The present disclosure generally relates to carbon sequestration materials, and related systems, articles, and methods. In some embodiments, the carbon sequestration material comprises a gel. In some embodiments, the gel comprises a hydrophilic material, a thermo-responsive polymer, and a carbon dioxide capture medium. In accordance with some embodiments, the gel, when in the presence of water, is capable of sequestering and/or releasing gaseous carbon dioxide. In some embodiments, the gel has a relatively large sequestration capacity such that a relatively large amount of carbon dioxide per gram of gel can be sequestered by the gel. In some embodiments, the gel sequesters a surprisingly large amount of carbon dioxide when exposed to relatively humid conditions. In some embodiments, the gel releases an advantageous amount of gaseous carbon dioxide that was previously sequestered by the gel.
B01J 20/28 - Compositions absorbantes ou adsorbantes solides ou compositions facilitant la filtrationAbsorbants ou adsorbants pour la chromatographieProcédés pour leur préparation, régénération ou réactivation caractérisées par leur forme ou leurs propriétés physiques
Membranes and related systems and methods for separation of components in liquids are generally described. The membrane may include particles in a polymer matrix (e.g., a polyamide layer). The particles may include metal-organic framework particles comprising functional groups (e.g., from post-synthetic modification) that can, in some instances, improve the rejection and/or selectivity of the membrane. For example, the metal-organic framework may comprise functional groups bound to hydrophobic groups (e.g., alkyl chains) that assist with suspension stability in nonpolar solvents during membrane fabrication. As another example, the metal-organic framework may comprise functional groups bound to crosslinking agents that facilitate in situ crosslinking of the particles with the polymer matrix, thereby reducing voids in the membrane and/or leaching. In some instances, the membrane is a thin-film nanocomposite membrane (e.g., for separating components like charged species and/or neutral species) formed via, for example, interfacial polymerization in the presence of the particles.
B01D 67/00 - Procédés spécialement adaptés à la fabrication de membranes semi-perméables destinées aux procédés ou aux appareils de séparation
B01D 69/02 - Membranes semi-perméables destinées aux procédés ou aux appareils de séparation, caractérisées par leur forme, leur structure ou leurs propriétésProcédés spécialement adaptés à leur fabrication caractérisées par leurs propriétés
Peptide-E3 ubiquitin ligase fusions representing minimal protein to proteasome linkers are specifically targeted to degrade endogenous FOXP3 proteins in regulatory T cells. An engineered peptide for functional inactivation of a target regulatory T cell includes a fusion protein comprising a targeting domain and a ubiquitin ligase recruiting domain, wherein the targeting domain is engineered to bind FOXP3 of the target regulatory T cell for mediated degradation by the ubiquitin-proteosome pathway. The targeting domain may comprise a peptide having amino acid [SEQ ID No. 3], [SEQ ID No. 4], [SEQ ID No. 5], or [SEQ ID No. 6]. The ubiquitin ligase recruiting domain recruits an E3 ubiquitin ligase, which may be CHIPΔR [SEQ ID No. 2]. An engineered minimal, specific, nucleotide-encodable, FOXP3 protein to proteasome linker comprises a peptide-E3 ubiquitin ligase fusion in which the peptide binds to FOXP3. A method for treatment includes administering to a subject an engineered peptide-based therapeutic or pharmaceutically acceptable salt thereof, wherein the engineered peptide-based therapeutic comprises a peptide fusion of a targeting domain and a ubiquitin ligase recruiting domain, and wherein the targeting domain is engineered to bind FOXP3 of at least one regulatory T cell for mediated degradation by the ubiquitin-proteosome pathway.
Singapore-MIT Alliance for Research and Technology Centre (Singapour)
Nanyang Technological University (Singapour)
Massachusetts Institute of Technology (USA)
Inventeur(s)
Kwek, Kerwin Zeming
Tan, Kwan Zen Nicholas
Hou, Han Wei
Han, Jongyoon
Abrégé
Devices and methods for microfluidic parallel sample processing are described. According to an embodiment a microfluidic system for parallel sample processing is provided. The microfluidic system comprises one or more modules, each module comprising: one or more microfluidic chips arranged in a microfluidic chip stack, each of the one or more microfluidic chips comprising a plurality of processing channels, each processing channel comprising an inlet, an outlet, and a processing section, a combined sample inlet fluidically coupled to each processing channel inlet and configured to concatenate a plurality of the processing channel inlets, and a combined sample outlet fluidically coupled to each processing channel outlet and configured to concatenate a plurality of the processing channel outlets.
Described herein is the design and implementation of an instrumented user device to produce quantitative metrics of patient fall risk. In some embodiments, a regression algorithm is used to estimate postural sway velocity, which is an effective predictor of fall risk. The instrumented user device enables continuous patient monitoring outside of the clinic and could provide a long-term, quantitative measure of fall risk.
Provided herein are compositions, systems, and methods for delivering cargo to a target cell. The compositions, systems, and methods comprise one or more polynucleotides encoding one or more LTR retroelement polypeptides for forming a delivery vesicle and one or more capture moieties for packaging a cargo within the delivery vesicle. The one or more LTR retroelement polypeptides for forming a delivery vesicle may comprise two or more of an LTR retroelement gag protein, a retroelement envelope protein, an LTR retroelement reverse transcriptase, or a combination thereof. The LTR retroelement polypeptide alone, the LTR retroelement envelope protein alone, or both the LTR retroelement-derived polypeptide and LTR retroelement envelope protein may be endogenous. In some embodiments the LTR-retroelement-derived polypeptide is a PNMA polypeptide.
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
C12N 15/88 - Introduction de matériel génétique étranger utilisant des procédés non prévus ailleurs, p. ex. co-transformation utilisant la micro-encapsulation, p. ex. utilisant des vésicules liposomiques
7.
ELECTROCHEMICAL DIRECT AIR CAPTURE OF CARBON DIOXIDE USING REVERSIBLE REDOX-ACTIVE MATERIAL
An electrochemical direct air capture of carbon dioxide using a reversible redox-active material in an aqueous solution enabled by the inclusion of a hydrotropic agent. The electrochemical system demonstrates a high electron utility in continuous flow cell.
B01D 53/32 - Séparation de gaz ou de vapeursRécupération de vapeurs de solvants volatils dans les gazÉpuration chimique ou biologique des gaz résiduaires, p. ex. gaz d'échappement des moteurs à combustion, fumées, vapeurs, gaz de combustion ou aérosols par effets électriques autres que ceux prévus au groupe
Disclosed herein are capped RNA molecules comprising one or more modified nucleotides at position +3 or higher with reference to a 5' terminus of the RNA molecule, and methods of making the same. The capped RNA molecules may be made by ligating a 5'-capped modified RNA oligonucleotide to the 3' terminus of an RNA molecule. Also provided are compositions comprising one or more of the capped RNA molecules provided herein, and methods of using said compositions for therapeutic applications, such as in the treatment or prevention of a disease in a subject, such as SARS-CoV-2.
Quantum technology possesses broad applicability across emerging quantum sensing and quantum computing markets. Described herein is a passive device integrating a solid-state spin ensemble, electromagnetic transmission lines, electromagnetic interference shielding, and a heat spreader for robust quantum state control over a wide range of temperatures and electromagnetic frequencies. Quantum state control is carried out by integrating the solid-state spin ensemble into the non-resonant electromagnetic transmission line network and applying one or more time-varying electromagnetic signals to the input(s) of the device.
G01R 33/32 - Systèmes d'excitation ou de détection, p. ex. utilisant des signaux radiofréquence
G01R 33/12 - Mesure de propriétés magnétiques des articles ou échantillons de solides ou de fluides
G01R 33/26 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique pour la mesure de la direction ou de l'intensité de champs magnétiques ou de flux magnétiques utilisant le pompage optique
A device for converting light into an electron current emission is described. The device includes a substrate having first and second opposing surfaces. At least one antenna is disposed on the substrate. The at least one antenna is configured to absorb energy from photons having a selected wavelength. At least one dimension of the at least one antenna is a resonant length based on the selected wavelength. In response to photons incident thereon, at least a portion of the at least one antenna is heated to a degree which results in a thermionic emission from the antenna. The device also include at least one collector spaced apart from the at least one antenna by a selected distance. The at least one collector is configured to receive a Schottky emission from the at least one antenna. The received Schottky emissions may be used to signal a photon detection.
H04N 25/17 - Séparation des couleurs sur la base de la profondeur d'absorption des photons, c.-à-d. que la résolution des couleurs est obtenue simultanément à chaque emplacement de pixel
In one aspect, a method for rendering of a 3D aggregate image from crowd sourced image data is provided. The method includes receiving, at a server, from each of a plurality of user devices, user global multi-layer perceptron (MLP) weights generated from one or more images of a shared scene. The user global MLP weights are generated so as to not include personal content of a user. The method also includes aggregating the user global MLP weights using secure multi-party computation (SMPC) to further ensure exclusion of personal content. The method also includes sending, from the server to the plurality of user devices, updated weights, wherein the updated weights comprise aggregated global MLP weights. The user devices may then use the updated weights to further help in the implicit separation of personal and global content while retraining of their respective weights on local image data.
G06V 10/774 - Génération d'ensembles de motifs de formationTraitement des caractéristiques d’images ou de vidéos dans les espaces de caractéristiquesDispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant l’intégration et la réduction de données, p. ex. analyse en composantes principales [PCA] ou analyse en composantes indépendantes [ ICA] ou cartes auto-organisatrices [SOM]Séparation aveugle de source méthodes de Bootstrap, p. ex. "bagging” ou “boosting”
G06V 10/82 - Dispositions pour la reconnaissance ou la compréhension d’images ou de vidéos utilisant la reconnaissance de formes ou l’apprentissage automatique utilisant les réseaux neuronaux
G06V 20/30 - ScènesÉléments spécifiques à la scène dans les albums, les collections ou les contenus partagés, p. ex. des photos ou des vidéos issus des réseaux sociaux
12.
