Disclosed herein are double stranded therapeutic oligonucleotide endosomal escape peptide conjugates and uses in therapeutic methods. In certain embodiments, the double stranded therapeutic oligonucleotide endosomal escape peptide conjugate comprises a pH sensitive polynucleotide strand and a therapeutic polynucleotide strand. In certain embodiments, the therapeutic polynucleotide strand is conjugated to an endosomal escape peptide (EEP). In certain embodiments, the double stranded therapeutic oligonucleotide endosomal escape peptide conjugate is attached to a particle. In certain embodiments, the double stranded therapeutic oligonucleotide endosomal escape peptide conjugate or coated particle is used in an antisense or other oligonucleotide therapy.
A capillary action-driven microfluidic system for body fluid analysis may include a microneedle device comprising: a microfluidic substrate comprising: an inlet channel configured to drive capillary movement of a fluid across the inlet channel, an outlet channel configured to drive capillary movement of the fluid across the outlet channel; and a crossflow filtration chamber having a crossflow filtration channel in fluidic communication with the inlet channel and the outlet channel, the crossflow filtration chamber configured to drive capillary movement of the fluid across a filtration boundary formed between the crossflow filtration channel and an interior volume defined by a microstructure pattern of the crossflow filtration chamber.
An exemplary system and method are disclosed for a microfluidic platform for on-chip apoptosis quantification using an impedance-based instrumented quantification chamber that can provide a direct measure of subpopulation with apoptosis cells within a cell population as the cells flow through the instrumented quantification chamber in the analysis. The exemplary system and method can accurately and quickly detect apoptotic markers of a cell in a stream of cells without disturbing cellular conditions to provide near real-time measure of apoptotic cell subpopulation and with minimal wet-lab processing.
Disclosed is an electrochemical cell comprising: an anode electrode, wherein the anode electrode comprises a conductive host material having a layered or a porous structure and comprising an amount of at least one zinc-alloying metal, wherein the conductive host material is configured to accommodate zinc metal deposition during a plating cycle and wherein the deposited zinc metal is substantially free of dendrites; an aqueous electrolyte; and wherein the anode electrode exhibits at least 50% utilization.
The disclosure provides in vivo methods of identifying a lipid nanoparticle that is optimized based on cellular state, delivery profile, or both for delivery into a specific single cell. The lipid nanoparticles contain an identifying DNA barcode and a VHH antibody. An agent simultaneously detects the DNA barcode, the VHH antibody, and endogenous mRNA of the cell to identify one or more viable cells having the DNA barcode and the VHH antibody at a single cell level. The cellular state of viable cells comprising the lipid nanoparticles is determined by sequencing and measuring reduced expression of one or more of an inflammatory gene, a toxicity gene, and a cell state gene compared to a cell not administered the lipid nanoparticle. Based on a favorable expression profile resulting in the cellular state, the lipid nanoparticle is selected.
Microneedles for drug delivery that include a wax or other meltable material and methods of making and using such microneedles are disclosed. A microneedle patch includes a backing layer; and an array of microneedles extending from the backing layer, wherein the microneedles each include a distal tip portion that includes a drug, and the microneedles are configured to be inserted into mammalian tissue and, at least a portion of each of the microneedles is configured to melt in the mammalian tissue. In some other cases, melt materials are used during manufacturing of the microneedles but do not melt in the skin.
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
7.
METHOD FOR RECOVERING RARE EARTH ELEMENTS AND OTHER PRODUCTS FROM ASH
Disclosed herein are systems and methods relating to simultaneous waste processing and recovery of rare earth elements from a waste ash source. In some examples, the method includes contacting a REE-containing waste ash source with a chelating agent, thereby forming a leachate comprising one or more REE and a first residual material; contacting a precipitation agent with the leachate to form a second residual material and a solid precipitate comprising an amount of the one or more REE; separating the solid precipitate from the second residual material; and hydrothermally treating (e.g., using recycled heat or new heat) the first and/or second residual materials under conditions effective to yield a processed material comprising zeolites.
C01B 39/02 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof
C22B 3/24 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means by adsorption on solid substances, e.g. by extraction with solid resins
C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
8.
SYSTEMS AND METHODS FOR VEHICLE SIGNALING AND BARGAINING
An improved vehicle signaling and control system (150) is provided. In one aspect the system uses existing sensors (110) in a vehicle (100) to detect when another vehicle is too close (400). When the too close vehicle is a following vehicle, the system may cause existing rear lights (105), such as rear brake lights, to activate and signal to a driver of the vehicle that they are too close and should slow down (440). In addition, the system may detect, using the sensors, that a lane adjacent to the too close vehicle is empty (450), and may further activate lights such as turn signals to signal to the driver that they should change lanes (460).
B60Q 1/50 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for indicating other intentions or conditions, e.g. request for waiting or overtaking
B60Q 1/34 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for indicating change of drive direction
B60Q 1/44 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for indicating braking action
B60Q 1/46 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for giving flashing caution signals during drive, other than signalling change of direction, e.g. flashing the headlights
A system of tracking load switching operations and fault clearing operations of at least one circuit breaker in a power circuit includes at least one coil antenna sensing changes in a magnetic field around the coil antenna. The changes in the magnetic field induce corresponding changes to a current or voltage in the at least one coil antenna. A receiver is connected to the at least one coil antenna and receives the current or voltage. A computer is connected to the receiver and stores a data stream that corresponds to the changes in magnetic field around the at least one coil antenna. The computer uses the data stream to generate a plurality of characteristic magnetic field waveforms for the at least one circuit breaker. The computer assembles a low frequency magnetic signature for a respective circuit breaker from the characteristic magnetic field waveforms generated for the respective circuit breaker.
A method for modeling a human respiratory tract. The method includes receiving a number of images, wherein each of the number of images include at least a portion of a human respiratory tract, generating, based on the number of images, a 3D model of at least a portion of the human respiratory tract, wherein the 3D model includes an uncapped endpoint of the human respiratory tract, and automatically capping the endpoint within the 3D model by identifying, using a computer-implemented algorithm, the endpoint of the human respiratory tract within the 3D model, generating a 3D model of a shape, aligning the 3D model of the shape with the endpoint by positioning a center of the 3D model of the shape at a centroid corresponding to the endpoint, and merging the 3D model of the shape with the 3D model.
The present disclosure generally relates to systems and methods for inhibiting formation of ground vortices about a nacelle of an aircraft. The present disclosure can include a nacelle including a plurality of ports. The plurality of ports can extend through the nacelle from an exterior surface to an interior surface. The plurality of ports can be configured to direct a fluid from the exterior surface to an interior of the nacelle, inhibiting formation of ground vortices. Ports can be passive ports, such that a passive port can direct a fluid from the exterior surface to the interior based on a difference in pressure. The nacelle can further include one or more shields configured to block fluid flow through at least a portion of ports of the plurality of ports. The one or more shields can be configured to block a flow of a fluid due to a mechanical actuation.
Disclosed are polymers and polymer compositions comprising metalized polyphosphazene. Also disclosed are polymer electrolytes comprising the disclosed herein polymers and polymer compositions, and film separators comprising polymers and polymer compositions. Also disclosed are batteries comprising an anode, a cathode and polymer electrolytes. Disclosed are also methods of making polymers, polymer compositions, and batteries.
