Provided is a high areal capacity loading electrode that includes: a metal current collector; and an active material layer on the metal current collector, wherein the electrode has high areal capacity loading of greater than or equal to about 2.0 mAh/cm2, and the electrode is perforated with holes spaced from each other at an average distance ranging from about 70 μm to about 900 μm. An energy storage device including the high loading electrode is also provided.
H01G 11/24 - Electrodes characterised by structural features of the materials making up or comprised in the electrodes, e.g. form, surface area or porosityElectrodes characterised by the structural features of powders or particles used therefor
H01M 4/131 - Electrodes based on mixed oxides or hydroxides, or on mixtures of oxides or hydroxides, e.g. LiCoOx
H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
H01M 4/38 - Selection of substances as active materials, active masses, active liquids of elements or alloys
H01M 4/505 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of manganese of mixed oxides or hydroxides containing manganese for inserting or intercalating light metals, e.g. LiMn2O4 or LiMn2OxFy
H01M 4/525 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of nickel, cobalt or iron of mixed oxides or hydroxides containing iron, cobalt or nickel for inserting or intercalating light metals, e.g. LiNiO2, LiCoO2 or LiCoOxFy
H01M 10/0525 - Rocking-chair batteries, i.e. batteries with lithium insertion or intercalation in both electrodesLithium-ion batteries
2.
A DOPED TITANIUM NIOBIUM-OXIDE LITHIUM-ION BATTERY ANODE WITH IMPROVED RATE CAPABILITY
To make an electrode material (312). Nb2O5 powder (110) is milled (112) to generate Nb2O5 nanoparticles. An oxidant is added to the Nb2O5 nanoparticles to form oxidant coated Nb2O5 nanoparticles (114). The oxidant coated Nb2O5 nanoparticles is sealed with a carbon compound that releases a carbon compound vapor, which polymerizes on the Nb2O5 nanoparticles, which agglomerate to form polymerized Nb2O5 nanoparticles (116). The polymerized Nb2O5 nanoparticles are calcinated to form a hierarchical N-rich carbon conductive electrode layer (118). An electrode (302) that includes a Ti2Nb10O29@NC (312) layer is applied to a conductive substrate (310). A battery (300) includes an anode (314), a cathode (302) and an electrolyte (318) between the anode and the cathode (302). The cathode (302) includes a Ti2Nb10029@NC@NC layer (312).
H01M 4/485 - Selection of substances as active materials, active masses, active liquids of inorganic oxides or hydroxides of mixed oxides or hydroxides for inserting or intercalating light metals, e.g. LiTi2O4 or LiTi2OxFy
Described herein are solid-state electrochemical cells incorporating a solid-state electrolyte and aluminum as an anode active material. The use of aluminum as an anode active material can drive an increase in energy density and specific energy as compared to cells using conventional lithium-ion anode materials (e.g., graphite). Pairing an aluminum anode with a solid-state electrolyte can further provide for improved safety in secondary cells as compared to cells using lithium metal anodes for less complex manufacturing compared to cells using liquid electrolytes or wet processed anode materials.
H01M 10/0585 - Construction or manufacture of accumulators having only flat construction elements, i.e. flat positive electrodes, flat negative electrodes and flat separators
4.
MILLIMETER-SCALE WIRELESS IMPLANTABLE AUTONOMOUS OXYGENATOR PLATFORM AND APPLICATIONS THEREOF
An oxygenation system producing oxygen for therapeutic cells housed in an implanted or external system housing the therapeutic cells. The oxygenation system comprises a mm-scale oxygenator having at least one metal electrode; a miniaturized application-specific integrated circuit (ASIC) controlling an oxygen production by the oxygenator; a miniaturized communication unit; and a miniaturized power unit.
C25B 1/04 - Hydrogen or oxygen by electrolysis of water
C25B 11/077 - Electrodes formed of electrocatalysts on a substrate or carrier characterised by the electrocatalysts material consisting of a single catalytic element or catalytic compound the compound being a non-noble metal oxide
PERFORMING A THREE-DIMENSIONAL COMPUTER VISION TASK USING A NEURAL RADIANCE FIELD GRID REPRESENTATION OF A SCENE PRODUCED FROM TWO-DIMENSIONAL IMAGES OF AT LEAST A PORTION OF THE SCENE
A system for performing a three-dimensional computer vision task using a neural radiance field grid representation of a scene produced from two-dimensional images of at least a portion of the scene can include a processor and a memory. A neural radiance field grid network module can produce, from the two-dimensional images, three-dimensional patches of the neural radiance field grid representation of the scene. A three-dimensional shifted window visual transformer module can produce, from the three-dimensional patches, a feature map. A first decoder module can produce, from the feature map, the neural radiance field grid representation of the scene to train the system. A second decoder module can produce, from the feature map, the neural radiance field grid representation of the scene to perform the three-dimensional computer vision task for a cyber-physical system.
An MRI-compatible robot including one or more fiducial markers, a first planar stage having a first joint configured to receive a surgical tool and a first mechanism configured to move the surgical tool, and a second planar stage having a second joint configured to receive the surgical tool and a second mechanism configured to move the surgical tool, wherein the second planar stage is generally parallel with the first planar stage.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61M 5/42 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
Systems and methods to integrate electrical sensors comprising parallel electrodes into microfluidic devices that are manufactured using soft lithography are disclosed herein. With minimal fabrication complexity, more uniform electric fields than conventional coplanar electrodes are produced. The methods disclosed are also more suitable for the construction of complex electrical sensor networks in microfluidic devices due to greater layout flexibility and provide improved sensitivity over conventional coplanar electrodes.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
G01N 15/12 - Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
G01N 33/487 - Physical analysis of biological material of liquid biological material
G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
A microneedle patch for creating a tattoo image on skin, wherein the microneedle patch includes a backing layer, and an array of microneedles extending from the backing layer, wherein the microneedles each include a distal tip portion that has a tattoo substance, wherein the microneedles are configured to be inserted into a subject's skin and to release the tattoo substance in the skin, thereby creating a tattoo image in the skin that is visible to the human eye. Each microneedle in the array of microneedles may correspond to a dot, or a pixel, of the tattoo image or a portion thereof.
An exemplary embodiment of the present disclosure provides a battery system comprising one or more battery modules, one or more thermal conduits, and one or more thermoelectric coolers. Each of the one or more battery modules can comprise a plurality of battery cells. The one or more thermal conduits can be coupled to the one or more battery modules. The one or more thermoelectric coolers can be coupled to the one or more thermal conduits. The one or more thermal conduits can be configured to allow thermal energy to flow from the one or more battery modules to the one or more thermoelectric coolers. The thermoelectric coolers can be configured to dissipate thermal energy received from the one or more battery modules via the one or more thermal conduits.
H01M 10/6551 - Surfaces specially adapted for heat dissipation or radiation, e.g. fins or coatings
H01M 10/6563 - Gases with forced flow, e.g. by blowers
H01M 10/6572 - Peltier elements or thermoelectric devices
H01M 10/658 - Means for temperature control structurally associated with the cells by thermal insulation or shielding
H01M 50/213 - Racks, modules or packs for multiple batteries or multiple cells characterised by their shape adapted for cells having curved cross-section, e.g. round or elliptic
H01M 50/477 - Spacing elements inside cells other than separators, membranes or diaphragmsManufacturing processes thereof characterised by their shape
12.
