A first problem of the present invention is to provide a novel technique capable of producing iPS cells using epithelial cells such as keratinocytes. The present invention for solving the problem is a method for producing induced pluripotent stem cells using epithelial cells, the method including: a reprogramming step including introducing a reprogramming gene for reprogramming a nucleus, or a translation product thereof, into the epithelial cells; and an adherent culture step of adhering and culturing cells that have undergone the reprogramming step on a culture surface coated with a laminin or a fragment thereof.
An object of the present invention is to provide a novel technique for easy culture of mesenchymal stem cells from a removed hair. The present invention to solve the above problem is a method of culturing mesenchymal stem cells, and the method includes a culture step of culturing a hair acquired by removal and including a hair bulb covered with a dermal sheath tissue in a culture solution.
The present invention addresses the problem of providing a new technology for producing, from stem cells, a layered three-dimensional skin tissue in which an epidermal layer and a dermal layer are laminated. The present invention, which solves the above problem, is a method for producing a three-dimensional skin tissue, the method comprising a skin tissue formation process for producing a three-dimensional skin tissue in which a dermal layer and an epidermal layer are laminated. The skin tissue formation process includes a three-dimensional culturing process for placing, on a membrane which is provided to a culturing vessel and through which a culture solution can permeate, a three-dimensionally cultured product obtained through suspension culturing of stem cells, without dissecting the same, and culturing the same to obtain a layered three-dimensional skin tissue in which at least a dermal layer and an epidermal layer are laminated.
The present invention addresses the problem of providing novel technology for easily culturing mesenchymal stem cells from removed hair. To solve this problem, the present invention is a method for culturing mesenchymal stem cells comprising a culturing step in which a hair that has been acquired by being pulled out and that contains a hair bulb covered by dermal hair root sheath tissue is cultured in culture broth.
The first problem addressed by the present invention is to provide a novel technology with which it is possible to produce iPS cells using epithelial cells such as keratinocytes. To solve the above problem, the present invention is a method for producing induced pluripotent stem cells using epithelial cells that comprises a reprogramming step that includes introducing into epithelial cells a reprogrammed gene or a translation product thereof that reprograms nuclei and an adherent culture step that cultures the cells that have undergone the reprogramming step on a culture surface coated with laminin or a fragment thereof.
This solution providing system comprises: a storing unit for storing information on multiple solutions for improving a user condition which is one or both of the emotion and fatigue condition of a user; a user information acquisition unit that acquires user information including information obtained from the body or motion of the user; a user condition information generation unit that generates user condition information on the basis of the information acquired from the body or motion; a solution determination unit that determines, out of the multiple solutions, a solution according to the user condition information; and a solution provision unit that provides the determined solution to the user.
A61M 21/02 - Other devices or methods to cause a change in the state of consciousnessDevices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
The object is to provide a skin whitening agent having an excellent skin whitening effect. A compound expressed by the following Formula (1), or an acid addition salt thereof is used as an active ingredient of the skin whitening agent:
2 represents a hydrogen atom or an optionally branched acyl group having 1 to 6 carbon atoms.
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
Goods & Services
Chemicals for use in industry in the manufacture of personal care products, such as cosmetics, hair and skin care products; chemical preparations for use in the manufacture of cosmetics, hair and skin care products; active chemical ingredients for use in the manufacture of personal care products, namely, cosmetics, hair and skin care products; chemicals for use in industry, science, photography, agriculture, horticulture and forestry except fungicides, herbicides, insecticides and parasiticides; chemical additives for use in the manufacture of personal care products, such as cosmetics, hair and skin care products Cosmetics; cosmetic preparations for skin care; non-medicated soaps; soaps, namely, facial cleansers; toilet water; lotions for cosmetic purposes; skin moisturizers; skin whitening preparations; beauty serums; beauty masks
11.
