The present invention addresses the problem of providing a new technology for producing, from stem cells, a layered three-dimensional skin tissue in which an epidermal layer and a dermal layer are laminated. The present invention, which solves the above problem, is a method for producing a three-dimensional skin tissue, the method comprising a skin tissue formation process for producing a three-dimensional skin tissue in which a dermal layer and an epidermal layer are laminated. The skin tissue formation process includes a three-dimensional culturing process for placing, on a membrane which is provided to a culturing vessel and through which a culture solution can permeate, a three-dimensionally cultured product obtained through suspension culturing of stem cells, without dissecting the same, and culturing the same to obtain a layered three-dimensional skin tissue in which at least a dermal layer and an epidermal layer are laminated.
The present invention addresses the problem of providing novel technology for easily culturing mesenchymal stem cells from removed hair. To solve this problem, the present invention is a method for culturing mesenchymal stem cells comprising a culturing step in which a hair that has been acquired by being pulled out and that contains a hair bulb covered by dermal hair root sheath tissue is cultured in culture broth.
The first problem addressed by the present invention is to provide a novel technology with which it is possible to produce iPS cells using epithelial cells such as keratinocytes. To solve the above problem, the present invention is a method for producing induced pluripotent stem cells using epithelial cells that comprises a reprogramming step that includes introducing into epithelial cells a reprogrammed gene or a translation product thereof that reprograms nuclei and an adherent culture step that cultures the cells that have undergone the reprogramming step on a culture surface coated with laminin or a fragment thereof.
This solution providing system comprises: a storing unit for storing information on multiple solutions for improving a user condition which is one or both of the emotion and fatigue condition of a user; a user information acquisition unit that acquires user information including information obtained from the body or motion of the user; a user condition information generation unit that generates user condition information on the basis of the information acquired from the body or motion; a solution determination unit that determines, out of the multiple solutions, a solution according to the user condition information; and a solution provision unit that provides the determined solution to the user.
A61M 21/02 - Autres dispositifs ou méthodes pour amener un changement dans l'état de conscienceDispositifs pour provoquer ou arrêter le sommeil par des moyens mécaniques, optiques ou acoustiques, p. ex. pour mettre en état d'hypnose pour provoquer le sommeil ou la relaxation, p. ex. par stimulation directe des nerfs, par hypnose ou par analgésie
G16H 20/30 - TIC spécialement adaptées aux thérapies ou aux plans d’amélioration de la santé, p. ex. pour manier les prescriptions, orienter la thérapie ou surveiller l’observance par les patients concernant des thérapies ou des activités physiques, p. ex. la physiothérapie, l’acupression ou les exercices
The object is to provide a skin whitening agent having an excellent skin whitening effect. A compound expressed by the following Formula (1), or an acid addition salt thereof is used as an active ingredient of the skin whitening agent:
2 represents a hydrogen atom or an optionally branched acyl group having 1 to 6 carbon atoms.
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
Produits et services
Chemicals for use in industry in the manufacture of personal care products, such as cosmetics, hair and skin care products; chemical preparations for use in the manufacture of cosmetics, hair and skin care products; active chemical ingredients for use in the manufacture of personal care products, namely, cosmetics, hair and skin care products; chemicals for use in industry, science, photography, agriculture, horticulture and forestry except fungicides, herbicides, insecticides and parasiticides; chemical additives for use in the manufacture of personal care products, such as cosmetics, hair and skin care products Cosmetics; cosmetic preparations for skin care; non-medicated soaps; soaps, namely, facial cleansers; toilet water; lotions for cosmetic purposes; skin moisturizers; skin whitening preparations; beauty serums; beauty masks
9.
External preparation for skin for wrinkle improvement
An oil-gel-form external preparation for skin contains a compound represented by the following General Formula (1), an isomer thereof, and/or a pharmaceutically acceptable salt thereof. A partially cross-linked methyl polysiloxane; allows easy penetration of the compound from the preparation into the skin while enhancing the percutaneous absorbability and improving the intradermal retentivity.
4 linear or branched alkyl group.
A61K 8/64 - ProtéinesPeptidesLeurs dérivés ou produits de dégradation
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
The present invention provides a method for screening a component that affects fluctuation of desmoglein and other adhesion proteins present in stratum corneum cells, the method being more accurate than conventional methods. A method for screening a component that affects fluctuation of adhesion proteins in stratum corneum cells, wherein the screening method comprises: a harvesting step for harvesting stratum corneum cells using a deep stripping technique; a transfer step for transferring the stratum corneum to a slide the surface of which has been positively charged; a cleansing step for cleansing the slide; an adjustment step for adding a sought component to the slide, dyeing adhesion proteins through an immune tissue dyeing technique, and adjusting a screening specimen; an image acquisition step for photographing a discretionary location on the screening specimen and obtaining an image for analysis; and an evaluation step for evaluating the effect of the sought component on fluctuation of the adhesion proteins, with the area of a dyed portion in the image for analysis being used as an indicator.
G01N 33/48 - Matériau biologique, p. ex. sang, urineHémocytomètres
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G01N 33/53 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet
11.
Composite particles including anionic polymer and cationic polymer or peptide, and method for producing composite particles
A first problem is to provide a novel technique for forming hyaluronan into particles. Further, a second problem is to provide a novel technique suitable for production of a composite particle containing an anionic polymer and a peptide.
Means for solving the first problem is a composite particle containing an anionic polymer, and a cationic polymer (except for chitosan) having a degree of cationization of 0.2 or more. Means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or less.
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
The object is to provide a wrinkle improving agent having an excellent wrinkle improving effect. A compound expressed by the following Formulas (1) and/or (2) is used as an active ingredient of a wrinkle improving agent.
(In Formulas (1) and (2), R and R′ independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R″ represents an alkylene group having 1 to 3 carbon atoms, and n represents a number of 0 or 1.)
A61K 8/368 - Acides carboxyliquesLeurs sels ou anhydrides dans lesquels le groupe carboxyle est directement lié aux atomes de carbone du cycle aromatique
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
The object is to provide a wrinkle improving agent having an excellent wrinkle improving effect. A compound expressed by the following Formula (1), or an acid addition salt thereof is used as an active ingredient of a wrinkle improving agent.
2 represents a hydrogen atom, or an optionally branched acyl group having 1 to 6 carbon atoms.)
The present invention addresses the problem of providing a skin lightening agent that has an excellent skin lightening effect. An active ingredient of the skin lightening agent is a compound represented by general formula (1) or acid-addition salts thereof. (In the formula, X represents a C1-C2 alkylene group in which a hydrogen atom may be substituted by a methyl group; Y represents COOR122OR2; R1represents a hydrogen atom or a C1-C6 alkyl group which may be branched; and R2 represents a hydrogen atom or a C1-C6 acyl group which may be branched.)
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
16.
METHOD FOR SCREENING FOR COMPONENTS THAT IMPROVE CONDITION OF AGED OR HYPOXIC SKIN, AND METHOD FOR ESTIMATING OXYGEN LEVEL OF SUBDERMAL TISSUE OR FIBROSIS LEVEL OF SUBDERMAL ADIPOCYTES AS INDEX OF SUBDERMAL TISSUE VISCOELASTICITY
The first problem to be solved by the present invention is to provide a novel technique for screening for components that are effective in suppressing the deterioration of collagen structures in a subject. To solve the first problem, the present invention provides a method for screening for components that suppress the deterioration of collagen structures due to hypoxic conditions and/or aging, the method being characterized by using, as an index, the effectiveness in reducing increases in collagen fiber bundle formation when a test component is added to a collagen-containing composition in which cells are dispersed, and the composition is incubated in hypoxic conditions.