Cyclically-Arranged Split Ring Resonator-Based Acoustic Metamaterial
An exemplary embodiment of the present disclosure provides an acoustic metamaterial comprising a plurality of unit cells. Each unit cell can comprise a planar layer, a first partial ring in the planar layer, and a second partial ring in the planar layer. The first partial ring can extend around a midpoint of the planar layer and can have a first opening. The second partial ring can extend around the midpoint of the planar layer and can have a second opening.
An exemplary method and pneumatic vest system (also referred to herein as a V/Q vest) are disclosed for improving oxygenation that can reproduce the effects of proning treatment. The exemplary pneumatic vest can be used synergistically with proning, as a replacement therapy for proning treatment, and/or to monitor or assess whether patients would respond well to a proning treatment. The exemplary pneumatic vest can be integrated with sensors and intubation equipment. The compression vest system can integrate a mechanical ventilator with a pneumatic compression vest to improve oxygenation, provide potential alternative or bridge to proning patients, and/or reduce mechanical ventilatory morbidity.
The present disclosure provides for sorbents, methods of using sorbents and contactors to capture CO2, structures including the sorbent, and systems and devices using sorbents to capture CO2. The methods, systems, contactors, and sorbents of the present disclosure can be advantageous since they are robust and reduce the cost of capturing CO2, in particular from ambient air. The present disclosure provides for sorbents having a support and a CO2-philic phase that includes phosphite containing molecules, which leads to a sorbent that is effective for capturing CO2.
The present disclosure provides for sorbents, methods of using sorbents and contactors to capture CO2, structures including the sorbent, and systems and devices using sorbents to capture CO2. The methods, systems, contactors, and sorbents of the present disclosure can be advantageous since they are robust and reduce the cost of capturing CO2, in particular from ambient air. The present disclosure provides for sorbents having a support and a CO2-philic phase that includes phosphite containing molecules, which leads to a sorbent that is effective for capturing CO2.
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
An exemplary power conditioning method and system are disclosed using a power converter in combination with a diode bridge rectifier and a series transformer in which the power converter is configured to inject VARs to a high-speed rotating machine to compensate for the machine reactance. By injecting VARs into the machine using the power converter through the series transformer, the power converter can be fractionally rated, in terms of power rating, to a lower power rating which would otherwise have to be higher due to the reactance requirements due to its high-frequency input. And additionally, because of the lower power rating, the transformer can be beneficially rated for the corresponding power level of the machine. The operation of the diode bridge rectifier and a transformer does not add to the complexity of the control of the system or that of the power converter.
An exemplary embodiment of the present disclosure provides a quantitative phase imaging method, comprising: imaging a sample to obtain one or more raw captures: inputting the one or more raw captures into a deep learning neural network (DLNN); generating, using the DLNN, a quantitative phase image of the sample based on the one or more raw captures; and outputting the quantitative phase image.
G06V 20/69 - Microscopic objects, e.g. biological cells or cellular parts
G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
G06V 10/774 - Generating sets of training patternsBootstrap methods, e.g. bagging or boosting
G06V 10/82 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
A microbial fuel cell includes a first conductive electrode that hosts a plurality of microbes that break down organic matter to perform oxidation and release electrons. The first conductive electrode is an anode. The microbial fuel cell also includes a second conductive electrode operatively coupled to the first conductive electrode. The second conductive electrode is a cathode that is vertically oriented in soil that includes the organic matter. Additionally, at least a portion of the cathode is contact with air.
An exemplary system and method provide flight management monitoring for small, non-commercial aircrafts, e.g., for training/monitoring and maintenance tracking, using a smart phone and its associated sensors (or a remote instrumentation device of the same). The exemplary system and method employ low-cost sensors available on the smart phone or a small sensor instrument and analysis system to identify, in non-real time, flight regimes recorded for a given flight that can be later utilized by the flight or maintenance crew in flight training for the pilot or maintenance operations by the pilot or flight mechanic.
Systems and methods for measuring hemodynamic parameters with wearable cardiovascular sensing. An apparatus can include one or more sensors configured to measure an electrocardiogram signal of a user and one or more seismocardiogram (SCG) signals of the user, a memory and a processing system including one or more processors operatively coupled to the memory and the one or more sensors, and configured to receive the electrocardiogram and one or more SCG signals, and generate an assessment of heart health by determining one or more hemodynamic parameters based on the signals. The invention further includes a method for non-invasively monitoring heart health of a user including receiving an electrocardiogram signal from a first sensor of a wearable device, receiving one or more SCG signals from a second sensor of the wearable device, and generating the assessment of the heart health of the user by determining the one or more hemodynamic parameters.
Disclosed herein are compositions and methods for identifying materials suitable for functional delivery of a bioactive agent to a target tissue. These compositions and methods have the advantage of simultaneously screening a library of materials for the ability to deliver a bioactive agent to a cell, tissue, or organ. The compositions and methods can also be used to confirm that the agent is delivered in a manner sufficient for function of the agent.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
An exemplary embodiment provides an array antenna, comprising a transmitter aperture and a receiver aperture. The transmitter aperture can comprise a first plurality of printed circuit boards, each comprising first arrays of radiating elements. Each of the radiating elements in the first arrays of radiating elements can comprise first arrays of pixels. Each of the pixels in the first arrays of pixels can be conductive or non-conductive. The receiver aperture can comprise a second plurality of printed circuit boards, each comprising second arrays of radiating elements. Each of the radiating elements in the second arrays of radiating elements can comprise second arrays of pixels. Each of the pixels in the second arrays of pixels can be conductive or non-conductive. The transmitter and receiver apertures can be configured to transmit and receive, respectively, a single beam (such as a wireless communication signal).
H01Q 1/24 - SupportsMounting means by structural association with other equipment or articles with receiving set
H01Q 3/34 - Arrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the relative phase or relative amplitude of energisation between two or more active radiating elementsArrangements for changing or varying the orientation or the shape of the directional pattern of the waves radiated from an antenna or antenna system varying the distribution of energy across a radiating aperture varying the phase by electrical means
H01Q 21/06 - Arrays of individually energised antenna units similarly polarised and spaced apart
22.
SYSTEMS AND METHODS FOR QUEUING PACKETS FOR WIRELESS NETWORK TRANSMISSION
A method for queuing packets for wireless network transmission including determining a selected device based on rankings of a first client device and a second client device, determining a transmission link for the selected device by probabilistically selecting the transmission link from a number of transmission links based on a transmission link score indicating a connection quality of the transmission link, queuing data from the selected device in a transmission queue for transmission via the determined transmission link, and updating the weight for each client device of the first client device and the second client device based on whether data from the client device was added to the transmission queue.
A ferroelectric gate stack may include a semiconductor layer, a conductor layer facing the semiconductor layer, a plurality of ferroelectric layers spaced apart from each other between the semiconductor layer and the conductor layer, a tunnel dielectric layer between a first ferroelectric layer and a second ferroelectric layer among the plurality of ferroelectric layers, and an interface layer between the semiconductor layer and the first ferroelectric layer.