An exemplary embodiment of the present disclosure An implantable device. comprising and external wall and a plurality of apertures. The external wall can have an open tubular shape. The plurality of apertures can be located in the external wall. At least a first portion of the plurality of apertures can be configured as suture holes for attaching the implantable device to the user. The implantable device can be configured to be implanted in a passageway of a user.
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (USA)
Inventor
Yang, Zheng
Lee, Wenke
Perdisci, Roberto
Abstract
An exemplary system and method are disclosed that can mitigate online social engineering attacks at scale using a real-time detection system configured to identify social engineering advertisements and to block users' navigation to potential social engineering websites. To detect SE-ads and block the subsequent events, the exemplary system and method can monitor a user's browsing session and evaluate each navigation to determine if it may be related to an SE-ad using trained AI features related to how the navigation was initiated and employing the features in a classification evaluation. Upon detection, the exemplary system and method can output a notification to warn the user.
Disclosed herein are an exemplary apparatus, system, and methods (e.g., Tactical Passive RFID transponder gloves with Morphological Actuation) comprising a glove made predominately of a resistive fabric that varies resistance per degree of deformation; comprising near field communication RFID tag readers, and a controller coupled to the glove to evaluate the varied resistance. A method of classifying RFID tags is also disclosed.
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
16.
BROADBAND COUPLER-BASED BALUN CONTINUOUS ACTIVE LOAD MODULATION POWER AMPLIFIER
The present disclosure provides a system for a wideband coupler balun with a load modulated power amplifier wherein the system can comprise a first port, a second port, a differential port, a differential main power amplifier, and an auxiliary power amplifier. The first port can be electrically connected to a first coupled line coupler. The second port can be electrically connected to a second coupled line coupler. The differential port can be electrically connected to the first and second coupled line coupler. The differential main amplifier can be configured to be electrically connected to the differential port. The auxiliary power amplifier can be configured to be electrically connected to the first port.
An electrode device provides non-invasive non-contact measurements of biological signals such as from the heart, muscles, or brain (ECG, EMG, EEG) from a subject. The exemplary electrode device is a non-contact sensor that does not make an ohmic/galvanic connection to the skin but rather acquires the signal by forming a capacitor with the skin at the sensing site. The exemplary electrode device is configured with a feedback path that is defined based on, or as a function, of proximity. Thus, in response to motion, unwanted currents are cancelled, and the gain does not change.
The present disclosure provides polymers and oligomers having a constitutional repeating unit of Formula I. A composition including the disclosed polymer and oligomer is also provided. Devices including the disclosed polymer, oligomer, or composition are also provided. A photovoltaic device is provided including at least one perovskite material layer and at least one hole transport layer including the disclosed polymer, oligomer, or composition.
An exemplary system and method employing physiological sensor fusion and trained artificial intelligence models to predict/estimate a time-to-completion for a user undergoing a structured activity. The time-to-completion may be determined at a given segment of the activity as defined only by the physiological sensor measurement. The exemplary system and method may provide individualized fitness information for a customized military training regimen or athlete programs, to provide comprehensive and localized snapshots of physical performance based on the entire history of the event/activity.
An exemplary embodiment of the present disclosure provides a photocatalyst system. This system includes a photocatalyst comprising an organic material infused with clusters of an inorganic material diffused throughout a bulk of the organic material, wherein the organic material and the clusters of the inorganic material are configured such that the organic material photosensitizes the inorganic material. Another exemplary embodiment of the present disclosure provides a method of photocatalyzing a reaction. This method includes providing any of the photocatalysts disclosed herein; mixing the photocatalyst with a reactant to form a reaction mixture; and exposing the reaction mixture to a light source.
B01J 31/28 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of the platinum group metals, iron group metals or copper
B01J 31/34 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of chromium, molybdenum or tungsten
A system for identifying mental stress in a user is provided herein. A first sensor has at least one electrode configured to contact the user's skin to measure heart-based electrical signals of the user. A second sensor has at least one light emitter and at least one light sensor. A third sensor has at least one force sensor and can be configured to measure movement signals of the user's body reflecting cardio-mechanical activity of the user. The heart-based electrical signals, PPG signals, and movement signals in real time are received by a processor via at least one electrical input of the system. A set of mental stress signatures are continuously determined. The mental stress signatures are provided to an inference model to determine a probability of an acute mental stress state of the user. An output can indicate whether the user is presently in an acute mental stress state.
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
22.
METHODS TO IMPART COLOR AND DURABLE PROPERTIES TO SUBSTRATES
Metal substrates comprising a colored coating and/or a protective coating disposed on at least a surface of the substrate. The colored coating can include a metal oxide coating integrally bonded to the terminal and produced by heat tinting or a titanium nitride containing material. The protective coating is derived from a material comprising one or more of aluminum oxide, silicon oxide, a superhydrophobic material, wherein the protective coating has a Scratch Resistance of at least about F, as determined by ASTM D336. Methods of making and using the coated metal substrates are also disclosed.
A method of forming a molecular separation device is provided. The method comprises growing or depositing a silica MFI zeolite coating on a ceramic support. The method further comprises growing a ZIF-8 coating on the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite comprises applying a first reactant fluid including a metal salt and a second reactant fluid including an imidazole reactant to the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite further comprises reacting the first and second reactant fluid with the silica MFI zeolite coating to produce the ZIF-8 coating. In certain implementations, at least a portion of the ZIF-8 coating is interspersed with a portion of the silica MFI coating. A molecular separation device including the ZIF-8 coating and the silica MFI zeolite is also disclosed.
A cell deactivation device includes a cell deactivation container. The cell deactivation container includes a plurality of microfluidic channels, a lid covering the plurality of microfluidic channels, the lid having a thickness of less than about 150 microns, and a distribution manifold configured to distribute a fluid to the plurality of microfluidic channels. The cell deactivation device further includes an irradiation source configured to generate an electron beam and transmit the electron beam through the lid of the cell deactivation container and into a fluid passing through the plurality of microfluidic channels.
The present disclosure relates to improved biomanufacturing systems and methods with an ability to effectively control process variability to consistently generate high-quality cell-based therapies. In particular, disclosed herein is a using model-based control for determining process parameters in a bioreactor in real time. Additionally disclosed herein is a system for generating an AI digital twin model for a commercial-scale bioreactor.
An automated sampling platform includes a gantry-style 2D or 3D actuator equipped with a syringe pump end effector configured to extract samples from a rubber septum placed in-line within a tubing-based system and to deposit the extracted samples into sealed cryovials for storage. This device can be employed for use in cell culture bioreactors, such as the Terumo Quantum, which include a waste line.
Various implementations include a limbed robotic module. The module includes a frame, a first and second motor, a yoke, and a leg. The first motor is rigidly coupled to the frame and has a rotatable first shaft. The second motor is rigidly coupled to the frame and has a rotatable second shaft. The yoke is rigidly coupled to the first shaft such that rotation of the first shaft rotates the yoke relative to the frame. The yoke has a shoulder extending radially outwardly from the first shaft. The leg has a first end, a second end, and a hinge portion disposed between the first and second ends. The hinge portion is hingedly coupled to the shoulder of the yoke. The first end is coupled to the second shaft such that rotation of the second shaft rotates the second end relative to the yoke.
