A surface-modified particle includes a core containing at least one oxidic material and at least one layer. The layer is obtained from at least one silicon compound and at least one silane according to formula(S). The silicon compound includes at least one building block of formula (A) and at least one building block of formula (B). A method is developed for preparing the surface-modified particle, and another method treats a surface of a substrate with at least one surface-modified particle. The surface-modified particle is added to various formulations, in particular a toner composition.
There is presented an in situ method of degradation of a fluoro-organic compound in an aqueous environment comprising at least soil and groundwater, the method comprising at least the steps of: (a) adding a sorptive media to the aqueous environment, the sorptive media being one or more of the group comprising: carbon, reactive organic and zero valent metal; (b) allowing the fluoro-organic compound to fix onto the sorptive media over a time period of greater than 24 hours; (c) providing an oxidant being reactive to the sorptive media; and (d) adding the oxidant to the aqueous environment to contact the sorptive media in situ at an oxidant concentration of ≥0.4M, and to initiate degradation of the fluoro-organic compound on the sorptive media when the temperature of the sorptive media is at least 65°C, so that one or more fluoro-degradation products are formed. The method relates to the in situ degradation of volatile and semi-volatile organic compounds, pesticides and other recalcitrant organic compounds in soil and groundwater, and includes soil remediation.
B09C 1/08 - Reclamation of contaminated soil chemically
C02F 1/58 - Treatment of water, waste water, or sewage by removing specified dissolved compounds
B09C 1/06 - Reclamation of contaminated soil thermally
B01J 20/00 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof
An aged aqueous antimicrobial composition is prepared by mixing a carboxylic acid selected from maleic acid, crotonic acid, malic acid, tartaric acid, malonic acid, citric acid and mixtures thereof, with hydrogen peroxide; reacting the mixture to form a percarboxylic acid; and ageing the mixture that has the percarboxylic acid for at least 14 days.
A01N 37/36 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio-analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
A process for sterilization or disinfection treatment includes: a) obtaining a hydrogen peroxide vapour from an aqueous hydrogen peroxide solution having a dry residue determined at 105° C. of at most 5 ppm and a total content of Fe, Cr, Mn and Ni in the solution of at most 6 ppb as determined by ICP-MS analysis; and b) treating an object to be sterilized or disinfected with the hydrogen peroxide vapour obtained in a).
The present invention relates in general to compositions and methods for treating an animal or human patient in need of treatment for ophthalmic diseases or conditions involving oxidative stress and treatment with an ophthalmic implant containing (2R,2R')-3,3'-disulfanediyl bis(2-acetamidopropanamide) (diNACA), wherein such ophthalmic diseases or conditions include but not limited to cataracts, cataracts in a subject that does not have diabetes, corneal endothelial cell loss, age-related macular degeneration, presbyopia, retinitis pigmentosa (RP), Usher syndrome, Stargardt syndrome, glaucoma, diabetic retinopathy, and/or retinal disease.
The present invention discloses a method for increasing a conversion rate of a (trans)esterification reaction for preparing a (meth)acrylate product.of a reaction mixture in a reactor system, the reactor system comprising a reboiler, a reaction chamber comprising the reaction mixture, a column with a column head, a vapor transfer line, a condenser, a reflux tank, a reflux line, a distillate take off line, and a receiver vessel, wherein the reaction mixture comprises at least one starting material which is converted by the reaction into at least one product, wherein the reaction mixture comprises (meth)acrylic acid as first starting material and a first alcohol as second starting material which are converted by the esterification reaction into a (meth)acrylate as a first product and water as a second product, or wherein in case of a transesterification reaction the reaction mixture comprises a (meth)acrylate as first starting material and a first alcohol as second starting material which are converted by the transesterification reaction into a second (meth)acrylate as a first product and a second alcohol as a second product, wherein while the reaction is running at least a portion of at least one of the products is removed by distillate take off, wherein the conversion rate of the reaction is increased by an intermediate increased or full removal of the at least one of the products present in the column, the column head and the condenser, and wherein - the intermediate increased or full removal of the at least one of the products present in the column, the column head, and the condenser while the reaction is running is performed by maximizing distillate take off and/or - during the intermediate increased or full removal of the at least one of the products present in the column, the column head and the condenser, the filling level for the reflux tank is minimized and the concentration of the removed products in the distillate is below a concentration of 50 wt%.