External preparation for skin for wrinkle improvement
An oil-gel-form external preparation for skin contains a compound represented by the following General Formula (1), an isomer thereof, and/or a pharmaceutically acceptable salt thereof. A partially cross-linked methyl polysiloxane; allows easy penetration of the compound from the preparation into the skin while enhancing the percutaneous absorbability and improving the intradermal retentivity.
4 linear or branched alkyl group.
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61K 8/891 - Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
The present invention provides a method for screening a component that affects fluctuation of desmoglein and other adhesion proteins present in stratum corneum cells, the method being more accurate than conventional methods. A method for screening a component that affects fluctuation of adhesion proteins in stratum corneum cells, wherein the screening method comprises: a harvesting step for harvesting stratum corneum cells using a deep stripping technique; a transfer step for transferring the stratum corneum to a slide the surface of which has been positively charged; a cleansing step for cleansing the slide; an adjustment step for adding a sought component to the slide, dyeing adhesion proteins through an immune tissue dyeing technique, and adjusting a screening specimen; an image acquisition step for photographing a discretionary location on the screening specimen and obtaining an image for analysis; and an evaluation step for evaluating the effect of the sought component on fluctuation of the adhesion proteins, with the area of a dyed portion in the image for analysis being used as an indicator.
A first problem is to provide a novel technique for forming hyaluronan into particles. Further, a second problem is to provide a novel technique suitable for production of a composite particle containing an anionic polymer and a peptide.
Means for solving the first problem is a composite particle containing an anionic polymer, and a cationic polymer (except for chitosan) having a degree of cationization of 0.2 or more. Means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or less.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
The object is to provide a wrinkle improving agent having an excellent wrinkle improving effect. A compound expressed by the following Formulas (1) and/or (2) is used as an active ingredient of a wrinkle improving agent.
(In Formulas (1) and (2), R and R′ independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R″ represents an alkylene group having 1 to 3 carbon atoms, and n represents a number of 0 or 1.)
The object is to provide a wrinkle improving agent having an excellent wrinkle improving effect. A compound expressed by the following Formula (1), or an acid addition salt thereof is used as an active ingredient of a wrinkle improving agent.
2 represents a hydrogen atom, or an optionally branched acyl group having 1 to 6 carbon atoms.)
The present invention addresses the problem of providing a skin lightening agent that has an excellent skin lightening effect. An active ingredient of the skin lightening agent is a compound represented by general formula (1) or acid-addition salts thereof. (In the formula, X represents a C1-C2 alkylene group in which a hydrogen atom may be substituted by a methyl group; Y represents COOR122OR2; R1represents a hydrogen atom or a C1-C6 alkyl group which may be branched; and R2 represents a hydrogen atom or a C1-C6 acyl group which may be branched.)
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
18.
METHOD FOR SCREENING FOR COMPONENTS THAT IMPROVE CONDITION OF AGED OR HYPOXIC SKIN, AND METHOD FOR ESTIMATING OXYGEN LEVEL OF SUBDERMAL TISSUE OR FIBROSIS LEVEL OF SUBDERMAL ADIPOCYTES AS INDEX OF SUBDERMAL TISSUE VISCOELASTICITY
The first problem to be solved by the present invention is to provide a novel technique for screening for components that are effective in suppressing the deterioration of collagen structures in a subject. To solve the first problem, the present invention provides a method for screening for components that suppress the deterioration of collagen structures due to hypoxic conditions and/or aging, the method being characterized by using, as an index, the effectiveness in reducing increases in collagen fiber bundle formation when a test component is added to a collagen-containing composition in which cells are dispersed, and the composition is incubated in hypoxic conditions.
A first problem is to provide a novel technique for forming hyaluronan into particles. Further, a second problem is to provide a novel technique suitable for production of a composite particle containing an anionic polymer and a peptide.
Means for solving the first problem is a composite particle containing an anionic polymer, and a cationic polymer (except for chitosan) having a degree of cationization of 0.2 or more. Means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or less.