DIGITALLY PROGRAMMABLE ARBITRARY ANALOG FIR LTI FILTERS
Linear time-invariant (LTI) filters are a staple of modern signal processing. LTI filters perform many operations including signal estimation, bandpass/ stopband selection, encoding/decoding, modulation/demodulation, etc. Most modem LTI filters operate in the digital domain due to the flexibility of programming digital processors. However, this means that the incoming signal must be digitized. This introduces the signals to the bottlenecks and latency of digital computing, where digital electronics cannot process the increasing high data-rate and high-bandwidth data in dense spectral environments in real-time. The programmable analog LTI (PA-LTI) architecture is a hardware accelerator that performs real-time LTI operations in the analog domain and is fully programmable, enabling unprecedented acceleration of front-end PHY layer communications processing. Conventional analog LTI processors, such as RLC circuits or amplifiers, can perform only one LTI function. A PA-LTI processor can be digitally programmed to implement any arbitrary finite impulse response (FIR) LTI operation in the analog domain.
The present invention advantageously provides for use of a p-EMT signature for the treatment and prognosis of head and neck cancer across demographic groups. The p-EMT signature is differentially expressed across demographic groups. The p-EMT state indicates a high risk of metastasis and adverse clinical features that may be used to direct treatment of head and neck cancer.
C12Q 1/6886 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique pour le cancer
G01N 33/574 - Tests immunologiquesTests faisant intervenir la formation de liaisons biospécifiquesMatériaux à cet effet pour le cancer
15.
HIGH-TEMPERATURE CERAMIC COMBUSTOR WITH THERMOPHOTOVOLTAIC POWER GENERATION
A device for electricity generation can include a combustor/recuperator system comprising a recuperator, a combustor, and an emitter; wherein the recuperator comprises an intake for air and fuel, wherein the combustor burns fuels, transfers exhaust gases to the recuperator to preheat the air and fuel, and transfers heat of combustion to the emitter; and wherein the emitter radiates heat generated by the combustor; and a combustion thermophotovoltaic (c-TPV) array comprising a means of absorbing incident radiation from the emitter.
Compositions and methods for assessing relative macromolecule abundance (for example, RNA expression levels) in a spatially-defined manner across a tissue sample (for example, from brain, lung, liver, kidney, pancreas, and/or heart) are disclosed, specifically providing deep transcriptomic coverage at high-resolution (for example, at approximate 10 μm (single cell) resolution) across multiple locations assessed across the tissue sample
232222 gas onto ultramafic rocks; and 3) collection and separation of percolated fluid form water- ultramafic rocks to extract valuable trace elements therefrom. The integrated system can deliver reactants through a subsurface for reaction with rocks disposed below ground, and outlets for collecting the products from the earth.
C01B 3/02 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène
C01B 3/04 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par décomposition de composés inorganiques, p. ex. de l'ammoniac
C01B 3/06 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés inorganiques comportant un hydrogène lié électropositivement, p. ex. de l'eau, des acides, des bases, de l'ammoniac, avec des agents réducteurs inorganiques
18.
ELECTRICAL-DOUBLE-LAYER-FORCE-ENABLED TRANSFER OF VAN DER WAALS MATERIALS
In a method for transferring van der Waals materials, a van der Waals material is grown on or transferred onto a source substrate. A support layer is adhered to the van der Waals material. The source substrate with the van der Waals material is then immersed in a weak base solution, producing an electrical double layer at and between surfaces of (a) the van der Waals material and (b) the source substrate, wherein the electrical double layers generate a repulsive force that detaches the van der Waals material from the source substrate. The support layer with the adhered van der Waals material is separated from the source substrate. The support layer with the adhered van der Waals material is then applied to a target substrate. The support layer is then removed from the van der Waals material, leaving the van der Waals material adhered to the target substrate.
B32B 37/02 - Procédés ou dispositifs pour la stratification, p. ex. par polymérisation ou par liaison à l'aide d'ultrasons caractérisés par la séquence des opérations de stratification, p. ex. par addition de nouvelles couches à des postes successifs de stratification
B81C 1/00 - Fabrication ou traitement de dispositifs ou de systèmes dans ou sur un substrat
Systems, methods and compositions for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising IsrB polypeptides, novel IsrB nucleases and reprogrammable targeting nucleic acid components and methods and application of use are provided.
A computer-implemented method determines distribution of one or more amino acids in a cellular condensate. At least one perceptron layer to a protein language model. The at least one perceptron layer adapts the protein language model for predicting a probability of distribution of an amino acid sequence into a cellular condensate, thereby producing a modified protein language model. The modified protein language model is trained on a training dataset, which is a plurality of training amino acid sequences, each of which is annotated with one or more cellular condensates into which it partitions, thereby generating a trained protein language model. A test dataset of one or more test amino acid sequences can be applied to the trained protein language model to determine probability of partitioning of the one or more test amino acid sequences in the cellular condensate.
G16B 5/00 - TIC spécialement adaptées à la modélisation ou aux simulations dans la biologie des systèmes, p. ex. réseaux de régulation génétique, réseaux d’interaction entre protéines ou réseaux métaboliques
G16B 20/00 - TIC spécialement adaptées à la génomique ou protéomique fonctionnelle, p. ex. corrélations génotype-phénotype
G16B 30/00 - TIC spécialement adaptées à l’analyse de séquences impliquant des nucléotides ou des aminoacides
The present disclosure describes methods of treating a skin disorder in a subject in need thereof and methods of locally suppressing an immune response in a tissue of a subject in need thereof. The methods can include contacting a microneedle array comprising a plurality of microneedles with a skin surface of the subject, wherein the plurality of microneedles comprises: i) a degradable hyaluronic acid polymer comprising a disulfide bond, and ii) a therapeutic agent; and applying pressure on the microneedle array such that the plurality of microneedles penetrates the skin surface, thereby releasing the therapeutic agent beneath the skin surface while simultaneously capturing ISF for successive analysis.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
Described are systems and methods for projecting multiplane 3D images using a multiplane nanophotonic voxel engine. The multiplane nanophotonic voxel engine may include a laser light source and a photonic integrated circuit. The photonic integrated circuit may include a plurality of beam-steering cantilevers and a plurality of modulators. The plurality of beam-steering cantilevers may be piezoelectrically actuated beam-steering cantilevers. Each piezoelectrically actuated beam-steering cantilever may comprise a plurality of embedded waveguides that can emit light in various directions based on the actuation of the cantilever in order to generate a portion of an image.
This invention relates to systems and methods for adaptive discovery and mixed-variable optimization of synthesizable microelectronic materials, and applications of the same. Specifically, an exemplary system includes a virtual screening (VS) module to extract information from literatures of a knowledge base by text mining, a ML-assisted conceptual exploration (CE) module to identify candidate material families for the specific class of compound materials based on the extracted information via a combination of ML models and to generate exogenous models of objective functions f(x, y) and constraint functions g(x, y), and an adaptive discovery (AD) engine to generate and optimize design of the newly discovered compound materials. The AD engine includes a mixed-variable ML module, a mixed-integer optimization (MIO) module, and a high-fidelity evaluation (HFE) module, which are iteratively and sequentially executed.
G16C 20/70 - Apprentissage automatique, exploration de données ou chimiométrie
24.
COMPOSITIONS AND METHODS THAT PROMOTE HYPOXIA OR THE HYPOXIA RESPONSE FOR TREATMENT AND PREVENTION OF MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE STRESS DISORDERS
A system includes an enclosed tent or chamber or a breathing apparatus, a hypoxia induction system and a device for measuring arterial oxygen saturation in a subject breathing air within the enclosed tent or chamber or from the breathing apparatus. The hypoxia induction system delivers oxygen-depleted air having between 5 to 20% O2 to the enclosed tent or chamber or breathing apparatus. The system adjusts the oxygen content of the oxygen-depleted air being delivered to the enclosed tent or chamber or the breathing apparatus based upon the arterial oxygen saturation measured by the device such that oxygen saturation in the subject is maintained within a range of 50% to 90%.
A61K 31/472 - Isoquinoléines non condensées, p. ex. papavérine
A61K 31/4745 - QuinoléinesIsoquinoléines condensées en ortho ou en péri avec des systèmes hétérocycliques condensées avec des systèmes cycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. phénanthrolines
A61K 31/5377 - 1,4-Oxazines, p. ex. morpholine non condensées et contenant d'autres hétérocycles, p. ex. timolol
A61M 16/06 - Masques respiratoires ou pour l'anesthésie
A61M 16/10 - Préparation de gaz ou vapeurs à respirer
A61M 16/12 - Préparation de gaz ou vapeurs à respirer par mélange de gaz différents
A61P 25/14 - Médicaments pour le traitement des troubles du système nerveux pour traiter les mouvements anormaux, p. ex. chorée, dyskinésie
C07K 14/00 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés
C12N 15/11 - Fragments d'ADN ou d'ARNLeurs formes modifiées
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
25.
METHODS OF DELIVERING THERAPEUTIC AGENTS, AND LIPID COMPOSITIONS
The object of the present invention is to provide a method for delivering a therapeutic agent to endothelial cells, mesenchymal cells, or cancer cells which can realize excellent delivery efficiency to organs other than the liver, and a composition containing a therapeutic agent and lipid nanoparticles which can realize excellent delivery efficiency to an organ other than the liver. The present invention provides a method for delivering a therapeutic agent to endothelial cells, mesenchymal cells, or cancer cells, which comprises administering a lipid composition to a subject, wherein the lipid composition comprises the therapeutic agent and lipid nanoparticle,
and wherein the lipid nanoparticle comprises an ionizable lipid and a compound represented by formula (1) or a salt thereof.
