The present invention is directed respirable, dry powder particle formulations of lung surfactants that optionally comprise surfactant proteins and/or polypeptide and that are formulated for delivery to the pulmonary system via inhalation.
Medical apparatus and units for dosing, namely, drug delivery devices that facilitate delivery of a wide range of pharmaceuticals; Medical apparatus and units for dosing, namely, drug delivery devices that deliver drugs and agents to the pulmonary system; all of the aforementioned goods used in the treatment of diseases, disorders and conditions in humans
The present invention is directed respirable, dry powder particle formulations of lung surfactants that optionally comprise surfactant proteins and that are formulated for delivery to the pulmonary system via inhalation.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 38/17 - Peptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'animauxPeptides ayant plus de 20 amino-acidesGastrinesSomatostatinesMélanotropinesLeurs dérivés provenant d'humains
The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders.
The present invention provides methods of providing rapid relief of motor fluctuations in a Parkinson's disease patient. The methods of the invention comprise pulmonary administration of levodopa by inhalation at therapeutically effective concentrations such that the patient's plasma levodopa concentration increases by at least about 200 ng/ml within 10 minutes or less post inhalation as compared to the concentration of levodopa in the patient's plasma prior to inhalation of the levodopa and wherein the patient's plasma concentration remains increased by at least about 200 ng/ml for a time period of at least 15 minutes after inhalation. The methods of the invention are particularly useful for treatment of motor fluctuations which arise as a result of poorly controlled levodopa plasma levels in a patient.
A61K 31/197 - Acides carboxyliques, p. ex. acide valproïque ayant un groupe amino les groupes amino et carboxyle étant liés à la même chaîne carbone acyclique, p. ex. acide gamma-aminobutyrique [GABA], bêta-alanine, acide epsilon-aminocaproïque ou acide pantothénique
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting public awareness of the need for education, research, treatment and a cure for diseases, disorders and conditions Entertainment and educational services, namely, providing live and online seminars, conferences and workshops concerning issues related to diseases, disorders and conditions and distributing informational course materials in connection therewith Providing health information; providing information and online information relating to diagnostic, prophylactic and therapeutic properties of pharmaceutical preparations for the prevention and treatment of diseases, disorders and conditions
An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of spinal cord injuries, multiple sclerosis and other diseases, disorders or conditions of the nervous system
36 - Services financiers, assurances et affaires immobilières
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting public awareness via promotional campaigns regarding Parkinson's disease; excluding information technology services in the form of artificial intelligence or automated voice-response Conducting fundraising campaigns to support Parkinson's disease Providing health information regarding Parkinson's disease; excluding information technology services in the form of artificial intelligence or automated voice-response
10.
DEVICES AND METHODS FOR PUNCTURING A CAPSULE TO RELEASE A POWDERED MEDICAMENT THEREFROM
A device for puncturing a capsule to release a powdered medicament therefrom includes a chamber for receiving the capsule. The capsule includes opposing domes and a cylindrical wall portion defined by a capsule wall radius r. The device further includes a mechanism for puncturing at least one hole in at least one dome. A center of each hole is located within an annular puncture region situated at no less than 0.4 r, and a total surface area of all puncture holes is between about 0.5% and about 2.2% of a total surface area of the capsule. The annular puncture region may, for example, be situated between about 0.4 r and about 0.8 r, or between about 0.4 r and about 0.6 r.
The invention provides respirable dry powder particle formulations comprising polynucleotides preferably prepared by spray drying for delivery to the pulmonary system via inhalation. Preferably, the polynucleotide is RNA.
A61K 31/7105 - Acides ribonucléiques naturels, c.-à-d. contenant uniquement des riboses liés à l'adénine, la guanine, la cytosine ou l'uracile et ayant des liaisons 3'-5' phosphodiester
The present invention is directed respirable, dry powder particle formulations of lung surfactants that optionally comprise surfactant proteins and that are formulated for delivery to the pulmonary system via inhalation.
