LABORATORY MODULE COMPRISING A DELIVERY TRANSPORT DEVICE WITH TWO DELIVERY RECEIVING DEVICES, EACH OF WHICH IS DESIGNED TO RECEIVE AT LEAST ONE RESPECTIVE LABORATORY OBJECT
The invention relates to a laboratory module (56) comprising a delivery transport device (96), which can be moved along a delivery transport path (98), for transporting at least one laboratory object (158a, 158b, 158c) within the laboratory module (56) along the delivery transport path (98), said delivery transport device (96) having a delivery receiving assembly (104) designed to receive at least one laboratory object (158a, 158b, 158c). According to the invention, the delivery receiving assembly (104) has two delivery receiving devices (104a, 104b), each of which is designed to receive a respective laboratory object (158a, 158b, 158c) for a transport process carried out by means of the delivery transport device (96), wherein the two delivery receiving devices (104a, 104b) can be moved together along the delivery transport path (98).
The invention relates to a laboratory module (56a, 56b, 56c) comprising a transport assembly (99). The transport assembly (99) has a first and a second transport device (68, 96), wherein the first transport device (68) has a first receiving device (72), and the second transport device (96) has a second receiving device (102). The first receiving device (72) can be moved along a transport path (70), and the second receiving device (102) can be moved along a second transport path (98) which differs from the first transport path (70). The transport assembly (99) has a transfer region (176) in which the transport assembly (99) is designed to transfer a laboratory object (158a, 158b, 158c) between the first and second receiving device (72, 102). At least one of the first and second receiving devices (72, 102) can be driven so as to carry out a transfer movement at least in the transfer region (176), and the first and second receiving device (72, 102) can be moved past each other along a relative movement transfer path (TRB) in the transfer region (176). The transfer movement cancels a receiving engagement between the laboratory object (158a, 158b, 158c) and the receiving device which is dispensing the laboratory object and produces a receiving engagement between the laboratory object and the receiving device which is receiving the laboratory object.
The invention concerns a laboratory module rack (36) comprising at least two laboratory base modules (42) at a lower, base module level (38) and at least two laboratory working modules (56) at an upper, working module level (40) arranged above the base module level (38), wherein each laboratory working module (56) comprises a processing device (60) and a conveying assembly (99) having a first and a second conveying device (68, 96) for conveying a laboratory object at least towards the processing device (60), wherein the first conveying device (68) has a first receiving device (72) and the second conveying device (96) has a second receiving device (102) for receiving the laboratory object, for conveying the laboratory object, wherein the conveying assembly (99) has a transfer region (176) in which the conveying assembly (99) is configured to transfer a conveyed laboratory object between the first and second conveying devices (68, 96), wherein the at least two laboratory working modules (56) succeed one another along the direction of movement of the first conveying device (70) and have a common first conveying device (68) and in each case their own second conveying device (96) and in each case their own transfer region (176).
The invention relates to a laboratory module (56), comprising: a) a pipetting device (64) for aspirating and dispensing liquids; b) a set of different laboratory objects (158a, 158b, 158c), comprising a source vessel (158a), a target vessel (158c) and a pipette tip assembly (158b) having at least one pipette tip (184) as different laboratory objects (158a, 158b, 158c); and, c) a delivery transport device (96) which can be moved along a delivery transport path (98) for transporting laboratory objects (158a, 158b, 158c) at least into the working region (186) of the pipetting device (64), wherein the delivery transport device (96) is designed to transport a first sub-selection (157) comprising one or two different laboratory objects (158c), selected from the source vessel (158a), the target vessel (158c) and the pipette tip assembly (158b), from a transfer station (178) of the laboratory module (56) into the working region (186) of the pipetting device (64), and is further designed to transport a second sub-selection (158) comprising a laboratory object (158a, 158b) not contained in the first sub-selection (157), selected from the source vessel (158a), the target vessel (158c) and the pipette tip assembly (158b), from a supply station (182), which is different to the transfer station (178), into the working region (186) of the pipetting device (64).
A respiratory device including a breathing gas source assembly, a flow change device, a breathing gas line assembly, a sensor assembly, and a control device with a data memory, the control device being connected for signal transmission to the data memory and to the sensor assembly, the control device being designed, in a normal respiratory operation, not to bring about a machine-triggered breathing stroke starting from a previous breathing stroke before a predetermined normal time interval has elapsed, the control device being further designed to identify, on the basis of data from the sensor assembly, a spontaneous respiratory effort of the patient, the control device being further designed, if it has identified at least a predetermined plurality of spontaneous respiratory efforts of the patient within a predetermined monitoring period, to switch to a challenge respiratory operation, in which, instead of the normal interval, a challenge interval lasting for a longer time is used.
A fluid conveying device (65) for introducing fluid into and/or removing fluid from an esophageal catheter (48) which is insertable into an esophagus (34) and has a balloon probe (46) for determining an esophageal balloon pressure, comprising: a measuring fluid port (90), which is configured to be coupled to a distal end (48b) of the esophageal catheter (48) such that, in the coupled state, fluid is introducable into the esophageal catheter (48) and/or removable from the esophageal catheter (48) via the measuring fluid port (90); a pump device (100) having at least one fluid pump (102), wherein the pump device (100) is configured to convey fluid in at least a first conveying direction, and a switching valve (106) which is associated with the at least one fluid pump (102) and which is switchable at least between a first position and a second position. The at least one fluid pump (102) is in the form of a micropump or diaphragm pump.
The invention relates to a ventilation apparatus (2), preferably a high-flow ventilation apparatus (2), for ventilation, preferably nasal ventilation, of a patient, the respiratory apparatus comprising: an air inlet (10) which is designed to supply ambient air to the ventilation apparatus (2); an oxygen inlet (8) which is designed to supply oxygen gas to the ventilation apparatus (2); a mixing section (34) which is designed to receive ambient air from the air inlet (10) and oxygen gas from the oxygen inlet (8), to mix the ambient air and the oxygen gas with each other, and to deliver oxygen-enriched air as a ventilation gas flow into a ventilation gas flow path (39); an oxygen measuring device (32, 40a, 40b) which is designed to determine the oxygen content in the ventilation gas flow downstream of the mixing section (34) and to provide said oxygen content as a measurement result; and/or a ventilation gas pressure sensor (45) which is designed to determine the pressure of the ventilation gas flow downstream of the mixing section (34) and to provide said pressure as a measurement result; and/or a ventilation gas temperature sensor (42) which is designed to determine the temperature of the ventilation gas flow downstream of the mixing section (34) and to provide said temperature as a measurement result; and/or a ventilation gas humidity sensor (43) which is designed to determine the humidity in the ventilation gas flow downstream of the mixing section (34) and to provide said humidity as a measurement result; and an integrated combination sensor (60) which is designed to measure a thermal conductivity, a pressure, a temperature, and a humidity of the ventilation gas flow downstream of the mixing section (34), to determine an oxygen content of the ventilation gas flow based on the measured thermal conductivity taking into consideration the measured pressure, the measured temperature, and the measured humidity, and to provide the oxygen content thus determined, the measured pressure, the measured temperature, and the measured humidity as measurement results; and a monitoring device (66) which is designed to compare the measurement results provided by the oxygen measuring device (32, 40a, 40b), by the ventilation gas pressure sensor (45), by the ventilation gas temperature sensor (42), and/or by the ventilation gas humidity sensor (43) with the corresponding measurement results that have been provided by the integrated combination sensor (60); and to output an alarm signal if at least one of the measurement results received from the oxygen measuring device (32, 40a, 40b), from the ventilation gas pressure sensor (45), from the ventilation gas temperature sensor (42), and/or from the ventilation gas humidity sensor (43) differs from the corresponding measurement result that has been provided by the integrated combination sensor (60) by more than a predefined maximum difference value.
The invention relates to a ventilation apparatus (2) comprising: an air inlet (10) which is designed to supply ambient air to the ventilation apparatus (2); an oxygen inlet (8) which is designed to supply oxygen gas to the ventilation apparatus (2); a mixing section (34) which is designed to receive ambient air from the air inlet (10) and oxygen gas from the oxygen inlet (8), to mix the ambient air and the oxygen gas with each other, and to output oxygen-enriched air as a ventilation gas flow into a ventilation gas flow path (39); an oxygen regulation valve (30) which is provided between the oxygen inlet (8) and the mixing section (34) and which makes it possible to regulate a flow of the oxygen gas from the oxygen inlet (8) into the mixing section (34); and an integrated combination sensor (60) which is designed to measure a thermal conductivity, a pressure, a temperature, and a humidity of the ventilation gas flow downstream of the mixing section (34), to determine the oxygen content of the ventilation gas flow based on the thermal conductivity taking into consideration the measured pressure, the measured temperature, and the measured humidity, and to provide the oxygen content as measurement results. The ventilation apparatus (2) also has a monitoring device (66) which is designed: to receive the measurement results provided by the oxygen measuring device (32, 40a, 40b), by the ventilation gas pressure sensor (45), by the ventilation gas temperature sensor (42), and/or by the ventilation gas humidity sensor (43) and by the integrated combination sensor (60); to compare the measurement result of the oxygen content in the ventilation gas flow received from the integrated combination sensor (60) with a predefined oxygen content in the ventilation gas flow; and to control the oxygen regulation valve (30) in order to adjust the oxygen content in the ventilation gas flow if the measurement result of the oxygen content in the ventilation gas flow, which measurement result is received from the integrated combination sensor (60), differs from the predefined oxygen content in the ventilation gas flow.
The present invention relates to an ATR sensor (10) for determining the concentration of glucose in a fluid, comprising a sensor housing (12) in which at least the following sensor components are accommodated: an infrared radiation source (22); an ATR element (24) designed to transmit, with total internal reflection on at least one boundary surface of the ATR element (24), infrared radiation emitted by the infrared radiation source (22); at least one infrared detector (40) designed to sense infrared radiation transmitted by the ATR element (24) and to output a corresponding infrared measurement signal; and at least two infrared bandpass filters (36a, 36b) which are disposed between the ATR element (24) and the infrared detector (40), each of the infrared bandpass filters (36a, 36b) being designed such that it allows only infrared radiation having a wave number within a predefined wave number range (F1, F2) to pass. At a temperature of 37°C, a first of the infrared bandpass filters (36a) allows infrared radiation having a wave number in a first wave number range (F1) from 1005 cm-1to 1025 cm-1to pass. At a temperature of 37°C, a second of the infrared bandpass filters (36b) allows infrared radiation having a wave number in a second wave number range (F2) from 1075 cm-1 to 1095 cm-1 to pass.
G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
10.
SLIM ATR SENSOR WITH A MEASURING AND REFERENCE SIGNAL
An ATR sensor having a sensor housing, wherein at least the following sensor components are accommodated in the sensor housing: an infrared radiation source, an ATR element, wherein the ATR element is designed to transmit infrared radiation via reflection on at least one boundary surface of the ATR element; an infrared measuring sensor which detects infrared radiation emitted by the infrared radiation source after its transmission via the ATR element, and which outputs a measuring detection signal depending on the infrared radiation detected by the infrared measuring sensor; and infrared reference sensor which detects infrared radiation emitted by the infrared radiation source that is not transmitted by the ATR element, and which outputs a reference detection signal depending on the infrared radiation detected by the infrared reference sensor, the infrared radiation source being designed and arranged to radiate an infrared measuring radiation portion detected by the infrared measuring sensor in a measuring radiation direction, and to simultaneously radiate an infrared reference radiation portion detected by the infrared reference sensor in a reference radiation direction that is different to the measuring radiation direction.