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61K 8/70 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing fluorine containing perfluoro groups, e.g. perfluoroethers
A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
The present invention addresses the problem of providing a skin lightening agent which has excellent skin lightening effect. According to the present invention, a skin lightening agent is configured to contain a compound represented by general formula (1) and/or a pharmacologically acceptable salt thereof as an active ingredient. (In general formula (1), each R independently represents a hydrogen atom, a methyl group or an ethyl group; and n represents an integer of 1-9.)
The present invention addresses the problem of providing a wrinkle ameliorating agent which has excellent wrinkle ameliorating effect. According to the present invention, a wrinkle ameliorating agent is configured to contain a compound represented by general formula (1) or an acid addition salt thereof as an active ingredient. (In the formula, X represents an alkylene group having 1-2 carbon atoms, wherein a hydrogen atom may be substituted by a methyl group; Y represents COOR1 or CH2OR2; R1 represents a hydrogen atom or an optionally branched alkyl group having 1-6 carbon atoms; and R2 represents a hydrogen atom or an optionally branched acyl group having 1-6 carbon atoms.)
The present invention addresses the problem of providing a wrinkle ameliorating agent which has excellent wrinkle ameliorating effect. According to the present invention, a wrinkle ameliorating agent is configured to contain a compound represented by general formula (1) and/or a compound represented by general formula (2) as an active ingredient. (In general formulae (1) and (2), each of R and R' independently represents a hydrogen atom or an alkyl group having 1-4 carbon atoms; R" represents an alkylene group having 1-3 carbon atoms; and n represents a number of 0 or 1.)
The present invention addresses the first problem of providing a novel technique for forming hyaluronan into particles. The present invention also addresses the second problem of providing a novel technique suited to the production of composite particles including an anionic polymer and a peptide. The means for solving the first problem is composite particles including an anionic polymer and a cationic polymer (excluding chitosan) having a degree of cationization of 0.2 or higher. The means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or lower.
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
01 - Chemical and biological materials for industrial, scientific and agricultural use
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
Goods & Services
Chemicals used in industry, science and photography; chemicals used in agriculture, horticulture and forestry, except fungicides, herbicides, insecticides and parasiticides; chemical preparations for use in the manufacture of cosmetics and hair care preparations not for medical purposes Cosmetics; Non-medicated skin care preparations; Cosmetic creams; Cosmetic soaps; Essential oils; Perfumery; Incense; Hair care preparations not for medical purposes
28.
EXTERNAL PREPARATION FOR SKIN FOR WRINKLE IMPROVEMENT
Provided is a method for improving the retention properties of a compound in the skin, which is effective for prevention of aging or improvement of the skin. An external preparation for the skin in an oil-gel form according to the present invention, which contains (1) a compound represented by general formula (1), an isomer thereof and/or a pharmacologically acceptable salt of the compound or isomer, and (2) a partially crosslinked methyl polysiloxane, enables easy migration of the above-described active ingredient (1) into the skin from the preparation, while enhancing the cutaneous absorption and improving the retention properties in the skin. (In the formula, R1 represents a linear or branched alkyl group having 1-4 carbon atoms and substituted by a carboxyl group, or a linear or branched alkyl group having 1-4 carbon atoms and substituted by a carboxylic acid ester group having an alkyl chain with 1-4 carbon atoms; and each of R2 and R3 independently represents a linear or branched alkyl group having 1-4 carbon atoms.)