The organophilic clay comprises a smectite-type clay ion exchanged with quaternary ammonium ions, where at least 75 mol-% of said quaternary ammonium ions are bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters and at least 90% of the fatty acid moieties of the bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters have a structure RC(O) with group R being a linear alkyl or alkenyl group containing from 9 to 21 carbon atoms. The organophilic clay is useful for thickening oil based compositions, in particular drilling fluids for drilling oil or gas wells, comprising an oil phase.
The present invention relates to a surface-modified particle for use in a toner composition, a method of preparing the surface-modified particle according to the invention, a method for treating a surface of a substrate with at least one particle according to the invention, a substrate having a treated surface with at least one particle according to the invention, use of the at least one surface- modified particle according to the invention as additive in various formulations and in particular a toner composition comprising the surface-modified particle according to the invention.
The present invention relates to an aged aqueous antimicrobial composition prepared by (a) mixing a carboxylic acid selected from maleic acid, crotonic acid, malic acid, tartaric acid, malonic acid, citric acid or mixtures thereof, with hydrogen peroxide; (b) reacting the mixture obtained in step a) to form a percarboxylic acid; and c) ageing the mixture comprising the percarboxylic acid for at least 14 days.
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
A01N 37/06 - Unsaturated carboxylic acids or thio-analogues thereofDerivatives thereof
A01N 37/36 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio-analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
The present invention relates to an aqueous antimicrobial composition with a low odor, comprising (a) a first volatile carboxylic acid, (b) a second non-volatile carboxylic acid, (c) a first percarboxylic acid, (d) a second percarboxylic acid, and (e) hydrogen peroxide, wherein the molar ratio of the sum of the first carboxylic acid and the first percarboxylic acid to the sum of the second carboxylic acid and the second percarboxylic acid is from 1:5 to 5:1, preferably from 1:3 to 3:1, a process for producing thereof and the use thereof for antimicrobial treatment.
A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
A01N 37/06 - Unsaturated carboxylic acids or thio-analogues thereofDerivatives thereof
A01N 59/00 - Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
A23B 4/12 - Preserving with acidsAcid fermentation
A23B 7/10 - Preserving with acidsAcid fermentation
A01N 37/36 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio-analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio-analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
A process for sterilization or disinfection treatment, comprising the following steps: a) obtaining a hydrogen peroxide vapour from an aqueous hydrogen peroxide solution having a dry residue determined at 105 °C of at most 5 ppm and a total content of Fe, Cr, Mn and Ni in the solution of at most 6 ppb as determined by ICP-MS analysis; b) treatment of an object to be sterilized or disinfected with a hydrogen peroxide vapour obtained in step a).
The present invention relates to a composition suitable for manufacturing of sheet molding compounds, a method for preparing said composition, a method for making an article using said composition, an article with said composition, a mobility device comprising at least one such article. It is further directed at the use of at least one silane, a hydrolysate, an oligomer or a polymer thereof, to control the viscosity of a liquid mixture comprising an unsaturated polyester and at least one hollow glass body.
C03C 17/00 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating
C03C 17/30 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with organic material with silicon-containing compounds
C08J 3/205 - Compounding polymers with additives, e.g. colouring in the presence of a liquid phase
C09D 183/00 - Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon onlyCoating compositions based on derivatives of such polymers
C08K 9/06 - Ingredients treated with organic substances with silicon-containing compounds
C08K 9/08 - Ingredients agglomerated by treatment with a binding agent
z in the range of 1 to 450 nm, and with a polydispersity index PDI in the range of 0.01 to 0.5. The process involves emulsion-solvent extraction or emulsion-solvent evaporation, and application of ultrasonic sound.
The present invention generally relates to methods for curing and/or manufacturing silicone-coated release liners used e.g., in the production of pressure sensitive, peel-and-stick labels. In particular, the present invention is directed to silicone release coatings curable by LED, and methods for preparing silicone release coatings and curing such coatings with or without the need for nitrogen inerting or the addition of oxygen scavengers.
C09D 183/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
C09J 4/06 - Adhesives based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups
C09J 183/06 - Polysiloxanes containing silicon bound to oxygen-containing groups
The present invention concerns an anti-corrosion agent, a kit-of-parts for preparing said anti-corrosion agent, a method for preparing said anti-corrosion agent and an anti-corrosion layer as well as a method for providing said layer.