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having reaction vessels (88) which are arranged in a matrix pattern in first rows (88a) and second rows (88b), wherein the first rows (88a) are parallel to one another, the second rows (88b) are parallel to one another, and the first and second rows intersect one another, wherein each reaction vessel (88) of the plurality of reaction vessels (88) arranged in a matrix pattern is located at an intersection point of a first and a second row (88a, 88b), wherein each reaction vessel (88) has an inlet port (104) and, at a distance therefrom, an outlet port (116), and ii. a magnetic device (70) having a movable magnet carrier assembly (72), wherein the number of matrix magnets (94) is less than the number of reaction vessels (88) of the plurality of reaction vessels (88), wherein two matrix magnets (94) are adjacent to each reaction vessel (88) of the plurality of reaction vessels (88). The magnet carrier assembly (72) carries a number of matrix magnets (94) that is greater than the sum of the first and second rows (88a, 88b), wherein the matrix magnets (94) each have a polarisation direction (94a) that is nonparallel to both the first rows (88a) and the second rows (88b) and that is non-orthogonal to both the first rows (88a) and the second rows (88b).
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having a reaction vessel assembly (86) with at least one reaction vessel (88), wherein the at least one reaction vessel (88) has an inlet end (102) with an inlet port (104) and an outlet end (106) that is located at a distance from the inlet end (102) and has an outlet port (116), ii. a dosing device (62a) having at least one dosing port (188) for delivering liquid (109) into at least one reaction vessel (88) of the reaction vessel device (18), wherein the dosing device (62a) is designed to deliver liquid via the dosing port (188) through the inlet port (104) in the at least one reaction vessel (88), and iii. a pressure modification device (62b), wherein the pressure modification device (62b) is designed to modify a gas pressure difference between an internal gas pressure in at least one reaction vessel (88) of the reaction vessel device (18) and an external gas pressure outside the at least one reaction vessel (88). The pressure modification device (62b) and the dosing device (62a) together form a combined supply device (62) that can be moved along a supply path (BP) and has: at least one gas outlet opening (190), which is distinct from the dosing port (188), for releasing gas; and the at least one dosing port (188).
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having a reaction vessel assembly (86) with at least one reaction vessel (88), wherein the at least one reaction vessel (88) has an inlet port (104) and, at a distance therefrom, an outlet port (116); ii. a useful-liquid receiving device (50) for receiving liquid dispensed through the outlet port (116) in the at least one reaction vessel (86), iii. a waste-liquid receiving device (46) for receiving liquid discharged through the outlet port (116) in the at least one reaction vessel (86), iv. a magnetic device (70) for generating a magnetic field in the at least one reaction vessel (88), v. a pressure modification device (62b) for modifying a gas pressure in at least one reaction vessel (88), and vi. a dosing device (62a) for delivering liquid (109) into at least one reaction vessel (88) of the reaction vessel device (18). Each of the devices listed in i. to v. is accommodated in an apparatus housing (12) of the liquid handling apparatus (10) so as to be movable relative to each of the other devices listed in i. to v., and each of the devices listed in i. to iv. and vi. is accommodated in the apparatus housing (12) so as to be movable relative to each of the other devices listed in i. to iv. and vi.
The invention relates to an automated liquid handling apparatus (10) comprising: i. a reaction vessel device (18) having a reaction vessel holder (20) and at least one reaction vessel (88) for placement in the reaction vessel holder (20), wherein the at least one reaction vessel (88) has an inlet port (104) and, at a distance therefrom, an outlet port (116), ii. a useful-liquid receiving device (50) for receiving liquid dispensed through the outlet port (116) in the at least one reaction vessel (88), iii. a waste-liquid receiving device (46) for receiving liquid discharged through the outlet port (116) in the at least one reaction vessel (88), iv. a pressure modification device (62b), wherein the pressure modification device (62b) is designed to modify the internal gas pressure in at least one reaction vessel (88) of the reaction vessel device (18), v. a dosing device (62a) having at least one dosing opening (188) for delivering liquid (109) into at least one reaction vessel (88) of the reaction vessel device (18), and vi. a control device (40). The automated liquid handling apparatus (10) comprises a container sensor (92) which detects the arrangement of at least one reaction vessel (88) in the reaction vessel holder (20) and outputs a corresponding detection result to the control device (40).
A reaction vessel (88) for an automated liquid handling device extends along a virtual vessel axis (BA) between an input end (102), having an input opening (104), and an output end (106), having an output channel (108), wherein between the input opening (104) and the output channel (108) a receiving volume (112) is formed, wherein the output channel (108) has an inlet opening (114) on its channel end closer to the receiving volume (112) and has an output opening (116) on its channel end closer to the external environment of the reaction vessel (88), wherein the distance (D) to be measured along the vessel axis (BA) between the inlet opening (114) and the input opening (104) forms a reference dimension (RD) of the reaction vessel (88). A second tapering region (112b) has, at least in an inlet portion (126) closer to the inlet opening (114) than to the first tapering region (112a), a second taper angle (α2) in the range from 40° to 50° between the vessel axis (BA) and the inner wall surface (110a) over an axial extent of at least 3 % of the reference dimension (RD).
The invention relates to an automated liquid handling apparatus (10) for handling liquids (109), said apparatus comprising: i. a reaction vessel device (18) having a reaction vessel assembly (86) with a plurality of reaction vessels (88), wherein each reaction vessel (88) of the plurality of reaction vessels (88) has an outlet end (102) with an outlet port (104), ii. a waste-liquid receiving device (46) for receiving liquid discharged through the outlet port (104) in the reaction vessels (88) as handling waste, wherein the waste-liquid receiving device (46) comprises a waste collection container (45) with a receiving volume (45a) for receiving the handling waste from the plurality of reaction vessels (88) and comprises a waste container holder (28), and iii. a pressure modification device (62b), wherein the pressure modification device (62b) is designed to modify a gas pressure difference between an internal gas pressure in at least one reaction vessel (88) of the reaction vessel device (18) and an external gas pressure outside the at least one reaction vessel (88). The waste collection container (45) has a tray body (45c) and a container lid (45d) which is arranged on the tray body and covers at least most of the collection volume (45a) of the waste collection container.
The invention relates to a method for separating HMW DNA and/or UHMW DNA from a carrier member (8), to which the DNA is releasably attached, using a centrifugation container set (2) having at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and at least one collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) is separably plugged on the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) has a container wall (14), which surrounds a container interior (12), and a container base (16) having at least one outflow opening (20), wherein the outflow opening (20) forms at least one flow path (24) from the container interior (12) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel interior (42) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) for a fluid to be centrifuged, wherein the at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and the at least one collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) are geometrically coordinated with one another such that there is a free distance (a) from an outlet opening (22) of the outflow opening (20) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel base (44) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) in the direction of a main extension axis (H1) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h), wherein the free distance (a) is selected such that possible threads of the DNA detach from the outlet opening (22).
A breathing tube which is designed for channelling inspiratory and/or expiratory breathing gas during at least partial artificial respiration of a patient, defines a virtual breathing-gas-flow path, which is imagined to pass centrally through the tube and along which the breathing tube channels the breathing gas. The breathing tube has a filter carrier in which is formed a filter-accommodating space, which has the breathing-gas-flow path passing through it and in which a breathing-gas filter, which can have breathing gas flowing through it, can be accommodated in an interchangeable manner. The filter carrier has a wall which encloses the filter-accommodating space at a radial distance from the virtual breathing-gas-flow path and has an introduction opening, which is arranged at a radial distance from the virtual breathing-gas-flow path and through which the breathing-gas filter can be introduced into the filter-accommodating space and can be moved into its operationally ready operating position.
A characterization system for automated ex vivo characterization of an esophageal catheter with a balloon probe for determining an esophageal pressure comprises an arrangement for filling the esophageal catheter with a measuring fluid before placing the esophageal catheter in an esophagus, a pressure sensor for detecting a pressure (peso) prevailing in the esophageal catheter; a device for determining at least one property that is characteristic of the esophageal catheter on the basis of the pressure (peso) detected in the esophageal catheter; a storage device for storing at least the property characteristic of the esophageal catheter; and at least one controller for controlling the characterization system, the controller being designed such that the characterization system performs a method comprising at least the following steps: filling the esophageal catheter with a measuring fluid ex vivo, in particular before placing the esophageal catheter in an esophagus; detecting a pressure prevailing in the esophageal catheter; determining at least one property characteristic of the esophageal catheter on the basis of the detected pressure; and storing at least the property characteristic of the esophageal catheter.
A turbidity sensor for detecting clouding of a fluid by particulates contained in the fluid, wherein the turbidity sensor includes a fluid detection region for the reception and metrological detection of fluid; a radiation source for emitting radiation into the fluid detection region; a first radiation sensor for detecting a first part of the radiation emitted by the radiation source; and a second radiation sensor, different from the first radiation sensor, for detecting a second part of the radiation emitted by the radiation source that is different from the first part, wherein at least a portion of the fluid detection region is located between the first radiation sensor and the second radiation sensor, the second radiation sensor is located in a beam path of the first part of the radiation emitted by the radiation source that is detected by the first radiation sensor.
The invention relates to an ATR sensor base assembly (10) comprising: - a measuring range assembly (14) comprising + an ATR element (26) and + a framing component (18) which frames the ATR element (26), wherein the ATR element (26) has a measurement interface (26a) which faces the external surroundings (U) of the measuring range assembly (14) and is accommodated on the framing component (18) in such a way that the measurement interface (26a) is exposed on the measuring range assembly (14) towards the external surroundings (U) of the measuring range assembly (14), - a porous separating component (22) which is designed to be detachably arranged on the measuring range assembly (14) so as to at least partially cover the measurement interface (26a), and - a holding component (20) which is designed to be detachably arranged on the measuring range assembly (14) so as to at least partially cover the porous separating component (22) and, when arranged, to exert a loading force (B) onto the separating component (22), which loading force acts in the direction of the measuring range assembly (14). According to the invention, the ATR sensor base assembly (10) comprises a magnet assembly (31) in such a way that the loading force (B) exerted onto the separating component (22) between the holding component (20) and the measuring range assembly (14) has at least one magnetic force component.
A method for determining a respiratory-gas content in a respiratory tract, which content is present in the respiratory tract of an at least partially artificially ventilated patient following a plurality of breaths performed with the involvement of a ventilation apparatus, wherein the plurality of breaths include at least one earlier number of breaths and at least one follow-up breath following the earlier number of breaths; wherein the earlier number of breaths include an earlier breath or a plurality of successive earlier breaths; wherein the method comprises quantitative detection of inspiratory and expiratory respiratory-gas flows by at least one respiratory-gas flow sensor and summation of detected inspiratory and expiratory flow values to form the respiratory-gas content in the respiratory tract; wherein a respiratory tract content starting value, at which the determination of the respiratory-gas content in the respiratory tract for the follow-up breath starts, depending on a difference in respiratory-gas amount between an inspiratory respiratory-gas amount supplied to the patient during an earlier number of breaths and an expiratory respiratory-gas amount output by the patient during the earlier number of breaths, is set to a reset starting value, which is closer to zero than to a difference value that quantitatively provides the respiratory-gas amount difference, or is set to a continuity starting value, which is closer to the difference value than to zero.