The object of the present invention is to provide a method for delivering a therapeutic agent to endothelial cells, mesenchymal cells, or cancer cells which can realize excellent delivery efficiency to organs other than the liver, and a composition containing a therapeutic agent and lipid nanoparticles which can realize excellent delivery efficiency to an organ other than the liver. The present invention provides a method for delivering a therapeutic agent to endothelial cells, mesenchymal cells, or cancer cells, which comprises administering a lipid composition to a subject, wherein the lipid composition comprises the therapeutic agent and lipid nanoparticle,
and wherein the lipid nanoparticle comprises an ionizable lipid and a compound represented by formula (1) or a salt thereof.
wherein G1 represents —C(O)—, —OC(O)—, —O(CO)O— or —C(O)O—,
LY represents a single bond, an alkylene group having 1-14 carbon atoms, a substituted alkylene group having 1-14 carbon atoms, a heteroalkylene group having 1-14 carbon atoms, and a substituted heteroalkylene group having 1-14 carbon atoms.
X represents a basic functional group.
A method, carried out by one or more processing devices, is used for mapping cells on Earth that contain communications terminals to communications spacecraft or aircraft, as appropriate, referred to as satellite routing. The method comprises: grouping the cells into groups or clusters by applying clustering techniques; mapping the groups of cells to spacecraft or aircraft; and outputting parameters usable to control at least one spacecraft or aircraft to provide service to the assigned cells. The invention also relates to a system, computer program products, and a method and system for simulating a satellite routing.
27.
SYSTEMS AND METHODS FOR GEOLOGIC HYDROGEN PRODUCTION
C01B 3/06 - Production d'hydrogène ou de mélanges gazeux contenant de l'hydrogène par réaction de composés inorganiques comportant un hydrogène lié électropositivement, p. ex. de l'eau, des acides, des bases, de l'ammoniac, avec des agents réducteurs inorganiques
E21B 43/16 - Procédés de récupération assistée pour l'extraction d'hydrocarbures
E21B 43/26 - Procédés pour activer la production par formation de crevasses ou de fractures
28.
MECHANOCHEMICAL REDUCTION OF PHOSPHATES AS A SUSTAINABLE ROUTE TO PHOSPHITE SALTS AND ORGANOPHOSPHITE COMPOUNDS
Disclosed herein, among other things, are methods for the mechanochemical synthesis of phosphite salts and organophosphite compounds from phosphates, such as condensed phosphates.
22). Some aspects are related to electrocatalysts comprising copper nanoparticles having shapes and/or compositions that may desirably affect their electrocatalytic performance, for instance, the related faradaic efficiencies and/or product distributions obtained during electrocatalysis using the nanoparticles. Still other aspects are generally directed to related methods of making and/or using the electrocatalysts and/or systems.
H01M 4/12 - Procédés de fabrication d'électrodes en métal ou en alliage consommables
B82Y 15/00 - Nanotechnologie pour l’interaction, la détection ou l'actionnement, p. ex. points quantiques comme marqueurs en dosages protéiques ou moteurs moléculaires
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
B01J 19/00 - Procédés chimiques, physiques ou physico-chimiques en généralAppareils appropriés
B01L 3/00 - Récipients ou ustensiles pour laboratoires, p. ex. verrerie de laboratoireCompte-gouttes
A robotic system has a hand with multiple finger whose state is controllable by a controller, an imaging device for providing depth images of the hand and objects held by the hand, and the controller. The controller implements a policy computation for processing data determined from depth images of an object held by the hand to provide commands for the hand to reorient the object held in the hand while maintaining support of the object during the reorientation. A training system determines values of configurable parameters of the policy computation module by processing data representing simulated manipulation of a plurality of shapes of objects by the hand, for example, using a reinforcement learning procedure.
31.
Magnetic Resonance Relaxometry (MRR) Measurement to Predict Chondrogenic Potential of Mesenchymal Stem Cells (MSCS)
Chondrogenic potential of mesenchymal stem cells (MSCs) can be determined using magnetic resonance relaxometry by measuring T2 relaxation value of the MSCs.
G01R 33/44 - Dispositions ou appareils pour la mesure des grandeurs magnétiques faisant intervenir la résonance magnétique utilisant la résonance magnétique nucléaire [RMN]
C12N 5/077 - Cellules mésenchymateuses, p. ex. cellules osseuses, cellules de cartilage, cellules stromales médulaires, cellules adipeuses ou cellules musculaires
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
G01R 33/30 - Dispositions pour le traitement des échantillons, p. ex. cellules d'essai, mécanismes rotationnels
G01R 33/465 - Spectroscopie RMN appliquée à du matériau biologique, p. ex. tests in vitro
32.
APPARATUS FOR HIGH THROUGHPUT ASSESSMENT OF CELL PROPERTIES, FRAGILITY OR DEFORMABILITY
The disclosure provides apparatus and methods related to the assessment of the fragility and/or deformability of cells, comprising applying negative pressure to an interior volume defined by a hollow member that comprises a fenestration, wherein the negative pressure is sufficient to(1 ) partially aspirate a cell into the interior volume of the hollow member through the fenestration at a time to, and (2) following to, rupture the cell at a time tr, resulting in the complete aspiration of the cell into the interior volume of the hollow member, and measuring a time to rupture of the cell (T) between tr and to. The apparatus and methods provided herein use small sample volumes and provide improved sensitivity and reproducibility over existing methods of assessing cell fragility and/or deformability. The apparatus and methods provided herein are useful for, e.g., evaluating the quality of stored blood to facilitate decisions regarding transfusion and diagnosing a disease, disorder, or condition.
G01N 15/10 - Recherche de particules individuelles
G01N 33/50 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique
33.
PROGRAMMABLE MICROFLUIDIC DEVICES AND METHODS OF MAKING AND USING THEREOF
Fluidic devices and programmable fluidic systems, which mimic fluid flow mechanisms found in biological systems are described herein. Methods of using and making such devices and systems are also disclosed.
B01F 27/21 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins caractérisés par leurs arbres de rotation
B01F 27/23 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins caractérisés par l'orientation ou la disposition de l'axe du rotor
B01F 27/85 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins avec des agitateurs tournant autour d'un axe sensiblement vertical avec plusieurs agitateurs sur des arbres séparés
B01F 27/806 - Mélangeurs à agitateurs tournant dans des récipients fixesPétrins avec des agitateurs tournant autour d'un axe sensiblement vertical les agitateurs ou les récipients étant déplacés afin de les mettre en position de fonctionnementMoyens de fixation du récipient avec déplacement vertical de l'agitateur, p. ex. en combinaison avec des moyens permettant de faire pivoter l'agitateur autour d'un axe vertical afin de coopérer avec différents récipients
B01F 27/2124 - Arbres à longueur réglable, p. ex. arbres télescopiques
34.
VACCINE TARGETING TO MUCOSAL LYMPHOID TISSUES IN THE GASTROINTESTINAL TRACT
Viruses, bacteria, and parasites frequently cause infections in the gastrointestinal (GI) tract, but traditional vaccination strategies typically elicit little or no mucosal antibody responses. Disclosed herein is a vaccine comprising a nanoemulsion and an immunogen non-covalently conjugated to the surface of the nanoemulsion by an amphiphilic linker, wherein the vaccine is suitable for inducing a mucosal antibody response in the gastrointestinal tract. Also disclosed are methods of using the vaccine to immunize a subject by intraperitoneal administration of an effective amount of the vaccine, alone or with an adjuvant.
A61K 39/39 - Préparations médicinales contenant des antigènes ou des anticorps caractérisées par les additifs immunostimulants, p. ex. par les adjuvants chimiques
A61K 47/54 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique
A61K 47/69 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament le conjugué étant caractérisé par sa forme physique ou sa forme galénique, p. ex. émulsion, particule, complexe d’inclusion, stent ou kit
C08G 69/10 - Polyamides dérivés, soit des acides amino-carboxyliques, soit de polyamines et d'acides polycarboxyliques dérivés d'acides aminocarboxyliques d'acides alpha-aminocarboxyliques
CENTER FOR DRUG DISCOVERY, RTI INTERNATIONAL (USA)
PRESIDENT AND FELLOWS OF HARVARD COLLEGE (USA)
Inventeur(s)
Collins, James Joseph
Krishnan, Aarti
Valeri, Jacqueline Alexus
Wong, Felix J.
Jin, Wengong
Anahtar, Melis Nuray
Luttens, Andreas
Blough, Bruce
Jin, Chunyang
Abrégé
Pharmaceutical compositions are disclosed. The pharmaceutical compositions include an antimicrobial compound. The compositions can also include a pharmaceutically acceptable carrier. Discovery methods for discovery of antimicrobial compounds are also disclosed. The discovery methods employ a trained machine learning model to identify substructures of chemical compounds that are predicted to exhibit antimicrobial activity. Antimicrobial activity of known compounds can be discovered and antimicrobial compounds with identified substructures can be generated and/or synthesized.
Some aspects are generally related to electrocatalysts, for example, for use during electrocatalysis. In some embodiments, the electrocatalysts may be included in a system configured to perform electrocatalysis. For instance, a system may include an electrode that is associated with a first oligo- or polynucleotide and an electrocatalyst that is associated with a second oligo- or polynucleotide. According to some such embodiments, the first and second oligo- or polynucleotides may at least partially base pair and substantially tether the electrocatalyst to the electrode. In some cases, the electrocatalyst comprises nanoparticles comprising copper (Cu), which may be suitable to be configured in a system for the electrocatalytic reduction of carbon dioxide (CO2). Some aspects are related to electrocatalysts comprising copper nanoparticles having shapes and/or compositions that may desirably affect their electrocatalytic performance, for instance, the related faradaic efficiencies and/or product distributions obtained during electrocatalysis using the nanoparticles. Still other aspects are generally directed to related methods of making and/or using the electrocatalysts and/or systems.