C09D 183/14 - Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon, with or without sulfur, nitrogen, oxygen, or carbon onlyCoating compositions based on derivatives of such polymers in which at least two but not all the silicon atoms are connected by linkages other than oxygen atoms
Aqueous solutions of peroxyacids are stabilized by a polymeric stabilizer selected from a phosphino polycarboxylic acid, a poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid co-polymer, or a poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid-sulfonated styrene terpolymer. The polymer-stabilized peroxyacid solutions have applications in aseptic sterilization and disinfecting of surfaces.
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
A01N 25/22 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
A01N 37/16 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group Thio-analogues thereof
19.
PROCESS FOR PREPARING NANOPARTICLES IN THE FORM OF A POWDER COMPRISING A BIO-RESORBABLE POLYESTER
The invention is concerned with a process for preparing nanoparticles, comprising at least one bio-resorbable polyester, in the form of a powder with a Z-Average particle size Dz in the range of 1 to 450 nm, with a polydispersity index PDI in the range of 0.01 to 0.5, by emulsion-solvent extraction or emulsion-solvent evaporation and application of ultrasonic sound.
B01J 19/10 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor employing sonic or ultrasonic vibrations
C08J 3/16 - Powdering or granulating by coagulating dispersions
20.
Organophilic clays and drilling fluids containing them
The organophilic clay comprises a smectite-type clay ion exchanged with quaternary ammonium ions, where at least 75 mol-% of said quaternary ammonium ions are bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters and at least 90% of the fatty acid moieties of the bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters have a structure RC(O) with group R being a linear alkyl or alkenyl group containing from 9 to 21 carbon atoms. The organophilic clay is useful for thickening oil based compositions, in particular drilling fluids for drilling oil or gas wells, comprising an oil phase.
Cannabinoid may be separated from plant extract by mixing polar solvent and plant extract and subjecting the resulting mixture to a first nanofiltration operation including a silicone acrylate membrane layer on a polyimide support. Permeate from the first nanofiltration operation may be subjected to a second nanofiltration operation to provide a retentate enriched in cannabinoid compound and a second permeate including the solvent. The second nanofiltration operation may include the use of a membrane having a molecular weight cut off of between 150 g/mol and 350 g/mol.
The invention relates to functionalized polymers, a process for producing functionalized polymers and the use of functionalized polymers, especially in the field of personal care.
C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61Q 1/02 - Preparations containing skin colorants, e.g. pigments
Described herein are packages for orienting and cooling polyesters during a sterilization process, and containers for storing, transporting, and cooling the package. Also described herein are methods of sterilizing polyesters.
B65D 81/18 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
24.
A DEVICE AND A MEMBRANE PROCESS FOR SEPARATING GAS COMPONENTS FROM A GAS STREAM HAVING VARYING COMPOSITION OR FLOW RATE
A device for separating a gas stream which has a compressor and three membrane separation units in series, connected to pass the retentate stream of each of the first two units to the subsequent membrane separation unit, comprises conduits for recycling the permeate streams of the second and the third membrane separation unit to upstream of the compressor and a control device controlling the fraction of the second permeate stream which is recycled. Adjusting which fraction of the second permeate is recycled can be used to maintain a target composition of the retentate obtained in the third membrane separation unit when the flow rate or the composition of the gas stream changes.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
C10L 3/10 - Working-up natural gas or synthetic natural gas
B01D 53/30 - Controlling by gas-analysis apparatus
The present invention is directed to an improved purification process using additive and activated carbon for purifying resorbable polymers suitable for industrial manufacturing. The metal catalyst concentration in the purified resorbable polymers of this invention is preferably less than 1 ppm. The method can be used to obtain high molecular weight polymers that are substantially metal free.
Aqueous solutions of peroxyacids are stabilized by a polymeric stabilizer selected from a phosphino polycarboxylic acid, a poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid copolymer, or a poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid-sulfonated styrene terpolymer. The polymer-stabilized peroxyacid solutions have applications in aseptic sterilization and disinfecting of surfaces.
A01N 25/22 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
A01N 37/16 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group Thio-analogues thereof
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
27.