A61K 36/36 - Caryophyllaceae (famille de l'œillet), p. ex. saponaire d'Orient ou saponaire
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
A61Q 19/00 - Préparations pour les soins de la peau
A61Q 19/08 - Préparations contre le vieillissement
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
17.
Composite particles including anionic polymer and cationic polymer or peptide, and method for producing composite particles
A first problem is to provide a novel technique for forming hyaluronan into particles. Further, a second problem is to provide a novel technique suitable for production of a composite particle containing an anionic polymer and a peptide.
Means for solving the first problem is a composite particle containing an anionic polymer, and a cationic polymer (except for chitosan) having a degree of cationization of 0.2 or more. Means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or less.
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
A61K 8/70 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du fluor contenant des groupes perfluorés, p. ex. perfluoroéthers
A61K 8/02 - Cosmétiques ou préparations similaires pour la toilette caractérisés par une forme physique particulière
The present invention addresses the problem of providing a skin lightening agent which has excellent skin lightening effect. According to the present invention, a skin lightening agent is configured to contain a compound represented by general formula (1) and/or a pharmacologically acceptable salt thereof as an active ingredient. (In general formula (1), each R independently represents a hydrogen atom, a methyl group or an ethyl group; and n represents an integer of 1-9.)
The present invention addresses the problem of providing a wrinkle ameliorating agent which has excellent wrinkle ameliorating effect. According to the present invention, a wrinkle ameliorating agent is configured to contain a compound represented by general formula (1) or an acid addition salt thereof as an active ingredient. (In the formula, X represents an alkylene group having 1-2 carbon atoms, wherein a hydrogen atom may be substituted by a methyl group; Y represents COOR1 or CH2OR2; R1 represents a hydrogen atom or an optionally branched alkyl group having 1-6 carbon atoms; and R2 represents a hydrogen atom or an optionally branched acyl group having 1-6 carbon atoms.)
The present invention addresses the problem of providing a wrinkle ameliorating agent which has excellent wrinkle ameliorating effect. According to the present invention, a wrinkle ameliorating agent is configured to contain a compound represented by general formula (1) and/or a compound represented by general formula (2) as an active ingredient. (In general formulae (1) and (2), each of R and R' independently represents a hydrogen atom or an alkyl group having 1-4 carbon atoms; R" represents an alkylene group having 1-3 carbon atoms; and n represents a number of 0 or 1.)
The present invention addresses the first problem of providing a novel technique for forming hyaluronan into particles. The present invention also addresses the second problem of providing a novel technique suited to the production of composite particles including an anionic polymer and a peptide. The means for solving the first problem is composite particles including an anionic polymer and a cationic polymer (excluding chitosan) having a degree of cationization of 0.2 or higher. The means for solving the second problem is to mix an anionic polymer and a peptide in an aqueous solvent having a pH of 5 or lower.
A61K 8/64 - ProtéinesPeptidesLeurs dérivés ou produits de dégradation
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
01 - Produits chimiques destinés à l'industrie, aux sciences ainsi qu'à l'agriculture
03 - Produits cosmétiques et préparations de toilette; préparations pour blanchir, nettoyer, polir et abraser.
Produits et services
Chemicals used in industry, science and photography; chemicals used in agriculture, horticulture and forestry, except fungicides, herbicides, insecticides and parasiticides; chemical preparations for use in the manufacture of cosmetics and hair care preparations not for medical purposes Cosmetics; Non-medicated skin care preparations; Cosmetic creams; Cosmetic soaps; Essential oils; Perfumery; Incense; Hair care preparations not for medical purposes
26.
EXTERNAL PREPARATION FOR SKIN FOR WRINKLE IMPROVEMENT
Provided is a method for improving the retention properties of a compound in the skin, which is effective for prevention of aging or improvement of the skin. An external preparation for the skin in an oil-gel form according to the present invention, which contains (1) a compound represented by general formula (1), an isomer thereof and/or a pharmacologically acceptable salt of the compound or isomer, and (2) a partially crosslinked methyl polysiloxane, enables easy migration of the above-described active ingredient (1) into the skin from the preparation, while enhancing the cutaneous absorption and improving the retention properties in the skin. (In the formula, R1 represents a linear or branched alkyl group having 1-4 carbon atoms and substituted by a carboxyl group, or a linear or branched alkyl group having 1-4 carbon atoms and substituted by a carboxylic acid ester group having an alkyl chain with 1-4 carbon atoms; and each of R2 and R3 independently represents a linear or branched alkyl group having 1-4 carbon atoms.)
The present invention provides an oil-in-water type emulsion composition which exhibits excellent temporal and temperature stability and produces a good feeling of use, and a method for producing same. Emulsification is carried out by means of a specific intermediate phase formed by mixing a surfactant able to form a L á phase, a surfactant able to form a H1 phase, and water. The intermediate phase preferably has an interfacial tension of 0.01-8 mN/m as a relative value with respect to poly(perfluoromethyl isopropyl ether). The oil-in-water type emulsion composition is produced by means of a production method that includes a step of adding an oil phase component and an aqueous phase component in that order to the intermediate phase. In addition, it is preferable to use a combination of a first surfactant and a second surfactant so that the viscosity of a mixed aqueous solution of the first and second surfactants is less than half of the sum of the viscosity values of individual aqueous solutions of the first and second surfactants having concentrations that are the same as the overall concentrations of the surfactants in the mixed aqueous solution.
A61K 8/33 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'oxygène
A61K 8/64 - ProtéinesPeptidesLeurs dérivés ou produits de dégradation
A61Q 19/00 - Préparations pour les soins de la peau
B01J 13/00 - Chimie des colloïdes, p. ex. production de substances colloïdales ou de leurs solutions, non prévue ailleursFabrication de microcapsules ou de microbilles
28.
Melanogenesis inhibitor comprising d-pantothenyl alcohol, and skin-whitening cosmetic containing same melanogenesis inhibitor
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
A61K 8/33 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'oxygène
A61K 8/92 - Huiles, graisses ou ciresLeurs dérivés, p. ex. produits d'hydrogénation
A61K 8/97 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base d’algues, de champignons, de lichens ou de plantesCosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de leurs dérivés
The present invention addresses the problem of providing a novel copolymer having an elastic feeling. A copolymer having a weight-average molecular weight of 20,000-110,000, having one or more types of constituent units (a) derived from a hydrophobic monomer having a specific structure, and one or more types of constituent units (b) derived from a hydrophilic monomer represented by general formula (2) as essential constituent units.
C08F 220/28 - Esters contenant de l'oxygène en plus de l'oxygène de la fonction carboxyle ne contenant pas de cycles aromatiques dans la partie alcool
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
A61Q 19/00 - Préparations pour les soins de la peau
30.