A61K 31/685 - Diesters d'acide du phosphore avec deux composés hydroxyle, p. ex. phosphatidylinositols un des composés hydroxylés ayant des atomes d'azote, p. ex. phosphatidylsérine, lécithine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
A61K 47/10 - AlcoolsPhénolsLeurs sels, p. ex. glycérolPolyéthylène glycols [PEG]PoloxamèresAlkyléthers de PEG/POE
A61K 47/12 - Acides carboxyliquesLeurs sels ou anhydrides
A61K 47/18 - AminesAmidesUréesComposés d’ammonium quaternaireAcides aminésOligopeptides ayant jusqu’à cinq acides aminés
A61K 47/26 - Hydrates de carbone, p. ex. polyols ou sucres alcoolisés, sucres aminés, acides nucléiques, mono-, di- ou oligosaccharidesLeurs dérivés, p. ex. polysorbates, esters d’acide gras de sorbitan ou glycyrrhizine
A61K 47/36 - PolysaccharidesLeurs dérivés, p. ex. gommes, amidon, alginate, dextrine, acide hyaluronique, chitosane, inuline, agar-agar ou pectine
A61K 47/42 - ProtéinesPolypeptidesLeurs produits de dégradationLeurs dérivés p. ex. albumine, gélatine ou zéine
C07K 14/785 - Peptides du surfactif alvéolairePeptides du surfactif pulmonaire
13.
RAPID RELIEF OF MOTOR FLUCTUATIONS IN PARKINSON'S DISEASE
The present invention provides methods for treating OFF episodes in a Parkinson's Disease patient comprising administering levodopa to the pulmonary system of a patient wherein after administration, the patient's Unified Parkinson's Disease Rating Scale (UPDRS) Part 3 score is improved by, for example, at least about 5 points as compared to placebo control and/or as compared to the patient's UDPRS Part 3 score prior to administration. The invention also provides methods of reducing mean daily OFF time in a Parkinson's patient.
36 - Services financiers, assurances et affaires immobilières
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing a website featuring information in the fields of patient financial assistance, reimbursement and insurance coverage for pharmaceuticals; providing information in the fields of patient financial assistance, reimbursement and insurance coverage for pharmaceuticals Providing health information
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Entertainment and educational services, namely, providing live and online seminars, conferences and workshops concerning issues related to diseases, disorders and medical conditions and distributing informational course materials in connection therewith Providing health information; providing information and online information relating to diagnostic, prophylactic and therapeutic properties of pharmaceutical preparations for the prevention and treatment of diseases, disorders and conditions
36 - Services financiers, assurances et affaires immobilières
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing a website featuring information in the fields of patient financial assistance, reimbursement and insurance coverage for pharmaceuticals; providing information in the fields of patient financial assistance, reimbursement and insurance coverage for pharmaceuticals Providing health information
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system Medical devices, namely, drug delivery system in the nature of an inhaler for medical purposes, sold empty, that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Providing medical and scientific research information in the field of clinical trials for pharmaceuticals used in the treatment of neurological diseases, disorders and conditions in patients
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting public awareness of the need for education, research, treatment and a cure for diseases, disorders and conditions Entertainment and educational services, namely, providing live and online seminars, conferences and workshops concerning issues related to neurological diseases, disorders and conditions and distributing informational course materials in the nature of brochures, pamphlets and other written materials in connection therewith Providing health information
The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for administration to the respiratory system of a patient for the treatment of a variety of disease conditions comprise a mass of biocompatible particles comprising an active agent, and a hydrogenated starch hydrosylate (HSH). The improvement over the prior art comprises the presence of HSH in the pharmaceutical formulation. The invention further relates to a method of treating diseases comprising administering the pharmaceutical formulations of the present invention to the respiratory system of a patient in need of treatment.
