupling formation (104) to one another, • - a supply valve (64, 66, 68, 70, 72), by way of which the supply coupling formation (20, 22, 24, 26, 28) can be flowed through by fluid in a manner which is dependent on the position thereof or is shut off for a throughflow, • wherein the supply valve (64, 66, 68, 70, 72) is preloaded into a shut-off position which prevents the throughflow, and wherein the discharge valve (94, 96) is likewise prestressed into a closed position which prevents the throughflow thereof, and is configured as a safety valve.
The invention relates to a fluid supply interface (10), having: at least one supply coupling formation (20, 22, 24, 26, 28) for coupling at least one disposal decoupling formation, at least one consumer coupling formation (104) on the fluid supply interface (10), a fluid channel (16), which connects the at least one supply coupling formation (20, 22, 24, 26, 28), the at least one disposal coupling formation (82, 84) and the at least one consumer coupling formation (104) to each other, at least one supply valve, at least one disposal valve, wherein the fluid supply interface is coupled to a backwashing device (110), through which one and the same fluid can be driven in the fluid channel (16) for flow in opposite directions.
A fluid supply interface includes a line component having a first coupling formation for the temporary coupling of a first fluid channel, a second coupling formation for the temporary coupling of a second fluid channel, and a third coupling formation for the temporary or permanent coupling of a third fluid channel, each of said coupling formations being penetrated by a fluid line section, wherein in the line component, a fluid line assembly is formed, by means of which each fluid line section of the first, second and third coupling formations is or can be connected to each fluid line section of the other two coupling formations for the purpose of fluid transport.
The invention relates to a method for calibrating biomass sensors operating with impedance spectroscopy, which are designed to detect information about the quantity and/or size of living cells in a biomass by means of an electric field with a periodically changing field direction, said method comprising the following steps: providing a calibration suspension comprising an electroconductive viscous flowable or viscoelastic carrier substance and electroconductive solid body particles and/or semiconductor solid body particles incorporated therein, particularly according to one of the claims 10 to 19; producing an electric field acting on the calibration suspension, with a periodically changing field direction; detecting at least one respective permittivity value representing a permittivity of the calibration suspension, for at least two electric fields of differing frequency in terms of the field direction change; determining a difference value representing a difference between the detected permittivity values; and comparing the difference value with a reference value associated with the calibration suspension.
FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (Germany)
Inventor
Kissling, Tom
Grosch, Jens
Zumstein, Thomas
Traube, Andrea
Etzold, Carsten
Seiler, Tobias
Abstract
The invention relates to a cell separation device (10), comprising a container (12) for holding a cell suspension and a line (14) connected to the container (12) for conducting cell suspension from the container (12), wherein the line (14) extends along an imaginary line path (L) passing centrally through the line (14), wherein the line path (L) in the line (14) defines an axial direction (A) extending along the line path (L), a radial direction (R) orthogonal to the line path (L), and a circumferential direction (U) extending around the line path (L), wherein at least one section of the line (14), as a turbulence flow section (32), has a flow formation (26) that produces a turbulent cell suspension flow. Said cell separation device is characterized in that the flow formation (26) has at least two formation axial sections (34, 36), which are located one behind the other axially and of which the one is designed to accelerate a cell suspension flowing through the line (14) axially away from the container (12) in the circumferential direction (U) in a first directional sense and the other is designed to accelerate the cell suspension in the circumferential direction (U) in a second directional sense opposite the first directional sense.
The invention relates to a sample processing system and method for processing biological samples, comprising a sample processing device having: a receiving plate, which is arranged substantially horizontally in a plane; a first and second working arm, which can move relative to the receiving plate and extend substantially parallel to each other in a second direction (Y) over the receiving plate; at least one pipetting device mounted on the first working arm, which is movable in the second direction (Y) and in a third direction (Z) orthogonal in relation to the first and second direction (X, Y); at least one gripping device, mounted on the second working arm, with grippers that can be rotated around a gripper axis of rotation (GA) parallel to the third direction (Z); and a control device for controlling the pipetting device and the gripping device.