MELANOGENESIS INHIBITOR COMPRISING D-PANTOTHENYL ALCOHOL, AND SKIN-WHITENING COSMETIC CONTAINING SAME MELANOGENESIS INHIBITOR
Provided is a powder cosmetic which does not give a dry feeling in use and exhibits excellent moisturizing properties. This powder cosmetic contains, as an ingredient, a powder composition which comprises an oil, a surfactant and a powder base and which is characterized in that the surface of the powder base is composited with a lamellar phase comprising the surfactant as the main component.
A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
A61K 8/894 - Polysiloxanes saturés, p. ex. diméthicone, phényl triméthicone, C24-C28 méthicone, stéaryl diméthicone modifiés par un groupe polyoxyalkylène, p. ex. cétyl diméthicone copolyol
A61Q 1/12 - Poudres pour le visage ou le corps, p. ex. pour l'entretien, l'embellissement ou l'absorption
32.
Titania fine-particle composite and compositions containing the titania fine-particle composite
Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet-absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surface of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
An external preparation for skin is provided for amelioration of pigmentation. The skin preparation includes a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof:
3 represents a hydrogen atom or a linear chain or branched chain alkyl group having 1 to 4 carbon atoms.
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07C 233/63 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles autres que des cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des groupes carboxyle
C07C 233/83 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des groupes carboxyle avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique d'un squelette carboné acyclique saturé
C07C 235/52 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné avec des atomes de carbone de groupes carboxamide et des atomes d'oxygène, liés par des liaisons simples, liés à des atomes de carbone du même cycle aromatique à six chaînons non condensé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des groupes carboxyle
A61K 31/223 - Esters, p. ex. nitroglycérine, sélénocyanates d'acides carboxyliques d'acides acycliques, p. ex. pravastatine d'alpha-amino-acides
34.
REVERSE VESICLE COMPOSITION AND METHOD FOR PRODUCING SAME
The present invention addresses the problem of providing a stable reverse vesicle composition using lecithin. The means for solving this problem is a reverse vesicle composition comprising a reverse vesicle including lecithin and an oil solution that has a molecular weight greater than 114 g/mol and is liquid at 25°C.
A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
A61K 8/894 - Polysiloxanes saturés, p. ex. diméthicone, phényl triméthicone, C24-C28 méthicone, stéaryl diméthicone modifiés par un groupe polyoxyalkylène, p. ex. cétyl diméthicone copolyol
A61Q 1/12 - Poudres pour le visage ou le corps, p. ex. pour l'entretien, l'embellissement ou l'absorption
A61Q 17/04 - Préparations topiques pour faire écran au soleil ou aux radiationsPréparations topiques pour bronzer
A61Q 19/00 - Préparations pour les soins de la peau
35.
METHOD FOR DIAGNOSING SKIN CONDITION BASED ON PAPILLARY LAYER STRUCTURAL ANALYSIS
The purpose of the present invention is to provide a method for diagnosing skin condition with which the correlation between the papillary layer and skin condition can be made clear and skin condition can be estimated easily, precisely, and non-invasively. Skin condition is diagnosed by estimating skin condition using papillary layer structural information as the indicator.
The purpose of the present invention is to provide: a method for encapsulating a cell that can be produced easily even by salespersons in booths in department stores or shops or on the cosmetic user's premises and can be used for the observation under a phase-contrast microscope; and a method for observing a cell using a phase-contrast microscope. A cell encapsulation method for use in the observation under a phase-contrast microscope, said method being characterized by comprising placing the cell between an adhesive layer of a transparent adhesive tape and an adhesive layer of another transparent adhesive tape and then adhering the cell with the adhesive layers of the two adhesive tapes in a state sandwiched between the adhesive layers.
G02B 21/34 - Lames de microscope, p. ex. montage d'échantillons sur des lames de microscope
G01N 1/28 - Préparation d'échantillons pour l'analyse
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
G02B 21/14 - Condensateurs donnant un éclairage pour une observation en contraste de phase
[Problem] The invention addresses the problem of providing a novel technique for easily estimating a sebum amount. [Solution] A subject's pore visual characteristic amount and age are applied to a previously prepared formula or model indicative of the correlation between a sebum amount and the pore visual characteristic amount and age, to calculate an estimated sebum amount for the subject.
Disclosed are novel techniques for high-precision sex determination and age estimation using facial images. The disclosed age estimation method includes: a step in which facial image data of a subject is acquired; a step in which spatial frequency intensities are calculated from the acquired facial image data; and a step in which the estimated age of the subject is calculated by applying the calculated spatial frequency intensities obtained from the facial image data.
G06K 9/00 - Méthodes ou dispositions pour la lecture ou la reconnaissance de caractères imprimés ou écrits ou pour la reconnaissance de formes, p.ex. d'empreintes digitales
G06K 9/36 - Prétraitement de l'image, c. à d. traitement de l'information image sans se préoccuper de l'identité de l'image
An object of the present invention is to provide a prophylactic or ameliorating agent for pigmentation having a novel scaffold and an external preparation for skin containing the same as a component. The object is achieved by providing a prophylactic or ameliorating agent for pigmentation comprising a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof and an external preparation for skin containing the same as a component:
3 represents a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 15 carbon atoms; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
A61K 31/196 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino le groupe amino étant lié directement à un cycle, p. ex. acide anthranilique, acide méfénamique, diclofénac, chlorambucil
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07C 309/18 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé contenant des groupes carboxyle liés au squelette carboné contenant des groupes amino liés au même squelette carboné
INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCES (Japon)
POLA CHEMICAL INDUSTRIES, INC. (Japon)
Inventeur(s)
Tominaga, Makoto
Sokabe, Takaaki
Kida, Naoko
Oba, Ai
Kanamaru, Akiko
Fukuda, Toshiyuki
Abrégé
The purpose of the present invention is to provide a novel TRPV receptor activator which is suitable for the improvement in a skin barrier function. The purpose can be achieved by providing a TRPV receptor activator which comprises at least one compound selected from compounds respectively represented by the formulae or a plant extract containing the at least one compound in an effective amount for acting as a TRPV receptor activator. (In the formulae, a hydroxy group may be substituted by a methoxy group or an ethoxy group; and a methoxy group may be substituted by a hydroxy group or an ethoxy group.)
A61K 8/97 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base d’algues, de champignons, de lichens ou de plantesCosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de leurs dérivés
A61K 31/7042 - Composés ayant des radicaux saccharide et des hétérocycles
A61K 36/00 - Préparations médicinales de constitution indéterminée contenant du matériel provenant d'algues, de lichens, de champignons, ou de plantes, ou leurs dérivés, p. ex. médicaments traditionnels à base de plantes
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
A61Q 19/00 - Préparations pour les soins de la peau
C07H 17/08 - Hétérocycles d'au moins huit chaînons, p. ex. érythromycines
43.
AGE ESTIMATION METHOD AND GENDER DETERMINATION METHOD
Disclosed are novel techniques for gender determination and high-precision age estimation using face images. The disclosed age estimation method includes: a step in which face-image data of a subject is acquired; a step in which spatial-frequency intensities are computed from the acquired face-image data; and a step in which the estimated age of the subject is computed by applying the computed spatial-frequency intensities to a pre-prepared model or formula representing the correlation between age and spatial-frequency intensities obtained from face-image data.
4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2].