H10B 51/30 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory transistors characterised by the memory core region
G11C 11/22 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using electric elements using ferroelectric elements
H10B 51/20 - Ferroelectric RAM [FeRAM] devices comprising ferroelectric memory transistors characterised by the three-dimensional arrangements, e.g. with cells on different height levels
The present disclosure provides a method of fabricating a nanomodular circuit, the method can comprise: providing a plurality of circuit components; placing the plurality of nanomodular circuit components on a substrate; determining a map of the plurality of nanomodular circuit components on the substrate; determining one or more of routes and connection points to the plurality of nanomodular circuit components for a plurality of electrical interconnects based on the map and a desired function for the circuit; and connecting the plurality of circuit components with the plurality of electrical interconnects at the determined routes and connection points.
Electrochemical systems providing reversible operation of high specific energy or gravimetric energy, and high energy density or volumetric energy battery chemistries, methods of operating such systems, processes providing high energy densities and high power densities, and architectures for the successful implementation of such systems, methods and processes. A number of interconnected electrochemical reactors can be assembled to create a battery. By presenting fluidic reactants via pumping, injection and/or other circulation technologies that enable high specific energy, high utilization of reactants, and efficient thermal control, the operation of the electrochemical reactor/battery can be optimized. In a flow battery system and method for handling molten alkali metal and hydroxide species, the volume of the reactants is maximized over inactive components and thus increase energy density. Molten and gaseous reactants/products are fed to/removed from a central power conversion module from/fed to reservoirs for discharge/charge.
Disclosed is a reactor thermal management system. A molten salt reactor vessel and a second component (e.g., a drain tank) fluidly coupled with the molten salt reactor vessel are configured to receive a flow of a molten salt therewith. The reactor thermal management system includes an internal shield or vessel encompassing the molten salt reactor vessel and the second component, the internal shield or vessel defining a first thermally insulative region therein. The internal shield or vessel is configured to maintain the first thermally insulated region above a melting temperature of the molten salt during operation of the molten salt reactor vessel.
A smartphone-based hemoglobin (Hgb) assessment application quantitatively analyzes pallor in patient-sourced photos using image analysis algorithms to enable a noninvasive, accurate quantitative smartphone app for detecting anemia. A user takes a photo of his/her fingernail beds using the app and receives an accurate displayed Hgb level. Since fingernails do not contain melanocytes, the primary source of color of these anatomical features is blood Hgb. At the same time, quality control software minimizes the impact of common fingernail irregularities (e.g. leukonychia and camera flash reflection) on Hgb level measurement. Metadata recorded upon capturing the image is leveraged for determining a users' Hgb level thereby eliminating the need for external equipment. A personalized calibration of image data with measured Hgb levels improves the accuracy of the application.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/103 - Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A method for queuing packets for wireless network transmission including determining a selected device based on rankings of a first client device (210) and a second client device (220), determining a transmission link for the selected device by probabilistically selecting the transmission link from a number of transmission links (204) based on a transmission link score (206) indicating a connection quality of the transmission link, queuing data from the selected device in a transmission queue (208) for transmission via the determined transmission link, and updating the weight for each client device of the first client device (210) and the second client device (220) based on whether data from the client device was added to the transmission queue (208).
H04L 47/6275 - Queue scheduling characterised by scheduling criteria for service slots or service orders based on priority
H04L 47/628 - Queue scheduling characterised by scheduling criteria for service slots or service orders based on packet size, e.g. shortest packet first
A broadband-capable current/voltage sensing-based VSWR resilient true power/impedance detector and method are disclosed that can be used for single-ended interfaces of individual phased array elements of a phased array antenna, e.g., large-scaled integrated phased-arrays. The true power and impedance detectors, as Built-in-Self-Test (BiST or BIST) circuitries, may each employ an in situ load invariant power and impedance sensor to provide true measurements of power and impedance that can be used to detect and/or monitor for VSWR variations and/or variations in the antenna driving impedance due to antenna element coupling and/or other effects. The measured power and impedance output(s) of each BIST circuitry can then be used to adjust or drive respective passive or active tuning circuitry, e.g., in the power amplifier or other front-end circuitries of the phased array antenna, for performance recovery (or optimization) of a respective array element.
An exemplary embodiment of the present disclosure provides a method of making a sorbent, comprising: dissolving a hygroscopic salt in a solvent to form a first solution; impregnating a plurality of supports with the first solution, each of the plurality of supports having a plurality of mesopores; and evaporating the solvent from the solution to form a dry sorbent, such that at least a portion of the hydroscopic salt is impregnated within the plurality of mesopores of each of the supports to form composite sorbents. Another exemplary embodiment of the present disclosure provides a composite sorbent, comprising a hygroscopic salt; a plurality of mesoporous supports; a binder; and a crosslinker, wherein the hygroscopic salt is impregnated within the plurality of mesoporous supports.
E03B 3/28 - Methods or installations for obtaining or collecting drinking water or tap water from humid air
F24F 3/14 - Air-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatmentApparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling by humidificationAir-conditioning systems in which conditioned primary air is supplied from one or more central stations to distributing units in the rooms or spaces where it may receive secondary treatmentApparatus specially designed for such systems characterised by the treatment of the air otherwise than by heating and cooling by dehumidification
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01D 53/28 - Selection of materials for use as drying agents
31.
HUMAN-MACHINE INTERFACES VIA A SCALABLE SOFT ELECTRODE ARRAY
An exemplary system and method are disclosed that employs (i) a forearm-based soft wearable hand-gesture recognition system that may detect a user's hand gestures as sensed from electromyographic signals acquired at a user's forearm and (ii) an AI-based classifier to continuously determine in real-time hand gestures as HMI inputs from the sensed EMG signal. The forearm-based soft wearable electronic system may be integrated into a soft, all-in-one wearable device having a scalable electrode array and integrated wireless system that may can measure electromyograms for real-time continuous recognition of hand gestures.
A structure for adhering to a surface so as to support a desired weight includes a substrate and a polymer layer. The polymer layer is mounted on the substrate. A plurality of flaps are drawn from the polymer layer. Each of the plurality of flaps have dimensions and a density so that when the plurality of flaps are placed against the surface and when a coherent shear force is applied thereto, the plurality of flaps will adhere to the surface with a strength sufficient to support the desired weight.
F16B 2/12 - Clamps, i.e. with gripping action effected by positive means other than the inherent resistance to deformation of the material of the fastening external, i.e. with contracting action using sliding jaws
Board of Regents, The University of Texas System (USA)
Inventor
Haas, Derek
Robison, Jordan
Biegalski, Steven
Head, Timothy
Towell, Rusty
Clarno, Kevin
Petrovic, Bojan
Tsvetkov, Pavel
Scherr, Jonathan
Kimber, Mark
Abstract
An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
G21C 1/32 - Integral reactors, i.e. reactors wherein parts functionally associated with the reactor but not essential to the reaction, e.g. heat exchangers, are disposed inside the enclosure with the core
G21C 3/54 - Fused salt, oxide, or hydroxide compositions
G21C 7/30 - Control of nuclear reaction by displacement of reactor fuel or fuel elements
A system is described comprising a first controller configured to control a radial arm. The system further comprises a second controller configured to control a probe apparatus motor. The radial arm is configured to move a probe apparatus in a horizontal direction across a horizontal cross-section of a plasma plume generated by a thruster, in response to receiving a first control signal from the first controller. The probe apparatus motor is configured to move a probe, coupled to the probe apparatus, in a vertical direction across a vertical cross-section of the plasm plume, in response to receiving a second control signal from the second controller. And the probe is configured to detect an ion beam current density corresponding to the thruster, based at least in part on a movement of the probe apparatus in the horizontal direction and a movement of the probe in the vertical direction.
