Abstract

Embodiments of the present disclosure relate to a flexible device. The flexible device includes a flexible sensing slice. The flexible sensing slice includes: a combination of an ultrasound sensor and at least one bioelectrical sensor. The at least one bioelectrical sensor is fabricated by processing a polyimide film using a laser with Laser-Induced Graphene (LIG) as a sensing material, and the ultrasound sensor is placed on the polyimide film. The flexible sensing slice further includes: a Polydimethylsiloxane (PDMS) film encapsulating the combination of the ultrasound sensor and the at least one bioelectrical sensor.

IPC Classes  ?

• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61B 5/391 - Electromyography [EMG] of genito-urinary organs
• A61B 8/02 - Measuring pulse or heart rate
• A61B 8/08 - Clinical applications

Abstract

A computer-based method of pre-training a graph neural network for molecular graphs is provided. The method includes assigning a weight to each atom in a molecule of a molecular sample based at least on a number of atoms of each atomic type in the molecule, an atomic composition of the molecular sample is known, randomly masking a number of atoms in the molecule of the molecular sample based on the assigned weight of each atom, an atomic type having a higher number of atoms in the molecule has a lower probability of being masked, and pre-training the graph neural network using the masked molecular sample.

IPC Classes  ?

• G16C 20/70 - Machine learning, data mining or chemometrics

Abstract

A battery equalizer for a series-connected battery string. The battery equalizer contains a plurality of cell circuits, an AC link, and a DC/AC converter. The plurality of cell circuits at their input ends is connected in parallel with each other and to the AC link. Each cell circuit at its output end is adapted to connect to a corresponding battery cell of the battery string. The DC/AC converter connects to the AC link. Each of the cell circuits contains an AC/DC converter, and an AC side of the AC/DC converter is capacitively-coupled to the AC link at the input end of the cell circuit. As the current taken from the first stage is common to all battery cells, charging or discharging of individual battery cells is autonomously determined by the output current of the second stage.

IPC Classes  ?

• H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries

Abstract

A method for preparing a dry facial mask, comprising the steps: using water-soluble polymer, surfactant, ingredients comprising Chinese medicine to form a stock solution; electro-spinning the stock solution onto a substrate to form an intermediate facial mask; and drying the intermediate facial mask to form dry facial mask.

IPC Classes  ?

• A61K 8/020 -
• A61K 8/30 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
• A61K 8/72 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
• A45D 44/00 - Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
• A61Q 19/00 - Preparations for care of the skin

Abstract

A photovoltaic cell comprising a perovskite layer (110), an electron transporting layer (106) and an interface layer (108) disposed between the electron transporting layer and the perovskite layer. The interface layer comprises a metallocene substituted with a substituent having an O, S, N or P group, for example ferrocene substituted with a thienyl-carboxylate group.

IPC Classes  ?

• H10K 85/30 - Coordination compounds
• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/50 - Photovoltaic [PV] devices
• H10K 30/80 - Constructional details
• H10K 30/85 - Layers having high electron mobility, e.g. electron-transporting layers or hole-blocking layers
• H10K 39/12 - Electrical configurations of PV cells, e.g. series connections or parallel connections
• H10K 85/20 - Carbon compounds, e.g. carbon nanotubes or fullerenes
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3

Abstract

The present disclosures relate to the establishment of a plasmid-based reverse genetic system for TiLV and use of the system to rescue recombinant and reporter TiLVs. The present disclosures also relate to the plasmids used for the rescue of TiLV and the recombinant and reporter TiLVs generated using the methods disclosed herein.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/077 - Mesenchymal cells, e.g. bone cells, cartilage cells, marrow stromal cells, fat cells or muscle cells

Abstract

The present invention relates to a method for preparing a dry facial mask, comprising the following steps: dissolving a water-soluble polymer into water to form a first solution; adding surfactant into said first solution and then mixing them until dissolved to form a second solution; adding ingredients comprising Chinese medicine into said second solution, and then mixing them until dissolved to form a stock solution; electro-spinning said stock solution onto a substrate to form an intermediate facial mask; and drying said intermediate facial mask to form said dry facial mask.

IPC Classes  ?

• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61Q 19/00 - Preparations for care of the skin

Abstract

Disclosed in the present application are a data processing method, apparatus and device, and a computer-readable storage medium. The method comprises: using a policy network, a value function network and a tail risk network that are to be trained to interact with an environment for multiple times, so as to obtain a feedback sample set; using the feedback sample set to separately perform at least one round of training on the policy network, the value function network and the tail risk network; and after each network has undergone at least one round of training and a preset training finish condition being satisfied has been detected, obtaining a trained policy network, so as to adjust hedging portfolios of financial derivatives on the basis of the policy network.

IPC Classes  ?

• G06Q 40/04 - Trading Exchange, e.g. stocks, commodities, derivatives or currency exchange

Abstract

Methods for treating a cytokine storm in a subject in need thereof, the method comprising: administering a therapeutically effective amount of a therapeutic selected from the group consisting of (+)-(S)-2-(6-methoxynaphthalen-2-yl) propanoic acid, acetylsalicylic acid, dexamethasone, azathioprine and pharmaceutically acceptable salts thereof to the subject, wherein the cytokine storm is associated with an Acinetobacter baumannii infection in the subject.

IPC Classes  ?

• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 37/06 - Immunosuppressants, e.g. drugs for graft rejection

Abstract

Carbon footprint optimization of an electric vehicle, such as a heavy-duty e-truck, traveling in a trip across a highway network subject to a hard deadline constraint and one or more battery state-of-charge (SoC) constraints is carried out by co-determining a route plan, a speed plan and an intermediary charging plan for the electric vehicle with an objective of minimizing a carbon footprint incurred in the trip. In co-determining the three plans, a stage-expanded graph for modeling possible routing decisions of routing the trip in the highway network and possible charging decisions of charging the electric vehicle during the trip is constructed. The stage-expanded graph embeds information of arrival time and arrival SoC to facilitate modeling the charging decisions. The three plans are optimized by a dual subgradient method according to the stage-expanded graph under the objective of minimizing the carbon footprint while satisfying the constraints.

IPC Classes  ?

• G01C 21/34 - Route searchingRoute guidance

Abstract

An image processing framework for multi-class classifying a subject into cognitive normal, mild cognitive impairment and Alzheimer's disease (AD) conditions is developed. In one realization of the framework, an AD_Net model, which is an attention-enhanced convolution neural network (CNN) formed by embedding a Convolutional Block Attention Module (CBAM) into a CNN having a Visual Geometry Group 19 (VGG19) architecture, processes an image volume of the subject's brain to generate a plurality of AD_Net feature maps and a first plurality of scores that predict respective likelihoods of the three conditions. To enhance the prediction accuracy, a multilayer perception model formed with a plurality of fully connected layers processes the plurality of AD_Net feature maps and a plurality of influencing factors of AD, such as age, gender, geriatric depression scale score, Mini-Mental State Examination score and clinical dementia rating score, to generate a second plurality of scores that predict the respective likelihoods.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
• G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

Disclosed is a novel compound 5-(3,4-difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263, Compound 1), its derivatives, composition comprising the compound and method to effectively relieve nerve injury-induced neuropathic pain. Also disclosed are methods of treating diseases or disorders associated with the voltage-gated sodium channels. The disclosed methods may be utilized to treat diseases or disorders associated with pain in a subject, including nociceptive pain, chronic pain, neuropathic pain, and inflammatory pain. Also disclosed are inhibitors that specifically inhibit voltage-gated sodium channel function in a state-dependent manner. The disclosed compounds may also be used in pharmaceutical compositions and methods for treatment of pain associated with voltage-gated sodium channel activity.

IPC Classes  ?

• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61K 31/4245 - Oxadiazoles
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

A method of preparing hierarchical core-satellite particles, the method comprising: contacting charged microparticles comprising a first charge, charged nanoparticles comprising a second charge, and a charged binding material selected from the group consisting of charged small molecules and charged polymers, wherein the charged small molecules or the charged polymers comprise a third charge in a solvent thereby forming the hierarchical core-satellite particles, wherein the first charge and the second charge are both positively charged or negatively charged, the third charge is the opposite charge of the first charge and the second charge, and the average size of the charged microparticles is at least about 103 times larger than the average size of the charged nanoparticles.

IPC Classes  ?

• B01J 13/10 - Complex coacervation, i.e. interaction of oppositely charged particles
• B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons

Abstract

A method for isolating a circulating tumor cell (CTC) in a sample comprising the CTC or suspected of comprising the CTC, the method including: incubating the sample with immuno-microparticles thereby forming cell and microparticle aggregates (CPAs) in an incubation solution, wherein the average size of the CPAs is larger than 10 μm; and isolating the CPAs with a size-based isolation method thereby forming an isolated CTC, wherein the immuno-microparticles comprise one or more first antibodies conjugated to microparticles, wherein the one or more first antibodies specifically bind to one or more markers of the CTC.

IPC Classes  ?