PROCESS FOR PREPARING A STABILIZED AQUEOUS HYDROGEN PEROXIDE SOLUTION
In a process for preparing hydrogen peroxide by an anthraquinone process, comprising hydrogenating a working solution comprising an anthraquinone compound, oxidizing the hydrogenated working solution to form hydrogen peroxide and extracting the hydrogen peroxide with water, the extracted aqueous hydrogen peroxide solution is stabilized with one or more oxidizer stable polymeric stabilizers.
Aqueous solutions of peroxyacids are stabilized by a polymeric stabilizer selected from a phosphino polycarboxylic acid, a poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid copolymer, or a poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid-sulfonated styrene terpolymer. The polymer-stabilized peroxyacid solutions have applications in aseptic sterilization and disinfecting of surfaces.
A01N 37/16 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group Thio-analogues thereof
A01N 25/22 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
A01P 1/00 - DisinfectantsAntimicrobial compounds or mixtures thereof
Aqueous solutions of hydrogen peroxide and alkali metal chlorate are stabilized by a polymeric stabilizer selected from phosphino polycarboxylic acid, poly(acrylic acid), a poly(acrylic acid)- acrylamidoalkylpropane sulfonic acid co-polymer and a poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid-sulfonated styrene terpolymer.
Aqueous solutions of hydrogen peroxide are stabilized by at least one polymeric stabilizer selected from phosphino polycarboxylic acids, poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid co-polymers and poly(acrylic acid)-acrylamidoalkylpropane sulfonic acid-sulfonated styrene terpolymers. The polymer-stabilized hydrogen peroxide solutions have applications in aseptic packaging, electronics manufacture, and pulp and paper bleaching.
A modified colloidal silica is produced by mixing an effective amount of an alkyl silicate to form a colloidal silica, followed by treating the colloidal silica with an effective amount of a polyethersilane to form a modified colloidal silica.
A wearable device (204) comprising: a base coupled to a user; a recessed portion formed in the base; a microneedle array (200) supported by the base wherein the microneedle array includes a plurality of microneedles; and an actuator (208) coupled to the microneedle array to move the microneedle array into and out of the recessed portion in the base.
Described herein are microneedle arrays for delivery of medicinal formulations. The microneedle arrays includes an anchoring system for securing the microneedle arrays to the skin for a period of time, e.g., a treatment period. The microneedles in the array also may include a coating, such as a lubricious coating for ease of puncturing/penetrating the skin or anti-microbial agents.
The invention relates to functionalized polymers, a process for producing functionalized polymers and the use of functionalized polymers, especially in the field of personal care.
Described herein are packages for orienting and cooling polyesters during a sterilization process, and containers for storing, transporting, and cooling the package. Also described herein are methods of sterilizing polyesters.
Described herein are packages for orienting and cooling polyesters during a sterilization process, and containers for storing, transporting, and cooling the package. Also described herein are methods of sterilizing polyesters.
The present invention is directed to an improved purification process using additive and activated carbon for purifying resorbable polymers suitable for industrial manufacturing. The metal catalyst concentration in the purified resorbable polymers of this invention is preferably less than 1 ppm. The method can be used to obtain high molecular weight polymers that are substantially metal free.
The present invention is directed to an improved purification process using additive and activated carbon for purifying resorbable polymers suitable for industrial manufacturing. The metal catalyst concentration in the purified resorbable polymers of this invention is preferably less than 1 ppm. The method can be used to obtain high molecular weight polymers that are substantially metal free.
Salt-tolerant friction-reducing terpolymer compositions are provided. The compositions can be used in a method of reducing friction resulting from turbulent flow in an aqueous fracturing fluid in a subterranean fracturing process.
The organophilic clay comprises a smectite-type clay ion exchanged with quaternary ammonium ions, where at least 75 mol-% of said quaternary ammonium ions are bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters and at least 90% of the fatty acid moieties of the bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters have a structure RC(O) with group R being a linear alkyl or alkenyl group containing from 9 to 21 carbon atoms. The organophilic clay is useful for thickening oil based compositions, in particular drilling fluids for drilling oil or gas wells, comprising an oil phase.