Systems, methods and composition for targeting polynucleotides are detailed herein. In particular, engineered DNA-targeting systems comprising novel Fanzor polypeptides and a reprogrammable targeting nucleic acid component and methods and application of use are provided.
A mixed ionic and electronic conductors (MIEC) material for a battery includes a combination of niobium (Nb), tungsten (W), titanium (Ti), and/or oxygen (O) forming a super-MIEC material with an increased alkali ion metal diffusivity. In one example, the MIEC material is a Nb—W—Ti-0 material with an anion-to-cation ratio ranging from about 2.33 to about 2.8 where the anion is O and the cation is Nb, W, and Ti. The MIEC material may be a coarse-grained material that includes particles consisting essentially of Nb, W, Ti, and/or O and having a dimension of at least 0.1 μm. The MIEC material may have an open pore structure with pores having a pore diameter from about 2.5 Å to about 2.8 Å. The MIEC material may also include carbon (C) that coats each particle. The MIEC material may be incorporated into an anode or a cathode of a lithium-ion battery.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
Existing clinically adopted epicardial pacing leads mostly rely on surgical suturing or insertion of electrodes to the heart tissue. However, these approaches can cause tissue trauma during application and/or retrieval of the implants, potentially causing detrimental complications such as bleeding, tissue damage, and/or device failure. The present invention provides a bioadhesive epicardial pacing lead for atraumatic epicardial monitoring and stimulation of the heart in vivo to overcome the limitations of existing bioelectronic implants. The bioadhesive pacing lead is composed of an insulation layer, a conductive bioadhesive interface, a built-in reservoir, an electrode lead wire, and a fluidic channel. The bioadhesive pacing lead shows robust mechanical and electrical properties, biocompatibility, continuous epicardial monitoring and pacing capability, and rapid on-demand atraumatic employment and removal.
A61N 1/05 - Électrodes à implanter ou à introduire dans le corps, p. ex. électrode cardiaque
A61L 24/04 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires
A61L 24/06 - Adhésifs ou ciments chirurgicauxAdhésifs pour dispositifs de colostomie contenant des matériaux macromoléculaires obtenus par des réactions faisant intervenir uniquement des liaisons carbone-carbone non saturées
Architected artificial reefs including modules of optimally arranged and sized multiple porous cylindrical bodies achieve an unprecedented wave energy dissipation rate, quantified through an equivalent drag coefficient of the order of 20, providing coastal protection against storms using a fraction of the material required in conventional artificial reefs. Selected porosity and selected material for the bodies within each reef module preserves the capacity for high drag coefficient, while offering the added advantages of ensuring a shelter to marine life, as well as making the building of the reefs in the field modular and efficient. Optimization of the dimensions and location of the multiple cylinders allow targeted design to fit the specific wave characteristics and bottom topography of the location to be protected. Architected artificial reefs with multiple porous and non-porous cylinders with overall diameters comparable to the wave height lead to high drag coefficients.
Methods of preparing trans-silacycloheptenes and their use in preparing polymers thereof under ring-opening metathesis polymerization (ROMP) conditions are disclosed. Also disclosed are methods for preparing oligosilane diene monomers and their use in preparing unsaturated poly(carbooligosilane)s via acyclic diene metathesis polycondensation. The alkene moieties of the unsaturated poly(carbooligosilane)s can be converted to epoxides via post-polymerization epoxidation.
C08G 77/60 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant du silicium, avec ou sans soufre, azote, oxygène ou carbone dans lesquels tous les atomes de silicium sont liés autrement que par des atomes d'oxygène
C07F 7/08 - Composés comportant une ou plusieurs liaisons C—Si
C08G 77/00 - Composés macromoléculaires obtenus par des réactions créant dans la chaîne principale de la macromolécule une liaison contenant du silicium, avec ou sans soufre, azote, oxygène ou carbone
42.
SCALABLE AND HIGH THROUGHPUT ASSEMBLY OF LAYER-BY-LAYER NANOPARTICLES
Surface modification of nanoparticles (NPs) via the layer-by-layer (LbL) technique is a approach to generate targeted drug delivery vehicles. A simple and scalable synthesis method for LbL-NPs that can be adapted for clinical translation is of great interest. Presented herein is a robust and scalable method of polymer deposition onto nanoparticles.
A61K 47/64 - Conjugués médicament-peptide, médicament-protéine ou médicament-acide polyaminé, c.-à-d. l’agent de modification étant un peptide, une protéine ou un acide polyaminé lié par covalence ou complexé à un agent thérapeutiquement actif
B82Y 30/00 - Nanotechnologie pour matériaux ou science des surfaces, p. ex. nanocomposites
Compositions, articles, and methods related to batteries (e.g., sodium-ion batteries) including carbon nanostructure (e.g., carbon nanotube) composites are generally described. In certain embodiments, a composite comprises: (i) an electrochemically active material comprising a bis-tetraamino-benzoquinone molecule and/or a dimer, tautomer, oligomer, polymer, and/or derivative thereof; and (ii) at least one carbon nanotube (CNT). In some embodiments, the composite may be suitable for use as an electrode and/or an electrode material in an electrochemical cell. In certain embodiments, the electrochemical cell is a battery (e.g., a rechargeable battery, such as a sodium-ion battery).
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.
Systems and methods are disclosed for high torque density mechanical couplings with variable slip control. The disclosed couplings can achieve order-of-magnitude (∼10x) improvements in torque density over existing magnetic and fluid options by leveraging combined normal, frictional, and inertial forces acting on sliding mechanical elements to transmit torque. The disclosed couplings can allow for continuous modulation of high-torque loads while naturally achieving lockup at maximum engagement and remaining well-suited to forced-convection cooling in high-heat-dissipation scenarios. Additionally, the disclosed couplings can be configured to achieve "one-way clutching" behavior while retaining the ability to speed-synchronize (transmit load under partial slip) and achieve lockup. These characteristics make the disclosed couplings well suited to a variety of applications and fields, including automotive and mobile robotics applications, such as active control of vehicle differential slip, where high torque density and slip control are both of critical importance.
F16D 3/50 - Accouplements extensibles, c.-à-d. avec moyens permettant le mouvement entre parties accouplées durant leur entraînement avec pièces d'accouplement reliées par un ou plusieurs organes intermédiaires
F16H 13/06 - Transmissions pour transmettre un mouvement rotatif à rapport de vitesse constant par friction entre des organes rotatifs avec organes à mouvement orbital
F16D 3/00 - Accouplements extensibles, c.-à-d. avec moyens permettant le mouvement entre parties accouplées durant leur entraînement
This disclosure provides a device for assessing forces in tissues and methods of use thereof. The device may be used, for instance, to probe forces associated with characteristics to regulate spatial displacement of a tissue in one or more directions. The device may have at least two rigid attachment points for supporting a tissue and connected to a compliant mechanism to allow displacement of a tissue in a direction x, wherein tissue displacement is constrained in at least one direction other than x. The device may have a compliant mechanism with a stiffness value in a displacement direction that is lower than a stiffness value of the tissue in the displacement direction and/or at least one of the rigid attachment points having a stiffness value in the displacement direction that is higher than a stiffness value of the tissue in the displacement direction.
Electrochemical cells (e.g., batteries) that operate across extreme temperatures (e.g., greater than or equal to 50 °C and/or less than or equal to 0 °C), and related methods, are generally described.
H01M 10/0525 - Batteries du type "rocking chair" ou "fauteuil à bascule", p. ex. batteries à insertion ou intercalation de lithium dans les deux électrodesBatteries à l'ion lithium
Extremely Large Area Integrated Circuits (ELAIC) may become an attractive tiling method for 2D integration to meet the demands of higher functionality in ever smaller packages, especially when coupled with the use of heterogeneous chips. This new tiling solution is suitable for combining multiple memory, ASICs, CPU, GPU, etc., into a single package. This approach also favors system integration with high density power delivery by appropriate build-up materials, design and thermal management. ELAIC technology with bare multi-die integration offers a number of advantages relative to the equivalent integration methods.
H01L 25/16 - Ensembles consistant en une pluralité de dispositifs à semi-conducteurs ou d'autres dispositifs à l'état solide les dispositifs étant de types couverts par plusieurs des sous-classes , , , , ou , p. ex. circuit hybrides
49.
GENERATION OF OXYGEN FROM ACTIVATED ALUMINUM AND INORGANIC ACIDS
Oxygen generators and methods related to the generation of oxygen using activated aluminum alloys and inorganic acids such as nitric acid are generally described. In some embodiments, aluminum nitrate is thermally decomposed to produce oxygen and nitrogen dioxide. The nitrogen dioxide may also optionally be used to produce oxygen gas. In some embodiments, a reaction between nitric acid and an activated aluminum alloy may be used to produce the aluminum nitrate. In other embodiments, a reaction between nitric acid and aluminum hydroxide may be used to produce the aluminum nitrate.
An electrochemical sensor extracts information from biofluid systems by harnessing a nonlinear dynamic electrochemical model and stochastic voltage or current input. It uses a black-box approach that describes the fluid's state and predicts its evolution over time using a collection of model parameters, nonlinear dynamic measurement modes, and modeling techniques. For example, the sensor can use principal component analysis to reduce the set of (potentially hundreds) of model parameters to a handful of latent variables which evolve independently of each other. The sensor can use a set of these latent variables as a description of the state of the fluid. For a given sample fluid (e.g., milk containing contaminants), the sensor collects trajectories of the fluid state over time under varying conditions, permitting the training of a machine learning model to predict either fluid state trajectories or time until the fluid state crosses a given threshold (e.g., spoilage).