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
C07C 321/14 - Sulfures, hydropolysulfures ou polysulfures ayant des groupes thio liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé
C07C 309/04 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé contenant un seul groupe sulfo
C07C 309/07 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé contenant des atomes d'oxygène liés au squelette carboné
C07C 309/18 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé contenant des groupes carboxyle liés au squelette carboné contenant des groupes amino liés au même squelette carboné
A61Q 19/08 - Préparations contre le vieillissement
1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
C07D 401/06 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une chaîne carbonée contenant uniquement des atomes de carbone aliphatiques
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
C07D 207/404 - Pyrrolidines-2, 5 diones avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux autres atomes de carbone du cycle, p. ex. succinimide
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07D 213/38 - Radicaux substitués par des atomes d'azote liés par des liaisons simples comportant uniquement de l'hydrogène, ou des radicaux hydrocarbonés, liés à l'atome d'azote substituant
C07D 295/03 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus des hétéro-éléments du cycle ne contenant qu'un hétérocycle avec les atomes d'azote du cycle liés directement à des atomes de carbone acycliques
C07D 295/096 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons simples avec les atomes d'azote du cycle et les atomes d'oxygène ou de soufre séparés par des carbocycles ou par des chaînes carbonées interrompues par des carbocycles
Disclosed are: a pigmentation-ameliorating agent having a novel mother nucleus; and an external preparation for the skin, which comprises the pigmentation-ameliorating agent. Specifically disclosed are: a pigmentation-ameliorating agent comprising a compound represented by general formula (1) and/or a pharmacologically acceptable salt thereof, which has an excellent pigmentation-ameliorating activity; and an external preparation for the skin, which can be used for skin whitening purposes and comprises the pigmentation-ameliorating agent. (In the formula, R1 represents a linear or branched alkyl group having 1 to 6 carbon atoms; R2 represents a hydrogen atom, or a linear or branched alkyl group having 1 to 4 carbon atoms.)
Disclosed are: a pigmentation-preventing or -ameliorating agent having a novel base structure; and an external preparation for skin, which comprises the component. Specifically disclosed are: a pigmentation-preventing or -ameliorating agent comprising a compound represented by general formula (1) or an isomer and/or a pharmacologically acceptable salt thereof; and an external preparation for skin, which comprises the component. [In the formula, R1 represents a hydrogen atom, or a linear or branched alkyl group having 1 to 8 carbon atoms; R2 represents a hydrogen atom, or an aliphatic hydrocarbon group having 1 to 8 carbon atoms, an aromatic group having 5 to 12 carbon atoms, a polycyclic fused aromatic group or a heterocyclic group which is unsubstituted or has a substituent; R3 represents an aromatic group having 5 to 15 carbon atoms, a polycyclic fused aromatic group or a heterocyclic group which is unsubstituted or has a substituent; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
Disclosed is an external preparation for skin, which is suitable for the prevention or amelioration of pigmentation. Specifically disclosed are: a prophylactic or ameliorating agent for pigmentation, comprising a compound represented by general formula (1) or an isomer and/or a pharmacologically acceptable salt thereof; and an external preparation for skin, containing the component. [In the formula, R1 represents a unsubstituted aromatic group or an aromatic group having a substituent; R2 represents a hydrogen atom, a linear or branched C1-4 alkyl group, or an acyl group having a linear or branched C1-4 alkyl chain; and R3 represents a hydrogen atom, or a linear or branched C1-4 alkyl group.]
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07C 233/69 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique d'un squelette carboné acyclique saturé
C07C 233/83 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des groupes carboxyle avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique d'un squelette carboné acyclique saturé
C07C 235/52 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné avec des atomes de carbone de groupes carboxamide et des atomes d'oxygène, liés par des liaisons simples, liés à des atomes de carbone du même cycle aromatique à six chaînons non condensé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des groupes carboxyle
51.
Titania fine-particle composite and compositions containing the titania fine-particle composite
Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet-absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surface of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
A61K 8/39 - Dérivés contenant 2 à 10 groupes oxyalkylène
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
A61Q 1/02 - Préparations contenant des colorants cutanés, p. ex. pigments
52.
Vesicle useful for external preparation for skin, and external preparation for skin comprising the vesicle
10-30)acylglutamyl)lysine is preferably a lauroyl group. The ceramide or the derivative thereof is preferably ceramide type-2 or ceramide type-3. The vesicle can encapsulate an active ingredient. The vesicle can be contained in an external preparation for the skin.
A61K 9/127 - Vecteurs à bicouches synthétiques, p. ex. liposomes ou liposomes comportant du cholestérol en tant qu’unique agent tensioactif non phosphatidylique
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 36/00 - Préparations médicinales de constitution indéterminée contenant du matériel provenant d'algues, de lichens, de champignons, ou de plantes, ou leurs dérivés, p. ex. médicaments traditionnels à base de plantes
A61K 8/68 - Sphingolipides, p. ex. céramides, cérébrosides, gangliosides
A61Q 19/00 - Préparations pour les soins de la peau
A61K 8/97 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base d’algues, de champignons, de lichens ou de plantesCosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de leurs dérivés
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61K 8/39 - Dérivés contenant 2 à 10 groupes oxyalkylène
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
A61K 8/368 - Acides carboxyliquesLeurs sels ou anhydrides dans lesquels le groupe carboxyle est directement lié aux atomes de carbone du cycle aromatique
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3’s present in the compound corresponds to the number of X’s and, when two or more R3’s are present, the R3’s are independently present and the adjacent two R3’s may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
A61K 31/085 - Éthers ou acétals ayant une liaison éther à un carbone cyclique d'un noyau aromatique
A61K 31/135 - Amines, p. ex. amantadine ayant des cycles aromatiques, p. ex. méthadone
A61K 31/137 - Arylalkylamines, p. ex. amphétamine, épinéphrine, salbutamol, éphédrine
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 31/40 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil
A61K 31/4015 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à cinq chaînons avec un azote comme seul hétéro-atome d'un cycle, p. ex. sulpiride, succinimide, tolmétine, buflomédil ayant des groupes oxo liés directement à l'hétérocycle, p. ex. piracétam, éthosuximide
A61K 31/4409 - Pyridines non condenséesLeurs dérivés hydrogénés substituées uniquement en position 4, p. ex. isoniazide, iproniazide
A61K 31/444 - Pyridines non condenséesLeurs dérivés hydrogénés contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. amrinone
A61K 31/4453 - Pipéridines non condensées, p. ex. pipérocaïne substituées uniquement en position 1, p. ex. propipocaïne, dipérodone
A61K 31/4545 - Pipéridines non condensées, p. ex. pipérocaïne contenant d'autres systèmes hétérocycliques contenant un cycle à six chaînons avec l'azote comme hétéro-atome du cycle, p. ex. pipampérone, anabasine
A61K 31/495 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec deux azote comme seuls hétéro-atomes d'un cycle, p. ex. pipérazine
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
A61K 8/40 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'azote
C07D 207/404 - Pyrrolidines-2, 5 diones avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés directement aux autres atomes de carbone du cycle, p. ex. succinimide
C07D 213/38 - Radicaux substitués par des atomes d'azote liés par des liaisons simples comportant uniquement de l'hydrogène, ou des radicaux hydrocarbonés, liés à l'atome d'azote substituant
C07D 233/58 - Composés hétérocycliques contenant des cycles diazole-1, 3 ou diazole-1, 3 hydrogéné, non condensés avec d'autres cycles comportant deux liaisons doubles entre chaînons cycliques ou entre chaînons cycliques et chaînons non cycliques avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes de carbone du cycle avec uniquement des atomes d'hydrogène ou des radicaux ne contenant que des atomes d'hydrogène et de carbone, liés aux atomes d'azote du cycle
C07D 295/02 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus des hétéro-éléments du cycle
C07D 295/08 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle avec des radicaux hydrocarbonés substitués liés aux atomes d'azote du cycle substitués par des atomes d'oxygène ou de soufre liés par des liaisons simples
Provided are anti-wrinkle agents having a novel parent nucleus that are suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), stereoisomers thereof, or pharmacologically permissible salts thereof. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that occur as a result of photoaging due to ultraviolet ray exposure that is skin aging with increased age. [In the formula, R1 represents a hydrogen atom or a 1- to 8-carbon straight or branched alkyl group. R2 represents -SH, -SO3H, –S–S–X1, –S–X2, –SO–X3, –SO2–X4, –SO2–NY1–X5 or –SO2–NY2–Y3. X1‑X5 independently are hydrogen atoms or 1- to 8-carbon aliphatic hydrocarbon groups or 5- to 12-carbon aromatic parts wherein carbon atoms may be substituted with heteroatoms. Y1‑Y3 independently represent hydrogen atoms or 1- to 8-carbon straight or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1- to 8-carbon straight or branched alkyl chain. R4 represents a 5- to 12-carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0‑3 and n represents an integer 1 or 2.]