A connection plug (2) for connecting a pneumatic flow sensor (160) to a ventilator (110) comprises a plug body (10); a first passage (20) extending through the plug body (10) and having a first flow sensor-side pressure line port (24) and a first ventilator-side pressure sensor port (22); and a second passage (40) extending through the plug body (10) and having a second flow sensor-side pressure line port (44) and a second ventilator-side pressure sensor port (42); wherein the first ventilator-side pressure sensor port (22) is provided with a first electrical contact (26) and the second ventilator-side pressure sensor port (42) is provided with a second electrical contact (46), and wherein an electrical connection (60) is provided between the first electrical contact (26) and the second electrical contact (46).
A wall holder for an emergency ventilator arrangement having a basic structure which can be attached to a substantially flat wall and is designed for releasably receiving the emergency ventilator arrangement, wherein the basic structure has a receiving side, which is provided with receiving means for releasably receiving the emergency ventilator arrangement, and an installation side which is opposite the receiving side and, in a state attached to the wall and ready for operation, faces the wall, wherein the installation side defines a reference surface designed for contact with the wall, wherein the receiving means has a hanging structure permitting hanging of a hanging counter structure, and a locking device which is arranged at a distance along the reference surface from the hanging structure, wherein the locking device has a locking structure which is accommodated on the basic structure so as to be shiftable between an engagement preparation position and an engagement position, wherein, in the engagement position, the locking structure is designed to secure a locking counter structure of the emergency ventilator arrangement in a form-fitting manner, wherein the engagement preparation position differs from the engagement position.
F16M 13/02 - Other supports for positioning apparatus or articlesMeans for steadying hand-held apparatus or articles for supporting on, or attaching to, an object, e.g. tree, gate, window-frame, cycle
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
27.
EXPIRATION VALVE ASSEMBLY AND BREATHING GAS LINE ASSEMBLY COMPRISING SUCH AN ASSEMBLY
An expiration valve assembly for a ventilator, including an expiration channel which has, at one end, an expiration outlet and an inlet connection part that is designed to connect to an expiration breathing gas line and which, at its other end, has an expiration outlet, the expiration channel having an expiration valve; an inspiration channel which has, at one end, an inspiration inlet and an inlet connecting part that is designed to connect to a breathing gas source supplying inspiratory breathing gas, and which, at its other end, has an inspiration outlet and an outlet connecting part that is designed to connect to an inspiration breathing gas line; a control channel which branches off from the inspiration channel at a branch location and leads to the expiration valve in such a way that the expiration valve can be loaded by inspiratory breathing gas into a blocking position which blocks the flow of expiratory breathing gas; a one-way valve being arranged in the inspiration channel and permits a flow of inspiratory breathing gas in the inspiration direction from the inspiration inlet to the inspiration outlet and prevents a flow of breathing gas in the opposite direction.
The invention relates to a calibration system for automatically setting an intended operational filling of an esophageal catheter with balloon probe, which can be inserted into the esophagus, for determining an esophageal pressure, in particular for a ventilation device, comprising a device for filling the balloon probe with a measuring fluid after placing the balloon probe in the esophagus, a pressure sensor for detecting the esophageal pressure prevailing in the balloon probe, and a calibration controller which is designed such that it incrementally changes the amount of measuring fluid in the balloon probe, the calibration controller recording an esophageal pressure detected by the pressure sensor for each amount of measuring fluid in the balloon probe set incrementally as a measuring point in this way and assigning said esophageal pressure to the respective set amount of measuring fluid in the balloon probe. The calibration controller is designed such that, in order to approach the respective measuring points, it monotonically changes the amount of measuring fluid in at least two steps, starting from a start value until an end value is reached.
A switching-valve assembly having a housing, first and second source ports, an outlet port, a first gas-supply line connecting the first source port to the outlet port, a second gas-supply line connecting the second source port to the outlet port, a valve arrangement in the housing adjustable between a first operating state, in which it opens the first gas-supply line to allow respiratory gas to flow through and blocks the second gas-supply line, and a second operating state, in which it blocks the first gas-supply line and opens the second gas-supply line to allow respiratory gas to flow through, the switching-valve assembly in the form of a modular switching-valve assembly being stackable, by the housing having a first outer-surface portion for stacking and a second outer-surface portion for stacking, which is designed to as to be complementary to the first outer-surface portion for stacking, wherein a source port is designed as a sequence port such that, when the first and the second outer-surface portions for stacking are in stacked engagement with one another, proceeding from the outlet and the sequence port, gas-supply line portions extending into the housing are each connected to a continuous gas-supply line region.
The present invention relates to a radiation emission component (10) for the temperature-compensated optical detection of an oxygen content of a fluid (MF), wherein the radiation emission component (10) comprises a contact surface (18) wettable by the fluid (MF), and a coupling surface (24) different from the contact surface (18), wherein the radiation emission component (10) has a luminophore-containing region (14), wherein the luminophore is reachable by oxygen in a first portion (20) of the contact surface (18) for the quenching thereof, wherein the radiation emission component (10) has a temperature detection region (16) arranged offset along the contact surface (18) relative to the luminophore-containing region (14), and wherein the radiation emission component (10) has, in the temperature detection region (16), a main body (34) having a cutout (38) extending toward the contact surface (18), wherein the cutout (38) is covered by a base (42) comprising a base layer body (44; 144), wherein a surface of the base layer body (44) facing away from the cutout (38) forms a second portion (22) of the contact surface (18). The invention provides for the main body (34) and the base layer body (44) each to comprise plastics material, wherein the main body (34) and the base layer body (44) are integrally connected to one another by means of their respective plastics materials.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
31.
METHOD FOR THE QUALITY-ASSESSED METERING OF A METERING FLUID, AND PIPETTING DEVICE DESIGNED TO CARRY OUT THE METHOD
The present invention relates to a method for the quality-assessed metering by means of a pipetting device (10), the method comprising the following steps: - carrying out a metering process by moving a pipetting plunger (30), - recording the time curve of the working-gas pressure (44, 54) in a pipetting channel (12) during the metering process, - comparing the curve of the working-gas pressure (90) on the basis of the recorded time curve of the working-gas pressure (44, 64) with a predetermined target pressure value range (54, 74), and - outputting a quality assessment of the metering process on the basis of the result of the comparison step. According to the invention, in order to improve the quality assessment, the control device (38) carries out the following further steps while the pipetting channel (12) is filled exclusively with working gas as fluid: - carrying out corrective-pressure determination by moving the pipetting plunger (30), and - measuring a pressure of the working gas in the pipetting channel (12) as a corrective pressure during the corrective-pressure determination, wherein, prior to the comparison step, the control device (38) corrects the time curve of the working-gas pressure (44, 64) recorded during the metering process on the basis of the corrective pressure measured during the, so that the comparison step is carried out using the corrected time curve (90) of the working-gas pressure.
Proposed is an exchangeable pipette tip (10; 110; 210), wherein the pipette tip (10; 110; 210) extends along a channel axis (K), wherein the channel axis (K) defines an axial direction (a) running along the channel axis (K), radial directions (r) orthogonal with respect to the channel axis (K), and a circumferential direction (u) encircling the channel axis (K), wherein the pipette tip (10; 110; 210), at one axial longitudinal end thereof forming a coupling longitudinal end (12), has a coupling formation (40) which is designed for coupling to a counterpart coupling formation of a pipette device, wherein the pipette tip (10; 110; 210), at the longitudinal end thereof situated axially opposite the coupling longitudinal end (12) and forming a dosing longitudinal end (14), has a pipette opening (34) that is communicatively connected to a receiving space (36) designed for receiving liquid that is to be dosed, wherein the receiving space (36) of the pipette tip (10; 110; 210) is designed to taper toward the pipette opening (34), characterized in that at least one axial portion of the receiving space (36) is concave and forms a concave axial portion (26), such that an inner wall (11b) of the pipette tip (10; 110; 210) that radially delimits said portion is curved about at least one curvature axis (K3) running transversely with respect to the channel axis (K).
The invention relates to an electrochemical sensor having a porous diaphragm and an electrolyte formulation that comprises at least one solvent, at least one electrolyte from the group of alkali metal salts and at least one alkaline earth metal ion, and to an electrolyte formulation.
The invention relates to an ATR sensor (10) comprising a sensor housing (12), wherein at least the following sensor components are accommodated in the sensor housing (12): an infrared radiation source (22), an ATR element (24), wherein the ATR element (24) is designed to transmit infrared radiation via reflection on at least one boundary surface of the ATR element (24); an infrared measuring sensor (32) which detects infrared radiation emitted by the infrared radiation source (22) after its transmission via the ATR element (24), and which outputs a measuring detection signal depending on the infrared radiation detected by the infrared measuring sensor (32); and infrared reference sensor (34) which detects infrared radiation emitted by the infrared radiation source (22) that is not transmitted by the ATR element (24), and which outputs a reference detection signal depending on the infrared radiation detected by the infrared reference sensor (34). According to the invention, the infrared radiation source (22) is designed and arranged to radiate an infrared measuring radiation portion (56) detected by the infrared measuring sensor (32) in a measuring radiation direction, and to simultaneously radiate an infrared reference radiation portion (60) detected by the infrared reference sensor (34) in a reference radiation direction that is different to the measuring radiation direction.
G01N 21/3577 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
36.
COMBINATION ELECTRODE COMPRISING A DIAPHRAGM HAVING A CROSS-LINKED HYDROGEL, AND METHOD FOR PRODUCING THE COMBINATION ELECTRODE
The invention relates to a combination electrode (1) for measuring a working fluid, having a working electrode (2), a reference electrode (3), a diaphragm (10), and a first electrically conductive fluid (6), which is in contact with the reference electrode (3) and the diaphragm (10) such that the diaphragm (10) is connected to the reference electrode (3) in an electrically conductive manner via the first electrically conductive fluid (6), the diaphragm (10) having a cross-linked hydrogel and is stabilised by at least one support element. The invention also relates to a method for producing the combination electrode (1).
A spectroscopic sensor assembly for detecting at least one predefined analyte constituent of a measurement fluid, the sensor assembly including a sensor housing; a radiation source; a detector device; a barrier assembly, which is transmissive for measurement radiation and is impermeable to the analyte constituent; a polymer matrix, which absorbs and releases the analyte constituent; a reflector assembly, which has a signal side facing the polymer matrix and facing the barrier assembly; wherein the reflector assembly has at least one passage extending through the reflector assembly, through which passage the analyte constituent is exchanged between a measurement environment and the polymer matrix, which polymer matrix is located on the signal side of the reflector assembly; and wherein the reflector assembly reflects incident measurement radiation back toward the apparatus portion; the sensor assembly having a spacing means different from the polymer matrix, the spacing means being designed to prevent the reflector assembly from approaching the barrier assembly.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 21/85 - Investigating moving fluids or granular solids
38.