G01N 27/27 - Association de plusieurs systèmes ou cellules de mesure, chacun mesurant un paramètre différent, dans laquelle les résultats des mesures peuvent être, soit utilisès indépendamment, les systèmes ou les cellules étant physiquement associés, soit combinés pour produire une valeur représentative d'un autre paramètre
51.
ONE-STEP CONSTRUCTION OF ALLOGENIC CAR-NK CELLS WITH INCREASED ANTI-TUMOR CYTOTOXICITY AND RESISTANCE TO HOST CELL REJECTION
The present disclosure relates to RNAi DNA oligonucleotides for the suppression of an immune response and use in methods of one step construction of allogenic CAR cells capable of avoiding a host rejection.
The techniques described herein relate to secure large language models. An example method includes training at least one pre-trained model using training data to generate a set of parameters for configuring portion(s) of the at least one pre-trained model to generate an output associated with the training data, generating data association(s) of one or more users and the set of parameters, performing the above among different sets of training data to generate a plurality of sets of parameters, each of which corresponding to a different one of the different sets of training data, and for at least one user of the user(s), identifying, by using the data association(s), one or more of the sets of parameters that correspond to the at least one user, and generating a trained model for the at least one user based on a combination of the at least one pre-trained model and the identified parameters.
53.
METHODS OF MODULAR CONSTRUCTION OF 0D-STATE TUNNEL JUNCTION DEVICES AND METHODS OF USE THEREOF
A method of synthetizing a photonic crystal is disclosed. The method uses nanoparticles to seed the creation of siloxane-based nanoparticles, having a diameter as small as 20 nm. The seed nanoparticles may be gold nanoparticles and the silane may be 3-(trimethoxysilyl)propyl methacrylate (TPM). These siloxane-based nanoparticles are separated from a basic solution and are used to create the photonic crystal. This may be achieved using drop casting, centrifugation or another method. The siloxane-based nanoparticles are then assembled into a photonic crystal. The photonic crystal may reflect light in the visible spectrum in an angle independent manner.
B82Y 20/00 - Nano-optique, p. ex. optique quantique ou cristaux photoniques
G02B 1/02 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques faits de cristaux, p. ex. sel gemme, semi-conducteurs
G02B 1/00 - Éléments optiques caractérisés par la substance dont ils sont faitsRevêtements optiques pour éléments optiques
55.
SYSTEMS, DEVICES, AND METHODS FOR HIGH-RECOVERY ELECTRODIALYSIS FOR HOUSEHOLD DESALINATION
The present disclosure is directed to systems, devices, and methods for electrodialysis-based home-scale water desalination. The system can include an electrodialysis (ED) stack that includes a separately disposed electrode rinse stream that is in a closed-loop configuration with the ED stack. The electrode rinse stream can flow from a separate rinse storage vessel and can, optionally, include an auxiliary pump dedicated to pumping the electrode rinse to the ED stack. The ED stack can include one or more compression molded spacers disposed between the electrodes and membranes thereof and endcapend caps on the periphery of the ED stack to reduce a volume of the system to allow for point of use operation. The system and its components can be packaged within dimensions of a reverse osmosis cabinet, which can provide for in-home installation and use.
C02F 1/469 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par séparation électrochimique, p. ex. par électro-osmose, électrodialyse, électrophorèse
C02F 1/461 - Traitement de l'eau, des eaux résiduaires ou des eaux d'égout par des procédés électrochimiques par électrolyse
56.
ONE-STEP CONSTRUCTION OF ALLOGENIC CAR-NK CELLS WITH INCREASED ANTI-TUMOR CYTOTOXICITY AND RESISTANCE TO HOST CELL REJECTION
The present disclosure relates to RNAi DNA oligonucleotides for the suppression of an immune response and use in methods of one step construction of allogenic CAR cells capable of avoiding a host rejection.
A61K 40/11 - Lymphocytes T, p. ex. lymphocytes infiltrant les tumeurs [TIL] ou lymphocytes T régulateurs [Treg]Cellules tueuses activées par les lymphokines [LAK]
Disclosed herein is a sensor, comprising a cable structure having a plurality of cords stitched together in a crown sinnet configuration and at least one conductive element integrated into the cable structure to form a plurality of loops. At least two different loops of the plurality can contact each other in response to a geometric change in the cable structure, thereby changing a resistance of the conductive element. In some embodiments, the geometric change is caused by at least one of a: tension of the cable structure; compression of the cable structure; or bending of the cable structure.
G01B 7/16 - Dispositions pour la mesure caractérisées par l'utilisation de techniques électriques ou magnétiques pour mesurer les déformations dans un solide, p. ex. au moyen d'une jauge de contrainte à résistance
B32B 5/12 - Produits stratifiés caractérisés par l'hétérogénéité ou la structure physique d'une des couches caractérisés par les caractéristiques de structure d'une couche comprenant des fibres ou des filaments caractérisés par la disposition relative des fibres ou filaments des couches adjacentes
D02G 3/40 - Filés dans lesquels les fibres sont réunies par des adhésifsFilés ou fils imprégnés
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Scientific research; Scientific research and development; Scientific research consulting; Providing scientific research information; Providing scientific research information in the field of pharmaceuticals; Biotechnology research; Research and development in the pharmaceutical and biotechnology fields; Biotechnology research in the field of food and agriculture; Chemical research; Biochemical research and development; Research in the field of food and beverages; Food research; Product research and development; Research and development of new products; Scientific research in the field of dietary supplements and nutritional supplements; Research and development in the field of dietary supplements and nutritional supplements; Research and development of new products in the field of pharmaceuticals; Agricultural research; Research in the field of engineering; Research in the field of beverages; Research in the field of food; Research in the field of bioengineering; Product development; Product development and engineering services for others; Consulting services in the field of product design and development; Research and development in the field of biotechnology; Pharmaceutical research and development; Research and development services in the field of engineering; Research and development of technology in the field of cancer detection, diagnosis, treatment, and prevention; Research and development and consultation related thereto in the field of oncology; Research and development in the field of brain and cognitive sciences; Research and development in the field of neurology; Research and development of technology in the field of food science and human health; Research and development in the field of biological engineering; Research and development in the field of earth, atmospheric, climate, and planetary sciences; Research and development in the field of energy; Research and development in the field of ocean engineering; Research and development in the field of aerospace; Research and development in the field of architecture; Research and development in the field of urban planning; Research and development in the field of nanoscience and nanotechnology; Research and development in the field of soldier nanotechnologies; Research and development in the field of emerging technologies; Research and development in the field of education; Research and development in the field of robotics; Computer system design; Design and development of computer hardware and software; Scientific and technological services, namely, research and design in the field of computer science; Scientific research in the field of biology; Scientific research in the field of plants and plant biology; Biotechnology research in the field of plants; Biotechnology research in the field of life sciences; Research and development in the field of computer technology; Scientific laboratory services; Computer software design; Computer software development; Computer hardware design; Computer hardware development
59.
GENERATIVE OPTIMIZATION MODELS FOR MACHINE LEARNING
A sample batch is accessed and a conditioning is computed based on given constraints. A dense relaxation is computed based on the computed conditioning and the sample batch to generate kernels for conditioning a diffusion optimization model. A sample is selected from the sample batch based on a randomly sampled timestep and random noise is sampled from a Gaussian distribution. A noisy representation of the selected sample is sampled based on the randomly sampled timestep and the sampled random noise. The diffusion optimization model is run in a forward direction using the noisy representation of the selected sample to generate a prediction. An error loss is computed to minimize an error between the prediction and a target; the target is the sampled random noise. A diffusion optimization loss is computed based on the error loss and the diffusion optimization model is updated based on the diffusion optimization loss using backpropagation.
Provided herein are compositions comprising Escherichia coli (E. coli), Saccharomyces boulardii (S. boulardii), Lactobacillus plantarum (L. plantarum), and/or Ensifer meliloti (E. meliloti) and a first stabilizing excipient. Also provided herein are methods of delivering E. coli, S. boulardii, L. plantarum, and/or E. meliloti to a subject in need thereof, methods of inducing bacterial growth in a subject or in a cell, tissue, or biological sample, and methods of inhibiting an enteric pathogen in a subject or in a cell, tissue, or biological sample. Further provided herein are methods of treating dysbiosis in a subject in need thereof.
Radio Frequency Identification (RFID) tags having functionalized carbon nanotubes (CNTs) engineered to change in resistance when exposed to a variety of analytes to provide an inexpensive framework for distributed sensing. For example, a printing process can be developed for liquid inks comprising CNTs, and RFID sensors can be fabricated with functionalized CNTs as the active elements. The tags can work independent of distance and can sense changes in resistance of a sensing element. The tags can include an antenna with an inductive loop and two sets of dipole arms having functionalized carbon nanotubes, and a RFID chip that separates the two sets of dipole arms. The dipole arms can capture an analyte on a plurality of sensors and generate a plurality of resonant peaks therefrom. The peaks can be analyzed by comparing the damping therebetween, or by shifting the resonant frequency of the tag to determine presence of the analyte.
G06K 19/07 - Supports d'enregistrement avec des marques conductrices, des circuits imprimés ou des éléments de circuit à semi-conducteurs, p. ex. cartes d'identité ou cartes de crédit avec des puces à circuit intégré
G06K 19/077 - Détails de structure, p. ex. montage de circuits dans le support
62.