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61Q 19/08 - Préparations contre le vieillissement
55.
METHOD FOR AUTOMATICALLY JUDGING SKIN TEXTURE AND/OR CREASE
A technique for judging the skin texture of a person and/or the crease thereof quickly with high accuracy and a method for selecting a skin external medicine on the basis the result of the judgment are provided. A skin texture and/or crease judging method comprises a step of carrying out image processing of a captured skin image including cross binarization and/or short-line segment matching and thereby obtaining a physical quantity of the skin and a step of substituting the obtained physical quantity into a prepared prediction formula to obtain an evaluation value and thereby judging the difference between the obtained evaluation value and the evaluation value of the skin texture and/or crease. The skin texture and/or crease judging method realizes the technique and the selecting method.
Provided are a novel titania fine-particle composite which has high transparency, high stability, and high ultraviolet –absorbing power and excellent redispersibility, and skin-care external preparations which contain the titania fine-particle composite and exert high ultraviolet protective effect. The titania fine-particle composite can be produced by adding one or more selected from among carboxylic acids and carboxylic acid derivatives represented by general formula (1), and polymers containing the carboxylic acids or carboxylic acid derivatives as a constituent monomer to an aqueous acid dispersion of titania fine particles, and neutralizing the resulting dispersion with an alkali to form a titania fine-particle composite composed of titania fine particles functioning as cores and the carboxylic monomer or polymer deposited on the surfaces of the cores. In the titania fine-particle composite, titania fine particles functioning as cores have a high degree of crystallization and the intermolecular interaction between titania fine particles and the carboxylic monomer or polymer is strong. Therefore, the titania fine-particle composite can be uniformly dispersed in a dispersion medium to attain high transparency and high stability. Further, skin-care external preparations which exert high ultraviolet protective effect can be produced by adding the titania fine-particle composite.
Disclosed is a technique for allowing an active ingredient as an agent for improving or maintaining the dermal environment to reach a dermis. Specifically disclosed is a vesicle comprising the following components 1) to 3): 1) an α,&egr;-bis(&ggr;-N-(C10-30)acylglutamyl)lysine and/or a salt thereof; 2) ceramide and/or a derivative thereof; and 3) one or more members selected from a glycerin fatty acid ester, a polyglycerin fatty acid ester and a pyroglutamic acid glycerin fatty acid ester. The acyl group in the α,&egr;-bis(&ggr;-N-(C10-30)acylglutamyl)lysine is preferably a lauroyl group. The ceramide or the derivative thereof is preferably ceramide type-2 or -3. The vesicle can enclose an active ingredient. The vesicle can be contained in an external preparation for the skin.
A61K 8/64 - ProtéinesPeptidesLeurs dérivés ou produits de dégradation
A61K 8/68 - Sphingolipides, p. ex. céramides, cérébrosides, gangliosides
A61K 8/97 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base d’algues, de champignons, de lichens ou de plantesCosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de leurs dérivés
A61K 8/98 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés d'origine animale
A61K 31/164 - Amides, p. ex. acides hydroxamiques d'un acide carboxylique avec un aminoalcool, p. ex. céramides
A61K 31/19 - Acides carboxyliques, p. ex. acide valproïque
A61K 31/352 - Composés hétérocycliques ayant l'oxygène comme seul hétéro-atome d'un cycle, p. ex. fungichromine ayant des cycles à six chaînons avec un oxygène comme seul hétéro-atome d'un cycle condensés avec des carbocycles, p. ex. cannabinols, méthanthéline
A61K 31/56 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes
A61K 31/7048 - Composés ayant des radicaux saccharide et des hétérocycles ayant l'oxygène comme hétéro-atome d'un cycle, p. ex. leucoglucosane, hespéridine, érythromycine, nystatine
It is intended to provide a novel melanogenesis inhibitor which has a novel mother nucleus and can be added to a skin external preparation. More specifically, a melanogenesis inhibitor which contains a compound represented by the following general formula (A) or a pharmacologically acceptable salt thereof as the active ingredient. General formula (A) In the above general formula, Ra1 and Ra2 each independently represents a hydrogen atom or an alkyl group, and Ra3 represents an aromatic group.
A61K 8/35 - Cétones, p. ex. quinones, benzophénone
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07C 49/83 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes hydroxyle polycycliques
C07C 49/84 - Cétones comportant un groupe cétone lié à un cycle aromatique à six chaînons contenant des groupes éther, des groupes , des groupes ou des groupes
A cosmetic raw material highly effective in removing a cosmetic makeup preparation which forms a tenacious cosmetic film having excellent long-lasting properties. A branched fatty acid ester of a polyhydric alcohol is provided which has a structure represented by the general formula (1). The branched fatty acid ester of a polyhydric alcohol preferably is propylene glycol di-2-ethylhexanoate, propylene glycol mono-2-ethylhexanoate, 1,3-butylene glycol di-2-ethylhexanoate, or 1,3-butylene glycol mono-2-ethylhexanoate. (In the formula, R1 and R2 each independently represents hydrogen or branched aliphatic C6-16 acyl, provided that at least one of R1 and R2 is branched aliphatic C6-16 acyl; and n and m each independently is an integer of 0-4, provided that m is equal to or smaller than n.)
C07C 69/28 - Esters d'acides acycliques monocarboxyliques saturés dont le groupe carboxyle est lié à un atome de carbone acyclique ou à l'hydrogène avec au moins trois atomes de carbone dans la partie acide estérifiés par des composés dihydroxylés
It is intended to provide a method whereby the skin conditions (for example, loss in the skin's elasticity, wrinkle formation possibility, insufficient unite in dermal collagen fiber bundles, etc.) can be exactly and conveniently assessed. It is also intended to provide a method whereby the wrinkle reducing effect of a test substance can be exactly and conveniently evaluated. The skin conditions are assessed by using the expression amount of an adhesion factor in skin cells as an indication. The wrinkle reducing effect of a test substance is evaluated by using the expression amount of an adhesion factor in skin cells in the presence of the test substance as an indication.
