The present disclosure provides for processes and systems that rely on software, bioinformatics, and robotics principles for actuating the automation of a workflow from nucleic acid extraction from a sample to sequencing without human intervention in between the aforementioned steps.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
2.
FULLY AUTOMATED SAMPLE PROCESSING PLATFORM FROM EXTRACTION TO SEQUENCING
The present disclosure provides for processes and systems that rely on software, bioinformatics, and robotics principles for actuating the automation of a workflow from nucleic acid extraction from a sample to sequencing without human intervention in between the aforementioned steps.
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
Provided herein are automated apparatus and methods for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by library preparation and sequencing.
Provided herein are fully-automated next-generation sequencing platforms and processes for detection of a target specimen (e.g., SARS-CoV-2) and for distinguishing infectious from non-infectious signals from the specimen. An analysis can provide simultaneous diagnosis and genomic surveillance of a multitude of distinct specimens in a sample information. The analysis can comprise distinguishing between infectious versus infectious specimens and provide a recommendation as to how infectious the sample can be. The information on can be used to better inform the status of a subject or a location with regards to infectivity from the specimen.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
Food processing facilities should employ environmental sampling programs to monitor for general levels of hygiene (the efficacy of general cleaning and sanitation for the removal of transient microorganisms). The instant disclosure provides kits, systems and methods for amplifying a portion of a genome of a pathogen at a plurality of physical locations within a facility; and associating, via a computer, the presence of said pathogen with a location of the plurality of physical locations within said facility.
Provided herein are fully-automated next-generation sequencing platforms and processes for detection of a target specimen (e.g., SARS-CoV-2) and for distinguishing infectious from non-infectious signals from the specimen. An analysis can provide simultaneous diagnosis and genomic surveillance of a multitude of distinct specimens in a sample information. The analysis can comprise distinguishing between infectious versus infectious specimens and provide a recommendation as to how infectious the sample can be. The information can be used to better inform the status of a subject or a location with regards to infectivity from the specimen.
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
Provided herein are automated apparatus for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by sequencing.
Provided herein are automated apparatus for the identification of microorganisms in various samples. The disclosure solves existing challenges encountered in identifying and distinguishing various types of microorganisms, including viruses and bacteria in a timely, efficient, and automated manner by sequencing.
Food processing facilities should employ environmental sampling programs to monitor for general levels of hygiene (the efficacy of general cleaning and sanitation for the removal of transient microorganisms).
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
Goods & Services
Laboratory supplies for testing pathogens, bacteria, viruses, fungi, protozoa, namely, sample collection kits comprised of testing sample collection equipment in the nature of pre-moistened medicated wipes and medicated swabs for use in diagnostic testing, for medical purposes and laboratory storage tubes Rental of laboratory apparatus, namely, robotic workstations having
multi-use work surfaces for use in a wide variety of fields,
thermocyclers, DNA sequencers, on-deck magnets for testing for
pathogens, bacteria, viruses, fungi, protozoa, and algae
09 - Scientific and electric apparatus and instruments
Goods & Services
Laboratory apparatus and instruments, namely, on-site robotic platforms in the nature of automated pipetting and thermal cyclers for laboratory analysis for polymerase chain reaction DNA sequencing, culturing, antigen-based testing and automated testing and analysis; Laboratory apparatus and instruments, namely, on-site robotic platforms in the nature of automated pipetting and thermal cyclers for laboratory analysis for identifying, characterizing, and subtyping genetic pathogen sequences for food safety testing
42 - Scientific, technological and industrial services, research and design
Goods & Services
laboratory services, namely, providing genetic testing services for research purposes through the genetic fingerprinting of bacteria from environmental surfaces and the comparison of the fingerprinting data to historical data
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific laboratory testing services for the
identification of the presence and absence of ingredients
and constituents of food and beverages; product testing for
purity; product testing, namely, testing for the presence of
heavy metals, toxins, allergens, additives, contaminants,
hormones, pesticides, antibiotics, and genetically modified
organisms; testing for nutritional data and product
authenticity; providing on-site robotic platforms for PCR,
DNA sequencing, culturing, antigen-based testing, automated
testing and analysis, including thermal cyclers, and related
supplies including reagents, primers, DNA probes,
oligonucleotides, pipette tips, enzymes, polymerases (term
considered too vague by the International Bureau - rule 13
(2) (b) of the Common Regulations).
14.
Detection of microorganisms in food samples and food processing facilities
Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
G16B 40/00 - ICT specially adapted for biostatisticsICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
G16B 50/00 - ICT programming tools or database systems specially adapted for bioinformatics
Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Providing quality control services to food and beverage manufactures in the nature of sampling surfaces for contaminants and pathogens in the nature of bacteria, viruses and other foreign substances, the identification and analysis of samples, and providing reports identifying the nature and locations of contaminants on food processing, packaging and handling equipment
18.
Detection of microorganisms in food samples and food processing facilities
Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
19.
Detection of microorganisms in food samples and food processing facilities
Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific laboratory testing services for the identification of the presence and absence of ingredients and constituents of food and beverages; Product testing for purity; Product testing, namely, testing for the presence of heavy metals, toxins, allergens, additives, contaminants, hormones, pesticides, antibiotics, and genetically modified organisms; Food safety testing for nutritional data and product authenticity; Rental of laboratory apparatus and instruments, namely, on-site robotic platforms for laboratory analysis, namely, for PCR DNA sequencing, culturing, antigen-based testing and automated testing and analysis including thermal cyclers
21.
APPARATUS AND METHOD FOR ECONOMIC, FAST AND EASY SAMPLING OF FOOD AND ENVIRONMENTAL SAMPLES
A handheld solid sample pipette device includes a pipette tube with a number of sharpened teeth adapted to pierce solid or substantially solid sample material, the pipette tube adapted to be matingly attached to a device that includes a handle, a plunger, and a piston within a shell of the device. A spring may be positioned to return the plunger to a non-depressed position following depression of the plunger. A sample of the material can be ejected from the handheld device. The handheld device may further include a shear ring apparatus, that in-turn includes a tube portion, a plurality of shear ring teeth, and a knobbed plate for rotating the shear ring. Following insertion of the pipette with sharpened teeth into the sample, the shear ring apparatus is pressed into the sample as well, such that the shear ring tube, which is slidingly engaged about the pipette tube, slides over the pipette tube into the sample. The shear ring teeth pierce the sample, and at a certain point of insertion, the shear ring apparatus is rotated in either or both a clockwise or counter-clockwise manner such that the shear ring teeth sever a portion of the material to be sampled such that the portion remains within the pipette tube, for removal, and analysis.