The organophilic clay comprises a smectite-type clay ion exchanged with quaternary ammonium ions, where at least 75 mol-% of said quaternary ammonium ions are bis-(2-hydroxypropyl)- dimethylammonium fatty acid esters and at least 90 % of the fatty acid moieties of the bis-(2-hydroxypropyl)-dimethylammonium fatty acid esters have a structure RC(O) with group R being a linear alkyl or alkenyl group containing from 9 to 21 carbon atoms. The organophilic clay is useful for thickening oil based compositions, in particular drilling fluids for drilling oil or gas wells, comprising an oil phase.
C01B 33/36 - Silicates having base-exchange properties but not having molecular sieve properties
C01B 33/38 - Layered base-exchange silicates, e.g. clays, micas or alkali metal silicates of kenyaite or magadiite type
C01B 33/44 - Products obtained from layered base-exchange silicates by ion-exchange with organic compounds such as ammonium, phosphonium or sulfonium compounds or by intercalation of organic compounds, e.g. organoclay material
The use of a single phase aqueous hydrogen peroxide composition, comprising from 5 to 75 % by weight of hydrogen peroxide and from 3 to 150 mg/kg of at least one alkyl phosphate, the composition having a total organic carbon content from organic compounds other than alkyl phosphates of less than 200 mg/kg, reduces foam formation in a method for producing chlorine dioxide by reacting an alkali chlorate with hydrogen peroxide composition in an acidic aqueous medium boiling at sub-atmospheric pressure.
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses
C09D 4/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
C09D 5/00 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects producedFilling pastes
The disclosure is directed in part to extended release compositions that include hydroxy progesterone caproate. For example, provided herein is a therapeutic microparticle composition comprising a plurality of microparticles, wherein the microparticles each comprise poly (lactide-co-glycolide) and hydroxyprogesterone caproate.
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
chemical reagents, other than for medical or veterinary purposes, namely, formulated reagents for the remediation of contaminants in soil and groundwater environments
01 - Chemical and biological materials for industrial, scientific and agricultural use
Goods & Services
Lecithin-based substrate of food-grade organic carbon used to enhance anaerobic bioremediation; organic carbon substrate used for bioremediation of contaminated soil and groundwater; chemicals used in industry, science and photography, as well as in agriculture, horticulture and forestry.
49.
FRICTION REDUCING TERPOLYMER COMPOSITIONS AND METHOD OF FRACTURING
Salt-tolerant friction-reducing terpolymer compositions are provided. The compositions can be used in a method of reducing friction resulting from turbulent flow in an aqueous fracturing fluid in a subterranean fracturing process.
C09K 8/68 - Compositions based on water or polar solvents containing organic compounds
C09K 8/88 - Compositions based on water or polar solvents containing organic compounds macromolecular compounds
C08F 216/02 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical by an alcohol radical
Salt-tolerant friction-reducing terpolymer compositions are provided. The compositions can be used in a method of reducing friction resulting from turbulent flow in an aqueous fracturing fluid in a subterranean fracturing process.
Compositions and methods of making and using of microparticle compositions that provide faster flow or improved injectability through smaller or small-diameter needles have been developed. Notably, the microparticle compositions can be successfully delivered or administered through smaller-diameter needles than other microparticle compositions prepared from biocompatible or biodegradable polymers including, for example, poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate. The microparticle compositions can exhibit a higher solids loading for a given needle size and/or faster flow through needles than other microparticle compositions. Further, blending or mixing the polymer of the microparticle composition with other polymer formulations can enhance the injectability of the resulting formulation.
The present invention is directed to a method for the treatment of an environmental medium contaminated with arsenic, comprising treating such medium with an effective amount of persulfate and zero valent iron.
The apparatus and methods of the present invention are of use for the production of emulsion-based microparticles containing a biological or chemical agent. In particular, the apparatus provides a vessel; packing material situated inside such vessel and may further provide material capable of insertion into both ends of said vessel for enclosure of the packing material. In a particular embodiment, the apparatus is a packed bed apparatus. The methods include production of emulsion based microparticles containing a biological or chemical agent. The usefulness of the present invention is that the apparatus and methods of the present invention provide for a low-shear, non-turbulent, production of emulsion-based microparticles that provides a narrow, reproducible, particle size distribution, capable of use with both large and small volumes that is capable of being conveniently scaled up while providing predictable emulsion properties.