C12Q 1/68 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des acides nucléiques
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
62.
METHOD OF SUPPORTING THE DIFFERENTIATION OF HORNY LAYER CELLS
It is intended to provide a method of indicating an unstained image of horny layer cell or the like in an observable pseudocolor in the case of preparing a horny layer cell preparation, which is capable of providing information useful in differentiating horny layer cells or appropriately selecting a cosmetic, without resorting to staining the horny layer cell preparation. The state of skin horny layer cells is input into a computer as an enlarged image by using, for example, a digital microcsope. Then, the RGB values of the individual pixels in the image are converted with the use of a conversion system such as a conversion formula or a conversion chart and an image is indicated in a pseudocolor by using the individual RGB values thus converted.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
63.
METHOD FOR EVALUATING EXTERNAL PREPARATION FOR SKIN AND EXTERNAL PREPARATION FOR SKIN
It is intended to provide a method for conveniently and accurately evaluating the uniformity of application of an external preparation for skin. Further, it is intended to provide an external preparation for skin having high application uniformity by elucidating a relationship between the skin shape and the application uniformity of the external preparation for skin. By using the abundance of an external preparation for skin around the pores of the skin to which the external preparation for skin was applied as an index, the application uniformity of the external preparation for skin is evaluated. As the external preparation for skin obtained by the evaluation, for example, a cosmetic for making the pores less visible comprising translucent spherical powder, trimethylsiloxysilicate and/or an (alkyl acrylate/dimethicone)copolymer and water, wherein 90% by mass or more of the translucent spherical powder is translucent spherical powder with a particle diameter of 4 to 15 &mgr;m is preferably exemplified.
The present invention provides a technology for delivering a ceramide across the horny layer to sufficiently exert the effects of the ceramide. Specifically, the present invention provides a skin external preparation comprising a ceramide, which enables sufficient delivery of a ceramide comprised in the skin external preparation across the horny layer to near the dermis when the skin preparation is applied on the skin surface. A skin external preparation of the present invention comprises a ceramide, an organically modified clay mineral, a diester of N-acylglutamic acid, and a phytosterol as essential components and in the form of water-in-oil emulsion.
A61K 8/68 - Sphingolipides, p. ex. céramides, cérébrosides, gangliosides
65.
METHOD OF EVALUATING SKIN BARRIER FUNCTION, METHOD OF SCREENING MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION USING THE EVALUATING METHOD, THE MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION, AND COSMETIC CONTAINING THE MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION
An object of the present invention is to provide a technology for developing an excellent material for enhancing skin barrier function and to provide a cosmetic which is developed based on the technology and has excellent ability to enhance the skin barrier function. The present invention relates to a method of evaluating skin barrier function, comprising: 1) culturing normal human epidermal cells in wells with a semipermeable membrane bottom; 2) adding a medium not containing metal ions to be measured to the above of cells in each well and a medium containing the metal ions to be measured to the below of the cells in each well, provided that the below is a side where the cells are adhered to the semipermeable membrane, and the above is an opposite side thereto, and culturing the cells under metal ion loaded condition; 3) measuring a concentration of the metal ions in each medium; and 4) calculating permeability of the metal ions in an epidermal cell layer based on the measured concentrations of the media to evaluate the skin barrier function.
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
66.
AGENT FOR EXTERNAL APPLICATION TO THE SKIN HAVING EXCELLENT STABILITY
Disclosed is an agent for external application to the skin which is hardly reduced in viscosity even when stored for a long period under extreme high temperature storage conditions and is therefore stable. The agent is of an emulsion-type, and comprises 1) an alginic acid polyhydric alcohol ester having an esterification degree ranging from 75 to 95% (e.g., alginic acid propylene glycol ester) and/or a salt thereof, 2) a polyvalent metal ion (e.g., a calcium ion); and 3) a 4-alkylresolcinol (e.g., 4-n-butylresolcinol) and/or a salt thereof.
Disclosed is a preparation for external application to skin, which contains a triterpenic acid typified by ursolic acid and the like. For obtaining a preparation for external application to skin having excellent storage stability by improving the dissolution stability of the triterpenic acid and the like, 4-alkylresorcinol such as 4-n-butylresorcinol is added into a preparation for external application to skin containing a triterpenic acid such as ursolic acid and the like.
A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
A61Q 19/00 - Préparations pour les soins de la peau
It is intended to provide a technique which aims at conveniently and highly accurately selecting a cosmetic suitable for each user and a technique for designing such a cosmetic. More specifically speaking, it is intended to provide a novel indication for evaluating the suitability of a makeup cosmetic for the skin and a method of fully utilizing this indication. By using the difference between the surface free energy of a cosmetic and the surface free energy of the skin as an indication, the suitability level of a specific cosmetic for the skin is evaluated. Then, the composition of the cosmetic is determined so as to minimize the difference between the surface free energy of a cosmetic and the surface free energy of the skin.
Disclosed are: a novel skin-whitening agent; and a skin-whitening cosmetic or quasi-drug which is highly effective for prevention/amelioration of melanopathy and is prepared using the skin-whitening agent. The cosmetic comprises a compound represented by the general formula (I) and/or a salt thereof as an active ingredient. (I) wherein R1 and R2 independently represent a secondary or tertiary alkyl group having 3 to 7 carbon atoms; and R3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or an alkoxy group having 1 to 4 carbon atoms.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/381 - Composés hétérocycliques ayant le soufre comme hétéro-atome d'un cycle ayant des cycles à cinq chaînons
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61P 43/00 - Médicaments pour des utilisations spécifiques, non prévus dans les groupes
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07D 333/22 - Radicaux substitués par des hétéro-atomes liés par une liaison double ou par deux hétéro-atomes, autres que des halogènes, liés au même atome de carbone par des liaisons simples
70.
EXTERNAL PREPARATION FOR SKIN CONTAINING FLAVANONE DERIVATIVE
To increase a tissue regeneration ability of a living body such as a collagen production ability of fibroblast in the dermis in a skin defect area typified by a large wrinkle or wound, a flavanone derivative such as farrerol is used as an active ingredient of an external preparation for skin. Further, to efficiently screen a substance having an excellent effect on promoting wound healing, the remodeling action of collagen fiber bundle is tested by using a skin wound model.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/353 - 3,4-Dihydrobenzopyranes, p. ex. chromane, catéchine
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61Q 19/08 - Préparations contre le vieillissement
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
71.
ORGANIC INORGANIC COMPOSITE POWDER, PROCESS FOR PRODUCING THE SAME AND COMPOSITION CONTAINING THE POWDER
An organic inorganic composite powder that has a specified particulate form corresponding to washing solvent and that contains fine inorganic particles, having high dispersibility in water. The organic inorganic composite powder is obtained through a process comprising dissolving a metal salt in a reaction solvent; carrying out neutralization or reduction in the presence of a monomer or polymer dissolved in the reaction solvent so as to attain precipitation from the reaction solvent, provided that when the monomer does not combine with the metal salt at the precipitation in the presence of a monomer, the monomer is polymerized after the precipitation of the metal salt; washing the obtained precipitate with a specified washing solvent; and drying the washed precipitate.