The present invention provides an oil-in-water type emulsion composition which exhibits excellent temporal and temperature stability and produces a good feeling of use, and a method for producing same. Emulsification is carried out by means of a specific intermediate phase formed by mixing a surfactant able to form a L á phase, a surfactant able to form a H1 phase, and water. The intermediate phase preferably has an interfacial tension of 0.01-8 mN/m as a relative value with respect to poly(perfluoromethyl isopropyl ether). The oil-in-water type emulsion composition is produced by means of a production method that includes a step of adding an oil phase component and an aqueous phase component in that order to the intermediate phase. In addition, it is preferable to use a combination of a first surfactant and a second surfactant so that the viscosity of a mixed aqueous solution of the first and second surfactants is less than half of the sum of the viscosity values of individual aqueous solutions of the first and second surfactants having concentrations that are the same as the overall concentrations of the surfactants in the mixed aqueous solution.
B01J 13/00 - Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided forMaking microcapsules or microballoons
30.
Melanogenesis inhibitor comprising d-pantothenyl alcohol, and skin-whitening cosmetic containing same melanogenesis inhibitor
A61K 8/92 - Oils, fats or waxesDerivatives thereof, e.g. hydrogenation products
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
The present invention addresses the problem of providing a novel copolymer having an elastic feeling. A copolymer having a weight-average molecular weight of 20,000-110,000, having one or more types of constituent units (a) derived from a hydrophobic monomer having a specific structure, and one or more types of constituent units (b) derived from a hydrophilic monomer represented by general formula (2) as essential constituent units.
C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
Provided is a powder cosmetic which does not give a dry feeling in use and exhibits excellent moisturizing properties. This powder cosmetic contains, as an ingredient, a powder composition which comprises an oil, a surfactant and a powder base and which is characterized in that the surface of the powder base is composited with a lamellar phase comprising the surfactant as the main component.
A61K 8/55 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing phosphorus
A61K 8/891 - Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
A61K 8/894 - Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
A61Q 1/12 - Face or body powders, e.g. for grooming, adorning or absorbing
34.
Titania fine-particle composite and compositions containing the titania fine-particle composite
Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet-absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surface of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
An external preparation for skin is provided for amelioration of pigmentation. The skin preparation includes a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof:
3 represents a hydrogen atom or a linear chain or branched chain alkyl group having 1 to 4 carbon atoms.
A61K 8/44 - Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfurSalts, esters or N-acylated derivatives thereof
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
C07C 233/63 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
C07C 233/83 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
C07C 235/52 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
A61K 31/223 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-amino acids
36.
REVERSE VESICLE COMPOSITION AND METHOD FOR PRODUCING SAME
The present invention addresses the problem of providing a stable reverse vesicle composition using lecithin. The means for solving this problem is a reverse vesicle composition comprising a reverse vesicle including lecithin and an oil solution that has a molecular weight greater than 114 g/mol and is liquid at 25°C.
A61K 8/55 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing phosphorus
A61K 8/894 - Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
A61Q 1/12 - Face or body powders, e.g. for grooming, adorning or absorbing
A61Q 17/04 - Topical preparations for affording protection against sunlight or other radiationTopical sun tanning preparations
The purpose of the present invention is to provide a method for diagnosing skin condition with which the correlation between the papillary layer and skin condition can be made clear and skin condition can be estimated easily, precisely, and non-invasively. Skin condition is diagnosed by estimating skin condition using papillary layer structural information as the indicator.
The purpose of the present invention is to provide: a method for encapsulating a cell that can be produced easily even by salespersons in booths in department stores or shops or on the cosmetic user's premises and can be used for the observation under a phase-contrast microscope; and a method for observing a cell using a phase-contrast microscope. A cell encapsulation method for use in the observation under a phase-contrast microscope, said method being characterized by comprising placing the cell between an adhesive layer of a transparent adhesive tape and an adhesive layer of another transparent adhesive tape and then adhering the cell with the adhesive layers of the two adhesive tapes in a state sandwiched between the adhesive layers.
[Problem] The invention addresses the problem of providing a novel technique for easily estimating a sebum amount. [Solution] A subject's pore visual characteristic amount and age are applied to a previously prepared formula or model indicative of the correlation between a sebum amount and the pore visual characteristic amount and age, to calculate an estimated sebum amount for the subject.