• C12N 5/09 - Tumour cells
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving labelled substances
• G01N 21/64 - FluorescencePhosphorescence

Abstract

In cell instance segmentation of an original cell image obtained by microscopy, the original cell image is rotated by a rotation angle to yield a rotated cell image. A first machine-learning model for cell instance segmentation processes the original and rotated cell images such that effectively, horizontal and oblique boxes are used in bounding cells of the original cell image for enhancing cell-segmentation accuracy. A set of predictions is generated for each cell instance identified from the original and rotated cell images, yielding a plurality of sets of predictions for all cell instances. The plurality of sets of predictions is processed to remove any set having predicted space not simply connected, any unwanted set classified by a second machine-learning model as a poor indicator according to a certain performance criterion, and any redundant set. The plurality of sets of predictions then produces a segmentation map for the original cell image.

IPC Classes  ?

• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
• G06T 3/60 - Rotation of whole images or parts thereof
• G06T 7/12 - Edge-based segmentation
• G06V 10/25 - Determination of region of interest [ROI] or a volume of interest [VOI]
• G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
• G06V 10/771 - Feature selection, e.g. selecting representative features from a multi-dimensional feature space

Abstract

Ruthenium-iron nanoflower particles having a plurality of RuFe nanosheets, wherein the plurality of RuFe nanosheets are in a form of a nanoflower useful for the electrochemical synthesis of ammonia; an electrode including the RuFe nanoflower particles; and methods of preparation and use thereof.

IPC Classes  ?

• C25B 11/089 - Alloys
• C01C 1/02 - Preparation or separation of ammonia
• C01G 55/00 - Compounds of ruthenium, rhodium, palladium, osmium, iridium, or platinum
• C25B 1/27 - Ammonia
• C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof
• C25B 11/02 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form

Abstract

Method of reducing carbon dioxide to form one or more hydrocarbon products, the method comprising: providing an electrochemical cell comprising: a working electrode comprising a copper composite comprising a copper nanosheet array comprising a plurality of copper nanosheets, wherein the plurality of copper nanosheets comprise copper(100) facets; a counter electrode; optionally a reference electrode; and an electrolyte solution comprising an electrolyte and CO2, wherein the electrolyte solution is between and in contact with the working electrode, the counter electrode, and optionally the reference electrode; and applying an electric current between the working electrode and the counter electrode resulting in electrolytic reduction of the CO2 thereby forming the one or more hydrocarbon products.

IPC Classes  ?

• C25B 3/26 - Reduction of carbon dioxide
• C25B 3/03 - Acyclic or carbocyclic hydrocarbons
• C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof
• C25B 11/061 - Metal or alloy

Abstract

An AZB detection method for video coding, which includes the steps of detecting if a residual signal includes a spatial domain GAZB; detecting if the residual signal includes a frequency domain GAZB if no spatial domain GAZB is detected in the previous step; detecting if the residual signal includes a PAZB if no frequency domain GAZB is detected in the previous step; and determining that the residual signal is a non-AZB signal if no PAZB is detected in the previous step. The proposed method achieves promising time savings for test sequences of different resolutions, with negligible rate-distortion performance loss.

IPC Classes  ?

• H04N 19/176 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being an image region, e.g. an object the region being a block, e.g. a macroblock
• H04N 19/12 - Selection from among a plurality of transforms or standards, e.g. selection between discrete cosine transform [DCT] and sub-band transform or selection between H.263 and H.264
• H04N 19/124 - Quantisation
• H04N 19/147 - Data rate or code amount at the encoder output according to rate distortion criteria
• H04N 19/18 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using adaptive coding characterised by the coding unit, i.e. the structural portion or semantic portion of the video signal being the object or the subject of the adaptive coding the unit being a set of transform coefficients
• H04N 19/60 - Methods or arrangements for coding, decoding, compressing or decompressing digital video signals using transform coding

Abstract

A centimeter-resolution integrated photonic millimeter-wave (mmWave) radar chip operating in the mmWave V band based on a 4-inch wafer-scale thin-film lithium niobate (TFLN) technology is provided. The fabricated TFLN photonic mmWave integrated circuit has a first electro-optic modulator (EOM) capable of generating a broadband linear frequency modulated mmWave radar waveform through optical frequency multiplication of a low-frequency input signal, and a second EOM for frequency de-chirp of the reflected echo wave, thereby greatly relieving bandwidth requirements for the digital-to-analog converter in the transmitter and analog-to-digital converter in the receiver. In the absence of optical and electrical filters, the radar chip features continuous on-demand tunability of the center frequency and bandwidth, currently only limited by the bandwidths of electrical amplifiers. The radar chip provides a promising way to achieve high resolution sensing and detection for vehicle radar, airborne radar, and smart home in the 6G era.

IPC Classes  ?

• G01S 7/03 - Details of HF subsystems specially adapted therefor, e.g. common to transmitter and receiver
• G01S 7/35 - Details of non-pulse systems

Abstract

A wireless sensing method and systems based on compressed beamforming reports (CBR) are provided. The method includes performing channel sounding and transmit (TX) beamforming; performing sniffing or extracting information from Wi-Fi traffic; and performing multi-path estimation. The performing multi-path estimation includes performing multi-path modeling with CBR to analyze relationship between signal propagation characteristics and information in CBR by modeling a multi-path channel based on uplink and downlink steering matrices. The performing multi-path modeling with CBR includes performing multi-path modeling with CBR from physical paths to channel state information (CSI) and subsequently from CSI to CBR. The performing multi-path estimation further includes performing maximum likelihood multi-path estimation. The performing maximum likelihood multi-path estimation includes analyzing multi-path fingerprint in CBR, performing fingerprint matching, and performing maximum-likelihood estimation (MLE)-based multi-path reconstruction.

IPC Classes  ?

• H04B 7/06 - Diversity systemsMulti-antenna systems, i.e. transmission or reception using multiple antennas using two or more spaced independent antennas at the transmitting station
• H04L 25/02 - Baseband systems Details

Abstract

Method of treating a nerve injury in a subject in need thereof, the method comprising: administering a therapeutically effective amount of a therapeutic agent to the subject, wherein the therapeutic agent is selected from the group consisting of metaxalone and a Formin-2 inhibitor, such as an antibody, an antibody fragment, an inhibitory nucleic acid molecule, or a small molecule, wherein the inhibitory nucleic acid molecule substantially silences Fmn2.

IPC Classes  ?

• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 31/421 - 1,3-Oxazoles, e.g. pemoline, trimethadione
• A61P 25/02 - Drugs for disorders of the nervous system for peripheral neuropathies

Abstract

Provided are compositions comprising chemically synthesized pseudaminic acid (Pse) conjugated to a carrier protein using the OPA chemistry, methods of using said compositions to stimulate immune responses in subjects and protect the vaccinated subjects from infections caused by Pse-producing A. baumannii.

IPC Classes  ?

• A61K 39/104 - Pseudomonas
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 31/04 - Antibacterial agents

Abstract

The present invention provides an integrated system built on a microfluidics with multiple layers including a cell culture surface and different chambers configured to allow multiple cultivations of a biological agent, formation of three-dimensional multicellular culture model or biofilm, colonization and re-colonization of the biological agent responsive to a stimuli introduced to the integrated system. Such stimuli include physical, chemical and/or biological substance that may affect proliferation, differentiation, and/or function of the biological agent. The biological agent includes a biofilm-forming microbe such as a ubiquitous biofilm-forming bacterial species or biological cells or tissues of a different origin or species such as eukaryotic cells/tissues. The present integrated system can be used in drug screening, establishment of disease model in vitro or in vivo, evaluation of an anti-microbial efficacy, and studying cell-cell interaction.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• C12Q 1/18 - Testing for antimicrobial activity of a material

Abstract

An integrated system built on a microfluidics with multiple layers includes a cell culture surface and different chambers configured to allow multiple cultivations of a biological agent, formation of three-dimensional multicellular culture model or biofilm, colonization and re-colonization of the biological agent responsive to a stimuli introduced to the integrated system. Such stimuli include physical, chemical and/or biological substance that may affect proliferation, differentiation, and/or function of the biological agent. The biological agent includes a biofilm-forming microbe such as a ubiquitous biofilm-forming bacterial species or biological cells or tissues of a different origin or species such as eukaryotic cells/tissues. The integrated system can be used in drug screening, establishment of disease model in vitro or in vivo, evaluation of an anti-microbial efficacy, and studying cell-cell interaction.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• A61P 31/04 - Antibacterial agents

Abstract

Methods and systems for pre-processing immunocytochemistry images for machine learning are provided. The pre-processing method includes receiving paired positive and negative multi-protein images and segmenting stains of the paired multi-protein images. The method also includes labelling each image pixel corresponding to a cell of the paired multi-protein images and translating image pixel information of the labelled image pixels to tabular form to generate a table of cell coordinates and geometrical characteristics for each of the paired multi-protein images. The method further includes generating two cell-paired tables for each of the paired multi-protein images based on Euclidean distance-based pairing prior to input for the machine learning, where the Euclidean distance-based pairing is based on the cell coordinates in the table of cell coordinates and geometrical characteristics for each of the paired multi-protein images.

IPC Classes  ?