A61K 31/58 - Composés contenant des systèmes cycliques du cyclopenta[a]hydrophénanthrèneLeurs dérivés, p. ex. stéroïdes contenant des hétérocycles, p. ex. danazol, stanozolol, pancuronium ou digitogénine
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Educational services, namely, conducting programs in the fields of treatments for Parkinson's disease and distribution of course and educational materials in connection therewith Providing health information to healthcare providers concerning the treatment of Parkinson's disease
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Educational services, namely, providing live and online seminars, conferences and workshops concerning issues related to diseases, disorders or conditions of the nervous system and distributing informational course materials in connection therewith Providing health information
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Educational services, namely, providing live and online seminars, conferences and workshops concerning issues related to diseases, disorders or conditions of the nervous system and distributing informational course materials in connection therewith Providing health information
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological disorders or conditions
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing public awareness campaigns featuring information to promote public awareness regarding Parkinson's disease; excluding information technology services in the form of artificial intelligence or automated voice-response. Providing health information regarding Parkinson's disease; excluding information technology services in the form of artificial intelligence or automated voice-response.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing public awareness campaigns featuring information to promote public awareness regarding Parkinson's disease; excluding information technology services in the form of artificial intelligence or automated voice-response. Providing health information regarding Parkinson's disease; excluding information technology services in the form of artificial intelligence or automated voice-response.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system
The present invention generally relates to sustained release 4-aminopyridine tablets, which include a core and a coating. The sustained release tablets of the invention are generally suitable for once daily oral administration for the treatment of neurological disorders.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing campaigns featuring information to promote public awareness regarding Parkinson's disease Providing health information regarding Parkinson's disease
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing campaigns featuring information to promote public awareness regarding Parkinson's disease Providing health information regarding Parkinson's disease
41 - Éducation, divertissements, activités sportives et culturelles
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Educational services, namely, conducting programs in the fields of treatments for Parkinson's disease and distribution of course and educational materials in connection therewith Providing health information to healthcare providers concerning the treatment of Parkinson's disease
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing campaigns featuring information to promote public awareness regarding Parkinson's disease Providing health information regarding Parkinson's disease
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
Drug delivery agents consisting of compounds that facilitate delivery of a wide range of pharmaceuticals; Drug delivery agents in the form of capsules that deliver drugs to the pulmonary system; Drug delivery agents in the form of powders that deliver drugs to the pulmonary system; all of the afore-mentioned goods used for the treatment of Parkinson's disease, inflammatory disorders, asthma, pain and central nervous system disorders. Drug delivery devices that facilitate delivery of a wide range of pharmaceuticals; Drug delivery devices that deliver drugs and agents to the pulmonary system; all of the aforementioned goods used in the treatment of diseases, disorders and conditions in humans. Pharmaceutical drug development services, namely, the development of drug delivery devices and pharmaceutical products to the pulmonary system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
42 - Services scientifiques, technologiques et industriels, recherche et conception
Produits et services
(1) Drug delivery agents for the treatment of asthma, inflammatory diseases, pain, Parkinson's Disease, multiple sclerosis, Alzheimer's Disease, epilepsy and other diseases, disorders and conditions of the nervous system, namely brain, movement, ocular mobility, autoimmune, and spinal cord diseases, disorders and conditions
(2) Medical devices to deliver pharmaceutical and biological preparations used in the treatment of asthma, inflammatory diseases, pain, Parkinson's Disease, multiple sclerosis, Alzheimer's Disease, epilepsy and other diseases, disorders and conditions of the nervous system, namely brain, movement, ocular mobility, autoimmune, and spinal cord diseases, disorders and conditions (1) Pharmaceutical drug development services, namely, the development of drug delivery devices and pharmaceutical products to the pulmonary system
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations for use in dermatology; pharmaceutical preparations namely a gel, cream or ointment designed to improve the appearance of scars, blemishes and other skin imperfections
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Providing campaigns featuring information to promote public awareness regarding Parkinson's disease
(2) Providing health information regarding Parkinson's disease
40.