Disclosed are novel techniques for high-precision sex determination and age estimation using facial images. The disclosed age estimation method includes: a step in which facial image data of a subject is acquired; a step in which spatial frequency intensities are calculated from the acquired facial image data; and a step in which the estimated age of the subject is calculated by applying the calculated spatial frequency intensities obtained from the facial image data.
An object of the present invention is to provide a prophylactic or ameliorating agent for pigmentation having a novel scaffold and an external preparation for skin containing the same as a component. The object is achieved by providing a prophylactic or ameliorating agent for pigmentation comprising a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof and an external preparation for skin containing the same as a component:
3 represents a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 15 carbon atoms; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
A61K 9/00 - Medicinal preparations characterised by special physical form
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
C07C 309/18 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing carboxyl groups bound to the carbon skeleton containing amino groups bound to the same carbon skeleton
INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES (Japan)
POLA CHEMICAL INDUSTRIES, INC. (Japan)
Inventor
Tominaga, Makoto
Sokabe, Takaaki
Kida, Naoko
Oba, Ai
Kanamaru, Akiko
Fukuda, Toshiyuki
Abstract
The purpose of the present invention is to provide a novel TRPV receptor activator which is suitable for the improvement in a skin barrier function. The purpose can be achieved by providing a TRPV receptor activator which comprises at least one compound selected from compounds respectively represented by the formulae or a plant extract containing the at least one compound in an effective amount for acting as a TRPV receptor activator. (In the formulae, a hydroxy group may be substituted by a methoxy group or an ethoxy group; and a methoxy group may be substituted by a hydroxy group or an ethoxy group.)
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 31/7042 - Compounds having saccharide radicals and heterocyclic rings
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Disclosed are novel techniques for gender determination and high-precision age estimation using face images. The disclosed age estimation method includes: a step in which face-image data of a subject is acquired; a step in which spatial-frequency intensities are computed from the acquired face-image data; and a step in which the estimated age of the subject is computed by applying the computed spatial-frequency intensities to a pre-prepared model or formula representing the correlation between age and spatial-frequency intensities obtained from face-image data.
4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2].
A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
A61K 8/44 - Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfurSalts, esters or N-acylated derivatives thereof
C07C 321/14 - Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
C07C 309/04 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
C07C 309/07 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
C07C 309/18 - Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing carboxyl groups bound to the carbon skeleton containing amino groups bound to the same carbon skeleton
1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
C07D 233/58 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
A61K 8/44 - Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfurSalts, esters or N-acylated derivatives thereof
C07D 207/404 - 2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07D 295/03 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
C07D 295/096 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Disclosed are: a pigmentation-ameliorating agent having a novel mother nucleus; and an external preparation for the skin, which comprises the pigmentation-ameliorating agent. Specifically disclosed are: a pigmentation-ameliorating agent comprising a compound represented by general formula (1) and/or a pharmacologically acceptable salt thereof, which has an excellent pigmentation-ameliorating activity; and an external preparation for the skin, which can be used for skin whitening purposes and comprises the pigmentation-ameliorating agent. (In the formula, R1 represents a linear or branched alkyl group having 1 to 6 carbon atoms; R2 represents a hydrogen atom, or a linear or branched alkyl group having 1 to 4 carbon atoms.)