Disclosed herein are double stranded therapeutic oligonucleotide endosomal escape peptide conjugates and uses in therapeutic methods. In certain embodiments, the double stranded therapeutic oligonucleotide endosomal escape peptide conjugate comprises a pH sensitive polynucleotide strand and a therapeutic polynucleotide strand. In certain embodiments, the therapeutic polynucleotide strand is conjugated to an endosomal escape peptide (EEP). In certain embodiments, the double stranded therapeutic oligonucleotide endosomal escape peptide conjugate is attached to a particle. In certain embodiments, the double stranded therapeutic oligonucleotide endosomal escape peptide conjugate or coated particle is used in an antisense or other oligonucleotide therapy.
A capillary action-driven microfluidic system for body fluid analysis may include a microneedle device comprising: a microfluidic substrate comprising: an inlet channel configured to drive capillary movement of a fluid across the inlet channel, an outlet channel configured to drive capillary movement of the fluid across the outlet channel; and a crossflow filtration chamber having a crossflow filtration channel in fluidic communication with the inlet channel and the outlet channel, the crossflow filtration chamber configured to drive capillary movement of the fluid across a filtration boundary formed between the crossflow filtration channel and an interior volume defined by a microstructure pattern of the crossflow filtration chamber.
An exemplary system and method are disclosed for a microfluidic platform for on-chip apoptosis quantification using an impedance-based instrumented quantification chamber that can provide a direct measure of subpopulation with apoptosis cells within a cell population as the cells flow through the instrumented quantification chamber in the analysis. The exemplary system and method can accurately and quickly detect apoptotic markers of a cell in a stream of cells without disturbing cellular conditions to provide near real-time measure of apoptotic cell subpopulation and with minimal wet-lab processing.
Disclosed is an electrochemical cell comprising: an anode electrode, wherein the anode electrode comprises a conductive host material having a layered or a porous structure and comprising an amount of at least one zinc-alloying metal, wherein the conductive host material is configured to accommodate zinc metal deposition during a plating cycle and wherein the deposited zinc metal is substantially free of dendrites; an aqueous electrolyte; and wherein the anode electrode exhibits at least 50% utilization.
The disclosure provides in vivo methods of identifying a lipid nanoparticle that is optimized based on cellular state, delivery profile, or both for delivery into a specific single cell. The lipid nanoparticles contain an identifying DNA barcode and a VHH antibody. An agent simultaneously detects the DNA barcode, the VHH antibody, and endogenous mRNA of the cell to identify one or more viable cells having the DNA barcode and the VHH antibody at a single cell level. The cellular state of viable cells comprising the lipid nanoparticles is determined by sequencing and measuring reduced expression of one or more of an inflammatory gene, a toxicity gene, and a cell state gene compared to a cell not administered the lipid nanoparticle. Based on a favorable expression profile resulting in the cellular state, the lipid nanoparticle is selected.
Microneedles for drug delivery that include a wax or other meltable material and methods of making and using such microneedles are disclosed. A microneedle patch includes a backing layer; and an array of microneedles extending from the backing layer, wherein the microneedles each include a distal tip portion that includes a drug, and the microneedles are configured to be inserted into mammalian tissue and, at least a portion of each of the microneedles is configured to melt in the mammalian tissue. In some other cases, melt materials are used during manufacturing of the microneedles but do not melt in the skin.
A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
41.
METHOD FOR RECOVERING RARE EARTH ELEMENTS AND OTHER PRODUCTS FROM ASH
Disclosed herein are systems and methods relating to simultaneous waste processing and recovery of rare earth elements from a waste ash source. In some examples, the method includes contacting a REE-containing waste ash source with a chelating agent, thereby forming a leachate comprising one or more REE and a first residual material; contacting a precipitation agent with the leachate to form a second residual material and a solid precipitate comprising an amount of the one or more REE; separating the solid precipitate from the second residual material; and hydrothermally treating (e.g., using recycled heat or new heat) the first and/or second residual materials under conditions effective to yield a processed material comprising zeolites.
C01B 39/02 - Crystalline aluminosilicate zeolitesIsomorphous compounds thereofDirect preparation thereofPreparation thereof starting from a reaction mixture containing a crystalline zeolite of another type, or from preformed reactantsAfter-treatment thereof
C22B 3/24 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means by adsorption on solid substances, e.g. by extraction with solid resins
C22B 3/44 - Treatment or purification of solutions, e.g. obtained by leaching by chemical processes
C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
42.
SYSTEMS AND METHODS FOR VEHICLE SIGNALING AND BARGAINING
An improved vehicle signaling and control system (150) is provided. In one aspect the system uses existing sensors (110) in a vehicle (100) to detect when another vehicle is too close (400). When the too close vehicle is a following vehicle, the system may cause existing rear lights (105), such as rear brake lights, to activate and signal to a driver of the vehicle that they are too close and should slow down (440). In addition, the system may detect, using the sensors, that a lane adjacent to the too close vehicle is empty (450), and may further activate lights such as turn signals to signal to the driver that they should change lanes (460).
B60Q 1/50 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for indicating other intentions or conditions, e.g. request for waiting or overtaking
B60Q 1/34 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for indicating change of drive direction
B60Q 1/44 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for indicating braking action
B60Q 1/46 - Arrangement of optical signalling or lighting devices, the mounting or supporting thereof or circuits therefor the devices being primarily intended to indicate the vehicle, or parts thereof, or to give signals, to other traffic for giving flashing caution signals during drive, other than signalling change of direction, e.g. flashing the headlights
A system of tracking load switching operations and fault clearing operations of at least one circuit breaker in a power circuit includes at least one coil antenna sensing changes in a magnetic field around the coil antenna. The changes in the magnetic field induce corresponding changes to a current or voltage in the at least one coil antenna. A receiver is connected to the at least one coil antenna and receives the current or voltage. A computer is connected to the receiver and stores a data stream that corresponds to the changes in magnetic field around the at least one coil antenna. The computer uses the data stream to generate a plurality of characteristic magnetic field waveforms for the at least one circuit breaker. The computer assembles a low frequency magnetic signature for a respective circuit breaker from the characteristic magnetic field waveforms generated for the respective circuit breaker.
A method for modeling a human respiratory tract. The method includes receiving a number of images, wherein each of the number of images include at least a portion of a human respiratory tract, generating, based on the number of images, a 3D model of at least a portion of the human respiratory tract, wherein the 3D model includes an uncapped endpoint of the human respiratory tract, and automatically capping the endpoint within the 3D model by identifying, using a computer-implemented algorithm, the endpoint of the human respiratory tract within the 3D model, generating a 3D model of a shape, aligning the 3D model of the shape with the endpoint by positioning a center of the 3D model of the shape at a centroid corresponding to the endpoint, and merging the 3D model of the shape with the 3D model.