• G06T 7/11 - Region-based segmentation
• G06T 7/00 - Image analysis

Abstract

Organic-inorganic hybrid perovskite including: M2+, one or more A+, and a multifunctional nonvolatile additive (MNA) comprising a cationic species having the formula R1Ar1R2, wherein M2+ comprises Pb2+, Sn2+, Ge2+, or a mixture thereof; each of the one or more A+ is independently selected from the group consisting of Cs+, Rb+, CH3NH3+, CH3CH2NH3+, H(C═NH2)NH2+, and Me(C═NH2)NH2+; Ar1 is an optionally substituted aryl or an optionally substituted heteroaryl; R1 is —COOH, —CH2COOH, —CH2CH2COOH, —SO3H, —CH2SO3H, —CH2CH2SO3H, —PO3H2, —CH2PO3H2, or —CH2CH2PO3H2; and R2 is —NH(C═NH2)NH2+ or —N(R)3H+, wherein R for each instance is independently hydrogen or C1-C6 alkyl, with the proviso that the one or more A+ includes H(C═NH2)NH2+.

IPC Classes  ?

• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

Method of at least partially inhibiting the function of Klebsiella pneumoniae carbapenemase-2 (KPC-2) or a variant thereof, the method including contacting the KPC-2 with a benzoxaborole selected from the group consisting of 5-chloro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole, and mixtures thereof useful in the treatment of beta-lactam antibiotic resistant bacteria infections in a subject.

IPC Classes  ?

• A61K 31/69 - Boron compounds
• A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
• A61P 31/04 - Antibacterial agents

Abstract

There is provided a robot comprising an aerial unit, a passive leg mechanism operably coupled with the aerial unit, and a controller. The controller is configured to control operation of the aerial unit such that the robot is operable in, at least, a flight mode and a hopping mode.

IPC Classes  ?

• B60F 5/02 - Other vehicles capable of travelling in or on different media convertible into aircraft
• B64U 10/14 - Flying platforms with four distinct rotor axes, e.g. quadcopters
• B64C 1/00 - FuselagesConstructional features common to fuselages, wings, stabilising surfaces or the like

Abstract

A sweat extraction and monitoring system comprises a triboelectric nanogenerator (TENG) for inducing localized sweating for a human skin to generate sweat, iontophoresis electrodes electrically connected to the TENG and configured to be operably electrically contacting the human skin, at least one microfluidic channel for receiving the sweat, at least one biosensor for sensing the sweat received in the at least one microfluidic channel, and at least one sweat-activated battery configured to be actuatable by the sweat for powering the at least one biosensor.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• H02N 1/04 - Friction generators

Abstract

Ternary heterostructure comprising Ni2P, MoNiP2, and MoP, wherein the ternary heterostructure comprises crystalline regions and amorphous regions useful as an electrocatalyst for alkaline hydrogen evolution reaction; a cathode and an electrochemical cell including the same; and methods of preparation and use thereof.

IPC Classes  ?

• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C01B 25/08 - Other phosphides
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 11/037 - Electrodes made of particles
• C25B 11/061 - Metal or alloy

Abstract

Similarity-based deformable registration of medical images that contain tumor regions often undesirably leads to disproportionate volume changes to tumor regions. An image-registration framework for preserving tumor volumes while promoting similarity in non-tumor part is provided. The framework involves a two-stage process. In the first stage, similarity-based registration is used to identify potential tumor regions by their volume change, generating a soft tumor mask accordingly. In the second stage, a volume-preserving registration network is used. The network uses a novel adaptive volume-preserving loss that penalizes the change in size adaptively based on the masks calculated from the previous stage. The framework balances image similarity and volume preservation in different regions, i.e. non-tumor and tumor regions, by using soft tumor masks to adjust the imposition of volume-preserving loss on each one. It ensures that the tumor volumes are preserved during the registration process.

IPC Classes  ?

• G06T 3/00 - Geometric image transformations in the plane of the image
• G06T 7/00 - Image analysis
• G06T 7/30 - Determination of transform parameters for the alignment of images, i.e. image registration
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume

Abstract

A general method for synthesizing a series of novel amorphous-crystalline palladium (Pd) -based heterophase nanocatalysts for various promising electrocatalytic applications. The synthesized amorphous-crystalline Pd-PdAu core-island nanocatalyst exhibits high activity, fast reaction kinetics, and excellent long-term catalytic stability toward glycerol oxidation reaction (GOR). Remarkably, the main product of glycerol catalyzed by amorphous-crystalline Pd-PdAu core-island heterostructure is glyceric acid, which possesses the highest commercial value among all the GOR products. The one-pot synthesized amorphous-crystalline Pd-PdPt Janus heterostructure shows remarkable catalytic activity, and fast reaction kinetics towards formic acid oxidation reaction (FOR) in alkaline solution in comparison with commercial Pt/C catalyst and amorphous Pd nanoparticles (NPs), which benefits the development of advanced electrocatalysts for practical applications. The synthesized amorphous-crystalline PdCu Janus heterostructures with bcc phase exhibit high activity, fast reaction kinetics, and excellent long-term catalytic stability for hydrogen evolution reaction (HER) and 5-hydroxymethylfurfural oxidation reaction (HMFOR), benefiting the development of advanced electrocatalysts for practical applications.

IPC Classes  ?

• B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions

Abstract

The present invention provides a photoelectrochemical (PEC) cell and a lithium extraction device based on same. The PEC cell comprises: a substrate having a first surface and a second surface opposite to the first surface; a photo-absorber disposed on the first surface of the substrate; a protective layer disposed on the second surface of the substrate; and a catalyst layer disposed on the protective layer. The photo-absorber is spatially and functionally decoupled from the catalyst layer through the substrate to avoid the blocking of light to be absorbed by the photo-absorber caused by the shadowing effect of co-catalysts or gas products before it reaches the photo-absorber. Combining the decoupled PEC cell and Li-ion selective membrane, high-purity green Li is successfully extracted from seawater for the first time while storing solar energy as hydrogen energy with high efficiency.

IPC Classes  ?

• B01J 19/08 - Processes employing the direct application of electric or wave energy, or particle radiationApparatus therefor
• H01L 31/0224 - Electrodes
• H01L 31/0256 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by the material
• H01L 31/0735 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof adapted as photovoltaic [PV] conversion devices characterised by at least one potential-jump barrier or surface barrier the potential barriers being only of the PN heterojunction type comprising only AIIIBV compound semiconductors, e.g. GaAs/AlGaAs or InP/GaInAs solar cells
• C25B 1/26 - ChlorineCompounds thereof

Abstract

The present invention relates to a method for preparing polymer film, comprising the following steps: i) forming at least one polymer as a first membrane by electrospinning; ii) forming a first mixture by dispersing at least one mid-infrared radiation reflective material into a first liquid; iii) filtering said first mixture, wherein said first membrane is used as a filter membrane, thereby depositing said at least one mid-infrared radiation reflective material on said first membrane to form a second membrane, and iv) drying said second membrane to form a third membrane; characterized in that, said at least one polymer is selected from polyvinylidene fluoride and/or polyurethane.

IPC Classes  ?

• C08J 5/18 - Manufacture of films or sheets
• C08K 3/14 - Carbides
• D01D 5/00 - Formation of filaments, threads, or the like
• D01F 6/12 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolymers obtained by reactions only involving carbon-to-carbon unsaturated bonds from polymers of halogenated hydrocarbons from polymers of fluorinated hydrocarbons
• D01F 6/70 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from homopolycondensation products from polyurethanes
• D04H 1/413 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties containing granules other than absorbent substances
• D04H 1/4318 - Fluorine series
• D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
• D06M 11/74 - Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbon or graphiteTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with carbidesTreating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereofSuch treatment combined with mechanical treatment, e.g. mercerising with carbon or compounds thereof with graphitic acids or their salts
• D06M 101/22 - Polymers or copolymers of halogenated mono-olefins

Abstract

A method for solving multiple OPF equations of an AC electrical power system with plural topologies and admittances is provided. The method includes determining a continuous admittance space to embed the plural topologies, determining a plurality of voltage magnitudes and a plurality of voltage phase angles of the plurality of buses by a deep neural network, and reconstructing an active power generation and a reactive power generation using power flow equations according to the plurality of voltage magnitudes, the plurality of voltage phase angles, and the load inputs. The continuous admittance space is an admittance matrix of a plurality of line admittances each having a default admittance computed using a conductance and a susceptance of the plurality of branches. The deep neural network receives the load inputs and the plurality of line admittances as inputs.

IPC Classes  ?

• H02J 3/16 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by adjustment of reactive power

Abstract

There is provided a method for autoregressive based compression of a dataset with a plurality of data units, comprising using a neural network based probability estimator, determining a probability associated with a target data unit based on one or more previous data units associated with the target data unit, and using a coder, coding the target data unit based on the target data unit and the determined probability associated with the target data unit.

IPC Classes  ?

• H03M 7/30 - CompressionExpansionSuppression of unnecessary data, e.g. redundancy reduction

Abstract

222- related conversion techniques. The 2H Au nanomaterials possess unique optical properties compared with their 3C counterparts. The lifetime of plasmonic hot carriers in 2H Au square nanosheets is much longer than that in 3C Au square nanosheets, indicating 2H Au square nanosheets may be promising materials for optoelectronic applications.

IPC Classes  ?