METHODS AND DEVICES FOR PROVIDING A STIMULUS TO A SUBJECT TO INDUCE GAMMA OSCILLATIONS
A method includes administering a non-invasive stimulus to a subject having a frequency of about 35 Hz to about 45 Hz to induce synchronized gamma oscillations in at least one brain region of the subject.
A61M 21/00 - Autres dispositifs ou méthodes pour amener un changement dans l'état de conscienceDispositifs pour provoquer ou arrêter le sommeil par des moyens mécaniques, optiques ou acoustiques, p. ex. pour mettre en état d'hypnose
A61H 23/00 - Massage par percussion ou vibration, p. ex. en utilisant une vibration ultrasoniqueMassage par succion-vibrationMassage avec des membranes mobiles
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
63.
GENERATING BRONSTED ACID CATALYSTS BY ELECTRICAL POLARIZATION
Disclosed are methods of modulating the surface acidity of a catalyst and methods of catalyzing chemical reactions with a modified catalyst. Also disclosed are methods and reactors for catalyzing chemical reactions with catalysts having modulated surface acidity.
Embodiments of the present disclosure are directed towards a heterogenous catalyst composition formed from using a crystalline porous metal-organic framework (MOF) that reacts in an inverse electron-demand Diels-Alder reaction with a phosphorous ligand to produce a heterogeneous catalyst precursor. The heterogeneous catalyst precursor can react with a Group VIII transition metal catalyst precursor compound to form the heterogeneous catalyst composition that can be used for the hydroformylation of olefins, among other reactions.
C07C 45/50 - Préparation de composés comportant des groupes C=O liés uniquement à des atomes de carbone ou d'hydrogènePréparation des chélates de ces composés par réaction avec le monoxyde de carbone par synthèse oxo
C07C 47/02 - Composés saturés comportant des groupes —CHO liés à des atomes de carbone acycliques ou à de l'hydrogène
B01J 31/18 - Catalyseurs contenant des hydrures, des complexes de coordination ou des composés organiques contenant des complexes de coordination contenant de l'azote, du phosphore, de l'arsenic ou de l'antimoine
65.
COMPOSITIONS, SYSTEMS, KITS, AND METHODS FOR TREATING WOUNDS
Disclosed are compositions, kits, systems, and methods for treating or healing a wound. The compositions can include a carrier composition with a gas-entrapping material and a gas entrapped within the carrier composition.
A61K 33/00 - Préparations médicinales contenant des ingrédients actifs inorganiques
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61P 17/02 - Médicaments pour le traitement des troubles dermatologiques pour traiter les blessures, les ulcères, les brûlures, les cicatrices, les cheloïdes, ou similaires
This disclosure provides novel integrases for site-specific genetic engineering. Also provided are systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE) with the novel integrases.
Provided herein are zwitterionic polymer (ZIP)-lipids and pharmaceutically-acceptable salts thereof; lipid nanoparticles (LNPs) comprising such ZIP-lipids; formulations comprising ZIP-lipid containing LNPs; methods of delivering ZIP-lipid containing LNPs, or formulations thereof, to a subject; and methods of treating a disease, dirsorder or condition comprising administering ZIP-lipid containing LNPs, or formulations thereof, to a subject.
A61P 11/00 - Médicaments pour le traitement des troubles du système respiratoire
C08F 265/10 - Composés macromoléculaires obtenus par polymérisation de monomères sur des polymères d'acides monocarboxyliques non saturés ou de leurs dérivés tels que définis dans le groupe sur des polymères d'amides ou d'imides
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
36 - Services financiers, assurances et affaires immobilières
41 - Éducation, divertissements, activités sportives et culturelles
Produits et services
Business research; Business research in the field of economics; Business consultation; Publicity campaigns regarding the alleviation of poverty; Promoting public awareness and public advocacy in the field of poverty; Business research in the field of economics, to reduce poverty by generating and promoting the use of rigorous scientific evidence based on randomized control trials (RCTs) to inform social and economic policy; Business research in the field of economics that is globally informed and locally grounded, through collaborations between researchers, implementers, and funders, policy outreach and events, capacity building training courses, publications and communications, and other related activities; Business evaluations; Economic forecasting services; Economic feasibility studies; Economic forecasting analysis for business purposes; Promoting economic growth in developing countries; Providing information in the field of economics; Providing information and analysis in the fields of economics and business; Public policy consultation; Promoting public awareness of public policy issues and initiatives; Promoting public awareness in the field of social welfare; Arranging and conducting special events for business purposes; Providing in-person forums in the field of business; Arranging and conducting business competitions for entrepreneurs to compete for seed capital to finance business activities. Fundraising; Financial sponsorship; Financial patronage; Financial research; Providing financial information; Financial research in the field of economics; Charitable fundraising; Financing of projects relating to the fight against poverty; Investment of funds; Financial evaluation; Conducting financial feasibility studies; Financial analysis and consultation; Providing grants for charitable purposes; Providing project grants for initiatives; Accepting and administering monetary charitable contributions. Education; Providing of training; Educational research; Library services; Research library services; Online academic library services; Providing educational mentoring services and programs; Online publication of blogs; Online journals, namely, blogs featuring news and commentary in the fields of education, economic policy, social policy, governmental regulations, governance, technology, environmental topics, research, scientific research, agriculture, climate change, energy, finance, business, entrepreneurship, gender issues, health topics, labor and employment, social protection, and social reform; Publication of newsletters; Providing online newsletters in the fields of education, economic policy, social policy, governmental regulations, governance, technology, environmental topics, research, scientific research, agriculture, climate change, energy, finance, business, entrepreneurship, gender issues, health topics, labor and employment, social protection, and social reform; Education services, namely, providing non-downloadable webinars in the fields of education, economic policy, social policy, governmental regulations, governance, technology, environmental topics, research, scientific research, agriculture, climate change, energy, finance, business, entrepreneurship, gender issues, health topics, labor and employment, social protection, and social reform; Production of podcasts; Providing podcasts in the fields of education, economic policy, social policy, governmental regulations, governance, technology, environmental topics, research, scientific research, agriculture, climate change, energy, finance, business, entrepreneurship, gender issues, health topics, labor and employment, social protection, and social reform; Arranging and conducting in-person educational forums in the fields of education, economic policy, social policy, governmental regulations, governance, technology, environmental topics, research, scientific research, agriculture, climate change, energy, finance, business, entrepreneurship, gender issues, health topics, labor and employment, social protection, and social reform; Providing courses of instruction and training relating to public policy initiatives.
69.
High-Throughput Expansion Microscopy, Devices for Use With a Well Plate and Methods for Processing a Sample
Aspects of the present disclosure are directed to a device configured to be inserted into a well plate. The device may include a main body having a top side and a bottom side, and a plurality of posts extending downwardly from the bottom side of the main body, where the plurality of posts is sized to be inserted into a well plate. The device may further include a plurality of post passageways extending through the plurality of posts. The plurality of posts each have a terminus end opposite the main body, where the terminus ends of the plurality of posts further include a plurality of tapered tips. The present disclosure is also directed to methods of processing a plurality of samples in a well plate using the above-described device.
Compositions for local delivery of a drug to an intracranial region, such as brain tissue or a brain tumor. Methods for locally delivering drug or therapy to an intracranial region. Compositions may include a hydrogel in which a chemotherapy drug or immunotherapy drug is dispersed. Kits that include compositions or solutions that may be combined to form compositions.
A61K 31/704 - Composés ayant des radicaux saccharide liés à des composés non-saccharide par des liaisons glycosidiques liés à un composé carbocyclique, p. ex. phloridzine liés à un système carbocyclique condensé, p. ex. sennosides, thiocolchicosides, escine, daunorubicine, digitoxine
A61K 47/34 - Composés macromoléculaires obtenus par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyesters, acides polyaminés, polysiloxanes, polyphosphazines, copolymères de polyalkylène glycol ou de poloxamères
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
Existing clinically adopted epicardial pacing leads mostly rely on surgical suturing or insertion of electrodes to the heart tissue. However, these approaches can cause tissue trauma during application and/or retrieval of the implants, potentially causing detrimental complications such as bleeding, tissue damage, and/or device failure. The present invention reports a bioadhesive epicardial pacing lead for atraumatic epicardial monitoring and stimulation of the heart in vivo to overcome the limitations of existing bioelectronic implants. The bioadhesive pacing lead is composed of an insulation layer, a conductive bioadhesive interface, a built-in reservoir, an electrode lead wire, and a fluidic channel. The bioadhesive pacing lead shows robust mechanical and electrical properties, biocompatibility, continuous epicardial monitoring and pacing capability, and rapid on-demand atraumatic employment and removal.
e.g.e.g., hydrogels formed by crosslinking. Such hydrogels can provide robust gelation and adhesion, while retaining bioactivity. The hydrogel of the disclosure can be implemented in many applications, for non-limiting example, antifouling and lubricious coatings, tissue adhesives, and wound dressings. The hydrogel offers desirable biocompatibility, bioactivity, biodegradability, and mechanical properties.
C08J 3/24 - Réticulation, p. ex. vulcanisation, de macromolécules
A61K 47/60 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif l’ingrédient non actif étant chimiquement lié à l’ingrédient actif, p. ex. conjugués polymère-médicament l’ingrédient non actif étant un agent de modification l’agent de modification étant un composé organique macromoléculaire, p. ex. une molécule oligomérique, polymérique ou dendrimérique obtenu par des réactions autres que celles faisant intervenir uniquement des liaisons non saturées carbone-carbone, p. ex. polyurées ou polyuréthanes le composé organique macromoléculaire étant un oligomère, un polymère ou un dendrimère de polyoxyalkylène, p. ex. PEG, PPG, PEO ou polyglycérol
Buckling is a long studied mechanical process that has been tackled from a variety of theoretical and numerical methods over the past two and a half centuries. Modeling buckling behavior of complicated structures—especially new composite material(s) in an expeditious manner remains an open question, which becomes more important as architected and smart materials come into modern consideration. Despite much research, predicting buckling behavior of materials with complex structure and components, such as notched beams of non-homogeneous architected composites, remains non-trivial. The present disclosure addresses the above problem by applying artificial intelligence methods to model physical relationships directly from observational data.