The present disclosure generally relates to systems and methods for inhibiting formation of ground vortices about a nacelle of an aircraft. The present disclosure can include a nacelle including a plurality of ports. The plurality of ports can extend through the nacelle from an exterior surface to an interior surface. The plurality of ports can be configured to direct a fluid from the exterior surface to an interior of the nacelle, inhibiting formation of ground vortices. Ports can be passive ports, such that a passive port can direct a fluid from the exterior surface to the interior based on a difference in pressure. The nacelle can further include one or more shields configured to block fluid flow through at least a portion of ports of the plurality of ports. The one or more shields can be configured to block a flow of a fluid due to a mechanical actuation.
Disclosed are polymers and polymer compositions comprising metalized polyphosphazene. Also disclosed are polymer electrolytes comprising the disclosed herein polymers and polymer compositions, and film separators comprising polymers and polymer compositions. Also disclosed are batteries comprising an anode, a cathode and polymer electrolytes. Disclosed are also methods of making polymers, polymer compositions, and batteries.
An exemplary embodiment of the present disclosure An implantable device. comprising and external wall and a plurality of apertures. The external wall can have an open tubular shape. The plurality of apertures can be located in the external wall. At least a first portion of the plurality of apertures can be configured as suture holes for attaching the implantable device to the user. The implantable device can be configured to be implanted in a passageway of a user.
UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (USA)
Inventor
Yang, Zheng
Lee, Wenke
Perdisci, Roberto
Abstract
An exemplary system and method are disclosed that can mitigate online social engineering attacks at scale using a real-time detection system configured to identify social engineering advertisements and to block users' navigation to potential social engineering websites. To detect SE-ads and block the subsequent events, the exemplary system and method can monitor a user's browsing session and evaluate each navigation to determine if it may be related to an SE-ad using trained AI features related to how the navigation was initiated and employing the features in a classification evaluation. Upon detection, the exemplary system and method can output a notification to warn the user.
Disclosed herein are an exemplary apparatus, system, and methods (e.g., Tactical Passive RFID transponder gloves with Morphological Actuation) comprising a glove made predominately of a resistive fabric that varies resistance per degree of deformation; comprising near field communication RFID tag readers, and a controller coupled to the glove to evaluate the varied resistance. A method of classifying RFID tags is also disclosed.
G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
G06K 7/10 - Methods or arrangements for sensing record carriers by electromagnetic radiation, e.g. optical sensingMethods or arrangements for sensing record carriers by corpuscular radiation
G06Q 10/087 - Inventory or stock management, e.g. order filling, procurement or balancing against orders
50.
BROADBAND COUPLER-BASED BALUN CONTINUOUS ACTIVE LOAD MODULATION POWER AMPLIFIER
The present disclosure provides a system for a wideband coupler balun with a load modulated power amplifier wherein the system can comprise a first port, a second port, a differential port, a differential main power amplifier, and an auxiliary power amplifier. The first port can be electrically connected to a first coupled line coupler. The second port can be electrically connected to a second coupled line coupler. The differential port can be electrically connected to the first and second coupled line coupler. The differential main amplifier can be configured to be electrically connected to the differential port. The auxiliary power amplifier can be configured to be electrically connected to the first port.
An electrode device provides non-invasive non-contact measurements of biological signals such as from the heart, muscles, or brain (ECG, EMG, EEG) from a subject. The exemplary electrode device is a non-contact sensor that does not make an ohmic/galvanic connection to the skin but rather acquires the signal by forming a capacitor with the skin at the sensing site. The exemplary electrode device is configured with a feedback path that is defined based on, or as a function, of proximity. Thus, in response to motion, unwanted currents are cancelled, and the gain does not change.
The present disclosure provides polymers and oligomers having a constitutional repeating unit of Formula I. A composition including the disclosed polymer and oligomer is also provided. Devices including the disclosed polymer, oligomer, or composition are also provided. A photovoltaic device is provided including at least one perovskite material layer and at least one hole transport layer including the disclosed polymer, oligomer, or composition.
An exemplary system and method employing physiological sensor fusion and trained artificial intelligence models to predict/estimate a time-to-completion for a user undergoing a structured activity. The time-to-completion may be determined at a given segment of the activity as defined only by the physiological sensor measurement. The exemplary system and method may provide individualized fitness information for a customized military training regimen or athlete programs, to provide comprehensive and localized snapshots of physical performance based on the entire history of the event/activity.
An exemplary embodiment of the present disclosure provides a photocatalyst system. This system includes a photocatalyst comprising an organic material infused with clusters of an inorganic material diffused throughout a bulk of the organic material, wherein the organic material and the clusters of the inorganic material are configured such that the organic material photosensitizes the inorganic material. Another exemplary embodiment of the present disclosure provides a method of photocatalyzing a reaction. This method includes providing any of the photocatalysts disclosed herein; mixing the photocatalyst with a reactant to form a reaction mixture; and exposing the reaction mixture to a light source.
B01J 31/28 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of the platinum group metals, iron group metals or copper
B01J 31/34 - Catalysts comprising hydrides, coordination complexes or organic compounds containing in addition, inorganic metal compounds not provided for in groups of chromium, molybdenum or tungsten
A system for identifying mental stress in a user is provided herein. A first sensor has at least one electrode configured to contact the user's skin to measure heart-based electrical signals of the user. A second sensor has at least one light emitter and at least one light sensor. A third sensor has at least one force sensor and can be configured to measure movement signals of the user's body reflecting cardio-mechanical activity of the user. The heart-based electrical signals, PPG signals, and movement signals in real time are received by a processor via at least one electrical input of the system. A set of mental stress signatures are continuously determined. The mental stress signatures are provided to an inference model to determine a probability of an acute mental stress state of the user. An output can indicate whether the user is presently in an acute mental stress state.
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A61B 5/352 - Detecting R peaks, e.g. for synchronising diagnostic apparatusEstimating R-R interval
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
56.
METHODS TO IMPART COLOR AND DURABLE PROPERTIES TO SUBSTRATES
Metal substrates comprising a colored coating and/or a protective coating disposed on at least a surface of the substrate. The colored coating can include a metal oxide coating integrally bonded to the terminal and produced by heat tinting or a titanium nitride containing material. The protective coating is derived from a material comprising one or more of aluminum oxide, silicon oxide, a superhydrophobic material, wherein the protective coating has a Scratch Resistance of at least about F, as determined by ASTM D336. Methods of making and using the coated metal substrates are also disclosed.
A method of forming a molecular separation device is provided. The method comprises growing or depositing a silica MFI zeolite coating on a ceramic support. The method further comprises growing a ZIF-8 coating on the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite comprises applying a first reactant fluid including a metal salt and a second reactant fluid including an imidazole reactant to the silica MFI zeolite coating. Growing the ZIF-8 coating on the silica MFI zeolite further comprises reacting the first and second reactant fluid with the silica MFI zeolite coating to produce the ZIF-8 coating. In certain implementations, at least a portion of the ZIF-8 coating is interspersed with a portion of the silica MFI coating. A molecular separation device including the ZIF-8 coating and the silica MFI zeolite is also disclosed.