METHOD FOR ASSIGNING A PIPETTE TIP TO A PIPETTE TIP CLASS ON THE BASIS OF THE PNEUMATIC BEHAVIOUR THEREOF
A method for assigning a pipette tip to a certain class of pipette tips from a plurality of different pipette tip classes, the method including the following steps: coupling the pipette tip to a gas displacement device such that a device-side volume formed in the gas displacement device and a tip-side volume formed by the pipette tip communicate with each other, and thereby forming a measuring volume including the communicating volumes of the device-side volume and the tip-side volume; operating the gas displacement device and thereby changing the gas pressure in the measuring volume; detecting the gas pressure in the measuring volume over a detection time period; determining at least one absolute value of at least one characteristic variable characterizing the detected gas pressure; comparing the at least one determined absolute value with at least one predetermined calibration value; and, depending on the comparison result, assigning the pipette tip to a pipette tip class and outputting an item of class assignment information representing the assigned pipette tip class.
An emergency ventilator for artificially ventilating patients in the event of a medical emergency, having: —a housing with an ambient air suction opening and a ventilating gas outlet opening and —a fan which is designed and is arranged in the housing so as to convey ambient air from the ambient air suction opening to the ventilating gas outlet opening, wherein the fan includes a fan housing with an air conveyor which can be moved relative to the fan housing, and the fan housing is arranged in the housing in a fixed manner thereto; the fan housing is secured to the housing with the interposition of a heat conducting body, the heat conducting body including or being made of a material which is selected from light metal, nonferrous metal, and/or a plastic filled with a heat-conductive filler material.
A ventilator device for at least supporting artificial ventilation of patients, including:
a device housing,
a functional arrangement received in the device housing, the functional arrangement including, as functional units, at least one portion of a breathing gas line, a pressure-changing device for changing a breathing gas pressure in the breathing gas line, and a control device for controlling the operation of at least one pressure-changing device, and
an input/output device, which is arranged on the device housing, is accessible from outside the device housing in order to be operated, and is intended for inputting data and/or control commands at the control device and/or for outputting data and information, the input/output device being connected to the control device for signal transmission; the ventilator device having a frame, the device housing with the input/output device arranged thereon being received on the frame so as to be rotatable about a virtual rotation axis.
The present invention relates to a respiratory device (10), the respiratory device (10) comprising: - a breathing gas source assembly (15), - a flow change device (16), - a breathing gas line assembly (30), - a sensor assembly (27, 44, 52), - and a control device (18) with a data memory (19), the control device (18) being connected for signal transmission to the data memory (19) and to the sensor assembly (27, 44, 50), the control device (18) being designed, in a normal respiratory operation, not to bring about a machine-triggered breathing stroke starting from a previous breathing stroke before a predetermined normal time interval (58) has elapsed, the control device (18) being further designed to identify, on the basis of data from the sensor assembly (27, 44, 50), a spontaneous respiratory effort of the patient (12), the control device (18) being further designed, if it has identified at least a predetermined plurality of spontaneous respiratory efforts of the patient (12) within a predetermined monitoring period, to switch to a challenge respiratory operation, in which, instead of the normal interval (58), a challenge interval lasting for a longer time is used.
A ventilation device for an at least supportive artificial ventilation of patients including a device housing, a functional assembly, which is received in the device housing in an operational position and which has at least one controller as a functional unit, and an input/output device which is arranged on the device housing in an assembly position, the input/output device is connected to the controller through an opening in the device housing so as to transmit signals, and the input/output device is secured directly to the functional assembly so as to prevent removal of the input/output device from its assembly position away from the device housing in a lifting direction.
A ventilator device for at least supporting artificial ventilation of patients, having: —a device housing, a functional arrangement which is accommodated in the device housing in an operational position and which has at least one control device as functional unit, an input/output device provided on the device housing in an arrangement position; wherein: the input/output device is connected to the control device through an opening in the device housing for signal transmission; the input/output device includes a locking formation, and a locking counter-formation is provided in the interior of the device housing; the locking formation is in a locking form-fitting engagement with the locking counter-formation, which prevents removal of the input/output device from the arranged position thereof in a lifting direction away from the device housing; at least one formation from the locking formation and locking counter-formation is movable out of a release position along a movement path transversely with respect to the lifting direction into a locking position; in the release position there is no locking form-fitting engagement between the locking formation and the locking counter-formation, and in the locking position the locking form-fitting engagement is produced.
The invention relates to a device (20) for determining the feed (V'02) of oxygen into blood in an oxygenator (10), comprising a gas flow sensor (24a, 24b) which is designed to measure a flow (flowsipm. flowsrpout) of an oxygen-containing gas mixture flowing through the oxygenator (10); and a gas sensor unit (26a, 26b; 26, 28, 30) which is designed to measure the oxygen content (p02/n) of the oxygen-containing gas mixture flowing into the oxygenator (10) and the oxygen content (jDoaoui) of a gas mixture flowing out of the oxygenator (10). For this purpose, the device is designed to determine a discrepancy, in particular a difference, between the oxygen content (po2/n) of the oxygen-containing gas mixture flowing into the oxygenator (10) and the oxygen content (Po2oui) of the gas mixture flowing out of the oxygenator (10) and to determine the feed (V'O2) of oxygen into the blood flowing through the oxygenator (10) from the determined difference and the flow (JlowsiPin. flowsrpout) measured by the gas flow sensor (24a, 24b).
The invention relates to a fluid-conducting device (65) for introducing fluid into and/or removing fluid from an oesophageal catheter (48) which can be inserted into an oesophagus (34) and has a balloon probe (46) for determining an oesophageal balloon pressure, comprising: a measuring fluid port (90), which is designed to be coupled to a distal end (48b) of the oesophageal catheter (48) such that, in the coupled state, fluid can be introduced into the oesophageal catheter (48) via the measuring fluid port (90) and/or can be removed from the oesophageal catheter (48); a pump device (100) having at least one fluid pump (102), wherein the pump device (100) is designed to conduct fluid in at least one first conducting direction; and a switching valve (106), which is associated with the at least one fluid pump (102) and can be switched at least between a first position and a second position. The at least one fluid pump (102) is in the form of a micropump or diaphragm pump.
An emergency ventilator for artificially ventilating patients in the event of a medical emergency, including: - a housing with an ambient air suction opening and a ventilating gas outlet opening, - a fan which is designed and is arranged in the housing so as to convey ambient air from the ambient air suction opening to the ventilating gas outlet opening, - an air filter which is designed to purify suctioned ambient air and which is arranged in the housing downstream of the ambient air suction opening in the flow path of the ambient air, and - an energy storage device for supplying the fan with energy in order to operate same, wherein the air filter is received in the housing in an accessible manner through a housing opening, which is closed but can be opened by a housing cover, and so as to be replaceable in an intended manner, and the energy storage device is received in the housing in an accessible manner through the housing opening, which is closed but can be opened by the housing cover, and so as to be replaceable in an intended manner, the air filter and the energy storage device can be accessed through a common housing opening, the common housing opening being selectively closable and openable by a common housing cover.
A ventilation device for artificial ventilation, having: —a ventilation gas source; —a ventilation conducting assembly for conducting inspiratory ventilation gas from the ventilation gas source to a patient-side, proximal ventilation-gas outlet opening and for conducting expiratory ventilation gas away from a proximal ventilation-gas inlet opening; —a pressure-changing assembly for changing the pressure of the ventilation gas flowing in the ventilation conducting assembly; —a control device, which is designed to control the operation of the ventilation gas source and/or the operation of the pressure-changing assembly; —an evaluation device for processing sensor signals; and —an O2 sensor assembly for determining an O2 concentration value representing the oxygen concentration of the ventilation gas flowing in the ventilation conducting assembly, wherein the O2 sensor assembly outputs O2 sensor signals, which contain information regarding the O2 concentration value, to the evaluation device, and wherein the evaluation device is designed to determine, on the basis of the O2 sensor signals, an O2 change value representing a change in the O2 concentration value and, if the O2 change value satisfies a predefined condition, to infer degradation of the O2 sensor assembly and to output a signal.
The invention relates to a method for separating HMW DNA and/or UHMW DNA from a carrier element (8), to which the DNA is removeably attached, using a centrifugation container set (2) with at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and at least one collection vessel 40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) is removeably attached to the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) has a container wall (14) surrounding a container interior (12) and a container base (16) with at least one out-flow opening (20), wherein the out-flow opening (20) forms at least one flow path (24) for a fluid to be centrifugated from the container interior (12) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel interior (42) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h), wherein the at least one centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) and the at least one collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) are geometrically coordinated with one another in such a way that there is a clear distance (a) from an outlet opening (22) of the out-flow opening (20) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h) to a vessel base (44) of the collection vessel (40a, 40b, 40c, 40d, 40e, 40f, 40g, 40h) in the direction of a main extension axis (H1) of the centrifugation container (10a, 10b, 10c, 10d, 10e, 10f, 10g, 10h), wherein the clear distance (a) is selected in such a way that any strands of the DNA are separated from the outlet opening (22).
A pipetting device for outputting amounts of a dosing fluid of less than 1 μl including a fluid volume; a pipetting plunger that can be moved along a plunger path, wherein a displacement of the pipetting plunger brings about a first pressure change in the fluid volume; a movement drive which is force-transmittingly connected to the pipetting plunger in order to drive the pipetting plunger such that it moves along the plunger path; a sound source which is designed to generate at least one sound impulse as a second pressure change in the fluid volume; and a control device which is designed to control the movement drive and the sound source, the pipetting device having a pipetting channel which extends along a channel axis and in which both the pipetting plunger is moveably accommodated along the channel axis as the plunger path and the fluid volume is accommodated, wherein the fluid volume includes a working gas which wets a plunger surface of the pipetting plunger, wherein, in addition, the sound source is designed and arranged to generate the at least one sound impulse in the working gas.
A float-controlled valve array including a valve assembly having a conduit, a valve seat formation through which the conduit passes, and a valve body formation which is movable between a closed position in which the conduit is closed and an open position in which a flow through the conduit is possible; the valve array further including a first and a second float body having a first and a second buoyancy volume portion, respectively, wherein the first and the second float bodies are articulated pivotally on a first and a second joint, respectively, so that during specified normal operation, each float body is movable along a buoyancy axis between a lowered position and a buoyant position, and wherein the first float body and the second float body are each coupled to the valve body formation in such a way that the valve body formation is in the closed position when at least one of the float bodies is in the buoyant position, and is in the open position when both float bodies are in the lowered position; the buoyancy volume portions of the two float bodies are mutually spaced apart at a distance orthogonal to the buoyancy axis in the lowered position, wherein at least one joint is located in a body spacing region between the two buoyancy volume portions.
A61M 16/16 - Devices to humidify the respiration air
52.