B62D 57/032 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted supporting base and legVehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted feet or skid
B25J 9/08 - Programme-controlled manipulators characterised by modular constructions
B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
28.
Pallet manipulation and product transport using multi-robot teams
A system (300) for moving a load (10) on a floor to a selected destination includes plurality of robots (320). Each robot (100) includes at least two wheels (112) and a motor (136). Each robot (100) fits underneath the load (10). A lifting device secured to each robot (100) has a retracted state and a lifting state so that the robot (100) and the lifting device (120) can fit into the open area (14) when the lifting device (120) is in the retracted state and so that the load (10) is lifted off of the floor (11) when the lifting device (120) is in the lifting state. A central server (310) determines a configuration of robots to lift the load (10), assigns robots and instructs the robots to go under the load (10), lift the load (10) and move the load (10) to the destination (30).
B66F 9/06 - Devices for lifting or lowering bulky or heavy goods for loading or unloading purposes movable, with their loads, on wheels or the like, e.g. fork-lift trucks
B66F 7/06 - Lifting frames, e.g. for lifting vehiclesPlatform lifts with platforms supported by levers for vertical movement
Provided are ionizable lipids containing a piperazine moiety, as well as lipid nanoparticles that can be formed using the ionizable lipids for use in delivering nucleic acids and other therapeutic agents to specific cell types.
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
30.
LEARNING COORDINATION POLICIES OVER HETEROGENEOUS GRAPHS FOR HUMAN-ROBOT TEAMS VIA RECURRENT NEURAL SCHEDULE PROPAGATION
An exemplary deep learning-based system and method are disclosed for human-robot coordination under temporal constraints that has a Heterogeneous Graph-based encoder and a Recurrent Schedule Propagator. The encoder extracts relevant information about the initial environment, while the Propagator generates the consequential models of each task-agent assignments based on the initial model. Inspired by the sensory encoding and recurrent processing of the brain, the approach allows for fast schedule generation, removing the need to interact with the environment between every task-agent pair selection.
Disclosed herein are methods and systems for detecting high throughput transcriptional activation and/or transcriptional repression of target genes within a cell. Disclosed is a method for high throughput simultaneous transcriptional activation and/or transcriptional repression of target genes within a cell, comprising: introducing a multi-sgRNA cassette comprising two to six target gene sgRNAs in the cell, wherein each target gene sgRNA comprises a bacteriophage aptamer, wherein each of the two to six target gene sgRNAs is flanked by a Pol III promoter or tRNAs; and co-expressing a catalytically inactive nuclease with a transcriptional activator or a transcriptional repressor and an RNA binding protein, wherein the multi-sgRNA cassette controls the simultaneous transcriptional activation and transcriptional repression of two to six target genes in the cell.
An exemplary embodiment of the present disclosure provides a current sensor comprising a current input, a current output, a first current path, and a second current path parallel to the first current path, a Rogowski coil current sensor, and a controller. The first current path can comprise a first switch. When the first switch is in a closed position, current can flow along the first current path between the current input and the current output. The second current path can comprise a second switch. When the second switch is in a closed position, current can flow along the second current path between the current input and the current output. At least one of the first current path and the second current path can pass through an aperture of the Rogowski coil. The controller can be configured to control the first and second switches.
G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
33.
Thermal Evaporation-Growth of Halide Perovskites Through Phosphonic Acid Addition
H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing
A medical device reduces the risk of operating room fires caused by light sources by shielding the illuminated light cable from directly interacting with surgical drapes or patient skin. The device includes a silicone housing that mates circumferentially over existing endoscopic light cables and a thermal insulator can be positioned over the light emitting tip of the cable.
A61B 1/12 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with cooling or rinsing arrangements
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
Disclosed herein are continuous reaction systems comprising a reaction vessel defining an interior volume and containing a plurality of inert scaffold particles. The reaction vessel can comprise an inlet line to provide one or more reactants to the interior volume such that the one or more reactants contact the plurality of inert scaffold particles. The reaction vessel can further comprise an outlet line to remove one or more products from the interior volume that result from a contact between the one or more reactants and the plurality of inert scaffold particles. The reaction vessel can also include a sieve material disposed on the outlet line within the interior volume configured to reject the plurality of inert scaffold particles and allow the one or more products to pass into the outlet line.
B01J 8/12 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with moving particles moved by gravity in a downward flow
B01D 21/00 - Separation of suspended solid particles from liquids by sedimentation
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes
B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds
B01J 19/18 - Stationary reactors having moving elements inside
36.
METHODS AND COMPOSITIONS FOR LIPID NANOPARTICLE (LNP) MEDIATED DELIVERY OF MRNA ENCODED SYNTHETIC ANTIGENS FOR UNIVERSAL TUMOR TARGETING BY CAR T CELLS
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
Disclosed herein are methods of sorting antigen specific T cells without activating; methods that employ said sorting methods to engineer chimeric antigen receptor (CAR) T cells; methods that employ said sorting methods in adoptive cell therapies and kits comprising the components for performing the disclosed methods.
An exemplary embodiment of the present disclosure provides a method for treating a subject with cancer. The method includes administering, to a subject with cancer, a chemotherapeutic drug under conditions effective to treat the subject for cancer, and administering, to the subject, a G(alpha)i2 (Gαi2) inhibitor. Another embodiment of the present disclosure provides a method of reducing cell migration in a subject that is receiving a chemotherapeutic drug to inhibit cancer cells. The method includes administering a Gαi2 inhibitor.
In a method of fabricating high performance CMS membranes, in which a dual-layer hollow fiber precursor fiber membrane that contains a nano-particle-filler containing core layer is extruded, a sheath layer is co-extruded with the core layer so that at least a portion of the core layer is surrounded by the sheath layer. The nano-particle filler is defect sealed. The dual-layer hollow fiber precursor fiber and the sheath layer are pyrolysed. A CMS membrane includes a core layer, a sheath layer surrounding at least a portion of the core layer and a plurality of nanoparticles disposed in the core layer.
An exemplary embodiment of the present disclosure provides a method for generating in vitro wood. The method can comprise culturing a plurality of wood forming plant cells; encapsulating the plurality of wood forming plant cells in one or more hydrogels; developing one or more bioinks; and generating structures comprising the one or more bioinks. The one or more bioinks can comprise one or more plant cell culture medium components. In an exemplary embodiment, the plurality of wood forming plant cells are cambial meristematic cells, and can include genetically modified plant cells. The one or more bioinks can be configured to be loaded into a bioprinting system, which can generate the structures via an extrusion based method. The generated structures can be incubated to induce wood formation, monitored, and tested for superior material properties.