C09C 3/08 - Traitement par des composés organiques de bas poids moléculaire
A61K 8/19 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés inorganiques
A61K 8/36 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 8/81 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons insaturées carbone-carbone
A61Q 19/00 - Préparations pour les soins de la peau
C08K 5/09 - Acides carboxyliquesLeurs sels métalliquesLeurs anhydrides
C08K 9/04 - Ingrédients traités par des substances organiques
C08L 33/00 - Compositions contenant des homopolymères ou des copolymères de composés possédant un ou plusieurs radicaux aliphatiques non saturés, chacun ne contenant qu'une seule liaison double carbone-carbone et un seul étant terminé par un seul radical carboxyle, ou ses sels, anhydrides, esters, amides, imides ou nitrilesCompositions contenant des dérivés de tels polymères
C09C 1/00 - Traitement de substances inorganiques particulières, autres que des charges fibreuses Préparation du noir de carbone
To increase a tissue regeneration ability of a living body such as a collagen production ability of fibroblast in the dermis in a skin defect area typified by a large wrinkle or wound, a flavanone derivative such as farrerol is used as an active ingredient of an external preparation for skin. Further, to efficiently screen a substance having an excellent effect on promoting wound healing, the remodeling action of collagen fiber bundle is tested by using a skin wound model.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 31/353 - 3,4-Dihydrobenzopyranes, p. ex. chromane, catéchine
A61P 17/16 - Émollients ou protecteurs, p. ex. contre les radiations
A61Q 19/08 - Préparations contre le vieillissement
C12Q 1/02 - Procédés de mesure ou de test faisant intervenir des enzymes, des acides nucléiques ou des micro-organismesCompositions à cet effetProcédés pour préparer ces compositions faisant intervenir des micro-organismes viables
Disclosed is an external preparation for skin, which is suitable for the prevention or amelioration of pigmentation. Specifically disclosed are: a prophylactic or ameliorating agent for pigmentation, comprising a compound represented by general formula (1) or an isomer and/or a pharmacologically acceptable salt thereof; and an external preparation for skin, containing the component. [In the formula, R1 represents a unsubstituted aromatic group or an aromatic group having a substituent; R2 represents a hydrogen atom, a linear or branched C1-4 alkyl group, or an acyl group having a linear or branched C1-4 alkyl chain; and R3 represents a hydrogen atom, or a linear or branched C1-4 alkyl group.]
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61P 17/00 - Médicaments pour le traitement des troubles dermatologiques
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07C 233/69 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des atomes d'oxygène liés par des liaisons simples avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique d'un squelette carboné acyclique saturé
C07C 233/83 - Amides d'acides carboxyliques ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone d'un radical hydrocarboné substitué par des groupes carboxyle avec le radical hydrocarboné substitué lié à l'atome d'azote du groupe carboxamide par un atome de carbone acyclique d'un squelette carboné acyclique saturé
C07C 235/52 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des atomes d'oxygène ayant des atomes de carbone de groupes carboxamide liés à des atomes de carbone de cycles aromatiques à six chaînons et des atomes d'oxygène, liés par des liaisons simples, liés au même squelette carboné avec des atomes de carbone de groupes carboxamide et des atomes d'oxygène, liés par des liaisons simples, liés à des atomes de carbone du même cycle aromatique à six chaînons non condensé ayant l'atome d'azote d'au moins un des groupes carboxamide lié à un atome de carbone acyclique d'un radical hydrocarboné substitué par des groupes carboxyle
76.
MELANOGENESIS INHIBITOR COMPRISING D-PANTOTHENYL ALCOHOL AND ONE OR MORE PLANT EXTRACTS, AND SKIN-WHITENING COSMETIC COMPRISING THE SAME
Provided is a new application for D-pantothenyl alcohol, that is, a melanogenesis inhibitor comprising the D-pantothenyl alcohol, and one or more plant extracts having a melanogenesis inhibitory action selected from the group consisting of Uncaria gambir extract and Echinacea angustifolia leaf extract.
A61K 8/97 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base d’algues, de champignons, de lichens ou de plantesCosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des produits de constitution indéterminée ou leurs dérivés à base de leurs dérivés
The present invention addresses the problem of providing a wrinkle ameliorating agent which has excellent wrinkle ameliorating effect. According to the present invention, a wrinkle ameliorating agent is configured to contain a compound represented by general formula (1) and/or a compound represented by general formula (2) as an active ingredient. (In general formulae (1) and (2), each of R and R' independently represents a hydrogen atom or an alkyl group having 1-4 carbon atoms; R" represents an alkylene group having 1-3 carbon atoms; and n represents a number of 0 or 1.)
Provided is a method for blending a compound effective in preventing or improving aging of the skin into a chemically stable composition. Also provided is a method for increasing the uniform dispersibility of the compound in the composition. A compound represented by general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt of these is dispersed in an oil agent having 0-2 hydroxyl groups to produce an oil-based composition, whereby decomposition of the compound is suppressed. A powder, solid fat, and/or semisolid fat is also included in the composition, whereby precipitation of the compound in the composition over time is suppressed. [In the formula, R1 represents a C1-4 linear or branched alkyl group substituted by a carboxyl group or a C1-4 linear or branched alkyl group substituted by a carboxylic acid ester group having a C1-4 alkyl chain, and R2 and R3 each independently represent a C1-4 linear or branched alkyl group.]
A61K 8/64 - ProtéinesPeptidesLeurs dérivés ou produits de dégradation
A61K 8/70 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du fluor contenant des groupes perfluorés, p. ex. perfluoroéthers
The present invention addresses the problem of providing a skin lightening agent that has an excellent skin lightening effect. An active ingredient of the skin lightening agent is a compound represented by general formula (1) or acid-addition salts thereof. (In the formula, X represents a C1-C2 alkylene group in which a hydrogen atom may be substituted by a methyl group; Y represents COOR1 or CH2OR2; R1 represents a hydrogen atom or a C1-C6 alkyl group which may be branched; and R2 represents a hydrogen atom or a C1-C6 acyl group which may be branched.)
Provided is a method for improving the retention properties of a compound in the skin, which is effective for prevention of aging or improvement of the skin. An external preparation for the skin in an oil-gel form according to the present invention, which contains (1) a compound represented by general formula (1), an isomer thereof and/or a pharmacologically acceptable salt of the compound or isomer, and (2) a partially crosslinked methyl polysiloxane, enables easy migration of the above-described active ingredient (1) into the skin from the preparation, while enhancing the cutaneous absorption and improving the retention properties in the skin. (In the formula, R1 represents a linear or branched alkyl group having 1-4 carbon atoms and substituted by a carboxyl group, or a linear or branched alkyl group having 1-4 carbon atoms and substituted by a carboxylic acid ester group having an alkyl chain with 1-4 carbon atoms; and each of R2 and R3 independently represents a linear or branched alkyl group having 1-4 carbon atoms.)