PIPETTING UNIT WITH CAPACITIVE LIQUID DETECTION, COMBINATION OF SUCH A PIPETTING UNIT AND A PIPETTING TIP, AND METHOD FOR CAPACITIVELY DETECTING PIPETTING LIQUID
A pipetting unit (2) with capacitive liquid detection comprises: a pressure tube (10); a shield (12) disposed around the pressure tube (10); a coupling (14) for temporarily attaching a pipetting tip (4) to the pipetting unit (2), wherein when the pipetting tip (4) is connected, an electrical connection is established between the pressure tube (10) and the pipetting tip (4); and an electric circuit (20) coupled to the pressure tube (10) and the shield (12), wherein the electric circuit (20) is configured to apply a time-variable electrical signal to the pressure tube (10), said time-variable electrical signal permitting a capacitive detection of a contact between the pipetting tip (4) and a pipetting liquid (112) when the pipetting tip (4) is connected, and wherein the electric circuit (20) is configured to connect the shield (12) to ground.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01F 23/263 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields by measuring variations in capacitance of capacitors
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
53.
METHOD AND DEVICE FOR AUTOMATED CHARACTERISATION OF OESOPHAGEAL CATHETERS HAVING A BALLOON PROBE
esoesoeso) detected in the oesophageal catheter (48); - a memory device (70) for storing at least the property that characterises the oesophageal catheter (48); and - at least one controller (80, 82, 84, 86) for controlling the characterisation system (60), which controller is designed such that the characterisation system (60) carries out a method that comprises at least the following steps: - filling the oesophageal catheter (48) with a measuring fluid ex vivo, in particular prior to positioning the oesophageal catheter (48) in an oesophagus; - detecting a pressure prevailing in the oesophageal catheter (48); - determining at least one property that characterises the oesophageal catheter (48), on the basis of the detected pressure; and - storing at least the property that characterises the oesophageal catheter (48).
A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
54.
DEVICE FOR ADJUSTING A VENTILATION PARAMETER SPECIFIED BY A VENTILATION DEVICE AND/OR FOR AUTOMATICALLY DISPLAYING INFORMATION WHICH IS RELEVANT TO A MECHANICAL VENTILATION ON THE BASIS OF AN ESOPHAGUS BALLOON PRESSURE
The invention relates to a device (15) for automatically adjusting a ventilation parameter (192A, 192B, 192C, 192D), in particular a pressure, in particular a positive end-expiratory pressure (REEP) and/or a maximum airway pressure (Paw_max), which is specified by a ventilation device (10) and/or for automatically displaying information which is relevant to a mechanical ventilation, in particular information on a transpulmonary pressure (Ptp), comprising a pressure ascertaining system (300) for ascertaining a transpulmonary pressure, in particular a transpulmonary pressure (Ptp_ee) at the end of an expiration phase and/or a transpulmonary pressure (Ptp_ei) at the end of an inspiration phase, on the basis of an esophagus balloon catheter (45), which can be introduced into the esophagus (34) and which comprises a balloon probe (46) for determining the esophagus balloon pressure (Peso); an esophagus balloon control system (400) for automatically monitoring and/or adjusting an operational filling process of the balloon probe (46) of the esophagus balloon catheter (45) in vivo; and a ventilation controller (180). The ventilation controller (180) is designed to adjust the ventilation parameter (192A, 192B, 192C, 192D) specified by the ventilation device (10) and/or to display the information which is relevant to the mechanical ventilation on the basis of the transpulmonary pressure (Ptp) ascertained by the pressure ascertaining system (300). The ventilation controller (180) is also designed to automatically actuate the esophagus balloon control system (400), and/or the esophagus balloon control system (400) is also designed to automatically actuate the ventilation controller (180).
The present invention relates to a turbidity sensor (10) for detecting clouding of a fluid by particulates contained in the fluid, wherein the turbidity sensor (10) comprises: - a fluid detection region (14) for the reception and metrological detection of fluid; - a radiation source (54) for emitting radiation into the fluid detection region (14); - a first radiation sensor (32) for detecting a first part of the radiation emitted by the radiation source (54); and - a second radiation sensor (62), different from the first radiation sensor (32), for detecting a second part of the radiation emitted by the radiation source (54) that is different from the first part, wherein at least a portion of the fluid detection region (14) is located between the first radiation sensor (32) and the second radiation sensor (62). According to the invention, the second radiation sensor (62) is located in the beam path (OA) of the first part of the radiation emitted by the radiation source (54) that is detected by the first radiation sensor (32).
The present invention relates to a wall holder (12) for an emergency ventilator arrangement (14), comprising a basic structure (30) which can be attached to a substantially flat wall and is designed for releasably receiving the emergency ventilator arrangement (14), wherein the basic structure (38) has a receiving side (38a), which is provided with receiving means (42, 66) for releasably receiving the emergency ventilator arrangement (14), and an installation side (38b) which is opposite the receiving side (38a) and, in a state attached to the wall and ready for operation, faces the wall, wherein the installation side (38b) defines a reference surface (BE) designed for contact with the wall, wherein the receiving means (42, 66) comprise: - a hanging structure (66) permitting hanging of a hanging counter structure (68), and - a locking device (42) which is arranged at a distance along the reference surface (BE) from the hanging structure (66), wherein the locking device (42) has a locking structure (48) which is accommodated on the basic structure (38) so as to be shiftable between an engagement preparation position and an engagement position, wherein, in the engagement position, the locking structure (48) is designed to secure a locking counter structure (34) of the emergency ventilator arrangement (14) in a form-fitting manner. According to the invention, it is provided that the engagement preparation position differs from the engagement position.
F16M 13/02 - Other supports for positioning apparatus or articlesMeans for steadying hand-held apparatus or articles for supporting on, or attaching to, an object, e.g. tree, gate, window-frame, cycle
58.
CONNECTION COMPONENT FOR A TRACHEAL CANNULA, IN PARTICULAR FOR PROTECTING AGAINST AN UNINTENTIONAL CLOSURE OF SAME
An attachment for a tracheal cannula, the attachment surrounding a cavity, the attachment being open both in a coupling area of the attachment as well as in an orifice area of the attachment, differing in location from the coupling area, for providing an access to the cavity, the attachment having in the coupling area a latching formation, which is designed for the releasable connection to a mating latching formation of the tracheal cannula, the coupling area surrounding a section of the cavity, the section of the cavity surrounded by the coupling area being centrally penetrated by a virtual coupling axis, the coupling axis defining an axial direction along its path, defining a plurality of radial directions orthogonally to its path and defining a circumferential direction running around it, the coupling area having at least one support section, on which the latching formation and a force application area are situated in such a way that by exerting an actuating force on the force application area in the radial direction toward the coupling axis, the support section is displaceable between two positions of different radial distance of the latching formation situated on the support section from the coupling axis; the force application area and the latching formation displaceable by an exertion of force on the force application area of the same support section are situated along the coupling axis at an axial distance from each other.
A portable respiratory device for supplying respiratory gas to a living being, including: a housing; a respiratory gas conveying apparatus which is designed to convey inspiratory respiratory gas to a respiratory gas housing outlet of the housing; an input/output apparatus for the input of control commands and for the output of information; a control apparatus which is connected to the input/output apparatus and to the respiratory gas conveying apparatus for transferring signals; a first, grid-based power supply which is designed to be connected to a grid voltage source that is external in respect of the respirator device in order to transfer electricity and which is designed and arranged in order to supply electricity to the control apparatus, the input/output apparatus and the respiratory gas conveying apparatus; wherein the respiratory gas conveying apparatus, the input/output apparatus, the control apparatus and the first power supply are received in the housing; the respiratory device has a second, storage-based power supply which has an electricity storage device for storing electrical energy and which is designed at least to supply the respiratory gas conveying apparatus with electricity.
The present invention relates to an expiration valve assembly (16) for a ventilator, comprising - an expiration channel (38) which has, at one end, an expiration outlet (22) and an inlet connection part (30a) that is designed to connect to an expiration breathing gas line (36a) and which, at its other end, has an expiration outlet (40), the expiration channel (38) having an expiration valve (42), - an inspiration channel (52) which has, at one end, an inspiration inlet (54) and an inlet connecting part (58) that is designed to connect to a breathing gas source supplying inspiratory breathing gas, and which, at its other end, has an inspiration outlet (24) and an outlet connecting part (30b) that is designed to connect to an inspiration breathing gas line (36b), - a control channel (68) which branches off from the inspiration channel (52) at a branch location (66) and leads to the expiration valve (42) in such a way that the expiration valve (42) can be loaded by inspiratory breathing gas into a blocking position which blocks the flow of expiratory breathing gas, characterised in that a one-way valve (60, 60') is arranged in the inspiration channel (52) and permits a flow of inspiratory breathing gas in the inspiration direction (I) from the inspiration inlet (54) to the inspiration outlet (24) and prevents a flow of breathing gas in the opposite direction.
A61M 16/20 - Valves specially adapted to medical respiratory devices
61.
METHOD FOR CARRYING OUT A P/V MANEUVER WHICH AUTOMATICALLY PREVENTS AN OVERDILATION OF THE LUNGS, AND VENTILATION DEVICE DESIGNED TO CARRY OUT THE METHOD
A ventilation device for artificially ventilating a patient, the controller of the ventilation device being designed to actuate a flow modifying device for carrying out a P/V maneuver, in which a patient is supplied with respiratory gas while the pressure of the respiratory gas is increased during an inspiration phase, said respiratory gas passively flowing out of the patient during an expiration phase after the pressure increase is terminated. For a plurality of respiratory gas pressures, the respective maneuver respiratory gas volume present in the patient as a result of the P/V maneuver is ascertained in connection with the present respiratory gas pressure during the inspiration phase as well as during the expiration phase; the controller is designed to—ascertaining a sequence of lung compliance values during the inspiration phase on the basis of signals of a flow sensor assembly and a pressure sensor assembly, —ascertain a reference compliance value in accordance with the sequence of compliance values, —on the basis of the reference compliance value, determine a termination compliance value, which differs from the reference compliance value in terms of amount, in the form of a threshold value as a termination criterion for the inspiration phase, and —terminate the inspiration phase if the termination compliance value is reached or exceeded.
The present application relates to a pipetting device and a pipetting method for pipetting, therefore for aspirating and/or dispensing, a metered liquid using a working gas, independently of the flow- and/or wetting characteristics of the metered liquid, wherein a pipetting channel comprises a first working region, of which the known base temperature is in a lower base temperature range, and a second working region, of which the known working temperature is in a working temperature range that is increased with respect to the base temperature range.
A multi-channel infrared gas sensor including a beam splitter arrangement, which splits an infrared beam into four infrared partial beams, four bandpass filters and four infrared sensors, respectively one for each infrared partial beam at a first used signal wavelength. The directions of propagation of the four infrared partial beams differ from one another in pairwise fashion. A first and second infrared used signal sensor are arranged so that respective used signal sensor detection areas have a symmetric orientation with respect to a used signal sensor plane of symmetry situated between the detection areas. A first and second infrared reference signal sensor are arranged so that respective reference signal sensor detection areas have a symmetric orientation with respect to a reference signal sensor plane of symmetry situated between the reference signal sensor detection areas. No signal sensor detection area is orthogonal to its respective signal sensor plane of symmetry.
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
64.