Disclosed are: a pigmentation-preventing or -ameliorating agent having a novel base structure; and an external preparation for skin, which comprises the component. Specifically disclosed are: a pigmentation-preventing or -ameliorating agent comprising a compound represented by general formula (1) or an isomer and/or a pharmacologically acceptable salt thereof; and an external preparation for skin, which comprises the component. [In the formula, R1 represents a hydrogen atom, or a linear or branched alkyl group having 1 to 8 carbon atoms; R2 represents a hydrogen atom, or an aliphatic hydrocarbon group having 1 to 8 carbon atoms, an aromatic group having 5 to 12 carbon atoms, a polycyclic fused aromatic group or a heterocyclic group which is unsubstituted or has a substituent; R3 represents an aromatic group having 5 to 15 carbon atoms, a polycyclic fused aromatic group or a heterocyclic group which is unsubstituted or has a substituent; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
Disclosed is an external preparation for skin, which is suitable for the prevention or amelioration of pigmentation. Specifically disclosed are: a prophylactic or ameliorating agent for pigmentation, comprising a compound represented by general formula (1) or an isomer and/or a pharmacologically acceptable salt thereof; and an external preparation for skin, containing the component. [In the formula, R1 represents a unsubstituted aromatic group or an aromatic group having a substituent; R2 represents a hydrogen atom, a linear or branched C1-4 alkyl group, or an acyl group having a linear or branched C1-4 alkyl chain; and R3 represents a hydrogen atom, or a linear or branched C1-4 alkyl group.]
A61Q 19/02 - Preparations for care of the skin for chemically bleaching or whitening the skin
C07C 233/69 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
C07C 233/83 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
C07C 235/52 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
53.
Titania fine-particle composite and compositions containing the titania fine-particle composite
Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet-absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surface of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
A61K 8/39 - Derivatives containing from 2 to 10 oxyalkylene groups
A61K 8/81 - Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
A61Q 1/02 - Preparations containing skin colorants, e.g. pigments
54.
Vesicle useful for external preparation for skin, and external preparation for skin comprising the vesicle
10-30)acylglutamyl)lysine is preferably a lauroyl group. The ceramide or the derivative thereof is preferably ceramide type-2 or ceramide type-3. The vesicle can encapsulate an active ingredient. The vesicle can be contained in an external preparation for the skin.
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
A61K 8/68 - Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 8/39 - Derivatives containing from 2 to 10 oxyalkylene groups
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3’s present in the compound corresponds to the number of X’s and, when two or more R3’s are present, the R3’s are independently present and the adjacent two R3’s may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
A61K 31/085 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
A61K 31/135 - Amines, e.g. amantadine having aromatic rings, e.g. methadone
A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
A61K 31/40 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 31/4015 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 31/4409 - Non-condensed pyridinesHydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4453 - Non-condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
A61K 31/4545 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
C07D 207/404 - 2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
C07D 213/38 - Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
C07D 233/58 - Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
C07D 295/02 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
C07D 295/08 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
Provided are anti-wrinkle agents having a novel parent nucleus that are suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically permissible salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that occur as a result of photoaging due to ultraviolet ray exposure that is skin aging with increased age. [In the formula, R1 represents a hydrogen atom or a 1- to 8-carbon straight or branched alkyl group. R2 represents -SH, -SO3H, –S–S–X1, –S–X2, –SO–X3, –SO2–X4, –SO2–NY1–X5 or –SO2–NY2–Y3. X1‑X5 independently are hydrogen atoms or 1- to 8-carbon aliphatic hydrocarbon groups or 5- to 12-carbon aromatic parts wherein carbon atoms may be substituted with heteroatoms. Y1‑Y3 independently represent hydrogen atoms or 1- to 8-carbon straight or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1- to 8-carbon straight or branched alkyl chain. R4 represents a 5- to 12-carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0‑3 and n represents an integer 1 or 2.]
A technique for judging the skin texture of a person and/or the crease thereof quickly with high accuracy and a method for selecting a skin external medicine on the basis the result of the judgment are provided. A skin texture and/or crease judging method comprises a step of carrying out image processing of a captured skin image including cross binarization and/or short-line segment matching and thereby obtaining a physical quantity of the skin and a step of substituting the obtained physical quantity into a prepared prediction formula to obtain an evaluation value and thereby judging the difference between the obtained evaluation value and the evaluation value of the skin texture and/or crease. The skin texture and/or crease judging method realizes the technique and the selecting method.
Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet –absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surfaces of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
Disclosed is a technique for allowing an active ingredient as an agent for improving or maintaining the dermal environment to reach a dermis. Specifically disclosed is a vesicle comprising the following components 1) to 3): 1) an α,&egr;-bis(&ggr;-N-(C10-30)acylglutamyl)lysine and/or a salt thereof; 2) ceramide and/or a derivative thereof; and 3) one or more members selected from a glycerin fatty acid ester, a polyglycerin fatty acid ester and a pyroglutamic acid glycerin fatty acid ester. The acyl group in the α,&egr;-bis(&ggr;-N-(C10-30)acylglutamyl)lysine is preferably a lauroyl group. The ceramide or the derivative thereof is preferably ceramide type-2 or -3. The vesicle can enclose an active ingredient. The vesicle can be contained in an external preparation for the skin.
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
A61K 8/68 - Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
It is intended to provide a novel melanogenesis inhibitor which has a novel mother nucleus and can be added to a skin external preparation. More specifically, a melanogenesis inhibitor which contains a compound represented by the following general formula (A) or a pharmacologically acceptable salt thereof as the active ingredient. General formula (A) In the above general formula, Ra1 and Ra2 each independently represents a hydrogen atom or an alkyl group, and Ra3 represents an aromatic group.
A cosmetic raw material highly effective in removing a cosmetic makeup preparation which forms a tenacious cosmetic film having excellent long-lasting properties. A branched fatty acid ester of a polyhydric alcohol is provided which has a structure represented by the general formula (1). The branched fatty acid ester of a polyhydric alcohol preferably is propylene glycol di-2-ethylhexanoate, propylene glycol mono-2-ethylhexanoate, 1,3-butylene glycol di-2-ethylhexanoate, or 1,3-butylene glycol mono-2-ethylhexanoate. (In the formula, R1 and R2 each independently represents hydrogen or branched aliphatic C6-16 acyl, provided that at least one of R1 and R2 is branched aliphatic C6-16 acyl; and n and m each independently is an integer of 0-4, provided that m is equal to or smaller than n.)
C07C 69/28 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with dihydroxylic compounds
It is intended to provide a method whereby the skin conditions (for example, loss in the skin's elasticity, wrinkle formation possibility, insufficient unite in dermal collagen fiber bundles, etc.) can be exactly and conveniently assessed. It is also intended to provide a method whereby the wrinkle reducing effect of a test substance can be exactly and conveniently evaluated. The skin conditions are assessed by using the expression amount of an adhesion factor in skin cells as an indication. The wrinkle reducing effect of a test substance is evaluated by using the expression amount of an adhesion factor in skin cells in the presence of the test substance as an indication.
It is intended to provide a method of indicating an unstained image of horny layer cell or the like in an observable pseudocolor in the case of preparing a horny layer cell preparation, which is capable of providing information useful in differentiating horny layer cells or appropriately selecting a cosmetic, without resorting to staining the horny layer cell preparation. The state of skin horny layer cells is input into a computer as an enlarged image by using, for example, a digital microcsope. Then, the RGB values of the individual pixels in the image are converted with the use of a conversion system such as a conversion formula or a conversion chart and an image is indicated in a pseudocolor by using the individual RGB values thus converted.
It is intended to provide a method for conveniently and accurately evaluating the uniformity of application of an external preparation for skin. Further, it is intended to provide an external preparation for skin having high application uniformity by elucidating a relationship between the skin shape and the application uniformity of the external preparation for skin. By using the abundance of an external preparation for skin around the pores of the skin to which the external preparation for skin was applied as an index, the application uniformity of the external preparation for skin is evaluated. As the external preparation for skin obtained by the evaluation, for example, a cosmetic for making the pores less visible comprising translucent spherical powder, trimethylsiloxysilicate and/or an (alkyl acrylate/dimethicone)copolymer and water, wherein 90% by mass or more of the translucent spherical powder is translucent spherical powder with a particle diameter of 4 to 15 &mgr;m is preferably exemplified.