G06N 3/0442 - Réseaux récurrents, p. ex. réseaux de Hopfield caractérisés par la présence de mémoire ou de portes, p. ex. mémoire longue à court terme [LSTM] ou unités récurrentes à porte [GRU]
A system and method are provided for monitoring patients with heart failure. One method may include receiving physiological data associated with a patient. The method may also include determining a data portion satisfying a signal-quality-index condition. The method may also include determining a probability value for the data portion with a model developed, for example, via machine learning using training data. The method may also include determining whether an exacerbation condition is satisfied based on the probability value, and, in response to determining that the exacerbation condition is satisfied, generating and transmitting an exacerbation alert associated with the patient.
A61B 5/00 - Mesure servant à établir un diagnostic Identification des individus
A61B 5/021 - Mesure de la pression dans le cœur ou dans les vaisseaux sanguins
G16H 50/50 - TIC spécialement adaptées au diagnostic médical, à la simulation médicale ou à l’extraction de données médicalesTIC spécialement adaptées à la détection, au suivi ou à la modélisation d’épidémies ou de pandémies pour la simulation ou la modélisation des troubles médicaux
75.
WATER-SOLUBLE TRANS-MEMBRANE PROTEINS AND METHODS FOR THE PREPARATION AND USE THEREOF
G16B 15/20 - Repliement de protéines ou de domaines
C07K 14/705 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire
C07K 14/72 - RécepteursAntigènes de surface cellulaireDéterminants de surface cellulaire pour des hormones
G16B 15/00 - TIC spécialement adaptées à l’analyse de structures moléculaires bidimensionnelles ou tridimensionnelles, p. ex. relations structurelles ou fonctionnelles ou alignement de structures
G16B 35/00 - TIC spécialement adaptées aux bibliothèques combinatoires in silico d’acides nucléiques, de protéines ou de peptides
Compositions, articles, systems, and methods for detection of fluorocarbons are generally described. In certain embodiments, for example, a sensing material that comprises a coupled-multichromophore is described. The coupled-multichromophore may be capable of energy transport and/or diffusion between individual sites of the coupled-multichromophore. In certain embodiments, for example, the coupled-multichromophore comprises individual sites that are linked through delocalized orbitals such that the coupled-multichromophore is capable of energy transport and/or diffusion through each individual site of the coupled-multichromophore. The sensing material comprising the coupled-multichromophore may be configured to detect the presence of an analyte, such as a fluoroalkyl species (e.g., a per- and/or polyfluoroalkyl substance). For example, in some embodiments, the coupled-multichromophore comprises at least one chromophore that displays a change in electromagnetic radiation (e.g., light) emission in response to a presence of the analyte. The change in electromagnetic radiation emission may be detected to determine the presence of the analyte.
G01N 21/78 - Systèmes dans lesquels le matériau est soumis à une réaction chimique, le progrès ou le résultat de la réaction étant analysé en observant l'effet sur un réactif chimique produisant un changement de couleur
A fundamental new effect in nonlinear photonic systems is disclosed herein, called n-photon bound states in the continuum, which can be applied to deterministically create large Fock states, as well as very highly intensity-squeezed states of light. The effect is one in which destructive interference gives a certain quantum state of light an infinite lifetime, despite coexisting in frequency with a radiative continuum. For Kerr nonlinear systems, that state is an n-photon (Fock) state of a particular and tunable n. Experimentally-realizable examples are shown which are capable of producing n-photon Fock states, and states with very large intensity squeezing, such as greater than 10 dB. The effect requires only Kerr nonlinearity and linear frequency-dependent (non-Markovian) dissipation, and is, in principle, applicable at any frequency. The theory and concepts are also immediately applicable to nonlinear bosons besides photons, and thus may be implemented in many other disciplines.
Systems and methods described herein relate to using multimodal foundation models. In one embodiment, a method includes receiving images and a foundation multi-model, selecting a mask set, modifying the foundation multi-model to include query, key, and value matrices, and applying the mask set to the foundation multi-model to obtain patch-aligned features.
G06F 30/15 - Conception de véhicules, d’aéronefs ou d’embarcations
B60W 50/06 - Détails des systèmes d'aide à la conduite des véhicules routiers qui ne sont pas liés à la commande d'un sous-ensemble particulier pour améliorer la réponse dynamique du système d'aide à la conduite, p. ex. pour améliorer la vitesse de régulation, ou éviter le dépassement de la consigne ou l'instabilité
B60W 60/00 - Systèmes d’aide à la conduite spécialement adaptés aux véhicules routiers autonomes
79.
TOX INHIBITORS AND MOLECULAR GLUES, METHODS OF USE THEREOF, AND KITS COMPRISING THE SAME
Disclosed herein are compounds (e.g, compounds of Formula (I), and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, isotopically labeled compounds, and prodrugs thereof), and pharmaceutical compositions, kits, methods, and uses thereof. The compounds disclosed herein are inhibitors of TOX protein and are useful for treating diseases (e.g., immune diseases, proliferative diseases, and viral infections).
A61P 37/00 - Médicaments pour le traitement des troubles immunologiques ou allergiques
C07D 221/16 - Systèmes cycliques à trois cycles contenant des carbocycles autres que des cycles à six chaînons
C07D 401/04 - Composés hétérocycliques contenant plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle, au moins un cycle étant un cycle à six chaînons avec un unique atome d'azote contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 405/04 - Composés hétérocycliques contenant à la fois un ou plusieurs hétérocycles comportant des atomes d'oxygène comme uniques hétéro-atomes du cycle et un ou plusieurs hétérocycles comportant des atomes d'azote comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
C07D 409/04 - Composés hétérocycliques contenant plusieurs hétérocycles, au moins un cycle comportant des atomes de soufre comme uniques hétéro-atomes du cycle contenant deux hétérocycles liés par une liaison directe de chaînon cyclique à chaînon cyclique
A61K 31/435 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle
C07C 237/22 - Amides d'acides carboxyliques, le squelette carboné de la partie acide étant substitué de plus par des groupes amino ayant les atomes de carbone des groupes carboxamide liés à des atomes de carbone acycliques du squelette carboné ayant des atomes d'azote de groupes amino liés au squelette carboné de la partie acide, en outre acylés
A61K 47/00 - Préparations médicinales caractérisées par les ingrédients non actifs utilisés, p. ex. les supports ou les additifs inertesAgents de ciblage ou de modification chimiquement liés à l’ingrédient actif
C07C 323/60 - Thiols, sulfures, hydropolysulfures ou polysulfures substitués par des halogènes, des atomes d'oxygène ou d'azote ou par des atomes de soufre ne faisant pas partie de groupes thio contenant des groupes thio et des groupes carboxyle liés au même squelette carboné ayant les atomes de soufre des groupes thio liés à des atomes de carbone acycliques du squelette carboné avec l'atome de carbone d'au moins un des groupes carboxyle lié à des atomes d'azote
Described herein are systems and methods for improving the performance of and compliance with wearable garments. In some embodiments, a system comprises one or more sensors integrated within a wearable garment. The sensors are configured to generate data responsive to pressure exerted by the wearable garment on a user; and one or more processors coupled to the one or more sensors. The processors are configured to process the generated data to determine a duration of use of the wearable garment by the user; and in response to determining that the duration of use is less than a predetermined duration of use threshold, generating one or more notifications.
A41D 31/04 - Matériaux spécialement adaptés aux vêtements de dessus caractérisés par une fonction ou une utilisation particulières
A61F 13/08 - Bas élastiquesBandages ou pansementsGarnitures absorbantes spécialement conçus pour les pieds ou les jambesCoussinets pour corsAnneaux pour cors pour comprimer les anévrismes
82.
APPARATUS, SYSTEMS AND METHODS FOR CONTINUOUS RNA MANUFACTURING
The present invention provides apparatus, systems, and methods for continuous manufacturing of RNA utilizing in-line monitoring of the in vitro transcription reaction and related downstream processes, including chromatography and filtration processes.
C12M 1/34 - Mesure ou test par des moyens de mesure ou de détection des conditions du milieu, p. ex. par des compteurs de colonies
C12M 1/00 - Appareillage pour l'enzymologie ou la microbiologie
C12M 1/36 - Appareillage pour l'enzymologie ou la microbiologie comportant une commande sensible au temps ou aux conditions du milieu, p. ex. fermenteurs commandés automatiquement
The Trustees of Columbia University in the City of New York (USA)
Inventeur(s)
Chi, Cheng
Feng, Siyuan
Du, Yilun
Xu, Zhenjia
Cousineau, Eric A.
Burchfiel, Benjamin
Song, Shuran
Abrégé
A method includes receiving observation data comprising sensor data associated with a robot while one or more humans are controlling the robot to perform a specified task, receiving control data comprising control commands input by the one or more humans while controlling the robot to perform the specified task, adding Gaussian noise to the control data to generate noisy control data, and training a neural network, based on the noisy control data to receive the observation data and first Gaussian noise, and output an action sequence, comprising a plurality of action steps, to be performed by the robot to perform the specified task.
Methods and systems for evaluating performance of classifier models trained on noisy labels. Using predicted labels for a classifier model, noisy labels, and parameters of the model, a probability of detection and/or a probability of false alarm are determined. Additional predicted labels and/or additional correct labels may also be used to determine the probabilities. A performance evaluation of the trained classifier model is output based on the at least one of the representation of the probability of detection and/or the representation of the probability of false alarm. Using the performance evaluation, it may be determined whether to deploy or undeploy the trained classifier model. Classifier models may be deployed to a classification environment where input data for a classifier model is received and one or more labels are applied to the input data using the classifier model.