• B22F 1/054 - Nanosized particles

Abstract

A microfluidic device (10), comprising a blood sample inlet (12), a separation membrane (14), a manifold inlet (16) in fluid communication with the blood sample inlet (12) at a joint (18), a capillary pump (22) in fluid communication with the joint (18) and located downstream of the joint (18), and a vent hole (24) in fluid communication with the capillary pump (22). The separation membrane (14) comprises a top layer (28) adjacent to the sample inlet (12) and a bottom layer (30) distant from the sample inlet (12). The top layer (28) has an average pore size ranging from about 1 μm to about 50 μm. The bottom layer (30) has an average pore size ranging from about 0.05 μm to about 20 μm. The separation membrane (14) is arranged between the blood sample inlet (12) and the joint (18).

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A shape memory ceramic is provided. The shape memory ceramic comprises a first portion and a second portion. The first and second portions of the shape memory ceramic are bonded, and the shape memory ceramic is elastomer-derived ceramic comprising silicon oxycarbide. The first portion of the shape memory ceramic is treated with ultraviolet ozone, and the second portion of the shape memory ceramic is free from treatment of ultraviolet ozone. The manufacturing and 4D printing methods of the shape memory ceramic are also provided.

IPC Classes  ?

• B29C 64/135 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 10/00 - Processes of additive manufacturing
• C04B 35/00 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products

Abstract

The present invention relates to the field of chemical and pharmaceutical technologies, in particular to a polypeptide and its use as a CCK receptor agonist/antagonist. Experiments show that the polypeptide provided by the present invention has a high agonistic/antagonistic activity on CCK receptors. Compared with the polypeptide CCK4, the polypeptide according to the present invention has a longer half-life and duration of efficacy in vivo. Experiments show that the polypeptide according to the present invention produces a significant improvement on the spatial memory deficiency of senile mice, memory-deficient senile mice, and Alzheimer's mice, and thus has a great application potential.

IPC Classes  ?

• A61K 38/07 - Tetrapeptides
• C07K 5/117 - Tetrapeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp

Abstract

Viral protease, EV71 2A proand SARS-CoV-2 3CL pro, promote the extracellular level of LRPAP1, which degrades IFNAR1 and inhibits the following interferon signaling. Moreover, inhibiting LRPAP1 by a composition having α2M, siRNA, or other LRPAP1 inhibitors can improve both RNA and DNA viral infections.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 31/14 - Antivirals for RNA viruses
• A61P 31/20 - Antivirals for DNA viruses
• A61P 31/22 - Antivirals for DNA viruses for herpes viruses

Abstract

A reversible phase transition in the whole semimetallic 1T′-tungsten disulfide (1T′-WS2) is realizable by proton intercalation and deintercalation, resulting in a newly-discovered semiconducting WS2 with a novel unconventional phase, denoted as 1T′d phase. A transport modulation with an on/off ratio of over 106 is realizable during the phase transition from the 1T′-WS2 to 1T′d-WS2. A transistor utilizing the advantage of reversible phase transition is developed by using a 1T′-WS2 nanosheet as a channel layer. A proton electrolyte contacts an edged circumference of the nanosheet for providing a reservoir of protons for proton intercalation and deintercalation of the nanosheet. The proton electrolyte is controllable by a gate-source voltage to intercalate or de-intercalate the nanosheet with protons for inducing a reversible phase transition over the nanosheet to thereby modify an electrical conductance of the channel layer or a spectral response of the channel layer to light.

IPC Classes  ?

• H10N 70/00 - Solid-state devices having no potential barriers, and specially adapted for rectifying, amplifying, oscillating or switching
• H10N 70/20 - Multistable switching devices, e.g. memristors

Abstract

An integrated MWP processing engine based on a thin-film lithium niobate (LN) platform capable of performing computation tasks of analog signals up to 92G samples per second is provided. By integrating a high-speed electro-optic modulation block and a multi-purpose low-loss signal processing section on the same chip fabricated from a 4-inch wafer-scale process, we demonstrate high-speed analog computation, i.e. first- and second-order temporal integration and differentiation with computing accuracies up to 98.1%, and deploy these functions to showcase three proof-of-concept applications, namely, ordinary differential equation solving, ultra-wideband signal generation and high-speed edge detection of images. We further leverage the image edge detector to enable a photonic-assisted image segmentation model that effectively outlines boundaries of melanoma lesion in medical images, achieving orders of magnitude faster processing speed and lower power consumption than conventional electronic processors. Our ultrafast LN MWP engine provides compact, low-power, low-latency and cost-effective solutions.

IPC Classes  ?

• H04B 10/54 - Intensity modulation
• G02F 1/21 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference
• G02F 1/225 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour by interference in an optical waveguide structure

Abstract

The present disclosure provides a LAMP-based, one-pot pathogen detection system and method integrating a high specificity assay for identifying true positive samples in an analyte before a whole course of LAMP reaction completes, in order to shorten the reaction time and reduce the likelihood of false positive results due to non-specific amplification or signal error (e.g., sample has too high pH) in the LAMP reaction. The present invention integrates an immunochromatographic assay such as lateral flow assay (LFA) in result interpretation from colorimetric and/or fluorimetric aspects of the LAMP reaction in order to enable a real-time pathogen detection, thereby improving the efficiency thereof with high specificity. The present detection system employs a single reaction system to enable multiple result interpretation, and the LAMP reaction can be carried out in a simple platform capable of generating constant heat.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

Methods of treating a hypervirulent Klebsiella pneumoniae (hvKp) infection in a subject in need thereof, the method involving co-administering a therapeutically effective amount of an antibiotic and a non-steroidal anti-inflammatory drug or a signal transducer and activator of transcription 1 inhibitor to the subject.

IPC Classes  ?

• A61K 31/616 - Salicylic acidDerivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
• A61K 31/341 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
• A61K 31/353 - 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• A61K 31/52 - Purines, e.g. adenine
• A61K 31/545 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
• A61P 31/04 - Antibacterial agents

Abstract

Electrocatalytic overall water splitting to generate hydrogen and oxygen is a green and sustainable approach with zero carbon emission, which is important for the future renewable energy landscape. The practical application of this approach is challenging due to the sluggish reaction kinetics of water activation at high current densities, which are hard to overcome. Although high-performance alkaline bifunctional electrocatalysts may be useful, current catalysts lack both activity and durability. One approach is to rationally design bifunctional two-dimensional (2D) heterostructures but obtaining an efficient and durable catalyst has proved difficult. The present disclosure relates generally to an electrocatalyst including a 2D heterostructure (Ru-CMOP), methods of making and using the same. The catalyst of the present disclosure is designed for high activity and good durability at industrial-level high current densities.

IPC Classes  ?

• C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
• C25B 9/17 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof
• C25B 11/054 - Electrodes comprising electrocatalysts supported on a carrier
• C25B 11/061 - Metal or alloy
• C25B 11/065 - Carbon

Abstract

Continuous miniaturization of semiconductor devices is the key to boosting modern electronics development. However, such downscaling strategy has been rarely utilized in photoelectronics and photovoltaics. Here, in this work, a full-vdWs 1D p-Te/2D n-Bi2O2Se heterodiode with a rationally-designed nanoscale ultra-photosensitive channel is reported. Enabled by the dangling bond-free mixed-dimensional vdWs integration, the Te/Bi2O2Se type-II diodes show a high rectification ratio of 3.6×104. Operating with 100 mV reverse bias or in a self-power mode, the photodiodes demonstrated excellent photodetection performances, including high responsivities of 130 A W−1 (100 mV bias) and 768.8 mA W−1 (self-power mode), surpassing most of the reports of other heterostructures. More importantly, a superlinear photoelectric conversion phenomenon is uncovered in these nanoscale full-vdWs photodiodes, in which a model based on the in-gap trap-assisted recombination is proposed for this superlinearity. All these results provide valuable insights in light-matter interactions for further performance enhancement of photoelectronic devices.

IPC Classes  ?

• H01L 31/109 - Devices sensitive to infrared, visible or ultraviolet radiation characterised by only one potential barrier or surface barrier the potential barrier being of the PN heterojunction type
• H01L 31/0336 - Inorganic materials including, apart from doping materials or other impurities, semiconductor materials provided for in two or more of groups in different semiconductor regions, e.g. Cu2X/CdX hetero-junctions, X being an element of Group VI of the Periodic System
• H01L 31/0352 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by their semiconductor bodies characterised by their shape or by the shapes, relative sizes or disposition of the semiconductor regions
• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

The present invention discloses a method for preparing a polyurethane film, comprising the steps of: i) dissolving polyurethane into a first solvent to form a first solution; ii) dissolving salt into a second solvent to form a second solution; iii) preparing a spinning stock solution by mixing said first solution and said second solution; iv) spinning said spinning stock solution in an electrospinning device to obtain a polyurethane film; v) providing a container to which a third solvent is sprayed; and vi) arranging said polyurethane film in said container for a period of time.

IPC Classes  ?

• D01D 5/00 - Formation of filaments, threads, or the like
• C08G 18/42 - Polycondensates having carboxylic or carbonic ester groups in the main chain

Abstract

A method for preparing a polyurethane film, comprising the steps of: i) dissolving polyurethane into a first solvent to form a first solution; ii) dissolving salt into a second solvent to form a second solution; iii) preparing a spinning stock solution by mixing said first solution and said second solution; iv) spinning said spinning stock solution in an electrospinning device to obtain a polyurethane film; v) providing a container to which a third solvent is sprayed; and vi) arranging said polyurethane film in said container for a period of time.