A cell deactivation device includes a cell deactivation container. The cell deactivation container includes a plurality of microfluidic channels, a lid covering the plurality of microfluidic channels, the lid having a thickness of less than about 150 microns, and a distribution manifold configured to distribute a fluid to the plurality of microfluidic channels. The cell deactivation device further includes an irradiation source configured to generate an electron beam and transmit the electron beam through the lid of the cell deactivation container and into a fluid passing through the plurality of microfluidic channels.
The present disclosure relates to improved biomanufacturing systems and methods with an ability to effectively control process variability to consistently generate high-quality cell-based therapies. In particular, disclosed herein is a using model-based control for determining process parameters in a bioreactor in real time. Additionally disclosed herein is a system for generating an AI digital twin model for a commercial-scale bioreactor.
An automated sampling platform includes a gantry-style 2D or 3D actuator equipped with a syringe pump end effector configured to extract samples from a rubber septum placed in-line within a tubing-based system and to deposit the extracted samples into sealed cryovials for storage. This device can be employed for use in cell culture bioreactors, such as the Terumo Quantum, which include a waste line.
Various implementations include a limbed robotic module. The module includes a frame, a first and second motor, a yoke, and a leg. The first motor is rigidly coupled to the frame and has a rotatable first shaft. The second motor is rigidly coupled to the frame and has a rotatable second shaft. The yoke is rigidly coupled to the first shaft such that rotation of the first shaft rotates the yoke relative to the frame. The yoke has a shoulder extending radially outwardly from the first shaft. The leg has a first end, a second end, and a hinge portion disposed between the first and second ends. The hinge portion is hingedly coupled to the shoulder of the yoke. The first end is coupled to the second shaft such that rotation of the second shaft rotates the second end relative to the yoke.
B62D 57/032 - Vehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted supporting base and legVehicles characterised by having other propulsion or other ground-engaging means than wheels or endless track, alone or in addition to wheels or endless track with ground-engaging propulsion means, e.g. walking members with alternately or sequentially lifted feet or skid
B25J 9/08 - Programme-controlled manipulators characterised by modular constructions
B25J 9/10 - Programme-controlled manipulators characterised by positioning means for manipulator elements
62.
Pallet manipulation and product transport using multi-robot teams
A system (300) for moving a load (10) on a floor to a selected destination includes plurality of robots (320). Each robot (100) includes at least two wheels (112) and a motor (136). Each robot (100) fits underneath the load (10). A lifting device secured to each robot (100) has a retracted state and a lifting state so that the robot (100) and the lifting device (120) can fit into the open area (14) when the lifting device (120) is in the retracted state and so that the load (10) is lifted off of the floor (11) when the lifting device (120) is in the lifting state. A central server (310) determines a configuration of robots to lift the load (10), assigns robots and instructs the robots to go under the load (10), lift the load (10) and move the load (10) to the destination (30).
B66F 9/06 - Devices for lifting or lowering bulky or heavy goods for loading or unloading purposes movable, with their loads, on wheels or the like, e.g. fork-lift trucks
B66F 7/06 - Lifting frames, e.g. for lifting vehiclesPlatform lifts with platforms supported by levers for vertical movement
Provided are ionizable lipids containing a piperazine moiety, as well as lipid nanoparticles that can be formed using the ionizable lipids for use in delivering nucleic acids and other therapeutic agents to specific cell types.
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
C07D 295/13 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
64.
LEARNING COORDINATION POLICIES OVER HETEROGENEOUS GRAPHS FOR HUMAN-ROBOT TEAMS VIA RECURRENT NEURAL SCHEDULE PROPAGATION
An exemplary deep learning-based system and method are disclosed for human-robot coordination under temporal constraints that has a Heterogeneous Graph-based encoder and a Recurrent Schedule Propagator. The encoder extracts relevant information about the initial environment, while the Propagator generates the consequential models of each task-agent assignments based on the initial model. Inspired by the sensory encoding and recurrent processing of the brain, the approach allows for fast schedule generation, removing the need to interact with the environment between every task-agent pair selection.
Disclosed herein are methods and systems for detecting high throughput transcriptional activation and/or transcriptional repression of target genes within a cell. Disclosed is a method for high throughput simultaneous transcriptional activation and/or transcriptional repression of target genes within a cell, comprising: introducing a multi-sgRNA cassette comprising two to six target gene sgRNAs in the cell, wherein each target gene sgRNA comprises a bacteriophage aptamer, wherein each of the two to six target gene sgRNAs is flanked by a Pol III promoter or tRNAs; and co-expressing a catalytically inactive nuclease with a transcriptional activator or a transcriptional repressor and an RNA binding protein, wherein the multi-sgRNA cassette controls the simultaneous transcriptional activation and transcriptional repression of two to six target genes in the cell.
Disclosed herein are continuous reaction systems comprising a reaction vessel defining an interior volume and containing a plurality of inert scaffold particles. The reaction vessel can comprise an inlet line to provide one or more reactants to the interior volume such that the one or more reactants contact the plurality of inert scaffold particles. The reaction vessel can further comprise an outlet line to remove one or more products from the interior volume that result from a contact between the one or more reactants and the plurality of inert scaffold particles. The reaction vessel can also include a sieve material disposed on the outlet line within the interior volume configured to reject the plurality of inert scaffold particles and allow the one or more products to pass into the outlet line.
B01J 8/12 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with moving particles moved by gravity in a downward flow
B01D 21/00 - Separation of suspended solid particles from liquids by sedimentation
B01J 8/00 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes
B01J 8/02 - Chemical or physical processes in general, conducted in the presence of fluids and solid particlesApparatus for such processes with stationary particles, e.g. in fixed beds
B01J 19/18 - Stationary reactors having moving elements inside
An exemplary embodiment of the present disclosure provides a current sensor comprising a current input, a current output, a first current path, and a second current path parallel to the first current path, a Rogowski coil current sensor, and a controller. The first current path can comprise a first switch. When the first switch is in a closed position, current can flow along the first current path between the current input and the current output. The second current path can comprise a second switch. When the second switch is in a closed position, current can flow along the second current path between the current input and the current output. At least one of the first current path and the second current path can pass through an aperture of the Rogowski coil. The controller can be configured to control the first and second switches.
G01R 15/18 - Adaptations providing voltage or current isolation, e.g. for high-voltage or high-current networks using inductive devices, e.g. transformers
68.
Thermal Evaporation-Growth of Halide Perovskites Through Phosphonic Acid Addition
H10K 71/13 - Deposition of organic active material using liquid deposition, e.g. spin coating using printing techniques, e.g. ink-jet printing or screen printing
A medical device reduces the risk of operating room fires caused by light sources by shielding the illuminated light cable from directly interacting with surgical drapes or patient skin. The device includes a silicone housing that mates circumferentially over existing endoscopic light cables and a thermal insulator can be positioned over the light emitting tip of the cable.
A61B 1/12 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with cooling or rinsing arrangements
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61B 1/07 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
70.