A method and device for stimulating cerebrospinal fluid flow is disclosed. The method may include acquiring an electroencephalography (EEG) signal from a human subject, predicting a target feature of the EEG based on the EEG signal, and playing an auditory stimulus to coincide with the target feature of the EEG learned by a neural network. The target feature may include a peak of a slow wave. The method may include using a recurrent neural network to predict the target feature for a human subject.
G16H 40/63 - TIC spécialement adaptées à la gestion ou à l’administration de ressources ou d’établissements de santéTIC spécialement adaptées à la gestion ou au fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement d’équipement ou de dispositifs médicaux pour le fonctionnement local
87.
MICRO-INVASIVE NEURAL SYSTEM FOR DELIVERING THERAPEUTIC AGENTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
ABSTRACT Systems and methods for treating neurological disorders, such as epilepsy, where a drug delivery device is implanted adjacent to a micro-region within the brain for local administration of a drug thereto, where local administration of the drug into the micro-region is effective to treat the neurological disorder while substantially avoiding adverse side effects.
A61M 37/00 - Autres appareils pour introduire des agents dans le corpsPercutanisation, c.-à-d. introduction de médicaments dans le corps par diffusion à travers la peau
A61B 34/20 - Systèmes de navigation chirurgicaleDispositifs pour le suivi ou le guidage d'instruments chirurgicaux, p. ex. pour la stéréotaxie sans cadre
88.
EVERTING FLEXIBLE INFLATABLE STRUCTURES FOR ASSISTING SUBJECTS
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (USA)
Inventeur(s)
Barhydt, Kentaro
Osele, Obumneme Godson
Okamura, Allison
Asada, Haruhiko
Abrégé
Disclosed herein are everting devices including flexible inflatable structures configured to safely and efficiently lift a subject or other object from a supporting surface. In some embodiments, a flexible inflatable structure may be configured to form a sling used to lift a subject or other object. In other embodiments, everting devices may include end effectors that are everted through an internal channel of a flexible inflatable structure to an exterior everted portion of the flexible inflatable structure as the everting device is transitioned to the fully everted configuration. In other embodiments, a wheelchair may include an everting device with a flexible inflatable structure that is configured to form at least a portion of a seat of the wheelchair in the everted configuration.
Electrostatic catalysis in chemical synthesis is known to boost reaction rates and selectively produce certain reaction products. Earlier studies required external electric field (EEF) of more than 10 MV/cm and alignment of EEF with the reaction axis. Such large and oriented EEF is unfeasible for large-scale implementation. Disclosed herein is a method of spontaneously shifting the band energy at the tip of an individual single-walled carbon nanotube (SWCNT) in a high-permittivity growth environment, with its other end in contact with a low work function electrode, such as hafnium carbide or titanium carbide. By adjusting the band energy at a point where there is a substantial disparity in the density of states (DOS) between semiconducting (s-) and metallic (m-) SWCNTs, effective electrostatic catalysis for s-SWCNT growth is achieved. The disclosed method enables the production of high-purity (99.92%) s-SWCNT horizontal arrays with stable chirality twist, aided by weak EEF as a perturbation.
D01F 11/16 - Post-traitement chimique de filaments, ou similaires, faits par l’homme, pendant leur fabrication de carbone par des procédés physico-chimiques
D01F 9/12 - Filaments de carboneAppareils spécialement adaptés à leur fabrication
90.
REMOVING MATERIAL FROM SURFACES AND RELATED ARTICLES AND SYSTEMS
The invention features compositions and methods for treating diseases or disorders associated with undesirable neuronal excitability (e.g., de-myelinating disease, neurodegenerative disease, such as Parkinson's disease or Huntington's disease; or chronic pain, or epilepsy).
A61K 48/00 - Préparations médicinales contenant du matériel génétique qui est introduit dans des cellules du corps vivant pour traiter des maladies génétiquesThérapie génique
A61N 5/06 - Thérapie par radiations utilisant un rayonnement lumineux
Current measurements for avalanche forecasting are usually taken by digging snow pits or probing. These methods are mostly either fast and qualitative or slow and quantitative. The method disclosed herein offers an approach that is both fast and quantitative and could be useful to backcountry skiers and ski patrollers. The air-dropped system disclosed herein would also be useful for characterizing snow water content, which is useful for estimating city water supplies, particularly in draught-stricken places. Existing ways of measuring sown water content involve taking precise density measurements in particular locations, but these air-dropped techniques could be performed over a much wider area to get a better idea of the distribution of the water content, leading to better estimates of city water supply.
Nanoelectronic devices and bioelectronic hybrids thereof are described herein. Methods of making and using such devices and hybrids are also described. The nanoelectronic devices and bioelectronic hybrids can be used, for example, in medical applications. For example, the bioelectronic hybrids can be non-surgically implanted to provide stimulation or modulation to a target site or region in a subject.
The invention relates to a method for producing a stacked structure comprising a layer of semiconductor material bonded to a substrate, which comprises: producing a heterostructure by: • forming an intermediate layer made of a two-dimensional material on a growth substrate (1); patterning the intermediate layer with a plurality of openings to form a patterned intermediate layer (3); growing a semiconductor material on the patterned intermediate layer (3) by epitaxial lateral overgrowth to form a continuous epitaxial layer (4) on the patterned intermediate layer; forming a first assembly by bonding the heterostructure to a handling substrate (6), the continuous epitaxial layer being located at the bonding interface; separating the first assembly at the patterned intermediate layer (3) so as to obtain a second assembly resulting from transferring the continuous epitaxial layer (4) from the heterostructure to the handling substrate (6).
H01L 21/02 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives
H01L 21/18 - Fabrication ou traitement des dispositifs à semi-conducteurs ou de leurs parties constitutives les dispositifs ayant des barrières de potentiel, p. ex. une jonction PN, une région d'appauvrissement ou une région de concentration de porteurs de charges les dispositifs ayant des corps semi-conducteurs comprenant des éléments du groupe IV du tableau périodique, ou des composés AIIIBV, avec ou sans impuretés, p. ex. des matériaux de dopage
A thermal energy storage system includes a firebrick checkerwork and an electrode. The firebrick checkerwork includes one or more conductive firebrick layers, each including a plurality of electrically conductive doped metal oxide firebricks with one or more airflow vents. The electrode includes one or more electrode firebrick layers, each layer including a plurality of electrode firebricks. The firebrick checkerwork is heated due to application of electrical power to the electrode. Air flowing through the firebrick checkerwork may then be heated for use in heat-related applications (e.g., an industrial application, commercial application, residential application, transportation application, etc.) some of which may relate to electricity production or in other applications which may relate to other purposes that require heat that are unrelated to electricity production.
The determination of chemical mixture components is vital to a multitude of scientific fields. Oftentimes various spectroscopic methods are employed to decipher the molecular composition of these complex mixtures. The sheer density of spectral features of different molecules present in such observations may make unambiguous assignment to individual species using these methods challenging. Yet, components of a mixture are commonly chemically related due to environmental processes or shared precursor molecules. Therefore, along with investigating the spectroscopic signals, analysis of the structural and chemical relevance of a molecule is an important consideration when determining which species are present in a mixture. Machine-learning molecular embedding methods are used with a relevance module to determine the likelihood of a molecule being present in a mixture based on the other known species, chemical priors, and spectroscopic information. By incorporating this metric, the mixture components can be identified with extremely high accuracy (∼ 97%).
G01N 24/08 - Recherche ou analyse des matériaux par l'utilisation de la résonance magnétique nucléaire, de la résonance paramagnétique électronique ou d'autres effets de spin en utilisant la résonance magnétique nucléaire
G16B 40/00 - TIC spécialement adaptées aux biostatistiquesTIC spécialement adaptées à l’apprentissage automatique ou à l’exploration de données liées à la bio-informatique, p. ex. extraction de connaissances ou détection de motifs
97.
METHODS AND MATERIALS TO DISTINGUISH BETWEEN ACTIVE EOSINOPHILIC ESOPHAGITIS (EOE), EOE IN REMISSION, AND NON-EOE STATES
The invention provides methods for diagnosing eosinophilic esophagitis (EoE) in a subject and methods for determining an EoE state (active or remission) in a subject. The methods include detecting elevated expression levels of GPR15 protein or a fragment thereof and/or CD38 protein or a fragment thereof in a biological sample from the subject. Panels, compositions, and kits are also provided.
G01N 33/68 - Analyse chimique de matériau biologique, p. ex. de sang ou d'urineTest par des méthodes faisant intervenir la formation de liaisons biospécifiques par ligandsTest immunologique faisant intervenir des protéines, peptides ou amino-acides
C07K 16/28 - Immunoglobulines, p. ex. anticorps monoclonaux ou polyclonaux contre du matériel provenant d'animaux ou d'humains contre des récepteurs, des antigènes de surface cellulaire ou des déterminants de surface cellulaire
C12Q 1/6883 - Produits d’acides nucléiques utilisés dans l’analyse d’acides nucléiques, p. ex. amorces ou sondes pour les maladies provoquées par des altérations du matériel génétique
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Medical information; Providing medical information; Health care services, namely, providing a database in the fields of medical research, medical research data, life sciences, and medical technology, featuring the collection of data and information for diagnostic and treatment purposes
Providing an online database featuring business intelligence in the fields of medical science, medical research and data, medical technology, scientific research and data, and life sciences; business management services, namely, administration of competitions in the fields of business, medical research, scientific research, medical technology, scientific technology, and life sciences; database management