IPC Classes  ?

• D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
• D04H 1/4382 - Stretched reticular film fibresComposite fibresMixed fibresUltrafine fibresFibres for artificial leather
• D01D 5/00 - Formation of filaments, threads, or the like

Abstract

A weakly-supervised framework for segmenting a three-dimensional (3D) medical image incorporates information of geometric prior and contrastive similarity in a loss-based fashion for enhancing distinguishability of an organ in presence of complex organ shape and image artifacts (e.g., low-contrast tissues) in the image. Training images with bounding-box annotations are used to train the framework. The geometric prior is advantageously built on point-cloud representations, which are much more fine-grained and flexible than volume representations, thus serving as better supervision than an inherent property of the bounding-box annotations (i.e. height and width). Furthermore, using contrastive similarity encourages organ pixels to gather around in a contrastive embedding space. It helps more-effectively distinguish low-contrast tissues from the background than using the conventionally-used gray space.

IPC Classes  ?

• G06T 7/194 - SegmentationEdge detection involving foreground-background segmentation
• G06N 3/045 - Combinations of networks
• G06T 7/00 - Image analysis

Abstract

One embodiment includes a microfluidic chip for implementing cell deformability. The microfluidic chip comprises an inlet configured to receive cells, an outlet configured to output the cells, a plurality of main channels, and one or more bypass channels. The main channels are disposed between the inlet and the outlet and are provided with microconstrictions that are parallelized such that images of the cells are captured within a single field of view (FOV) when the cells pass through the microconstrictions and are deformed therein. The one or more bypass channels are independent from the main channels, thereby stabilizing pressure drop between the inlet and the outlet.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

Electrochemical conversion of nitrate to ammonia is an approach to alleviate nitrate pollution in water and simultaneously generate green NH3 fuels. The practical application of this approach is challenging due to the lack of efficient electrocatalysts. The present disclosure relates generally to an electrocatalyst including a plurality of CuWO4 hollow nanospheres, which include asymmetric oxygen vacancies and adjacent Mo clusters, and methods of making and using the same. The electrocatalyst of the present disclosure is designed for efficient ammonia electrosynthesis.

IPC Classes  ?

• C25B 11/091 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds
• C25B 11/02 - ElectrodesManufacture thereof not otherwise provided for characterised by shape or form
• C25B 11/052 - Electrodes comprising one or more electrocatalytic coatings on a substrate

Abstract

The present invention relates to a method for preparing a polymer film, comprising the following steps: preparing a polymer film with a polymer solution prepared from PVDF and/or TPU; preparing a mixed solvent selected from a group consisting of dimethylformamide, dimethylacetamide, ethanol, water, or any combination thereof, wherein said mixed solvent is characterized by the solubility of said mixed solvent to the polymer selected for said polymer solution and/or the contact angle of said mixed solvent on said polymer film; wetting said polymer film with said mixed solvent; and subjecting the wet polymer film to thermal treatment under pressure.

IPC Classes  ?

• C08J 5/18 - Manufacture of films or sheets
• B29C 71/02 - Thermal after-treatment

Abstract

Provided is a method for preparing a polymer film, comprising the following steps: preparing a polymer film with a polymer solution prepared from PVDF and/or TPU; preparing a mixed solvent selected from a group consisting of dimethylformamide, dimethylacetamide, ethanol, water, or any combination thereof, wherein said mixed solvent is characterized by the solubility of said mixed solvent to the polymer selected for said polymer solution and/or the contact angle of said mixed solvent on said polymer film; wetting said polymer film with said mixed solvent; and subjecting the wet polymer film to thermal treatment under pressure.

IPC Classes  ?

• D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
• D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
• D04H 1/54 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties by welding together the fibres, e.g. by partially melting or dissolving
• D04H 1/541 - Composite fibres e.g. sheath-core, sea-island or side-by-sideMixed fibres

Abstract

The present invention provides an integrated microfluidic-based device for establishing a wound infection in vivo model suitable for high throughput bioassay such as potential drug screening, in vivo dosing optimization, host-microbe or microbe-microbe interactions under the influence of specific agents of interest, and studying regulatory mechanisms of certain inflammatory diseases relating to or arising from the wound infection. The present invention allows direct qualitative and quantitative assessments of specific markers expressed due to the wound infection by one or more microbes devoid of cell sorting, isolation, or labelling as in other conventional in vivo models or methods.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

A single vessel multi-zone bioreactor for simultaneously culturing multiple microbial strains comprising multiple culturing zones arranged sequentially, each culturing zone comprising a porous hydrogel, and the use thereof for producing optionally encapsulated probiotics.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12N 1/20 - BacteriaCulture media therefor

Abstract

A framework that comprises a reinforcement-learning-based neural-network for compressing, and for transmitting the compressed genomes over a data network in repeated steps each of a plurality of species. The framework also takes data on inefficient transmission of compressed genome in the preceding step, and feeds this data forward to modify the selection of the compression parameter in the present step. The invention provides the possibility that the genome of any species may be compressed optimally and transmitted in optimal efficiency. That is, big genome sequence is neither over compressed, which takes a lot of processing time leading to delays, nor under compressed which will require more time to transmit.

IPC Classes  ?

• G16B 20/30 - Detection of binding sites or motifs

Abstract

A microfluidic device for visual quantification and determining of one or more material particles in a solution of material particles. The microfluidic device comprises: an inlet for receiving a solution, and a trap which is in fluid communication with the inlet and traps one or more material particles in the solution of material particles. The solution of material particles may be a sample solution received at the inlet or a treated solution obtained by post-treating the sample solution received at the inlet. The trap comprises a fluid channel, so that the presence and/or amount of one or more trapped material particles are determined in a visual form. The present invention further describes a method for using the device.

IPC Classes  ?

• G01N 15/10 - Investigating individual particles

Abstract

The present invention provides an integrated sweat sensing system including a multi-layered structure incorporating a flexible circuitry sensing layer with multiple electronic and mechanical components responsible for sensing certain physiological changes of a user and giving feedback signals to the user when a detectable biological, chemical or physiological signal exceeds certain threshold. The system further includes a microfluidic based biosensing platform responsible for sensing changes in sweat component composition including ions, glucose and pH changes, and subsequently trigger feedback signal outputs from the flexible circuitry sensing layer to provide the user with a corresponding change-of-state signal. The present system is bendable and detachably mountable on various skin regions of the user.

IPC Classes  ?

• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/1477 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using chemical or electrochemical methods, e.g. by polarographic means non-invasive
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements

Abstract

Two-dimensional face presentation attacks are one of most notorious and pervasive face spoofing types, causing security issues to facial authentication systems. To tackle these issues, a cost-effective face anti-spoofing (FAS) system based on acoustic modality, named as Echo-FAS, is devised, which employs a crafted acoustic signal to probe the presented face. First, a large-scale, high-diversity, acoustic-based FAS database, named as Echo-Spoof, is built. Based upon Echo-Spoof, we design a two-branch framework combining global and local frequency features of the presented face to distinguish live vs. spoofing faces. Echo-FAS has the following merits: (1) it only needs one speaker and one microphone; (2) it can capture three-dimensional geometrical information of the presented face and achieve a remarkable FAS performance; and (3) it can be handily allied with RGB-based FAS models to mitigate the overfitting problem in the RGB modality and make the FAS model more accurate and robust.

IPC Classes  ?

• G06F 21/32 - User authentication using biometric data, e.g. fingerprints, iris scans or voiceprints
• G06F 18/10 - Pre-processingData cleansing
• G06F 18/2131 - Feature extraction, e.g. by transforming the feature spaceSummarisationMappings, e.g. subspace methods based on a transform domain processing, e.g. wavelet transform

Abstract

The present invention provides a biosensing system including a microfluidic-based biosensor designed for both point-of-care testing and a home-based assessment. A method for distinguishing a metastatic sample from a non-metastatic sample in-situ based on an observation of relative distribution of organisms in a biosensor of the present system in response to different test samples through a portable imaging device or an imaging module integrated into a smartphone or mobile device is also provided. Chemotactic preference of the organisms to a sample is quantified by using Raman spectroscopy to generate a profile of target analytes for determination of metastatic status and potential in a particular sample.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
• G01N 21/65 - Raman scattering

Abstract

One embodiment includes an electromagnetic device for generating a magnetic field in a workspace. The electromagnetic device includes an elongated sleeve defining a hollow space and having an external surface, a magnetic core, and an electric coil wounded onto the external surface of the elongated sleeve and configured to generate the magnetic field when energized. The magnetic core has a first end, a second end, and a middle portion that is disposed between the first end and the second end and received in the hollow space. The first end is provided with a core tip that is shaped substantially as a cone and has a cone radius greater than zero.

IPC Classes  ?