METHODS AND COMPOSITIONS FOR LIPID NANOPARTICLE (LNP) MEDIATED DELIVERY OF MRNA ENCODED SYNTHETIC ANTIGENS FOR UNIVERSAL TUMOR TARGETING BY CAR T CELLS
A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
Disclosed herein are methods of sorting antigen specific T cells without activating; methods that employ said sorting methods to engineer chimeric antigen receptor (CAR) T cells; methods that employ said sorting methods in adoptive cell therapies and kits comprising the components for performing the disclosed methods.
An exemplary embodiment of the present disclosure provides a method for treating a subject with cancer. The method includes administering, to a subject with cancer, a chemotherapeutic drug under conditions effective to treat the subject for cancer, and administering, to the subject, a G(alpha)i2 (Gαi2) inhibitor. Another embodiment of the present disclosure provides a method of reducing cell migration in a subject that is receiving a chemotherapeutic drug to inhibit cancer cells. The method includes administering a Gαi2 inhibitor.
In a method of fabricating high performance CMS membranes, in which a dual-layer hollow fiber precursor fiber membrane that contains a nano-particle-filler containing core layer is extruded, a sheath layer is co-extruded with the core layer so that at least a portion of the core layer is surrounded by the sheath layer. The nano-particle filler is defect sealed. The dual-layer hollow fiber precursor fiber and the sheath layer are pyrolysed. A CMS membrane includes a core layer, a sheath layer surrounding at least a portion of the core layer and a plurality of nanoparticles disposed in the core layer.
An exemplary embodiment of the present disclosure provides a method for generating in vitro wood. The method can comprise culturing a plurality of wood forming plant cells; encapsulating the plurality of wood forming plant cells in one or more hydrogels; developing one or more bioinks; and generating structures comprising the one or more bioinks. The one or more bioinks can comprise one or more plant cell culture medium components. In an exemplary embodiment, the plurality of wood forming plant cells are cambial meristematic cells, and can include genetically modified plant cells. The one or more bioinks can be configured to be loaded into a bioprinting system, which can generate the structures via an extrusion based method. The generated structures can be incubated to induce wood formation, monitored, and tested for superior material properties.
. There is great interest in developing strategies to identify proteolytic substrates. Synthetic peptide libraries are among the most widely used to screen substrates-based activity, however, this technique is limited by the size of libraries and is time-consuming. Several combinatorial library-based display technologies such as phage, bacteria and yeast display, can identify better substrates for protease activity with higher-throughput sequencing and enrichment of specific substrates over multiple rounds of selection. Even though these profiling techniques provide greater coverage of protease cleavable substrates, such cells are less capable of accessing difficult to deliver sites, pose immunogenicity concerns, and have not been applied to discriminate on-from off-target activity in vivo. Disclosed herein are in vitro and in vivo methods for screening protease substrates.
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
78.
RECIRCULATION SYSTEM FOR AEROSOL COLLECTORS USING LIQUID COLLECTION BUFFER
An exemplary active recirculation system and method for aerosol collection are disclosed that employ recirculation via one or more active pumps (e.g., peristaltic pumps) to continuously circulate a collection buffer within an aerosol collection frontend to improve the collection efficiency. In using less fluid volume, the exemplary active recirculation system and method increase the concentration of the target particle. A high concentration of particles may be advantageous when detecting pathogens downstream of collection. The aerosol collection frontend connects to a collection reservoir. During a collection cycle, a pump draws the fluid from the collection reservoir and pumps the collected fluid back into the collection front end at a set flow rate.
A magnetic resonance-guided abdominal intervention robot system was developed consisting of two stacked stages, each with two degrees of freedom, that facilitate needle insertion and control. The robot was actuated using 3D-printed pneumatic turbines with magnetic resonance-conditional bevel gear transmission systems. Pneumatic valves and control mechatronics were located inside the MRI control room and were connected to the robot with pneumatic transmission lines and optical fibers. The system was compact and capable of fitting within a standard magnetic resonance imaging bore even with large patients.
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
The present disclosure provides for analysis systems and methods of analyzing a sample. The present disclosure provides for acquiring a sample that includes targeted cargo-containing object (e.g., cell), trapping the targeted cargo-containing object, releasing the cargo of the targeted cargo containing object, and analyzing the cargo free of the signal deteriorating media. The analysis system can include a sample introduction system, an object cargo extraction system and a detection system. The sample introduction system acquires the sample (e.g., directly or indirectly).
Systems and methods are provided for personalizing autonomous driving. The system can receive historical data on a driver of the vehicle's performance and population data indicating a population driving style. Speed data can be recorded as the driver of the vehicle drives the vehicle during a trial period. The historical data, population data, and speed data can be input into a machine learning model to determine a style for the driver. The system can receive one or more parameters from the machine learning model indicating the style. These parameters can be applied to the vehicle's automated driving system.
An exemplary embodiment of the present disclosure provides a power converter comprising a transformer, a first bridge, a second bridge, and a DC blocking circuit. The transformer can comprise a first winding and a second winding. The first bridge can be electrically coupled to the first winding. The second bridge can be electrically coupled to the second winding. The DC blocking circuit can be electrically coupled in series to the first winding and the first bridge and configured to apply a DC voltage to compensate for DC voltage in the primary winding.
The present disclosure relates generally to methods for producing stucco compositions useful in making gypsum products. One aspect of the disclosure is a method for producing a stucco composition using dielectric calcination. Another aspect of the disclosure is a production process for a gypsum product using a stucco composition prepared by dielectric calcination.
An exemplary embodiment of the present disclosure provides a method of delivering molecules to a region of interest in a microfluidic device. The microfluidic device can comprise a primary channel, one or more secondary channels in fluid communication with the primary channel, and a plurality of fluid chambers in fluid communication with a respective secondary channel in the one or more secondary channels. The method can comprise: providing the microfluidic device; injecting a first fluid comprising first molecules of interest in microfluidic device at a first pressure; and injecting a second fluid comprising second molecules of interest in the microfluidic device at a second pressure greater than the first pressure.
The disclosed technology includes systems and methods of managing temperature distributions of phase change material. The disclosed technology can include a system comprising a platform having a passageway therethrough. The platform can include a density that is less than a density of the phase change material when in a solid phase and greater than a density of the phase change material when in a liquid phase. The system can further include a whip rod disposed at least partially in the passageway of the platform.
An exemplary embodiment of the present disclosure provides a device, a substrate and a doped material. The doped material comprises a group III metal nitride, and one of a p-type dopant or an n-type dopant. The doped material is disposed upon the substrate at a temperature below 1000° C. and comprises an increased dopant concentration. Also disclosed herein are methods for producing doped group III metal nitride produces comprising flowing a plasma comprising nitrogen from a remote plasma chamber into a growth chamber; introducing a group III metal and at least one of a p-type dopant or an n-type dopant into the growth chamber; and disposing, over a substrate at a temperature below about 1000° C., a conductive group III metal nitride product comprising an increased electrical carrier concentration.
H10D 62/85 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group III-V materials, e.g. GaAs
H10D 62/854 - Semiconductor bodies, or regions thereof, of devices having potential barriers characterised by the materials being Group III-V materials, e.g. GaAs further characterised by the dopants
87.