Dosator apparatus for filling a capsule with dry powder
The invention relates to a dosator which comprises a tapered elongate cavity; a stationary plunger disposed within the cavity; a removable mesh screen disposed between the stationary plunger and the bottom of the dosator; a dosator chamber defined between the mesh screen and the bottom of the dosator for receiving powder from a powder source and holding the powder until it is expelled into the capsule; at least one vacuum pump operably linked to the dosator and capable of drawing dry powder into the dosator chamber from a powder source, compacting the powder into a slug of powder having a predetermined bulk density; and at least one source of positive pressure operably linked to the dosator and capable of providing positive pressure to expel the powder slug from the dosator and methods of filling capsules.
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
B65B 63/02 - Dispositifs accessoires, non prévus ailleurs, opérant sur des objets ou matériaux à emballer pour comprimer ou tasser les objets ou matériaux à emballer avant de les emballer ou de les introduire dans des réceptacles ou récipients
B65B 1/16 - Procédés ou moyens pour remplir les réceptacles ou les récipients avec le matériau par des moyens pneumatiques, p. ex. par aspiration
B65B 1/26 - Réduction du volume du matériau à remplir par des moyens pneumatiques, p. ex. aspiration
B65B 1/36 - Dispositifs ou procédés pour régler ou déterminer la quantité ou la qualité du matériau fourni ou chargé par dispositifs ou procédés volumétriques
A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Providing campaigns featuring information to promote public awareness regarding Parkinson's disease
(2) Providing health information regarding Parkinson's disease
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Pharmaceutical products, namely, pharmaceutical and biological preparations for the treatment of diseases, disorders and conditions of the nervous system namely brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions; pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease and epilepsy.
(2) Medical devices, namely inhaler and nebulizer delivery devices that facilitate delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders and conditions of the nervous system. (1) Providing health information about issues related to diseases, disorders and conditions of the central nervous system.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
(1) Providing health information and online health information relating to diagnostic, prophylactic and therapeutic properties of pharmaceutical preparations for the prevention and treatment of diseases, disorders and conditions of the central nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system. Medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system. Providing health information.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing campaigns featuring information to promote public awareness regarding Parkinson's disease. Providing health information regarding Parkinson's disease.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical products, namely, pharmaceutical and biological preparations for the treatment of diseases, disorders and conditions of the nervous system namely brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions; pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease and epilepsy.
(2) Medical devices, namely inhaler and nebulizer delivery devices that facilitate delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders and conditions of the nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical products, namely, pharmaceutical and biological preparations for the treatment of diseases, disorders and conditions of the nervous system namely brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions; pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease and epilepsy.
(2) Medical devices, namely inhaler and nebulizer delivery devices that facilitate delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders and conditions of the nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system. Medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical products, namely, pharmaceutical and biological preparations for the treatment of diseases, disorders and conditions of the nervous system namely brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions; pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease and epilepsy.
(2) Medical devices, namely inhaler and nebulizer delivery devices that facilitate the delivery of pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease, epilepsy, and brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
(1) Pharmaceutical products, namely, pharmaceutical and biological preparations for the treatment of diseases, disorders and conditions of the nervous system namely brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions; pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease and epilepsy.
(2) Medical devices, namely inhaler and nebulizer delivery devices that facilitate delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders and conditions of the nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the human central nervous system, namely Parkinson’s disease. Medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the human central nervous system, namely Parkinson’s disease.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system. Medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system; none of the aforementioned goods for use with electroencephalogram (EEG) or other neurophysiological testing, monitoring or analysis. Medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system; none of the aforementioned goods for use with electroencephalogram (EEG) or other neurophysiological testing, monitoring or analysis.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system Providing health information
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system
An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.
41 - Éducation, divertissements, activités sportives et culturelles
42 - Services scientifiques, technologiques et industriels, recherche et conception
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Promoting public awareness of the need for education, research, treatment and a cure for diseases, disorders and conditions. Providing an online forum for transmission of messages concerning issues related to neurological diseases, disorders or conditions. Entertainment and educational services, namely, providing live and online seminars, conferences and workshops concerning issues related to diseases, disorders and conditions and distributing informational course materials in connection therewith. Hosting an on-line community website featuring information related to neurologic disorders; computer services, namely, creating an on-line community for registered users to participate in discussions, get feedback from their peers, form virtual communities, and engage in social networking concerning issues related to neurologic disorders; Providing a website featuring technology that enables users to search, watch, share, and comment on documents, videos, audio and other multimedia content concerning issues related to neurologic disorders. Providing health information; providing information and online information relating to diagnostic, prophylactic and therapeutic properties of pharmaceutical preparations for the prevention and treatment of diseases, disorders and conditions.