A61K 31/565 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
B01F 3/08 - Mixing, e.g. dispersing, emulsifying, according to the phases to be mixed liquids with liquids; Emulsifying
B01J 2/06 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
C08J 3/14 - Powdering or granulating by precipitation from solutions
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
55.
PARTICULATE SUPERABSORBENT POLYMER COMPOSITION HAVING IMPROVED STABILITY
The present invention relates to a particulate superabsorbent polymer composition comprising a polymer comprising a neutralized aluminum salt solution applied to the surface of a particulate superabsorbent polymer; wherein an aqueous solution of the neutralized aluminum salt has a pH value from about 5.5 to about 8 and the particulate superabsorbent polymer composition has a mean particle size distribution of from 300 to 400μm, an original Free Swell Gel Bed Permeability (FSGBP) of about 20x10-8 cm2 to about 200x10-8 cm2; and subsequent to subjecting the particulate superabsorbent polymer composition to the Processing Test, the particulate superabsorbent polymer composition has a permeability stability index of from about 0.60 to about 0.99 and having particles having a particle diameter of larger than 600μm in an amount of less than about 15wt% of the particulate superabsorbent polymer composition and as specified by standard sieve classification.
B01J 20/00 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof
56.
PARTICULATE SUPERABSORBENT POLYMER COMPOSITION HAVING IMPROVED STABILITY AND FAST ABSORPTION
The present invention relates to a fast particulate superabsorbent polymer composition comprising a polymer comprising a neutralized aluminum salt solution applied to the surface of a particulate superabsorbent polymer; wherein an aqueous solution of the neutralized aluminum salt has a pH value from about 5.5 to about 8; and subsequent to subjecting the particulate superabsorbent polymer composition to the Processing Test, the particulate superabsorbent polymer composition has a permeability stability index of from about 0.60 to about 0.99, and a compressibility from 1.30mm2/N to about 4mm2/N as measured by the Compression Test, and wherein the particulate superabsorbent polymer composition may have a Vortex time of from 25 to 60 seconds and absorbency under load at 0.9psi of from 15 to 21g/g.
B01J 20/00 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof
57.
PARTICULATE SUPERABSORBENT POLYMER COMPOSITION HAVING IMPROVED STABILITY
The present invention relates to a particulate superabsorbent polymer composition comprising a polymer comprising a neutralized aluminum salt solution applied to the surface of a particulate superabsorbent polymer; wherein an aqueous solution of the neutralized aluminum salt has a pH value from about 5.5 to about 8 and the particulate superabsorbent polymer composition has a mean particle size distribution of from 300 to 400μm, an original Free Swell Gel Bed Permeability (FSGBP) of about 20x10-8 cm2 to about 200x10-8 cm2; and subsequent to subjecting the particulate superabsorbent polymer composition to the Processing Test, the particulate superabsorbent polymer composition has a permeability stability index of from about 0.60 to about 0.99 and having particles having a particle diameter of larger than 600μm in an amount of less than about 15wt% of the particulate superabsorbent polymer composition and as specified by standard sieve classification.
Detergent compositions and detergent compositions dispersed in personal care products are provided herein. In one embodiment, a detergent composition is provided and comprises a sorbent carrier. The detergent composition also includes a sorbed component including an acid and a surfactant. The sorbed component is sorbed by the sorbent carrier.
Described herein are drying methods for tuning one or more properties of a microparticle. In one aspect, the release profile of a microparticle comprising a bioactive agent therein can be affected by the disclosed drying methods.
The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.
The present invention is directed to a method of oxidizing an organic compound present in soil, groundwater, process water or wastewater comprising contacting such organic compound with a persulfate and an organic acid selected from the group consisting of ascorbic acid, formic acid, oxalic acid, lactic acid and citric acid, wherein the molar ratio of such organic acid to persulfate is between 1:100 and 3:1.
The invention relates to a superabsorbent copolymer comprising a reaction product of a reactive optical brightener comonomer. In another embodiment, the superabsorbent copolymer comprises a reaction product of a first monomer and a reactive optical brightener comonomer. The reactive optical brightener comonomer may be selected from various pyrene optical brighteners listed herein. The invention also relates to superabsorbent copolymer having from about 0.1 to 10,000 ppm of a reactive optical brightener comonomer based on the superabsorbent copolymer.