The present invention provides a technology for delivering a ceramide across the horny layer to sufficiently exert the effects of the ceramide. Specifically, the present invention provides a skin external preparation comprising a ceramide, which enables sufficient delivery of a ceramide comprised in the skin external preparation across the horny layer to near the dermis when the skin preparation is applied on the skin surface. A skin external preparation of the present invention comprises a ceramide, an organically modified clay mineral, a diester of N-acylglutamic acid, and a phytosterol as essential components and in the form of water-in-oil emulsion.
A61K 8/68 - Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
67.
METHOD OF EVALUATING SKIN BARRIER FUNCTION, METHOD OF SCREENING MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION USING THE EVALUATING METHOD, THE MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION, AND COSMETIC CONTAINING THE MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION
An object of the present invention is to provide a technology for developing an excellent material for enhancing skin barrier function and to provide a cosmetic which is developed based on the technology and has excellent ability to enhance the skin barrier function. The present invention relates to a method of evaluating skin barrier function, comprising: 1) culturing normal human epidermal cells in wells with a semipermeable membrane bottom; 2) adding a medium not containing metal ions to be measured to the above of cells in each well and a medium containing the metal ions to be measured to the below of the cells in each well, provided that the below is a side where the cells are adhered to the semipermeable membrane, and the above is an opposite side thereto, and culturing the cells under metal ion loaded condition; 3) measuring a concentration of the metal ions in each medium; and 4) calculating permeability of the metal ions in an epidermal cell layer based on the measured concentrations of the media to evaluate the skin barrier function.
Disclosed is an agent for external application to the skin which is hardly reduced in viscosity even when stored for a long period under extreme high temperature storage conditions and is therefore stable. The agent is of an emulsion-type, and comprises 1) an alginic acid polyhydric alcohol ester having an esterification degree ranging from 75 to 95% (e.g., alginic acid propylene glycol ester) and/or a salt thereof, 2) a polyvalent metal ion (e.g., a calcium ion); and 3) a 4-alkylresolcinol (e.g., 4-n-butylresolcinol) and/or a salt thereof.
Disclosed is a preparation for external application to skin, which contains a triterpenic acid typified by ursolic acid and the like. For obtaining a preparation for external application to skin having excellent storage stability by improving the dissolution stability of the triterpenic acid and the like, 4-alkylresorcinol such as 4-n-butylresorcinol is added into a preparation for external application to skin containing a triterpenic acid such as ursolic acid and the like.
It is intended to provide a technique which aims at conveniently and highly accurately selecting a cosmetic suitable for each user and a technique for designing such a cosmetic. More specifically speaking, it is intended to provide a novel indication for evaluating the suitability of a makeup cosmetic for the skin and a method of fully utilizing this indication. By using the difference between the surface free energy of a cosmetic and the surface free energy of the skin as an indication, the suitability level of a specific cosmetic for the skin is evaluated. Then, the composition of the cosmetic is determined so as to minimize the difference between the surface free energy of a cosmetic and the surface free energy of the skin.
Disclosed are: a novel skin-whitening agent; and a skin-whitening cosmetic or quasi-drug which is highly effective for prevention/amelioration of melanopathy and is prepared using the skin-whitening agent. The cosmetic comprises a compound represented by the general formula (I) and/or a salt thereof as an active ingredient. (I) wherein R1 and R2 independently represent a secondary or tertiary alkyl group having 3 to 7 carbon atoms; and R3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms.
To increase a tissue regeneration ability of a living body such as a collagen production ability of fibroblast in the dermis in a skin defect area typified by a large wrinkle or wound, a flavanone derivative such as farrerol is used as an active ingredient of an external preparation for skin. Further, to efficiently screen a substance having an excellent effect on promoting wound healing, the remodeling action of collagen fiber bundle is tested by using a skin wound model.