• H01H 47/00 - Circuit arrangements not adapted to a particular application of the relay and designed to obtain desired operating characteristics or to provide energising current
• B25J 7/00 - Micromanipulators
• B25J 15/06 - Gripping heads with vacuum or magnetic holding means
• H01F 7/06 - ElectromagnetsActuators including electromagnets
• H01F 7/20 - ElectromagnetsActuators including electromagnets without armatures

Abstract

The present invention relates to methods modifying cell surface markers of red blood cells (RBCs) and uses of the same. In particular, the method comprises contacting an RBC with a peptide in the presence of a ligase, under suitable conditions and for sufficient time to allow ligation of the peptide to the RBC to form an RBC-peptide conjugate. In one embodiment, the ligase is OaAEPI ligase. The RBC-peptide conjugate may be further contacted with an effector molecule under suitable conditions and for sufficient time for conjugation of the effector molecule to the RBC-peptide to form an RBC-peptide-effector molecule conjugate.

IPC Classes  ?

• C12N 5/078 - Cells from blood or from the immune system
• C12N 9/00 - Enzymes, e.g. ligases (6.)ProenzymesCompositions thereofProcesses for preparing, activating, inhibiting, separating, or purifying enzymes

Abstract

The present invention provides a platform for large-scale profiling of post-transcriptional molecular targets including microRNAs (miRNAs) and methylated messenger RNAs (such as m6A mRNAs) with subcellular spatial resolution in a tissue-wide scale. The present platform is capable of high-throughput isolation of intracellular molecules by contacting an array of functionalized nanoprobes with a target tissue sample for capturing the molecular targets, and the isolated molecular targets are in-situ analysed. The present invention also provides a spectrum barcoding system and related method for digitally quantifying the isolated molecular targets on the nanoprobes and mapping with an imprint of the tissue sample to provide a single-cell spatial coordinate and expression pattern of each of the molecular targets corresponding to different sub-regions of the tissue sample.

IPC Classes  ?

• C12Q 1/6841 - In situ hybridisation

Abstract

An integrated device for rapid detection of SARS-CoV-2 is disclosed. The integrated device includes a front-end system, a back-end system, and a microfluidic channel. The front-end system includes a detection region and a control region. The detection region and the control region have similar structures, each including an interdigital electrode and a graphene film. The microfluidic channel is arranged to cover the detection region so as to allow the interdigital electrode of the detection region to be exposed to the breath sample. The graphene film of the detection region has a surface resistance higher than that of the graphene film of the control region when the detection region is exposed to a selected virus. The back-end system is configured to detect and compare the surface resistance of the graphene films of the detection region and the control region for determining whether the selected virus is present in the breath sample.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• G01K 7/22 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a non-linear resistance, e.g. thermistor
• G01N 27/12 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon absorption of a fluidInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a solid body in dependence upon reaction with a fluid
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present invention provides a non-mediative approach to capture biological cells and initiate cell pairing and fusion in a microfluidic-based system with multiple channels configured in various dimensions and shapes in order to create a hydrodynamic platform incorporating a passive trapping mechanism to entrap the cells of interest from fluid flowing through the multiple channels and allow cell fusion with certain rheological deformation in the absence of any cell disruption while the whole cell pairing and fusion process is closely monitored by simple optical monitoring device.

IPC Classes  ?

• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12N 15/02 - Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion

Abstract

A molecular point-of-care testing (POCT) diagnostic device for molecular detection of various diseases with “sample-in-result-out” principle is provided. The device has a sample tube in which a test sample is mixed with a sample buffer, a microfluidic-based reaction tube with a simple flow-based system for amplifying the sample buffer mixed with the test sample to form an amplified result, and a closed-system, disposable result interpretation using colorimetric- or lateral flow assay-based for assaying the amplified result. The device is portable and simple to use, which can help bring laboratory detection to the field.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers

Abstract

An eco-tile useful for promoting the growth of fauna and flora in an aquatic environment, the eco-tile including at least one type of cement; aggregates comprising at least two fine aggregates and coarse aggregates; and milled incineration sewage sludge ashes, wherein the at least two fine aggregates comprise dredged marine sediment, eco-concrete precursors thereof, and methods of use and preparation of the same.

IPC Classes  ?

• C04B 28/04 - Portland cements
• C04B 18/04 - Waste materialsRefuse
• C04B 18/10 - Burned refuse
• C04B 14/06 - QuartzSand
• C04B 20/00 - Use of materials as fillers for mortars, concrete or artificial stone according to more than one of groups and characterised by shape or grain distributionTreatment of materials according to more than one of the groups specially adapted to enhance their filling properties in mortars, concrete or artificial stoneExpanding or defibrillating materials
• C04B 24/20 - Sulfonated aromatic compounds
• C04B 28/28 - Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing organic polyacids, e.g. polycarboxylate cements
• C04B 24/26 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

A radiative cooling material for facilitating cooling of a wearable electronic device. The radiative cooling material includes a polymeric matrix and one or more materials dispersed in the polymeric matrix. The radiative cooling material is operable to facilitate reflection of solar radiation in at least some solar spectrum wavelengths, when the radiative cooling material is exposed to solar radiation. The radiative cooling material is also operable to facilitate emission of thermal radiation in at least some infrared spectrum wavelengths.

IPC Classes  ?

• C08L 83/04 - Polysiloxanes

Abstract

The present invention provides an implantable electrostimulation-based drug delivery system incorporating microneedle-based drug delivery module connecting with a wirelessly-controlled electrostimulation module such that under a small input power generated by magnetic coupling between a transmission antenna and a harvester of the wirelessly-controlled electrostimulation module, one or more substances stored in the microneedles can be released to tissues of a target site while no subsequent removal of the system from the target site is required as the system is entirely biodegradable and bioresorbable in vivo after a sufficient period of time.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A single-atomically dispersed metal/two-dimensional transition-metal dichalcogenide nanosheet hybrid comprising a plurality of single-atomically dispersed metal atoms disposed on at least one surface of a transition-metal dichalcogenide nanosheet, wherein the transition-metal dichalcogenide nanosheet is uniformly crystalline.

IPC Classes  ?

• C25B 11/093 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of at least one catalytic element and at least one catalytic compoundElectrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of two or more catalytic elements or catalytic compounds at least one noble metal or noble metal oxide and at least one non-noble metal oxide
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water

Abstract

The present disclosure relates to a method of flocculation, wherein harmful cyanobacteria are flocculated via metal-organic framework, and wherein the metal-organic framework comprises chromium, which is environmentally friendly. Water-stable Cr(III)-based MOFs, structured as NH2-MIL-101, remove harmful algal blooms, such as Microcystis aeruginosa, from natural water sources by promoting flocculation. NH2-MIL-101(Cr) MOFs efficiently remove harmful algae from water without creating secondary pollution and without causing the harmful algae to release intracellular toxins.

IPC Classes  ?

• C02F 1/52 - Treatment of water, waste water, or sewage by flocculation or precipitation of suspended impurities
• C07F 11/00 - Compounds containing elements of Groups 6 or 16 of the Periodic Table

Abstract

Klebsiella pneumoniae.

IPC Classes  ?

• A61K 31/7072 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/04 - Antibacterial agents

Abstract

Provided are a hydrogel-based cell encapsulation method, a cell-encapsulating polymerized microgel prepared therefrom, and a kit thereof. The hydrogel-based cell encapsulation method can include: (a) providing a cell suspension as an aqueous phase comprising cells, alginate and a culture medium; (b) preparing an emulsion using the cell suspension and an oil phase through a droplet microfluidic device such that one or more of the cells are each encapsulated in at least a portion of the droplets thereby forming an emulsion comprising cell-encapsulating droplets and empty droplets; (c) incubating the emulsion, and then cross-linking alginate in the cell-encapsulating droplets in the presence of a cross-linker to form cell-encapsulating polymerized microgels; and (d) optionally, demulsifying, separating and collecting the cell-encapsulating polymerized microgels.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 11/04 - Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres

Abstract

The present invention provides an electricity-driven, micro-electroporation based drug delivery system, in particular, an electrically conductive array of microprotrusions containing intended substances or molecules to be delivered, which is to the benefit of a recipient receiving vaccination transcutaneously in the absence of any assistive mechanical or actuation means as in conventional injection methods, so as to lower safety risks, improve immunization efficiency, and also induce immune response of the recipient more effectively at a relatively lower dose of vaccines.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
• B29C 39/02 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor for making articles of definite length, i.e. discrete articles
• B29C 39/00 - Shaping by casting, i.e. introducing the moulding material into a mould or between confining surfaces without significant moulding pressureApparatus therefor

Abstract

Provided is a confined migration microfluidic device for cell culture and drug screening, including a chip including a plurality of parallel channels, where each pair of it is connected through a plurality of the confined migration channels; a depth of the confined migration channel is lower than the first channel and second channel; a first/second inlet and a first/second outlet are provided at two ends of the first/second channel, respectively; and a pyramid-like structure for diverging flow to the first channels to ensure evenly distribution. During the usage, cells to be cultured are added into one of the first channel and the second channel, and drugs or cells which can influence confined migration of the target cells are added into the other channel; the inhibitory effect of the drugs or cells on the confined migration will be evaluated, thereby screening/studying effective drugs and cells in relation to the confined migration.

IPC Classes  ?