The object is to provide a wrinkle improving agent having an excellent wrinkle
improving effect. A compound expressed by the following Formula (1), or an acid addition salt thereof is used as an active ingredient of a wrinkle improving agent. (Wherein X represents an alkylene group having 1 to 2 carbon atoms in which a hydrogen atom may be substituted with a methyl group, Y represents COOR1 or CH2OR2, RI represents a hydrogen atom, or an optionally branched alkyl group having 1 to 6 carbon atoms, and R2 represents a hydrogen atom, or an optionally branched acyl group having 1 to 6 carbon atoms.) 33
The invention relates to skin-whitening cosmetics comprising (1) D-pantothenyl alcohol and (2) one or more skin-whitening agents selected from the group consisting of:(see Compound 45)(see compound 46)(see Compound 47)(see Compound 48)(see Compound 49)(see Compound 50)(see Compound 51)(see Compound 52)salts thereof, and to the use of the skin-whitening cosmetics.
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
The invention relates to skin-whitening cosmetics comprising (1) D-pantothenyl alcohol and (2) one or more skin-whitening agents selected from the group consisting of the following compounds and their salts:(see Compound 30)(see Compound 31)(see Compound 32)(see Compound 33)(see Compound 34)(see Compound 35)(see Compound 36)(see Compound 37)(see Compound 38)(see Compound 39)(see Compound 40)(see Compound 41)(see Compound 42)(see Compound 43)and (see Compound 44) The invention also relates to the useof D-pantothenyl alcohol and these compounds and their salts as skin-whitening cosmetics.
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61K 8/55 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du phosphore
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
Provided are anti-wrinkle agents having a novel scaffold that is suitable as components for external skin preparations such as cosmetics. The anti-wrinkle agents comprise compounds represented by general formula (1), (see formula 1) stereoisomers thereof, or pharmacologically acceptable salts thereof, wherein R1-R4, m and n are defined in the specification. Said anti-wrinkle agents have excellent efficacy in improving wrinkles and sagging that are caused by skin aging with increased age or occur as a result of photoaging due to ultraviolet rays exposure. [In the formula, R1 represents a hydrogen atom or a 1 to 8 carbon straight or branched alkyl group. R2 represents -SH, -SO3H, -S-S-X1, -S-X2, -SO-X3, -SO2-X4, -SO2-NY1-X5 or -SO2-NY2-Y3. X1-X5 independently are hydrogen atoms or 1 to 8 carbon aliphatic hydrocarbon groups or 5 to 12 carbon aromatic moiety wherein carbon atoms may be substituted with heteroatoms. Y1 to Y3 independently represent hydrogen atoms or 1 to 8 carbon linear or branched alkyl groups. R3 represents a hydrogen atom or acyl group having a 1 to 8 carbon straight or branched alkyl chain. R4 represents a 5 to 12 carbon aromatic group or polycyclic condensed aromatic group that may have unsubstituted or substituted groups. m represents an integer 0-3 and n represents an integer 1 or 2.]
A61K 8/44 - Acides aminocarboxyliques ou leurs dérivés, p. ex. acides aminocarboxyliques contenant du soufreLeurs sels, esters ou dérivés N-acylés
A61K 8/46 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant du soufre
A61Q 19/08 - Préparations contre le vieillissement
C07C 309/18 - Acides sulfoniques ayant des groupes sulfo liés à des atomes de carbone acycliques d'un squelette carboné acyclique saturé contenant des groupes carboxyle liés au squelette carboné contenant des groupes amino liés au même squelette carboné
Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3' s present in the compound corresponds to X and, when two or more R3' s are present, the R3' s are independently present and the adjacent two R3' s may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
A61K 8/33 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'oxygène
A61K 8/40 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant de l'azote
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
A61Q 19/00 - Préparations pour les soins de la peau
A61Q 19/02 - Préparations pour les soins de la peau pour décolorer ou blanchir la peau chimiquement
C07C 15/16 - Hydrocarbures polycycliques non condensés contenant au moins deux groupes phényle liés par un seul atome de carbone acyclique
C07C 33/24 - Alcools monohydroxyliques ne contenant que des cycles aromatiques à six chaînons dans la partie cyclique polycycliques sans système cyclique condensé
C07C 43/178 - Éthers non saturés contenant des groupes hydroxyle ou O-métal
C07C 211/27 - Composés contenant des groupes amino liés à un squelette carboné ayant des groupes amino liés à des atomes de carbone acycliques d'un squelette carboné non saturé contenant au moins un cycle aromatique à six chaînons ayant des groupes amino reliés au cycle aromatique à six chaînons par l'intermédiaire de chaînes carbonées saturées
C07C 215/08 - Composés contenant des groupes amino et hydroxy liés au même squelette carboné ayant des groupes hydroxy et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant saturé et acyclique avec un seul groupe hydroxy et un seul groupe amino liés au squelette carboné
C07C 217/10 - Composés contenant des groupes amino et hydroxy éthérifiés liés au même squelette carboné ayant des groupes hydroxy éthérifiés et des groupes amino liés à des atomes de carbone acycliques du même squelette carboné le squelette carboné étant acyclique et saturé ayant un seul groupe hydroxy éthérifié et un seul groupe amino liés au squelette carboné, qui n'est pas substitué par ailleurs l'atome d'oxygène du groupe hydroxy éthérifié étant lié de plus à un atome de carbone acyclique à un atome de carbone acyclique d'un radical hydrocarboné contenant des cycles aromatiques à six chaînons
C07D 295/03 - Composés hétérocycliques contenant des cycles polyméthylène imine d'au moins cinq chaînons, des cycles aza-3 bicyclo [3.2.2] nonane, piperazine, morpholine ou thiomorpholine, ne comportant que des atomes d'hydrogène liés directement aux atomes de carbone du cycle contenant uniquement des atomes d'hydrogène et de carbone en plus des hétéro-éléments du cycle ne contenant qu'un hétérocycle avec les atomes d'azote du cycle liés directement à des atomes de carbone acycliques
87.
PROPHYLACTIC OR AMELIORATING AGENT FOR PIGMENTATION
An object of the present invention is to provide a prophylactic or ameliorating agent for pigmentation having a novel scaffold and an external preparation for skin containing the same as a component. The object is achieved by providing a prophylactic or ameliorating agent for pigmentation comprising a compound represented by the following general formula (1), an isomer thereof, and/or a pharmacologically acceptable salt thereof and an external preparation for skin containing the same as a component:(see formula 1)[wherein R1 represents a hydrogen atom or a linear chain or branched alkyl group having 1 to 8 carbon atom(s); R2 represents a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 8 carbon atom(s), a substituted or unsubstituted aromatic group, a substituted or unsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 12 carbon atoms; R3 represents a substituted or unsubstituted aromatic group, a substituted orunsubstituted polycyclic fused aromatic group, or a substituted or unsubstituted heterocyclic group having a 5 to 15 carbon atoms; n represents an integer of 1 or 2; and m represents an integer of 0 to 3.]
The invention relates to skin-whitening cosmetics comprising D-pantothenyl alcohol and one or more skin-whitening agents selected from the group consisting of the following compounds and their salts: The invention also relates to the use of D-pantothenyl alcohol and these compounds and their salts for whitening skin.
A61K 8/49 - Cosmétiques ou préparations similaires pour la toilette caractérisés par la composition contenant des composés organiques contenant des composés hétérocycliques