An exemplary active recirculation system and method for aerosol collection are disclosed that employ recirculation via one or more active pumps (e.g., peristaltic pumps) to continuously circulate a collection buffer within an aerosol collection frontend to improve the collection efficiency. In using less fluid volume, the exemplary active recirculation system and method increase the concentration of the target particle. A high concentration of particles may be advantageous when detecting pathogens downstream of collection. The aerosol collection frontend connects to a collection reservoir. During a collection cycle, a pump draws the fluid from the collection reservoir and pumps the collected fluid back into the collection front end at a set flow rate.
. There is great interest in developing strategies to identify proteolytic substrates. Synthetic peptide libraries are among the most widely used to screen substrates-based activity, however, this technique is limited by the size of libraries and is time-consuming. Several combinatorial library-based display technologies such as phage, bacteria and yeast display, can identify better substrates for protease activity with higher-throughput sequencing and enrichment of specific substrates over multiple rounds of selection. Even though these profiling techniques provide greater coverage of protease cleavable substrates, such cells are less capable of accessing difficult to deliver sites, pose immunogenicity concerns, and have not been applied to discriminate on-from off-target activity in vivo. Disclosed herein are in vitro and in vivo methods for screening protease substrates.
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
45.
MAGNETIC RESONANCE-GUIDED ABDOMINAL INTERVENTION ROBOT
A magnetic resonance-guided abdominal intervention robot system was developed consisting of two stacked stages, each with two degrees of freedom, that facilitate needle insertion and control. The robot was actuated using 3D-printed pneumatic turbines with magnetic resonance-conditional bevel gear transmission systems. Pneumatic valves and control mechatronics were located inside the MRI control room and were connected to the robot with pneumatic transmission lines and optical fibers. The system was compact and capable of fitting within a standard magnetic resonance imaging bore even with large patients.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
The present disclosure provides for analysis systems and methods of analyzing a sample. The present disclosure provides for acquiring a sample that includes targeted cargo-containing object (e.g., cell), trapping the targeted cargo-containing object, releasing the cargo of the targeted cargo containing object, and analyzing the cargo free of the signal deteriorating media. The analysis system can include a sample introduction system, an object cargo extraction system and a detection system. The sample introduction system acquires the sample (e.g., directly or indirectly).
Systems and methods are provided for personalizing autonomous driving. The system can receive historical data on a driver of the vehicle's performance and population data indicating a population driving style. Speed data can be recorded as the driver of the vehicle drives the vehicle during a trial period. The historical data, population data, and speed data can be input into a machine learning model to determine a style for the driver. The system can receive one or more parameters from the machine learning model indicating the style. These parameters can be applied to the vehicle's automated driving system.
An exemplary embodiment of the present disclosure provides a power converter comprising a transformer, a first bridge, a second bridge, and a DC blocking circuit. The transformer can comprise a first winding and a second winding. The first bridge can be electrically coupled to the first winding. The second bridge can be electrically coupled to the second winding. The DC blocking circuit can be electrically coupled in series to the first winding and the first bridge and configured to apply a DC voltage to compensate for DC voltage in the primary winding.
The present disclosure relates generally to methods for producing stucco compositions useful in making gypsum products. One aspect of the disclosure is a method for producing a stucco composition using dielectric calcination. Another aspect of the disclosure is a production process for a gypsum product using a stucco composition prepared by dielectric calcination.
An exemplary embodiment of the present disclosure provides a method of delivering molecules to a region of interest in a microfluidic device. The microfluidic device can comprise a primary channel, one or more secondary channels in fluid communication with the primary channel, and a plurality of fluid chambers in fluid communication with a respective secondary channel in the one or more secondary channels. The method can comprise: providing the microfluidic device; injecting a first fluid comprising first molecules of interest in microfluidic device at a first pressure; and injecting a second fluid comprising second molecules of interest in the microfluidic device at a second pressure greater than the first pressure.
The disclosed technology includes systems and methods of managing temperature distributions of phase change material. The disclosed technology can include a system comprising a platform having a passageway therethrough. The platform can include a density that is less than a density of the phase change material when in a solid phase and greater than a density of the phase change material when in a liquid phase. The system can further include a whip rod disposed at least partially in the passageway of the platform.
An exemplary embodiment of the present disclosure provides a device, a substrate and a doped material. The doped material comprises a group III metal nitride, and one of a p-type dopant or an n-type dopant. The doped material is disposed upon the substrate at a temperature below 1000° C. and comprises an increased dopant concentration. Also disclosed herein are methods for producing doped group III metal nitride produces comprising flowing a plasma comprising nitrogen from a remote plasma chamber into a growth chamber; introducing a group III metal and at least one of a p-type dopant or an n-type dopant into the growth chamber; and disposing, over a substrate at a temperature below about 1000° C., a conductive group III metal nitride product comprising an increased electrical carrier concentration.
H10D 62/85 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group III-V materials, e.g. GaAs
H10D 62/854 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group III-V materials, e.g. GaAs further characterised by the dopants
53.
IMAGE-GUIDED ROBOTIC SYSTEM AND METHOD WITH STEP-WISE NEEDLE INSERTION
An exemplary robotic needle insertion system is disclosed that can provide respiration compensated needle insertion for an accurate and efficient ablation, biopsy, draining placement of a needle, among other surgical procedures. The system employs a robotic instrument comprising (i) a needle insertion mechanism configured to deliver the needle insertion in a step-wise manner that mimics the current clinical practice by inserting the needle (e.g., RFA needle) according to respiration and other motion and (ii) a probe manipulation mechanism to direct an ultrasound probe to provide intraoperative image guidance for the needle insertion. The robotic instrument includes a multi-degrees of freedom (DoF) motion control and actuator to provide for the accurate targeting of the needle at any workspace location
An exemplary embodiment of the present disclosure provides a membrane comprising a wall configured to interact with a fluid. The wall can comprise a polyimide polymer functionalized with one or more polyethylene glycol (PEG) side groups.
B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide acids or similar polyimide precursors
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
55.
Non-invasive Method and System for Assessing Joint Conditions
An exemplary system and method that non-invasively assess the effusion state of a joint via the use of a non-invasive measurement device. The measurement device actively interrogates the bone connected to the joint and nearby tissue with mechanical or acoustic energy by applying an impulse or vibratory mechanical or acoustic energy into the bone to assess the response of the bone at its connecting joint and its proximate tissue. The measurement device may additionally interrogate the bone connected to the joint and nearby tissue with electrical energy by applying an impulse or vibratory electrical energy into the joint (e.g., knee) or its nearby tissue to assess the electrical response of the joint and its proximate tissue. In some embodiments, the sensors employ both mechanical interrogation and electrical interrogation of the joint for the non-invasive assessment, e.g., for bioimpedance characteristics of the tissue and joint.
The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of transducing target cells using a device. The device may include at least one continuous channel. The method may include delivering target cells and viral vectors into a transduction region of the channel. After transducing for some incubation time, a flushing solution may be delivered. The method may include collecting transduced cells after the transducing incubation time and the delivering of the flushing solution.
An exemplary authentication system and method that employ a short-range communicating token to perform a first authentication of a login device or user upon the authentication process initiated and prior to passwords or other biometric data being provided for a second authentication operation. The short-range non-networked token in this multi-factor authentication framework can beneficially be verified without user input while separating the username and password in the authentication process to mitigate attacks.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
58.