• C12M 3/06 - Tissue, human, animal or plant cell, or virus culture apparatus with filtration, ultrafiltration, inverse osmosis or dialysis means
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

The present disclosure provides a platform and method for predicting disease prognosis based on label-free liquid biopsy, in particular, to establish a disease model in vitro on a microfluidic device and provide a trained deep learning neural network for automatically extracting morphological features from cell clusters formed by the label-free liquid biopsy of a test subject in order to predict different disease stages and evaluate efficacies of a corresponding treatment regime to the test subject. The present disclosure also provides a method for training the neural network based on different cell cluster datasets obtained from the disease model corresponding to different deep learning models of the neural network.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 7/11 - Region-based segmentation
• G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts

Abstract

The present invention provides piezoelectric bio-organic films resembling ceramic-based piezoelectric films, and also a fabrication method thereof. In particular, the bio-organic piezoelectric films are formed by compact nanocrystals resembling the inorganic ceramic structure, where nanocrystallization on biomaterials and in-situ electric field are applied to facilitate domain orientation alignment across the entire films. The present fabrication method provides flexibility to tune various parameters of the resulting bio-organic films according to the needs, and therefore is substantially applicable to a wide range of biomaterials to form piezoelectric bio-organic films comparable to those formed by conventional piezoceramics in terms of piezoelectricity, thermostability and durability.

IPC Classes  ?

• C08J 5/18 - Manufacture of films or sheets
• B29C 41/00 - Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped articleApparatus therefor
• C08K 5/17 - AminesQuaternary ammonium compounds
• H01L 41/193 - Macromolecular compositions
• H01L 41/45 - Organic materials

Abstract

A nano scale robotic system for single cell DNA sequencing of a strand of DNA positioned on a slide utilizes an atomic force microscope (AFM) having an end effector in the form of a cantilever with a tip. The AFM causes its cantilever tip to scan over the base pairs of the DNA strand. A pair of spaced-apart electrodes at the tip makes contact with opposite sides of the DNA strand and the current between bases of the DNA strand is measured by a current measurement system connected to the electrodes. An artificial intelligence-based data analytic system determines the DNA sequence based on the current from the current measuring system. The AFM tip is guided over the DNA strand by comparing compressed desired intensity local scan images and compressed actual intensity local scan images and using the difference to control the location of the tip.

IPC Classes  ?

• G01Q 30/02 - Non-SPM analysing devices, e.g. SEM [Scanning Electron Microscope], spectrometer or optical microscope
• C12Q 1/6869 - Methods for sequencing
• C23C 14/16 - Metallic material, boron or silicon on metallic substrates or on substrates of boron or silicon
• C23C 14/30 - Vacuum evaporation by wave energy or particle radiation by electron bombardment
• C23C 14/34 - Sputtering
• C23C 14/58 - After-treatment
• C23C 16/04 - Coating on selected surface areas, e.g. using masks
• C23C 16/40 - Oxides
• C23C 16/56 - After-treatment
• G01Q 20/02 - Monitoring the movement or position of the probe by optical means
• G01Q 30/20 - Sample handling devices or methods
• G01Q 60/38 - Probes, their manufacture or their related instrumentation, e.g. holders
• G01Q 70/16 - Probe manufacture
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• G16B 40/20 - Supervised data analysis

Abstract

An electrotactile apparatus has an electrode-array unit and a driver unit for generating a haptic feedback to a user. The electrode-array unit uses electrodes to electro-stimulate the user's skin with pulsed voltage signals generated by the driver unit, inducing excitation currents flowing in the user to generate the haptic feedback. The driver unit is self-powered or wirelessly powered for supporting untethered electrotactile stimulation to the user. A common counter electrode installed on the driver unit contacts the user's skin and collects the excitation currents returned from the user. Advantageously, the common counter electrode is located on an outer surface of the driver unit and the driver unit is substantially flexible, facilitating the common counter electrode to seamlessly contact the user's skin for achieving a stable electrode-skin interface while positioning the driver unit as a whole on the user's skin to provide untethered virtual touching experience to the user.

IPC Classes  ?

• H04W 4/80 - Services using short range communication, e.g. near-field communication [NFC], radio-frequency identification [RFID] or low energy communication
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G06F 3/041 - Digitisers, e.g. for touch screens or touch pads, characterised by the transducing means
• H05K 1/02 - Printed circuits Details

Abstract

A photovoltaic cell comprising a perovskite layer (110), an electron transporting layer (106) and an interface layer (108) disposed between the electron transporting layer and the perovskite layer. The interface layer comprises a metallocene substituted with a substituent having an O, S, N or P group, for example ferrocene substituted with a thienyl-carboxylate group.

IPC Classes  ?

• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/85 - Layers having high electron mobility, e.g. electron-transporting layers or hole-blocking layers
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3

Abstract

The invention provides an enhanced electrospun film made from polyvinylidene fluoride (PVDF) and at least one low-melting-point polymer in a ratio of 99.9:0.1-90:10 by weight, and the low-melting-point polymer having a melting point lower than the polyvinylidene fluoride and a softening point in the range of 110-140 C°. The enhanced electrospun film exhibits excellent mechanical properties, higher moisture permeability and hydrostatic pressure resistance. The invention further provides a method for manufacturing the enhanced PVDF electrospun film, and use of the enhanced PVDF electrospun film in preparing a waterproof and moisture permeable product.

IPC Classes  ?

• D01D 5/00 - Formation of filaments, threads, or the like
• D01F 6/50 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polyalcohols, polyacetals or polyketals
• D01D 1/02 - Preparation of spinning solutions
• D01F 6/48 - Monocomponent man-made filaments or the like of synthetic polymersManufacture thereof from mixtures of polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds as major constituent with other polymers or low-molecular-weight compounds of polymers of halogenated hydrocarbons
• D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
• D04H 1/4318 - Fluorine series
• C08J 5/18 - Manufacture of films or sheets

Abstract

The present disclosure relates to a nanosensor for real-time monitoring of wound healing, a manufacturing method thereof, and a real-time monitoring system for wound healing using the same. A nanosensor according to example embodiments includes a biomarker for detecting mRNA and a reference gene on gold nanoparticles, thereby providing an objective indicator through monitoring of wound healing, enabling monitoring of wound healing through direct monitoring using real-time fluorescence by including a fluorescent marker in a nanoflare, and enabling evaluation of a whole wound healing process in normal and patient groups (diabetes) through real-time monitoring. In addition, the nanosensor according to the example embodiments has advantages of shortening synthesis time and improving efficiency by 30% through integration of a novel synthesis method (freezing method) rather than an existing synthesis method (salt aging).

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A method of managing real-time electrical energy storage management from an electricity storage device to maximise the reduction of the use of a mains electricity grid during peak cost charging periods on the mains electricity grid, including: calculating an ideal offline use of the electricity storage device using ideal predicted parameters; calculate a plurality of electrical storage device storage and electrical discharge models using a plurality of algorithms based on recorded data; calculate the competitive ratio for each of the algorithms and the ideal offline use; and use power from the electricity storage device based on an optimal competitive ratio.

IPC Classes  ?

• G06Q 50/06 - Energy or water supply
• H02J 3/14 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by switching loads on to, or off from, network, e.g. progressively balanced loading

Abstract

An enhanced PVDF electrospun film, which is prepared from polyvinylidene fluoride and at least one low-melting-point polymer having a melting point lower than that of polyvinylidene fluoride at a weight ratio of 99.9:0.1 to 90:10, wherein the softening point of the low-melting-point polymer is in the range of 110-140ºC. The enhanced electrospun film has good mechanical properties, a higher water vapor transmission rate, and hydrostatic pressure resistance. Further provided are a manufacturing method for the enhanced PVDF electrospun film and the use of the enhanced PVDF electrospun film in the preparation of a waterproof and moisture-permeable product.

IPC Classes  ?

• D04H 1/728 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres characterised by the method of forming fleeces or layers, e.g. reorientation of fibres the fibres being randomly arranged by electro-spinning
• D01F 8/06 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one polyolefin as constituent
• D01F 8/16 - Conjugated, i.e. bi- or multicomponent, man-made filaments or the likeManufacture thereof from synthetic polymers with at least one other macromolecular compound obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Abstract

The present invention provides a thermo-controlled smell generating device with an active cooling mechanism to allow a user thereof to control on/off of the device in a relatively short response time absent any temperature fluctuations even after a significant number of heating and cooling cycles. The present invention is ideal for generating olfaction in highly interactive or fast-changing environments such as virtual immersive environments.

IPC Classes  ?

• A61M 21/02 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer

Abstract

The present invention provides a surface tension assisted film forming method to prepare a flexible, patterned piezoceramic composite for use in a variety of electronics. The present method allows tuning mechanical and piezoelectric properties of the resulting composite by simply adjusting one or few parameters used during the piezoceramic film forming and/or composite forming procedures in the absence of any complex transferring techniques that are commonly used in conventional methods. The present invention also allows customizing patterns (two-dimensional or three-dimensional) on the piezoceramic framework to result in a piezoelectric composite that is able to provide anisotropic piezoelectric responses to different loads whilst still having a constant electrical output over a long-time deformation.

IPC Classes  ?