The invention provides stable, spray-dried, particle formulations containing rapamycin, or pharmaceutically acceptable salts of rapamycin, which are useful for pulmonary administration to the respiratory tract of a patient for the treatment of disease.
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/436 - Composés hétérocycliques ayant l'azote comme hétéro-atome d'un cycle, p. ex. guanéthidine ou rifamycines ayant des cycles à six chaînons avec un azote comme seul hétéro-atome d'un cycle condensés en ortho ou en péri avec des systèmes hétérocycliques le système hétérocyclique contenant un cycle à six chaînons ayant l'oxygène comme hétéro-atome du cycle, p. ex. rapamycine
(1) Medical devices, namely inhaler and nebulizer delivery devices that facilitate delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders and conditions of the nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Pharmaceutical products, namely, pharmaceutical and biological preparations for the treatment of diseases, disorders and conditions of the nervous system namely brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions; pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease and epilepsy.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system. Medical devices, namely delivery devices that facilitate delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Pharmaceutical products, namely, pharmaceutical and biological preparations for the treatment of diseases, disorders and conditions of the nervous system namely brain, movement, ocular motility, autoimmune and spinal cord diseases, disorders and conditions; pharmaceutical and biological preparations for the treatment of Parkinson's Disease, multiple sclerosis, Alzheimer's Disease and epilepsy
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system. Inhalation devices, that facilitate delivery of pharmaceutical products for treating diseases, disorders or conditions of the human central nervous system including Parkinson's disease.
73.
Methods for reducing inter-patient variability of levodopa plasma concentrations
The present invention provides methods of reducing the inter-patient variability of levodopa plasma concentrations in a population of Parkinson's disease patients. The methods of the invention comprise pulmonary administration of levodopa at therapeutically effective concentrations such that the inter-patient variability of levodopa plasma concentrations at time periods ranging from about 10 minutes post inhalation to about 60 minutes or more post inhalation have less than a 50% coefficient variation. The methods of the invention are particularly useful for treatment of motor fluctuations which arise as a side effect of L-Dopa therapy.
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 45/06 - Mélanges d'ingrédients actifs sans caractérisation chimique, p. ex. composés antiphlogistiques et pour le cœur
A61K 47/24 - Composés organiques, p. ex. hydrocarbures naturels ou synthétiques, polyoléfines, huile minérale, gelée de pétrole ou ozocérite contenant des atomes autres que des atomes de carbone, d'hydrogène, d'oxygène, d'halogènes, d'azote ou de soufre, p. ex. cyclométhicone ou phospholipides
The invention relates to a dosator which comprises a tapered elongate cavity; a stationary plunger disposed within the cavity; a removable mesh screen disposed between the stationary plunger and the bottom of the dosator; a dosator chamber defined between the mesh screen and the bottom of the dosator for receiving powder from a powder source and holding the powder until it is expelled into the capsule; at least one vacuum pump operably linked to the dosator and capable of drawing dry powder into the dosator chamber from a powder source, compacting the powder into a slug of powder having a predetermined bulk density; and at least one source of positive pressure operably linked to the dosator and capable of providing positive pressure to expel the powder slug from the dosator and methods of filling capsules.