MODULAR SWITCHING-VALVE ASSEMBLY FOR A RESPIRATORY DEVICE
The present invention relates to a switching-valve assembly (10), which comprises: - a housing (12), having a first source port (26), a second source port (54) and an outlet port (18); - a first gas-supply line (60), which connects the first source port (26) to the outlet port (18); - a second gas-supply line (64), which connects the second source port (54) to the outlet port (18); - a valve arrangement (40, 42, 74, 76), which is accommodated in the housing (12) and can be adjusted between a first operating state, in which it opens the first gas-supply line (60) to allow respiratory gas to flow through and blocks the second gas-supply line (64), and a second operating state, in which it blocks the first gas-supply line (60) and opens the second gas-supply line (64) to allow respiratory gas to flow through. According to the invention, the switching-valve assembly (10) in the form of a modular switching-valve assembly (10) is designed to be stackable, by the housing (12) having a first outer-surface portion (24) for stacking and a second outer-surface portion (16) for stacking, which is designed to as to be complementary to the first outer-surface portion (24) for stacking, wherein a source port (26) is designed as a sequence port (26) such that, when the first and the second outer-surface portions (16, 24) for stacking are considered in stacked engagement with one another, proceeding from the outlet- and the sequence port (18, 26), gas-supply line portions (20, 28) extending into the housing (12) are each connected to a continuous gas-supply line region (30).
A measurement cuvette for detecting at least one fluid constituent of a fluid flowing through the measurement cuvette by means of electromagnetic radiation, includes: a channel, which extends through the measurement cuvette along a channel path extending centrally through the channel; a coupling and detection portion, which extends, between its first longitudinal end and its second longitudinal end, along a linear longitudinal axis, detachably mechanically coupled to a radiation component; a physical orientation structure, which allows detachable mechanical coupling of the measurement cuvette to the radiation component in a predefined desired relative orientation and prevents the detachable mechanical coupling in an undesired relative orientation. The physical orientation structure is arranged and formed between the first and the second longitudinal ends of the coupling and detection portion.
The invention relates to a calibration system (60) for automatically setting an intended operational filling of an esophagus catheter (48) with a balloon probe (46) for the purposes of determining an esophageal pressure (Peso), the esophagus catheter being insertable into the esophagus (34) and serving in particular for a ventilation apparatus (10), the calibration system comprising an arrangement for filling the balloon probe (46) with a measuring fluid after placing the balloon probe (46) into the esophagus (34), a pressure sensor for detecting the esophageal pressure (Peso) prevalent in the balloon probe (46), and a calibration controller (60) designed such that it incrementally changes the amount of measuring fluid in the balloon probe (46), the calibration controller (60) recording an esophageal pressure (Peso) detected by the pressure sensor for each amount of measuring fluid in the balloon probe (46) set incrementally as a measuring point in this way and assigning the esophageal pressure to the respective set amount of measuring fluid in the balloon probe (46). The calibration controller (60) is designed such that it monotonically changes the amount of measuring fluid in at least two steps to reach an end value starting from a start value, for the purposes of homing in on the respective measuring points.
The invention relates to a measurement device for determining at least one gas component of a gas present in a measuring chamber of the measuring device, the measuring device comprising a housing enclosing the measuring chamber, at least one housing wall section of which housing being designed as an observation section for detecting electromagnetic radiation emanating from the observation section in a direction away from the measuring chamber, the observation section comprising at least one film layer, and the housing being designed as a plastic injection-moulded housing. The invention is characterised in that the observation section has at least one observation wall component comprising an injection-moulded observation body injection-moulded onto the at least one film layer, and the housing comprises the at least one observation wall component and an injection-moulded frame body injection-moulded onto the observation wall component.
A sensor arrangement includes a reaction subassembly having a housing and a detector subassembly. The housing is a layered component arrangement encompassing a luminophore-containing reaction laminate excitable, by irradiation with a first electromagnetic radiation of a first wavelength, to emit a second electromagnetic radiation of a second wavelength different from the first wavelength; and a temperature-detection laminate emitting an infrared radiation. The housing includes an opening for introducing a fluid, a reaction window and a temperature-sensing window. The reaction window transmits the first and second electromagnetic radiation, and the temperature-sensing window is penetrable by infrared radiation. The detector subassembly encompasses a radiation source emitting the first electromagnetic radiation, a radiation detector detecting the second electromagnetic radiation, and an infrared detector detecting, through the temperature detection window, the infrared radiation emitted from the temperature detection laminate. The reaction laminate and the temperature-detection laminate are embodied separately.
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
G01J 5/00 - Radiation pyrometry, e.g. infrared or optical thermometry
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
69.
NON-DISPERSIVE MULTI-CHANNEL SENSOR ASSEMBLY HAVING REFRACTIVE AND/OR DIFFRACTIVE BEAMSPLITTER
A non-dispersive multi-channel radiation sensor assembly includes a beamsplitter assembly, a first band-pass filter, which has a predefined first bandwidth and has a transmission maximum at a predefined first useful-signal wavelength, a first measurement-radiation useful-signal sensor, which is arranged downstream of the first band-pass filter in the beam path, a second band-pass filter, which has a transmission maximum at a predefined first reference-signal wavelength, a first measurement-radiation reference-signal sensor, which is arranged downstream of the second band-pass filter in the beam path. The beamsplitter assembly has a first irradiation region and a second irradiation region, in which irradiation regions the beamsplitter assembly is irradiated with measurement radiation. The irradiation regions are optically designed in such a way that the beamsplitter assembly deflects, in the first irradiation region, a first part of the measurement radiation onto the first band-pass filter and a second part of the measurement radiation onto the second band-pass filter.
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
G01N 21/3504 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
70.
METHOD FOR DETERMINING THE FUNCTIONAL RESIDUAL CAPACITY OF A PATIENT'S LUNG AND VENTILATOR FOR CARRYING OUT THE METHOD
A method for determining the functional residual capacity of a patient's lung, includes supplying a first inspiratory breathing gas having a first proportion of a metabolically inert gas, supplying a second inspiratory breathing gas having a second proportion of the metabolically inert gas, determining any arising volume difference, which represents a difference in volume between a volume of inspiratory and of expiratory metabolically inert gas for a determination period, determining the functional residual capacity taking into account the volume difference and a proportion difference between a first proportion quantity and a second proportion quantity, which represent the first proportion and the second proportion of the metabolically inert gas, respectively, and determining a base difference, which represents a difference between a tidal volume of inspiratory metabolically inert gas and of expiratory metabolically inert gas.
The present invention relates to a method for determining a respiratory-gas content in a respiratory tract, which content is present in the respiratory tract of an at least partially artificially ventilated patient following a plurality of breaths performed with the involvement of a ventilation apparatus, wherein the plurality of breaths include at least one earlier number of breaths and at least one follow-up breath following the earlier number of breaths; wherein the earlier number of breaths include an earlier breath or a plurality of successive earlier breaths; wherein the method comprises quantitative detection of inspiratory and expiratory respiratory-gas flows (S10) by at least one respiratory-gas flow sensor and summation of detected inspiratory and expiratory flow values to form the respiratory-gas content (S110) in the respiratory tract; wherein a respiratory tract content starting value, at which the determination of the respiratory-gas content in the respiratory tract for the follow-up breath starts, depending on a difference in respiratory-gas amount between an inspiratory respiratory-gas amount supplied to the patient during an earlier number of breaths and an expiratory respiratory-gas amount output by the patient during the earlier number of breaths, is set to a reset starting value (S140), which is closer to zero than to a difference value that quantitatively provides the respiratory-gas amount difference, or is set to a continuity starting value (S100), which is closer to the difference value than to zero.
The invention relates to a patient treatment gas supply system having a nasal cannula having a cannula connection and a treatment gas outlet opening; a treatment gas supply line having a line connection which is designed to form a detachable treatment-gas-carrying connection in a connection region with the cannula connection, wherein the cannula connection and the line connection overlap along a flow path formed via the connection region; and a blocking assembly which can be moved between a blocking position and a release position, wherein a force necessary for releasing the connection between the cannula connection and the line connection is greater when the blocking assembly is in the blocking position than when the blocking assembly is in the release position.
The present invention relates to a spectroscopic sensor assembly (10) for detecting at least one predefined analyte constituent of a measurement fluid, the sensor assembly (10) comprising: - a sensor housing (12); - a radiation source (64); - a detector device (66); - a barrier assembly (28), which is transmissive for measurement radiation and is impermeable to the analyte constituent; - a polymer matrix (40), which absorbs and releases the analyte constituent; - a reflector assembly (36, 136), which has a signal side (36b; 136b) facing the polymer matrix (40) and facing the barrier assembly (28); wherein the reflector assembly (36; 136) has at least one passage (54; 154) extending through the reflector assembly, through which passage the analyte constituent is exchanged between a measurement environment (M) and the polymer matrix (40), which polymer matrix is located on the signal side (36b; 136b) of the reflector assembly (10); and wherein the reflector assembly (10) reflects incident measurement radiation back toward the apparatus portion (18). According to the invention, the sensor assembly (10) has a spacing means (48) different from the polymer matrix (40), the spacing means being designed to prevent the reflector assembly (36; 136) from approaching the barrier assembly (28).
G01N 21/85 - Investigating moving fluids or granular solids
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
74.
METHOD AND SENSOR FOR DETERMINING A VALUE INDICATING THE IMPEDANCE OF A SUSPENSION
A method for determining a value indicative of the impedance of a suspension in the framework of impedance spectroscopy comprises the following steps: generating an excitation current through the suspension, oscillating at an excitation frequency; determining a first impedance measurement value on the basis of the excitation current and a first voltage at a first pair of measurement electrodes; determining a second impedance measurement value on the basis of the excitation current and a second voltage at a second pair of measurement electrodes; determining the value indicative of the impedance of the suspension by correlating the first impedance measurement and the second impedance measurement.
The present invention relates to a ventilator device (10) for at least supporting artificial ventilation of patients, comprising: • - a device housing (12), • - a functional arrangement (34) received in the device housing (12), the functional arrangement (34) comprising, as functional units, at least one portion of a breathing gas line (38, 60), a pressure-changing device (36) for changing a breathing gas pressure in the breathing gas line (38, 60), and a control device (28) for controlling the operation of at least one pressure-changing device (36), and - an input/output device (18), which is arranged on the device housing (12), is accessible from outside the device housing (12) in order to be operated, and is intended for inputting data and/or control commands at the control device (28) and/or for outputting data and information, the input/output device (18) being connected to the control device (28) for signal transmission. In accordance with the invention, the ventilator device (10) has a frame (42), the device housing (12) with the input/output device (18) arranged thereon being received on the frame (42) so as to be rotatable about a virtual rotation axis (D).
The present invention relates to a ventilator device (10) for at least supporting artificial ventilation of patients, comprising: - a device housing (12), - a functional arrangement (60) which is accommodated in the device housing (12) in an operational position and which has at least one control device (62) as functional unit, and - an input/output device (40) provided on the device housing (12) in an arrangement position; wherein: the input/output device (40) is connected to the control device (62) through an opening (14g) in the device housing (12) for signal transmission; the input/output device (40) comprises a locking formation (76), and a locking counter-formation (66) is provided in the interior of the device housing (12); the locking formation (76) is in a locking form-fitting engagement with the locking counter-formation (66), which prevents removal of the input/output device (40) from the arranged position thereof in a lifting direction (A) away from the device housing (12); at least one formation (66) from the locking formation (76) and locking counter-formation (66) is movable out of a release position along a movement path (B) transversely with respect to the lifting direction (A) into a locking position; in the release position there is no locking form-fitting engagement between the locking formation (76) and the locking counter-formation (66), and in the locking position the locking form-fitting engagement is produced.