• H10N 30/092 - Forming composite materials
• H10N 30/045 - Treatments to modify a piezoelectric or electrostrictive property, e.g. polarisation characteristics, vibration characteristics or mode tuning by polarising
• H10N 30/06 - Forming electrodes or interconnections, e.g. leads or terminals
• H10N 30/078 - Forming of piezoelectric or electrostrictive parts or bodies on an electrical element or another base by depositing piezoelectric or electrostrictive layers, e.g. aerosol or screen printing by liquid phase deposition by sol-gel deposition
• H10N 30/85 - Piezoelectric or electrostrictive active materials
• H10N 30/87 - Electrodes or interconnections, e.g. leads or terminals

Abstract

A method of measuring RNA expression level of a target sequence in a sample is performed by simultaneously enriching the target sequence and corresponding RNA and calculating a RNA-to-DNA ratio of the same target sequence. A method of treating cancer includes the step of using the method of measuring RNA expression level of a target sequence. A kit includes components for performing the method of measuring RNA expression level of a target sequence.

IPC Classes  ?

• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

The present invention provides a device for improving energy economy and wearing comfort of a power generating, gait assisting footwear article while maintaining normal gait pattern during human locomotion. The device includes a motion conversion mechanism to convert linear reciprocating moment exerted on the device during heel strike/up into a series of rotations; a rotation acceleration module to increase the speed of rotations before being transformed into electric current by a generator. The device also includes a power management module and energy storage element(s) for energy storage and power supply to the footwear article or external electronics.

IPC Classes  ?

• A43B 7/32 - Footwear with health or hygienic arrangements with shock-absorbing means
• H02N 2/18 - Electric machines in general using piezoelectric effect, electrostriction or magnetostriction producing electrical output from mechanical input, e.g. generators

Abstract

Disclosed herein are methods of detecting the presence or absence of exosomes, the method comprising detecting an exosomal biomarker in a sample obtained from a subject. Also disclosed herein is a system and a biosensor, each for detecting an exosomal biomarker as disclosed herein.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

i being reduced as layers decrease such that L1 loss at higher layers has a higher weight than the L1 loss at lower layers.

IPC Classes  ?

• G06T 15/00 - 3D [Three Dimensional] image rendering
• G06N 3/045 - Combinations of networks
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods

Abstract

Disclosed is a computer-implemented method of composing, using natural language processing, a system for performing a task. The method comprises receiving a user input comprising a sequence of words; processing the user input using a neural network for entity recognition to identify, from the sequence of words, a term defining an event; and searching a data store having stored therein data indicative of a plurality of components, using the identified term, to determine a component for the system.

IPC Classes  ?

• G06F 30/12 - Geometric CAD characterised by design entry means specially adapted for CAD, e.g. graphical user interfaces [GUI] specially adapted for CAD
• G06F 40/40 - Processing or translation of natural language
• G06F 40/279 - Recognition of textual entities
• G06F 8/34 - Graphical or visual programming

Abstract

A method for extracting latent vector autoregressive (LaVAR) models with full interactions amongst mutually independent dynamic latent variables (DLV) from multi-dimensional time series data comprising: detecting, by a plurality of sensors, dynamic samples of data corresponding to a plurality of original variables; analyzing, using a controller, the dynamic samples of data to determine a plurality of latent variables that represent variation in the dynamic samples of data; estimating an estimated current value for all of the latent variables, wherein the estimation for all of the latent values is conducted simultaneously through an iterative process; and wherein each of the latent variables are contemporaneously uncorrelated.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation
• G06F 17/16 - Matrix or vector computation

Abstract

A method, system, apparatus and a non-transitory computer-readable medium storing instruction thereon is provided for predicting a probability of a synergistic effect between a combination of drugs in the treatment of, for example, a complex disease, such as cancer, through the application of an end-to-end deep learning framework based on a protein-protein interaction (PPI) network, drug-protein associations and cell line-protein associations.

IPC Classes  ?

• G16B 5/20 - Probabilistic models
• G16H 70/40 - ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage

Abstract

One embodiment provides a method for controlling a microagent in a workspace. The method includes providing a plurality of magnetic sources and generating a rotating gradient magnetic field by activating the plurality of magnetic sources differently such that a driving force is created to drive the microagent towards an aggregation center in the workspace.

IPC Classes  ?

• H01H 47/00 - Circuit arrangements not adapted to a particular application of the relay and designed to obtain desired operating characteristics or to provide energising current
• H01F 7/06 - ElectromagnetsActuators including electromagnets
• A61N 2/00 - Magnetotherapy

Abstract

2 battery capable of powering an intelligent and flexible electronics for health monitoring purposes with different biosensors.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
• B32B 5/02 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by structural features of a layer comprising fibres or filaments
• B32B 5/24 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer
• B32B 15/14 - Layered products essentially comprising metal next to a fibrous or filamentary layer
• D06M 11/13 - Ammonium halides or halides of elements of Groups 1 or 11 of the Periodic Table
• H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
• H01M 4/96 - Carbon-based electrodes
• H01M 8/0232 - Metals or alloys
• H01M 12/04 - Hybrid cellsManufacture thereof composed of a half-cell of the fuel-cell type and of a half-cell of the primary-cell type
• D06M 101/06 - Vegetal fibres cellulosic

Abstract

A polypeptide and an application thereof as a CCK receptor agonist/antagonist. The polypeptide has relatively high agonistic activity/antagonistic activity on a CCK receptor. Compared with a polypeptide CCK4, the polypeptide has a longer half-life period and curative effect duration in vivo. Experiments prove that the polypeptide has an obvious improvement effect on spatial memory deficits of old mice, old memory deficient mice, and Alzheimer's disease mice, such that the polypeptide has great application potential.

IPC Classes  ?

• C07K 5/117 - Tetrapeptides the first amino acid being heterocyclic, e.g. Pro, His, Trp
• A61K 38/07 - Tetrapeptides
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 25/16 - Anti-Parkinson drugs

Abstract

An underwater vehicle for performing a variety of linear motions and turning motions with better stability and agility is disclosed. The underwater vehicle includes a main body, a front-drive mechanism, a rear-drive mechanism, and a steering assembly. The main body has a front end and a rear end, which defines a longitudinal axis extending from the front end to the rear end of the main body. The front-drive mechanism is connected to the main body to provide a forward propelling force in a direction parallel to the longitudinal axis. The steering assembly is fixed to the rear end and coupled to the rear-drive mechanism. The steering assembly is configured to rotate the rear-drive mechanism with respect to the longitudinal axis by a body angle for providing a lateral force on the main body.

IPC Classes  ?

• B63G 8/08 - Propulsion
• B63G 8/16 - Control of attitude or depth by direct use of propellers or jets
• B63G 8/00 - Underwater vessels, e.g. submarines

Abstract

DeepOPF-V, a deep neural network (DNN)-based voltage-constrained approach for solving an alternating-current optimal power flow (AC-OPF) problem, is used to determine an operating point of an AC electrical power system. DeepOPE-V advantageously uses two DNNs to separately determine voltage magnitudes and voltage phase angles of buses in the system without cross-over operations between the two DNNs. A computation complexity is reduced when compared to using a single DNN for generating both the magnitudes and phase angles, allowing high computation efficiency achieved by DeepOPE-V. Remaining variables of the system are computed based on the determined magnitudes and phase angles. A solution for the operating condition is predicted. A fast post-processing (PP) method is developed to improve the feasibility of the predicted solution. The PP method uses linear adjustment to adjust the predicted solution to improve the solution feasibility while enabling fast execution of the PP method.

IPC Classes  ?

• H02J 13/00 - Circuit arrangements for providing remote indication of network conditions, e.g. an instantaneous record of the open or closed condition of each circuitbreaker in the networkCircuit arrangements for providing remote control of switching means in a power distribution network, e.g. switching in and out of current consumers by using a pulse code signal carried by the network
• G01R 19/00 - Arrangements for measuring currents or voltages or for indicating presence or sign thereof
• G01R 25/00 - Arrangements for measuring phase angle between a voltage and a current or between voltages or currents
• G06N 3/045 - Combinations of networks
• H02J 3/16 - Circuit arrangements for ac mains or ac distribution networks for adjusting voltage in ac networks by changing a characteristic of the network load by adjustment of reactive power

Abstract

Systems and methods for genome sequence compression and decompression are provided. The method for compression encoding of a genome sequence includes partitioning a genome sequence into a plurality of Group of Bases (GoBs) and processing each of the plurality of GoBs independently to encode the genome sequence into a bit stream. Processing each of the plurality of GoBs includes dividing each of the plurality of GOBs into a first part and a second part, the first part including an initial context part and the second part including a learning-based inference part. The processing each of the plurality of GoBs further includes encoding the first part in accordance with a Markov model, encoding the second part in accordance with a learning-based model, and encoding the encoded first part and the encoded second part into the bit stream with an arithmetic encoder. The learning-based model may include Long and Short-Term Memory (LSTM)-based neural networks.

IPC Classes  ?

• H03M 7/34 - Conversion to or from delta modulation, i.e. one-bit differential modulation adaptive
• G16B 50/50 - Compression of genetic data
• G16B 40/20 - Supervised data analysis
• H03M 7/30 - CompressionExpansionSuppression of unnecessary data, e.g. redundancy reduction
• G06F 16/22 - IndexingData structures thereforStorage structures
• G06N 7/01 - Probabilistic graphical models, e.g. probabilistic networks