Salinity Exchange for Low-Cost and High-Quality Potable Water
An exemplary embodiment of the present disclosure provides a method for purifying salt water. The method comprises the steps of removing at least a portion of salt in the salt water to form a potable water and introducing the at least a portion of the salt removed from the salt water to a water feed.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen
National Institute of Standards and Technology (USA)
Inventor
Raman, Chandra
Donley, Elizabeth
Kitching, John
Li, Chao
Martinez, Gabriela
Mcgehee, William
Abstract
An exemplary embodiment of the present disclosure provides a chip-scale atomic beam system comprising an atomic vapor source, a plurality of channels, and a propagation chamber. The atomic vapor source chamber can comprise an atomic vapor source configured to emit an atomic vapor. The plurality of channels can have first ends and second ends. The first ends can be in fluid communication with the atomic vapor source chamber. The plurality of channels can be configured to collimate the atomic vapor as it moves through the plurality of channels from the first ends to the second ends. The propagation chamber can be in fluid communication with the second ends of the plurality of channels. The propagation chamber can have an internal pressure less than an internal pressure of the atomic vapor source chamber to enable the collimated atomic vapor to propagate through the propagation chamber.
Disclosed is a method of forming a plurality of core/shell nanoparticles comprising spray coating a plurality of ZnO particles with a carbon precursor to form a plurality of clusters having a ZnO-based core and a carbon-containing shell.
An implantable hybrid advanced molecular manufacturing regulator device containing engineered cells delivering cancer therapeutics to a subject. The device comprises a conductive scaffold in communication with a control module; a biochemical sensor module in communication with the control module; an oxygenator configured to produce oxygen and disposed inside the conductive scaffold; and at least one engineered cells encapsulation disposed in association with the conductive scaffold; wherein the at least one engineered cells encapsulation encapsulates engineered cells; wherein the engineered cells are configured to produce at least one cancer therapeutic agent; wherein the device is implantable.
A platform of a hybrid advanced molecular manufacturing regulator device containing engineered cells delivering cancer therapeutics to a subject comprises an implantable device disposed inside an internal cavity of a subject; and an external device disposed outside the internal cavity of the subject and in wireless communication with the implantable device, wherein the implantable device comprises a molecular manufacturing regulator and a communication module; wherein the external device comprises at least one transmission coil in wireless communication with the communication module.
A system for an electromechanical transfer or disconnect switch wherein the system can comprise one or more contacts. a mechanical lever, and an actuator. The mechanical lever can comprise a first end, which can comprise a pivot and one or more holes disposed proximal to the pivot configured to provide a variable mechanical gain, and a second end coupled to at least a first contact in the one or more contacts. The actuator may be a piezoelectric or magnetostrictive actuator and can comprise a first end and a second end wherein the second end can be couplable to the one or more holes on mechanical lever, such that actuation of the actuator may cause a displacement of the at least a first contact relative to at least a second contact in the one or more contacts. The second contact may be movable or stationary.
An exemplary embodiment of the present disclosure provides a device for use in cardiovascular interventions, the device comprising a flexible bioresorbable semilunar valve comprising a flexible circumferential body having a ring structure and a plurality of points extending from the ring structure along a longitudinal axis of the valve, a plurality of leaflets extending between the plurality of points, and a flexible cage disposed concentrically around the ring structure, the flexible cage configured to secure the flexible bioresorbable semilunar valve within a cardiac lumen. The device can be 3D printed.
An exemplary embodiment of the present disclosure provides a system for generating behavior profiles using an enrichment object such as an enrichment object, the system comprising at least one enrichment object comprising at least one magnetic sensor, at least one processor, and a memory. The memory can be in communication with the at least one processor and the at least one magnetic sensor, and can have stored thereon instructions that, when executed by the at least one processor, is configured to cause the system to analyze sensor data received in real time from the at least one magnetic sensor, and generate a behavioral profile based, at least in part, on the analyzed sensor data.
Disclosed herein are bacterial protease-activated prodrug compositions and methods of their use for the treatment and prevention of bacterial infection. Also disclosed are methods of reducing or eliminating defiant bacterial populations. An exemplary prodrug composition includes a cationic antimicrobial peptide conjugated to an anionic peptide with a protease-cleavable linker substrate, wherein the antimicrobial peptide is inactive while it is in conjugation with the anionic peptide. Upon cleavage by the protease, the cationic AMP is released from the anionic peptide and can act upon bacteria. The protease is specific to the bacteria that are present in the sample or the subject, creating an auto-titrating mechanism wherein the AMP is released from the peptide only when there is bacteria present.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G06F 30/20 - Design optimisation, verification or simulation
A dielectric material with heat transfer properties includes a first fluid and a second fluid different from the first fluid and miscible with the first fluid. The first fluid and the second fluid are mixed with each other so as to form a mixture and are kept at a temperature and a pressure so that the mixture is maintained in a supercritical phase. The mixture has at least one parameter that is preferably different from a corresponding parameter in both a supercritical phase of the first fluid and a supercritical phase of the second fluid. In a method of insulating electrical contacts and removing heat therefrom, the mixture is disposed about the electrical contacts and is maintained at a temperature and at a pressure that causes the mixture to be in a supercritical phase so that the mixture has favorable dielectric and heat transfer properties.
H01B 3/16 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties mainly consisting of inorganic substances gases
H01B 3/00 - Insulators or insulating bodies characterised by the insulating materialsSelection of materials for their insulating or dielectric properties
H01B 17/36 - Insulators having evacuated or gas-filled spaces
68.
SOLID OXIDE CELL SYSTEM WITH THERMALLY TOLERANT CELLS WITH PASSIVE THERMAL MANAGEMENT STRUCTURES
An exemplary system and method are disclosed that employs a cell component level passive thermal management structure in the interconnect (IC) of solid oxide fuel cells or electrolyzer cells that geometrically alters the interconnect material at regions for the largest temperature gradients. The result is an increased passive flattening of temperature profiles that intrinsically increases thermomechanical reliability, given changing current supply and corresponding heat generation conditions, to make the cells more "thermally tolerant" to variable operation and facilitate reduced balance-of-plant operations.
H01M 8/0258 - CollectorsSeparators, e.g. bipolar separatorsInterconnectors characterised by the configuration of channels, e.g. by the flow field of the reactant or coolant
C25B 9/70 - Assemblies comprising two or more cells
C25B 15/021 - Process control or regulation of heating or cooling
69.
MULTI-WAVELENGTH PHOTOPLETHYSMOGRAM SYSTEM AND METHOD WITH MOTION ARTIFACT DETECTION
A multi-wavelength PPG system and method configured with optimized mechanical configuration for a chest-worn device for electrocardiogram and multi-wavelength photoplethysmogram acquisition. The multi-wavelength PPG system includes an electrocardiogram sensing assembly having two or more electrodes configured to mount the chest-worn device to the subject's chest. The multi-wavelength photoplethysmogram sensing assembly is located in between the electrocardiogram sensing electrodes to be maintained at the optimal sensing location by the mounting of the electrocardiogram sensing electrodes. The multi-wavelength photoplethysmogram includes one or more additional PPG emitters to provide additional information that can be employed to assess the quality of a signal acquisition with respect to movement artifacts, e.g., to reduce motion artifacts and/or provide accurate target data segments of higher signal quality having improved accuracy for SpO2 estimation.