The invention relates to a ventilation device (10) for an at least supportive artificial ventilation of patients, comprising: a device housing (12), a functional assembly (60), which is received in the device housing (12) in an operational position and which has at least one controller (62) as a functional unit, and an input/output device (40) which is arranged on the device housing (12) in an assembly position. The input/output device (40) is connected to the controller (62) through an opening (14g) in the device housing (12) so as to transmit signals, and the input/output device (40) is secured directly to the functional assembly (60) so as to prevent removal of the input/output device (40) from its assembly position away from the device housing (12) in a lifting direction (A).
A liquid-metering device for discharging metered liquid in the nanometer range, includes a pipetting-tip receiving device defining, at least in a metering-ready operating position of the liquid-metering device, a receiving space that runs along a virtual receiving axis and is designed to receive a portion of a pipetting-tip. The liquid-metering device also includes a triggering plunger moveable relative to the pipetting-tip receiving device, between a standby position and a triggering position. The liquid-metering device also includes movement drive, which is coupled to the triggering plunger so as to transmit motion, and a control device for controlling operation of the movement drive. A first and second deformation formation define therebetween an axial longitudinal region of the receiving space as a deformation region, in which region the first and second formations can be brought closer or farther away to/from one another. The triggering plunger is located in the deformation region.
The invention relates to an emergency ventilator (10) for artificially ventilating patients in the event of a medical emergency, comprising: - a housing (12) with an ambient air suction opening (40) and a ventilating gas outlet opening (76), - a fan which is designed and is arranged in the housing (24) so as to convey ambient air from the ambient air suction opening (40) to the ventilating gas outlet opening (76), - an air filter (29) which is designed to purify suctioned ambient air and which is arranged in the housing (12) downstream of the ambient air suction opening (40) in the flow path of the ambient air, and - an energy storage device (34) for supplying the fan with energy in order to operate same, wherein the air filter (29) is received in the housing (12) in an accessible manner through a housing opening (24), which is closed but can be opened by a housing cover (22), and so as to be replaceable in an intended manner, and the energy storage device (34) is received in the housing (12) in an accessible manner through the housing opening (24), which is closed but can be opened by the housing cover (22), and so as to be replaceable in an intended manner. The invention is characterized in that the air filter (29) and the energy storage device (34) can be accessed through a common housing opening (24), said common housing opening (24) being selectively closable and openable by a common housing cover (22).
The invention relates to an emergency ventilator (10) for artificially ventilating patients in the event of a medical emergency, comprising: - a housing (12) with an ambient air suction opening (40) and a ventilating gas outlet opening (76) and - a fan (42) which is designed and is arranged in the housing (12) so as to convey ambient air from the ambient air suction opening (40) to the ventilating gas outlet opening (76), wherein the fan (42) comprises a fan housing (42a) with an air conveyor (42b) which can be moved relative to the fan housing (42a), and the fan housing (42a) is arranged in the housing (12) in a fixed manner thereto. According to the invention, the fan housing (42a) is secured to the housing (12) with the interposition of a heat conducting body (94), said heat conducting body (94) comprising or being made of a material which is selected from light metal, nonferrous metal, and/or a plastic filled with a heat-conductive filler material.
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
F04D 25/08 - Units comprising pumps and their driving means the working fluid being air, e.g. for ventilation
H02K 9/22 - Arrangements for cooling or ventilating by solid heat conducting material embedded in, or arranged in contact with, the stator or rotor, e.g. heat bridges
81.
PIPETTING DEVICE WITH GAS-SOUND-TRIGGERED DISPENSING OF FLUID AMOUNTS PREFERABLY IN THE RANGE OF 10 TO 500 NL
The invention relates to a pipetting device (10) for outputting amounts of a dosing fluid (32) of less than 1 µl, comprising: a fluid volume (39); a pipetting plunger (14) that can be moved along a plunger path, wherein a displacement of the pipetting plunger (14) brings about a first pressure change in the fluid volume (39); a movement drive (22) which is force-transmittingly connected to the pipetting plunger (14) in order to drive the pipetting plunger (14) such that it moves along the plunger path; a sound source (42) which is designed to generate at least one sound impulse as a second pressure change in the fluid volume (39); and a control device (24) which is designed to control the movement drive (22) and the sound source (42). According to the invention, the pipetting device (10) comprises a pipetting channel (11) which extends along a channel axis (K) and in which both the pipetting plunger (14) is moveably accommodated along the channel axis (K) as the plunger path and the fluid volume (39) is accommodated, wherein the fluid volume (39) comprises a working gas (34) which wets a plunger surface (14a) of the pipetting plunger (14), wherein, in addition, the sound source (42) is designed and arranged to generate the at least one sound impulse in the working gas (34).
The present invention relates to a float-controlled valve array (42) comprising a valve assembly (43) having a conduit (40), a valve seat formation (48) through which the conduit passes, and a valve body formation (50) which is movable between a closed position in which the conduit (40) is closed and an open position in which a flow through the conduit (40) is possible. The valve array (42) further comprises: a first and a second float body (52, 54) having a first and a second buoyancy volume portion (52a, 54a), respectively, wherein the first and the second float bodies (52, 54) are articulated pivotally on a first and a second joint (56, 58), respectively, so that during specified normal operation, each float body (52, 54) is movable along a buoyancy axis (A) between a lowered position and a buoyant position, and wherein the first float body (52) and the second float body (54) are each coupled to the valve body formation (50) in such a way that the valve body formation (50) is in the closed position when at least one of the float bodies (52, 54) is in the buoyant position, and is in the open position when both float bodies (52, 54) are in the lowered position. According to the invention, the buoyancy volume portions (52a, 54a) of the two float bodies (52, 54) are mutually spaced apart at a distance (a) orthogonal to the buoyancy axis (A) in the lowered position, wherein at least one joint (56, 58) is located in a body spacing region (67) between the two buoyancy volume portions (52a, 54a).
G01F 23/00 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
A61M 16/16 - Devices to humidify the respiration air
F24F 6/02 - Air-humidification by evaporation of water in the air
G01F 23/32 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by floats using rotatable arms or other pivotable transmission elements
A nasal cannula includes a distribution conduit running along a virtual distribution path. The distribution path defines a longitudinal direction and has two branch openings. A respective supply conduit branches off from each branch opening. The distribution conduit also has two coupling openings arranged spaced apart from the branch openings. The nasal cannula has a plug via which one of the two coupling openings can be sealed as a closure opening. Another of the two coupling openings is designed as a supply opening. The plug has a flow-directing configuration with an exposed flow-directing surface. In a reference state in which the plug is closing the closure opening, the flow-directing surface is arranged in the distribution conduit in the longitudinal extension region of at least one branch opening and positioned relative to the distribution path to deflect treatment gas flowing in the distribution conduit from the supply opening along the distribution path towards at least one of the branch openings.
a valve subassembly (63) which comprises a valve body (64) and a valve seat (66) and which is provided between the upstream and the downstream respiratory gas conduit (54, 58) in such a way that, in the context of a predetermined first respiratory gas overpressure in the upstream respiratory gas conduit (54) relative to the downstream respiratory gas conduit (58), it permits an expiratory respiratory gas flow from the upstream respiratory gas conduit (54) into the downstream respiratory gas conduit (58); and in the context of a predetermined second respiratory gas overpressure in the downstream respiratory gas conduit (58) relative to the upstream respiratory gas conduit (54), it blocks a gas flow from the downstream respiratory gas conduit (58) into the upstream respiratory gas conduit (54).
Provision is made according to the present invention that the exhalation valve arrangement (22) comprises a bypass chamber (74) which communicates in terms of flow mechanics with the upstream respiratory gas conduit (54) and which extends, proceeding from the upstream respiratory gas conduit (54), into the region of the downstream respiratory gas conduit (58) and is embodied there for attachment of a gas pressure sensor (80).
The invention relates to a respiratory device (10) for the artificial respiration of a patient (12), comprising:—a respiration gas source assembly (15, 62),—a flow-changing device (16),—a humidifier device (38) which is designed to increase the value of the absolute humidity of the inspiratory respiration gas flow (AF), said humidifier device (38) having a liquid store (40) and an evaporation device (76) with a variable output for this purpose,—a respiration gas line assembly (30) in order to convey the inspiratory respiration gas flow (AF) from the dehumidifying device (38) to the patient (12),—a flow sensor (44) which detects the value of the respiration gas flow (AF), and—a controller (18) which is designed to control the operational output of the evaporation device (76) depending on a specified target humidity of the respiration gas and depending on signals of the flow sensor (44), the proximal end (30a) of said respiration gas line assembly (30) having a coupling formation (44a) for coupling the respiration gas line assembly (30) to a patient interface (31) that transfers respiration gas to the patient (12). According to the invention, the controller (18) is designed to detect a sequence state of the respiration situation downstream of the coupling formation (44a) in the inspiratory direction depending on operational parameters of the respiratory device (10) and change the operational output of the evaporation device (76) depending on the result of the detection
A pipette device comprises a pipette channel filled with compressible working gas, a pipette piston movable along the pipette path, a piston drive, which drives the pipette piston, a control device, a data memory connected to the control device for signal transmission, a pressure sensor which detects the pressure of the working gas and which is connected to the control device, a position sensor which detects a position of the pipette piston and which is connected to the control device. The control device is designed to determine a quality of a dispensing sequence on the basis of a target residual quantity value, which represents the target residual quantity of dosing liquid remaining in the pipette channel, of a working gas pressure and of an end position of the pipette piston, in each case after the end of the dispensing sequence, and to output the determined quality.
A pH combination electrode includes inner and outer tubes, working and reference electrodes, and a hydrogel diaphragm between the tubes. A seal is disposed inside the inner tube closer to a first inner tube end than to the second inner tube end. An extended reference chamber is formed inside the inner tube between the seal and the second inner tube end. A first conductive fluid is contained in the inner tube between the seal and the first inner tube end. A second conductive fluid is contained in the extended reference chamber and in a reference chamber formed between the inner and outer tubes. A through-hole in the inner tube allows the second conductive fluid to flow between the reference chamber and the extended reference chamber. The working electrode extends into the inner tube, through the seal and into the first conductive fluid. The reference electrode contacts the second conductive fluid.
A combination electrode includes a working electrode, a reference electrode, a hydrogel diaphragm, an outer tube and an inner tube. The working electrode is disposed in the inner tube. The reference electrode is disposed in a reference chamber formed between the inner tube and the outer tube. The hydrogel diaphragm seals the opening between an end of the outer tube and the inner tube when the hydrogel swells upon coming in contact with a first electrically conductive fluid that is introduced into the reference chamber. The diaphragm is coupled to the reference electrode in an electrically conductive manner through the first electrically conductive fluid, which contacts both the reference electrode and the diaphragm. The inner tube is closed by a glass membrane that is coupled to the working electrode in an electrically conductive manner through a second electrically conductive fluid that contacts both the glass membrane and the working electrode.