IMAGE-GUIDED ROBOTIC SYSTEM AND METHOD WITH STEP-WISE NEEDLE INSERTION
An exemplary robotic needle insertion system is disclosed that can provide respiration compensated needle insertion for an accurate and efficient ablation, biopsy, draining placement of a needle, among other surgical procedures. The system employs a robotic instrument comprising (i) a needle insertion mechanism configured to deliver the needle insertion in a step-wise manner that mimics the current clinical practice by inserting the needle (e.g., RFA needle) according to respiration and other motion and (ii) a probe manipulation mechanism to direct an ultrasound probe to provide intraoperative image guidance for the needle insertion. The robotic instrument includes a multi-degrees of freedom (DoF) motion control and actuator to provide for the accurate targeting of the needle at any workspace location
An exemplary embodiment of the present disclosure provides a membrane comprising a wall configured to interact with a fluid. The wall can comprise a polyimide polymer functionalized with one or more polyethylene glycol (PEG) side groups.
B01D 71/64 - PolyimidesPolyamide-imidesPolyester-imidesPolyamide acids or similar polyimide precursors
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
C08G 73/10 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
89.
Non-invasive Method and System for Assessing Joint Conditions
An exemplary system and method that non-invasively assess the effusion state of a joint via the use of a non-invasive measurement device. The measurement device actively interrogates the bone connected to the joint and nearby tissue with mechanical or acoustic energy by applying an impulse or vibratory mechanical or acoustic energy into the bone to assess the response of the bone at its connecting joint and its proximate tissue. The measurement device may additionally interrogate the bone connected to the joint and nearby tissue with electrical energy by applying an impulse or vibratory electrical energy into the joint (e.g., knee) or its nearby tissue to assess the electrical response of the joint and its proximate tissue. In some embodiments, the sensors employ both mechanical interrogation and electrical interrogation of the joint for the non-invasive assessment, e.g., for bioimpedance characteristics of the tissue and joint.
The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of transducing target cells using a device. The device may include at least one continuous channel. The method may include delivering target cells and viral vectors into a transduction region of the channel. After transducing for some incubation time, a flushing solution may be delivered. The method may include collecting transduced cells after the transducing incubation time and the delivering of the flushing solution.
An exemplary authentication system and method that employ a short-range communicating token to perform a first authentication of a login device or user upon the authentication process initiated and prior to passwords or other biometric data being provided for a second authentication operation. The short-range non-networked token in this multi-factor authentication framework can beneficially be verified without user input while separating the username and password in the authentication process to mitigate attacks.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
92.
Salinity Exchange for Low-Cost and High-Quality Potable Water
An exemplary embodiment of the present disclosure provides a method for purifying salt water. The method comprises the steps of removing at least a portion of salt in the salt water to form a potable water and introducing the at least a portion of the salt removed from the salt water to a water feed.
C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
H01M 8/22 - Fuel cells in which the fuel is based on materials comprising carbon or oxygen or hydrogen and other elementsFuel cells in which the fuel is based on materials comprising only elements other than carbon, oxygen or hydrogen
National Institute of Standards and Technology (USA)
Inventor
Raman, Chandra
Donley, Elizabeth
Kitching, John
Li, Chao
Martinez, Gabriela
Mcgehee, William
Abstract
An exemplary embodiment of the present disclosure provides a chip-scale atomic beam system comprising an atomic vapor source, a plurality of channels, and a propagation chamber. The atomic vapor source chamber can comprise an atomic vapor source configured to emit an atomic vapor. The plurality of channels can have first ends and second ends. The first ends can be in fluid communication with the atomic vapor source chamber. The plurality of channels can be configured to collimate the atomic vapor as it moves through the plurality of channels from the first ends to the second ends. The propagation chamber can be in fluid communication with the second ends of the plurality of channels. The propagation chamber can have an internal pressure less than an internal pressure of the atomic vapor source chamber to enable the collimated atomic vapor to propagate through the propagation chamber.
Disclosed is a method of forming a plurality of core/shell nanoparticles comprising spray coating a plurality of ZnO particles with a carbon precursor to form a plurality of clusters having a ZnO-based core and a carbon-containing shell.
An implantable hybrid advanced molecular manufacturing regulator device containing engineered cells delivering cancer therapeutics to a subject. The device comprises a conductive scaffold in communication with a control module; a biochemical sensor module in communication with the control module; an oxygenator configured to produce oxygen and disposed inside the conductive scaffold; and at least one engineered cells encapsulation disposed in association with the conductive scaffold; wherein the at least one engineered cells encapsulation encapsulates engineered cells; wherein the engineered cells are configured to produce at least one cancer therapeutic agent; wherein the device is implantable.
A platform of a hybrid advanced molecular manufacturing regulator device containing engineered cells delivering cancer therapeutics to a subject comprises an implantable device disposed inside an internal cavity of a subject; and an external device disposed outside the internal cavity of the subject and in wireless communication with the implantable device, wherein the implantable device comprises a molecular manufacturing regulator and a communication module; wherein the external device comprises at least one transmission coil in wireless communication with the communication module.
A system for an electromechanical transfer or disconnect switch wherein the system can comprise one or more contacts. a mechanical lever, and an actuator. The mechanical lever can comprise a first end, which can comprise a pivot and one or more holes disposed proximal to the pivot configured to provide a variable mechanical gain, and a second end coupled to at least a first contact in the one or more contacts. The actuator may be a piezoelectric or magnetostrictive actuator and can comprise a first end and a second end wherein the second end can be couplable to the one or more holes on mechanical lever, such that actuation of the actuator may cause a displacement of the at least a first contact relative to at least a second contact in the one or more contacts. The second contact may be movable or stationary.
An exemplary embodiment of the present disclosure provides a device for use in cardiovascular interventions, the device comprising a flexible bioresorbable semilunar valve comprising a flexible circumferential body having a ring structure and a plurality of points extending from the ring structure along a longitudinal axis of the valve, a plurality of leaflets extending between the plurality of points, and a flexible cage disposed concentrically around the ring structure, the flexible cage configured to secure the flexible bioresorbable semilunar valve within a cardiac lumen. The device can be 3D printed.
An exemplary embodiment of the present disclosure provides a system for generating behavior profiles using an enrichment object such as an enrichment object, the system comprising at least one enrichment object comprising at least one magnetic sensor, at least one processor, and a memory. The memory can be in communication with the at least one processor and the at least one magnetic sensor, and can have stored thereon instructions that, when executed by the at least one processor, is configured to cause the system to analyze sensor data received in real time from the at least one magnetic sensor, and generate a behavioral profile based, at least in part, on the analyzed sensor data.
Disclosed herein are bacterial protease-activated prodrug compositions and methods of their use for the treatment and prevention of bacterial infection. Also disclosed are methods of reducing or eliminating defiant bacterial populations. An exemplary prodrug composition includes a cationic antimicrobial peptide conjugated to an anionic peptide with a protease-cleavable linker substrate, wherein the antimicrobial peptide is inactive while it is in conjugation with the anionic peptide. Upon cleavage by the protease, the cationic AMP is released from the anionic peptide and can act upon bacteria. The protease is specific to the bacteria that are present in the sample or the subject, creating an auto-titrating mechanism wherein the AMP is released from the peptide only when there is bacteria present.
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
G06F 30/20 - Design optimisation, verification or simulation