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
Railcar inspection systems, methods, and apparatuses are disclosed, including a railcar inspection portal. The railcar inspection portal includes a physical structure positioned around a railroad track, and through which a railcar can travel. The railcar inspection portal can include wheel detection sensors along the railroad track for detecting the presence of a railcar passing over the sensors. The sensors can transmit signals, corresponding to railcars passing over the sensors, to computing devices for determining railcar speeds. The railcar inspection portal can include imaging devices configured to capture images and readings of railcars passing through the inspection portal. Based on a determined speed corresponding to a passing railcar, the computing devices can control the imaging devices to capture specific areas or components of the passing railcar, or individual cars thereon. The computing devices can process the captured images to detect defects corresponding to the passing railcar, or individual cars thereon.
Systems and methods for gathering data on passing vehicles is disclosed. The system can comprise a support structure spanning across a railroad track; an overhead inspection system attached to the support structure and comprising one or more cameras for gathering data on the top portion of the passing railcar; a first side inspection system and a second side inspection system attached to the support structure, and each comprising one or more cameras and one or more lights and configured to capture images of opposing sides of a railcar; an undercarriage inspection system comprising one or more undercarriage inspection assemblies, each of which can comprise one or more cameras and one or more lights; and one or more tie-mounted inspection assemblies comprising one or more cameras and one or more lights.
Assemblies, systems, and methods for inspecting vehicles are disclosed. An assembly can comprise a first angled camera, a second angled camera, an upright camera, lights, and a housing configured to attach to a railway between opposing rails. The first angled camera can be oriented at least partially in a vertical direction and at least partially in a first horizontal direction, and directed to a first target region from a first viewpoint. The second angled camera can be oriented at least partially in the vertical direction and at least partially in a second horizontal direction that is substantially opposite the first horizontal direction, and directed to a second target region from a second viewpoint. The upright camera can be oriented substantially in a vertical direction, and configured to capture images of a third target region from a third viewpoint.
An inspection assembly can comprise a first camera, a second camera, one or more lights, and a housing. The first camera can be angled at least partially in a vertical direction and at least partially in a horizontal direction to thereby be configured to capture images of a target region in a three-dimensional space from a first viewpoint. The second camera can be positioned apart from the first camera, angled at least partially in the vertical direction and at least partially in the horizontal direction, and directed to the target region from a second viewpoint that is different from the first viewpoint. The housing can comprise a base and a shroud and can be configured to attach to one or more rail ties and to at least partially envelop the first camera and the second camera.
H04N 23/52 - Elements optimising image sensor operation, e.g. for electromagnetic interference [EMI] protection or temperature control by heat transfer or cooling elements
H04N 23/56 - Cameras or camera modules comprising electronic image sensorsControl thereof provided with illuminating means
74.
APPARATUSES, SYSTEMS, AND METHODS FOR MONITORING MOVING VEHICLES
Railcar inspection systems, methods, and apparatuses are disclosed, including a railcar inspection portal. The railcar inspection portal includes a physical structure positioned around a railroad track, and through which a railcar can travel. The railcar inspection portal can include wheel detection sensors along the railroad track for detecting the presence of a railcar passing over the sensors. The sensors can transmit signals, corresponding to railcars passing over the sensors, to computing devices for determining railcar speeds. The railcar inspection portal can include imaging devices configured to capture images and readings of railcars passing through the inspection portal. Based on a determined speed corresponding to a passing railcar, the computing devices can control the imaging devices to capture specific areas or components of the passing railcar, or individual cars thereon. The computing devices can process the captured images to detect defects corresponding to the passing railcar, or individual cars thereon.
B61L 27/57 - Trackside diagnosis or maintenance, e.g. software upgrades for vehicles or trains, e.g. trackside supervision of train conditions
B61L 27/53 - Trackside diagnosis or maintenance, e.g. software upgrades for trackside elements or systems, e.g. trackside supervision of trackside control system conditions
G06T 7/80 - Analysis of captured images to determine intrinsic or extrinsic camera parameters, i.e. camera calibration
G06V 20/54 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects of traffic, e.g. cars on the road, trains or boats
75.
APPARATUSES, SYSTEMS, AND METHODS FOR MONITORING MOVING VEHICLES
Railcar inspection systems, methods, and apparatuses are disclosed, including a railcar inspection portal. The railcar inspection portal includes a physical structure positioned around a railroad track, and through which a railcar can travel. The railcar inspection portal can include wheel detection sensors along the railroad track for detecting the presence of a railcar passing over the sensors. The sensors can transmit signals, corresponding to railcars passing over the sensors, to computing devices for determining railcar speeds. The railcar inspection portal can include imaging devices configured to capture images and readings of railcars passing through the inspection portal. Based on a determined speed corresponding to a passing railcar, the computing devices can control the imaging devices to capture specific areas or components of the passing railcar, or individual cars thereon. The computing devices can process the captured images to detect defects corresponding to the passing railcar, or individual cars thereon.
Railcar inspection systems, methods, and apparatuses are disclosed, including a railcar inspection portal. The railcar inspection portal includes a physical structure positioned around a railroad track, and through which a railcar can travel. The railcar inspection portal can include wheel detection sensors along the railroad track for detecting the presence of a railcar passing over the sensors. The sensors can transmit signals, corresponding to railcars passing over the sensors, to computing devices for determining railcar speeds. The railcar inspection portal can include imaging devices configured to capture images and readings of railcars passing through the inspection portal. Based on a determined speed corresponding to a passing railcar, the computing devices can control the imaging devices to capture specific areas or components of the passing railcar, or individual cars thereon. The computing devices can process the captured images to detect defects corresponding to the passing railcar, or individual cars thereon.
Railcar inspection systems, methods, and apparatuses are disclosed, including a railcar inspection portal. The railcar inspection portal includes a physical structure positioned around a railroad track, and through which a railcar can travel. The railcar inspection portal can include wheel detection sensors along the railroad track for detecting the presence of a railcar passing over the sensors. The sensors can transmit signals, corresponding to railcars passing over the sensors, to computing devices for determining railcar speeds. The railcar inspection portal can include imaging devices configured to capture images and readings of railcars passing through the inspection portal. Based on a determined speed corresponding to a passing railcar, the computing devices can control the imaging devices to capture specific areas or components of the passing railcar, or individual cars thereon. The computing devices can process the captured images to detect defects corresponding to the passing railcar, or individual cars thereon.
G06T 7/55 - Depth or shape recovery from multiple images
G06V 20/54 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects of traffic, e.g. cars on the road, trains or boats
H04N 23/11 - Cameras or camera modules comprising electronic image sensorsControl thereof for generating image signals from different wavelengths for generating image signals from visible and infrared light wavelengths
78.