The invention relates to a sensor holder (10) for a sensor assembly (82), wherein the sensor holder (10) has a tube section (12) with an outer thread (22) formed thereon, wherein, as a securing thread (22), the outer thread (22) has a securing/releasing formation (60a, 60, b, 60c) in at least one peripheral section of a thread groove (22a), wherein the securing/releasing formation (60a, 60, b, 60c), wherein the securing/releasing formation (60a, 60, b, 60c) reduces the cross-sectional area (Q) of the thread groove (22a) in relation to a peripheral section of the thread groove (22a) that is free of the securing/releasing formation (60a, 60, b, 60c), wherein a material weakening (48) is formed in a region of weakness (46) of the sensor holder (10), wherein the region of weakness (46) includes the entire outer thread (22) and extends beyond the outer thread (22) by at least double the thread pitch of the outer thread (22) and axially in relation to a screw axis (S) of the outer thread (22) on both sides of the outer thread (22), wherein a direction of the material weakening (48), in which the material weakening (48) has its largest measurement, has an axial component (48a) and/or a component (48b) in the peripheral direction in relation to the screw axis (S) of the outer thread (22), wherein the at least one securing/releasing formation (60a, 60, b, 60c) is arranged in the axial extension region of the material weakening (48) and/or is arranged in the peripheral extension region of the material weakening (48).
The present invention relates to a method for assigning a pipette tip (26) to a certain class of pipette tips (26) from a plurality of different pipette tip classes, the method comprising the following steps: coupling the pipette tip (26) to a gas displacement device (12/14) such that a device-side volume (11a, 11b) formed in the gas displacement device (12, 14) and a tip-side volume (11c) formed by the pipette tip (26) communicate with each other, and thereby forming a measuring volume (40) comprising the communicating volumes of the device-side volume (11a, 11b) and the tip-side volume (11c); operating the gas displacement device (12, 14) and thereby changing the gas pressure in the measuring volume (40); detecting the gas pressure in the measuring volume (40) over a detection time period; determining at least one absolute value of at least one characteristic variable characterising the detected gas pressure; comparing the at least one determined absolute value with at least one predetermined calibration value; and, depending on the comparison result, assigning the pipette tip (26) to a pipette tip class and outputting an item of class assignment information representing the assigned pipette tip class.
A method is provided for degradation-compensated evaluation of detection signals of a sensor arrangement operating on the principle of luminescence quenching, which arrangement has a luminophore that degrades over time, an excitation radiation source, and at least one optical sensor. The luminophore radiates, in accordance with a response characteristic of the sensor arrangement, in reaction to irradiation with a predefined modulated excitation radiation and as a function of the extent of an interaction of the luminophore with a quencher substance that quenches the luminescence of the luminophore. A response radiation is detected by the at least one optical sensor. The sensor arrangement outputs a detected intensity value representing an intensity of the response radiation and a detected phase value representing a phase difference of the response radiation with respect to the modulation of the excitation radiation. A predetermined calibration value correlation is identified in consideration of the reference response characteristic.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/85 - Investigating moving fluids or granular solids
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
According to the invention, a laboratory system (100) for the automated measurement of the transmission of samples (17) comprises a support housing, a sample container (7) for receiving the samples (17) and a transport device (120) for transporting the sample container (7) in the support housing. The invention is characterised in that the laboratory system (100) further has a measuring device (9) for examining at least one sample (17) in the sample container (7) using an illumination device (20) and a detection device (30), the transport device (120) being configured to transport the measuring device (9) and the measuring device (9) being designed in two pieces such that the illumination device (20) and the detection device (30) can be separated and assembled by means of the transport device.
G01N 21/25 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
94.
PORTABLE RESPIRATORY DEVICE HAVING POWER SUPPLY VIA POWER GRID AND ELECTRICITY STORE
The present invention relates to a portable respiratory device (10) for supplying respiratory gas to a living being, comprising: a housing (12); a respiratory gas conveying apparatus (13) which is designed to convey inspiratory respiratory gas to a respiratory gas housing outlet (20) of the housing (12); an input/output apparatus (18) for the input of control commands and for the output of information; a control apparatus (16) which is connected to the input/output apparatus (18) and to the respiratory gas conveying apparatus (13) for transferring signals; a first, grid-based power supply (14) which is designed to be connected to a grid voltage source that is external in respect of the respirator device (10) in order to transfer electricity and which is designed and arranged in order to supply electricity to the control apparatus (16), the input/output apparatus (18) and the respiratory gas conveying apparatus (13); wherein the respiratory gas conveying apparatus (13), the input/output apparatus (18), the control apparatus (16) and the first power supply (14) are received in the housing (12). According to the invention, the respiratory device (10) has a second, store-based power supply (30) which has an electricity store (34) for storing electrical energy and which is designed at least to supply the respiratory gas conveying apparatus (13) with electricity.
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
A61M 16/10 - Preparation of respiratory gases or vapours
A61M 16/16 - Devices to humidify the respiration air
95.
PIPETTING UNIT WITH CAPACITIVE LIQUID DETECTION FUNCTION, COMBINATION OF SUCH A PIPETTING UNIT AND A PIPETTE TIP, AND METHOD FOR CAPACITIVELY DETECTING PIPETTING LIQUID
The invention relates to a pipetting unit (2) with a capacitive liquid detection function, comprising: a pressure tube (10); a shield (12) which is arranged about the pressure tube (10); a coupling (14) for temporarily securing a pipette tip (4) to the pipetting unit (2), wherein an electric connection is established between the pressure tube (10) and the pipette tip (4) when the pipette tip (4) is connected; and an electric circuit (20) which is coupled to the pressure tube (10) and the shield (12), wherein the electric circuit (20) is designed to apply an electric signal which can change over time to the pressure tube (10), said signal allowing a capacitive detection of a contact between the pipette tip (4) and the pipetting liquid (112) when the pipette tip (4) is connected, and the electric circuit (20) is designed to connect the shield (12) to ground.
G01F 23/26 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01F 11/02 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
96.
Pipetting device for pulsed pipetting with a pipetting piston movement controlled on the basis of a detection of the piston position
A pipetting device includes a pipetting channel at least partially filled with working gas, a pipetting tip accessible through a pipetting opening such that the volume of dosing liquid drawn into the receiving chamber can be varied by changing the pressure of the working gas in the receiving chamber, a pipetting piston for changing the pressure of the working gas and accommodated in the pipetting channel to be movable along the pipetting channel, a drive driving the pipetting piston to perform a movement along the pipetting channel, a control device controlling the drive, and a pressure sensor sensing the pressure of the working gas. The control device controls the drive to generate a pressure pulse in the pipetting channel based on the pressure signal output by the pressure sensor whereby the pressure of the working gas during the pulse follows a predefined working gas target pressure pulse curve.
The invention relates to a connection component (10) for a tracheal cannula (57). The connection component (10) surrounds a cavity (20), and the connection component (10) is open both at a coupling region (12) of the connection component (10) as well as at an opening region (16) of the connection component (10), said opening region being located at a different location than the coupling region (12), in order to provide access to the cavity (20). The connection component (10) has a latching formation (38) at the coupling region (12), said latching formation being designed to releasably connect to a mating latching formation (60) of the tracheal cannula (57), wherein the coupling region (12) surrounds a section of the cavity, and the cavity (20) section surrounded by the coupling region (12) is designed such that a virtual coupling axis (K) passes centrally through the cavity. The coupling axis (K) defines an axial direction (a) along the course of the coupling axis, a plurality of radial directions (r) orthogonally to the course of the coupling axis, and a circumferential direction (u) circumferentially about the coupling axis, and the coupling region (12) has at least one support section (26, 28) on which the latching formation (38) and an active region (36) are arranged such that the support section (26, 28) can be moved between two different positions with different radial distances between the latching formation (38) arranged on the support section (26, 28) and the coupling axis (K) by exerting an actuation force onto the active region (36) in the radial direction on the coupling axis (K). According to the invention, the active region (36) and the latching formation (38) of the same support section (26, 28) are arranged at an axial distance (d) to each other along the coupling axis (K).
A device for monitoring a biological process in a liquid medium includes a wall portion, a silanization layer and a sensor arrangement. The device attaches to a container of a bioreactor and can be used with disposable bioreactors. The wall portion is adapted to retain the liquid medium during operation of the bioreactor. A through-hole is disposed in the wall portion. A silanization layer covers the surface encircling the through-hole and the wall portion between the liquid medium and the wall portion. The sensor arrangement includes a glass layer, a substrate and an electrode. The glass layer is bonded by an adhesive to the silanization layer so as to cover the through-hole. The electrode is mounted on the substrate and measures electrical conductivity through the liquid medium. The sensor arrangement also includes an optical sensor that detects electromagnetic radiation that passes from the liquid medium through the glass layer.
The present invention relates to a ventilation device (10) for mechanical ventilation 1200 of patients, comprising an operating device for setting at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112, 114, 116, 120, 122, 130), having a manipulation element (22) that can be manually operated by an operator to manually set the at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112, 114, 116, 120, 122, 130), and a control unit (100) that is designed to automatically determine a target value for the at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112, 114, 116, 120, 122, 130) on the basis of detected values of characteristic variables; the operating device has a first haptic feedback unit associated therewith which is designed to control the manipulation element (22) in terms of a first haptic feedback such that a position of the manipulation element (22) corresponding to the target value of the at least one ventilation parameter (110, 112, 114, 116; 112, 110, 112, 114, 116, 120, 122, 130) determined by the control unit (100) is emphasized such that it is perceptible for the operator.
A61M 16/00 - Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators Tracheal tubes
100.
METHOD FOR CARRYING OUT A P/V MANEUVER WHICH AUTOMATICALLY PREVENTS AN OVER-DILATION OF THE LUNGS, AND VENTILATION DEVICE DESIGNED TO CARRY OUT THE METHOD
The invention relates to a ventilation device (10) for artificially ventilating a patient (12), the controller (18) of the ventilation device being designed to actuate a flow modifying device (16) for carrying out a P/V maneuver, in which a patient (12) is supplied with respiratory gas while the pressure of the respiratory gas is increased during an inspiration phase, said respiratory gas passively flowing out of the patient during an expiration phase after the pressure increase is terminated. For a plurality of respiratory gas pressures, the respective maneuver respiratory gas volume present in the patient as a result of the P/V maneuver is ascertained in connection with the present respiratory gas pressure during the inspiration phase as well as during the expiration phase. According to the invention, the controller (18) is designed to - ascertaining a sequence of lung compliance values during the inspiration phase on the basis of signals of a flow sensor assembly (44) and a pressure sensor assembly (27), - ascertain a reference compliance value in accordance with the sequence of compliance values, - on the basis of the reference compliance value, determine a termination compliance value, which differs from the reference compliance value in terms of amount, in the form of a threshold value as a termination criterion for the inspiration phase, and - terminate the inspiration phase if the termination compliance value is reached or exceeded.