The present invention further relates to a process to make a superabsorbent polymer comprising the steps of a) preparing a neutralized monomer solution comprising a polymerizable monomer selected from unsaturated acid groups-containing monomers, ethylenically unsaturated carboxylic acid anhydride, salts, or derivatives thereof and a caustic agent selection from an alkali agent, wherein the polymerizable monomer is neutralized to from about 50mol% to about 85mol%; b) forming a crosslinker monomer mixture by adding an internal crosslinker composition to the neutralized monomer solution wherein the internal crosslinking composition is the reaction product of a stoichiometric excess of amine with a glycidyl compound, wherein the internal crosslinker composition has a residual amount of glycidyl compounds of less than about 500ppm based on the mass of the internal crosslinker composition; and c) polymerizing the crosslinker monomer mixture to make a superabsorbent polymer.
The present invention further relates to a particulate superabsorbent polymer composition comprising a crosslinker composition that is the reaction product selected from (i) saturated amines and/or saturated polyamines with ethylenically unsaturated glycidyl compounds and/or ethylenically unsaturated polyglycidyl compounds, (ii) ethylenically unsaturated amines and/or ethylenically unsaturated polyamines with saturated glycidyl compounds and/or saturated polyglycidyl compounds, or (iii) ethylenically unsaturated amines and/or ethylenically unsaturated polyamines with ethylenically unsaturated glycidyl compounds and/or ethylenically unsaturated polyglycidyl compounds; and a surface crosslinking agent applied to the particle surface. The present invention further relates to an absorbent article that includes such particulate superabsorbent polymer compositions.
Disclosed herein are process for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications.
Disclosed herein are biocompatible and biodegradable polymers which are useful in tissue engineering, wound healing, coatings, and drug delivery, the polymers comprising one or more ECM-mimetic peptides and one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof. Further disclosed herein are methods for making and using the disclosed biocompatible polymers.
A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
The present invention relates to a particulate superabsorbent polymer composition which absorbs water, aqueous liquids, and blood, and a process to make the superabsorbent polymers, wherein a superabsorbent polymer is surface treated with a neutralized multivalent metal salt solution having a pH value similar as that of human skin. The present invention also relates to particulate superabsorbent polymer composition having high Gel Bed Permeability and high Absorbency Under Load.
Disclosed herein are apparatus and methods for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions. Disclosed herein are columns for receiving a packing material that permits fluid flow through the column. The columns have a periphery that defines an interior cavity in fluid communication with inlets and outlets of the column. Disclosed herein is a method of preparing an emulsion that includes (1) forming a first phase typically containing an organic solvent, a polymer, and one or more biologically active agents and/or chemicals; (2) forming a second phase typically containing water as the second solvent, an emulsion stabilizer and optionally a solvent; and (3) passing the first and the second phases through the column to form a “water in oil” type emulsion.
Disclosed herein are an apparatus and a method for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions. The apparatus relates to a column (10) for receiving a packing material, wherein at least one divider (50) is positioned within the interior cavity of the column, each divider of the at least one divider extending at least a position of the longitudinal length of the interior cavity and being configure to partition the packing material.
Disclosed herein are an apparatus and a method for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions. The apparatus relates to a column (10) for receiving a packing material, wherein at least one divider (50) is positioned within the interior cavity of the column, each divider of the at least one divider extending at least a position of the longitudinal length of the interior cavity and being configure to partition the packing material.
Disclosed herein are branched polyol polyesters, which are useful in pharmaceutical formulations. Also disclosed are blends, microparticles, and other formulations, comprising the branched polyol polyesters.
Disclosed herein are methods comprising suspending microparticles in a surfactant/non-polar alkane solution to remove residual solvent that is present in the microparticle.
The method disclosed herein comprises using a non-polar alkane in the continuous phase of an emulsion process to aid in the removal of dispersed phase solvent from the microparticles. The microparticles can further be subjected to a post-production treatment process, involving a non-polar alkane suspension and a rinse, to further reduce residual dispersed phase solvent levels.
A drug delivery blade for delivering a drug depot to a treatment site in a patient is disclosed. The drug delivery blade includes a shaft defining a longitudinal axis of the blade, a lumen that extends longitudinally from a proximal end of the shaft to a distal end of the shaft, a first beveled cut that forms a sharpened tip at the distal end of the shaft, and a flared portion near the distal end of the shaft. The flared portion of the blade includes two radially- extending blade segments having sharpened leading edges that allow the drug delivery blade to cut tissue when the blade is advanced toward a treatment site. Methods of using the drug delivery blade are also disclosed.