DETERMINISTIC SEISMOCARDIOGRAM ANALYSIS FOR MONITORING AND DIAGNOSIS OF VALVULAR HEART DISEASE
An exemplary embodiment of the present disclosure provides a system for monitoring a status of a heart disease. The system can comprise a wearable sensor and a controller. The wearable sensor can be configured generate or capture a signal indicative of vibrations from a heart of a user. The controller can be configured to extract S2 sound time splits of the heart based, at least in part, on the signal.
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
A61B 5/347 - Detecting the frequency distribution of signals
A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
79.
ADENOSINE DEAMINASE 1 COMPOSITIONS AND METHODS FOR USING SAME
The invention is directed to mutants of adenosine deaminase 1 (ADA1) that have increased or prolonged stability or catalytic activity relative to wildtype ADA1, as well as compositions comprising the mutants and methods of using the mutants to treat various conditions.
An exemplary embodiment of the present disclosure provides a system for generating a set of stimulation parameters, the system comprising at least one processor and a memory in communication with the at least one processor and having stored thereon instructions that, when executed by the at least one processor, is configured to cause the system to analyze, using a machine learning model, data from the deep brain stimulation device or an electromyography and generate, in response to analyzing, at least in part, the data, a set of stimulation parameters for deep brain stimulation.
Systems and methods for determining microbubble dynamics. The method may comprise introducing at least one microbubble into a vessel. The method may also comprise providing ultrasound waves through an outer surface of the vessel and to at least a portion of the at least one microbubble, wherein the ultrasound waves cause the at least one microbubble to oscillate and emit acoustic waves. The method may further comprise receiving, via at least one receiver, the acoustic waves and generating acoustic emission data based on the acoustic waves. The method may further comprise determining, based at least in part on the acoustic emission data, an acoustic emission frequency of the at least one microbubble. The method may also comprise determining, based at least in part on the acoustic emission frequency, at least one dynamic property of the at least one microbubble.
G01N 29/14 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object using acoustic emission techniques
G01N 29/44 - Processing the detected response signal
82.
ALGORITHMS FOR FLOW CYTOMETRY COMPENSATION WITHOUT REQUIRING COMPENSATION CONTROLS
An exemplary embodiment of the present disclosure provides a method of classifying a plurality of cells, comprising: providing a sample comprising a plurality of cells, the plurality of cells comprising a plurality of cell types; performing a flow cytometry process on the plurality of cells to generate an observation matrix; generating a compensation matrix based on the observation matrix; modifying the observation matrix with the compensation matrix to generate a compensated observation matrix; and classifying each of the plurality of cells into a cell type based on the compensated observation matrix.
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
Embodiments in accordance with the present invention encompass a variety of polymers derived from polycyclic olefin monomers, such as hydrocarbon functionalized norbornenes. The polymers so formed function as ionomers and are suitable as anion exchange membrane for fabricating a variety of electrochemical devices, among others. More specifically, the ionomeric polymers used herein are derived from a variety of quaternized amino functionalized norbornene monomers and are lightly crosslinked (less than ten mol %). The membranes made therefrom exhibit very high ionic conductivity of up to 198 mS/cm at 80° C. This invention also relates to using an anion conducting solid polymer electrolyte as the ion conducting medium between the two electrodes and the ion conducting medium within the electrodes acting as the ionic conduit between electroactive material and electrolyte. The electrochemical devices made in accordance of this invention are useful as fuel cells, gas separators, and the like.
Embodiments of the present disclosure can perform more accurate localization and tracking in various applications where wireless signals are employed while overcoming bandwidth limitations in the realm of precise wireless ranging. In one aspect, a method of performing wireless contactless sensing is provided. The method can include: filtering a received signal using a filter to select non-contiguous frequency bands, determining phase information for the selected non-contiguous frequency bands, determining a time domain response of the determined phase information for the selected non-contiguous frequency bands, and determining a location of a target based on the determined time domain response.
G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
EMORY UNIVERSITY (USA)
GEORGIA TECH RESEARCH CORPORATION (USA)
Inventor
Hecker, Louise
Oyelere, Adegboyega
Wu, Bocheng
Abstract
The present disclosure relates to compounds, compositions, and methods for inhibiting Nox4 signaling. Also described are methods of treating fibrotic disorders (e.g, pulmonary fibrosis, heart fibrosis, kidney fibrosis, liver fibrosis, skin fibrosis, mediastinal fibrosis, retroperitoneal cavity fibrosis, bone marrow fibrosis, scleroderma or systemic sclerosis), acute respiratory distress syndrome (ARDS), and cancer (e.g, a sarcoma, a carcinoma, a hematological cancer, a solid tumor, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, non-small cell lung carcinoma, thyroid cancer, testicular cancer, pancreatic cancer, liver cancer, endometrial cancer, melanoma, glioma, leukemia, lymphoma, chronic myeloproliferative disorder, myelodysplastic syndrome, myeloproliferative neoplasm, plasma cell neoplasm (myeloma)) using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (USA)
EMORY UNIVERSITY (USA)
GEORGIA TECH RESEARCH CORPORATION (USA)
Inventor
Walunj, Dipak
Hecker, Louise
Oyelere, Adegboyega
Wu, Bocheng
Abstract
e.ge.g.e.g., a sarcoma, a carcinoma, a hematological cancer, a solid tumor, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, non-small cell lung carcinoma, thyroid cancer, testicular cancer, pancreatic cancer, liver cancer, endometrial cancer, melanoma, glioma, leukemia, lymphoma, chronic myeloproliferative disorder, myelodysplastic syndrome, myeloproliferative neoplasm, plasma cell neoplasm (myeloma)) using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
C07D 413/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
A61K 31/4045 - Indole-alkylaminesAmides thereof, e.g. serotonin, melatonin
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 11/00 - Drugs for disorders of the respiratory system
C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
87.
Dispatchable Decentralized Scalable Solar Generation Systems
An exemplary embodiment of the present disclosure provides a current source converter, comprising a transformer, a first circuit, and a second circuit. The transformer can comprise a first winding, a second winding, and a third winding. The first circuit can be electrically coupled to the first and second windings. The first circuit can comprise a battery port and a photovoltaic (PV) port. The battery port can be configured to interface with one or more batteries. The PV port can be configured to interface with one or more PV modules. The second circuit can be electrically coupled to the third winding. The second circuit can comprise an alternating current (AC) port configured to interface with an AC load.
H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
H02J 3/32 - Arrangements for balancing the load in a network by storage of energy using batteries with converting means
H02M 7/797 - Conversion of AC power input into DC power outputConversion of DC power input into AC power output with possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only
88.
AI SYSTEM AND METHOD FOR PARTS AND MANUFACTURER MATCHING BASED ON MANUFACTURING CAPABILITY MODELS
An exemplary system and method are disclosed for a shape similarity search via a trained AI model configured on both part shape and material properties, among others, to allow for searching against a database of parts to identify a set of candidate like models or parts. In some embodiments, the trained AI model can learn the capabilities of a manufacturing facilities to which the trained AI model can be interrogated to identify a candidate manufacturer for a given part having both part shape and material properties. The operation can be performed via federated learning for improved privacy.