A61K 9/48 - Préparations en capsules, p. ex. de gélatine, de chocolat
A61J 3/07 - Dispositifs ou procédés spécialement conçus pour donner à des produits pharmaceutiques une forme physique déterminée ou une forme propre à leur administration la forme de capsules ou de petits conteneurs similaires à absorber par voie buccale
A61K 9/00 - Préparations médicinales caractérisées par un aspect particulier
A61K 31/198 - Alpha-amino-acides, p. ex. alanine ou acide édétique [EDTA]
A61K 9/14 - Préparations médicinales caractérisées par un aspect particulier à l'état particulaire, p. ex. poudres
B65B 63/02 - Dispositifs accessoires, non prévus ailleurs, opérant sur des objets ou matériaux à emballer pour comprimer ou tasser les objets ou matériaux à emballer avant de les emballer ou de les introduire dans des réceptacles ou récipients
B65B 1/16 - Procédés ou moyens pour remplir les réceptacles ou les récipients avec le matériau par des moyens pneumatiques, p. ex. par aspiration
B65B 1/26 - Réduction du volume du matériau à remplir par des moyens pneumatiques, p. ex. aspiration
B65B 1/36 - Dispositifs ou procédés pour régler ou déterminer la quantité ou la qualité du matériau fourni ou chargé par dispositifs ou procédés volumétriques
The present invention provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L. The invention further provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L wherein the capsule material comprises hydroxypropylmethylcellulose (HPMC) and titanium dioxide.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
10 - Appareils et instruments médicaux
Produits et services
Pharmaceutical products, namely, pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system medical devices, namely, drug delivery system that facilitates the delivery of pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system
78.
Capsules containing high doses of levodopa for pulmonary use
The present invention provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L. The invention further provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L wherein the capsule material comprises hydroxypropylmethylcellulose (HPMC) and titanium dioxide.
The present invention relates to improved topical gel compositions comprising an active agent, and uses thereof. The composition comprises skin penetration enhancers, rheology modifiers, solubilization agents and is capable of transdermal delivery of poorly soluble or hydrophobic agents. The actives delivered through the inventive vehicle are antifungal and anti-inflammatory agents such as fluticazone and naftifine.
The present invention provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L. The invention further provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L wherein the capsule material comprises hydroxypropylmethylcellulose (HPMC) and titanium dioxide.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations used in the treatment of diseases, disorders or conditions of the nervous system, excluding pharmaceutical preparations for treating high blood pressure.
An improved inhalation device is provided for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device includes a staple assembly comprising a plunger and staple that are securely and robustly coupled to one another. Embodiments of the inhalation device have a cap that prevents or reduces the amount of dust and grime entering into the device. The cap is additionally configured to prevent or reduce inadvertent and unintentional operation of the device. The body portion and first casing portion of certain embodiments of the inhalation device are sealably coupled, restricting or reducing undesirable flow pathways that have an adverse effect on the operation of the device.
The present invention provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L. The invention further provides a capsule containing an inhalable powder composition wherein the composition comprises about 75% by weight or more levodopa, dipalmitoylphosphatidylcholine (DPPC) and a salt characterized by a working density of less than about 100 g/L wherein the capsule material comprises hydroxypropylmethylcellulose (HPMC) and titanium dioxide.
44 - Services médicaux, services vétérinaires, soins d'hygiène et de beauté; services d'agriculture, d'horticulture et de sylviculture.
Produits et services
Providing information and online information relating to diagnostic, prophylactic and therapeutic properties of pharmaceutical preparations for the prevention and treatment of diseases, disorders and conditions
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations; pharmaceutical and biological preparations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological disorders or conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical preparations; pharmaceutical and biological preparations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological disorders or conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological disorders or conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological disorders or conditions
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological disorders or conditions
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
(1) Pharmaceutical preparations for the treatment of function in neurological, neuromuscular, demyelinating, and neurodegenerative diseases and disorders, namely multiple sclerosis.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations, products and formulations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological or musculoskeletal diseases, disorders or conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations, products and formulations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological or musculoskeletal diseases, disorders or conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations, products and formulations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological or musculoskeletal diseases, disorders or conditions.
05 - Produits pharmaceutiques, vétérinaires et hygièniques
Produits et services
Pharmaceutical and biological preparations, products and formulations used in the treatment of spinal cord injuries, multiple sclerosis and other neurological or musculoskeletal diseases, disorders or conditions.
