Abrégé

The invention described herein relates to methods and compositions for treatment of one or more symptoms of gluten intolerance and related conditions (e.g., celiac disease and gluten sensitivity) by administration of a pharmaceutical composition comprising one or more Nepenthes enzymes.

Classes IPC  ?

• A61K 38/43 - EnzymesProenzymesLeurs dérivés
• A61K 38/46 - Hydrolases (3)
• A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier

Abrégé

The invention described herein relates to methods and compositions for treatment of gluten intolerance and related conditions (e.g., celiac disease and gluten sensitivity), or inhibition of inflammation and/or immune response in the intestine due to antigenic food peptides, by administration of a pharmaceutical composition comprising one or more Nepenthes enzymes.

Classes IPC  ?

• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61J 1/03 - Récipients spécialement adaptés à des fins médicales ou pharmaceutiques pour pilules ou comprimés
• A61K 36/36 - Caryophyllaceae (famille de l'œillet), p. ex. saponaire d'Orient ou saponaire
• A61P 29/00 - Agents analgésiques, antipyrétiques ou anti-inflammatoires non centraux, p. ex. agents antirhumatismauxMédicaments anti-inflammatoires non stéroïdiens [AINS]
• A61P 37/06 - Immunosuppresseurs, p. ex. médicaments pour le traitement du rejet de greffe

Abrégé

Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease. Further provided herein are pharmaceutical compositions comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof to treat bacterial infections of the gastrointestinal tract, such as C. difficile or H. pylori. Further provided herein are compositions comprising recombinant nepenthesin I or nepenthesin II, or homologous proteins, and methods for making the same.

Classes IPC  ?

• C12N 9/50 - Protéinases
• A23L 1/29 - Modification de la qualité nutritive des aliments; Produits diététiques ( A23L 1/09 a priorité;substituts diététiques du sel A23L 1/22)
• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61P 1/14 - Eupeptiques, p. ex. acides, enzymes, orexigènes, antidyspeptiques, toniques, antiflatulants
• A61P 31/04 - Agents antibactériens

Abrégé

Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease.

Classes IPC  ?

• A61K 38/48 - Hydrolases (3) agissant sur des liaisons peptidiques (3.4)
• A61K 36/36 - Caryophyllaceae (famille de l'œillet), p. ex. saponaire d'Orient ou saponaire
• A61P 1/14 - Eupeptiques, p. ex. acides, enzymes, orexigènes, antidyspeptiques, toniques, antiflatulants