G05B 19/4093 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by part programming, e.g. entry of geometrical information as taken from a technical drawing, combining this with machining and material information to obtain control information, named part programme, for the NC machine
G05B 19/4097 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form characterised by using design data to control NC machines, e.g. CAD/CAM
Embodiments of the present disclosure include improvements to millimeter wave backscatter RFID technology for rotational sensing. Embodiments of the present disclosure leverage the polarization mismatch of linearly polarized antennas to capture rotational motion with high accuracy. One embodiment described herein includes utilization of a four-antenna system, each featuring a different modulation frequency. This configuration allows for independent extraction of rotational information by observing the changes in signal amplitudes as the angle of rotation varies. With a polarization offset of 15° between successive antennas, the backscatter channels trace distinct curves, enabling the resolution of angular ambiguities.
G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
90.
LYMPHOID-LYMPHATICS-INTEGRATED ORGAN-ON-CHIP DEVICE AND METHOD
Organ-on-chip system, including a bio-engineered lung region that is functionally connected to a bio-engineered lymphatic region via a functionalized connection region. The bio-engineered lung region includes cultured or transplanted lung cells/tissue, which can mimic in vivo lung function, and the bio-engineered lymphatic region includes lymphatic cells/tissue, which can mimic in vivo lymphatic function. The connection region allows for stimuli and cell secretions to be transported between the lung region and the lymphatic region to confer immune competency to the lung region, as the lymphatic region can generate an immune response based on stimuli received from the lung region, for example, in response to infections or therapeutic agents
Board of Regents, The University of Texas System (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G21C 1/32 - Integral reactors, i.e. reactors wherein parts functionally associated with the reactor but not essential to the reaction, e.g. heat exchangers, are disposed inside the enclosure with the core
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
System and method for collection and separation of human waste are described. The system can include a vessel (102) configured to receive human waste and a solids separator (106). The solids separator can include a vacuum tank as well as an inlet chamber formed within the vacuum tank at the top portion, a solids containment portion formed in the base of the vacuum tank and positioned centrally within the vacuum tank, a liquid containment portion formed in the base of the vacuum tank and contained within the vacuum tank surrounding the solids containment portion, and a separating filter having a cylindrical tubular shape and extending from the inlet chamber outlet to the solids containment portion. The separating filter forming a central separation volume within the vacuum tank. The inlet chamber is configured to receive the combined waste via an inlet (132) and to direct the combined waste to the central separation volume. The liquid portion of the combined waste allowed to flow through the separating filter to an outer portion surrounding the central separation volume and to collect in the liquid containment portion of the base. The solids portion of the combined waste contained within the central separation volume and collected in the solids containment portion of the base.
C02F 11/128 - Treatment of sludgeDevices therefor by de-watering, drying or thickening by mechanical de-watering using batch processes
C02F 103/00 - Nature of the water, waste water, sewage or sludge to be treated
E03D 5/014 - Special constructions of flushing devices combined with movable closure elements in the bowl outlet with devices for separate removal of liquids and solids
93.
HIGH TEMPERATURE-PHASE NIOBIUM PENTOXIDE (H-NB2O5) BASED ELECTRODES FOR HIGH-POWER LITHIUM-ION (US NP)
In a method of making an electrode, a binder is dissolved in a solvent to form a solution. An Nb2O5 hydrate-based electrode material powder is suspended in the solution to form a slurry. A predetermined thickness of the slurry is dispensed onto a conductive member so that the slurry has a mass loading in a range of 1 mg cm−2 to 2 mg cm−2. The conductive member and the slurry are dried to form the electrode. A battery includes an anode, a cathode, an electrolyte and a separator. The anode includes a graphite-modified Nb2O5 composite electrode material powder applied to a conductive member. The electrolyte is in electrical communication with the anode and the cathode. The separator is permeable to the electrolyte and is disposed between the anode from the cathode.
Toyota Motor Engineering & Manufacturing North America, Inc. (USA)
Georgia Tech Research Corporation (USA)
Inventor
Song, Yuyang
Tanaka, Masato
Yue, Liang
Qi, Hang
Abstract
A shape-morphing structure includes a cold draw programmable grayscale digital light processing 3D printed unitary hinge component comprising at least one glassy state portion and at least one rubbery state portion. The at least one glassy state portion has a glassy state recovery temperature and the at least one rubbery state portion has a rubbery state recovery temperature and different than the glassy state recovery temperature.
E05D 1/02 - Pinless hingesSubstitutes for hinges made of one piece
B33Y 80/00 - Products made by additive manufacturing
C08F 220/18 - Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
C09D 4/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
C09D 133/06 - Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
A sensing layer composition is provided. The sensing layer composition is particularly suited to be adhered to at least one side of one or more waveguide channels in/on a waveguide chip of an interferometric system. The sensing layer composition is adapted to bind or be selectively disturbed by one or more fluoro-containing substances via optical interferometric analysis.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/75 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G01C 3/30 - Measuring distances in line of sightOptical rangefinders using a parallactic triangle with fixed angles and a base of variable length at, near, or formed by, the object with provision for reduction of the distance into the horizontal plane with adaptation to the measurement of the height of an object, e.g. tacheometers
G21C 3/54 - Fused salt, oxide, or hydroxide compositions
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
G21C 9/00 - Emergency protection arrangements structurally associated with the reactor
G21C 9/02 - Means for effecting very rapid reduction of the reactivity factor under fault conditions, e.g. reactor fuse
97.
ULTRAFAST CATALYTIC CO2 CAPTURE CATALYZED BY A NOVEL ULTRASOUND-TREATED IONIC LIQUID
A transformational energy efficient technology using ionic liquid (IL) to couple with monoethanolamine (MEA) for catalytic CO2 capture is disclosed. [EMmim+][NTF2−] based catalysts are rationally synthesized and used for CO2 capture with MEA. A catalytic CO2 capture mechanism is disclosed according to experimental and computational studies on the [EMmim+][NTF2−] for the reversible CO2 sorption and desorption.
An exemplary machine learning-based system and method are disclosed for a clinical tool that can provide a comprehensive prediction of ovarian cancer propensity using metabolite and metabolomic profiles acquired from ultra-performance liquid chromatography, high-resolution mass spectrometry (UPLC-MS) analysis. Each serum sample may be independently processed through two different columns (HILIC and C18 reversed phase). Different ionization modes (negative and positive) may be used. The clinical tool can validated to provide successful prediction of ovarian cancer by over 90%. Ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) and the like can be used.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
99.
A METHOD CALIBRATING POWER MONITORS FOR MOLTEN SALT REACTORS AT LOW POWER
Board of Regents, The University of Texas System (USA)
Inventor
Kelly, Ryan
Biegalski, Steven
Brownfield, Ryan
Farrar, Kraig
Gates, Tyler
Haas, Derek
Scherr, Jonathan
Shoemate, Jack
Tsvetkov, Pavel
Abstract
A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
A sensing layer composition is provided. The sensing layer composition is particularly suited to be adhered to at least one side of one or more waveguide channels in/on a waveguide chip of an interferometric system. The sensing layer composition is adapted to bind or be selectively disturbed by one or more fluoro-containing substances via optical interferometric analysis.
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
patents