The disclosed process comprises freeze-drying a biodegradable implant device comprised or one or more polyesters to thereby reduce moisture content in the device.
Disclosed herein are terpolymers and blends prepared from polyester terpolymers that can function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymer and terpolymer blends coated to a conformable backing member. The terpolymer and terpolymer blends can further comprise a bioactive agent.
C09J 7/00 - Adhesives in the form of films or foils
C09J 167/00 - Adhesives based on polyesters obtained by reactions forming a carboxylic ester link in the main chainAdhesives based on derivatives of such polymers
Disclosed herein are terpolymers that can function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymers adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive terpolymer adhered to a surface thereof. The pressure-sensitive adhesive terpolymer can promote adhesion of the implant device to a location in a subject.
Disclosed herein are blends prepared from polyester terpolymers that function as pressure-sensitive adhesives. The disclosed articles comprise the terpolymer blends adhered to a release liner. The disclosed implant devices comprise the pressure-sensitive adhesive blend adhered to a surface thereof. The pressure-sensitive adhesive blend can promote adhesion of the implant device to a location in a subject.
The disclosed process comprises freeze-drying a biodegradable implant device comprised or one or more polyesters to thereby reduce moisture content in the device.
The core-sheath implant device allows for a bioactive agent release profile that can be tailored to a particular therapy. The device features one or more lobes extending from an inner core at least partially through the outer sheath. Depending on the particular design of such an implant device, a variety of release profiles can be achieved.
The core-sheath implant device allows for a bioactive agent release profile that can be tailored to a particular therapy. The device features one or more lobes extending from an inner core at least partially through the outer sheath. Depending on the particular design of such an implant device, a variety of release profiles can be achieved.
The core-sheath implant device allows for a bioactive agent release profile that can be tailored to a particular therapy. The device features one or more lobes extending from an inner core at least partially through the outer sheath. Depending on the particular design of such an implant device, a variety of release profiles can be achieved.
Disclosed herein are process for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications.
Disclosed herein are processes for preparing implants that are particularly useful for thermally labile bioactive agents but can also generally be used with any bioactive agent. The disclosed processes avoid the use of heat during processing and therefore avoid heat induced degradation of the bioactive agent. Also disclosed are implants prepared by the disclosed methods.
Disclosed herein are compositions comprising cross-linkers for cross-linking a retention vehicle polymer. The compositions are particularly useful for local administration of a bioactive agent, wherein prolonged or extended availability of the bioactive agent at the site of administration is desired. Also disclosed are methods of delivering the compositions to a subject.
Disclosed herein are compositions comprising cross-linkers for cross-linking a retention vehicle polymer. The compositions are particularly useful for local administration of a bioactive agent, wherein prolonged or extended availability of the bioactive agent at the site of administration is desired. Also disclosed are methods of delivering the compositions to a subject.
Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.
Disclosed herein are compositions comprising cross-linkers for cross-linking a retention vehicle polymer. The compositions are particularly useful for local administration of a bioactive agent, wherein prolonged or extended availability of the bioactive agent at the site of administration is desired. Also disclosed are methods of delivering the compositions to a subject.
Disclosed herein are surface-active biodegradable block copolymers comprising one or more hydrophobic blocks and one or more hydrophilic blocks. The surface-active polymers are used as stabilizers in emulsions which are used in microencapsulation processes. Also disclosed are microparticles prepared from the emulsions.
The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles.
The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles.
The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles.
Disclosed herein are processes for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications.
Disclosed herein are processes for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications.
Described herein are implant devices, kits comprising the implant devices, and methods of making and using the devices and kits. In one aspect, a plurality of implant devices comprises at least two implants that exhibit a different release profile of a bioactive agent. In another aspect, an implant device comprises one or more adjoined polymer bodies, wherein at least two of the polymer bodies provide a different release profile of a bioactive agent. In another aspect, a kit comprises one or more disclosed implant devices. In another aspect, methods of delivering a bioactive agent to a subject comprise administering to the subject one or more disclosed implant devices.
